start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=2 article-no= start-page=75 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Potential for Radiation Dose Reduction in Temporal Bone CT Imaging Using Photon-Counting Detector CT en-subtitle= kn-subtitle= en-abstract= kn-abstract=Temporal bone computed tomography (CT) is frequently performed for pediatric patients with ear diseases. Advances in CT technology have improved diagnostic imaging quality, but reduction of radiation exposure remains a goal. We evaluated the potential for radiation dose reduction in temporal bone CT examinations using porcine ear ossicles and a photon-counting detector CT system. Three scans of the bilateral temporal bone were performed on each of three pig cadaver heads. In each of seven successive imaging sessions, the radiation dose was reduced by an additional one-seventh of the recommended dose (RD). Two board-certified radiologists independently scored the resulting images on a scale of 1 to 5 points, where 5 represented the image quality at the RD. Images scoring ≥4.5 points were considered acceptable. Noise was assessed in a 2-cm-diameter region near the ear ossicles, and standard deviation was measured for each of the seven decrements from the RD. As the radiation dose decreased, the noise progressively increased, and visual assessment scores progressively decreased. Acceptable image scores were obtained at six-sevenths (4.9), five-sevenths (4.8), four-sevenths (4.7), and three-sevenths (4.6) of the RD. Thus, acceptable porcine temporal bone CT images were obtained with a radiation dose reduction of approximately 50%. en-copyright= kn-copyright= en-aut-name=HigakiFumiyo en-aut-sei=Higaki en-aut-mei=Fumiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorimitsuYusuke en-aut-sei=Morimitsu en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HwangSung Il en-aut-sei=Hwang en-aut-mei=Sung Il kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KitayamaTakahiro en-aut-sei=Kitayama en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiYuka en-aut-sei=Takahashi en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AkagiNoriaki en-aut-sei=Akagi en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SugayaAkiko en-aut-sei=Sugaya en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiological Technology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Radiology, Seoul National University Bundang Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiological Technology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Hospital kn-affil= affil-num=10 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Radiology, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Radiology, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=computed tomography kn-keyword=computed tomography en-keyword=photon-counting detector computed tomography kn-keyword=photon-counting detector computed tomography en-keyword=ear ossicle kn-keyword=ear ossicle en-keyword=energy-integrating detector computed tomography kn-keyword=energy-integrating detector computed tomography END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=1 article-no= start-page=100 end-page=107 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Investigating the Effects of Reconstruction Conditions on Image Quality and Radiomic Analysis in Photon-counting Computed Tomography en-subtitle= kn-subtitle= en-abstract= kn-abstract=Introduction:Photon-counting computed tomography (CT) is equipped with an adaptive iterative reconstruction method called quantum iterative reconstruction (QIR), which allows the intensity to be changed during image reconstruction. It is known that the reconstruction conditions of CT images affect the analysis results when performing radiomic analysis. The aim of this study is to investigate the effect of QIR intensity on image quality and radiomic analysis of renal cell carcinoma (RCC).
Materials and Methods:The QIR intensities were selected as off, 2 and 4. The image quality evaluation items considered were task-based transfer function (TTF), noise power spectrum (NPS), and low-contrast object specific contrast-to-noise ratio (CNRLO). The influence on radiomic analysis was assessed using the discrimination accuracy of clear cell RCC.
Results:For image quality evaluation, TTF and NPS values were lower and CNRLO values were higher with increasing QIR intensity; for radiomic analysis, sensitivity, specificity, and accuracy were higher with increasing QIR intensity. Principal component analysis and receiver operating characteristics analysis also showed higher values with increasing QIR intensity.
Conclusion:It was confirmed that the intensity of the QIR intensity affects both the image quality and the radiomic analysis. en-copyright= kn-copyright= en-aut-name=OhataMiyu en-aut-sei=Ohata en-aut-mei=Miyu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiRyohei en-aut-sei=Fukui en-aut-mei=Ryohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MorimitsuYusuke en-aut-sei=Morimitsu en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KobayashiDaichi en-aut-sei=Kobayashi en-aut-mei=Daichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamauchiTakatsugu en-aut-sei=Yamauchi en-aut-mei=Takatsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AkagiNoriaki en-aut-sei=Akagi en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HondaMitsugi en-aut-sei=Honda en-aut-mei=Mitsugi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HayashiAiko en-aut-sei=Hayashi en-aut-mei=Aiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HasegawaKoshi en-aut-sei=Hasegawa en-aut-mei=Koshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KidaKatsuhiro en-aut-sei=Kida en-aut-mei=Katsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=GotoSachiko en-aut-sei=Goto en-aut-mei=Sachiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Division of Radiological Technology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Division of Radiological Technology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Division of Radiological Technology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Division of Radiological Technology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Division of Radiological Technology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Hiroshima University Hospital kn-affil= affil-num=9 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical, Okayama University kn-affil= en-keyword=Image quality kn-keyword=Image quality en-keyword=photon-counting computed tomography kn-keyword=photon-counting computed tomography en-keyword=quantum iterative reconstruction kn-keyword=quantum iterative reconstruction en-keyword=radiomics kn-keyword=radiomics en-keyword=renal cell carcinoma kn-keyword=renal cell carcinoma END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=1 article-no= start-page=21 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202502 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prediction of Prostate Cancer Grades Using Radiomic Features en-subtitle= kn-subtitle= en-abstract= kn-abstract=We developed a machine learning model for predicting prostate cancer (PCa) grades using radiomic features of magnetic resonance imaging. 112 patients diagnosed with PCa based on prostate biopsy between January 2014 and December 2021 were evaluated. Logistic regression was used to construct two prediction models, one using radiomic features and prostate-specific antigen (PSA) values (Radiomics model) and the other Prostate Imaging-Reporting and Data System (PI-RADS) scores and PSA values (PI-RADS model), to differentiate high-grade (Gleason score [GS] ≥ 8) from intermediate or low-grade (GS < 8) PCa. Five imaging features were selected for the Radiomics model using the Gini coefficient. Model performance was evaluated using AUC, sensitivity, and specificity. The models were compared by leave-one-out cross-validation with Ridge regularization. Furthermore, the Radiomics model was evaluated using the holdout method and represented by a nomogram. The AUC of the Radiomics and PI-RADS models differed significantly (0.799, 95% CI: 0.712-0.869; and 0.710, 95% CI: 0.617-0.792, respectively). Using holdout method, the Radiomics model yielded AUC of 0.778 (95% CI: 0.552-0.925), sensitivity of 0.769, and specificity of 0.778. It outperformed the PI-RADS model and could be useful in predicting PCa grades, potentially aiding in determining appropriate treatment approaches in PCa patients. en-copyright= kn-copyright= en-aut-name=YamamotoYasuhiro en-aut-sei=Yamamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HaraguchiTakafumi en-aut-sei=Haraguchi en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsudaKaori en-aut-sei=Matsuda en-aut-mei=Kaori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkazakiYoshio en-aut-sei=Okazaki en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KimotoShin en-aut-sei=Kimoto en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TanjiNozomu en-aut-sei=Tanji en-aut-mei=Nozomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsumotoAtsushi en-aut-sei=Matsumoto en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KobayashiYasuyuki en-aut-sei=Kobayashi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MimuraHidefumi en-aut-sei=Mimura en-aut-mei=Hidefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Radiology, Houshasen Daiichi Hospital kn-affil= affil-num=2 en-affil=Department of Advanced Biomedical Imaging and Informatics, St. Marianna University School of Medicine kn-affil= affil-num=3 en-affil=Department of Radiology, Houshasen Daiichi Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Houshasen Daiichi Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Houshasen Daiichi Hospital kn-affil= affil-num=6 en-affil=Department of Urology, Houshasen Daiichi Hospital kn-affil= affil-num=7 en-affil=Department of Urology, Houshasen Daiichi Hospital kn-affil= affil-num=8 en-affil=Department of Medical Information and Communication Technology Research, St. Marianna University School of Medicine kn-affil= affil-num=9 en-affil=Department of Radiology, St. Marianna University School of Medicine kn-affil= affil-num=10 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=prostate cancer kn-keyword=prostate cancer en-keyword=machine learning kn-keyword=machine learning en-keyword=prostate Imaging-Reporting and Data System kn-keyword=prostate Imaging-Reporting and Data System en-keyword=radiomics kn-keyword=radiomics en-keyword=Gleason score kn-keyword=Gleason score END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=3 article-no= start-page=548 end-page=556 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230407 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Outcomes of solitary postoperative recurrence of esophageal squamous cell carcinoma diagnosed with FDG-PET/CT and treated with definitive radiation therapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background Surgical resection of esophageal cancer is frequently performed to achieve a complete cure. However, the postoperative recurrence rate is 36.8–42.5%, leading to poor prognosis. Radiation therapy has been used to treat recurrences; solitary recurrence has been proposed as a prognostic factor for radiation therapy, though its significance is unclear. 18F-fluorodeoxyglucose positron emission tomography is a highly accurate diagnostic modality for esophageal cancer. This retrospective study aimed to analyze the outcomes of solitary postoperative recurrences of esophageal squamous cell carcinoma diagnosed with 18F-fluorodeoxyglucose positron emission tomography and treated with definitive radiation therapy.
Methods We examined 27 patients who underwent definitive radiation therapy for single or multiple postoperative recurrences of esophageal squamous cell carcinoma between May 2015 and April 2021. 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed within 3 months before the commencement of radiation therapy. Kaplan–Meier, univariate, and multivariate analyses were performed to examine the overall survival and identify potential prognostic factors.
Results The 1-, 2-, and 3-year overall survival rates were 85.2%, 62.6%, and 47.3%, respectively, and solitary recurrence was the only significant factor associated with overall survival (P = 0.003). The 1-, 2-, and 3-year overall survival rates in patients with solitary recurrence were 91.7%, 80.2%, and 80.2%, respectively, and in patients with multiple recurrences they were 80.0%, 50.3%, and 25.1%, respectively. Multivariate analysis also showed solitary recurrence as a significant factor for overall survival.
Conclusions When diagnosed with 18F-fluorodeoxyglucose positron emission tomography/computed tomography, solitary recurrence appears to have a more favorable prognosis than multiple recurrences. en-copyright= kn-copyright= en-aut-name=IharaHiroki en-aut-sei=Ihara en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshioKotaro en-aut-sei=Yoshio en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SugiyamaSoichi en-aut-sei=Sugiyama en-aut-mei=Soichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HashimotoMasashi en-aut-sei=Hashimoto en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MaedaNaoaki en-aut-sei=Maeda en-aut-mei=Naoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AkagiShinsuke en-aut-sei=Akagi en-aut-mei=Shinsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakaoSoshi en-aut-sei=Takao en-aut-mei=Soshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Proton Beam Therapy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Proton Beam Therapy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Radiation therapy kn-keyword=Radiation therapy en-keyword=Esophageal squamous cell carcinoma kn-keyword=Esophageal squamous cell carcinoma en-keyword=Recurrence kn-keyword=Recurrence en-keyword=18F-fluorodeoxyglucose positron emission tomography kn-keyword=18F-fluorodeoxyglucose positron emission tomography en-keyword=Survival kn-keyword=Survival END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=4 article-no= start-page=398 end-page=405 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231122 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Time course of complications after small renal mass biopsy: evaluation of initial follow-up images en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose To retrospectively assess the time course of complications after image-guided small renal mass biopsy using initial follow-up imaging.
Materials and methods A total of 190 masses (mean, 2.1 ± 0.70 cm; range, 0.6–3.8 cm) were assessed using initial computed tomography (43 non-enhanced and 141 enhanced) or magnetic resonance imaging (five non-enhanced and one enhanced) after biopsy. Initial follow-up imaging was classified into two groups (i.e., with or without hematoma) and various factors were compared.
Results The masses were histologically diagnosed in all patients except one. Post-procedural complications included 129 Grade I hematomas, 1 Grade I hemothorax, 9 Grade II hematomas, and 1 Grade IIIa pneumothorax. Residual 28 Grade I and 6 Grade II hematomas and 8 new complications (6 small hematomas, 1 pseudoaneurysm, and 1 arteriovenous fistula) were observed on the initial follow-up imaging obtained at a median of 21 days (3–90 days) after the biopsy. On the initial follow-up imaging, the groups with and without hematoma differed significantly in the following factors: age (P = 0.04), size (P = 0.02), guided images (P < 0.01), hematoma at the end of the procedure (P < 0.01), and days after biopsy (P < 0.01). Although three masses exhibited > 25% shrinkage, no significant change was observed in mass diameter on initial follow-up imaging (mean, 2.1 ± 0.71 cm; P = 0.90).
Conclusion Initial follow-up imaging after a biopsy revealed improvements in most of the complications, a few new complications, and an unchanged mass diameter. en-copyright= kn-copyright= en-aut-name=KajitaSoichiro en-aut-sei=Kajita en-aut-mei=Soichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TomitaKoji en-aut-sei=Tomita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UmakoshiNoriyuki en-aut-sei=Umakoshi en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawabataTakahiro en-aut-sei=Kawabata en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MunetomoKazuaki en-aut-sei=Munetomo en-aut-mei=Kazuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Biopsy kn-keyword=Biopsy en-keyword=Imaging kn-keyword=Imaging en-keyword=Complication kn-keyword=Complication en-keyword=Renal neoplasms kn-keyword=Renal neoplasms END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=3 article-no= start-page=319 end-page=325 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231014 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prospective evaluation of core number of biopsy for renal tumor: are multiple cores preferable? en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose This single-center, single-arm, prospective, open-label study was conducted to evaluate the optimal number of cores (single or multiple) in renal tumor biopsy.
Materials and methods Forty-four biopsies of 44 tumors (mean diameter, 2.7 ± 1.0 cm; range, 1.6–5.0 cm) were included. Biopsy was performed under ultrasound or computed tomography fluoroscopy guidance using an 18-gauge cutting needle and the co-axial method. Two or more specimens were obtained, which were divided into first and subsequent specimens. “First specimen” and “all specimens” were histologically evaluated (i.e., appropriateness of specimen, histological diagnosis, subtype, and Fuhrman grade of renal cell carcinoma [RCC]) blindly and independently by two board-certified pathologists.
Results Multiple specimens were successfully and safely obtained in all the biopsies. All tumors were histologically diagnosed; 40 malignancies included 39 RCCs and 1 solitary fibrous tumor, and 4 benign lesions included 2 angiomyolipomas, 1 oncocytoma, and 1 capillary hemangioma. In all RCCs, the subtype could be determined (32 clear cell RCCs, 4 chromophobe RCCs, and 3 papillary RCCs), and the Furman grade was determined in 38 RCCs. When only the first specimen was evaluated, 22.7% of the specimens were inappropriate for diagnosis, and 34 (77.3%) were histologically diagnosed. The diagnostic yield was significantly lower than that of all specimens (P = 0.0044). Univariate analysis revealed that smaller lesions were a significant predictor of diagnostic failure (P = 0.020).
Conclusion Biopsy with multiple cores significantly improved diagnostic yield. Thus, operators should obtain multiple cores during renal tumor biopsy. en-copyright= kn-copyright= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TojiTomohiro en-aut-sei=Toji en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakuraiJun en-aut-sei=Sakurai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TomitaKoji en-aut-sei=Tomita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=UmakoshiNoriyuki en-aut-sei=Umakoshi en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawabataTakahiro en-aut-sei=Kawabata en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MunetomoKazuaki en-aut-sei=Munetomo en-aut-mei=Kazuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Biopsy kn-keyword=Biopsy en-keyword=Kidney kn-keyword=Kidney en-keyword=Tumor kn-keyword=Tumor en-keyword=Computed tomography kn-keyword=Computed tomography en-keyword=Ultrasound kn-keyword=Ultrasound END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=2 article-no= start-page=135 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photon-Counting Detector CT: Potential for 75% Reduction in Contrast Medium Amount: A Phantom Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study aimed to evaluate the potential reduction in contrast medium utilization using photon-counting detector computed tomography (PCD-CT). One PCD-CT scan (CT1) and three conventional (non-PCD-CT) CT scans (CT2-CT4) were performed using a multi-energy CT phantom that contained eight rods with different iodine concentrations (0.2, 0.5, 1, 2, 5, 10, 15, and 20 mg/ml). The CT values of the seven groups (CT1 for 40, 50, 60, and 70 keV; and CT2-4) were measured. Noise and contrast-to-noise ratio (CNR) were assessed for the eight rods at various iodine concentrations. CT2 and CT1 (40 keV) respectively required 20 mg/ml and 5 mg/ml of iodine, indicating that a comparable contrast effect could be obtained with approximately one-fourth of the contrast medium amount. The standard deviation values increased at lower energy levels irrespective of the iodine concentration. The CNR exhibited a decreasing trend with lower iodine concentrations, while it remained relatively stable across all iodine levels (40-70 keV). This study demonstrated that virtual monochromatic 40 keV images offer a similar contrast effect with a reduced contrast medium amount when compared to conventional CT systems at 120 kV. en-copyright= kn-copyright= en-aut-name=HigakiFumiyo en-aut-sei=Higaki en-aut-mei=Fumiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorimitsuYusuke en-aut-sei=Morimitsu en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SaitoHayato en-aut-sei=Saito en-aut-mei=Hayato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakakiHaruhiko en-aut-sei=Takaki en-aut-mei=Haruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakagoshiAyako en-aut-sei=Nakagoshi en-aut-mei=Ayako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WadaMaki en-aut-sei=Wada en-aut-mei=Maki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AkagiNoriaki en-aut-sei=Akagi en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiological Technology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Radiological Technology, Okayama University Medical School kn-affil= affil-num=5 en-affil=Department of Radiological Technology, Okayama University Medical School kn-affil= affil-num=6 en-affil=Department of Radiological Technology, Okayama University Medical School kn-affil= affil-num=7 en-affil=Department of Radiological Technology, Okayama University Medical School kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Radiological Technology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Radiology, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Radiology, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=photon-counting detector CT kn-keyword=photon-counting detector CT en-keyword=energy integrating detector CT kn-keyword=energy integrating detector CT en-keyword=computed tomography kn-keyword=computed tomography en-keyword=contrast medium amount kn-keyword=contrast medium amount en-keyword=reduction kn-keyword=reduction END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=2 article-no= start-page=158 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230827 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of the ear ossicles with photon-counting detector CT en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recently, computed tomography with photon-counting detector (PCD-CT) has been developed to enable high-resolution imaging at a lower radiation dose. PCD-CT employs a photon-counting detector that can measure the number of incident X-ray photons and their energy. The newly released PCD-CT (NAEOTOM Alpha, Siemens Healthineers, Forchheim, Germany) has been in clinical use at our institution since December 2022. The PCD-CT offers several advantages over current state-of-the-art energy-integrating detector CT (EID-CT). The PCD-CT does not require septa to create a detector channel, while EID-CT does. Therefore, downsizing the anode to achieve higher resolution does not affect the dose efficiency of the PCD-CT. CT is an indispensable modality for evaluating ear ossicles. The ear ossicles and joints are clearly depicted by PCD-CT. In particular, the anterior and posterior legs of the stapes, which are sometimes unclear on conventional CT scans, can be clearly visualized. We present cases of congenital anomalies of the ossicular chain, ossicular chain dislocation, tympanosclerosis, and cholesteatoma in which PCD-CT was useful. This short article reports the usefulness of PCD-CT in the 3D visualization of the ear ossicles. en-copyright= kn-copyright= en-aut-name=TakahashiYuka en-aut-sei=Takahashi en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HigakiFumiyo en-aut-sei=Higaki en-aut-mei=Fumiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SugayaAkiko en-aut-sei=Sugaya en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AsanoYudai en-aut-sei=Asano en-aut-mei=Yudai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KojimaKatsuhide en-aut-sei=Kojima en-aut-mei=Katsuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MorimitsuYusuke en-aut-sei=Morimitsu en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AkagiNoriaki en-aut-sei=Akagi en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ItohToshihide en-aut-sei=Itoh en-aut-mei=Toshihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Otolaryngology‑Head and Neck Surgery, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiological Technology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiological Technology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of CT‑Research and Collaboration, Siemens Healthineers kn-affil= affil-num=9 en-affil=Department of Radiology, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Radiology, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=Photon-counting detector computed tomography kn-keyword=Photon-counting detector computed tomography en-keyword=Energy-integrating detectors kn-keyword=Energy-integrating detectors en-keyword=Ear ossicles kn-keyword=Ear ossicles en-keyword=High-resolution imaging kn-keyword=High-resolution imaging en-keyword=3D kn-keyword=3D END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=1 article-no= start-page=29 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Regression of Necrotic Lesions after Methotrexate Withdrawal in Patients with Methotrexate-Associated Lymphoproliferative Disorders: A Retrospective CT Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=This retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction between the baseline and initial follow-up CT scan was calculated. The association between necrosis within lesions and size changes was estimated via linear regression analyses using both crude and adjusted models. Necrosis was significantly more common in extranodal lesions (27 out of 30 lesions, 90%) than in nodal lesions (9 out of 59 lesions, 15%, p<0.001). In the crude model, the regression of necrotic lesions was 58.5% greater than that of non-necrotic lesions; the difference was statistically significant (p<0.001). Additionally, the longest diameter of necrotic lesions at the baseline CT scan was significantly greater than that of non-necrotic lesions (p<0.001). Based on the adjusted model, necrotic lesions showed 49.3% greater regression than non-necrotic lesions (p=0.017). Necrosis detected on a CT scan was found to be an independent predictor of regression after MTX withdrawal in patients with MTX-LPD. en-copyright= kn-copyright= en-aut-name=KitayamaTakahiro en-aut-sei=Kitayama en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaTakashi en-aut-sei=Tanaka en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KanieYuichiro en-aut-sei=Kanie en-aut-mei=Yuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MarukawaYohei en-aut-sei=Marukawa en-aut-mei=Yohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KojimaKatsuhide en-aut-sei=Kojima en-aut-mei=Katsuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakaoSoshi en-aut-sei=Takao en-aut-mei=Soshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama City Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama Saiseikai General Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=methotrexate kn-keyword=methotrexate en-keyword=lymphoproliferative disorder kn-keyword=lymphoproliferative disorder en-keyword=computed tomography kn-keyword=computed tomography en-keyword=necrosis kn-keyword=necrosis END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=6 article-no= start-page=665 end-page=669 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Omental Abscess after Laparoscopic Proximal Gastrectomy Successfully Treated with Percutaneous Drainage en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report the case details of a 65-year-old Japanese man with an omental abscess that was discovered 43 days after he underwent a laparoscopic proximal gastrectomy for gastric cancer. His chief complaint was mild abdominal pain that had persisted for several days. The abscess was diagnosed as a rare postoperative complication. We hesitated to perform a reoperation given the invasiveness of general anesthesia and surgery, plus the possibility of postoperative adhesions and because the patient’s general condition was stable and he had only mild abdominal pain. Percutaneous drainage using a 10.2-F catheter was performed with the patient under conscious sedation and computed tomography–fluoroscopy guidance, with no complications. After the procedure, the size of the abscess cavity was remarkably reduced, and 23 days later the catheter was withdrawn. en-copyright= kn-copyright= en-aut-name=SakuraiAtsunobu en-aut-sei=Sakurai en-aut-mei=Atsunobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TomitaKoji en-aut-sei=Tomita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KakiuchiYoshihiko en-aut-sei=Kakiuchi en-aut-mei=Yoshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KurodaShinji en-aut-sei=Kuroda en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=7 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=8 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=9 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=drainage kn-keyword=drainage en-keyword=omental abscess kn-keyword=omental abscess en-keyword=omental infarction kn-keyword=omental infarction en-keyword=proximal gastrectomy kn-keyword=proximal gastrectomy END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=6 article-no= start-page=647 end-page=650 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Case of Migration of a Hydrogel Spacer for Radiotherapy into the Pulmonary Artery en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 67-year-old man was referred to our hospital for the diagnosis and treatment of prostate cancer. Multidisciplinary discussion led to intensity-modulated radiotherapy preceded by hormone therapy. Before radiotherapy, a biodegradable hydrogel spacer (HS) was placed between the prostate and rectum to reduce radiation injury risk. Three weeks postplacement, pelvic magnetic resonance imaging revealed HS migration into the pelvic vein. Subsequent whole-body contrast-enhanced computed tomography (CECT) revealed HS migration into the pulmonary artery. The patient showed no symptoms or clinical signs. Radiotherapy was completed uneventfully. Complete absorption of the migrated HS was confirmed using CECT images 5 months postplacement. en-copyright= kn-copyright= en-aut-name=KojimaKatsuhide en-aut-sei=Kojima en-aut-mei=Katsuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiYuka en-aut-sei=Takahashi en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SugiyamaSoichi en-aut-sei=Sugiyama en-aut-mei=Soichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AsanoYudai en-aut-sei=Asano en-aut-mei=Yudai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkawaNanako en-aut-sei=Okawa en-aut-mei=Nanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MakimotoSatoko en-aut-sei=Makimoto en-aut-mei=Satoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HigakiFumiyo en-aut-sei=Higaki en-aut-mei=Fumiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Proton Beam Therapy, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=hydrogel spacer kn-keyword=hydrogel spacer en-keyword=prostate cancer kn-keyword=prostate cancer en-keyword=radiotherapy kn-keyword=radiotherapy en-keyword=pulmonary embolism kn-keyword=pulmonary embolism END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=11 article-no= start-page=1201 end-page=1209 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220621 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Percutaneous cryoablation for clinical T3a renal cell carcinoma (< 7 cm) with segmental vein involvement or perinephric fat invasion based on preoperative evaluation of high-resolution multidetector computed tomography scan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose　To retrospectively assess the feasibility, safety, renal function, technique efficacy rate, and survival of patients with clinical T3a renal cell carcinoma (RCC).
Materials and methods　Sixteen cryoablation sessions were performed in 14 patients (10 men; mean age, 69.8 ± 10.5 years; range, 49–90 years) with 14 clear cell T3a RCCs (mean, 3.3 ± 0.9 cm; range, 1.9–5.2 cm). One patient was on dialysis. Transcatheter arterial embolization was performed before cryoablation in 15 sessions. The primary endpoint was the technique efficacy rate. The secondary endpoints included feasibility, safety, renal function, and survival.
Results　Cryoablation was technically successful in all RCC cases. In two RCCs, cryoablation was performed twice because of local tumor progression. No major adverse events were observed. All patients were alive without metastases, with a median follow-up of 45 months (6−93 months). Complete response was achieved by cryoablation in 11 RCCs (78.6%). The primary and secondary technique efficacy rates were 77.1% and 84.4% at 1 year, 57.9% and 73.9% at 3 years, and 57.9% and 73.9% at 5 years, respectively. One patient underwent dialysis given a total contralateral nephrectomy due to another RCC 1 month after initial cryoablation and a total ipsilateral nephrectomy 46 months after initial cryoablation due to local progression. Except for two dialysis patients, of the 12 patients with a median follow-up of 41 months (6–93 months), none were on dialysis.
Conclusion　Cryoablation was safe and effective in T3a RCC, which mainly involved the renal venous branches and may represent an alternative treatment for inoperable patients. en-copyright= kn-copyright= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkawaNanako en-aut-sei=Okawa en-aut-mei=Nanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TomitaKoji en-aut-sei=Tomita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UmakoshiNoriyuki en-aut-sei=Umakoshi en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MunetomoKazuaki en-aut-sei=Munetomo en-aut-mei=Kazuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Radiology, Dentistry and Pharmaceutical Science, Okayama University Graduate School of Medicine kn-affil= affil-num=2 en-affil=Department of Radiology, Dentistry and Pharmaceutical Science, Okayama University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Radiology, Dentistry and Pharmaceutical Science, Okayama University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Radiology, Dentistry and Pharmaceutical Science, Okayama University Graduate School of Medicine kn-affil= affil-num=5 en-affil=Department of Radiology, Dentistry and Pharmaceutical Science, Okayama University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of Radiology, Dentistry and Pharmaceutical Science, Okayama University Graduate School of Medicine kn-affil= affil-num=7 en-affil=Department of Radiology, Dentistry and Pharmaceutical Science, Okayama University Graduate School of Medicine kn-affil= affil-num=8 en-affil=Division of Medical Informatics, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Urology, Dentistry and Pharmaceutical Science, Okayama University Graduate School of Medicine kn-affil= affil-num=10 en-affil=Department of Radiology, Dentistry and Pharmaceutical Science, Okayama University Graduate School of Medicine kn-affil= en-keyword=Kidney neoplasms kn-keyword=Kidney neoplasms en-keyword=Cryosurgery kn-keyword=Cryosurgery en-keyword=Image-guided kn-keyword=Image-guided END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=10 article-no= start-page=1035 end-page=1045 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220913 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evidence on percutaneous radiofrequency and microwave ablation for liver metastases over the last decade en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose　This review aimed to summarize the treatment outcomes of percutaneous radiofrequency ablation (RFA) and microwave ablation (MWA) for metastatic liver tumors based on the findings of published studies over the last decade.
Materials and methods　Literature describing the survival outcomes of ablation therapy for liver metastases was explored using the PubMed database on April 26, 2022, and articles published in 2012 or later were selected. The included studies met the following criteria: (i) English literature, (ii) original clinical studies, and (iii) literature describing overall survival (OS) of thermal ablation for metastatic liver tumors. All case reports and cohort studies with fewer than 20 patients and those that evaluated ablation for palliative purposes were excluded.
Results　RFA was the most commonly used method for ablation, while MWA was used in several recent studies. RFA and MWA for liver metastases from various primary tumors have been reported; however, majority of the studies focused on colorectal cancer. The local control rate by RFA and MWA varied widely among the studies, ranging approximately 50–90%. Five-year survival rates of 20–60% have been reported following ablation for colorectal liver metastases by a number of studies, and several reports of 10-year survival rates were also noted.
Conclusion　Comparative studies of local therapies for colorectal liver metastases demonstrated that RFA provides comparable survival outcomes to surgical metastasectomy and stereotactic body radiation therapy. en-copyright= kn-copyright= en-aut-name=TomitaKoji en-aut-sei=Tomita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UmakoshiNoriyuki en-aut-sei=Umakoshi en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawabataTakahiro en-aut-sei=Kawabata en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MunetomoKazuaki en-aut-sei=Munetomo en-aut-mei=Kazuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NagataShoma en-aut-sei=Nagata en-aut-mei=Shoma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Ablation kn-keyword=Ablation en-keyword=Liver kn-keyword=Liver en-keyword=Metastasis kn-keyword=Metastasis END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=10 article-no= start-page=1024 end-page=1034 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Up-to-date evidence on image-guided thermal ablation for metastatic lung tumors: a review en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of this review was to summarize the latest evidence on image-guided thermal ablation therapies for lung metastases. PubMed was used to search for relevant articles that reported the oncological outcomes of thermal ablation for metastatic lung tumors, and those published in 2010 or later were selected for review. Ablative therapies were applied for lung metastases from various types of primary tumors, but most commonly colorectal ones. Radiofrequency ablation (RFA) was the most evaluated technique, followed by microwave ablation (MWA). The local control rates of ablative therapies were generally favorable, approximately 80–90% in many studies. Representative studies demonstrated promising overall survival rates of approximately 50% or higher 5 years after ablation for lung metastases from colorectal cancer or mixed types of primary tumors. Nevertheless, the survival outcomes varied depending on the type of primary tumor and background factors of patients such as other metastases and comorbidities. Several studies had aimed to compare the outcomes of various ablative therapies such as RFA, MWA, and cryoablation; however, conclusive data are not yet available to determine the most appropriate ablation modality for lung metastases. Further data accumulation is needed, especially for long-term outcomes and comparisons with other therapies. en-copyright= kn-copyright= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TomitaKoji en-aut-sei=Tomita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UmakoshiNoriyuki en-aut-sei=Umakoshi en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawabataTakahiro en-aut-sei=Kawabata en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MunetomoKazuaki en-aut-sei=Munetomo en-aut-mei=Kazuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NagataShoma en-aut-sei=Nagata en-aut-mei=Shoma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Ablation kn-keyword=Ablation en-keyword=Lung kn-keyword=Lung en-keyword=Pulmonary kn-keyword=Pulmonary en-keyword=Metastasis kn-keyword=Metastasis END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=14 article-no= start-page=3665 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230718 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Image-Guided Ablation Therapies for Extrahepatic Metastases from Hepatocellular Carcinoma: A Review en-subtitle= kn-subtitle= en-abstract= kn-abstract=Simple Summary Although systemic therapies are a common treatment for patients with extrahepatic metastases from hepatocellular carcinoma (HCC), local ablative therapies, such as radiofrequency ablation, microwave ablation, and cryoablation, can be used in select patients who have metastases to the lung, bone, and other sites with curative or palliative intent. This review summarizes the currently available evidence on image-guided thermal ablation therapies for extrahepatic metastases from HCC. The most common sites of extrahepatic metastases from hepatocellular carcinoma (HCC) are the lungs, intra-abdominal lymph nodes, bones, and adrenal glands, in that order. Although systemic therapies are a common treatment for patients with extrahepatic metastases, local ablative therapies for the extrahepatic metastatic lesions can be performed in selected patients. In this article, the literature on image-guided thermal ablation for metastasis to each organ was reviewed to summarize the current evidence. Radiofrequency ablation was the most commonly evaluated technique, and microwave ablation, cryoablation, and percutaneous ethanol injection were also utilized. The local control rate of thermal ablation therapy was relatively favorable, at approximately 70-90% in various organs. The survival outcomes varied among the studies, and several studies reported that the absence of viable intrahepatic lesions was associated with improved survival rates. Since only retrospective data from relatively small studies has been available thus far, more robust studies with prospective designs and larger cohorts are desired to prove the usefulness of thermal ablation for extrahepatic metastases from HCC. en-copyright= kn-copyright= en-aut-name=UmakoshiNoriyuki en-aut-sei=Umakoshi en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TomitaKoji en-aut-sei=Tomita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawabataTakahiro en-aut-sei=Kawabata en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiological Technology, Okayama University Graduate School of Health Science kn-affil= affil-num=7 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=hepatocellular carcinoma kn-keyword=hepatocellular carcinoma en-keyword=extrahepatic metastases kn-keyword=extrahepatic metastases en-keyword=ablation therapy kn-keyword=ablation therapy en-keyword=radiofrequency ablation kn-keyword=radiofrequency ablation en-keyword=microwave ablation kn-keyword=microwave ablation en-keyword=cryoablation kn-keyword=cryoablation en-keyword=percutaneous ethanol injection kn-keyword=percutaneous ethanol injection END start-ver=1.4 cd-journal=joma no-vol=134 cd-vols= no-issue=3 article-no= start-page=145 end-page=151 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20221201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Non-vascular interventional radiology for lung cancer kn-title=肺癌に対する非血管系IVR en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name=平木隆夫 kn-aut-sei=平木 kn-aut-mei=隆夫 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学学術研究院医歯薬学域　放射線医学 en-keyword=肺癌（lung cancer） kn-keyword=肺癌（lung cancer） en-keyword=インターベンショナルラジオロジー（interventional radiology） kn-keyword=インターベンショナルラジオロジー（interventional radiology） en-keyword=非血管系（non-vascular） kn-keyword=非血管系（non-vascular） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Renal cryoablation combined with prior transcatheter arterial embolization in non-dialysis patients with stage 4 or 5 chronic kidney disease: a retrospective study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose　To retrospectively evaluate cryoablation combined with prior transcatheter arterial embolization (TAE) for renal cell carcinoma (RCC) in non-dialysis patients with stage 4 or 5 chronic kidney disease (CKD).
Materials and methods　Patients with stage 4 or 5 CKD undergoing TAE and cryoablation for RCC between May 2012 and October 2021 were included. TAE was selectively performed using iodized oil with absolute ethanol or gelatin sponge 1–14 days before cryoablation. Local efficacy, safety, and changes in renal function were evaluated.
Results　Nine patients (seven men and two women; median age, 64 years; range 52–88 years) with nine RCCs (mean diameter, 3.0 ± 1.0 cm; range 1.7–4.7 cm) were included. The mean pre-treatment estimated glomerular filtration rate (eGFR) was 24.2 ± 5.6 ml/min/1.73 m2 (range 10.4–29.2 ml/min/1.73 m2). The mean amount of contrast medium used in TAE was 58 ± 29 ml (range 40–128 ml). Except in one patient (grade 3 pyelonephritis), no grade ≥ 3 complications occurred. During the follow-up period (median, 18 months; range 7–54 months), no local tumor progression occurred. In two patients with pre-treatment eGFR of < 20 ml/min/1.73 m2, hemodialysis was initiated at 3 and 19 months after cryoablation. At their last follow-up, the remaining seven patients showed a decrease of 6.2 ± 5.3 ml/min/1.73 m2 (range 0.7–17.2 ml/min/1.73 m2) in their eGFR.
