Acta Medica Okayama volume74 issue2
2020-04 発行

Effects of Switching from Treatment with Amlodipine and Atorvastatin Using Two Pills to an Equal Dose of Single-Pill Therapy in Japanese Outpatients

Kawada, Yasumasa Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
Kubo, Toru Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
Baba, Yuichi Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
Hirota, Takayoshi Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
Tanioka, Katsutoshi Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
Yamasaki, Naohito Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
Kitaoka, Hiroaki Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
Publication Date
2020-04
Abstract
This study examined whether switching from amlodipine and atorvastatin treatment using two pills to an equal dose of single-pill therapy is useful in Japanese outpatients. We retrospectively reviewed data obtained from 94 outpatients for whom treatment with two pills, namely amlodipine and atorvastatin, was switched to an equal dose of single-pill therapy in 11 hospitals. The criterion for enrollment in this study was that patients had switched their medication without changing other anti-hypertensive or anti-cholesterol drugs. Neither systolic nor diastolic blood pressure changed significantly after switching to an equal dose of single-pill therapy, whereas low-density lipoprotein (LDL) cholesterol levels significantly decreased after the medication was switched from 94±24 mg/dl to 89±17 mg/dl (p=0.015). A switch from medication with two separate pills of amlodipine and atorvastatin to an equal dose of single-pill therapy resulted in an overall decrease in LDL cholesterol. The results indicated that the switch to single-pill therapy might be a useful treatment.
Document Type
Original Article
Keywords
hypertension
dyslipidemia
single-pill therapy
Link to PubMed
Thumnail 74_2_103.pdf 2.23 MB