Acta Medica Okayama volume74 issue2
2020-04 発行

The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma

Fukuhara, Ryuichiro Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Shinya, Takayoshi Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Fukuma, Shogo Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Ogawa, Nanako Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Masaoka, Yoshihisa Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Tanaka, Takehiro Department of Pathology, Okayama Diagnostic Imaging Center, Okayama university Hospital Kaken ID
Marunaka, Hidenori Department of Otolaryngology-Head & Neck Surgery, Okayama Diagnostic Imaging Center, Okayama university Hospital
Arioka, Tadashi Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Hiraki, Takao Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital Kaken ID researchmap
Kaji, Mitsumasa Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Kanazawa, Susumu Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital Kaken ID
Publication Date
2020-04
Abstract
The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly.
Document Type
Original Article
Keywords
18F-fluorodeoxyglucose positron emission tomography/computed tomography
extranodular spread
metastasis
oral squamous cell carcinoma
Link to PubMed
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