Conclusion　Cryoablation combined with TAE for RCC in non-dialysis patients with stage 4 or 5 CKD was effective and safe, with an acceptable impact on renal function. en-copyright= kn-copyright= en-aut-name=UmakoshiNoriyuki en-aut-sei=Umakoshi en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TomitaKoji en-aut-sei=Tomita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KawabataTakahiro en-aut-sei=Kawabata en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MunetomoKazuaki en-aut-sei=Munetomo en-aut-mei=Kazuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NagataShoma en-aut-sei=Nagata en-aut-mei=Shoma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Deptartment of Radiological Technology, Okayama University Graduate School of Health Science kn-affil= affil-num=3 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Division of Medical Informatics, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Urology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Renal cryoablation kn-keyword=Renal cryoablation en-keyword=Transcatheter arterial embolization kn-keyword=Transcatheter arterial embolization en-keyword=Chronic kidney disease kn-keyword=Chronic kidney disease END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=1 article-no= start-page=81 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202302 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Navicular Bone Fracture after Radiofrequency Ablation in a Patient with Osteoid Osteoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Osteoid osteoma (OO) is a benign bone tumor that presents with nocturnal pain. Computed tomography (CT)- guided radiofrequency ablation (RFA) has been widely performed for OO, and major adverse events post-RFA are rare. We report a case of OO in the left navicular bone of a 15-year-old male. He underwent RFA for OO, and the pain improved temporarily. At the 1-month follow-up, the patient complained of left foot pain, and a CT examination revealed a fracture of the ablated navicular bone. Fractures are rare but must be taken into account after bone RFA. en-copyright= kn-copyright= en-aut-name=TomitaKoji en-aut-sei=Tomita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakataEiji en-aut-sei=Nakata en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Orthopaedic Surgery, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=osteoid osteoma kn-keyword=osteoid osteoma en-keyword=radiofrequency ablation kn-keyword=radiofrequency ablation en-keyword=navicular bone kn-keyword=navicular bone en-keyword=fracture kn-keyword=fracture END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220705 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tumor size before image-guided brachytherapy is an important factor of local control after radiotherapy for cervical squamous cell carcinoma: analysis in cases using central shielding en-subtitle= kn-subtitle= en-abstract= kn-abstract=We analyzed the local control (LC) of cervical squamous cell carcinoma treated by computed tomography (CT)-based image-guided brachytherapy (IGBT) using central shielding (CS). We also examined the value of tumor diameter before brachytherapy (BT) as a factor of LC. In total, 97 patients were analyzed between April 2016 and March 2020. Whole-pelvic (WP) radiotherapy (RT) with CS was performed, and the total pelvic sidewall dose was 50 or 50.4 Gy; IGBT was delivered in 3-4 fractions. The total dose was calculated as the biologically equivalent dose in 2 Gy fractions, and distribution was modified manually by graphical optimization. The median follow-up period was 31.8 months (6.3-63.2 months). The 1- and 2-year LC rates were 89% and 87%, respectively. The hazard ratio was 10.11 (95% confidence interval: 1.48-68.99) for local recurrence in those with a horizontal tumor diameter >= 4 cm compared to those with < 4 cm before BT. In CT-based IGBT for squamous cell carcinoma, favorable LC can be obtained in patients with a tumor diameter < 4 cm before BT. However, if the tumor diameter is >= 4 cm, different treatment strategies such as employing interstitial-BT for dose escalation may be necessary. en-copyright= kn-copyright= en-aut-name=YoshioKotaro en-aut-sei=Yoshio en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IharaHiroki en-aut-sei=Ihara en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkamotoKazuhiro en-aut-sei=Okamoto en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuzukiEtsuji en-aut-sei=Suzuki en-aut-mei=Etsuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OgataTakeshi en-aut-sei=Ogata en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SugiyamaSoichi en-aut-sei=Sugiyama en-aut-mei=Soichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakamuraKeiichiro en-aut-sei=Nakamura en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NagaoShoji en-aut-sei=Nagao en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MasuyamaHisashi en-aut-sei=Masuyama en-aut-mei=Hisashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Proton Beam Therapy, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Obstetrics and Gynecology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Radiology, Tsuyama Central Hospital kn-affil= affil-num=6 en-affil=Department of Proton Beam Therapy, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Obstetrics and Gynecology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Obstetrics and Gynecology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Obstetrics and Gynecology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=cervical cancer kn-keyword=cervical cancer en-keyword=tumor size kn-keyword=tumor size en-keyword=squamous cell carcinoma kn-keyword=squamous cell carcinoma en-keyword=image-guided brachytherapy (IGBT) kn-keyword=image-guided brachytherapy (IGBT) en-keyword=central shielding (CS) kn-keyword=central shielding (CS) END start-ver=1.4 cd-journal=joma no-vol=2022 cd-vols= no-issue= article-no= start-page=9988216 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220407 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Two Cases of Duodenal Ulcers That Developed after Transcatheter Procedures for Unruptured Visceral Artery Aneurysms en-subtitle= kn-subtitle= en-abstract= kn-abstract=Herein, we report two cases of duodenal ulcers that developed after transcatheter procedures for the treatment of unruptured artery aneurysms. Both patients recovered after the administration of nothing by mouth, intravenous fluids, and proton-pump inhibitors. Notably, the duodenal ulcer was unchanged in one patient six days after endovascular treatment and improved in the other patient 13 days after angiography. These cases suggest that conservative treatment is acceptable in patients with duodenal ischemia that develops as an adverse effect of endovascular procedures. The usefulness of esophagogastroduodenoscopy in such patients has also been highlighted. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawaiYusuke en-aut-sei=Kawai en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology, Mitoyo General Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Practical Gastrointestinal Endoscopy, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=4 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=MRI multiparametric scoring system for pial blood supply of intracranial meningiomas en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Meningiomas are occasionally fed by pial blood supply (PBS). It is postulated that peritumoral flow void (PTFV), peritumoral brain edema (PTBE), and absence of an arachnoid plane (AP) are useful parameters for evaluating PBS. Purpose: To determine whether conventional magnetic resonance imaging (MRI) using a multiparametric scoring system (MSS) is a useful way to predict PBS. Material and Methods: Forty-six patients were included and divided: PBS and non-PBS groups. Differences between the groups in six parameters of MR imaging were analyzed: tumor size, tumor location, PTBE grade, AP grade, PTFV, and MIB1 labeling index (MIB1-LI) grade. Cutoff values were determined using receiver operating characteristic (ROC) curve analysis for the differentiation of both groups based on statistically significant parameters. All cases were scored as 1 (PBS) or 0 (non-PBS) for each parameter according to set thresholds. Individual scores were totaled for each case, yielding a combined score for each case to obtain a cutoff value using ROC curve analysis for the MSS. Results: Peritumoral brain edema grade, AP grade, PTFV, and MIB-LI grade were statistically associated with PBS. Receiver operating characteristic curve analyses showed that PTBE grade 3 or 4, AP grade 3 or 4, and PTFV positivity had the highest accuracy of 69%, 64%, and 68%, respectively. Regarding the MSS, a cutoff value of 2 had the highest accuracy of 71%; PBS diagnosis was indicated by at least two of the three parameters, namely, PTBE grade, AP grade, and PTFV. Conclusion: The MSS is a useful way to predict PBS in intracranial meningiomas on MRI. en-copyright= kn-copyright= en-aut-name=HigakiFumiyo en-aut-sei=Higaki en-aut-mei=Fumiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=InoueSatoshi en-aut-sei=Inoue en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OdaWakako en-aut-sei=Oda en-aut-mei=Wakako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsusueEiji en-aut-sei=Matsusue en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurosurgery, Okayama City Hospital kn-affil= affil-num=3 en-affil=Department of Pathology, Okayama City Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Tottori Prefectural Central Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=pial blood supply kn-keyword=pial blood supply en-keyword=peritumoral brain edema kn-keyword=peritumoral brain edema en-keyword=arachnoid plane kn-keyword=arachnoid plane en-keyword=peritumoral flow void kn-keyword=peritumoral flow void en-keyword=magnetic resonance imaging kn-keyword=magnetic resonance imaging END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue=1 article-no= start-page=4 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210128 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Bone microarchitectural analysis using ultra-high-resolution CT in tiger vertebra and human tibia en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background To reveal trends in bone microarchitectural parameters with increasing spatial resolution on ultra-high-resolution computed tomography (UHRCT) in vivo and to compare its performance with that of conventional-resolution CT (CRCT) and micro-CT ex vivo. Methods We retrospectively assessed 5 tiger vertebrae ex vivo and 16 human tibiae in vivo. Seven-pattern and four-pattern resolution imaging were performed on tiger vertebra using CRCT, UHRCT, and micro-CT, and on human tibiae using UHRCT. We measured six microarchitectural parameters: volumetric bone mineral density (vBMD), trabecular bone volume fraction (bone volume/total volume, BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), and connectivity density (ConnD). Comparisons between different imaging resolutions were performed using Tukey or Dunnett T3 test. Results The vBMD, BV/TV, Tb.N, and ConnD parameters showed an increasing trend, while Tb.Sp showed a decreasing trend both ex vivo and in vivo. Ex vivo, UHRCT at the two highest resolutions (1024- and 2048-matrix imaging with 0.25-mm slice thickness) and CRCT showed significant differences (p <= 0.047) in vBMD (51.4 mg/cm(3) and 63.5 mg/cm(3)versus 20.8 mg/cm(3)), BV/TV (26.5% and 29.5% versus 13.8 %), Tb.N (1.3 l/mm and 1.48 l/mm versus 0.47 l/mm), and ConnD (0.52 l/mm(3) and 0.74 l/mm(3)versus 0.02 l/mm(3), respectively). In vivo, the 512- and 1024-matrix imaging with 0.25-mm slice thickness showed significant differences in Tb.N (0.38 l/mm versus 0.67 l/mm, respectively) and ConnD (0.06 l/mm(3)versus 0.22 l/mm(3), respectively). Conclusions We observed characteristic trends in microarchitectural parameters and demonstrated the potential utility of applying UHRCT for microarchitectural analysis. en-copyright= kn-copyright= en-aut-name=InaiRyota en-aut-sei=Inai en-aut-mei=Ryota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakaharaRyuichi en-aut-sei=Nakahara en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MorimitsuYusuke en-aut-sei=Morimitsu en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AkagiNoriaki en-aut-sei=Akagi en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MarukawaYouhei en-aut-sei=Marukawa en-aut-mei=Youhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsushitaToshi en-aut-sei=Matsushita en-aut-mei=Toshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanakaTakashi en-aut-sei=Tanaka en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TadaAkihiro en-aut-sei=Tada en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NasuYoshihisa en-aut-sei=Nasu en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=2 en-affil=Intelligent Orthopaedic System Development, Okayama University Medical School kn-affil= affil-num=3 en-affil=Devision of Radiology, Medical Support Department, Okayama University Hospital kn-affil= affil-num=4 en-affil=Devision of Radiology, Medical Support Department, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=6 en-affil=Devision of Radiology, Medical Support Department, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=9 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=10 en-affil=Medical materials for musculoskeletal reconstruction, Okayama University Medical School kn-affil= affil-num=11 en-affil=Orthopaedic Surgery, Okayama University Medical School kn-affil= affil-num=12 en-affil=Orthopaedic Surgery, Okayama University Medical School kn-affil= affil-num=13 en-affil=Department of Radiology, Okayama University Medical School kn-affil= en-keyword=Osteoporosis kn-keyword=Osteoporosis en-keyword=Bone density kn-keyword=Bone density en-keyword=Tomography (x-ray computed) kn-keyword=Tomography (x-ray computed) en-keyword=X-ray microtomography kn-keyword=X-ray microtomography END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=1 article-no= start-page=11882 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=We intended to investigate whether muscle and adipose masses were associated with prognosis among patients with stage III non-small-cell lung cancer (NSCLC) who were undergoing chemoradiotherapy (CCRT). We retrospectively explored data of patients with stage III NSCLC who underwent definitive CCRT (>= 60 Gy) between January 2004 and March 2018 at our hospital. We examined the relationship of overall survival (OS) with body mass index (BMI), skeletal muscle index (SMI), psoas muscle index (PMI), visceral adipose tissue index (VAI), subcutaneous adipose tissue index (SAI), and visceral-to-subcutaneous adipose tissue area ratio (VSR) using log-rank tests for the univariate analysis and Cox proportional hazard models for the multivariate analysis. Overall, 16, 32, and 12 patients had stage IIIA, IIIB, and IIIC NSCLC, respectively. The total radiotherapy dose ranged from 60 Gy/30 fractions to 66 Gy/33 fractions. In the univariate analysis, the performance status (PS), BMI, and SMI were associated with OS, whereas the PMI, VAI, SAI, and VSR were not. In the multivariate analysis, the PS and SMI were associated with OS. The hazard ratios and 95% confidence intervals were 2.91 and 1.28-6.64 for PS, and 2.36 and 1.15-4.85 for SMI, respectively. The 1, 3, and 5-year OS rates were 92.1%, 59.6%, and 51.0% in patients with high SMI, and 63.6%, 53.8%, and 17.9% in patients with low SMI, respectively. The SMI correlated with prognosis in our study population, whereas adipose mass did not. Therefore, sarcopenia should be considered while predicting the OS in such patients. en-copyright= kn-copyright= en-aut-name=KatsuiKuniaki en-aut-sei=Katsui en-aut-mei=Kuniaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OgataTakeshi en-aut-sei=Ogata en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SugiyamaSoichi en-aut-sei=Sugiyama en-aut-mei=Soichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshioKotaro en-aut-sei=Yoshio en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Proton Beam Therapy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Radiology, Iwakuni Clinical Center kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=619 end-page=632 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=2021323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Imaging evaluation of hereditary renal tumors: a pictorial review en-subtitle= kn-subtitle= en-abstract= kn-abstract= More than 10 hereditary renal tumor syndromes (HRTSs) and related germline mutations have been reported with HRTS-associated renal and extrarenal manifestations with benign and malignant tumors. Radiologists play an important role in detecting solitary or multiple renal masses with or without extrarenal findings on imaging and may raise the possibility of an inherited predisposition to renal cell carcinoma, providing direction for further screening, intervention and surveillance of the patients and their close family members before the development of potentially lethal renal and extrarenal tumors. Renal cell carcinomas (RCCs) associated with von Hippel–Lindau disease are typically slow growing while RCCs associated with HRTSs, such as hereditary leiomyomatosis and renal cell carcinoma syndrome, are highly aggressive. Therefore, radiologists need to be familiar with clinical and imaging findings of renal and extrarenal manifestations of HRTSs. This article reviews clinical and imaging findings for the evaluation of patients with well-established HRTSs from a radiologist’s perspective to facilitate the clinical decision-making process for patient management. en-copyright= kn-copyright= en-aut-name=TanakaTakashi en-aut-sei=Tanaka en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawashimaAkira en-aut-sei=Kawashima en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MarukawaYohei en-aut-sei=Marukawa en-aut-mei=Yohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitayamaTakahiro en-aut-sei=Kitayama en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MasaokaYoshihisa en-aut-sei=Masaoka en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KojimaKatsuhide en-aut-sei=Kojima en-aut-mei=Katsuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Mayo Clinic kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Radiology, Okayama University Hospital kn-affil= en-keyword=Hereditary renal tumor syndrome kn-keyword=Hereditary renal tumor syndrome en-keyword=Von Hippel–Lindau disease kn-keyword=Von Hippel–Lindau disease en-keyword=Birt–Hogg–Dubé syndrome kn-keyword=Birt–Hogg–Dubé syndrome en-keyword=Tuberous sclerosis complex kn-keyword=Tuberous sclerosis complex en-keyword=Hereditary leiomyomatosis and renal cell carcinoma syndrome kn-keyword=Hereditary leiomyomatosis and renal cell carcinoma syndrome END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=39 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210223 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Lung stereotactic body radiation therapy for elderly patients aged >= 80 years with pathologically proven early-stage non-small cell lung cancer: a retrospective cohort study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background
Stereotactic body radiation therapy (SBRT) is an established therapy for medically inoperable early-stage non-small cell lung cancer (NSCLC). Many elderly patients are medically inoperable owing to comorbidities. Therefore, SBRT may be a useful therapy for elderly patients. However, the application of SBRT for patients aged ≥ 80 years has not been completely elucidated. Therefore, this study aimed to assess the clinical utility of SBRT for elderly patients aged ≥ 80 years with pathologically proven early-stage NSCLC.
Methods
We retrospectively evaluated the data of patients aged ≥ 80 years with pathologically proven primary NSCLC who underwent SBRT at our institution between January 2009 and March 2020. Treatment outcomes and toxicities were analyzed. We used the Kaplan–Meier method to estimate survival curves and the log-rank test to compare the survival curves. We performed univariate and multivariate Cox regression analyses. p-values < 0.05 were regarded significant.
Results
Sixty-four patients (65 lesions) were included, and the median follow-up period was 38.7 (range 3.5–95.7) months. The median age was 82.9 (range 80.0–94.8) years. Sixteen patients were medically operable, and 48 patients were medically inoperable. The prescribed dose of SBRT was either 48 Gy in four fractions or 60 Gy in 10 fractions. The median survival time was 60.0 months (95% confidence interval, 43.5–71.1). The 1-, 3-, and 5-year local control, cancer-specific survival, progression-free survival, and overall survival rates were 98.4%, 98.4%, 81.0%, and 88.9%; 90.1%, 93.7%, 58.9%, and 68.3%; and 87.4%, 83.5%, 38.2%, and 47.5%, respectively. Multivariate analysis revealed that inoperability and solid nodules were the predictors of poor overall survival after SBRT in elderly patients. Two patients (3.1%) had grade 3 radiation pneumonitis, and one patient (1.6%) had grade 5 radiation pneumonitis.
Conclusions
SBRT was feasible in patients aged ≥ 80 years with NSCLC. It achieved good local control with minimal toxicity. SBRT may be beneficial in elderly patients with early-stage NSCLC. en-copyright= kn-copyright= en-aut-name=WatanabeKenta en-aut-sei=Watanabe en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KatsuiKuniaki en-aut-sei=Katsui en-aut-mei=Kuniaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SugiyamaSoichiro en-aut-sei=Sugiyama en-aut-mei=Soichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshioKotaro en-aut-sei=Yoshio en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Proton Beam Therapy, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry,and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=Clinical pathology kn-keyword=Clinical pathology en-keyword=Elderly kn-keyword=Elderly en-keyword=Non-small cell lung carcinoma kn-keyword=Non-small cell lung carcinoma en-keyword=Radiosurgery kn-keyword=Radiosurgery en-keyword=Stereotactic body radiation therapy kn-keyword=Stereotactic body radiation therapy END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1 article-no= start-page=15 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202102 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Volumetric PET Parameters Predict Prognosis after Definitive Chemoradiotherapy with Cisplatin/Docetaxel for Stage III Non-Small Cell Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of this study was to investigate whether volumetric positron emission tomography (PET) parameters are prognostic predictors in stage III non-small cell lung cancer patients receiving definitive concurrent chemo-radiotherapy (CCRT) with cisplatin/docetaxel. Cases involving definitive CCRT were reviewed retrospectively, and the maximum standardized uptake value, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated. The relationships between these PET parameters and prognosis were analyzed. MTV and TLG were significant predictors of distant metastasis-free survival (DMFS) (p = 0.0003 and 0.0005, respectively) and progression-free survival (PFS) (p = 0.001 and 0.0007, respectively). The three-year DMFS rates in patients with low and high MTV were 13.3% and 64.6%, respectively, and the corresponding values in those with low and high TLG were 13.3% and 65.2%, respectively. The three-year PFS rates in patients with low and high MTV were 13.3% and 57.8%, respectively, and the corresponding values in patients with low and high TLG were 13.3% and 57.8%, respectively. However, MTV and TLG were not predictors of local control or overall sur-vival. We demonstrated that volumetric PET parameters were predictors of patients receiving definitive CCRT. Our findings contradict the findings of previous reports and warrant further research to validate them. en-copyright= kn-copyright= en-aut-name=KatsuiKuniaki en-aut-sei=Katsui en-aut-mei=Kuniaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OgataTakeshi en-aut-sei=Ogata en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TadaAkihiro en-aut-sei=Tada en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SugiyamaSoichi en-aut-sei=Sugiyama en-aut-mei=Soichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshioKotaro en-aut-sei=Yoshio en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Proton Beam Therapy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Radiology, Iwakuni Clinical Center kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=7 en-affil=Allergy and Respiratory Medicine, Okayama University Hospital kn-affil= affil-num=8 en-affil=Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=volumetric positron emission tomography parameters kn-keyword=volumetric positron emission tomography parameters en-keyword=distant metastasis-free survival kn-keyword=distant metastasis-free survival en-keyword=chemoradiotherapy kn-keyword=chemoradiotherapy en-keyword=cisplatin/docetaxel kn-keyword=cisplatin/docetaxel en-keyword=non-small cell lung cancer kn-keyword=non-small cell lung cancer END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1 article-no= start-page=9 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202102 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Needle Tract Ablation in Liver Tissue Using a Cryoprobe Combined with an Electrosurgical Device: Influence of ex vivo and in vivo Animal Models en-subtitle= kn-subtitle= en-abstract= kn-abstract=To assess the feasibility of needle tract ablation in liver tissue in ex vivo and in vivo animal models using a cryo-probe and electrosurgical device. The experimental device is made by inserting a cryoprobe through an intro-ducer sheath for insulation, with 2-cm of probe tip projecting out. A beagle liver was punctured by the device, and electric current was applied at 30-W with the electrosurgical knife touching the non-insulated device base. The discolored area of cut surface along the device was evaluated in 5 application-time groups (5 , 10 , 15 , 20, or 25 seconds). An ex vivo experiment was performed to determine an ablation algorithm with an appropriate application time by comparison with radiofrequency ablation (RFA) results. Thereafter, an in vivo experiment was performed to verify the algorithm’s feasibility. In the ex vivo model, the cut surface demonstrated different amounts of discolored area according to the application time. The total discolored area in the 20-seconds group was similar to that by RFA. In the in vivo model, the liver did not bleed, the total discolored area was similar to that ex vivo, and coagulation necrosis was confirmed by photomicrograph. Needle tract ablation can be per-formed using the experimental device and electrosurgical device. en-copyright= kn-copyright= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamotoAkira en-aut-sei=Yamamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KomakicToshiyuki en-aut-sei=Komakic en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitayamaToshiaki en-aut-sei=Kitayama en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakuraiJun en-aut-sei=Sakurai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TomitaKoji en-aut-sei=Tomita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Division of Medical Informatics, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Otemae Hospital kn-affil= affil-num=5 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=needle tract ablation kn-keyword=needle tract ablation en-keyword=cryoablation kn-keyword=cryoablation en-keyword=electrosurgical device kn-keyword=electrosurgical device en-keyword=animal kn-keyword=animal en-keyword=liver kn-keyword=liver END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=5 article-no= start-page=443 end-page=448 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Combined Laparoscopic and CT Monitoring of the Ice-Ball Margin during Cryoablation for Renal Cell Carcinoma Associated with von Hippel-Lindau Disease: First Case en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a 47-year-old Japanese female with 10 previous treatments for multiple bilateral renal cell carcinoma (RCC) associated with von Hippel-Lindau disease. The 14-mm right lower pole renal tumor was in contact with the right ureter. Laparoscopic cryoablation was performed to protect the ureter wrapped with gauze. Computed tomography (CT) monitoring was used to confirm the precise ≥ 6 mm ice-ball margin. There was no local progression at 6-months post-surgery. The serum creatinine has been stable. This is apparently the first report of combined laparoscopic and CT monitoring of an ice-ball formation and its margin during cryoablation for RCC. en-copyright= kn-copyright= en-aut-name=SekitoTakanori en-aut-sei=Sekito en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KomakiToshiyuki en-aut-sei=Komaki en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KatayamaSatoshi en-aut-sei=Katayama en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YoshinagaKasumi en-aut-sei=Yoshinaga en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WatariShogo en-aut-sei=Watari en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MaruyamaYuki en-aut-sei=Maruyama en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MitsuiYosuke en-aut-sei=Mitsui en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KubotaRisa en-aut-sei=Kubota en-aut-mei=Risa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=WadaKoichiro en-aut-sei=Wada en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=TakamotoAtsushi en-aut-sei=Takamoto en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=SakoTomoko en-aut-sei=Sako en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=KobayashiYasuyuki en-aut-sei=Kobayashi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=WatanabeToyohiko en-aut-sei=Watanabe en-aut-mei=Toyohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=16 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=17 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=18 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=19 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=20 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=21 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=22 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=23 en-affil= Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=laparoscopic cryoablation kn-keyword=laparoscopic cryoablation en-keyword=multiple renal masses kn-keyword=multiple renal masses en-keyword=nephron-sparing surgery kn-keyword=nephron-sparing surgery en-keyword=renal cell carcinoma kn-keyword=renal cell carcinoma en-keyword=von Hippel-Lindau disease kn-keyword=von Hippel-Lindau disease END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=8 article-no= start-page=5096 end-page=5101 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Radiation therapy for oligometastatic bone disease in breast cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=Breast cancer (BCa) frequently metastasizes to the bone. BCa patients with oligometastatic bone diseases have much more favorable outcomes than those with metastatic bone disease. Radiation therapy (RT), especially stereotactic body radiation therapy (SBRT), is advised for the treatment of patients with oligometastatic bone disease in other primary sites. "This line of treatment provided favorable outcomes in patients and resulted in only mild toxicities. A similar strategy has been suggested for treatment of BCa patients with oligometastatic bone disease. BCa, bone-only, or high radiation dose are reported to have been associated with good outcomes in RT for metastatic disease. Furthermore, based on the guidelines provided by the BCa expert panel of the German Society for Radiation Oncology and members of the Working Party of Gynecologic Oncology Breast Committee and in line of the results obtained in other primary sites, our group supports the use of high-dose RT or SBRT for the treatment of BCa patients with oligometastatic bone disease. Additionally, the use of magnetic resonance imaging (MRI) for proper target volume definition and three-dimensional (3D) treatment planning especially for lesions of the trunk are essential for the treatment planning of RT. Of note, several clinical trials have combined RT with immune checkpoint inhibitors for the treatment of BCa patients with metastatic disease. Based on this, we anticipate that combined RT and ICI may serve as a better treatment modality for BCa patients with oligometastatic bone disease. en-copyright= kn-copyright= en-aut-name=KatayamaNorihisa en-aut-sei=Katayama en-aut-mei=Norihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KatsuiKuniaki en-aut-sei=Katsui en-aut-mei=Kuniaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WatanabeKenta en-aut-sei=Watanabe en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NagaoRyota en-aut-sei=Nagao en-aut-mei=Ryota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OtsukiKaho en-aut-sei=Otsuki en-aut-mei=Kaho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Medical School kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Medical School kn-affil= en-keyword=Bone metastasis kn-keyword=Bone metastasis en-keyword=breast cancer (BCa) kn-keyword=breast cancer (BCa) en-keyword=oligometastatic kn-keyword=oligometastatic en-keyword=radiation therapy (RT) kn-keyword=radiation therapy (RT) en-keyword=stereotactic body radiation therapy (SBRT) kn-keyword=stereotactic body radiation therapy (SBRT) END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=3 article-no= start-page=209 end-page=214 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202006 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Clinical Study Evaluating an Aspiration-type Semi-Automatic Cutting Biopsy Needle (SCIRO-1702) en-subtitle= kn-subtitle= en-abstract= kn-abstract=An aspiration-type semi-automatic cutting biopsy needle enables tissue cutting during application of negative pressure, which is expected to contribute to a larger amount of specimen. The aim of the present study was to evaluate this novel needle in a clinical setting. Patients who underwent image-guided percutaneous biopsy for lung or renal masses were enrolled. Cutting biopsy was performed with and without aspiration during each procedure. The specimens were weighed using an electronic scale. The weights were compared between specimens obtained with and without aspiration using a paired t-test. The data from 45 lung and 30 renal biopsy procedures were analyzed. In lung biopsy, the mean±standard deviation weights of specimens obtained with and without aspiration were 2.20±1.05 mg and 2.24±1.08 mg, respectively. In renal biopsy, the mean weights were 6.52±2.18 mg and 6.42±1.62 mg, respectively. The weights were not significantly different between specimens obtained with and without aspiration either in lung (p=0.799) or renal (p=0.789) biopsies. The application of negative pressure with the aspiration-type semi-automatic cutting biopsy needle did not contribute to an increase in the amount of the specimen obtained in lung and renal biopsies. en-copyright= kn-copyright= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakuraiJun en-aut-sei=Sakurai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MasaokaYoshihisa en-aut-sei=Masaoka en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Center for Innovative Clinical Medicine kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Division of Medical Informatics, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=biopsy kn-keyword=biopsy en-keyword=cutting needle kn-keyword=cutting needle en-keyword=aspiration kn-keyword=aspiration en-keyword=clinical study kn-keyword=clinical study END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Radiation pneumonitis after definitive concurrent chemoradiotherapy with cisplatin/docetaxel for non-small cell lung cancer: Analysis of dose-volume parameters en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Radiation pneumonitis (RP) is a major pulmonary adverse event of chest radiotherapy. The PACIFIC trial that identified durvalumab as an effective subsequent-line therapy after concurrent chemoradiotherapy (CCRT) found that patients with grade 2 or higher RP may have to be excluded from treatment under certain criteria. The purpose of this study was to investigate the relationship between grade ≥2 RP and the parameters of dose-volume histograms after CCRT with cisplatin/docetaxel for stage III non-small cell lung cancer and conduct a subset analysis of severe RP that can lead to the permanent discontinuation of treatment per the PACIFIC trial criteria to help determine treatment strategy.
Methods: We calculated the percentage of the lung volume received at least 5 Gy (V5) and 20 Gy (V20), the mean lung dose (MLD), and the lung volume spared from a 5 Gy dose (VS5) to the total lung volume. Factors affecting the incidence of grade ≥2 RP were identified; severe RP was defined as grade ≥3 as well as grade 2 RP that required ≥10 mg prednisolone for at least 12 weeks.
Results: This study included 45 patients. On univariate analysis, all parameters and total lung volume were found to be significant predictors of grade ≥2 RP (P = .001, .003, .03, .004, and .02, respectively). On multivariate analysis, V20 was a significant predictive factor of grade ≥2 RP (P = .007). Severe RP developed in 6 of 37 patients (16.2%) whose V20 values were 35% or lower. On univariate analysis, only V20 was a significant predictor of severe RP in these patients (P = .01).
