Regional cerebral blood flow in Parkinson's disease by (123)I-IMP SPECT

Regional cerebral blood flow (rCBF) was evaluated in 63 patients with Parkinson's disease (PD) by single-photon emission computed tomography (SPECT) using N-isopropyl-p-(123)I-iodoamphetamine ((123)I-IMP) as a tracer. Evaluation of the SPECT images was performed in accordance with the rCBF quantification method using a microsphere model. Patients in stage Ⅳ demonstrated significanlty lower rCBF than those in stage Ⅱ at the frontal, tempo-ral, parietal, occipital regions and in the thalamus and celebellum. Subjects with mental sumptoms demonstrated decreased rCBF in every region in the brain. The present study indicates that clinical exacerbation and manifestation of dementia and other psychiatric aymptoms in Parkinson's disease are associated with decreased blood flow in various brain regions.

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