岡山大学環境理工学部研究報告 ISSN 2187-6940
Published by Faculty of Environmental Science and Technology, Okayama University

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ポリ(乳酸-エチレングリコール)トリブロック共重合体の乳化特性

Matsumoto, Yasuo
Kitamura, Yoshiro
Yoshizawa, Hidekazu
Abstract
Homo-and copolymers of poly(lactic acid) have gathered much attention because of their biodegradability and biocompatibility. They have numerous applications in the biomedical field due to their potential. In their polymers, we are interested in poly(lactic acid)-poly(ethylene glycol) block polymers. The amphiphilic triblock copolymers, poly(DL-lactic acid)-poly(ethylene glycol)-poly(DL-lactic acid)(PLEL), have known to be surface-active ability. Therefore, we have studied emulsification properties with the polymers. PLEL were prepared by ring-opening copolymerization of DL-lactide and poly(ethylene glycol) catalyzed by stannous 2-ethylhexanoate. We prepared ethyl acetate-water-PLEL emulsion and applied this emulsion to biodegradable polymer scaffolds. PLA scaffolds were prepared by an emulsion freeze-drying method. These scaffolds were made by varying water weight fraction. Their surface pore size became larger with increasing water weight fraction.
Keywords
Poly(lactic acid)
Poly(ethylene glycol)
Biodegradable polymer
Tissue Engineering
Surfactant
ISSN
1341-9099
NCID
AN10529213