Conclusions: The best approach to reduce the rate of grade ≥2 RP is to maintain the V5, V20, MLD, and VS5 as low as possible during radiotherapy planning in patients receiving definitive CCRT with cisplatin/docetaxel. en-copyright= kn-copyright= en-aut-name=KatsuiKuniaki en-aut-sei=Katsui en-aut-mei=Kuniaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OgataTakeshi en-aut-sei=Ogata en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WatanabeKenta en-aut-sei=Watanabe en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KatayamaNorihisa en-aut-sei=Katayama en-aut-mei=Norihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Proton Beam Therapy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=2 en-affil=Department of Radiology, Iwakuni Clinical Center kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=8 en-affil=Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=9 en-affil=Departments of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=10 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= en-keyword=cisplatin kn-keyword=cisplatin en-keyword=docetaxel kn-keyword=docetaxel en-keyword=dose-volume histogram kn-keyword=dose-volume histogram en-keyword=non-small cell lung cancer kn-keyword=non-small cell lung cancer en-keyword=PACIFIC trial kn-keyword=PACIFIC trial en-keyword=radiation pneumonitis kn-keyword=radiation pneumonitis END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=2 article-no= start-page=129 end-page=135 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association between Histological Types and Enhancement of Dynamic CT for Primary Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal–Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types. en-copyright= kn-copyright= en-aut-name=FukumaShogo en-aut-sei=Fukuma en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShinyaTakayoshi en-aut-sei=Shinya en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SohJunichi en-aut-sei=Soh en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukuharaRyuichiro en-aut-sei=Fukuhara en-aut-mei=Ryuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OgawaNanako en-aut-sei=Ogawa en-aut-mei=Nanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HigakiFumiyo en-aut-sei=Higaki en-aut-mei=Fumiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IchiharaEiki en-aut-sei=Ichihara en-aut-mei=Eiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Pediatric Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama City General Medical Center kn-affil= affil-num=7 en-affil=Department of Pathology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Radiology, Okayama University Hospital kn-affil= en-keyword=differentiation kn-keyword=differentiation en-keyword=dynamic computed tomography kn-keyword=dynamic computed tomography en-keyword=primary lung cancer kn-keyword=primary lung cancer en-keyword=enhancement pattern kn-keyword=enhancement pattern END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=2 article-no= start-page=123 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly. en-copyright= kn-copyright= en-aut-name=FukuharaRyuichiro en-aut-sei=Fukuhara en-aut-mei=Ryuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShinyaTakayoshi en-aut-sei=Shinya en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FukumaShogo en-aut-sei=Fukuma en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OgawaNanako en-aut-sei=Ogawa en-aut-mei=Nanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MasaokaYoshihisa en-aut-sei=Masaoka en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MarunakaHidenori en-aut-sei=Marunaka en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AriokaTadashi en-aut-sei=Arioka en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KajiMitsumasa en-aut-sei=Kaji en-aut-mei=Mitsumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=6 en-affil=Department of Pathology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=7 en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=9 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=10 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=11 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= en-keyword=18F-fluorodeoxyglucose positron emission tomography/computed tomography kn-keyword=18F-fluorodeoxyglucose positron emission tomography/computed tomography en-keyword=extranodular spread kn-keyword=extranodular spread en-keyword=metastasis kn-keyword=metastasis en-keyword=oral squamous cell carcinoma kn-keyword=oral squamous cell carcinoma END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=6 article-no= start-page=755 end-page=758 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Imaging an intrapulmonary solitary fibrous tumor with CT and F-18 FDG PET/CT en-subtitle= kn-subtitle= en-abstract= kn-abstract=Intrapulmonary solitary fibrous tumors (SFTs) are extremely rare neoplasms. We report a case of an intrapulmonary SFT and describe the findings of computed tomography (CT) and F-18 fluorodeoxyglucose positron emission tomography. The case indicates that a benign intrapulmonary SFT can present as a ground-glass nodule in the early stages of disease and may appear as a well-defined, lobular, homogeneously enhanced mass with slow growth on chest CT images. To our knowledge, this is the first report describing the natural course of an intrapulmonary SFT over 16 years based on the findings of chest CT and F-18 fluorodeoxyglucose positron emission tomography/CT. en-copyright= kn-copyright= en-aut-name=ShinyaTakayoshi en-aut-sei=Shinya en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MasaokaYoshihisa en-aut-sei=Masaoka en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SandoMotohiro en-aut-sei=Sando en-aut-mei=Motohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanabeShin en-aut-sei=Tanabe en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoSoichiro en-aut-sei=Okamoto en-aut-mei=Soichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IharaHiroki en-aut-sei=Ihara en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OtaniShinji en-aut-sei=Otani en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Pediatric Radiology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of General Thoracic Surgery, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Radiology, Okayama University Hospital kn-affil= en-keyword=Solitary fibrous tumor (SFT) kn-keyword=Solitary fibrous tumor (SFT) en-keyword=Intrapulmonary kn-keyword=Intrapulmonary en-keyword=Computed tomography (CT) kn-keyword=Computed tomography (CT) END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=2 article-no= start-page=51 end-page=53 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 2017 Incentive Award of the Okayama Medical Association in General Medical Science (2017 Yuuki Prize) kn-title=平成29年度岡山医学会賞　総合研究奨励賞（結城賞） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name=平木隆夫 kn-aut-sei=平木 kn-aut-mei=隆夫 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　放射線医学 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=6 article-no= start-page=511 end-page=514 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Acute Bowel Injury due to Cryoablation for Renal Cell Carcinoma: Correlated Radiologic and Pathologic Findings en-subtitle= kn-subtitle= en-abstract= kn-abstract=An 87-year-old Japanese man underwent percutaneous cryoablation (PCA) therapy for his renal cell tumor. We displaced the colon from the tumor using hydrodissection. Computed tomography (CT) immediately after PCA was indicative of iceball extension to the colon wall, and a discontinuous enhancement of the colon wall was observed. We therefore performed an emergency surgery. On laparotomy, we observed a dark-purple area on the affected area of the colon, and the resected specimen showed focal, deep ulceration on the mucosal surface. Photomicrography revealed mucosal necrosis, submucosal hemorrhage, and necrotic foci in the muscularis propria, corresponding to the discontinuous colon wall enhancement on CT and the deep ulceration and dark-purple area on laparotomy. He recovered from surgery and was discharged without any complications. en-copyright= kn-copyright= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FujiwaraHiroyasu en-aut-sei=Fujiwara en-aut-mei=Hiroyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NagasakaTakeshi en-aut-sei=Nagasaka en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KishimotoHiroyuki en-aut-sei=Kishimoto en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Radiology,Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology,Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Radiology,Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology,Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Pathology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= en-keyword=bowel injury kn-keyword=bowel injury en-keyword=complication kn-keyword=complication en-keyword=cryoablation kn-keyword=cryoablation en-keyword=renal cell carcinoma kn-keyword=renal cell carcinoma en-keyword=thermal ablation kn-keyword=thermal ablation END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=4 article-no= start-page=317 end-page=321 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201608 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Single Center Prospective Phase II Trial of CT-guided Radiofrequency Ablation for Pulmonary Metastases from Colorectal Cancer (SCIRO-1401) en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present single center prospective phase II clinical trial is designed to evaluate the efficacy and safety of percutaneous radiofrequency (RF) ablation for colorectal lung metastases. Patients who have colorectal lung metastases without extrapulmonary metastases are included in this study. The primary endpoint is 3-year overall survival (OS) after RF ablation. The secondary endpoints are the prevalence of adverse events within 4 weeks, local tumor progression rate, 1- and 5-year OS, cause-specific survival, and relapse-free survival. The recruitment of patients commenced in July 2014, and the enrolment of 45 patients is intended over the 3 years of study period. en-copyright= kn-copyright= en-aut-name=SakuraiJun en-aut-sei=Sakurai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiwaraHiroyasu en-aut-sei=Fujiwara en-aut-mei=Hiroyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NagasakaTakeshi en-aut-sei=Nagasaka en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=Susumu KanazawaSusumu Kanazawa en-aut-sei=Susumu Kanazawa en-aut-mei=Susumu Kanazawa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Radiology, Okayama University Hospital kn-affil= en-keyword=radiofrequency ablation kn-keyword=radiofrequency ablation en-keyword=colorectal cancer kn-keyword=colorectal cancer en-keyword=lung metastasis kn-keyword=lung metastasis END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=4 article-no= start-page=303 end-page=306 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201608 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Safety of Percutaneous Cryoablation in Patients with Painful Bone and Soft Tissue Tumors: A Single Center Prospective Study (SCIRO-1502) en-subtitle= kn-subtitle= en-abstract= kn-abstract=This single center prospective study is being conducted to evaluate the safety of the cryoablation for patients with pathologically diagnosed painful bone and soft tissue tumors. Enrollment of 10 patients is planned over the 3-year recruitment period. Patients have related local pain after receiving medications or external radiation therapies will be included in this study. Cryoablation will be percutaneously performed under imaging guidance, and a temperature sensor will be used during treatment as necessary. The primary endpoint is prevalence of severe adverse events within 4 weeks after therapy. The secondary endpoint is effectiveness 4 weeks after the procedure. en-copyright= kn-copyright= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakuraiJun en-aut-sei=Sakurai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiwaraHiroyasu en-aut-sei=Fujiwara en-aut-mei=Hiroyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MasaokaYoshihisa en-aut-sei=Masaoka en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=cryoablation kn-keyword=cryoablation en-keyword=soft tissue and bone tumor kn-keyword=soft tissue and bone tumor en-keyword=pain kn-keyword=pain en-keyword=safety kn-keyword=safety END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=113 end-page=118 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Aggressive Multimodality Treatment for Advanced Rectal Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=A case of advanced rectal cancer treated by aggressive local and systemic treatment who has survived more than 7 years from initial recurrence is presented. A 55-year-old woman was diagnosed with advanced lower rectal cancer and underwent a low anterior resection with complete removal of all regional lymph nodes and total mesorectal excision. The tumor was diagnosed as a moderately differentiated adenocarcinoma, pStage IIIB (T3, N2a, M0). Twenty-six months after the initial surgery, local recurrence in the pelvis was detected by computed tomography, and total pelvic exenteration with distal sacrectomy (TPES) was performed after systemic chemotherapy with a molecular-targeted drug. Six months after the TPES, multiple lung metastases were detected. Consequently, the patient underwent radiofrequency ablation (RFA) and chemotherapy. The disease has since been controlled for 38 months. As volume control is essential for cancer treatment, it may be important to combine appropriate local therapy with systemic therapy to metastatic or recurrent sites in order to achieve much longer disease control. en-copyright= kn-copyright= en-aut-name=InadaRyo en-aut-sei=Inada en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NagasakaTakeshi en-aut-sei=Nagasaka en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ToshimaToshiaki en-aut-sei=Toshima en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoriYoshiko en-aut-sei=Mori en-aut-mei=Yoshiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KondoYoshitaka en-aut-sei=Kondo en-aut-mei=Yoshitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KishimotoHiroyuki en-aut-sei=Kishimoto en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OshiroTaihei en-aut-sei=Oshiro en-aut-mei=Taihei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KanemitsuYukihide en-aut-sei=Kanemitsu en-aut-mei=Yukihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Departments of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Departments of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Departments of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Departments of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Departments of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Departments of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Departments of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Colorectal Surgery Division, National Cancer Center Hospital affil-num=9 en-affil= kn-affil=Colorectal Surgery Division, National Cancer Center Hospital affil-num=10 en-affil= kn-affil=Departments of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=colorectal cancer kn-keyword=colorectal cancer en-keyword=recurrence kn-keyword=recurrence en-keyword=total pelvic exenteration kn-keyword=total pelvic exenteration en-keyword=radiofrequency ablation kn-keyword=radiofrequency ablation en-keyword=systemic chemotherapy kn-keyword=systemic chemotherapy END start-ver=1.4 cd-journal=joma no-vol=110 cd-vols= no-issue= article-no= start-page=29 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Proton Magnetic Resonance Spectroscopy in Patients with Migration Disorders kn-title=磁気共鳴スペクトロスコピー法による脳障害の評価 ―神経遊走障害の検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Proton Magnetic Resonance Spectroscopy (1H-MRS) can be used to detect cerebral metabolites including N-acetylaspartate (NAA)，creatine (Cr) and choline (Ch). Hence，clinical applications of this method for neuropediatric diseases can be expected. However，regarding neuronal migration disorders，there have been only a few reported studies. We therefore examined the lH-MRS in six patients with migration disorders，ages ranged from 8months to 28years 10months with a mean of 10years 10months. Investigation was performed using Magnetom H15 (Siemens) with a repetition time of 1500 msec and an echo time of 270msec. The ratio of NAA/Cr，Ch/Cr were examined. The volume of interest with the size of 2 × 2 × 2 ～ 3 × 3 × 5cm3 was chosen in the area including lesions，and a contralateral area without lesions was also investigated. Results were as follows. 1) The ratio of NAA/Cr was low in the area with lesions in all 6cases; 1.41，1.95，2.27 and 1.71 in cases with heterotopic gray matter，0.99 in one case with polymicrogyria，an d 1.30 in one case with hemimegalencephaly，contrasted with a contralataral area without lesions: 1.89， 2.89，2.87，2.55，3.26，2.03，respectively. 2) The ratio of Ch/Cr showed no consistent difference between the area including lesions and contralataral area without lesions. Our findings of a decreased NAA/Cr ratio can be inferred to reflect the decreased numbers of neuronal cell population，or reduced metabolism in the lesions. en-copyright= kn-copyright= en-aut-name=SanadaSatoshi en-aut-sei=Sanada en-aut-mei=Satoshi kn-aut-name=眞田敏 kn-aut-sei=眞田 kn-aut-mei=敏 aut-affil-num=1 ORCID= en-aut-name=AsanoTakashi en-aut-sei=Asano en-aut-mei=Takashi kn-aut-name=浅野孝 kn-aut-sei=浅野 kn-aut-mei=孝 aut-affil-num=2 ORCID= en-aut-name=OkaEiji en-aut-sei=Oka en-aut-mei=Eiji kn-aut-name=岡鍈次 kn-aut-sei=岡 kn-aut-mei=鍈次 aut-affil-num=3 ORCID= en-aut-name=KawaharaMichiko en-aut-sei=Kawahara en-aut-mei=Michiko kn-aut-name=河原道子 kn-aut-sei=河原 kn-aut-mei=道子 aut-affil-num=4 ORCID= en-aut-name=SakaeKatsumi en-aut-sei=Sakae en-aut-mei=Katsumi kn-aut-name=栄勝美 kn-aut-sei=栄 kn-aut-mei=勝美 aut-affil-num=5 ORCID= en-aut-name=HirakiNorio en-aut-sei=Hiraki en-aut-mei=Norio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=6 ORCID= en-aut-name=OhtaharaShunsuke en-aut-sei=Ohtahara en-aut-mei=Shunsuke kn-aut-name=大田原俊輔 kn-aut-sei=大田原 kn-aut-mei=俊輔 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学教育学部障害児教育講座 affil-num=2 en-affil= kn-affil=Department of Child Neurology，Okayama University Medical School affil-num=3 en-affil= kn-affil=Department of Child Neurology，Okayama University Medical School affil-num=4 en-affil= kn-affil=Department of Radiology，Okayama University Medical School affil-num=5 en-affil= kn-affil=Department of Radiology，Okayama University Medical School affil-num=6 en-affil= kn-affil=Department of Radiology，Okayama University Medical School affil-num=7 en-affil= kn-affil=Kibi International University Health Sciences School en-keyword=MR spectroscopy kn-keyword=MR spectroscopy en-keyword=migration disorder kn-keyword=migration disorder en-keyword=heterotopic gray matter kn-keyword=heterotopic gray matter en-keyword=polymicrogyria kn-keyword=polymicrogyria en-keyword=hemimegalencephaly kn-keyword=hemimegalencephaly END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=5 article-no= start-page=227 end-page=234 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Percutaneous sclerotherapy for venous malformations using polidocanol under fluoroscopy. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

This retrospective study evaluated the safety and efficacy of using polidocanol with X-ray fluoroscopy for percutaneous sclerotherapy of venous malformations of the limbs, head, and neck. The subjects were 16 of 18 patients who presented to our department with venous malformations. Two patients were excluded because they were unlikely to benefit from the treatment. Of the 16 included in the study, 1 could not be treated because of inaccessibility, and another was lost to follow-up. Among the 14 cases that we were able to follow-up, 11 cases had had pain as their primary symptom. Following treatment, this symptom remained unchanged in 1 patient, was improved in 4, and had disappeared in 6; however, there was a recurrence of pain for 3 of these patients. Two patients had sought treatment for cosmetic purposes; following treatment, the lesion disappeared in one and showed a significant reduction in the other. The remaining patient presented with a primary symptom of mouth bleeding, which disappeared following treatment. There were no critical complications. Percutaneous sclerotherapy of venous malformations using polidocanol is safe and effective, and permits repeat treatments. The efficacy is especially good for resolving pain, and complications are minor. It is desirable to use fluoroscopy for these procedures

en-copyright= kn-copyright= en-aut-name=MimuraHidefumi en-aut-sei=Mimura en-aut-mei=Hidefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasuiKotaro en-aut-sei=Yasui en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FujiwaraHiroyasu en-aut-sei=Fujiwara en-aut-mei=Hiroyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HyodoTsuyoshi en-aut-sei=Hyodo en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MukaiTakashi en-aut-sei=Mukai en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=DendoShuichi en-aut-sei=Dendo en-aut-mei=Shuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KoshimaIsao en-aut-sei=Koshima en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University affil-num=10 en-affil= kn-affil=Okayama University affil-num=11 en-affil= kn-affil=Okayama University en-keyword=venous malformation kn-keyword=venous malformation en-keyword=sclerotherapy kn-keyword=sclerotherapy en-keyword=polidocanol kn-keyword=polidocanol en-keyword=fluoroscopy guidance kn-keyword=fluoroscopy guidance END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=2 article-no= start-page=105 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Maximum Standardized Uptake Value Is More Reliable Than Size Measurement in Early Follow-up to Evaluate Potential Pulmonary Malignancies Following Radiofrequency Ablation en-subtitle= kn-subtitle= en-abstract= kn-abstract=We retrospectively evaluated the accumulation of fluorodeoxy glucose (FDG) in pulmonary malignancies without local recurrence during 2-year follow-up on positron emission tomography (PET)/computed tomography (CT) after radiofrequency ablation (RFA). Thirty tumors in 25 patients were studied (10 non-small cell lung cancers;20 pulmonary metastatic tumors). PET/CT was performed before RFA, 3 months after RFA, and 6 months after RFA. We assessed the FDG accumulation with the maximum standardized uptake value (SUVmax) compared with the diameters of the lesions. The SUVmax had a decreasing tendency in the first 6 months and, at 6 months post-ablation, FDG accumulation was less affected by inflammatory changes than at 3 months post-RFA. The diameter of the ablated lesion exceeded that of the initial tumor at 3 months post-RFA and shrank to pre-ablation dimensions by 6 months post-RFA. SUVmax was more reliable than the size measurements by CT in the first 6 months after RFA, and PET/CT at 6 months post-RFA may be more appropriate for the assessment of FDG accumulation than that at 3 months post-RFA. en-copyright= kn-copyright= en-aut-name=AlafateAierken en-aut-sei=Alafate en-aut-mei=Aierken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShinyaTakayoshi en-aut-sei=Shinya en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkumuraYoshihiro en-aut-sei=Okumura en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatoShuhei en-aut-sei=Sato en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IshiiHiroaki en-aut-sei=Ishii en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KatoKatsuya en-aut-sei=Kato en-aut-mei=Katsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MiyoshiShinichiro en-aut-sei=Miyoshi en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KajiMitsumasa en-aut-sei=Kaji en-aut-mei=Mitsumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Diagnostic Radiology & Interventional Radiology, Fukuyama City Hospital affil-num=4 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of General Thoracic Surgery and Breast and Endocrinologica Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=11 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=12 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=fluorodeoxy glucose (FDG) kn-keyword=fluorodeoxy glucose (FDG) en-keyword=positron emission tomography (PET) kn-keyword=positron emission tomography (PET) en-keyword=standardized uptake value (SUV) kn-keyword=standardized uptake value (SUV) en-keyword=radiofrequency ablation (RFA) kn-keyword=radiofrequency ablation (RFA) en-keyword=non-small cell lung cancer (NSCLC) kn-keyword=non-small cell lung cancer (NSCLC) END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=3 article-no= start-page=375 end-page=381 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920620 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=2D-Time of Flight MR Angiography in Intrathoracic Masses kn-title=胸部腫瘤性病変における2D-Time of Flight MR Angiography en-subtitle= kn-subtitle= en-abstract=MR Angiography of the thorax was performed in 5 healthy volunteers and 15 patients with intrathoracic masses. 2D-MRA was obtained sequentially by means of a fast low angle shot(FLASH)technique(TR=20msec.TE=8msec, Flip angle=30within a 6-second period of breath holding. MRA for great vessels was successfully completed in all volunteers and all patients. The relation between tumor and vasculature can be visualized so definitely that MRA may be thought to be a promising complement to MR imaging in the evaluation of intrathoracic masses. kn-abstract=正常ボランティア5例, 胸部腫瘤性病変の患者15例に対してMR Angiographyを施行した.MRAは, 6秒の息、止めでFLASH法(TR=20msec, TE=8msec, Flip angle=30°)を用いて撮像した像から作成した.全ての症例で胸部大動脈, 上大静脈, 下大静脈, 肺動脈及び肺静脈根部など太い血管の明瞭なMRA像が得られ, 腫瘤とそれら大血管系との関係が把握しやすく胸部腫瘤性病変の評価に有用と考えられた. en-copyright= kn-copyright= en-aut-name=MitaniMasahiko en-aut-sei=Mitani en-aut-mei=Masahiko kn-aut-name=三谷政彦 kn-aut-sei=三谷 kn-aut-mei=政彦 aut-affil-num=1 ORCID= en-aut-name=TogamiIzumi en-aut-sei=Togami en-aut-mei=Izumi kn-aut-name=戸上泉 kn-aut-sei=戸上 kn-aut-mei=泉 aut-affil-num=2 ORCID= en-aut-name=KitagawaTakahiro en-aut-sei=Kitagawa en-aut-mei=Takahiro kn-aut-name=北川尚広 kn-aut-sei=北川 kn-aut-mei=尚広 aut-affil-num=3 ORCID= en-aut-name=KatohKatsuya en-aut-sei=Katoh en-aut-mei=Katsuya kn-aut-name=加藤勝也 kn-aut-sei=加藤 kn-aut-mei=勝也 aut-affil-num=4 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name=金澤右 kn-aut-sei=金澤 kn-aut-mei=右 aut-affil-num=5 ORCID= en-aut-name=JojaIkuo en-aut-sei=Joja en-aut-mei=Ikuo kn-aut-name=上都郁夫 kn-aut-sei=上都 kn-aut-mei=郁夫 aut-affil-num=6 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=7 ORCID= en-aut-name=AndoAkio en-aut-sei=Ando en-aut-mei=Akio kn-aut-name=安藤陽夫 kn-aut-sei=安藤 kn-aut-mei=陽夫 aut-affil-num=8 ORCID= en-aut-name=ShimizuNobuyoshi en-aut-sei=Shimizu en-aut-mei=Nobuyoshi kn-aut-name=清水信義 kn-aut-sei=清水 kn-aut-mei=信義 aut-affil-num=9 ORCID= en-aut-name=TeramotoShigeru en-aut-sei=Teramoto en-aut-mei=Shigeru kn-aut-name=寺本滋 kn-aut-sei=寺本 kn-aut-mei=滋 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=岡山大学 affil-num=7 en-affil= kn-affil=岡山大学 affil-num=8 en-affil= kn-affil=岡山大学 affil-num=9 en-affil= kn-affil=岡山大学 affil-num=10 en-affil= kn-affil=岡山大学 en-keyword=MRA kn-keyword=MRA en-keyword=2D-Time of Flight method kn-keyword=2D-Time of Flight method en-keyword=Intrathoracic masses kn-keyword=Intrathoracic masses en-keyword=Lung cancer kn-keyword=Lung cancer END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=6 article-no= start-page=395 end-page=402 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Usefulness of Pre-Radiofrequency Ablation SUVmax in 18F-FDG PET/CT to Predict the Risk of a Local Recurrence of Malignant Lung Tumors after Lung Radiofrequency Ablation en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of the present study was to assess the diagnostic usefulness of Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in the prediction of local recurrence of malignant lung tumors by analyzing the pre-radiofrequency ablation (RFA) maximal standardized uptake value (SUVmax). We performed a historical cohort study of consecutive malignant lung tumors treated by RFA from January 2007 to May 2008 at Okayama University Hospital. We selected only lung tumors examined by PET/CT within 90 days before RFA and divided them (10 primary and 29 metastatic) into 3 groups according to their tertiles of SUVmax. We calculated recurrence odds ratios in the medium group and the high group compared to the low group using multivariate logistic analysis. After we examined the relationship between SUVmax and recurrence in a crude model, we adjusted for some factors. Tumors with higher SUVmax showed higher recurrence odds ratios (medium group;1.84, high group;4.14, respectively). The tumor size also increased the recurrence odds ratio (2.67);we thought this was mainly due to selection bias because we excluded tumors less than 10mm in diameter. This study demonstrated the pre-RFA SUVmax in PET/CT may be a prognostic factor for local recurrence of malignant lung tumors. en-copyright= kn-copyright= en-aut-name=HaradaSosuke en-aut-sei=Harada en-aut-mei=Sosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SatoShuhei en-aut-sei=Sato en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuzukiEtsuji en-aut-sei=Suzuki en-aut-mei=Etsuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkumuraYoshihiro en-aut-sei=Okumura en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MimuraHidefumi en-aut-sei=Mimura en-aut-mei=Hidefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KajiMitsumasa en-aut-sei=Kaji en-aut-mei=Mitsumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Okayama Diagnostic Imaging Center affil-num=10 en-affil= kn-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=fluorodeoxyglucose (FDG) kn-keyword=fluorodeoxyglucose (FDG) en-keyword=positron emission tomography (PET) kn-keyword=positron emission tomography (PET) en-keyword=standardized uptake value (SUV) kn-keyword=standardized uptake value (SUV) en-keyword=radiofrequency ablation (RFA) kn-keyword=radiofrequency ablation (RFA) en-keyword=lung kn-keyword=lung END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=5 article-no= start-page=287 end-page=297 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Radiofrequency Ablation of Lung Cancer at Okayama University Hospital: A Review of 10 Years of Experience en-subtitle= kn-subtitle= en-abstract= kn-abstract=The application of radiofrequency ablation for the treatment of lung cancer by our group at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences began in June 2001, and in the present report, we review our 10-year experience with this treatment modality at Okayama University Hospital. The local efficacy of radiofrequency ablation for the treatment of lung cancer depends on tumor size and the type of electrode used, but not on tumor type. An important factor for the prevention of local failure may be the acquisition of an adequate ablative margin. The combination of embolization and radiation therapy enhances the local efficacy. Local failure may be salvaged by repeating the radiofrequency ablation, particularly in small tumors. Survival rates after radiofrequency ablation are quite promising for patients with clinical stage I non-small cell lung cancer and pulmonary metastasis from colorectal cancer, hepatocellular carcinoma, and renal cell carcinoma. The complications caused by radiofrequency ablation can be treated conservatively in the majority of cases. However, attention should be paid to rare but serious complications. This review shows that radiofrequency ablation is a promising treatment for patients with lung cancer. en-copyright= kn-copyright= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MimuraHidefumi en-aut-sei=Mimura en-aut-mei=Hidefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiwaraHiroyasu en-aut-sei=Fujiwara en-aut-mei=Hiroyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YasuiKotaro en-aut-sei=Yasui en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SanoYoshifumi en-aut-sei=Sano en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SakuraiJun en-aut-sei=Sakurai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TajiriNobuhisa en-aut-sei=Tajiri en-aut-mei=Nobuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MukaiTakashi en-aut-sei=Mukai en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Diagnostic Radiology, National Cancer Center Hospital affil-num=6 en-affil= kn-affil=Department of Radiology, Okayama Saiseikai General Hospital affil-num=7 en-affil= kn-affil=Department of Thoracic Surgery, Ehime University Hospital affil-num=8 en-affil= kn-affil=Department of Diagnostic Radiology and Interventional Radiology, Fukuyama City Hospital affil-num=9 en-affil= kn-affil=Department of Radiology, Kagawa Prefectural Central Hospital affil-num=10 en-affil= kn-affil=Department of Radiology, Mitoyo General Hospital affil-num=11 en-affil= kn-affil=Department of Radiology, Okayama Medical Center affil-num=12 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=13 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=radiofrequency ablation kn-keyword=radiofrequency ablation en-keyword=lung cancer kn-keyword=lung cancer en-keyword=local efficacy kn-keyword=local efficacy en-keyword=survival kn-keyword=survival en-keyword=complication kn-keyword=complication END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=10 suppl article-no= start-page=49 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=著しく遷延せる日本脳炎の一治験例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=長田高寿 kn-aut-sei=長田 kn-aut-mei=高寿 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木山敦麿 kn-aut-sei=木山 kn-aut-mei=敦麿 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=内田豊 kn-aut-sei=内田 kn-aut-mei=豊 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=方円幸彦 kn-aut-sei=方円 kn-aut-mei=幸彦 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=10 suppl article-no= start-page=25 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=AN EPIDEMIOLOGICAL OBSERVATION OF JAPANESE B ENCEPHALITIS PREVAILED OVER OKAYAMA PREFECTURE DURING THE PAST 8 YEAR FROM 1946 TILL 1953 kn-title=昭和21ー28年間，岡山県下に流行せる日本脳炎の疫学的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=From the epidemiological point of view, an observation was made on the features of Japanese B encephalitis, which occurred and prevailed in Okayama Prefecture, where the outbreak of this disease has been reported all these 8 years from 1946 till 1953. Almost every year, the number of patients in this prefecture exceeded the average one of the whole country. In addition, it seemed to indicate serious outbreak with the period of about 10 years. Every outbreak has taken place between mid-August and early September. Both children and aged people were susceptible to this disease, the mortality being low in children and somewhat high in the aged patients. Male patients were more numerous than female patients. It is interesting to note that, when the local origin of the patients was investigated, it appeared that many children patients were of the southern parts of the prefecture and many aged patients of the northern parts, where the mortality caused by the disease is somewhat higher. Further investigation in this respect will be done in the future. The peak of this disease was usually seen to be reached in the south about two weeks earlier than in the north. Thus it may well be said that the features of the prevalence of this disease have an intimate relation with the climatic condition. The differential diagnosis of this disease was found to be difficult when accompanied with tuberculolus meningitis, ekiri, dysentery and some other disease with encephalitic or meningitic symptom. en-copyright= kn-copyright= en-aut-name=UchidaYutaka en-aut-sei=Uchida en-aut-mei=Yutaka kn-aut-name=内田豊 kn-aut-sei=内田 kn-aut-mei=豊 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=10 suppl article-no= start-page=1 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EXPERIMENTAL STUDIES ON JAPANESE B ENCEPHALITIS. 1. HAEMOGRAMS OF THE MICE INFECTED WITH JAPANESE B ENCEPHALITIS AND THE EFECTS OF RADIOACTVE P(32) ADMINISTRATION kn-title=日本脳炎に関する実験的研究 第一報 日本脳炎罹患マウスの血液像，特にそれに及ぼす放射性同位元素P(32)の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Comparative studies on the haemograms of the mice infected with Japanese B encephalitis with or without the administration of radioactive P(32) were made. 1. In the haemogram of the infected mouse a decrease in the number of white blood cells was observed along with the duration, although there occurred no appreciable amount of changes in the numbers of red blood cells and reticulocytes and in the quantity of haemoglobin. This drop in the number of while blood cells was especially remarkable during the infection period. The classification of the white blood cells showed an increase in the percentage of neutrophilic leucocytes and a decrease in the absolute number of lymphocytes. 2. The administration of radio active P(32) to the normal mouse caused some haemogramaberrations, proportional to the amounts of doses: When 30 μc. p(32) was given, the numbers of red blood cells and reticulocytes and ihe quantity of haemogIobin remaining the same as usual, the number of white blood cells showed a considerable decrease, its minimum value appearing 4 or 5 days after the admininistration. 40 μc. dose gave rise to a slight decrease in the numbers of red blood.cells and reticuloocytes and in the quantity of haemoglobin, the decrease in white blood cell number being far more remarkable than that caused by 30 μc. administration. In both of these two cases, the increases in the percentage of neutrophilic leucocytes and the decreases in the absolute number of lymphocytes were also observed. 3. 