Studies on the Pathogenesis of So-Called Banti's Disease Part Ⅲ. The Tissue Cultures of the Bone Marrow of the Rabbits with Experimental Splenomegaly

With bone marrow cultures of the rabbits given successive injections of methylcellulose, polyvinylalcohol and ovalbumin for a long period of time, the author studied the influences of such injections on the tissue growth and the cell migratory power; and obtained the following results. 1) The growth of the bone marrow tissue was clearly suppressed in all the groups tested. 2) The cell migratory power of bone marrow cells was also decreased rather appreciably in every group receiving the injections. From these results, it is concluded that the toxic factor created by injections acts not only as a causative factor for anemia and thrombocytopenia but it also acts on white cell series, thereby hindering the bone marsow tissue growth and diminishing the cell migratory power as well.