Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

亜硝酸イオンによる正常およびアカタラセミアマウス赤血球のメトヘモグロビン生成に関する試験管内およびマウス投与実験

Ioku, Naoya
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Abstract
The formation of methemoglobin from hemoglobin by nitrite ion in the erythrocytes of normal and acatalasemic mice and that in the erythrocytes of both mice injected with nitrite ion were studied. The formation of methemoglobin from hemoglobin by nitrite ion in red cells with or without the addition of glucose in vitro was also studied. Methemoglobin concentration in red cells of acatalasemic mice after the addition of NaNO(2) was higher than that in red cells of normal mice. The addition of glucose inhibited the formation of methemoglobin from hemoglobin by nitrite ion. Methemoglobin concentration in the blood of mice injected with NaNO(2) (1550μg/g) was determined. The results indicated that methemoglobin concentration in the blood of acatalasemic mice is higher than that in the blood of normal mice. These results indicated that the formation of methemoglobin from hemoglobin by nitrite ion appears to be controlled by the activity of blood catalase.
Keywords
亜硝酸イオン
カタラーゼ
メトヘモグロビン
ISSN
0030-1558
NCID
AN00032489