30 μc. P(32) administration to the infected mouse induced no significant changes in the numbers of red blood cells and reticulocytes and in the quantity of haemo gIobin, but the number of leucocytcs showed a more marked decrease than that of the infected mouse with no P(32) administration, the increase in the percentage of neutrophilic leucocytes having been depressed. In addition, the elongation of the latent period for Encephalitis of the mice were recognized. en-copyright= kn-copyright= en-aut-name=HoenYukihiko en-aut-sei=Hoen en-aut-mei=Yukihiko kn-aut-name=方円幸彦 kn-aut-sei=方円 kn-aut-mei=幸彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=10 article-no= start-page=2793 end-page=2808 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19351031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Über einen im Verlauf von Typhus abdominalis die Mediastinalblutung berufenden Fall kn-title=腸「チフス」ノ經過中ニ縱隔竇出血ヲ起セシ1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser berichten eine äusserst seltene Mediastinalblutung als Komplikation des Typhus abdominalis; ein gleicher, zumindest ein ähnlicher Fall war uns in der Literatur nicht begegnet. Der Kranke war ein 24-jähriger Mann. Seit Anfang Oktober 1934 Klagte er über Kopfschmerz, allgemeine Mattigkeit, Appetitlosigkeit und Husten, am 9 ten des Monates trat Schüttelfrost mit hohem Fieber auf. Er wurde auf die Diagnose Typhus abdominalis hin sofort aufgenommen. Im Krankenbett verlief die Erkrankung als schwere Form: Puls von Anfang an beschleunigt, Zunge fuliginös dick belegt, Stuhlgang anfänglich zur Verstopfung neigend, aber bald darauf diarrhoeisch, vorläufige subikterische Verfärbung an den Conj. Bulbi und Ende Oktober Auftreten von Darmblutung. Anfang November begaun das bisher hohe Kontinua-Fieber zu remittieren, und man glaubte schon an eine Genesung. Aber am 13 ten des Monates (am 42 ten Krankheitstag) trat sehr früh am Morgen plötzlich in der Epigastrialgegend und an beiden Schultern ein ausstrahlender heftiger Schmerz auf. Der Patient fiel sofort unter Schreien in Kollapszustand; nach der Injektion von Herzmitteln schien er sich zu erholen, doch am Abend desselben Tages, um 8 Uhr, starb er schliesslich bei einem gleichen Anfall, trotz aller symptomatischen Behandlungen wie Injektion von Herzmitteln, Bluttransfusion usw. Die Sektionsbefunde erwiesen, dass alle diese Symptome durch die Mediastinalblutung als äusserst seltene Komplikation des Typhus abdominalis bedingt waren. en-copyright= kn-copyright= en-aut-name=HirakiKiyosi en-aut-sei=Hiraki en-aut-mei=Kiyosi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=KatuyamaSakae en-aut-sei=Katuyama en-aut-mei=Sakae kn-aut-name=勝山榮 kn-aut-sei=勝山 kn-aut-mei=榮 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學柿沼内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學柿沼内科教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=10 article-no= start-page=2197 end-page=2209 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19411031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Klinisches Bild einer familiären Eosinophilie und Überblick über die japanische Literatur kn-title=家族性「エオジン」嗜好白血球増多症 (familiäre Eosinophilie) 例竝ニ本邦文獻ニ關スル展望 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bei einem Pat., dem im Frühling 1940 eine Geschwulst des rechten Hodens exstirpiert und durch histologische Untersuchungen die Diagnose Seminom gestellt worden war, wuchsen neulich in den retroperitonealen Lymphdrüsen Metastasen heran. Der Verf. untersuchte wiederholt die Faeces und den Duodenalsaft des Pat., konnte aber darin keine Parasiteneier nachweisen. Es liess sich jedoch eine Eosinophilie feststellen. Die eosinophilen Zellen betrugen etwa 10 proz. der gesamten weissen Zellen. Die Zahl des Hämoglobins, der Erythrozyten und der Leukozyten sowie die Grösse der Erythrozyten waren normal. Die Anisocytose und Poikilocytose waren night vorhanden. Die Wassermannsche Reaktion fiel negativ aus; die Gerinnungszeit des Blutes war normal. Die Blutungszeit indes verzögerte etwas, die Retikulozyten und Blutplättchen waren an Menge einigermassen herabgesetzt. Das Aschnersche Zeichen und der Tschermaksche Versuch verliefen negativ. Bei den Familienmitgliedern des Pat. wurden in Faeces auch keine Parasiteneier beobachtet. Trotzdem fand sich beim Vater eine 16,6 proz., bei der Schwester eine 15,0 proz., beim Bruder eine 21,2 proz. und beim ersten Sohn eine 9,8 proz. Eosinopnilie. Bei den allen jedoch waren die Menge des Hämoglobins, die Zahl der Erythrozyten und der Leukozyten und die Grösse der Erythrozyten normal. Es wurden auch weder Anisocytose noch poikilocytose beobachtet; die Wassermannsche Reaktion verhielt sich negativ. Das Aschnersche Zeichen und der Tschermaksche Versuch fielen bei den Familienmitgliedern, mit Ausnahme des ersten Sohnes, negativ aus; die Vagotonie war nicht nachweislich. Aus der Summe dieser Feststellungen schliesst der Verf., dass es sich um eine sog. familiäre Eosinophilie handelte. Zu beachten ist es, dass in dem vorliegenden Fall die Eosinophilie durch Rontgenbestrahlung allmählich gesteigert wurde und dass sich in den sämtlichen Fällen Lymphocytose zeigte. Schliesslich verfolgte der Verf. in der japanischen Literatur Angaben über die familiäre Eosinophilie und fand darin 6 Referenten, die über insgesamt 26 Patienten berichteten, Diese Berichte hat er in einer Tabelle zusammengefasst, um die Gesamtergebnisse anschaulich wiederzugeben und zu besprechen. In diesen Angaben aber fanden sich nicht wenig Fälle, in denen Darmparasiten vorkamen und daher zweifelhaft waren, ob es sich um echte Eosinophilie handelte. en-copyright= kn-copyright= en-aut-name=HirakiKiyosi en-aut-sei=Hiraki en-aut-mei=Kiyosi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=9 article-no= start-page=1886 end-page=1898 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hlinisehe Beobachtungen über 2 Fälle von "Bradycardia hypotonica" kn-title=徐脈性低血壓症 (Bradycardia hypotonica) ノ2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Verf. beobachtete in der letzten Zeit 2 Patienten, die der von Max Herz so bezeichneten Bradycardia hypotonica entsprechen. In allgemeiner Darstellung berichtet der Verf. über die Symptome dieser Krankheit in Berücksichtigung aller von anderen Autoren angegebenen Fulle. Im I. Fall handelte es sich um einen 16 jahrigen Jungling von asthenischem Habitus; im II. kam ein 56 jahriger Mann von piknotischem Körperbau in Betracht. Die Beiden ashen ganz blase aus und klagten über Hypofunktionen sowohl geistig als such Körperlich. Durch Untersuchungen wurden die Bradykardie (beide zeigten 50 pro min.) und Hypotonie (hochstens 90mm Hg beim beiden Falle) ermittelt, obwohl organisch sich keine Veränderungen festetellen liessen. Der I. Fall litt an dem Typhus mandschuricus und wurde in die Klinik anfgenommen. Der II. klagte hauptsächlich uber ein Beklemmungsgefühl auf der Brust und wurde ambulatorisch behandelt. Bezüglich des Blutbildes wurde in den beiden Fällen festgestellt, dass der Hämoglobingehalt und die Erythrozytenzahl normal waren, während in Hinsicht auf die Arten der Leukozyten sich eine leichte Lymphozytose herausstellte. Die Eosinophilie war nicht vorhanden. An der Senkungsgeschwindigkeit der roten Blutkörperchen, ferner an der Blutungszeit sowie Blutgerinnungszeit wurde keine Abnormalität beobachtet. Der Blutzuckergehalt zeigte im I. Fall leichte Hyperglykaemie, wahrend im II. völlig normal war. An Grundumsatz war der I. Fall etwas herabgesetzt, der II. dagegen beinahe normal. Röntgenologisch untersucht, ergab der I. Fall ein an das Tropfenherz heranreichendes Bild. Im II. Fall wurde perkussorisch eine vollständig normale Herzdämpfungsfigur festgestellt. Der I. Fall zeigte beim Aschnerschen Versuch einen negativen Ausf all und war gegen das Adrenalin ziemlich empfindlich. Im II. Fall verlief nicht nur der Aschnersche, sondern auch der Tschermaksche Versuch negativ und ergab sich eine Uuterempfindlichkeit gegen das Adrenalin und eine Überempfindlichkeit gegen das Pilocarpin. Aus der Summe dieser Beobachtungen schliesst der Verf., dass es sich hier um eine von Bergmann angeführte vegatative Stigmatisierung handelt. en-copyright= kn-copyright= en-aut-name=HirakiKiyosi en-aut-sei=Hiraki en-aut-mei=Kiyosi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=7 article-no= start-page=1273 end-page=1292 dt-received= dt-revised= dt-accepted= dt-pub-year=1942 dt-pub=19420731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Über die Darstellung des Encepholitis-virus aus einen typischen sowie abortiven Kranken in der Gegend von Okayama im Jahre 1041 kn-title=昭和16年度岡山地方定型的竝ニ不全型夏季腦炎患者ヨリノ病毒證明ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Verf. berichtet über die Versuchsergebnisse der Darstellung des Virus von 2 Encephalitiskranken, die er im Sommer 1941 zu beobachten Gelegenheit hatte, sonst war keine Epidemie der Krankheiten stattgefunden. Im 1. Fall handert es sich um einen 56 jährigen Mann, bei dem die typischen Symptome der Encephalitis in die Erscheinung traten. Im 2. Fall traten die Symptome in sehr geringem Masse auf, so dass die Erkrankung als eine der sog. abortiven Form angehörige betrachtet werden musste. Es gelang dem Verf. verhältnismassig leicht, das Virus darzustellen und es zum Virus fixe zu machen, in dem er den Liquor cerebrospinalis, den er im 1. Fall am 3., im 2. Fall am 5. Krankheitstag entnommen hatte, Versuchsmäusen intracerebral verimpft hatte. Durch Untersuchungen dieser Mäuse, die durch das Impfung mit dem Virus an der Encephalitis erkrankt waren, erkannte der Verf., dass nicht nur klinische sowie histolosche Befunde, sondern auch die Ergebnisse immunologischer Untersuchungen mit den bisherigen Berichten verschiedener Autoren über die japanischen Sommerencephalitis vollständig übereinstimmten. Im Anschlnss an die Ergebnisse dieser Untersuchungen hat der Verf. ferner die verschiedenen Versuchstechnik für die Virusdarstellung kritisierend verglichen, über die abortiven Formen der Enceghalitis noch einige Besprechungen vorgenommen und betont schliesslich, dass die abortive Form der Encephalitis viel häufiger jugendliche Individuen als die Leute im hohen Alter befällt. en-copyright= kn-copyright= en-aut-name=HirakiKiyoshi en-aut-sei=Hiraki en-aut-mei=Kiyoshi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=6 article-no= start-page=1103 end-page=1120 dt-received= dt-revised= dt-accepted= dt-pub-year=1942 dt-pub=19420630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Zur Beurteilung der die Blutgerinnung hemmenden Manipulationen beim Nachweiss geringen Virusmenge im Blute bei der Encephalitis epidemica kn-title=血中ヨリ微量腦炎病毒ヲ證明スルニ際シテノ血液凝固阻止操作ニ關スル批判的檢索 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Beim Nachweies des Encephalitisvirus im Blut beabsichtigte der Verfasser zur Hemmung der Blutgerinnung an Stelle des bisher zu diesem Behuf allgemein verwendeten Heparin andere leichter erreichbaren Mittel zu setzen und hat diesbezügliche vergleichende Untersuchungen an 6 Substanzen, vom Heparin angefangen und an Hirudin, Infusum von Funori (Gloiopeltis furcata), Ammonium oxalat, Natriumcitrat und Magnesiumsulfat angestellt. Ferner hat er den Einfluss von Defibrinierung auf das virus im Blut untersucht. Dadurch kam er zu folgendem Schluss: Zuerst konnte er feststellen, dass alle oben genannten, die Blutgerinnung hemmenden Mittel mehr oder weniger virulizide Wirkung entfalten, und das eben bei Anwendung geringerer Menge der Fall ist. Auch das Blut, welches bis zu 10% mit der minimalsten und doch noch zur Hemmung der Gerinnung hinreichend wirksamen Dosis jeder obengenannten Mittel versetzt ist, besitzt die Fähigkeit, die Virulenz abzuschwächen, seine Wirkungsweise ist dabei nur graduell verschieden. Diese Tatsache nämlich, dass das zu 10% mit dem allgemein üblichen 0,1% igen Heparin versetzte Blut eine virulizide Wirkung, wenn auch in verschwindend geringem Grade, aufweist, ist gewiss für das Studium der Encephalitis epidemica, insbesondere beim Nachweiss von geringem Virus im Blut beachtenswert. Ferner stellte et fest, dass das Blut durch das Defibrinieren fast keine Verminderung an seinem Virusgehalt erfahrt. Daraus zieht der Verf. den Schluss, dass, wenn man eine geringe Menge Virus im Blut der Kranke nachgewiessen will, so muss das Blut ohne Zufügung der die Gerinnbarkeit des Blutes aufhebenden Mittel sofort nach der Entnahme den Mäusen intracerebral geimpft werden. Nur in dringenden Fällen scheint es berechtigt zu sein, durch die Defibrinierung die Gerinnbarkeit des Blutes fortfallen zu lassen. en-copyright= kn-copyright= en-aut-name=HirakiKiyosi en-aut-sei=Hiraki en-aut-mei=Kiyosi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=4 article-no= start-page=726 end-page=741 dt-received= dt-revised= dt-accepted= dt-pub-year=1942 dt-pub=19420430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Zwei Fälle der sog. flüchtigen Lungeninfiltrierung kn-title=所謂一過性肺浸潤症 (sog. flüchtige Lungeninfiltrierung) ノ2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bericht und Besprechung mit Berücksichtigung einschlägier Literatur über 2 Fälle der sog. flüchtigen Lungeninfiltrierung, die der Verf. in unserer Klinik in der letzten Zeit beobachten konnte. Der I. Fall war ein 18 jähriger Schüler, der mit grippenartigen Symptomen in Stürmischem Verlaufen erkrankt war. Das Röntgenbild lieferte auf dem mittleren und dem unteren Feld der rechten Lunge einen ausgedehnten Infiltratschatten. Im II. Fall handelte es sich um eine 16 jahrige Schülerin, die von jeher über ein geringes Fieber und Tachycardie zu klagen hatte und dann mit allgemeiner Mattigkeit allmählich erkrankt war. Beiröntgenologischer Untersuchung des letzten Falles machte sich ebenfalls ein ausgedehnter Infiltratschatten auf dem mittleren und dem unteren Feld der linken Lunge bemerkbar. In den beiden Fällen ist der Röntgenschatten jedoch, als der Verf. vor einem Monate untersuchte, nicht mehr erkennbar gewesen. Das geringe Fieber und die Tachycardie des II. Falles hingegen sind noch bestehengeblieben. Die wiederholt angestellte Mantouxsche Tuberkulin-Reaktion in wechselnden Verdünnungen fiel in den beiden Fällen jedesmal negativ aus. Daraus hat der Verf. den Schluss gezogen, dass man bezüglich des Wesens der vorliegenden Fälle an die Tuberkulose nicht mehr zu denken braucht. Was das Blutbild anbetrifft, so zeigte der I. Fall im Fruühstadium der Erkrankung eine leichte Leukozytose, aber keine Eosinophilie. Nach Ablauf ca. einen Monates kehrte die Leukozytenzahl mit dem Rücktritt der Infiltration allmählich zur Norm zurück, die eosino philen Leukozyten indes vermehrten sich auf 8,5%. Diese Vermehrung machte aber im Verlauf der Zeit einer Tendenz der Abnahme Platz und nach einem weiteren Monat verringerten sich die Leukozyten auf 6,5%, um nach ca. einem halben Monat zu 4,0%, zum normalen Wert, zuruckzükommen. Beim II. Fall war das Blutbild im Frühstadium der Erkrankung nicht bekannt. Als die Kranke ca. ein Monat nach der Erkrankung in die Klinik aufgenommen worden war, liess sich keine Eosinophilie festzustellen. Bei der Entlassung von der Klinik jedoch, die ungefähr nach weiteren anderthalben Monaten geschah, machten die eosinophilen Leukozyten 8,0% der gesamten weissen Zellen aus, was noch anderthalbe Monate nach dem Verlassen der Klinik hartnäckig fortbestand. In den beiden Fällen wurde die Kotprobe mehrere Male vorgenommen, wobei aber nicht nur keine Parsiteneier, sondern auch keine Ursache für die Eosinophilie nachgewiesen wurden. Aus dem Verlauf des Frühstadiums sowie dem Blutbild usw. schliesst der Verf., dass es sich im I. Fall in bezug auf die flüchtige Lungeninfiltrierung um atypische Pneumonie, im II. Fall um allergische Erkrankung handelt. Was aber das andauernd fortbestehende geringe Fieber und die Tachycardie des II. Falles anbelangt, so liegt die Annahme nahe, dass an diesen Erscheinungen der Hyperthyreoidismus, wenn er auch nur in geringem Masse beobachtet wurde, schuld sein muss. en-copyright= kn-copyright= en-aut-name=HirakiK. en-aut-sei=Hiraki en-aut-mei=K. kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=1 article-no= start-page=94 end-page=110 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studien uber die perkutane Immunisierung (III). Über das Auftreten von Virämie und die quantitativen Schwankungen von Virulizidin nach perkutaner Infektion bei encephalitisches Virulizidin enthaltenen Kaninchen kn-title=經膚免疫ニ關スル研究（其ノ3）腦炎中和抗體保有家兎ニ於ケル經膚感染後ノ病毒血症竝ニ中和抗體ノ消長ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Neulich stellte Takahara an den Kaninchen, die noch kein Virulizidin enthielten, die Versuche an, auf die Haut Encephalitisvirus. Ranolinsalbe aufzustreichen. Die Ergebnisse waren, dass ca. 3 Wochen danach spezifische Antikörper des Encephalitisvirus (Virulizidin) im Blut der betreffenden Kaninchen zutage traten (I. Mitteilung) und dass ferner bei den Kaninchen 24 Stunden nach der Aufstreichung der Salbe eine Virämie beobachtet wurde, welche im Lauf der Zeit allmählich an Intensität zunahm und nach Ablauf von 48 Stunden den Maximalwert erreichte, um danach wieder abzunehmen und nach Ablauf on 96 Stunden völlig zu verschwinden (II. Mitteilung). Auf Grund dieser Ergebnisse ausserte er sich dahin, dass das Virus bei den das Virulizidin nicht enthaltenen Kaninchen nicht nur die Haut hindurch in den Körper eindringen kann, sodern im Körper, wenn auch vorübergehend, in der Menge zunimmt. Der Verf. hat nun bei den Kaninchen, die das Virulizidin in grosser Menge enthielten, den gleichen Verauch angestellt, um durch die Untersuchung über die quantitativen Schwankungen des Virulizidins im Blut und uber das Auftreten der Virämie festzustellten, ob das Phänomen der Neutralisierung auch in vivo ebenso wie in vitro stattfinden kann, ob sich das Virus auch im Körper der das Virulizidin enthaltenen Kaninchen vermehren kann und welche Einflüsse das Virulizidin bei perkutaner Infektion, die der naturlichen Erkrankung am nächsten steht, auf die Viramie ausubt. Die Ergebnisse waren wie folgt: 1. Bei den Kaninchen, die im Blut Virulizidin enthalten, kommt es bisweilen vor, dass 36 (10,5%) bis zu 72 Stunden (5,5%) nach der Aufstreichung der Virussalbe die Virämie sich nachweisen lässt, welche namentlich in der 48 Stunde nach der perkutanen Applikation den hochsten Wert erreicht (positive Fälle betragen, einschlisslich zweifelhafter Fälle, 57,9%). Im Vergleich zur Angabe von Takahara bei den das Virulizidin nicht enthaltenen kaninchen sind diese Ergebnisse im Grad erheblich niedriger, so auch an positiven Fällen viel geringer. 2. Die Intensität sowie. die Positivitat der Virämie seten sich um so stärker herab, je beträchtlicher die Menge des Virulizidins zunimmt. In den Fällen nämlich, welche in grosser Menge das Virulizidin enthalten, ist die Virämie kaum mehr nachweisbar. Daraus ist zu ersehen, dass das Virulizidin auf das perkutan eindringende Virus neutralisierend einwirkt und durch Hemmung der Vermehrung des in den Kaninchenkörper eingedrungenen Virus den Auftritt der Virämie verhindert. 3. Nach der Aufstreichung der Virussalbe hat der Verf 2 Monate lang neben dem Vorgang der Virämie gleichzeitig auch die quantitativen Schwankungen des Virulizidins beobachtet. Es scheint, dass das Virulizidin im Blut 3 Tge-1 Woche, nach der kutanen Applikation vorubergehend etwas abnimmt. 4. Auf Grund der Tatsache, dass sich die Virämie gelegentlich noch immer nach-Weisen lässt, obschon das Virulizidin nur in einem geringen Grade abnimmt und daher noch zum grössten Teil im Blut erhalten bleibt, liegt die Annahme nahe, dass das Virulizidin und Virus im lebenden Organismus nicht vollig in Verbindung eingehen, sondern dass ein Teil von ihnen ohne Verbindung unbeachädigt zusammenbestehen kann. en-copyright= kn-copyright= en-aut-name=HirakiKiyoshi en-aut-sei=Hiraki en-aut-mei=Kiyoshi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=3 article-no= start-page=106 end-page=110 dt-received= dt-revised= dt-accepted= dt-pub-year=1948 dt-pub=19480731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=經口的骨髓投與に關する研究幼若「マウス」の發育並に血液像に及ぼす影響に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐久間昌章 kn-aut-sei=佐久間 kn-aut-mei=昌章 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=兒子卓 kn-aut-sei=兒子 kn-aut-mei=卓 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山科大學北山内科教室 affil-num=2 en-affil= kn-affil=岡山科大學北山内科教室 affil-num=3 en-affil= kn-affil=岡山科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=1-2 article-no= start-page=77 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1948 dt-pub=19480531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=發疹「チフス」發疹熱の簡易迅速なる新着色凝集反應に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石合亨 kn-aut-sei=石合 kn-aut-mei=亨 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=8 article-no= start-page=202 end-page=207 dt-received= dt-revised= dt-accepted= dt-pub-year=1949 dt-pub=19491031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=「腸チフス」患者297症例（自昭和2年至昭和20年當教室入院）の血液像並に血液像から見た豫後に關する統計的觀察（後編）血液像から見た豫後に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=棚橋祐作 kn-aut-sei=棚橋 kn-aut-mei=祐作 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科 affil-num=2 en-affil= kn-affil=岡山醫科大學北山内科 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=8 article-no= start-page=196 end-page=202 dt-received= dt-revised= dt-accepted= dt-pub-year=1949 dt-pub=19491031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=視神經脊髓炎に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石田收作 kn-aut-sei=石田 kn-aut-mei=收作 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=志態常也 kn-aut-sei=志態 kn-aut-mei=常也 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=3 en-affil= kn-affil=岡山醫科大學眼科教室 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=4 article-no= start-page=102 end-page=108 dt-received= dt-revised= dt-accepted= dt-pub-year=1949 dt-pub=19490531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=膓「チフス」患者297症例（自昭和2年至昭和20年當教室入院）の血液像並に血液像から見た豫後に關する統計的觀察 （前編） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=棚橋祐作 kn-aut-sei=棚橋 kn-aut-mei=祐作 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=4 article-no= start-page=99 end-page=102 dt-received= dt-revised= dt-accepted= dt-pub-year=1949 dt-pub=19490531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=「クループ」性肺炎に併發せる偶發性氣胸に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=豊田立郎 kn-aut-sei=豊田 kn-aut-mei=立郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=3 article-no= 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multiplex）の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=河田信彦 kn-aut-sei=河田 kn-aut-mei=信彦 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=唐井義樹 kn-aut-sei=唐井 kn-aut-mei=義樹 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=3 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=1-2 article-no= start-page=11 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=1949 dt-pub=19490331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=榮養失調症に關する臨床的諸統計 其の二 外地還送患者例並に全編の總括 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 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kn-aut-sei=兒子 kn-aut-mei=卓 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=3 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=3 article-no= start-page=115 end-page=119 dt-received= dt-revised= dt-accepted= dt-pub-year=1950 dt-pub=19500531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=經口的骨髓投與に關する研究「マウス」の飢餓に及ぼす影響（第2報） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=兒子卓 kn-aut-sei=兒子 kn-aut-mei=卓 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=河田信彦 kn-aut-sei=河田 kn-aut-mei=信彦 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=3 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=2 article-no= start-page=62 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=1950 dt-pub=19500228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=經口的骨髓投與に關する研究「マウス」の飢餓に及ぼす影響（第1報） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=兒子卓 kn-aut-sei=兒子 kn-aut-mei=卓 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=河田信彦 kn-aut-sei=河田 kn-aut-mei=信彦 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學北山内科教室 affil-num=3 en-affil= kn-affil=岡山醫科大學北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=4 article-no= start-page=169 end-page=174 dt-received= dt-revised= dt-accepted= dt-pub-year=1951 dt-pub=19510731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓内血液循環に關する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大學醫學部北山内科 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=12 article-no= start-page=2131 end-page=2137 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=下垂体移植及びゲルマニン治療を行へる尿崩症の3例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=須賀宏文 kn-aut-sei=須賀 kn-aut-mei=宏文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=12 article-no= start-page=2099 end-page=2102 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=良性急性非細菌性腦膜炎（化膿性型）の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=長田高寿 kn-aut-sei=長田 kn-aut-mei=高寿 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=12 article-no= start-page=2007 end-page=2014 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=術前小兒手拳大の副脾の存在を推定し得たる所謂バンチ氏病の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=久米田克哉 kn-aut-sei=久米田 kn-aut-mei=克哉 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=桑田睦之輔 kn-aut-sei=桑田 kn-aut-mei=睦之輔 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部陣内外科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=12 article-no= start-page=2001 end-page=2005 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=多發性骨髓腫（プラスモチトーム）の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=村川浩正 kn-aut-sei=村川 kn-aut-mei=浩正 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小西等 kn-aut-sei=小西 kn-aut-mei=等 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=副島哲郎 kn-aut-sei=副島 kn-aut-mei=哲郎 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=蜂谷良馬 kn-aut-sei=蜂谷 kn-aut-mei=良馬 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部津田外科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=11 article-no= start-page=1827 end-page=1834 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=惡性貧血の一治驗例 附；骨髄内ビタミンB(12)直接注入実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=上村家門 kn-aut-sei=上村 kn-aut-mei=家門 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=米谷公夫 kn-aut-sei=米谷 kn-aut-mei=公夫 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=11 article-no= start-page=1819 end-page=1825 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=稀有なる無脾腫性白栓球血病の1例に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=上村家門 kn-aut-sei=上村 kn-aut-mei=家門 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=北山稔 kn-aut-sei=北山 kn-aut-mei=稔 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岩崎一郎 kn-aut-sei=岩崎 kn-aut-mei=一郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=10 article-no= start-page=1783 end-page=1784 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=日本腦炎患者の髓液中酪酸値に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤森明良 kn-aut-sei=藤森 kn-aut-mei=明良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=10 article-no= start-page=1771 end-page=1776 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=氣管枝結石の数例に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片山茂樹 kn-aut-sei=片山 kn-aut-mei=茂樹 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=原正夫 kn-aut-sei=原 kn-aut-mei=正夫 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=国立岡山療養所 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=4 article-no= start-page=586 end-page=588 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=DD屎尿内寄生虫卵殺滅効果について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐野敏朗 kn-aut-sei=佐野 kn-aut-mei=敏朗 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=稲臣成一 kn-aut-sei=稲臣 kn-aut-mei=成一 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木村道也 kn-aut-sei=木村 kn-aut-mei=道也 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部寄生虫学教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=4 article-no= start-page=584 end-page=585 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=DDの農作物に及ぼす藥害作用並に屎尿腐熟に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木村道也 kn-aut-sei=木村 kn-aut-mei=道也 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=稲臣成一 kn-aut-sei=稲臣 kn-aut-mei=成一 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐野敏朗 kn-aut-sei=佐野 kn-aut-mei=敏朗 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=4 article-no= start-page=471 end-page=472 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=昭和25年夏の日本腦炎一屍体より分離の病毒 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大枝亘 kn-aut-sei=大枝 kn-aut-mei=亘 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部北山内科 affil-num=2 en-affil= kn-affil=岡山大学医学部北山内科 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=3 article-no= start-page=461 end-page=464 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=結核症に合併せる帶状疱疹の臨床統計觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤田正明 kn-aut-sei=藤田 kn-aut-mei=正明 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片山茂樹 kn-aut-sei=片山 kn-aut-mei=茂樹 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=3 article-no= start-page=453 end-page=461 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓の赤血球抑留並びに動員に関する實驗的研究 第四編 骨髓内赤血球抑留並びに動員時に於ける家兎骨髓造血像の観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤田正明 kn-aut-sei=藤田 kn-aut-mei=正明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=3 article-no= start-page=447 end-page=452 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓の赤血球抑留並びに動員に関する實驗的研究 第三編 網内系墨汁填塞家兎に於ける諸種物質による骨髓灌流試驗 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤田正明 kn-aut-sei=藤田 kn-aut-mei=正明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=3 article-no= start-page=440 end-page=447 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓の赤血球抑留並びに動員に関する實驗的研究 第二編 植物神経毒による正常家兎骨髓灌流試驗 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤田正明 kn-aut-sei=藤田 kn-aut-mei=正明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=3 article-no= start-page=433 end-page=439 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓の赤血球抑留並びに動員に関する実驗的研究 第一編 鈎虫性催貧血物質並に骨髓物質による正常家兎骨髓灌流試驗 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤田正明 kn-aut-sei=藤田 kn-aut-mei=正明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=11-12 article-no= start-page=689 end-page=696 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cytologial Classification of Leukemias kn-title=白血病の細胞学的分類 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the attempts to classify leukemic cells it is often difficult to identify cells solely with fixed and stained blood smears as in acute leukemia where the percentage of blast cells is high. In such instances, however, it is generally possible to distinguish most cells when vital observations are carried out in conjunction with cytochemical methods, fluorescence micro scopy, as well as electronmicroscopy. The results of these observations have been briefly summarized. The characteristic findings of lymphoblasts, myeloblasts, and monoblasts as revealed by May-Giemsa staining, brilliant cresyl blue supravital staining, phase-contrast microscopy, vital staining and electronmicroscopy. are illustrated in the tables. en-copyright= kn-copyright= en-aut-name=SanadaHiroshi en-aut-sei=Sanada en-aut-mei=Hiroshi kn-aut-name=真田浩 kn-aut-sei=真田 kn-aut-mei=浩 aut-affil-num=1 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=2 ORCID= en-aut-name=KotsukaTakashi en-aut-sei=Kotsuka en-aut-mei=Takashi kn-aut-name=小塚堯 kn-aut-sei=小塚 kn-aut-mei=堯 aut-affil-num=3 ORCID= en-aut-name=OnoyeOsamu en-aut-sei=Onoye en-aut-mei=Osamu kn-aut-name=尾上修 kn-aut-sei=尾上 kn-aut-mei=修 aut-affil-num=4 ORCID= en-aut-name=SakikawaYoshinobu en-aut-sei=Sakikawa en-aut-mei=Yoshinobu kn-aut-name=咲川嘉信 kn-aut-sei=咲川 kn-aut-mei=嘉信 aut-affil-num=5 ORCID= en-aut-name=SaiharaTatsuro en-aut-sei=Saihara en-aut-mei=Tatsuro kn-aut-name=西原達郎 kn-aut-sei=西原 kn-aut-mei=達郎 aut-affil-num=6 ORCID= en-aut-name=HonkeKazunori en-aut-sei=Honke en-aut-mei=Kazunori kn-aut-name=本家和紀 kn-aut-sei=本家 kn-aut-mei=和紀 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=11-12 article-no= start-page=679 end-page=687 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Iron Absorption in Various Blood Diseases Part III. Iron Absorption Rate of Intestinal Mucosa in Patients with Various Blood Diseases kn-title=血液疾患における鉄吸収に関する研究 第3編 血液疾患々者腸粘膜の鉄吸収能 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In normal controls, essential hypochromic anemia and aplastic anemia, biopsies of the duodenal mucosa were performed for an investigation of the amount of stainable iron and iron uptake by means of radioautography. Followings are the conclusions derived from comparison of these two values. 1. The uptake of radioactive iron into the intestinal epithelium is mild in normal controls and remarkable in essential hypochromic anemia, although no differences were noted following iron treatment. Almost no iron was taken up in aplastic anemia. 2. In general, the amount of non-hemine iron in the intestinal mucosa is invertly proportional to iron absorption rate of the intestinal epithelium. This indicates that the intestinal iron absorption is influenced by the amount of intestinal tissue iron, and the intestinal epithelium, bordering the intestinal cannal, plays an important role in the initial stage of the iron absorption. en-copyright= kn-copyright= en-aut-name=TsuchidaJunichiro en-aut-sei=Tsuchida en-aut-mei=Junichiro kn-aut-name=土田潤一郎 kn-aut-sei=土田 kn-aut-mei=潤一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=11-12 article-no= start-page=655 end-page=663 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Iron Absorption in Various Blood Diseases Part 1. Histopathological Observations in Patients with Various Blood Diseases by Intestinal Biopsy kn-title=血液疾患における鉄吸収に関する研究 第1編 血液疾患々者の腸粘膜生検による病理組織学的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In normal controls and patients with various blood diseases, biopsies of the duodenal mucosa were performed for an investigation of histopathological changes and their relation to intestinal iron absorption. Followings are the results. 1. In essential hypochromic anemia, leukemia, and anemia associated with cancer, inflammatory changes were observed, and in a case of acute myelogenous leukemia, infiltration of immature myelogenous cells was observed. 2. Little inflammatory changes were noted in aplastic anemia, suggesting that histological changes in the intestinal mucosa are not related at least to the genesis of this disease. 3. In a case of hookwarm anemia, remarkable inflammatory changes were noted, suggesting the presence of disturbances in the intestinal iron absorption as one of the causes of this anemia. 4. No significant histological changes were observed in myxedema, Mikulicz syndrome, purpura simplex, and pernicious anemia. 5. The above investigations suggest that inflammatory changes of the intestinal mucosa generally have some influences on the iron absorption. en-copyright= kn-copyright= en-aut-name=TsuchidaJunichiro en-aut-sei=Tsuchida en-aut-mei=Junichiro kn-aut-name=土田潤一郎 kn-aut-sei=土田 kn-aut-mei=潤一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2611 end-page=2628 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Hypoplastic Anemia (panmyelopathy); (Mainly depending on our departmental experiences) kn-title=汎骨髓病（再生不良性貧血）について―教室の経験を中心として― en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Japan, hypoplastic anemia has ever been presenting one of the most important problems among today's anemic diseases, it having proved as great frequency as that of pernicious anemia found both in Europe and America; besides, no fit therapeutic method been discovered as yet. Generally speaking, this disease shows a decrease of entire corpuscles, the bleeding tendency becoming prevalent in most cases; yet as to signs in concern to bone marrow, the number of nuclear cell is not fixed, as it has proved 16, 200 at the lowset, while, 263, 000 at the highest. Consequently, it has been classified into 5 types in our department, in view to obstructions of bone marrow. 1. Type of bloodcell-arrest. 2. Type of maturation-arrest. 3. Type of disturbanced regeneration. 4. Mixed type. 5. Panmyelophthisis. When we took record about 23 cases of hypoplastic patients, results were as follows; 1st type 7, 2nd type 2, 3rd type 3, 4th type 8, and 3 cases of 5th type. In all serum iron value proved an increase; in view to intravenous iron tolerance test, the degree of iron disappearance proved a marked delay, while hematopoetic function indicated an extreme decline. In tissue culture of bone marrow invented by our department. it has been recognized that there exists certain factor to inhibit any hyperplasia of parencyma of bone marrow in this anemic serum. As for method in therapy, several have been nominated through in vain, so that more or less effect have been achieved only by our inventions, i.e., imbedding of bone marrow as well as use of substances of polysaccharide extracted from bone marrow. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= en-aut-name=OkanoTakuya en-aut-sei=Okano en-aut-mei=Takuya kn-aut-name=岡野卓也 kn-aut-sei=岡野 kn-aut-mei=卓也 aut-affil-num=2 ORCID= en-aut-name=SaitoTetsuro en-aut-sei=Saito en-aut-mei=Tetsuro kn-aut-name=齊藤哲郎 kn-aut-sei=齊藤 kn-aut-mei=哲郎 aut-affil-num=3 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=4 ORCID= en-aut-name=TanakaMotosuke en-aut-sei=Tanaka en-aut-mei=Motosuke kn-aut-name=田中基介 kn-aut-sei=田中 kn-aut-mei=基介 aut-affil-num=5 ORCID= en-aut-name=YamashitaMiyokichi en-aut-sei=Yamashita en-aut-mei=Miyokichi kn-aut-name=山下三代吉 kn-aut-sei=山下 kn-aut-mei=三代吉 aut-affil-num=6 ORCID= en-aut-name=ShindoTsutomu en-aut-sei=Shindo en-aut-mei=Tsutomu kn-aut-name=進藤勉 kn-aut-sei=進藤 kn-aut-mei=勉 aut-affil-num=7 ORCID= en-aut-name=KuninobuMasuhiro en-aut-sei=Kuninobu en-aut-mei=Masuhiro kn-aut-name=国延益弘 kn-aut-sei=国延 kn-aut-mei=益弘 aut-affil-num=8 ORCID= en-aut-name=TominagaHiroshi en-aut-sei=Tominaga en-aut-mei=Hiroshi kn-aut-name=富永弘 kn-aut-sei=富永 kn-aut-mei=弘 aut-affil-num=9 ORCID= en-aut-name=IshidaToyoshige en-aut-sei=Ishida en-aut-mei=Toyoshige kn-aut-name=石田豊重 kn-aut-sei=石田 kn-aut-mei=豊重 aut-affil-num=10 ORCID= en-aut-name=TakedaToshiteru en-aut-sei=Takeda en-aut-mei=Toshiteru kn-aut-name=武田俊輝 kn-aut-sei=武田 kn-aut-mei=俊輝 aut-affil-num=11 ORCID= en-aut-name=NumamotoTetsuro en-aut-sei=Numamoto en-aut-mei=Tetsuro kn-aut-name=沼本徹郎 kn-aut-sei=沼本 kn-aut-mei=徹郎 aut-affil-num=12 ORCID= en-aut-name=KotakemoriYasuo en-aut-sei=Kotakemori en-aut-mei=Yasuo kn-aut-name=小武守靖 kn-aut-sei=小武 kn-aut-mei=守靖 aut-affil-num=13 ORCID= en-aut-name=NakayamaAkio en-aut-sei=Nakayama en-aut-mei=Akio kn-aut-name=中山章壮 kn-aut-sei=中山 kn-aut-mei=章壮 aut-affil-num=14 ORCID= en-aut-name=HoenSachihiko en-aut-sei=Hoen en-aut-mei=Sachihiko kn-aut-name=方円幸彦 kn-aut-sei=方円 kn-aut-mei=幸彦 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=9 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=10 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=11 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=12 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=13 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=14 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=15 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2601 end-page=2609 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Imbedding of Bone Marrow Part 3: The Histological Influence of the Imbedding of Bone Marrow upon every kind of Internal Organs and the Histological Change of the Embedded Bone Marrow kn-title=骨髓埋沒に関する研究 第3編 骨髓埋沒の各種臓器に及ぼす組織学的影響及び埋沒せる骨髓の組織学的変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) When 0.5 gram per body weight kilogram of bone marrow was embedded to normal rabbits at the inner part of thigh, the histological influence of it upon the bone marrow, the spleen, the liver, the hypophysis and the adrenal glands was observed as follows: The bone marrow……the functional acceleration remarkably appeared on image for a few weeks after imbedding, particularly of homogeneous bone marrow. Other internal organs……no notable change was noticed. Beside, in the case whea the muscles were embedded as a contrasting experiment. no remarkable influence upon the bone marrow could be seen either. 2) A embedded bone marrow, in both cases of homogeneous and of heterogeneous imbedding, was found to get absorbed by degrees into the embedded part, without any hemato poietic function. 3) Between the embedded bone marrow particle and the embedded body, no direct connection through blood vessel was perceived, in both cases of homogeneous and heterogneous imbedding. 4) Judging from above experiences, the following is concluded: The function of embedded bone marrow in promoting the formation of blood does not mean that it produces blood outside of embedded bone marrow when the imbedding is successful, but it means that some peculiar substance to promote the formation of blood, which is contained in bone marrow, is gradually absorbed into the body and directly stimulates the hematopoietic organs in the embedded body. en-copyright= kn-copyright= en-aut-name=MizoteSenichi en-aut-sei=Mizote en-aut-mei=Senichi kn-aut-name=溝手專一 kn-aut-sei=溝手 kn-aut-mei=專一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2569 end-page=2581 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Imbedding of Bone Marrow Part 1: The Influence of the Imbedding of Bone Marrow upon the Peripherial Blood Pictures of Normal Rabbit kn-title=骨髓埋沒に関する研究 第1編 骨髄埋沒の正常家兎血液像に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) When 0.5 gram per body weight kilogram of homogeneous red bone marrow was embedded to normal rabbits at the inner part of thigh, both the hemoglobin and the number of erythrocyte showed a temporary reduction, followed by a remarkable and comparatively long-lasting increase of them. In this connection, the increase of reticulocyte was, prior to that of erythrocyte, also notably found. 2) The same response was shown also in the case of embedding 0.3 gram per body weight kilogram, but in this case the response was rather slight. 3) In the case of embedding 1.0 gram per body weight kilogram, only the anemia was resulted, no increase of erythrocyte being caused. 4) The same response as in the first imbedding was found in another experiment under the same condition (0.5 gram per body weight kilogrem), but this time the reduction of erythrocyte on early stage was slight and no particular disorder was noted. 5) When 0.5 gram per body weight kilogram of heterogeneous (- of a young dog -) red bone marrow was embedded to normal rabbits, the response was almost the same with the case of embedding homogeneous one, although the respose in slighter degree. 6) In the cases of embedding 0.5 gram per body weight kilogram both of homogeneous and heterogeneous muscles instead of red bone marrow, the blood-picture of embedded body did not show any notable change. 