Histochemical studies on the cerebral cortex of epileptics. Part 1. On ketoenolic graules (low molecular DNA) in the cerebral cortex of epileptics

In epileptics the premotor area of the cerebral cortex was resected and the tissue was fixed, inbedded in paraffin and sectioned in 4 μ slices. The specimen was stained by HAMAZAKI KFJ-method and the ketoenolic granules (KEG) were investigated and its distribution was studied. 1. In idiopathic epileptics KEG increased. After the metrazol provocation it increased more intensively. 2. In symptomatic epileptics no increasing was found. 3. Generally in the nerve cells in premotor area in cerebral cortex KEG was found more in deeper layers than in superficial layers, especially most in the large pyramidal cells. As above mentioned it is confirmed histochemically that the nerve cells in the cerebral cortex of symptomatic epileptics were not so hypersensitive. On the contrary in idiopathic epileptics, which no organic changes were seen, they were hypersensitive.