Studies on the Pathogenic Agent of Infectious Hepatitis in Okayama Prefecture II: Supplement to the Studies on the Skin Reaction by Isolated Virus

In the present part, together with the skin reaction which was reported in part, I, the author studied the clinical symptomes, liver function and pathological changes of liverpuncture materials to investigate the interrelation between the skin reaction and these clinical matters. The results were as follows: 1) The skin reaction showed a high positive rate when the hepatitisspecific blood picture, monocytosis, appearance of plasmocytes and relative lymphocytosis, appeared. Inthe prodromal stage, in which various indefinite symptomes developed, a high positive rate of skin reaction of 91 to 96% was obtained. This fact suggested that the skin reaction could be a help to the early and differential diagnosis of infectious hepatitis. 2) Even the cases, in which no noticeable disturbance of liver function was observed, showed a positive skin reaction. 3) In the relapse cases of chronic hepatitis, the skin reaction became severer in the active stage and weaker in the inactive stage, and the non-specific flush became bigger as the disease took a delayed chronic course.