7) Judging from above experiences, the fact has become clear that the imbedding of bone marrow has its peculiar function inpromoting the production of blood, and that the fittest puantity of it is 0.5 gram per body weight kilogram. en-copyright= kn-copyright= en-aut-name=MizoteSenichi en-aut-sei=Mizote en-aut-mei=Senichi kn-aut-name=溝手專一 kn-aut-sei=溝手 kn-aut-mei=專一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2545 end-page=2567 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Behavior of the Bone Marrow in Acute Hemorrhage Part 3: The Effect of Bleeding on the State of Blood Circulation in the Bone Marrow and on the General Circulation Time kn-title=急性出血に於ける骨髓の態度に関する研究 第三編 瀉血の骨髓内血液循環状態及び全身血液循環時間に及ぼす影響に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is readily assumed that acute bleeding would cause changes in the speed of general circulation and in the circulation of bone marrow blood, and that such a change of bone marrow blood circulation would largely effect the mobilization of bone marrow depot blood cells. INOUE and Prof. HIRAKI have pointed out that the acceleration or inhibition of bone marrow circulation accompanied by the contraction or dilation on the nutricia vessels constitutes an important factor in accelerating or inhibiting the mobilization of bone marrow blood cells. From this account, the results obtained through the experiments described in Part 1 have been reviewed, and the effect of bleeding upon the blood circulation in the bone marrow and the general circulation time has been re-examined through the thiasin method and the STEWART's method. The results are as follows: 1) The blood flow curve in the bone marrow taken by means of the thiasin method reached its peak within an hour after the bleeding. The curve taken at the 30 miuutes period before and after reaching its peak showed a shift to the left, indicating an acceleration of the blood flow. 2) The circulation time in the bone marrow was shortened, with its peak an hour after the bleeding, the values at 30 minutes before and after the peak showing various degrees of shortened time. 3) The pulmonary and systemic circulation time was shortened with its peak an hour after the bleeding, the values at 30 minutes before and after the peak showing various degrees of shortened time. 4) These observations suggest the events which take place in the marrow in the course of one to two hours after hemorrhage. The increase of blood cells in V. nutricia femoris was caused by mobilization of depot blood cells in the sinusoid. This mobilization was brought about by the shortening of the intramedullary circulation time associated with that of the general circulation time. Dilation and contraction of nutricia vessels following bleeding is only of secondary significance. en-copyright= kn-copyright= en-aut-name=TachibanaTateki en-aut-sei=Tachibana en-aut-mei=Tateki kn-aut-name=橘建樹 kn-aut-sei=橘 kn-aut-mei=建樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2525 end-page=2544 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Behavior of the Bone Marrow in Acute Hemorrhage Part 2: The Effect of Neural Transection on the Bone Marrow Blood Cell Mobilization after Bleeding kn-title=急性出血に於ける骨髓の態度に関する研究 第二編 神経切断が瀉血による骨髄血球動員に及ぼす影響に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=Following the experiments stated in Part 1, in order to examine the blood cell mobilization function of the bone marrow from the viewpoints of central nervous system control and peripheral nervous system control, the blood picture of the V. nutricia was observed after transecting the spinal cord at a higher level, as did KOMIYA, and also after extirpating the abdominal sympathetic nerve, as did MORIKAWA. The results are as follows: 1) The marked mobilization of the bone marrow depot blood cells, which is seen 1 to 2 hours after the bleeding, was not hindered by the transection of the higher-level spinal cord. Therefore, the mobilization is little effected by the central blood cell control nerves. 2) Mobilization of the bone marrow depot blood cells is not much effected by the extirpation of the abdominal sympathetic trunk. Therefore, its control by the peripheral nerves is negligible. 3) The dilation or contraction of the nutricia vessels do not have a primary significance in the mobilization of the bone marrow blood cells after bleeding. en-copyright= kn-copyright= en-aut-name=TachibanaTateki en-aut-sei=Tachibana en-aut-mei=Tateki kn-aut-name=橘建樹 kn-aut-sei=橘 kn-aut-mei=建樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2505 end-page=2523 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Behavior of the Bone Marrow in Acute Hemorrhage Part 1: Bone Marrow as the Blood Depot Organ and the Mobilization of Blood Cells from the Bone Marrow caused by Blood-letting kn-title=急性出血に於ける骨髓の態度に関する研究 第一編 血球貯溜器官としての骨髓並に瀉血による骨髓の血球動員に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to determine whether or not depot blood cells in the bone marrow are mobilized into the circulating blood at acute hemorrhage, as does the depot blood in other blood depot organs. Acute bleeding was applied to a rabbit and the change in hemogram of V. untricia femoris was observed. Secondly, an acute bleeding was applied to a rabbit of which the reticuloendothelial system was blocked with India ink, to observe how the blood finding of V. nutricia femoris will be effected and to compare this result with that of the first experiment. The findings are as follows: 1) When the rabbit was bled to the extent of 15 to 20cc per Kgm., the rate of decrease of red blood cells in the V. nutricia femoris was much less than that in the corresponding A. femoralis. Not only the number did not decrease, but it increased, reaching the peak 1 to 2 hours after the bleeding. Following the increase, however, the number gradually decreases until it becomes almost the same as the number of blood cells in the A. femoralis. The increase of white blood cells is much more rapid and distinct than the rate of increase of the corresponding A. femoralis blood; it marks the same peak as the red blood cell system 1 to 1 and a half hour after the bleeding. Such an increase of blood cells in V. nutricia femoris is due to the mobilization of marrow depot blood cells. From this, the bone marrow may be called one of the blood cell depot organs, having much significance in supplying blood cells to the blood circulation in case of acute hemorrhage. 2) On the other hand, no such blood cell mobolization can be seen when the rabbit with its reticuloendothelial system blocked with India ink is bled. Therefore, it is concluded that the sound functioning of the reticuloendothelial system is essential for the mobilization of bone marrow blood cells. 3) A marked contraction of the nutricia vessels was observed immediately after the bleeding, for both the non-treated rabbit and the rabbit with its reticuloendothelial system blocked with India ink. Though the contraction began to recover 30 to 60 minutes after the bleeding, the blood vessel did not recover its original diameter of before the bleeding, at least until the termination of the experiment. en-copyright= kn-copyright= en-aut-name=TachibanaTateki en-aut-sei=Tachibana en-aut-mei=Tateki kn-aut-name=橘建樹 kn-aut-sei=橘 kn-aut-mei=建樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=11 article-no= start-page=2289 end-page=2307 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=STATISTICAL OBSERVATION ON 28 CASES OF HYPOP-LASTIC ANEMIA. (PANMYELOPATHIA) kn-title=汎骨髓病症（再生不良性貧血）28例の統計的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We have taken observations on 28 cases of Panmyelopathia, all of which belonged to inpatients of our dept., statistically and clinically; results were as follows:- There were found no definite co-relations either iu age, sex. or by occupation; except 1 case of chronic X-Ray injury; for conscious symptoms, facial paleness was found almost inevitably, while fever, general languor, and palpitation were discovered to succeed it; as for the bleeding, in main it was wont to appear in the form of gingival bleeding, epistaxis, or ecchymosis; for symptoms that were discovered by others, red-cell sedimentation rate was found to be stimulated, in total cases, and such as lengthened bleeding time, anemic cardiac murmurs, together with changes in the eye ground, was recognizable in most cases. Among the blood figure. number of red cells was seen to be about a million or so in majority of cases; while, figures below 1 million was considered to point at serious prognosis. As to hemoglobin content, in most cases, it occupied 20% or so; in respect to hemoglobin index, most of them indicated a hyperchrom, over the entire process, or in partial process. In most cases, the numher of leucocytes proved to be short of 4000, which was also supposed to keep much co-relation with the prognosis. In view to differentiation of lencocytes, a decrease of grauulocytes, an increase of lymphocytes appeared, and in general, in deceased cases, lymphocytosis was clearly observed. Number of blood platelet were apt to decrease to a certain extent. Number of reticulocytes was seen to be small in majority of cases, but it would seem unreasonable to refer to it for the state of prognosis. Heinz' body proved, in serious cases, a value pretty nigh to 1, 000‰, showing a great difference with that, belonging to another sort of anemic diseases, as well as people in healthy condition. No special phase was foundin the myelogramm; in respective disease, various apperances of hematopoetic functions observed. The disease could generally be divided into following 5 types. I. Type of bloodcell-arrest. II. Type of maturation-arrest III. Type of disturbanced regeneration. IV. Mixed type. V. Panmyelophthisis. By dint of Tissue Culture of bone marrow. it has been supposed that there existed certain factor that inhibited growth of parenchyma of bone marrow directly; moreover, the functions of bone marrow have suffered a marked hindrance; Having examined respiration and glycolysis in bone marrow, it was discovered that with type of blodcell-arrest, it has proved normal; with other typs, proved considerablly low value. Its sideroblastogram proved slightly to shift to the right. Generally in most cases, gastric juice showed certain hypoacidity. Among the circulatory system, no unique quality discovered, while the rise in serum iron value was seen, owing to extreme decrease of hematopoetic function. Amongst urine and cerebrospinal fluid, some anemia-causing substance has been detected. As for sugar metabolism, rate for normal and abnormal stood almost the same; while as for the basal metabolism, there was discovered some abnormality. The function test of autonomic nervous system, also showed much abnormality. As to histological view, a high degree atrophy was discovered in hematopoetic tissue, with a marked bleeding tendency. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= en-aut-name=NumamotoTetsuro en-aut-sei=Numamoto en-aut-mei=Tetsuro kn-aut-name=沼本徹郎 kn-aut-sei=沼本 kn-aut-mei=徹郎 aut-affil-num=2 ORCID= en-aut-name=TamuraHajime en-aut-sei=Tamura en-aut-mei=Hajime kn-aut-name=田村甫 kn-aut-sei=田村 kn-aut-mei=甫 aut-affil-num=3 ORCID= en-aut-name=OkanoTakuya en-aut-sei=Okano en-aut-mei=Takuya kn-aut-name=岡野卓也 kn-aut-sei=岡野 kn-aut-mei=卓也 aut-affil-num=4 ORCID= en-aut-name=KitayamaMinoru en-aut-sei=Kitayama en-aut-mei=Minoru kn-aut-name=北山稔 kn-aut-sei=北山 kn-aut-mei=稔 aut-affil-num=5 ORCID= en-aut-name=TakedaKatsumi en-aut-sei=Takeda en-aut-mei=Katsumi kn-aut-name=武田勝美 kn-aut-sei=武田 kn-aut-mei=勝美 aut-affil-num=6 ORCID= en-aut-name=TsushimaMakoto en-aut-sei=Tsushima en-aut-mei=Makoto kn-aut-name=津島允 kn-aut-sei=津島 kn-aut-mei=允 aut-affil-num=7 ORCID= en-aut-name=NakatsukaGinta en-aut-sei=Nakatsuka en-aut-mei=Ginta kn-aut-name=中塚銀太 kn-aut-sei=中塚 kn-aut-mei=銀太 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=773 end-page=789 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=各種動物長管骨々髓の血管構造 第3編 細部血管構造に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片山茂樹 kn-aut-sei=片山 kn-aut-mei=茂樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=751 end-page=772 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=各種動物長管骨々髓の血管構造 第2編 鳥類，両棲類，爬虫類の長管骨々髄主幹血管に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片山茂樹 kn-aut-sei=片山 kn-aut-mei=茂樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=727 end-page=750 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=各種動物長管骨々髓の血管構造 第1編 家兎を主とせる哺乳類の長管骨々髄主幹血管に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片山茂樹 kn-aut-sei=片山 kn-aut-mei=茂樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=719 end-page=725 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓に関する実験的研究 第三編 P(32)による骨髄内循環状態の検索及び 主要全身骨々髄の燐代謝に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=副島哲郎 kn-aut-sei=副島 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=705 end-page=718 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓に関する実験的研究 第二編 自律神経毒による白血球の骨髄内抑留並に動員に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=副島哲郎 kn-aut-sei=副島 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=691 end-page=704 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓に関する実験的研究 第一編 鉤虫性催貧血物質及骨髄物質による白血球の骨髄内抑留竝に動員に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=副島哲郎 kn-aut-sei=副島 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=675 end-page=689 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓の細胞学的研究 第三編 葉酸並にビタミンB(12)の骨髄直接刺戟性に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=上村家門 kn-aut-sei=上村 kn-aut-mei=家門 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=661 end-page=673 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓の細胞学的研究 第二編 諸種貧血家兎の骨髄像並に核酸，多糖類染色に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=上村家門 kn-aut-sei=上村 kn-aut-mei=家門 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=643 end-page=659 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓の細胞学的研究 第一編 諸種血液疾患々者の骨髄像並に核酸，多糖類染色に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=上村家門 kn-aut-sei=上村 kn-aut-mei=家門 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=633 end-page=642 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=レ線間脳照射の骨髓造血機転に及ぼす影響 第四編 鈎虫症骨髄スペレに及ぼすレ線間脳照射の影響 附）再生不良性貧血患者に対する臨牀実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=塩見哲夫 kn-aut-sei=塩見 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=627 end-page=632 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=レ線間脳照射の骨髓造血機転に及ぼす影響 第三編 骨髄造血機転に対する網内系の関與について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=塩見哲夫 kn-aut-sei=塩見 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=615 end-page=625 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=レ線間脳照射の骨髓造血機転に及ぼす影響 第二編 レ線間脳抑制量照射による骨髄の血球抑留について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=塩見哲夫 kn-aut-sei=塩見 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=603 end-page=613 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=レ線間脳照射の骨髓造血機転に及ぼす影響 第一編 レ線間脳弱照射による骨髄の血球動員について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=塩見哲夫 kn-aut-sei=塩見 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=585 end-page=602 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓血管の発生学的研究 第三編 下腿骨骨髄血管 家兎胎生期並びに発育期 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大枝亘 kn-aut-sei=大枝 kn-aut-mei=亘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=563 end-page=583 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓血管の発生学的研究 第二編 大腿骨骨髄血管（其の二）家兎新生児並びに幼若家兎 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大枝亘 kn-aut-sei=大枝 kn-aut-mei=亘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=545 end-page=562 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨髓血管の発生学的研究 第一編 大腿骨骨髄血管（其の一）家兎胎生期 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大枝亘 kn-aut-sei=大枝 kn-aut-mei=亘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=3 article-no= start-page=411 end-page=416 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=進行性顏面半側萎縮症の2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中基介 kn-aut-sei=田中 kn-aut-mei=基介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=3 article-no= start-page=395 end-page=410 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Adrenalin-Eosinopenieに関する実験的研究 試験管内血液への添加実験並に骨髄好酸球像の組織学的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=須賀宏文 kn-aut-sei=須賀 kn-aut-mei=宏文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=3 article-no= start-page=383 end-page=390 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=鉤虫症鉄代謝に関する研究 第3編 鉤虫症血清注射の貯藏鉄に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=米谷公夫 kn-aut-sei=米谷 kn-aut-mei=公夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=3 article-no= start-page=375 end-page=381 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=鉤虫症鉄代謝に関する研究 第2編 鉤虫症血清注射の影響並びに網内系の意義 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=米谷公夫 kn-aut-sei=米谷 kn-aut-mei=公夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=3 article-no= start-page=365 end-page=373 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=鉤虫症鉄代謝に関する研究 第1編 鉤虫症血清鉄量に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=米谷公夫 kn-aut-sei=米谷 kn-aut-mei=公夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=3 article-no= start-page=361 end-page=364 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ホルネル氏症候群を呈せる縱隔竇腫瘍の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡野卓也 kn-aut-sei=岡野 kn-aut-mei=卓也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=1 article-no= start-page=13 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Typhobacilloseの1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤森明良 kn-aut-sei=藤森 kn-aut-mei=明良 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=橘建樹 kn-aut-sei=橘 kn-aut-mei=建樹 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=975 end-page=984 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EXPERIMENTAL STUDIES ON JAPANESE B ENCEPHALITIS WITH THE RADIOACTIVE P(32) 3. INFLUENCES OF RADIOACTIVE P(32) UPON JAPANESE B ENCEPHALITIS IN MICE kn-title=P(32)による実験的日本脳炎に関する研究 第三篇 日本脳炎罹患マウスに及ぼす放射性同位元素P(32)の影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influences of P(32) upon the mice infected with Japanese B Encephalitis were investigated. On the course of this investigation, the effects of P(32) upon the formation of nuclear inclusion-body was also histologically determined on the brains of infected mice. With the mice which had been intracerebrally injected with the virus at the concentration of about LD(50) the delay of infection and prolonged survival time were usually observed when therapeutic doses of P(32) were intraperitoneally given. This was also the case when the virus had been inoculated intraperitoneally or intravenously. In all these cases, the formation of nuclear inclusion-body was always more distinct than that of the control references. en-copyright= kn-copyright= en-aut-name=OsadaTakahisa en-aut-sei=Osada en-aut-mei=Takahisa kn-aut-name=長田高寿 kn-aut-sei=長田 kn-aut-mei=高寿 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=5 article-no= start-page=961 end-page=974 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EXPERIMENTAL STUDIES ON JAPANESE B ENCEPHALITIS WITH THE RADIOACTIVE P(32) 2. INVESTIGATION OF NUCLEIC ACID METABOLISM BY SCHMIDT & THANHAUSER'S MFTHOD IN THE ORGANS, BRAIN AND LIVER, OF MICE INFECTED WITH JAPANESE B ENCEPHALITIS VIRUS kn-title=P(32)による実験的日本脳炎に関する研究 第二篇 脳内病毒接種マウス脳及び肝に於ける核酸代謝のSchmidt & Thanhauser法による研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the previous paper by the same author the nucleic acid metabolism in some organs which was infected by Japanese B Encephalitis was studied by Schneider's method. Some detailed study by Schmidt & Thanhauser's method on this problem was further undertook and is going to be reported here. P(32) was used as the tracer throughout this investigation and was injected intraperitoneally into the mice at the acme stage of infection. After the time intervals of 6 and 24 hours were collected certain quantities of brain, which were then fractionated by Schmidt & Thanhauser's method into DNH- and RNA- fractions These nucleic acid fractions were investigated on their P(32) contents. By comparing the results with those obtained from the control references made by treating the healthy mice with P(32) in the same way, an increase in P(32)-activity was recognized at the DNA-fraction of the brain, this indicating the fact that, when mouse is infected with the virus, the DNA-fraction of the brain suffers a marked change. Similar investigation was also carried out at the incubation period. In this case, however, an increase in the P(32)-activity was observed at the DNA and PNA-fraction of the liver collected from the mice infected with the virus. It is fully interesting that this increase in P(32)-activity shows intimate accordance with the visceral phase of the disease. en-copyright= kn-copyright= en-aut-name=OsadaTakahisa en-aut-sei=Osada en-aut-mei=Takahisa kn-aut-name=長田高寿 kn-aut-sei=長田 kn-aut-mei=高寿 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3-4 article-no= start-page=815 end-page=828 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Polysaccharides Extracted from Bone Marrow Part III: Influence of Polysaccharides Extracted from Bone Marrow, Function on Liver kn-title=骨髓抽出多糖類物質に関する研究 第3編 骨髄抽出多糖類物質の肝機能に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) This polysaccharides extracted from the bone marrow as stated in part I can induce the increase of erythrocytes which continue for a few hours after its injection, in the rabbit which has undergone a disturbance in the liver owing to C Cl(4), and which has been extirpated its spleen before 48 hours and 30 days. 2) If this substance be injected in a rabbit who suffers from reticulo-endotherial system due to indian ink, these would be detected no trace of increase of erythrocytes. Further, by circulation test of bone marrow with thiasin, due to our departmental invention, found that this injection could improve the blood circlatin within bone marrow. 3) With rabbits suffering from venesation anemia, phenylhydrazin anemia and collargol anemia, the injection of this substance has certain effect in urging recovery from anemia. en-copyright= kn-copyright= en-aut-name=TakagiRyoji en-aut-sei=Takagi en-aut-mei=Ryoji kn-aut-name=高木良二 kn-aut-sei=高木 kn-aut-mei=良二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3-4 article-no= start-page=795 end-page=814 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Polysaccharides Extracted from Bone Marrow Part II: Influence of Polysaccharides Extracted from Bone Marrow, on Hematopoietic Function kn-title=骨髓抽出多糖類物質に関する研究 第2編 骨髄抽出多糖類物質の造血機能に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) This polysaccharides extracted from the bone marrow as stated in part I can induce the increase of erythrocytes which continue for a few hours after its injection, in the rabbit which has undergone a disturbance in the liver owing to C Cl(4), and which has been extirpated its spleen before 48 hours and 30 days. 2) If this substance be injected in a rabbit who suffers from reticulo-endotherial system due to indian ink, these would be detected no trace of increase of erythrocytes. Further, by circulation test of bone marrow with thiasin, due to our departmental invention, found that this injection could improve the blood circlatin within bone marrow. 3) With rabbits suffering from venesation anemia, phenylhydrazin anemia and collargol anemia, the injection of this substance has certain effect in urging recovery from anemia. en-copyright= kn-copyright= en-aut-name=TakagiRyoji en-aut-sei=Takagi en-aut-mei=Ryoji kn-aut-name=高木良二 kn-aut-sei=高木 kn-aut-mei=良二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3-4 article-no= start-page=777 end-page=794 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Polysaccharides Extracted from Bone Marrow Part I: Methode to Extract Polysaccharides of Bone Marrow; its Property and Paper Chromatography kn-title=骨髓抽出多糖類物質に関する研究 第1編 骨髄多糖類物質の抽出分離法及びその性状とペーパー・クロマトグラフイー en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) I have succeeded in the extraction of bone marrow polysaccharides out of red bone marrow of a calf due to method in which first of all I make them issue out into the water after it have been heated into the distillated water, remove the protein content owing to CuSo(4) and NaoH; then, removing the salt by ion-exchange resin, cause it to precipitate due to alcohol and ether. 2) This substance is exhibited as white powder with non-crystal nature, which sustains a slight degree of wet-absorbing property, and able to dissolve easy in water, but is indisoluble toward ether, alcohol and aceton. Also, it invariably has proved to be (+) in Molisch reaction, but to be (-) in any these reactionse of Biurt, Sulfosalicyl acid, Xanthoprotein and Ninhydrin. Furthermore, by hydrolysis, it has reduced to Fehling solution and after analysis of element I cannot detect any nitrogen. 3) In case a proper amount of this aubstance (per Kg 1mg) be injected into ear veins of a normal rabbit, an increase of erythrocytes has been detected for a few hours after the injection. This function has proved rather tough toward alkali or heat, but is lost by being heated due to acid. 4) I could detect Galactose, Rhamnose, Glucuronic acid and Galacturonic acid for its constituent sugars, owing to paper chromatography. en-copyright= kn-copyright= en-aut-name=TakagiRyoji en-aut-sei=Takagi en-aut-mei=Ryoji kn-aut-name=高木良二 kn-aut-sei=高木 kn-aut-mei=良二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3-4 article-no= start-page=719 end-page=729 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the effect of the nutrient vessels of the bone-marrow upon the bone-marrow circulation Part 3: The change in point of the time of the bone-marrow circulation caused by ligating the principal nutrient vessel of a rabbit femur kn-title=骨髓諸種栄養血管系の骨髓循環に及ぼす影響に関する研究 第三編 家兎大腿骨主要栄養血管結紮による骨髄血行の時間的変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In investigating how long it takes the bone-marrow circulation to recover after the ligating of the principal nutrient vessel of a rabbit femur with Radioisotope P(32) as a tracer, the following results were obtained. 1) When the principal nutrient artery of a fully grown rabbit is ligated, the bone-marrow circulation is about 20% of control within the lapse of one day, but the recovery by the collateral circulation is by degrees seen and the complete recovery is realized in one month. But some recovers rather more quickly, the other slowly, by each individual difference. 2) When the principal nutrient artery of a young rabbit femur is ligated, the recovery of the bone-marrow circulation is rather slow than that in the case of a fully grown rabbit. That is to say, the connection of the principal nutrient artery with the other nutrient artery in a young rabbit is worse than that in the case of a fully grown rabbit. 3) When the principal nutrient vessel of a fully grown rabbit femur is ligated, the bone-marrow stagnation recovers in the early stage. This is caused by the same reason as that expressed in the 3) item of the part 2. en-copyright= kn-copyright= en-aut-name=TakedaToshiteru en-aut-sei=Takeda en-aut-mei=Toshiteru kn-aut-name=武田俊輝 kn-aut-sei=武田 kn-aut-mei=俊輝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3-4 article-no= start-page=709 end-page=718 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the effect of the nutrient vessels of the bone-marrow upon the bone-marrow circulation Part 2: The blood-supplying percentage of the nutrient vessels of a rabbit femur upon the bone-marrow circulation kn-title=骨髓諸種栄養血管系の骨髓循環に及ぼす影響に関する研究 第二編 家兎大腿骨々髄諸種栄養血管系の骨髄血行支配率 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After investigating how the nutrient vessels distributed in a rabbit femur control the bone-marrow circulation with Radioisotope P(32) as a tracer, the following results were obtained. 1) The difference of the blood quantity supplied into both femur marrows from the nutrient arteries is within 4%. 2) Observing the controlling state of the bone-marrow circulation of the nutrient arteries, the controlling power of the principal nutrient artery is 79%, the greatest percentage of all. Next, that of the periosteal artery is 14%, and that of the vessels in the metaphysis and diaphysis is 7%, being of the least significance. 3) When the principal nutrient vein is ligated, the bone-marrow stagnation is very slight. This is because the veins except the principal nutrient one are better developed than the arteries except the principal nutrient one, and the bone-marrow, being contained in bone, is difficult to increase in the volume. en-copyright= kn-copyright= en-aut-name=TakedaToshiteru en-aut-sei=Takeda en-aut-mei=Toshiteru kn-aut-name=武田俊輝 kn-aut-sei=武田 kn-aut-mei=俊輝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=221 end-page=230 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Organ Extracts as well as Serum of Blood Disease Patient on the Nucleic Acid Metabolism of a Rabbit 4th Report: Studies on The Nucleic Acid Metabolism due to Radioactive Isotope P(32) kn-title=臓器エキス並に血液疾患々者血清の家兎臓器核酸代謝に及ぼす影響 第4編 放射性同位元素P(32)による核酸代謝の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The once quantitatively estimated metabolism of nucleic acid in various organs has been put under examination, in view to its turnover rate, in terms of P(32), in its progressive form. 1) The ups and downs in nucleic acid amount does not always go parallel with the turnover rate. Therefore, when one considers the co relation between physiological or pathological funtion and nucleic acid, it is necessary to draw a strict distinctive line to tell whether it has certain concern with its quantitative transition, or with its turnover rate. 2) In case any serum has been injected except healthy person's the bone marrow nucleic acid, esp., the DNA wont to show a candid increase in its turnover rate; simultaneouly, if we consider it side by side with the extract administered case, we connot but imagine that the co-relation of bone-marrow nucleic acid metabolism and the number of peripheral blood carpusele should prove comparatively indirect one. 3) The liver DNA, though scarce compared to others, indicates a considerable rate in its turnover phase. From this, it may roughly be concluded that even if it be static nuclear DNA, maintains its metabolism which betrays the mistake in the theory that has termed it as stabilized and has no turnover faculty. 4) In the injection of serum, the spleen nucleic acid, above all, the turnover rate of DNA proves greater than bone-marrow; moreover, at this time, if one realizes the powerful growth of lymph follicles, it might be deemed suggestive of certain relation that exists between DNA turnover and splitting of cells. en-copyright= kn-copyright= en-aut-name=NambaTatsuji en-aut-sei=Namba en-aut-mei=Tatsuji kn-aut-name=難波達治 kn-aut-sei=難波 kn-aut-mei=達治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=213 end-page=219 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Organ Extracts as well as Serum of Blood Disease Patient on the Nucleic Acid Metabolism of a Rabbit 3rd Report: Cytochemical Studies kn-title=臓器エキス並に血液疾患々者血清の家兎臓器核酸代謝に及ぼす影響 第3編 細胞化学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) The nucleic acid amount that has been estimated in view to chemical determination in the previous 2 reports, have here been laid under the observation cytochemically, according to Feulgen reaction (DNA) and thionine staining (RNA). 2) Having maintained some investigations on Ketoenol substances (KES), i.e., oligonucleotide of DNA, the bone marrow KES has proved to rise in amount on occasions when slpeen extracts, essential hypochromic anemia serum, serum of Banti's syndrome have been applied. The liver KES, comparing in general to the controls, increases; above all, to a marked degree, in case of hypoplastic anemia or hookworm anemia serum is concerned. The spleen KES shows a rise in case extracts of liver and spleen, together with serum of Banti's syndrome and healthy men have been injected; also shows a great increase when serum of essential hypochromic anemia, esp., the bone-marrow extract has been employed. The kidndy KES quite increases when the bone-marrow extract, spleen extract as well as the serum of Banti's syndrome or healthy men have been applied. en-copyright= kn-copyright= en-aut-name=NambaTatsuji en-aut-sei=Namba en-aut-mei=Tatsuji kn-aut-name=難波達治 kn-aut-sei=難波 kn-aut-mei=達治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=201 end-page=212 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Organ Extracts as well as Serum of Blood Disease Patient on the Nucleic Acid Metabolism of a Rabbit 2nd Report: Influences of Serum of Patients of Blood Disease on the Nucleic Acid Quantity of Rabbit's Organs kn-title=臓器エキス並に血液疾患々者血清の家兎臓器核酸代謝に及ぼす影響 第2編 血液疾患々者血清の家兎臟器核酸量に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By intravenous injection of serum of patients of blood disorder as well as control serum of healthy men, observed the nucleic acid appearing in its bone-marrow, liver, spleen, and kidney, which proved as: 1) In case healthy men's serum has been injected, bone-marrow nucleic acid and DNA in, liver, spleen, and kidney indicate a decrease; while RNA both in spleen and kidney increases slightly; and that of liver does so pretty much. If those results obtained will be put under comparison with those obtained under the use of healthy men's serum: 2) Under the administration of serum of hypoplastic anemia, bone-marrow nucleic acid increases in a marked degree, liver as well as kidney DNA do so in a moderate degree; RNA of liver and kidney decrease rather. As to spleen nucleic acid, no marked change occurs. 3) If the serum of leukemia is injected, a slight increase takes place to liver and spleen DNA, while liver and kidney RNA show an abatement quite: but as to the rest, no great changes appear. 4) When serum of Banti's syndrome has been injected, the increase of both the bone-marrow nucleic acidi prove most caundid: though the spleen DNA increases, liver nucleic acid as well as RNA of spleen and kidney show a slight decrease respectively. 5) On occasion serum of hookworm anemia has been injected, spleen nucleic acid proves a marked increase; bone-marrow DNA increases greatly, but RNA in liver and kidney decreases. 6) When serum of essential hypochromic anemia is injected, a remarkable increase in the bone-marrow nucleic acid happens; but, as to the rest, small change occurs, only a slight increase of liver and spleen DNA, along with a decrease of liver RNA. en-copyright= kn-copyright= en-aut-name=NambaTatsuji en-aut-sei=Namba en-aut-mei=Tatsuji kn-aut-name=難波達治 kn-aut-sei=難波 kn-aut-mei=達治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=189 end-page=199 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Organ Extracts as well as Serum of Blood Disease Patient on the Nucleic Acid Metabolism of a Rabbit 1st Report: Influences of Organ Extracts on the Amount of Rabbits' Organ Nucleic Acid kn-title=臓器エキス並に血液疾患々者血清の家兎臓器核酸代謝に及ぼす影響 第1編 臟器エキスの家兎臟器核酸量に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After having injected intraperitoneally, such substances as extracts of the bone-marrow, liver, spleen as well as skeletal muscle, once a day, and in determining quantitatively, the nucleic acid contained in rabbit's bone marrow, liver, spleen, and kidney, in pursuit of the lapse of time, from 6 hours to 9 days, obtained results as follows: 1) The amount of organ nucleic acid (mg/100g) for a healthy rabbit proved: bonemarrow: DNA 728, RNA 45.7. liver: DNA 36.6, RNA 88.9. spleen: DNA 100.2, RNA 65.3. kidney. DNA 38.4, RNA 56.3. 2) By injection of bone marrow extract, the bone marrow DNA, after having decreased for a time, increased; so did RNA too. The liver DNA showed an increase, while, RNA decreased. The spleen DNA increased, after having decreased; RNA, ambiguous. Kidney nucleic acid proved variable, but in general showed increase in DNA. 3) By injection of liver extract, the bone-marrow nucleic acid proves increase in both the constituents, through a temporal decrease; while, RNA increases, The nucleic acid amount in the liver is indefinite but in general, proves certain decrease; kidney nucleic acid, whereas it is lacking in general in DNA, having once abated, newly increases. 4) In injection of liver extract, in general, bone marrow-DNA proves increase, while RNA increases after a decrease. In the liver, DNA shows an increase after a little time of decrease, while, RNA seen to have kept increasing in all. In the spleen, both DNA and RNA have a tencency to increase after having shown a slight decrease. As to kidney, there was observed a marked decrcase of RNA. 5) In case skeletal muscle extract has been injected, bone marrow RNA indicates more remarkable increase than with other extracts; in the liver both nucleic acids, esp. RNA increases; as to spleen, there RNA has generally been fixed; but DNA proves decrease in proprotion to the frequency of injection; while, the kidney nucleic acid show little change. en-copyright= kn-copyright= en-aut-name=NambaTatsuji en-aut-sei=Namba en-aut-mei=Tatsuji kn-aut-name=難波達治 kn-aut-sei=難波 kn-aut-mei=達治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=165 end-page=188 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and Clinical Study on the Bone Marrow Transplantation Part 3: Clinical study on the bone marrow transplantation and treatment due to intravenous injection of polysaccharide extracted from bone marrow kn-title=骨髓埋沒に関する実験的並に臨床的研究 第3編 再生不良性貧血患者に於ける骨髄埋没並に骨髄抽出多糖類物質療法の臨床 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Obtained results as follows, by performing bone marrow transplantation and intravenous injection of polysaccharide extracted from bone marrow, for 10 cases of patients of hypoplastic anemia. 1) Performing the treatment due to bone marrow transplantation for 3 cases, obtained very good results. Above all, it proved so poignantly its effect in a patient suffering seriously; at some occasions, his anemia indicated a recovery nearly like a person of health; could survive for a pretty long period. 2) Having intravenously injected polysaccharide extracted from bone marrow for 7 cases, recognized an inerease of blood cells in 5 cases, while in the remaining 2 cases it proved in vain. Among successful cases, 3 showed a marked increase in blood cells and recovered from anemia, but in the other two blood cells have increased for a while after several times of injection. Cases which proved effectless were all been serious ones, with whom the image of bone marrow have proved panmyelophthisis. These effects shown in the blood cells increase due to bone marrow transplantation would justly be interpreted as Miyakawa had told, that it has worked autohormonly, since there were seen results of stimulated function of hematopoetie organs, which has undergone some stimulus from effective substances contained in transplanted bone marrow; moreover, polysaccharide extraded from bone rmarrow are supposed, not only have power to dilate marrow vessels, and send out of blood cells in the Lone marrow, but also it has been vindicated to be able to increase of blood cells by stimulating the parenchyma of bone marrow. as was seen under our experiment on bone marrow tissue culture; and would be recommended as a method in clinic for patients of hypoplastic anemia, for which men believed hitherto to have no fit remedy. en-copyright= kn-copyright= en-aut-name=OkanoTakuya en-aut-sei=Okano en-aut-mei=Takuya kn-aut-name=岡野卓也 kn-aut-sei=岡野 kn-aut-mei=卓也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=137 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and Clinical Study on the Bone Marrow Transplantation Part 2: The Co-relation between the recovery of experimental anemia due to bone marrow transplantation, iron metabolism and function of reticuloendothelial system kn-title=骨髓埋沒に関する実験的並に臨床的研究 第2編 骨髓埋沒による実験的貧血の恢復と鉄代謝及び網内系機能との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By inducing anemia in animals by such means as; blood-letting, phenylhydrazin injection, benzol injection, X-ray irradiation, kollargol injection, or anchylostoma; then, by performing Prokg. 0.5g bone marrow transplantation for those animals, obtatined results as follows: 1) The bone marrow transplantation has power to stimulate recovery from anemia; on that time, serum iron quantity proves a decrease, while function of reticuloendothelial system proves either excessive, or in case showing low, has room to be stirred up to recovery. 2) In general, the recovery of serum iron quantity to normal value is apt to be delayed compared to that of anemia 3) In kollargol anemic dog, the quantity of serum iron shows a marked increase. 4) The function of reticuloendothelial system with anchylostoma anemia shows a remarkable excitement, anemia cannot be recovered by sole bone marrow transplantation: it has not been recovered until helmintics has been employed; In case bone marrow transplantation and helmintic use have been performed at the same time, the blood cells keeps on to increase even after the recovery of anemia. en-copyright= kn-copyright= en-aut-name=OkanoTakuya en-aut-sei=Okano en-aut-mei=Takuya kn-aut-name=岡野卓也 kn-aut-sei=岡野 kn-aut-mei=卓也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=115 end-page=135 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and Clinical Study on the Bone Marrow Transplantation Part 1: Co-relation between the shift of blood picture due to the bone marrow transplantation, iron metabolism and function of reticuloendothelial system kn-title=骨髓埋沒に関する実験的並に臨床的研究 第1編 骨髓埋沒による血液像の変動と鉄代謝及び網内系機能との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Increase of blood cells, decrease of serum iron quantity and a slight degree of over-function of reticuloendothelial system will be induced, by transplantating some suitable amount (Prokg. 