Studies on the regulation of blood coagulation from the pharmacological point of view (Part III) On the influence of some parasympathetic poisons on the blood coagulation

Experimental results are as follows: 1. Pilocarpine, when injected intravenously, in from small to large doses in a rabbit (0.000-0.01), lengthens the coagulation time of blood having no direct action on the blood with added pilocarpine, increases fibrinogen and antithrombin, and decreases thrombin. Between both the curves of change in the amount of coagulative components, and the lengthening of coagulation time exists a well-defined parallelism. The action of pilocarpine, threfore, seems due to the change in quantity of coagulative components in the blood. Under the experimental results that the action of pilocarpine are hindered by the preliminary disposition of atropine, the explanation is suggested that pilocarpine retards the coagulation by stimulating the parasympathetic nerve. 2. By injecting acetylcholine in the dose 0.000-0.003g it decreases thrombin, and increases fibrinogen and antithrombin as pilocarpine does. 3. Experimenting on a rabbit, atropine given intravenously in small doses (0.0003-0.001g) quickens the coagulation time of the blood, and increrses thrombin slightly, in large doses (0.03-0.05g) retards the coagulation time and decreases thrombin. It does not have any influence upon fibrinogen and antithrombin, nor does the addition of various amounts of atropine to the blood-plasma upon the clotting time. In the case with atropine, it appears to act on the process of clotting by laming the parasymrathetic nerve, and in large doses by laming the sympathetic nerve simultaniously, with the function of many other organs. 4. In these experiments, making clear the influence of some parasympathetic poisons upon the blood coagulability and coagulative components, it is considered that the parasympathetic nerve regulates the blood coagulability in the body of animals.

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