Experimental Study on the Urinary 17-KS Excretion in Acute Pancreatitis

The author observed the quantities of urinary 17-KS excretion and the fluctuation of this substance up to the 20th day on the course of acute pancreatitis. This procedure was performed experimentally on the female rabbits. Also the influence of glucose and ascorbic acid on the response of the adrenal gland (17-KS excretion) to pancreatitis stress was observed, and the author has gained some results especially in regards to the signification of the fluctuation of this substance. The results obtained may be summarized as follows: 1) On the extra-serious cases, the urinary 17-KS excretion is shown extremely decreased on the 1st day, and the animals went to death on its continuously decreasing course. 2) On the serious cases the excretion decreases in the same manner on the 1st day, which is more remarkable in comparison with the degree of this decrease on control with simple laparotomy and peritonitis. After the 2nd day the excretion shows starting to increase, gradually returning to the preoperative level from the 10th to the 15th day. 3) On the mild cases the excretion curve is shown on the same way with the serious cases, but the decrease on the 1st day and the increase on or after the 2nd day are less on degree. 4) The count of eosinophiles decreases on the 1st day on the all cases. On the surviving cases it starts to increase on the second day, and on the 3rd day, is shown over the preoperative level. 5) At 12 hours after the onset of acute pancreatitis the adrenal glands were weighted over than control. 6) The urinary 17-KS excretion shows some decrease on starved animals. Starvaion or mal-nutrition can be understood as a factor of its decreasing on the 1st day of acute panereatitis. But the starvation cannot be contributed to explain the following increase. 7) The 17-KS excretion curves on serious acute pancreatitis with intravenous glucose administration are characterized by the increase starting on the 1st day. 8) Ascorbic acid pretreatment suppresses the decrease of the 17-KS excretion on the 1st day of the serious cases.