An electroclinical study of localization-related epilepsies occurring before 6 months of age

To clarify the characteristics of localization-related epilepsies occurring before 6 monthes of age, I carried out an electroclinical study on 28 cases which had been followed up for more than one year after the onset. The subjects were divided into two groups : the controlled group (8 cases) and the refractory group (20 cases). The controlled group was defined as the subjects whose seizures were suppressed within one year after the onset and the other subjects were classified into the refractory group. The characteristies of the refractory group were as follows : Most cases had serious underlying pathologies. The seizure type of most cases was simple partial seizure or complex partial seizure or complex partial seizure without secondary generalization. The inter-ictal EEG showed focal abnormalities and severe dysrrythmia on the basic pattern associated with mulitifocal spikes in most cases. Some cases developed West syndrome after localization-related epilepsies, and generalized seizures or pseudoabsences appeared later in some other cases. In conclusion, a comprehensive assessment and an intensive follow-up of clinical and EEG manifestations are of great value for determining the prognosis localization-related epilepsies occurring in early infancy.

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