Acta Medica Okayama volume74 issue2
2020-04 発行

Conventional versus Rapid Glucocorticoid Tapering in Severe Systemic Lupus Erythematosus Patients: A Non-Blind, Randomized Controlled Trial

Abe, Yoshiyuki Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Fujibayashi, Kazutoshi Medical Technology Innovation Center, Juntendo University
Nishizaki, Yuji Medical Technology Innovation Center, Juntendo University
Yanagisawa, Naotake Medical Technology Innovation Center, Juntendo University
Nojiri, Shuko Medical Technology Innovation Center, Juntendo University
Kon, Takayuki Department of Internal Medicine and Rheumatology, Juntendo University Nerima Hospital
Tada, Kurisu Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Yamaji, Ken Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Tamura, Naoto Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Publication Date
2020-04
Abstract
Glucocorticoids (GCs) have long played a central role in the treatment of systemic lupus erythematosus (SLE), but these drugs have many adverse effects. We will determine whether rapid weekly GC tapering is non-inferior to conventional biweekly tapering in patients with severe SLE. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the relapse-free survival rate at 52 weeks. The main secondary outcome is the prevalence of the Lupus Low Disease Activity State at 52 weeks. The trial will determine the optimal method of tapering GCs in patients with severe SLE.
Document Type
Clinical Study Protocol
Keywords
systemic lupus erythematosus
relapse-free survival rate
glucocorticoid, tapering
Lupus Low Disease
Activity State
Link to PubMed
Thumnail 74_2_179.pdf 1.93 MB