0.5g) of bone marrow in a dog's subfascia of femur. This has been caused in urging to utilize the accumulated iron owing to promotion of hematopoetic fanction; if we investigate it about organic iron, when the blood showing an increase, ferritin in the spleen showed a tendency toward decrease, but the deposits of hemosiderin in tissue has proved little alteration from its normal state, Contrary to this, any decrease in serum iron observed under infected state, would rightly be ascribed to the retained stock of iron due to excessive function of reticuloendothelial system, due to protecting infection; esp., what comes from the absorption and deposits of hemosiderin produced along with excited breakage of hemoglobin, or resulted from imperfect utilization of iron, in hematopoetic organs; so that, there is seen certain essential differences between the excessive function of reticulo endothelial system when hematopoetic organs is stimulated, and decrease in serum iron; further, on occasion when hematopoetic function is urged according to the bone marrow transplantation, we could realize that a close connection exists between the iron metabolism and function of reticuloendothelial system: at the same time, could verify partly the mechanism in creating blood cells the occasion. en-copyright= kn-copyright= en-aut-name=OkanoTakuya en-aut-sei=Okano en-aut-mei=Takuya kn-aut-name=岡野卓也 kn-aut-sei=岡野 kn-aut-mei=卓也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=85 end-page=105 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Pathogenesis of Hypoplastic Anemia (Panmyelopathia.) Part 3: Experimental studies of the developmental mechanism of anemia kn-title=再生不良性貧血（汎骨髓病症）の本態に関する研究 第三編 貧血の発生機転に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Having performed various experiments about rabbits of experimental anemia, in order to clarify causes of anemia, by injection of anemia-producing substance, obtained results as follows: 1) As to spleen-extirpated rabbit, it has incurred anemia by injection of serum. 2) The same would take place in case of liver-disturbed rabbit, due to serum injection. 3) No anemia was observed with the same injection, when the reticuloendothelial system was blocked with Indian ink. 4) Injecting the serum at a, nutricia femoris, and investigating the blood picture at v, nutricia femoris discovered a marked decrease both in the number of erythrocytes as well as leucocytes 2 hours later. 5) The serum iron value has proved a rise at the maximum anemic stage, in the successive injection. 6) The myelogram of the rabbit in case of successive injection, indicated a picture of maturation-arrest. 7) By all these facts stated above, it might be said, as for the factor to renderrabbit anemic, blood cell-arrest within bone marrow could be considered on one side, while the disturbance in the parenchym of the bone marrow might be imagined on the other. en-copyright= kn-copyright= en-aut-name=IkedaTakashi en-aut-sei=Ikeda en-aut-mei=Takashi kn-aut-name=池田隆 kn-aut-sei=池田 kn-aut-mei=隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=65 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Pathogenesis of Hypoplastic Anemia (Panmyelopathia.) Part 2: The existence of anemia producing substances in urine, cerebrospinal fluid, and extracts of organs kn-title=再生不良性貧血（汎骨髓病症）の本態に関する研究 第二編 尿，髄液，諸臓器中の催貧血性物質 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied experimentally with the urine, cerebrospinal fluid, and extracts of bone marrow, spleen and the liver and obtained the results as follows;　1) In the urine, there is certain anemia-producing substance which is soluble in alcohol as well as ether, and exists in acid fraction.　2) In the cerebrospinal fluid, some anemia-producing substance could be discovered.　3) The bone marrow, the spleen and the liver have certain anemia-producing substance in their extracts. en-copyright= kn-copyright= en-aut-name=IkedaTakashi en-aut-sei=Ikeda en-aut-mei=Takashi kn-aut-name=池田隆 kn-aut-sei=池田 kn-aut-mei=隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=43 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Pathogenesis of Hypoplastic Anemia (Panmyelopathia.) Part 1: Anemia-producing substance in the serum of patients kn-title=再生不良性貧血（汎骨髓病症）の本態に関する研究 第一編 血清中の催貧血性物質 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) If inject serum of this disease in rabbits, in every cases where injected once, as well as 7-times-continued case, haemoglobin, erylhrocytes, as well as platelet indicate a marked decrease. 2) No anemia-producing substance will be seen in serum either of healthy person or of posthemorrhagic anemic patient. 3) Those anemia producing substances found in the patient of this disease proved soluble both for alcohol as well as ether. 4) These substances exist in acid fraction. 5) These substances have the thermostable character for the 30 minutes heating of 100°C. en-copyright= kn-copyright= en-aut-name=IkedaTakashi en-aut-sei=Ikeda en-aut-mei=Takashi kn-aut-name=池田隆 kn-aut-sei=池田 kn-aut-mei=隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=29 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of the Bone-Marrow Autolysate on Medullary Hematopoiesis Part III: Experiment in adding the Autolysate to Bone-Marrow Tissue Culture kn-title=骨髓自家融解液の骨髓造血に及ぼす影響 第3編 骨髄体外組織培養への添加実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author, about the improvement of bone-marrow hematopoiesis, presumed in Part I that the blood vessel function might be one cause; in Part II, concluded that the reticuloendotherial system should be sound a prior, and as was told in the so-called "autohormone theory" it might be due to the particular hormone-like function which is proper to that extract. Accordingly, in this part, in order to exactly verify whether the bone-marrow extract would be influenced directly to the medullary parenchymal Hematopoiesis or not, the author added that extract to bone-marrow tissue culture and inspected its growth rate, wandering velosity, and changes in quantity of hemoglobin as well as in number of blood cells. First, taking observations of the growth rate of bone-marrow tissue, and the wandering velocity of intramedullary pseudoeosinocytes, under culture in cover slips, it was known that the addition of extract in a proper density improves remarkably the growth of tissue, and that the main purport of its growing process roughly coincides with non-added case as well as with controls. Also, the wandering velocity as well as time of continuance of the pseudoeosinocytes, though it was remarkably inhibited when the extract proved very dense, almost receive no other influence, and no significant differences with the controls could be discovered; i.e., the author could perceive that the increase in tissue growth rate by adding the bone-marrow extract was no result of activation of cell wandering, but it owes to the stimulation of growth in parenchymal cells themselves. Moreover, taking observation of the effect of bone marrow extract on the increase of hemoglobin as well as red blood cell number, under the culture in fluid medium, it was clarified that a certain of extract in a proper density brought about a marked increase in the amount, proving the existence of direct function by the extract. All through 3 reports the author have vindicated the fact that the improvement of medullary hematopoiesis by parenteral administration of so-called bone-marrow substances, may be caused not only by the vessel function, but also by the function of bone-marrow substance which has power to advance hematopoietic function. en-copyright= kn-copyright= en-aut-name=FujiiMasatomi en-aut-sei=Fujii en-aut-mei=Masatomi kn-aut-name=藤井昌富 kn-aut-sei=藤井 kn-aut-mei=昌富 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=13 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of the Bone-Marrow Autolysate on Medullary Hematopoiesis Part II: Influence of bone-marrow autolysate under splenectomy, liver parenchymal disturbance or reticuloendotherial blockade kn-title=骨髓自家融解液の骨髓造血に及ぼす影響 第2編 剔脾，肝障碍，網内糸填塞の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the previous report, the author stated that there should happen a remarkably stimulated medullary hematopoiesis if the intra-abdominal injection of bone-marrow extract were successively rendered for a normal rabbit; this time, I conducted the following experiments in order to clarify whether these phenomena would activate indirectly through liver, spleen, or reticuloendotherial syetem, which are said to keep close relation with hematopoiesis, or, as Miyakawa maintained in this so-called "autohormone tbeory", functionate directly. First, having successively injected "bone-marrow extract" at 48 hours as well as 7 days after the splenectomy, the author examined its peripheral blood picture: this time, as was seen in the case of normal rabbit, biphasic blood cell increase was observed to take place, and an increase of reticulocytes number as well as a left shift of leucocytes were observed conspicuously, under the secondary blood cell increase. Consequently, it was verified that the same extract could stimulated the medullary hematopoiesis even under the influence of splenectomy. Next, by injecting likewise at 24 hours after the liver parenchymal disturbance, biphasic blood cell increase, an increase of reticulocytes number, and a left shift of leucocytes were noticed; moreover, even in case when the functions both of liver and spleen were removed at the same time, almost the same result as in the normal rabbit was obtained. In case the reticuloendotherial system was blocked with India-ink, even successive injection could not cause either increase of blood cell as well as left shift of leucocyte or improvement of intramedullary blood stream; that is to say, no medullary hematopoiesis was brought about. From the above results, the author concludes that the improvement of medullary hematopoiesis by successive intraabdominal injection of bone-marrow extract has no concern with either splenectomy or liver parenchymal disturbance, that the soundness of bone-marrow reticuloendotherial system should be indispensable requisite, and that this phenomenon might occur owing to the direct stimulation to bone-marrow parenchymal function. en-copyright= kn-copyright= en-aut-name=FujiiMasatomi en-aut-sei=Fujii en-aut-mei=Masatomi kn-aut-name=藤井昌富 kn-aut-sei=藤井 kn-aut-mei=昌富 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=1 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of the Bone-Marrow Autolysate on Medullary Hematopoiesis Part I: Intra-abdominal injection and test of artificial circulation through the femur kn-title=骨髓自家融解液の骨髓造血に及ぼす影響 第1編 腹腔内注射並に骨髄灌流実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author, as a link in the serial study on improvement of medullary hematopoiesis by so-called bone-marrow substance, tried to investigate both effects and functions of parenteral administration of rabbit's red bone-marrow autolysate (called simply as "bone-marrow extract" hereafter); so that, having injected its certain amount into normal rabbit's abdominal cavity, the author inspected its hourly effect on peripheral blood picture as well as on blood picture of V. nuturitica femoralis, and also took observations of certain changes that occurred to intramedullary circulation. As a result, the author discovered that: 1) the biphasic blood cell increase was induced in both cases of single and successive injection alike; 2) in its secondary blood cell increase, the increase was more remarkable in case of successive, than in case of single, injection; 3) above all, an increase of reticulocytes, a comparative increase of pseudoeosinocytes, and a left shift of leucocytes, were remarkably induced. Moreover, in case of the primary blood cell increase, an expansion of medullary nutric vessels, a marked blood cell increase in nutric veinal blood, and a comparative increase of pseudoeosinocytes --- i. e. a liberation of accumulated blood cells within bone-marrow --- were brought about; and further, the blood stream within bone-marrow under the two phases of blood cell increase was noticed to be remarkably stimulated, as compared with the case in normal rabbit. From the above results, it may roughly be said that, in case the bone-marrow extract should be intraabdominally injected, a biphasic blood cell increase occures in both cases of single and successive injection, the latter being more powerful in stimulating medullary hematopoiesis; and that the primary blood cell increase is caused by the mobilization as well as the liberation of accumulated blood cells which is due to the stimulation to blood stream within bone-marrow, while the secondary blood cell increase owes much to the hematopoietic function of bone-marrow which is originated in the continuance of stimulation to blood stream within bone-marrow. en-copyright= kn-copyright= en-aut-name=FujiiMasatomi en-aut-sei=Fujii en-aut-mei=Masatomi kn-aut-name=藤井昌富 kn-aut-sei=藤井 kn-aut-mei=昌富 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=11 article-no= start-page=2157 end-page=2166 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19561130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Sympathic Control of the Bone Marrow Part III The change of peripheral blood picture after the lumbal sympathectomy kn-title=骨髓の神経性調節に関する研究 第三編 腰部交感神経幹切除後の末梢血液像の変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The change of periphral blood picture was relalively examined after the lumbal sympathectomy and even operation by no sympathectomy of dogs, and the results obtained were as follows: 1) No shortened the recovery from the decrease of hemoglobine and erythrocyte count. 2) No reduced the decrease of hemoglobin, but reduced clearly decrease of erythrocyte count. 3) Inconstant about leukocyte count. 4) Inconstant about staff neutrophils, but reduced the increase of total neutrophils. The above concludes that the interception of sympathic nerve of dogs promotes the increase of erythrocytes and represses the increase of neutrophils in peripheral blood. en-copyright= kn-copyright= en-aut-name=ShibataTamotsu en-aut-sei=Shibata en-aut-mei=Tamotsu kn-aut-name=柴田完 kn-aut-sei=柴田 kn-aut-mei=完 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=11 article-no= start-page=2141 end-page=2155 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19561130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Sympathic Control of the Bone Marrow Part II The change of blood picture in nutrient vessel of femur after the lumbal sympathectomy kn-title=骨髓の神経性調節に関する研究 第二編 腰部交感神経幹切除の大腿骨栄養静脈血像の変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The change of blood picture in nutrient vessel of femur was examined after the lumbal sympathectomy of rabbits and the results obtained were as follows: 1) Promoted cell outswim of erythrocytes and reticulocytes. 2) Promoted cell outflow of pseudoeosinophils especially staff cells. 3) Can be cases of macroscopic dilatation of the vessel. 4) Increased blood stream volume. The above concludes that the interception of sympathic nerve of rabbits dilates the intramedullary vessels, and promotes those blood streams, cell outflow from the bone marrow. en-copyright= kn-copyright= en-aut-name=ShibataTamotsu en-aut-sei=Shibata en-aut-mei=Tamotsu kn-aut-name=柴田完 kn-aut-sei=柴田 kn-aut-mei=完 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=11 article-no= start-page=2117 end-page=2139 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19561130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Sympathic Control of the Bone Marrow Part 1 The change of femur bone marrow picture after the lumbal sympathectomy kn-title=骨髓の神経性調節に関する研究 第一編 腰部交感神経幹切除後の大腿骨々髄像の変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The change of femur bone marrow picture was examined after the lumbal sympathectomy of rabbits and dogs, and the results obtained were as follows: 1) No changes by macroscopic finding. 2) No changes of nucreated cell count. 3) Relatively increasing of erythroblasts, and decreasing of pseudoeosinphils (rabbits) or neutrophils (dogs), but those mitosis count both increased. 4) Erythroblasts, pseudoeosinophils (rabbits) and neutrophils (dogs) all indicated marrowright-shift, in other words, the promotion of the maturity. 5) Staff and lobed pseudoeosinophils (rabbits) or neutrophils (dogs) indicated decrease, in other words, the promotion of cell outswim or cell outflow. The above concludes that the intercreption of sympathic nerves of rabbits and dogs promotes mainly medullary cell outflow and maturiy. en-copyright= kn-copyright= en-aut-name=ShibataTamotsu en-aut-sei=Shibata en-aut-mei=Tamotsu kn-aut-name=柴田完 kn-aut-sei=柴田 kn-aut-mei=完 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=11 article-no= start-page=1981 end-page=1987 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19561130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Inorganic Salt content in the Cat's Brain with Latent Cerebral Local Anaphylaxis. PART Ⅱ. Natrium, magnesium and chlorine contents in the cat's brain with latent cerebral local anaphylaxis. kn-title=メチルパラチオンの毒性―エチルパラチオンと比較して― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The toxicity of emulsified methylparathion was examined in comparison with ethylparathion. i) The LD(50) of methylparathion given orally to mice was 19.4-30.5 mg/kg and its mean value was 25.4mg/kg. (LD(50) of ethylparathion was 11.5mg/kg) The approximate LD(50) of methylparathion (ethylparathion) for the rabbit was 40-50 (8-10) by subcutaneous injection, 50-60 (20) by oral route and 200-400 (50-100) by dermal application. Thus, methylparathion was about 1/2-1/3 as toxic as ethylparathion. ii) The manifestations produced by methylparathion administration for rabbits were similar to those by ethylparathion. In addition, it was noted that the rabbits Ìn moderately poisoned cases were led to death after a week from malnutrition accompanied with anorexia and diarrhea. iii) The inhibitory action of methylparathion on the rabbit blood cholinesterase in vitro, was about 1/2-1/3 as great as that of ethylparathion. iv) In the laboratory rabbit there occurced leucocytosis, mainly occupied by pseudoeosinophils, and the deflection of Arneth count to the left as well as relative lymphocytopenia was observed. en-copyright= kn-copyright= en-aut-name=NambaTatsuji en-aut-sei=Namba en-aut-mei=Tatsuji kn-aut-name=難波達治 kn-aut-sei=難波 kn-aut-mei=達治 aut-affil-num=1 ORCID= en-aut-name=YamadaMinoru en-aut-sei=Yamada en-aut-mei=Minoru kn-aut-name=山田稔 kn-aut-sei=山田 kn-aut-mei=稔 aut-affil-num=2 ORCID= en-aut-name=NakazawaTakeshi en-aut-sei=Nakazawa en-aut-mei=Takeshi kn-aut-name=中沢彪 kn-aut-sei=中沢 kn-aut-mei=彪 aut-affil-num=3 ORCID= en-aut-name=OkadaYoshio en-aut-sei=Okada en-aut-mei=Yoshio kn-aut-name=岡田由夫 kn-aut-sei=岡田 kn-aut-mei=由夫 aut-affil-num=4 ORCID= en-aut-name=NakayamaAkitoshi en-aut-sei=Nakayama en-aut-mei=Akitoshi kn-aut-name=中山章壮 kn-aut-sei=中山 kn-aut-mei=章壮 aut-affil-num=5 ORCID= en-aut-name=YoshikayaKiyoshi en-aut-sei=Yoshikaya en-aut-mei=Kiyoshi kn-aut-name=吉川潔 kn-aut-sei=吉川 kn-aut-mei=潔 aut-affil-num=6 ORCID= en-aut-name=KimuraTakashi en-aut-sei=Kimura en-aut-mei=Takashi kn-aut-name=木村峻士 kn-aut-sei=木村 kn-aut-mei=峻士 aut-affil-num=7 ORCID= en-aut-name=MaedaAkira en-aut-sei=Maeda en-aut-mei=Akira kn-aut-name=前田昭 kn-aut-sei=前田 kn-aut-mei=昭 aut-affil-num=8 ORCID= en-aut-name=ShiromotoTetsuzo en-aut-sei=Shiromoto en-aut-mei=Tetsuzo kn-aut-name=城本鉄蔵 kn-aut-sei=城本 kn-aut-mei=鉄蔵 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=11 article-no= start-page=2749 end-page=2756 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19571130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Japanese B Encephalitis with the Radioactive P(32) Part 3 Investigation Of Nucleic Acid Metabolism in the Organs, especially in Brain And Liver, of Mice Inoculated Intraperitoneally with Japanese B Encephalitis Virus from the Viewpoint of the Specific kn-title=P(32)による実験的日本脳炎の研究 第三編 腹腔内病毒接種マウス臓器（脳，肝）に於ける核酸代謝の核酸燐比放射能による研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nucleic acid metabolism in brain and liver, which had been formerly investigated by the measurement of P(32) activity, was examined from the viewpoint of the specific activity of P(32) in order to make clear the nucleic acid metabolism in its progressive form. As in my last experiment, Japanese B Encephalitis Virus was intraperitoneally inoculated. P(32) was intraperitoneally injected into the mice respectively 48 and 120 hours after they were inoculated with the virus, and after 6 and 24 hours, the nucleic acid metabolism in brain and liver was observed from the point of view of the P(32) specific activity. As the control objects, the healthy mice injected intraperitoneally with P(32) were used. An increase of the P(32) specific activity in liver was recognized during the incubation period, especially in its earlier stage. This fact, as Osada once reported, seems to imply that rapid metabolic changes of the nucleic acid in liver take place during the incubation period or the so-called visceral phase of Japanese B Encephalitis. The P(32) specific activity in liver at the later stage of infection decreases in spite of the increase of nucleic acid amount; and the ups and downs in nucleic acid amount does not always go parallel with the P(32) specific activity. en-copyright= kn-copyright= en-aut-name=MatsuhisaMitsuo en-aut-sei=Matsuhisa en-aut-mei=Mitsuo kn-aut-name=松久光雄 kn-aut-sei=松久 kn-aut-mei=光雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=9 article-no= start-page=2433 end-page=2454 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hematopoietic Functions of the Bone Marrow in the Cases Irradiated with Ultra-short Waves on the Diencephalon Part 3 Therapeutic Effects of the Irradiation of Ultra-short Waves in the Rabbits with Experimental Anemia and in the Patients with Hypoplastic Anemia kn-title=超短波間脳照射の骨髄造血機能に及ぼす影響 第三編 実験的貧血家兎恢復に及ぼす影響並に再生不良性貧血患者に於ける臨牀実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The following results were obtained in the study of the rabbits with experimental anemia and the patients with hypoplastic anemia both treated with ultra-short waves in the Diencephalon. 1) In the rabbits with experimental anemia induced by the venesection of blood, the phenylhydrazine and benzol intoxication, the period of time for the recovery of anemia was shortened in the cases with the treatment of ultra-short waves faster than in the cases without treatment. 2) In the rabbits with anemia induced by the venesection of blood and the phenylhydrazine intoxication, the bone marrow function were accelerated by successive irradiations sooner than by a single irradiation. 3) In one of three Patients with hypoplastic anemia some effect from the treatment was observable. en-copyright= kn-copyright= en-aut-name=FujimoriAkira en-aut-sei=Fujimori en-aut-mei=Akira kn-aut-name=藤森明良 kn-aut-sei=藤森 kn-aut-mei=明良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=9 article-no= start-page=2413 end-page=2431 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hematopoietic Functions of the Bone Marrow in the Cases Irradiated with Ultra-short Waves on the Diencephalon Part 2 Hematopoietic Functions in the Cases with Splenectomy, Liver Disturbance, Splenectomy with Liver Disturbance, Reticuloendotherial Blocking, the Section of Splanchnic Nerve in Liver Branch and S kn-title=超短波間脳照射の骨髄造血機能に及ぼす影響 第二編 剔脾，肝障碍，剔脾兼肝障碍，網内系填塞，内臓神経肝臓枝，脾臟枝並に小内臓神経副腎枝切断の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rabbits with splenectomy, liver disturbance, reticuloendotherial blocking and the section of the splanchnic nerve were irradiated with ultra-short waves on the Diencephalon for 3 minutes and the behavior of the blood flow and the mobilization of blood cells in the bone marrow were observed. The following are the results. 1) The acceleration of blood flow and the mobilization of blood cells in the bone marrow caused by 3 minutes' irradiation showed no difference between the normal rabbits and the rabbits with such procedures as splenectomy, liver disturvance or the section both of the splanchnic nerve in liver and in spleen branch and the lesser splanchnic nerve in suprarenal branch. 2) In the rabbits with reticuloendotherial blocking by carbon particles, blood flow in the bone marrow was likewise accelerated but the mobilization of blood cells in the bone marrow was not enhanced. en-copyright= kn-copyright= en-aut-name=FujimoriAkira en-aut-sei=Fujimori en-aut-mei=Akira kn-aut-name=藤森明良 kn-aut-sei=藤森 kn-aut-mei=明良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=9 article-no= start-page=2391 end-page=2412 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hematopoietic Functions of the Bone Marrow in the Cases Irradiated with Ultra-short Waves on the Diencephalon Part 1 Blood Cell Mobilization and Depot in the Bone Marrow Induced by the Irradiation of Ultra-short Waves on the Diencephalon kn-title=超短波間脳照射の骨髄造血機能に及ぼす影響 第一編 超短波間脳照射による骨髄の血球動員並に抑留に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=By irradiatied rabbits with ultra-short waves on the diencephalon under various conditions, observations on the blood picture in the femur nutrient vein were carried out and the condition of the blood circulation in the bone marrow were measured. At the same time obtaining histological findings and performing the tissue culture of the bone marrow, the following results were obtained. 1) Following the 3 minutes' irradiation, the blood cells in the bone marrow were mobili zed by the acceleration of blood flow in the bone marrow, and scarecely no change of the hematopoietic functions could be observed. After 24 hours, however, the function rose remarkably as the secondary phenomenon of the acceleration of blood flow. 2) Though in the cases wtih successive irradiations every 3 minutes, the increase of both blood cells in peripheral blood and hematopoietic functions of the bone marrow increased but not to the degree mentioned previously. The intensity of acceleration of blood flow and the mobilization of blood cells in the bone marrow in every irradiation were left in about the same degree as in the previous cases. 3) By 30 minutes' irradiation, the bone marrow blood flow was slackened and the blood cells were stored in the bone marrow revealing histologically the depot of blood cells, but the hematopoietic functions remained unaffected. 4) The effect of hookworm toxin generally appearing was reduced to a slight and only transient depot of blood cells in the bone marrow after three minutes' irradiation in the case receiving the human serum with hookworm anemia into the bone marrow circulation. en-copyright= kn-copyright= en-aut-name=FujimoriAkira en-aut-sei=Fujimori en-aut-mei=Akira kn-aut-name=藤森明良 kn-aut-sei=藤森 kn-aut-mei=明良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=9 article-no= start-page=2333 end-page=2344 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Resistance of Hookworm Larvae Part 4 Resistance of Hookworm Larvae to Human Gastric Juice kn-title=鉤虫仔虫の抵抗性に関する実験的研究 第四編 鉤虫仔虫の胃液に対する抵抗性について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influence of human gastric juice with various degrees of acidity to hookworm larvae was systematically observed for a long period of time. The results are as follows. 1) At 37°C human gastric juice was denatured so that it was impossible to make such a study at this temperature. 2) Even with the addition of streptmycine and penicillin the denaturation of gastric juice at 37°C could not be controlled, but rather accerelated. 3) At the temperature of refrigerated room the lethality of the larvae of Anchylostoma caninum in gastric juice was in proportion to the length of time and to its acidity, but was extremely low. 4) Thus it was concluded that the human gastric juice even with very high acidity cannot prevent the oral infection of the matured hookworm larvae. In other words, oral susceptibility of human to hookworm is not influenced by gastric juice. 5) At a refrigerated-room temperature the ecdysis rate of the larvae of Anchylostoma caninum in gastric juice increased in inverse proportion to the acidity. en-copyright= kn-copyright= en-aut-name=TakedaKatsumi en-aut-sei=Takeda en-aut-mei=Katsumi kn-aut-name=武田勝美 kn-aut-sei=武田 kn-aut-mei=勝美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=9 article-no= start-page=2321 end-page=2332 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Resistance of Hookworm Larvae Part 3 Resistance of Hookworm Larvae to Artificial Gastric Juice kn-title=鉤虫仔虫の抵抗性に関する実験的研究 第三編 鉤虫仔虫の人工胃液等に対する抵抗性について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In vitro studies were made on the resistance of the larvae of both Anchylostoma Dubini and Anchylostoma caninum to artificial gastric juice and to some fraction of it at 37°C, and the following results were obtained. 1) The greater the concentration of hydrochloric acid of the artificial gastric juice the shorter the period of time to death of the larvae in the juice. It took, however, nine days to the death of larvae even in gastric juice with the concentration of hydrochloric acid as high as that of hyperacidity. 2) Lactic acid at high concentration acted injuriously on the larvae but at the concetration equal to human gastric juice it had practically no influence on the larvae. 3) Pepsin at higher concentration was slightly harmful but at lower concentration it was rather beneficial to the larvae. 4) The resistance of the both larvae, Anchylostoma Dubini and Anchylostoma caninum showed hardly no difference. en-copyright= kn-copyright= en-aut-name=TakedaKatsumi en-aut-sei=Takeda en-aut-mei=Katsumi kn-aut-name=武田勝美 kn-aut-sei=武田 kn-aut-mei=勝美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=9 article-no= start-page=2309 end-page=2319 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Resistance of Hookworm Larvae Part 2 Influence of Two Cholinergic Agents and Parathion on Hookworm Larvae kn-title=鉤虫仔虫の抵抗性に関する実験的研究 第二編 自律神経麻痺並に遮断剤及び同剤添加Parathion液の鉤虫仔虫に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied the influence of Atropine, Ace and Parathion on the larvae of Anchylostoma caninum mainly on the movement. The following are the results. 1) Both Atropine and Ace acted on the larvae as nerve toxic, and the former was more toxic than the latter. Both of 0.01% solution, however, prolonged the duration of the time of movement up to coming to standstill in comparison with the control. 2) Both Atropine and Ace relieved the symptom of Parathion poisoning in the larvae and prolonged the life. 3) There might be the acetylcholine-transmission in the impulseconductiön of the nervous system of the larvae, and the movement of the larvae might be intimately associated with the functions of the nervous system. en-copyright= kn-copyright= en-aut-name=TakedaKatsumi en-aut-sei=Takeda en-aut-mei=Katsumi kn-aut-name=武田勝美 kn-aut-sei=武田 kn-aut-mei=勝美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=9 article-no= start-page=2291 end-page=2307 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Resistance of Hookworm Larvae Part 1 Resistance of Hookworm Larvae to Alkylphosphate Insecticides kn-title=鉤虫仔虫の抵抗性に関する実験的研究 第一編 有機燐農薬に対する鉤虫仔虫の抵抗性について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In vitro studies were made on resistance of the larvae of Anchylostoma caninum against alkylphosphate insecticides, Parathion, Diazinon, Chlorthion and ACC 4124 (Sumicide). The results were as follows. 1) In the emulsions of Parathion, Diazinon, Chlorthion and sumicide, having the concentration over 10-5 %, 10-3%, 10-3% and 10-2% respectively, most of the larvae died within four days. This indicated that these alkylphosphates were in some degree possible to prevent hookworm diseases due to the toxity to the larvae, when sprayed in the field. 2) Hookworm larvae in contact with alkylphsphates, nerve toxin, were lead to death after showing abnormal movement. The stages to death may be divided into stage of incubation, convulsion, ataxia, palsy and death. 3) Microscopically the bodies of dead larvae were observed to be of minute or moderate granular degeneration, and consequently internal components were not discernible. 4) In the alkylphosphate emulsions, the larvae moulted quite rapidly. 5) With the lapse of time both lethality and the rate of ecdysis increased in parallel correlation, while the count of the head movement of larvae per minute was in inverse proportion to them. en-copyright= kn-copyright= en-aut-name=TakedaKatsumi en-aut-sei=Takeda en-aut-mei=Katsumi kn-aut-name=武田勝美 kn-aut-sei=武田 kn-aut-mei=勝美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=8 article-no= start-page=2203 end-page=2216 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Sympathetic Interception on the Bone Marrow Part III. Femur Bone Marrow Culture in Fluid Medium after the unilateral lumbar Sympathectomy on Rabbits kn-title=交感神経遮断の骨髓に及ぼす影響 第3編 骨髄体外液体培養法による研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Increase rates of erythrocytes and of heomoglobine of the rabbit's femur bone marrow on every 3rd., 5th, 10th, 20th, 30th and 60th days affer the unilateral Iumbar sympa the ctomy in fluid medium culture were examined. The results obtained were as follows:- (1) The maximum increase rate of erythrocytes did not occur till 5th or 10th day after the denervation, and the value fell progressively till 60th day. (2) The rate of hemoglobine showed its maximum on the 3rd. or 5th day after the operation, then decreased till both day, in which showed very little differences between both sides. (3) In most cases, increase rates of erythrocytes and of hemoglobine did not exceed over 20 percents. In concusion. the sympathetic denervation promotes the function of rabbit's bone marrow, but it only lasts a short while. This may have been due to the inerease of blood flow in the bone marrow, and secondarily it caused the hyperfunction of the bone marrow. en-copyright= kn-copyright= en-aut-name=NagaseMasaki en-aut-sei=Nagase en-aut-mei=Masaki kn-aut-name=永瀬正己 kn-aut-sei=永瀬 kn-aut-mei=正己 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=8 article-no= start-page=2191 end-page=2201 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Sympathetic Interception on the Bone Marrow Part II. Respiration and anaerobe Glycolysis of Femur Bone Marrow after the unilateral lumbar Sympathectomy on Rabbits kn-title=交感神経遮断の骨髓に及ぼす影響 第2編 骨髄の呼吸解糖作用測定に依る研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Respiration and anaerobe glycolysis of femur bone marrows of unilateral sympathectomized rabbits were compaired with each other side on the following 3, 5, 10, 20, 30 & 120 days after the operation with the direct method of the Warburg constant volume respirometer. The results obtained were as follows: 1) The respiration (Q(O(2))) showed no remarkable differencs between each other. 2) The anaerobe glycolysis (Q(M)(N(2))) showed significant value on the operated side in 5th, 10th and 20th day groups after the operation, but transitory. So the interception of the sympathetic in rabbits promotes the function of the bone marrow. In the other word the sympathetic reduces the function of the bone marrow. en-copyright= kn-copyright= en-aut-name=NagaseMasaki en-aut-sei=Nagase en-aut-mei=Masaki kn-aut-name=永瀬正己 kn-aut-sei=永瀬 kn-aut-mei=正己 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=8 article-no= start-page=2175 end-page=2190 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Sympathetic Interception on the Bone Marrow Part. I. Cultures in Coverships of Femur Bone Marrow after the unilateral lumbar Sympathectomy kn-title=交感神経遮断の骨髓に及ぼす影響 第1編 骨髄被覆培養法に依る研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cultures in coverslips of femur bone marrows of unilateral sympathectomized rabbits were compaired with each other side on the following 3, 5, 10, 15, 20, 30 and 90 days. The results obtained were as follows: (1) The wandering velocity of neutrophils of bone marrow of the sympathectomized side is larger than the another side, especially on the 5 th day after the operation. (2) The relative growth rate is larger than the other non-operated side on the 5 th and 10 th days after the operation. (3) The cell dencity is strikingly larger in the sympathectomized side on its 3rd, 5th, 10 th and 30th day groups after the operation. (4) Each figures show the maximum on about 5th day group after the operation, and after 30 days the results did not appear to differ between both sides, and these effects are transitory. Thus the interception of the sympathetic in rabbits promotes the function of the bone marrow transitorily. In other words the sympathetic reduces the function of the bone marrow. en-copyright= kn-copyright= en-aut-name=NagaseMasaki en-aut-sei=Nagase en-aut-mei=Masaki kn-aut-name=永瀬正己 kn-aut-sei=永瀬 kn-aut-mei=正己 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=8 article-no= start-page=2169 end-page=2173 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Iron and Copper Metabolisms in Hookworm Anemia kn-title=鉤虫症貧血に於ける血清鉄,銅量並びに臓器銅の態度 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The authors studied the iron and copper metabolisms in dogs and patients with hookworm anemia, and obtained the following results. 1) In hookworm anemia, serum iron was low in a parallel correlation with the severity of anemia as other iron deficiency anemias. Hookworm anemia, however, was different from other iron deficiency anemias in that it was accompanied by the reduction of serum copper in severe cases. Thus, Fe/Cu was also lower. 2) In the treatment of hookworm with vermicide, serum iron and copper together with Fe/Cu were restored first and afterwards followed the recovery of anemia. 3) The amount of tissue copper of animals increased in the cases of dog with hookworm anemia and in the cases of rabbit being intravenously injected with serum of dog with hookworm anemia. The increase was obvious in the liver and spleen. en-copyright= kn-copyright= en-aut-name=KitazimaKazuo en-aut-sei=Kitazima en-aut-mei=Kazuo kn-aut-name=喜多島和男 kn-aut-sei=喜多島 kn-aut-mei=和男 aut-affil-num=1 ORCID= en-aut-name=SogawaTamotsu en-aut-sei=Sogawa en-aut-mei=Tamotsu kn-aut-name=十川保 kn-aut-sei=十川 kn-aut-mei=保 aut-affil-num=2 ORCID= en-aut-name=NaitoTakakazu en-aut-sei=Naito en-aut-mei=Takakazu kn-aut-name=内藤孝和 kn-aut-sei=内藤 kn-aut-mei=孝和 aut-affil-num=3 ORCID= en-aut-name=AsanoKenwo en-aut-sei=Asano en-aut-mei=Kenwo kn-aut-name=浅野健夫 kn-aut-sei=浅野 kn-aut-mei=健夫 aut-affil-num=4 ORCID= en-aut-name=HondaSeiken en-aut-sei=Honda en-aut-mei=Seiken kn-aut-name=本多正憲 kn-aut-sei=本多 kn-aut-mei=正憲 aut-affil-num=5 ORCID= en-aut-name=SuizuAkira en-aut-sei=Suizu en-aut-mei=Akira kn-aut-name=水津昭 kn-aut-sei=水津 kn-aut-mei=昭 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=8 article-no= start-page=2085 end-page=2095 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Influences Exerted on the Bone Marrow by the Blocking of Parasympathetic Nerves Part 3 Influences on the Bone Marrow Culture of the Lower Extremeties in Fluid Medium by Sectioning Posterior Root of Lumbosacral Segments of Spinal Cord of Dog kn-title=副交感神経遮断の骨髄に及ぼす影響に関する研究 第三編 犬腰仙部脊髄後根切除の下肢骨髄液体培養に及ぼす影響 附. 全編の総括 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By sectioning the posterior roots of the fifth, sixth, and seventh lumbar regions of spinal cord as well as the first sacral segment, the author studied the influences on the bone marrow culture of lower extremeties in fluid medium on the left side of young dog, comparing these with those on the right side as the control; and obtained the following results: 1) The rate of increase in erythrocytes falls as compared with that of the control. 2) The rate of increase in hemoglobin content likewise decreases as compared with that of the control. From the above the author arrived at the conclusion that the blocking of the parasympathetic nerves induces the lowering of erythropoieic functions in the bone marrow parenchyma. en-copyright= kn-copyright= en-aut-name=IshidaShusaku en-aut-sei=Ishida en-aut-mei=Shusaku kn-aut-name=石田收作 kn-aut-sei=石田 kn-aut-mei=收作 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=8 article-no= start-page=2073 end-page=2083 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Influences Exerted on the Bone Marrow by the Blocking of Parasympathetic Nerves Part 2 Influences on the Bone Marrow Culture of the Femur with Cover-Slip Method by Blocking Lumbosacral Segments of Spinal Cord of Dog kn-title=副交感神経遮断の骨髄に及ぼす影響に関する研究 第二編 犬腰仙部脊髄後根切除の大腿骨々髄被覆培養に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By sectioning the posterior roots of the fifth, sixth, and seventh lumbar regions of spinal cord as well as the first sacral segment on the left side of young dog, the author has studied the influences on the bone marrow culture of the femur with cover-slip method, comparing those on the right side as the control; and obtained the following results: 1) The relative value of growth area is lower as compared with that of the control. 