The Value of Trental (or Tonophosphan) in Rickets. An Experimental Study.

Experiments were undertaken to determine the value of Trental, a sodium salt of dimethylamino-methylphenyl phosphoric acid, in rickets of young growing rabbits. The standard rickets-producing dietary was fed and, as a supplement, Trental was given subcutaneously. All the control animals which were fed the rickets-producing diet, without exception developed rickets. In the large series of animals received Trental developed rickets in somewhat slighter degree and showed a slightly better increase of both body weight and bone length than that of the control animals, although in the small series of the animals developed rickets to the same extent as the control animals.