Studies on the Kidney Function 2nd Chapter : The Kidney function at the time of Experimentally Liver-damaged

Sound rabbits and those subjected to a ligature of common bile duct were cut off either vagic or splanchinic nerve, or given either sulfric atropine, acetylcholine, hexamethonium bromide, or hydrochloric adrenalin, and the function of kidney in each case tested by clearance method, with the result as follows. 1. When sound rabbits are cut off vagic nerve or sulfuric atropine, urine volume increases, glomerular filtration rate decreases, effective renal plasma flow and effective renal blood flow increases, and filtration fraction decreases ; and reabsorpion rate decreases, and tubular excretory mass increases. Acetylcholine being given, the result will be contrary to the above. 2. When sound rabbits are cut off splanchinic nerve, urine volume increases remarkably, glomerular filtration rate decreases, effective renal plasma flow and effective renal blood flow increase remarkably, and filtration fraction decreases remarkably ; and reabsorption rate decrcases fairly and tubular excretory mass increases considerably. 3. When sound rabbits are given hexamethonium bromide, urine volume decreases, glomerular filtration rate decreases, effective renal plasma flow and effective renal blood flow increases. and filtration fraction decreases, reabsorption rate increses and tubular excretory mass decreases. 4. When sound rabbits are given sulfuric adrenalin at the proportion of 0.1 mg per kilogram of body weight, it is only filtration fraction that decreases, and the others increases to some respective extents. When given the same at the proportion of 0.5 mg., the result will be quite contrary. 5. When the rabbits subjectd to a ligature of common bile duct are cut off vagic nerve, urine volume decreases, glomerular filtration rate decreases, effective renal plasma flow and effective renal blood flow increase, and filtration fraction decreases; reabsorption rate and tubular excretory mass increase. When sulfuric atropine is given the result will be similar to the above, excepting only that reabsorption rate decreases. 6. When the rabbits subjected to a ligaure of common bile duct are given acetylcholine, the result will be quite the same as the case of sulfuric atropine, only with the exception that urine volume decreases. 7. When the rabbits subjected to a ligature of common bile duct are given hexamethonium bromide, every part of the function will decrease ; and when given hydrochloric adrenalin at the proportion of 0.5 mg. per kilogram of body weight, the result will be similar to the above, excepting that filtration fraction and reabsorption rate increase. 8. The total and direct bilirubin contained in serum in case of a ligature of common duct hardly undertakes any influence, even when vagic nerve is cut off or medicine is given. However, the bilirubin in urine increases when vagic nerve is cut off, and decrease when medicine is given. The ration of the bilirubin in urine in a minute and direct bilirubin in serum increases when vagic nerve is cut off, increases fairly when sulfuric atropine or acetylcholine is given, and decreases to a considerable degree when hexamethonium bromide or hydrochloric adrenalin is given.