2) Cell density is likewise lower than that of the control. 3) There is a tendency of lowering in wandering velocity as compared with that of the control. From these the author would conclude that the blocking of parasympathetic nerves brings about the lowering of the functions leucopoiesis in the marrow parenchyma. en-copyright= kn-copyright= en-aut-name=IshidaShusaku en-aut-sei=Ishida en-aut-mei=Shusaku kn-aut-name=石田收作 kn-aut-sei=石田 kn-aut-mei=收作 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=8 article-no= start-page=2049 end-page=2072 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Influences Exerted on the Bone Marrow by the Blocking of Parasympathetic Nerves Part 1 Influences on the Picture of the Bone Marrow Obtained from the Lower Extremeties by Section of Lumbosacral Posterior Root of Spinal Cord of Dog kn-title=副交感神経遮断の骨髄に及ぼす影響に関する研究 第一編 犬腰仙部脊髄後根切除の下肢骨髄像に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By cutting off the posterior roots of the fifth, sixth and seventh lumbar regions of spinal cord as well as of the first sacral segment, on the left side of young dog, the author studied the changes in the bone marrow picture of the lower extremeties comparing that on the right side as the control, and obtained the following results: 1) No marked change can be recognized in macroscopic findings of the bone marrow in the femur and tibia. 2) In the bone marrow of the femur there is a tendency of a slight decrease in the number of nucleated cells as compared with that on the side of the control. 3) In the bone marrow of the tibia, though no difference can be recognized between erythrocytes and neutrophils, in the femur bone marrow erythrocytes have relatively decreased but neutrophils have increased as compared with those of the control. 4) There is a tendency of a decrease in the mitoses of erythrocytes and neutrophils as compared with those on the side of the control. 5) Both erythrocytes and neutrophils as compared with those on the side of the control present a picture of a shift to the left, namely, an inhibition of maturation. 6) Segmented neutrophils have increased in number as compared with the control, indicating an inhibition of the cell outflow from the bone marrow. From these the author arrived at the conclusion that the blocking of parasympathetic nerves primarily inhibits the cell outflow from the bone marrow and accompanying this, cell maturation is also inhibited in the parenchyma of the bone marrow. en-copyright= kn-copyright= en-aut-name=IshidaShusaku en-aut-sei=Ishida en-aut-mei=Shusaku kn-aut-name=石田收作 kn-aut-sei=石田 kn-aut-mei=收作 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1925 end-page=1932 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Parathion Poisoning Part 4. The Function of the Reticulo-endotherial System in Parathion Poisonig kn-title=パラチオン中毒に関する研究 第4編 パラチオン中毒の網内系機能に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the rabbits, dogs and patients with parathion poisoning, the function of the reticulo-endotherial system was examined by means of carbon black phagocytosis (Sugiyama) and congo-red test (Adler & Reimann). Results are as follows: 1) In the acute parathion poisoning, the function of the reticulo-endotherial sytem presented itself the disturbances such as the decrease of phagocytosis and the increase of congo-red index at the early stage of the poisoning. 2) With daily injection of small doses of parathion, similar disturbances ever noted, and lasted longer. 3) The recovery of the function of the reticulo-endotherial system was similar to that of blood cholinesterase activity. en-copyright= kn-copyright= en-aut-name=TanimotoHajime en-aut-sei=Tanimoto en-aut-mei=Hajime kn-aut-name=谷本一 kn-aut-sei=谷本 kn-aut-mei=一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1915 end-page=1924 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Parathion Poisoning Part 3. Parathion poisonig in Experimental Anemias kn-title=パラチオン中毒に関する研究 第3編 貧血家兎に於けるパラチオン中毒 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the rabbits with bleeding anemia, the red cell cholinesterase was inhibited following subcutaneous injection of 10 mg/kg parathion as in the cases of normal rabbits, while the recovery of red cell cholinesterase was faster and greater than that of the normal, and moreover, it was estimated to be above the normal value. Changes of serum cholinesterase activity was the same as those of red cell cholinesterase. On the contrary, in the rabbits with anemia induced by repeated injections of bezol, slower recovery of red cell cholinesterase was observed, but the serum cholinesterase activity was similar to that of the control. In both these anemic cases, almost no difference in LD(50) of parathion could be detected. en-copyright= kn-copyright= en-aut-name=TanimotoHajime en-aut-sei=Tanimoto en-aut-mei=Hajime kn-aut-name=谷本一 kn-aut-sei=谷本 kn-aut-mei=一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1909 end-page=1914 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Parathion Poisoning Part 2. Parathion Poisoning in Experimental Liver Injury kn-title=パラチオン中毒に関する研究 第2編 肝障碍家兎に於けるパラチオン中毒 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using the rabbits whose liver had been been injured with injection of 20% CCl(4) in oliveoil (1 cc/kg) every two days and administering parathion 24 hours after the third CCl(4) injection, the following results were obtained: 1) In rabbitts with injured liver serum cholinesterase activity reached its maximum 24 hours after the 3rd CCl(4) injection and returned to the original level, showing the improvement in the function of bromsulfalein excretion. 2) In the group with parathion injection 3 mg/kg each, serum cholinesterase activity was inhibited to the highest degree 3-6 hours after the parathion injection as in the healthy rabbits, but the slackening of cholinesterase activity in the injured was less marked than in the healthy, and lasted longer. 3) The LD(50) in the rabbits with injured liver was 3.88 (2.645.70) mg/kg, while the LD(50) in the healthy rabbits is 10 mg/kg. 4) In the injured rabbits parathion had no influence upon the recovery of the function of bromsulfalein excretion. en-copyright= kn-copyright= en-aut-name=TanimotoHajime en-aut-sei=Tanimoto en-aut-mei=Hajime kn-aut-name=谷本一 kn-aut-sei=谷本 kn-aut-mei=一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1899 end-page=1908 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Parathion Poisoning Part 1. Histological Changes in Various Organs of Labaratory Rabbits with Parathion Poisonig kn-title=パラチオン中毒に関する研究 第1編 パラチオン中毒家兎諸臓器の組織像 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Histolgical changes in rabbits with acute and chronic parathion intoxication have been examined, and the results are as follows: 1) In the rabbit with chronic parathion poisoning induced by repeated parathion injections, histological changes were the most remarkable in the central nervous system, and in lethal cases were of circulatory disturbances such edema, hyperemia and bleeding. 2) On the contrary, in the moderate cases with acute poisonig, the changes were not so remarkable, and a month later almost no change was observed. 3) Such changes above menthioned might be caused by circulatory disturbances due to the anticholinergic action of parathion, and again the direct action of parathion for such changes should perhaps not be neglected. en-copyright= kn-copyright= en-aut-name=TanimotoHajime en-aut-sei=Tanimoto en-aut-mei=Hajime kn-aut-name=谷本一 kn-aut-sei=谷本 kn-aut-mei=一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1869 end-page=1888 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Polysaccharides Extracted from the Bone Marrow on the Circulatory System Part III Action of the Polysaccharides Extracted from the Bone Marrow on the Blood Pressures as well as Side-Effects when used in Human Beings kn-title=骨髄抽出多糖類物質の循環器系統に及ぼす影響 第3編 骨髄抽出多糖類物質の血圧に対する作用並びに人体使用時の副作用に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied the action of the polysaccharides extracted from the bone marrow on the blood pressures as well as the side-effects when administered intravenously in human body; and obtained the following results: 1) These polysaccharides exert no influence on the arterial blood pressure of normal dogs, nor do they show tachyphylaxis. 2) These substances exert no influence whatsoever on the venous blood pressure in normal dogs. 3) These substances likewise in no way affect the blood pressures in human beings. 4) As regards the side-effects when administered intravenously in human body, in the majority of cases there appear a transitory flushing of the face, clizzness, and tachycardia, and occasionally a slight sweating, thirst. sleepiness, rash and fever, but they are in no way to be of a serious nature, as these side effects will gradually disappear with repeated uses of them. 5) It seems that the general conditions of an individual have nothing to do with the occurrence and severity of these side effects but have a great deal to do with individual susceptibility. en-copyright= kn-copyright= en-aut-name=TominagaHiromu en-aut-sei=Tominaga en-aut-mei=Hiromu kn-aut-name=富永弘 kn-aut-sei=富永 kn-aut-mei=弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1853 end-page=1868 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Polysaccharides Extracted from the Bone Marrow on the Circulatory System Part II The Action of Polysaccharides Extracted from the Bone Marrow on the Peropheral Blood Vessels kn-title=骨髄抽出多糖類物質の循環器系統に及ぼす影響 第2編 骨髄抽出多糖類物質の末梢血管に対する作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to elucidate still further the essential mechanism of the hematopoietic actions of polysaccharides extracted from the bone marrow, by Krawkow-Pissemiski's method the author studies the actions of these substances on the blood vessels of the ear lobes cut off from adult rabbits, and obtained the following results: 1) The polysaccharides extracted from the bone marrow act slightly dilatatively on the peripheral blood vessels of adult rabbits. 2) These substances seem to act antagonistically against the contracting actions of adrenalin and acetylcholine. 3) These substances seem to act cooperatively or as invigoratingly in conjunction with dilatative actions of atropine. 4) Ergotamine exerts almost no influence on the action of these substances. 5) These substances act strikingly antagonistically on the contraction by a blood vessel poison, barium chloride. From theses results it is construed that the mechanism of dilatation of blood vessels by these substances is the action to the vascular muscles, and that it possesses a parasympathetic nerve action on the vasomator and in addition, sympathetic nerve action though slight. en-copyright= kn-copyright= en-aut-name=TominagaHiromu en-aut-sei=Tominaga en-aut-mei=Hiromu kn-aut-name=富永弘 kn-aut-sei=富永 kn-aut-mei=弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1813 end-page=1825 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Sideroblasts Part 3 The Iron Metabolism of Erythroblasts kn-title=Sideroblastに関する研究 第三編 赤芽球と鉄代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By creating various changes mainly in erythroblasts of adult rabbits and by administering iron to these animals, changes in the proportion of sideroblasts have been studied comparatively; and the iron intake by erythroblasts has been examined. The following are the results of the study: 1) There seems to be a limitation in the iron intake by erythroblasts, namely, the iron intake is not solely dependent on the quantity of iron supplied by serum, but also it is influenced greatly by the quantity of nonhemoglobin iron controlled by the amounts of hemoglobin in the erythroblasts matured to a certain stage. 2) It is believed that the mechanism of iron intake is of a relatively simple nature something like diffusion, i.e., the degrees of concentration of the amounts of iron supplied by serum on one side and nonhemoglobin iron in erythroblasts on the other side, of the cellwall. 3) In erythroblasts, three steps of the metabolic process, namely, intake, retention and utilization of iron, essentially take place almost simultaneously, mainly in the later maturation phase. en-copyright= kn-copyright= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1799 end-page=1812 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Sideroblasts Part 2 Sideroblasts and Bone Marrow Functions (Experimental Anemias) kn-title=Sideroblastに関する研究 第二編 骨髄機能（実験的貧血）とSideroblast en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various experimental anemias have been induced in adult rabbits mainly centering around the hematopoietic functions of the bone marrow; and with continuous observations on the changes of sideroblasts, a series of comparative studies between the sideroblasts and serum iron has been carried out; and obtained the follwing results: 1) The proportion of sideroblasts in normal rabbits is lower and the extent of the sideroblast appearance less extensive than that in the normal persons. 2) The proportion of sideroblasts increases in such anemias where there is a decline in the erythropoietic function as in benzol, collargol, x-irradiation anemia, whereas it returns to normal level at the time when the benzol anemia is recovering. 3) The proportion of sideroblasts either decreases or becomes nil in acute and chronic hemorrhagic anemias where there exist an increase in the erythropoietic function and iron deficiency. 4) In the case which is in the process of hemolysis such as in the phenylhydrazine anemia, the proportion varies according to the period; and it shows no marked change at the extreme periods while it increases at the time of recovery. Furthermore, no significant change can be observed in the saponin anemia. 5) Parallel relationship between sideroblasts and serum iron is not always clearly noticeable, but the two seem to be always in the state labile to utilization. Again, this stainable iron in erythroblasts is understood to be directed solely for utilization and is by far the most labile to iron utilization. 6) From these observations, it may be said that the changes of sideroblasts or of this stainable iron, are dependent upon the conditions of equilibrium existing between the iron supply by serum iron and the utilization of iron controlled by hematopoietic functions. en-copyright= kn-copyright= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1773 end-page=1798 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Sideroblasts Part 1 Sideroblasts in Blood Disorders kn-title=Sideroblastに関する研究 第一編 血液疾患とSideroblast en-subtitle= kn-subtitle= en-abstract= kn-abstract=By examining sideroblasts in normal subjects and in patients with various hematologic disorders and determining the rates of appearance, a sideroblastogram consisted of classifications of types I, II and III, according to numbers of iron granules was made. Again, sideroblast ratios (S. r.) were computed and studies were carried out by comparing the proportion of sideroblasts with serum iron. The results are as follows: 1) The proportion of sideroblasts has been found extensively in the normal persons, but in the sideroblastogram it is all intermediary in type, whose sideroblast ratio never exceeds 1 nor yields zero. 2) The proportion of sideroblasts in the cases of erythropoietic disturbances in the bone marrow such as hypoplastic anemia, leukemia, disorders due to irradiation has been found generally high, and in almost all these cases the proportion of sideroblasts reveals a shift to the right in the sideroblastogram at the same time S. r. has been above 1. 3) In various iron deficiency anemias in a broader sense, the proportion of sideroblasts is decreased and a shift to the left is demonstrated in the sideroblastogram; and S. r. is zero or is approaching to zero. 4) On the other hand, in Graves' disease and kala-azar the proportion of sideroblasts is normal, but in hemolytic anemia, liver cirrhosis and chronic nephritis it is high. Again, in agranulocytosis and myxedema the proportion of sideroblasts is low. 5) Sideroblasts seem to have some relationship with serum iron, but the two do not necessarily change parallel with each other. 6) These procedures of the determining of sideroblasts are equally useful or even superior to similar methods on serum iron in the differentiation of various anemic patients. 7) From these results, it is believed that stainable iron in these sideroblasts exists between serum iron and hematopoiesis in the process of utilization, and that it naturally has a close association with both serum iron and hematopoiesis. Note: Sideroblasts are the erythroblasts containing stainable, nonhemoglobin iron granules. en-copyright= kn-copyright= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1735 end-page=1744 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Blood Vessels of Tuberculous Cavities Part Three Effects of Streptomycin (SM), and Isonicotinic Acid Hyrazide (INAH) on the Blood Vessels of the Cavity-Wall kn-title=肺結核空洞の血管構造に関する研究 第三編 肺結核空洞の血管構造及び空洞壁血管に対するStreptomycin, Isonicotinic Acid Hydrazideの影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=With administration of 20 mg./k. of SM (streptomycin) per day to 8 cavities induced experimentally in the lungs of adult rabbits, and 10 mg./k. of INAH (isonicotinic acid hydrazide) to 5 cavities similarly induced, continuously for 30 days, the author has obtained Spalteholz's preparates after injection of pigment into the lungs and patho-histological specimens as well and after studying these specimens, he has arrived at the following conclusions: 1) The vascularization of the cavity walls receiving either SM treatment or INAH therapy, has been similar to that of the control group as previously mentioned in Part One. 2) In the SM treatment, the new formation of blood vessels and hyperemia in granulation tissues of the cavity-wall show no especial difference as compared with those of the control group. 3) In the INAH treatment, marked hyperemia of capillaries and new formation of blood vessels, and in places, hemorrhage in granulation tissues of the cavity-wall have been observed. en-copyright= kn-copyright= en-aut-name=TakataJunnosuke en-aut-sei=Takata en-aut-mei=Junnosuke kn-aut-name=高田潤之介 kn-aut-sei=高田 kn-aut-mei=潤之介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1711 end-page=1724 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Blood Vessels of Tuberculous Cavities Part One On the Blood Vessels and Vascularization of Tuberculous Lesions Mainly on the Pulmonary Cavities kn-title=肺結核空洞の血管構造に関する研究 第一編 空洞を中心とする肺結核病巣の血管並びに血管構造について en-subtitle= kn-subtitle= en-abstract= kn-abstract=By making Spalteholz's preparates from the lungs of adult rabbits, mainly from the 18 experimentally induced cavities and 11 caseous foci, following the progress of these tuberculons lesions, and examining these specimens under a 3-dimentional microscope, the author has arrived at the following conclusions: 1) In the tuberculous lesions, it has been found that the blocking of the pulmonary artery occurs and subsequent blocking of pulmonary veins. 2) In the caseous foci, blood vessels are almost obliterated and occasionally newly formed blood vessels are seen around the main artery and vein as well as around their residual branches. 3) On the capsules of the caseous foci are found comparatively less vessel distribution as compared with those on the cavity walls, while stenosis and dilatation can be recognized around the branches of arterioles and venules. 4) In the periphery of caseous foci, bronchial arteries have become dilated and among the bronchial arteries and bronchial wall vessels are found newly formed arterioles and venules. 5) Around the caseous foci are found occasional anastomoses precapillary and capillary between the newly formed pulmonary and bronchial arterioles, but numbers of these anastomoses are less than the numbers of cavity-walls. 6) Blood in the bronchial artery is seen flowing even into the pulmonary artery by way of the anastomoses around the caseous foci, previously mentioned. Consequently the caseous foci are supplied with arterial blood by the bronchial arteries as well as by newly formed pulmonary arterioles. 7) In the caseous foci that have started cavitation, newly formed bronchial arterioles can be recognized on the cavity walls at the orifice of drainage bronchus. 8) Pulmonary arteries and veins distributed in the cavity are blocked before reaching the cavity; but when they remain in the cavity in the form of beam, residual vessel lumen are seen in the central part of the beam and newly formed blood vessels of networks are seen surrounding the beam. 9) When the main pulmonary artery and vein are running on the side-wall of the cavity, these vessels are compressed, narrowed, and dislocated; and aneurysm and varix-like dilatation can occasionally be recognized. 10) Capillaries distributed on the cavity wall are classified into three categories according to their origin, namely, (1) those capillary vessel-networks that are newly formed from the small branches of pulmonary artery or vein; (2) those capillary vessel networks that communicate at the main trunk of pulmonary artery or vein; (3) those capillary vessel networks that are located at the orifice of the drainage bronchus and communicate at bronchial artery. 11) Vessels on the cavity wall mentioned above make small circles immediately under the necrotic layer, and reverse to venulous vessels. All these capillaries are closely connected with each other in a network formation. 12) The bronchial arteries distributed on the cavity walls are dilated and turned and twisted. thus the bloodflow is thought to have increased; and on the side of the hilus pulmonis of the cavity, numerous precapillary or capillary anastomoses are seeu between pulmonary and bronchial artery around the drainage bronchus. 13) The degree of changes in bronchial vein is less than that observed in the brohial artery, but the vessels on the bronchial wall are proliferated. 14) New vessels are formed from pulmonary arterioles and venules in the sickened portion of caseous foci and cavities; and the intercostal, the csophageal, and the pericardiac arteries penetrate into these pleuritic regions and anastomosed with each other. en-copyright= kn-copyright= en-aut-name=TakataJunnosuke en-aut-sei=Takata en-aut-mei=Junnosuke kn-aut-name=高田潤之介 kn-aut-sei=高田 kn-aut-mei=潤之介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1699 end-page=1710 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Protein Metabolism of the Explanted Bone Marrow Culture in Rabbits Part Three Influences of Sera from various Patients on the Protein Metabolism in the Rabbit Bone Marrow kn-title=家兎骨髓体外組織培養に於ける蛋白代謝の研究 第3編 各種疾患患者血清の家兎骨髄蛋白代謝に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By loading the tissue culture (Carrel flask method) of the bone marrow of normal rabbits with sera of Patients suffering from various diseases, various factors involved in multiplication of the bone marrow at the same time the influences of these of these sera on the protein metabolism in the rabbit bone marrow have been investigated and the following are the results: (1) Sera of hypolastic anemia, Banti's disease, and of leukemia act directly on the bone marrow, and the presence of the substances inhibiting the marrow functions has been recognized, inhibiting the production of γ-globulin and fibrinogen by the marrow. (2) No substance acting directly on the bone marrow has been recognized in the sera of such blood disorders as essential hypochromic anemia, hookworm disease, Werlhof's disease, as well as in liver and kidney diseases or tuberculosis, and the loading of such sera to the marrow culture exerts no influence on the protein metabolism. (3) In the serum of cancer patient, the presence of substance slightly inhibiting the marrow functions has been recognized. en-copyright= kn-copyright= en-aut-name=FujiiYukio en-aut-sei=Fujii en-aut-mei=Yukio kn-aut-name=藤井幸雄 kn-aut-sei=藤井 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1685 end-page=1698 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Protein Metabolism of the Explanted Bone Marrow Culture in Rabbits Part Two The Protein Metabolism of the Bone Marrow in Experimental Anemic Rabbits kn-title=家兎骨髓体外組織培養に於ける蛋白代謝の研究 第2編 実験的貧血家兎骨髄の蛋白代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The protein metabolism of the bone marrow in experimental anemic rabbits had been studied with explanted bone marrow culture (Carrel flask method) and the following results were obtained: (1) The consumption of albumin and the production of globulin and fibrinogen, have been found to have rather decreased in the bone marrow of the rabbits given benzol for a short period of time. Next, in the case of the rabbits given benzol for a longer period of time. hypolasia of the bone marrow has been quite marked, namely, the consumption of albumin is low and production of globulin or of fibrinogen can hardly be noticed. (2) In the rabbits given saponin, the findings have been almost identical with those of the normal. (3) In the rabbits administered with phenylhydrazin or collargol, the marrow functions are low, the consumption of albumin slack, and the production of globulin and fibrinogen has been markedly low. (4) In the rabbits irradiated by x-rays, the marrow function have been completely deteriorated; namely, neither the consumption of albumin nor the production of globulin and fibrinogen can at all been seen. en-copyright= kn-copyright= en-aut-name=FujiiYukio en-aut-sei=Fujii en-aut-mei=Yukio kn-aut-name=藤井幸雄 kn-aut-sei=藤井 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=7 article-no= start-page=1669 end-page=1684 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Protein Metabolism of the Explanted Bone Marrow Culture in Rabbits Part One Protein Metabolism of the Rabbit Bone Marrow, and Effects of Various Drugs on it kn-title=家兎骨髓体外組織培養に於ける蛋白代謝の研究 第1編 正常家兎骨髄蛋白代謝並びに該代謝に及ぼす各種薬物の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By carrying out a series of observations on the protein metabolism by bone marrow culture (Carrel flask method) and on the effect of various drugs acting directly on the bone marrow, the following results have been obtained: (1) Albumin is utilized for multiplication of the bone marrow tissue while globulin is produced by the bone marrow. Consequently, the increase of globulin has a correlation with marrow functions in direct proportion. (2) In globulin fractions, γ-globulin seems to play the most important rôle. (3) Both α- and β-globulins seem to play no important rôle. (4) Fibrinogen is produced by the bone marrow, and it has a close relationship with marrow functions. (5) Folic acid, vitamin B12, and bone marrow extract directly stimulate marrow functions, and they promote the production of globulin, especially of γ-globulin and fibrinogen on one hand, and the consumption of albumin on the other hand. (6) Nitromin (Nitrogen mustard-N-oxyde) lowers functions of the bone marrow and inhibits the production of globulin, paricularly γ-globulin and fibrinogen, and the consumption of albumin. en-copyright= kn-copyright= en-aut-name=FujiiYukio en-aut-sei=Fujii en-aut-mei=Yukio kn-aut-name=藤井幸雄 kn-aut-sei=藤井 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=6 article-no= start-page=1635 end-page=1651 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Oxygen Consumption and Glycolysis of Bone Marrow Tissue Part IV On the O(2)-Consumption and Glycolytic Metabolism of Essential Chloranemias Bone Marrow kn-title=骨髓の組織呼吸並に解糖作用に関する研究 第4編 本態性萎黄貧血骨髄の呼吸解糖代謝に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=At first with sternum-puncture of the patients suffering from essential chloranemias (idiophathic hypochlomic anemia), the observations on the bone-marrow picture and the determinations of the O(2)-consumption and glycolysis had been conducted; and then, after adding the serum of the patient to the bone marrow of normal rabbit, in vitro, again the rates of the O(2)-consumption as well as of glycolysis of the bone marrow of the rabbits receiving continuously for one week injections of the same serum were determined. With these results and with comparative studies on the case of bleeding anemia with that of hook-worm anemia, the author have drawn the following conclusions: 1. The number of nucleated cells in the punctuate of the essential-chlorosis patient as well as the percentage of the erythroblasts in the bone-marrow picture increased; and the majority of the latter were basophilic; and furthermore, of those that were neutrophilic, promyelocytes and or metamyelocytes showed a slight increase in number while mature cells revealed a decrease. 2. The O(2)-consumption and glucolysis of the punctuate drawn from the patient showed an increase in the rate, the latter especially markedly; whereas the fat-free dry weight of the punctuate had been light but after the treatment it showed a tendency to return to normal. 3. On comapring the O(2) consumption and glycolysis of the bone marrow of the rabbits receiving continuous injections of the patient's serum with those of the bone marrow of the rabbits injected with the serum of the normal, no marked difference whatever could be recognized. 4. Similar comparative observations made with regard to the effects on the O(2)-consumption both in the case where the patient's serum had been added to the normal rabbit bone-marrow and where the normal person's serum to the rabbit's bone marrow, revealed no substantial difference. 5. A marked rise of the rates of both the O(2)-consumption and glycolysis of the punctuate from the patient is in a strange contrast to the case of hemorrhagic anemia where there is no change at all; and furthermore, the rise has a certain similarity to the rising picture of hookworm anemia but the degree of the rise in the case of this desease is far greater than that of the latter. en-copyright= kn-copyright= en-aut-name=IshibashiTadao en-aut-sei=Ishibashi en-aut-mei=Tadao kn-aut-name=石橋忠男 kn-aut-sei=石橋 kn-aut-mei=忠男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=6 article-no= start-page=1619 end-page=1634 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Oxygen Consumption and Glycolysis of Bone Marrow Tissue Part III On the O(2)-Consumption and Glycolysis of the Bone Marrow of the Hook-Worm Anemia and the Effects of the Serum of the Same Anemics on the O(2)-consumption of the Bone Marrow kn-title=骨髓の組織呼吸並に解糖作用に関する研究 第3編 鉤虫性貧血骨髄の呼吸解糖作用並に同血清が正常家兎骨髄酸素消費に及ぼす影響に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=Investigating the bone-marrow pictures and the O(2)-consumption as well as the glycolysis in the bone marrow both of the hook-worm anemics and of the hook-worm dogs, the author, in comparison with those of the bleeding anemia reported in Part II, arrived at the following conclusions: 1. On puncturing the sternum of hook-worm anemics, a picture of maturity arrest was revealed in their bone-marrow picture. On the other hand, in the bone marrow of hook-worm dogs (oral infection with 500 larvae), a bleeding-anemia picture had been revealed at the early stage of anemia, but along with the aggravation of the disease, a picture of maturity arrest was recognized. 2. The slight increase of the O(2)-consumption and an increase of the anaerobic glycolysis were observed in the punctuate of the hook-worm anemics. 3. In the bone marrow of dogs orally infected with 1, 000 larvae, the rate of the O(2)-consumption had increased at the early stage while it decreased along with the aggravation of anemia. 4. In the bone marrow of the dogs receiving 500 oral larvae, the rate of the O(2)-consumption also increases at the early stage, and though lowering gradually along with the aggravation of the disease, it never goes below the normal rate. Whereas the rate of anaerobic glycolysis has been seen to rise by degrees in proportion to the degree of anemia. 5. On comparative observations, the effects on the O(2)-consumption of the normal-rabbit bone marrow injected with the serum of the hook-worm anemics differ not in any great extent from those of the normal-rabbit bone marrow injected with the serum of normal person. 6. The oxygen consumption and glycolysis of the bone marrow of the hook-worm anemia differ from those of the hemorrhagic anemia; and of the causative factors of this disease, not only the hemorrhagic factor but also the toxic factor seem to play very important roles. en-copyright= kn-copyright= en-aut-name=IshibashiTadao en-aut-sei=Ishibashi en-aut-mei=Tadao kn-aut-name=石橋忠男 kn-aut-sei=石橋 kn-aut-mei=忠男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=6 article-no= start-page=1605 end-page=1618 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Oxygen Consumption and Glycolysis of Bone Marrow Tissue Part II On the O(2)-Consumption and Glycolysis in the Bone Marrow of Anemic Rabbits Experimentally Depleted, and the Effects of the Sera of these same Experimental Rabbits on the O kn-title=骨髓の組織呼吸並に解糖作用に関する研究 第2編 実験的瀉血貧血家兎骨髄に於ける呼吸解糖作用並に同血清が正常家兎骨髄酸素消費に及ぼす影響に就て第2編 実験的瀉血貧血家兎骨髄に於ける呼吸解糖作用並に同血清が正常家兎骨髄酸素消費に及ぼす影響に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=By determining periodically the O(2)-consumption and the anaerobic glycolysis in the bone marrow of the rabbits depleted successively 4 times the rate of 10 c.c. /kg., with the slicing and the homogenate methods mentioned in the previous report, and by tracing the effects of the sera of these depleted rabbits on the O(2)-consumption in the bone marrow of normal rabbits, the authors have obtained the following results: 1. As regards the rate of O2-consumption in the case where the slicing method had been used or that in the homogenate method, the rates in both cases tended to increase 24 hours after a single depletion, and it later showed a continuous rise. Whereas in those rabbits subjected to four successive depletions, the O(2)-consumption reached the highest point 24 hours afterwards, and on cessation of depletion and following the gradual recovery of anemia, the O(2)-consumption decreased concomitantly; and 9 days after the cessation of depletion the rate returned more or less to normal. 2. The rate of O(2)-consumption paralleled with the percentage of immature cells of the erythroblastic system as well as of erythroblasts in the bone marrow and with the increase of mitotic figures. 3. A slight increase of the anaerobic glycolysis Q(M)(N(2)) could be observed only during the depleting periods in the case where either of the two methods had been employed; and the periodic fluctuations of Q(M)(N(2)) tended to be similar to those of the O(2)-consumption. The rate, however, returned to normal 3 days after the cessation of depletion; and later lowering slightly, it finally returned to normal. 4. A parallel relationship existed between the lowering of respiratory and glycolytic ration (Q(M)(N(2))/Q(O(2))) and the percentage of the myeloid cells in the bone marrow. 5. Some substances promoting the O(2)-consumption of the bone marrow of normal rabbits were found to exist in the serum of the depleted rabbits previously mentioned; and the time of the appearance or the disappearance of these substances as well as their effects seemed to coincide with the amounts of O(2)-consumption of the bone marrow itself. 6. These substances found in the above-mentioned serum were found to be so heatresistant that they could not be destroyed even when heated at the temperature of 100°C for 30 minutes. en-copyright= kn-copyright= en-aut-name=IshibashiTadao en-aut-sei=Ishibashi en-aut-mei=Tadao kn-aut-name=石橋忠男 kn-aut-sei=石橋 kn-aut-mei=忠男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=6 article-no= start-page=1591 end-page=1604 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Oxygen Consumption and Glycolysis of Bone Marrow Tissue Part I Methods of the Determination of Oxygen Consumption and Glycolysis in the Bone Marrow of Normal Rabbits kn-title=骨髓の組織呼吸並に解糖作用に関する研究 第1編 正常家兎骨髄の呼吸解糖作用測定方法に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Relative to the determination of O(2)-consumption and glycolysis with the use of Warburg's apparatus, as one of the methods in tracing bone marrow functions, the authors have carried out comparative studies on the following three methods by using the same normal domestic rabbits. METHODS 1. Slicing method is a method in which two Graefe's knife are used as to obtain the slices of bone marrow in the thickness, the socalled limit slice. 2. Homogenate method is a method in which the precipitate of bone marrow is obtained after homogenization and centrifugation. 3. Boring method is a method in which punctuate is obtained from a given portion of the tibia by aspirating it as rapidly as possible at the pressure of -10 mg. Hg. RESULTS 1. The bone marrow pictures observed both in the slicing and in the homogenate methods presented rather similar findings, while in the case of the boring method it revealed the increases of the pseudo-eosinophiles, the mononuclear, and the polymorphonuclear leucocytes as well as a marked proliferation of lymphocytes, mixed with some peripheral blood. 2. The impairment of cells has been found least in the case of the slicing, followed by tho homogenate method, and the geatest in the boring. The boring method, however, has advantages of making over-all course observations of the same individual possible and it is simpler to manipulate, but it also has disadvantages of giving lower values of O(2)-consumption and glycolysis, and a greater error in the evaluation. As for the determination of O(2)-consumption values in the slicing method, the values yielded are highest and the lowering rate of value during the observation period is least. For the determination of anaerobic glycolysis, the values obtained by the homogenate method have been found to be highest; while in the case of the slicing method, more constant values with respect to the elapse of time during observation has been obtainable. From these results I have reached a conclusion that the slicing method is the best of the three methods for the determination of O(2)-consumption and glycolysis in the rabbit bone marrow. en-copyright= kn-copyright= en-aut-name=IshibashiTadao en-aut-sei=Ishibashi en-aut-mei=Tadao kn-aut-name=石橋忠男 kn-aut-sei=石橋 kn-aut-mei=忠男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=6 article-no= start-page=1579 end-page=1590 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Pathologic Physiology of the Bone Marrow Part Three Permeability Inhibition to Dyes in Various Sinuses of the Bone Marrow of the Rabbits Blocked of the Reticulo-Endothelial System by Indian Ink kn-title=骨髓の病態生理に関する研究 第三編 網内系墨汁填塞家兎骨髄静脈竇に於ける色素透過阻止について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fujii, Fujita, and Soejima of our laboratory, after a series of experiments with adult rabbits, have already made it clear that retension or mobilization of the marrow blood by the marrow circulation of active substances in the marrow is controlled by contraction or dilatation of the marrow blood vessels, namely, by the vascular actions: and they further have mentioned that no such retension or mobilization is observable in the rabbits blocked of the reticul-endothelial system by indian ink. Therefore, in order to investigate by what mechanism the blocking of the reticulo-endothelial system inhibits vascular actions, the author has performed the following experiment. Namely, by pouring 1% Patent blue, Tripan blue, or Berlin blue dissolved in saline in intact adult rabbits and in the rabbits blocked of the reticulo-endothelial system by indial ink. Splteholz's preparates and tissue specimens of the femur have been made, and the permeability through blood vessels of the dyes mentioned above has been observed: and the following interesting results have been obtained: 1) Any one of these dyes can readily pemeate from venous sinuses of the bone marrow if intact rabbits while none permeates in the case of the rabbits blocked of the reticulo-endothelial system by indian ink. 2) From the above fact, it seems that all the active substances of the bone marrow permeate through venous sinusess into the marrow parenchyma on which they act, at the sametime exerting influences on the marrow nerves; while in the cases whose reticuloendothelial system is blocked by indian ink, that is, when the walls of venous sinus are blocked with indian ink, the permeability of such active substances is inhibited and consequently no action takes place. en-copyright= kn-copyright= en-aut-name=SatoHyoye en-aut-sei=Sato en-aut-mei=Hyoye kn-aut-name=佐藤兵衛 kn-aut-sei=佐藤 kn-aut-mei=兵衛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=6 article-no= start-page=1567 end-page=1577 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Pathologic Physiology of the Bone Marrow Part Two A Study on the Bone Marrow and Blood Volume in the Spleen of Normal Rabbit, as well as the Blood Circulation of the Bone Marrow in Various Experimental Anemic Rabbits' with I(131) kn-title=骨髓の病態生理に関する研究 第二編 I(131)による正常家兎骨髄及び脾の血液量並に各種実験的貧血家兎骨髄の血行状態に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Today anatomical studies on the bone marrow, particularly on features of vascular construction are almost completely known, and no one can refute that more than a half of the bone marrow is composed of blood vessels, thus naturally the space occupied by the vessels is quite extensive. In view of this, with the use of an isotope I(131) as a tracer, the author has estimated in figures the volume of blood in the bone marrow of adult rabbits as well as that of the spleen whose vascular construction is similar to that of the bone marrow at the same time measured in the same manner the volume of blood in the bone marrow and the spleen of various experimental anemic rabbits. After comparing the results of those two groups, the following data have been obtained: 1) On the average, 0.5 c. c. of blood is contained in 1 g. of the bone marrow of the normal rabbit, the average of 0.44 c. c. in the spleen, and in 1 g. of muscle 0.07 c. c. of blood is containd on the average, thus it is clear that both the bone marrow and spleen are the organs rich in blood. Especially the voluminousness of the blood vessels in the bone marrow has been proven in figures from the peculiar vascular construction itself which enables an anatomical estimation. 2) The amounts of blood in the bone marrow and spleen decrease accompanying the decrease in the amount of blood in the circulation by bleeding, and following the recovery of the amount of circulating blood the recovery in the spleen is faster than that in the bone marrow. This due to the fact that the spleen is more elastic of the two organs. 3) As regards various experimental anemic rabbits, especially in those caused by leucocyte toxins (x-ray irradiation, injection of nitrogen mustard, or administration of benzol), the amount of blood in the bone marrow has been found to have decreased in the bone marrow whereas in the spleen it has been found to have increased. This phenomenon can be explained by the fact that in the bone marrow it is caused by disturbances of blood circulation while in the spleen by hyperemia. Again in the case of injection of phenylhydrazin which is considered to be especially toxic to erythrocytes, the amounts of blood both in the bone marrow und spleen do decrease but this is so because in this case the blood circulation is disturbed in both organs. en-copyright= kn-copyright= en-aut-name=SatoHyoye en-aut-sei=Sato en-aut-mei=Hyoye kn-aut-name=佐藤兵衛 kn-aut-sei=佐藤 kn-aut-mei=兵衛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=6 article-no= start-page=1551 end-page=1565 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Pathologic Physiology of the Bone Marrow Part One A Supplementary Study on the Behaviors of the Bone Marrow in a Rapid Bleeding kn-title=骨髓の病態生理に関する研究 第一編 急性出血に於ける骨髄の態度に関する研究補遺 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Previously in our laboratory Tachibana has proven that the bone marrow like other blood-storage organs discharges a great quantity of blood in acute bleeding and that it also occupies an important position among the blood-storage organs. In order to endorse Tachibana's results still further the author has investigated the changes in the erythrocyte counts, hematocrit values, average diameter of erythrocytes, Price-Jones curve, average volume of erythrocytes. and volume index in the nutrient veins of the femur as well as the findings on the bone marrow of adult rabbits after a rapid depletion of blood in the same manner as Tachibana, and the results of the observations are as follows: 1) When a rapid depletion of blood to the amount of 15-20 c. c. /K. is performed in rabbits, an increase of erythrocyte count as well as increase in the hematocrit value can be observed in the nutrient venous blood of the femur, and these increases are especially marked 1-2 hours after depletion. However, through entire course no striking change can be recognized in the Price-Jones curves, averages of the diameter, the volume, and the volume index of erythrocytes; and from these data the increases in erythrocytes and in the hematocrit value are thought to be due to the mobilization of the blood stored in the bone marrow venous sinuses. 2) In the findings of the bone marrow tissues in the rabbit rapidly depleted of blood the decrease of blood in venous sinus is most marked or totally disappeared 1-3 hours after depletion while it later recovers gradually until finally it presents a blood repletion picture somewhat similar to that of the normal. In other words, the blood in the veins of the bone marrow is rapidly mobilized to the outside of the marrow after depletion, and later new blood corpuscles from the hematopoietic foci are recognized to be transferred and stored in the venous sinuses. 3) These results clearly support the experimental results of Tachibana of our labor atory: and therefore, it is thought that the bone marrow, being a blood-storage organ, has an important significance in the repletion of blood in general circulation. en-copyright= kn-copyright= en-aut-name=SatoHyoye en-aut-sei=Sato en-aut-mei=Hyoye kn-aut-name=佐藤兵衛 kn-aut-sei=佐藤 kn-aut-mei=兵衛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=947 end-page=958 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and Clinical Studies on Parathionpoisoning Part 3. The Effectiveness of SH Medical Compounds and PAM on Parathion Poisoning - especially on Protein Active SH Radical and Mucoprotein of Serum - kn-title=パラチオン中毒に関する実験的並びに臨床的研究 第三編 パラチオン中毒治療剤と血清蛋白活性SH基及びムコ蛋白 en-subtitle= kn-subtitle= en-abstract= kn-abstract=SH medical compounds used in this study were BAL, sodium thiosulfate, cystine, menthionine and sodium mercaptoacetate. 1. In the animal tests on the effectiveness of SH medical compounds, BAL was the most effective and then sodium thiosulfate was next, while scarecely effect was observed in the experiments of cystine, methionine and sodium mercaptoacetate. 2. By the administration of PAM, SH enzyme such as mucoprotein was promptly and certainly reactivated as well as cholinesterase. en-copyright= kn-copyright= en-aut-name=HukuharaArimitsu en-aut-sei=Hukuhara en-aut-mei=Arimitsu kn-aut-name=福原有光 kn-aut-sei=福原 kn-aut-mei=有光 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=935 end-page=943 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and Clinical Studies on Parathionpoisoning Part 2. Mucoprotein in the Cases of Parathion Poisoning kn-title=パラチオン中毒に関する実験的並びに臨床的研究 第二編 パラチオン中毒のムコ蛋白に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Mucoprotein of sera and organs was examined in rabbits and patients with parathion poisoning to clarify the mechanism of poisoning and the advanced information was acquired as follows. 1. Serum mucoprotein was considerably inhibited in parathion poisoning and its inhibition correlated with the degrees of parathion poisoning as the cases of serum cholinesterase and protein active SH radical. Moreover, its recovery was quicker than that of serum cholinesterase and protein active SH radical. 2. Mucoprotein was, in the rabbits subcutaneously injected with 5 mg/kg of parathion, inhibited considerably in all organs, especially in the liver and then followed by the kidney, brain, spinal cord, spleen, intestine, stomach, muscle, lung, and heart, in the order mentioned. But in the case of kidney, both the inhibition and recovery of mucoprotein were delayed markedly. In the fatal cases with the subcutaneous injection of 100 mg/kg parathion, mucoprotein decreased considerably in all organs, especially in the case of the liver where it decreased to 13.8 per cent. From the above-mentioned, parathion absorbed into a living body, combine with SH radical, especially of lower molecule such as mucoprotein mainly fixed in liver, brain, spinal cord etc. These SH radical consumption was supposed to be a cause of the inhibition of cholinesterase activity. en-copyright= kn-copyright= en-aut-name=HukuharaArimitsu en-aut-sei=Hukuhara en-aut-mei=Arimitsu kn-aut-name=福原有光 kn-aut-sei=福原 kn-aut-mei=有光 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=925 end-page=933 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and Clinical Studies on Parathionpoisoning Part 1. Protein Active SH Radical in the Case of Parathion Poisoning kn-title=パラチオン中毒に関する実験的並びに臨床的研究 第一編 パラチオン中毒の蛋白活性SH基に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Protein active SH radical of sera and orgaus was examined in rabbits and patients with parathion poisoning. Advanced informations in this experiment were as follows. 1. In parathion poisoning, serum protein active SH radical was markedly inhibited. 2. Inhibition and recovery of serum protein SH radical correlated with that of serum cholineterase activity. 3. The decrease of serum protein active SH radical was relative to the symptoms of poisoning in their degrees, and it took about two weeks to restore in serious cases. 4. In rabbits subcutaneously injected with 5 mg/kg of parathion, protein active SH radical of organs was slightly inhibited only in the initial stage, thereafter reactive increase was observed. In the case of kidney, however, it decreased considerably and its recovery took much longer time in comparison with the others. In the fatal cases with the subcutaneous injection of 100 mg/kg parathion, the protein active SH radical of rabbit organs tended to increase generally. From the above-mentioned, parathion inhibited not only cholinesterase but also protein active SH radical of SH ferment as the cases of arsenic or heavy metal poisoning. en-copyright= kn-copyright= en-aut-name=HukuharaArimitsu en-aut-sei=Hukuhara en-aut-mei=Arimitsu kn-aut-name=福原有光 kn-aut-sei=福原 kn-aut-mei=有光 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=673 end-page=690 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on Heinz's Body Part Three: Observations on Heinz's Body in Experimental, Anemic Domestic Rabbits and the Application of Phase-Contrast Microscope on Heinz's Boby kn-title=ハインツ氏小体に関する研究 第三編 諸種実験的貧血家兎に於けるハインツ氏小体の観察及び位相差顕微鏡のハインツ氏小体への応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. In the case of acute, depleted domestic rabbits, Heinz's body appeared in an intermediate degree 12 hours after the depletion, while in the case of chromic, depleted rabbits a slight or an intermediate acceleration of the Heinz-body formation was noticed 24 hours after the depletion and there on. From this the penetrability through the wall of erythrocytes seems to have an important relationship with the formation of Heinz's body. 2. The formation of Heinz's body is quite high in the case of the rabbits inoculated with phenylhydrazin, thus the penetrability in this case also, raises a question. 3. In the rabbits injected with benzol, the formation of Heinz's body has been of a high degree, and their recovery necessitates an extremely long period of time. 4. In the case of those receiving saponin injection, a mild degree of the formation of Heinz's body started 8 days after the initial injection, but after the cessation of the injection the formation decreased rapidly along with the improvement of hematic picture; and four days after the cessation all returned to normal. 5. In the kollargol injection cases, an intermediate degree of the formation was noticed 8 to 12 days afterwards, and it was found that the reticulo-endothelial system has something to do with the elimination of Heinz's body. 6. With the use of a phase-contrast microscope, Heinz's body in the form of unstained specimens had been possible of observation in each contrast but reticulated erythrocytes could not be observed. This seems to be due to the fact that there is no difference at all in the phase-contrast between the reticulated substances of reticulated erythrocytes and the cytoplasmas of erythrocytes. en-copyright= kn-copyright= en-aut-name=SaitoTetsuro en-aut-sei=Saito en-aut-mei=Tetsuro kn-aut-name=斎藤哲郎 kn-aut-sei=斎藤 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=649 end-page=672 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on Heinz's Body Part two: Observations on Heinz's Body in Various Anemic Patients, in the Domestic Rabbits Injected with the Serum of Anemics, and in the Erythrocytes of Normal Person Treated with the Anemic Serum kn-title=ハインツ氏小体に関する研究 第二編 諸種血液疾患々者,患者血清注射家兎及び患者血清添加健康人赤血球に於けるハインツ氏小体の観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. Of 110 anemic patients observed in the determination of Heinz's body, the patients suffering from aplastic anemia gave the highest value and then those of leukemia, anchylostomiasis, Banti's syndrome, hemorrhagic anemia, essential chlorosis, aglanulocytosis, endocarditis lenta, and Welhoff's disease, in the order mentioned. 2. In the case of the domestic rabbits inoculated with sera of various anemics at the dose of 2cc/kg each, continuously for one week, the order of anemias, if arranged according to the rates of the Heinz-body appearance, will be aplastic anemia, leukemia, anchylostomiasis, Banti's syndrome, essential chlorosis, hemorrhagic anemia, and Welhoff's disease. From this result, practically no substance accelerating the formation of Heinz's body appears to be in the sera of hemorrhagic anemia and Welhoff's disease, while such substances may be thought to exist in the rest of anemic sera (although in the case of essential chlorosis, it is not definitely certain). 3. When the erythrocytes of normal person were left suspended in the sera of various anemics for 3 hours and these erythrocytes measured separately for Heinz's body, the order of diseases arranged according to the rates of the appearance of Heinz's body was more or less like as follows: aplastic anemia, leukemia, anchylostomiasis, Banti's syndrome, essential chlorosis, hemorrhagic anemia, and Welhoff's disease. 4. From these results, it is clear that whether the determination for Heinz's body be made with the blood directly tapped from the patient, or with the domestic rabbits receiving the anemic serum continuously for one week, or with the blood of normal person treated with an anemic serum, in vitro, any one of the three methods proves to be an invaluable aid in differentiation of the anemic patients and in determination of seriousness of the disease itself. Furthermore, it may be assumed that in the sera of the anemics, there exist some subclinic, intrinsic toxins which accelerate the formation of Heinz's body, and that the quantity of such toxins has an important bearing on the estimated values obtained from the blood directly drawn from the patients. Hence in the case of hemorrhagic anemia, the penetrability of Heinz's corpuscles through the wall of erythrocytes should be given an especial consideration. The serum of anemic patient has been found to accelerate the formation of Heinz's body even when made to act directly upon the erythrocytes of the normal persons, in vitro. en-copyright= kn-copyright= en-aut-name=SaitoTetsuro en-aut-sei=Saito en-aut-mei=Tetsuro kn-aut-name=斎藤哲郎 kn-aut-sei=斎藤 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=627 end-page=647 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on Heinz's Body Part One: Hydrogen-Bomb Cases and Experimental Domestic Rabbits Exposd to Radio-activity, both Observed on the Basis of the Appearance of Heinz's Body kn-title=ハインツ氏小体に関する研究 第一編 ハインツ氏小体出現を中心として観たビキニ水爆症及び実験的放射能障碍家兎に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=By determining at first the appearance of Heinz's body in man and male domestic rabbits, both normal, with the Yoshida-Kawamura method, and next by investigating the rate of the appearance of Heinz's body in Bikini hydrogen-bomb patients and in the domestic rabbits injected with radio-isotope P(32) as well as in the rabbits exposed to X-ray, the author obtained the following results: 1. Two separate groups of male and female, each consisting of 25 persons, were selected and the rate of the Heinz-body appearance was determined; and as the result, the average rates of the appearance of each were found to be 63.88‰ (male) and 66.52‰ (female) respectively; thus the average value of females was slightly higher. On the other hand, in the 62 normal male rabbits similarly measured, the average value of the appearance of Heinz's body was found to be 22.19‰. 2. In the case of the 7 fishermen passing through the Bikini area and having shown no apparent clinical disorders, the rate of Heinz-body appearance was found to be still high, yet within 3 to 4 weeks after the examination, it returned to normal, paralleling more or less with the change of blood-iron contents, Sideroblastogram, and the results of Bone marrow tissue culture. In view of this, in establishing a criterion of the recovery of these hydrogenbomb cases, it seems that scrupulous daily examinations such as mentioned previously are of urgent necessity. 3. In the domestic rabbits receiving the injection of 100 μc. P(32)/kg, Heinz's body increased 6 hours after the injection but it returned to normal after 20 to 42 days; even then they maintained a high value of blood-iron contents and showed an unmistakable evidence of radio-active substance in the bone as well. Whereas those rabbits receiving the dose of 850 μc. P(32)/kg showed the increase of Heinz's body either 30 minutes or 3 hours after the injection, and after 48 hours and 28 days respectively their values reached close to 1, 000‰ and continuously showing an intermediately progressive trend, they all died. The blood counts of capillary leucocytes in the case of the rabbit No.58 returned to normal 28 days after the injection, but the percentage of capillary leucocytes, the blood counts of erythrocytes, and the bone picture were still abnormal and radio-active substance could be recognized in the bone. Heinz's body, however, did not appear in the control injected with primary potassium phosphate. 4. Among the 6 rabbits suffering from acute X-ray radiation, and the five from chronic, three of the latter and all the acute cases revealed a progressive proclivity to the formation of Heinz's body before their death. en-copyright= kn-copyright= en-aut-name=SaitoTetsuro en-aut-sei=Saito en-aut-mei=Tetsuro kn-aut-name=斎藤哲郎 kn-aut-sei=斎藤 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=525 end-page=539 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alkylphosphate Poisoning Part III Effect of 2-Pyridine Aldoxime Methiodide (PAM) in the Therapy of Parathion Poisoning kn-title=有機燐製剤中毒に関する研究 第三編 2-pyridine aldoxime methiodideによるParathion中毒治療に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=From the clinical point of view, the effect of PAM are summarized as follows. 1) By the administration of PAM, there occured prompt and complete relief of the symptoms of poisoning. 2) The cholinesterase (ChE) activity of red blood cell was instantly and completely recovered and that of serum was transiently. 3) Generally a intravenous injection of 1g PAM was sufficent and it is to be added if necessary. 4) The side effect has not been experienced. 5) PAM had no influence to the ChE activity of normal blood. 6) PAM is expected to be used as the preventive agent of alkylphosphate poisoning. en-copyright= kn-copyright= en-aut-name=YamadaMinoru en-aut-sei=Yamada en-aut-mei=Minoru kn-aut-name=山田稔 kn-aut-sei=山田 kn-aut-mei=稔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=515 end-page=523 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alkylphosphate Poisoning Part II Studies on the Tissue Cholinesterase in Parathion Poisoning kn-title=有機燐製剤中毒に関する研究 第二編 Parathion中毒の臓器Cholinesteraseに関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The tissue cholinesterase (ChE) activity in normal rabbit was the highest in the central nervous system, and was high following descending order; liver, spleen, erythrocyte, lung, serum, gastrointestinal tract, kidney, heart and muscle. By a subcutaneous parathion injection, there occured the changes of ChE both in the tissues and blood as follows. 1) At the time of death caused by the administration of 100 mg/kg of parathion, the ChE in serum, erythrocyte and central nervous system were inhibited strongly than that in the others and the inhibition of liver ChE was the slightest. 2) On the case of the administration of 5 mg/kg of parathion, the inhibition of ChE was great in blood, slight in the liver and moderate in the central nervous system. On this case, the inhibition of ChE in the tissue was maximum after 6-12 hours, and the restoration of it was after 11 days, but in the kidney both were slower than the others. en-copyright= kn-copyright= en-aut-name=YamadaMinoru en-aut-sei=Yamada en-aut-mei=Minoru kn-aut-name=山田稔 kn-aut-sei=山田 kn-aut-mei=稔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=501 end-page=514 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alkylphosphate Poisoning Part I Experimental Studies on the Toxicity of Alkylphosphate kn-title=有機燐製剤中毒に関する研究 第一編 有機燐製剤の毒性に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The toxicity of emulsified methylparathion, diazinon, chlorthion and sumicide examined in comparison with that of ethylparathion in laboratory rabbit. The results were as follows. 1) All these compounds were absorbed by means of dermal, oral, subcutaneous snd intravenous application. Methylparathion was 1/21/4, chlorthion was 1/31/8 and sumicide was 1/25 as toxic as ethylparathion, but diazinon was toxic as much the same. 2) These compounds produced a marked depression of cholinesterase (ChE) activities of both serum and red blood cell in all subjects examined. The ChE inactivation caused by methylparathion and sumicide slower than that of the others. 3) The main symptoms caused by exposure to these compounds were alike to those produced by ethylparathion. 4) With the application of these compouuds, the changes of hemoglobin and red blood cell count were not remarkable, except in the sumicide case which the decrease of both occured 2 to 3 days after the administration. There occured, as the case of ethylparathion, leucocytosis, mainly occupied by pseudoeosinophils with the deflection of Arneth count to the left as well as relative lymphocytopenia. en-copyright= kn-copyright= en-aut-name=YamadaMinoru en-aut-sei=Yamada en-aut-mei=Minoru kn-aut-name=山田稔 kn-aut-sei=山田 kn-aut-mei=稔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=431 end-page=446 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Epidemiologic and Symptomatologic Observations on the Gastric Cancer Patients (Hospitalized Patients, 1945-1956 and Outpatients, 1954-1955) kn-title=胃癌患者の疫学的並びに症候的観察―昭和20～31年の入院患者並びに昭和29, 30年の外来患者について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Conceding that a great progress of cancer researches is opening up a new phase in the treatment of cancers and realizing an early operation is at the present a sole approach to the gastric-cancer therapy, an early diagnosis seems to be the most important, daily clinical problem we have to face. In view of this we have attempted to grasp the true nature of gastric-cancer patients by a series of epidemiologic and symptomatologic observations statistically on the hospitalized patients during the past 12 years, and outpatients for the past 2 years of our clinic. From our observations we find that the most likely ages of the onset of cancers range from 50 to 60, and that the gastric cancer developing at an early age is found more predominantlyin female. Moreover, in the farm districts, the proportion of female patients far surpasses that of any other occupation. Of all the cancer cases treated during the 12-year periods, the gastric cancer occupied 45 per cent. Of all the outpatients during the two-year periods, 27.8 per cent proved to be suffering from digestive organs; and the gastric cancer cases occupied 5.7 per cent of the latter. Now, it is impossible, simply by its symptoms, to differentiate the gastric cancer from such diseases as the gastric and the duodenal ulcers, and gastritis; as the symptom and chief complaint of the patients at its onset are epigastric pain, the foremost, followed by feeling of full and tension in the epigastrium, and eructation and heart burn, and since all of these have practically no distinguishable difference from those of the latter. Of the total patients, the cases impossible of operation reached as high as 39 per cent while those being operated on but ending only in laparotomy proved to be 15 per cent, and the ones on whom the gastric resection had proved a success were merely 8.8 per cent. It is, moreover, interesting to note that despite as high as 75.8 per cent of the cases having palpable abdominal tumors at the time of admission, the ones whose Virchow's gland and other lymphatic glands had been palpable were extremely little: no more than 0.6 per cent. The occult blood reaction of stool was positive in 71 per cent, and 18 per cent of gastric cancer patients were of either normal or hyper acidity; and 61 per cent of the total had abnormal defecation (constipation, diarrhea, etc.). As for complications, helminthiasis is predominant (30%). This fact is worthy of an attention, for symptoms resulting from helminth's attacks often obscure those of gastric cancer. Reviewing the statistical data so far mentioned, we realize keenly how little early diagnosis of gastric cancer is being carried out and how difficult it is to carry this out; at the same time we have learned, on the other hand, how essential and beneficial it is to grasp epidemiologic and symptomatologic problems for its diagnosis. en-copyright= kn-copyright= en-aut-name=UeharaHideo en-aut-sei=Uehara en-aut-mei=Hideo kn-aut-name=上原偉男 kn-aut-sei=上原 kn-aut-mei=偉男 aut-affil-num=1 ORCID= en-aut-name=OkuhashiAtsumu en-aut-sei=Okuhashi en-aut-mei=Atsumu kn-aut-name=奥橋褒 kn-aut-sei=奥橋 kn-aut-mei=褒 aut-affil-num=2 ORCID= en-aut-name=MoritaniHideo en-aut-sei=Moritani en-aut-mei=Hideo kn-aut-name=森谷秀男 kn-aut-sei=森谷 kn-aut-mei=秀男 aut-affil-num=3 ORCID= en-aut-name=HattoriSusumu en-aut-sei=Hattori en-aut-mei=Susumu kn-aut-name=服部進 kn-aut-sei=服部 kn-aut-mei=進 aut-affil-num=4 ORCID= en-aut-name=UetsukaKaoru en-aut-sei=Uetsuka en-aut-mei=Kaoru kn-aut-name=上塚香 kn-aut-sei=上塚 kn-aut-mei=香 aut-affil-num=5 ORCID= en-aut-name=SanadaHiroshi en-aut-sei=Sanada en-aut-mei=Hiroshi kn-aut-name=真田浩 kn-aut-sei=真田 kn-aut-mei=浩 aut-affil-num=6 ORCID= en-aut-name=MotokuraKiyoshi en-aut-sei=Motokura en-aut-mei=Kiyoshi kn-aut-name=本倉潔 kn-aut-sei=本倉 kn-aut-mei=潔 aut-affil-num=7 ORCID= en-aut-name=HayashiKazuo en-aut-sei=Hayashi en-aut-mei=Kazuo kn-aut-name=林和雄 kn-aut-sei=林 kn-aut-mei=和雄 aut-affil-num=8 ORCID= en-aut-name=MiyaiMonziro en-aut-sei=Miyai en-aut-mei=Monziro kn-aut-name=宮井絞治郎 kn-aut-sei=宮井 kn-aut-mei=絞治郎 aut-affil-num=9 ORCID= en-aut-name=NishiuchiMichio en-aut-sei=Nishiuchi en-aut-mei=Michio kn-aut-name=西内道雄 kn-aut-sei=西内 kn-aut-mei=道雄 aut-affil-num=10 ORCID= en-aut-name=MatsuyamaTsuneo en-aut-sei=Matsuyama en-aut-mei=Tsuneo kn-aut-name=松山恒男 kn-aut-sei=松山 kn-aut-mei=恒男 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=325 end-page=347 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Some Morphological Observation on the Innervation within Bone-Marrows 3rd Chapter On innervation found in the bone-marrow of various mammal's femur (Human, Cows, Cats.) kn-title=骨髓内神経分布に関する形態学的観察 第3編 各種哺乳類（人，牛，猫）の大腿骨骨髄に於ける神経分布 en-subtitle= kn-subtitle= en-abstract= kn-abstract=I have succeeded to obtain results as follows, by taking examination on the nerve distribution within bone-marrows of human, caw's, and cat's femur. 1) In case of human, or cow's femur, the nerve entered into the bone-marrow, together with nutrient artery, forming a thick primary trunk nerve bundle; whence, it branches the secondary trunk nerve bundle, from which again nerve fibres are divided which directly distribute to arterial walls. Moreover, nerve plexus is formed here and there at the arterial walls immediately after its entry; esp., good development can be seen in cow's case. As for a cat's, a thick nerve bundle runs paralell to arteries, derivating from it certain nerve fibres distributed towards arterial walls. Also as to middle arteries, nerve distribution presents most minute, while in the small ones, indicated very poor. 2) In venous system, nerves are merely seen in partial small venous sinusoid, but in a cat's case, it is detected to certain extent. From the above, one may know that even in human, caw. and cat, contraction or enlargement of middle arteries play a most important role for the inhibition or mobilization of blood cells within bonemarrow. 3) The innervation in parenchyma proves very poor for all the three, finding neither nerve plexus nor any terminal reticulum. From all these, nerves are seemed not to have important significance for the formation of blood cells in bone-marrow. en-copyright= kn-copyright= en-aut-name=TanakaMotosuke en-aut-sei=Tanaka en-aut-mei=Motosuke kn-aut-name=田中基介 kn-aut-sei=田中 kn-aut-mei=基介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=12-1 article-no= start-page=7957 end-page=7976 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Iron and Copper Metabolisms in the So-Called Banti's Disease Part 2. Influences of the Anemia-Inducing Agent on the Iron and Copper Metabolisms in the So-Called Banti's Disease kn-title=所謂Banti氏病の鉄及び銅代謝にする研究 第2編 所謂Banti氏病の催貧血性因子の鉄及び銅代謝に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied what influences might be exerted on the iron and copper metabolisms in rabbits by anemia-inducing, substance found in the patient with the so-called Banti's disease, and obtained the following results. 1. In the rabbits injected with the serum or the spleen extract of Banti's disease patients, there can be recognized a decrease in the number of erythrocytes and in the serum iron content and an increase in the serum copper content. 2. After injecting the serum and the spleen extract of the patient to rabbits, the iron and copper contents in the liver and spleen of the animals were measured. From these results as well as from their bone marrow picture, and the serum iron and copper contents it has became clear that the mobilization of the stored iron is disturbed and that the copper metabolism is involved in it. 3. Even in the non-toxic splenomegaly (Tomoda) it has been recognized that there exists an agent that induces changes in the iron and copper metabolisms. en-copyright= kn-copyright= en-aut-name=OkadaYoshio en-aut-sei=Okada en-aut-mei=Yoshio kn-aut-name=岡田由夫 kn-aut-sei=岡田 kn-aut-mei=由夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=12-1 article-no= start-page=7941 end-page=7955 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Iron and Copper Metabolisms in the So-Called Banti's Disease Part 1. On the Serum Iron and Copper Contents, Visceral Iron and Copper Contents, and the Iron and Copper Excreted in the Urine of Patients kn-title=所謂Banti氏病の鉄及び銅代謝にする研究 第1編 患者の血清鉄及び銅量臓器鉄及び銅量並びに尿中排泄鉄及び銅量に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=With 29 patients of the so-called Banti's disease the author carried out clinical investigations mainly on the iron and copper metabolisms, and obtained the following results. 1. In the patients suffering from this disease a decrease in the serum iron content and an increase in the serum copper content can be recognized. 2. In this diseasa the deerease in visceral iron fractions, PI and PII in the liver, is marked, while in the spleen although PII is decreased, PI, on the contrary, is increased. 3. In this disease the gram unit content of visceral copper in the liver is increassed when compared with that in the spleen. 4. The iron content excreted in the urine of this disease is less than that in normal persons, whereas the copper content is greater than that in normal persons. 5. At the time of ACTH-gel test the decrease in the serum iron content and the increase in the serum copper are more marked in the patient than those in normal persons, while on the day and second day of the test the iron and copper contents excreted in the urine of the patient do not decrease so markedly as those in normal person. 6. The serum iron content five minutes after the iron tolerance test shows a lower value in the patient than that in normal person, and likewise the serum copper content shows somewhat a similar decrease. 7. On the basis of these findings the author discussed from various angles the iron and copper metabolism in the patient with this disease. en-copyright= kn-copyright= en-aut-name=OkadaYoshio en-aut-sei=Okada en-aut-mei=Yoshio kn-aut-name=岡田由夫 kn-aut-sei=岡田 kn-aut-mei=由夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-2 article-no= start-page=6827 end-page=6841 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Various Vitamins loaded to Bone-Marrow Tissue Culture Part 3. Effects of Various Vitamins on the Erythrocyte Series kn-title=骨髄組織培養に対する各種ビタミン添加の影響 第3編 各種ビタミンの赤血球系造血に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied the effects of various vitamins on the cells of the erythrocyte series by performing the bone-marrow tissue culture of normal rabbits, and obtained the following results. 1. It has been found that vitamin B(1), cocarboxylase, vitamins B(2) and C, nicotinic acid, and vitamin K possess no power directly increasing the number of the erythrocyte series in the bone marrow. 2. Vitamin B(2) seems to be activated in vivo and transformed to FMN (flavin mononucleotide) or FAD while nicotinic acid in the form of DPN (diphosphophopyridine nucleotide) or TPN (triphosphopyrine nucleotide) can only play a role in the hematopoiesis, and it is believed that these vitamins at least in their original forms can not act directly on the bone marrow as to accelerate erythropoiesis. 3. Folic acid is first activated in vivo and trasformed to citovorum factor, and it is this latter factor that acts on the bone marrow as to accelerate the maturation of erythrocytes, but it does not have any effect on the erythropoiesis of the bone marrow in its original form. 4. FAD and vitamin B(6) have been found to have the power to accelerate erythropoiesis of the bone marrow though only slightly. 5. It has been recognized that vitamin B(12) acts directly on the bone marrow and markedly accelerates erythropoiesis of the bone marrow. 6. All these vitamins tested have no accelerating offect on the hemoglobin synthesis. en-copyright= kn-copyright= en-aut-name=KataokaRyosi en-aut-sei=Kataoka en-aut-mei=Ryosi kn-aut-name=片岡良司 kn-aut-sei=片岡 kn-aut-mei=良司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-2 article-no= start-page=6815 end-page=6825 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Various Vitamins loaded to Bone-Marrow Tissue Culture Part 2. Effects of Various Vitamins on Carbon-particle Phagocytosis and Vital Staining of Pseudoeosinophils kn-title=骨髄組織培養に対する各種ビタミン添加の影響 第2編 各種ビタミンの偽好酸球墨粒貪喰能及び生体染色性に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By performing a series of bone-marrow tissue culture of normal rabbits the author studied the effects of various vitamins on carbon-particle phagocytosis and neutral red vital staining of pseudoeosinophils, and obtained the following results. 1. Cocarboxylase, vitamins B(2) and K have no accelerating effect on carbon-particle phagocytosis of pseudoeosinophils nor any effect on the vital staining, suggesting that these substances have no effect directly accelerating the functions of pseudoeosinophils. 2. Vitamins B(1), B(6) and nicotinic acid in a certain adequate concentration only accelerate the carbon-particale phagocytosis of pseudoeosinophils slightly but no neutral red vital staining effect. 3. With vitamin B(12) and folic acid a marked acceleration of the carbon-particle phagocy tosis and a slight acceleration with FAD and vitamin C can be recognized. Likewise from the standpoint of the neutral red vital staining these seem to possess the accelerating action on the functions of pseudoeosinophils. en-copyright= kn-copyright= en-aut-name=KataokaRyosi en-aut-sei=Kataoka en-aut-mei=Ryosi kn-aut-name=片岡良司 kn-aut-sei=片岡 kn-aut-mei=良司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-2 article-no= start-page=6797 end-page=6813 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Various Vitamins loaded to Bone-Marrow Tissue Culture Part 1. Effects of Various Vitamins on the Tissue Growth and Motility of Pseudoeosinophils kn-title=骨髄組織培養に対する各種ビタミン添加の影響 第1編 各種ビタミンの組織増生並に偽好酸球の運動能に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By loading various vitamins to the bone-marrow tissue culture of normal rabbits the author observed systematically the influences of these vitamins on the cell growth and on the cell function of the leucocyte series, especially on the motility of pseudoeosinophils, and obtained the following results. 1. In vitamin B(1), cocarboxylase, vitamin B(2), and vitamin K there can be found no direct action as to increase the number of cells in the bone marrow leucocyte series. 2. Vitamin B(12) and folic acid have been found to possess a power markedly to increase the number of the leucocyte series in bone marrow. 3. Vitamin C has a moderate power, while FAD (flavin adenine dinucleotide), vitamin B(6), nicotinic acid, and nicotinamide in an adequate concentration only have the power directly increasing the number of the leucocyte series. 4. Vitamins B(1), B(6), and C as well as folic acid have been found to act as to accelerate the wandering velocity of pseudoeosinophils. en-copyright= kn-copyright= en-aut-name=KataokaRyosi en-aut-sei=Kataoka en-aut-mei=Ryosi kn-aut-name=片岡良司 kn-aut-sei=片岡 kn-aut-mei=良司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6539 end-page=6553 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Oxygen Consumption and Glycolysis of Bone Marrow Part 3. The Effects of Antileukemic Agents on the Oxygen Consumption of Rabbit Bone Marrow kn-title=骨髄の呼吸解糖作用に関する研究 第3編 正常家兎骨髄の組織呼吸作用に及ぼす各種抗白血病剤の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With Warburg's apparatus the author studied the effects of the addition of various antileukemic agents such as nitromin, myleran, 8-azaguanine, 6-mercapurine, prednisolone, ACTH, actinomycin C, and carzinophilin directly to the bone marrow of the femur of normal rabbits, and obtained the following results. 1. Nitromin at the concentration of 10(-1)g/dl seems to inhibit the respiration of the bone marrow, and the oxygen consumption every 10 minutes decreases along with laps of the time. 2. Myleran has no effect on the respiration of the bone marrow. 3. 8-azaguanine has likewise no effect on thc respiration of the bone marrow. 4. 6-mereaptopurine at the concentrations of 5×10(-1)g/dl and 5×10(-2)g/dl seems to inhibit the respiration of the bone marrow. 5. Prednisolone at the concentrations of 2×10(-1)g/dl and 2×10(-2)g/dl seems to inhibit the respiration of the bone marrow. 6. ACTH at the concentrations of 2×10(-2)unit/dl, 2×10unit/dl and 2unit/dl seems to accelerate the respiration of the bone marrow. 7. Actinomycin C at the concentration of 2×10(-5)g/dl accelerates the respiration of the bone marrow slightly, but in any other concentration it does not differ from that of the control, suggesting that it does not inhibit the respiration of the bone marrow, 8. Carzinophilin hardly inhibits the respiration of the bone marrow, but at the concentration of 5×10(-4)unit/dl every ten minutes the oxygen consumption somewhat tends to decrease along with lapse of the time. From these it is assumed that nitromin, 6-mereaptopurine and prednisolone at a specific concentration act directly on the bone marrow and inhibit its respiration, but ACTH directly accelerates the respiration of the bone marrow and thus enhances the hematopoietic fucntion. en-copyright= kn-copyright= en-aut-name=SanadaHiroshi en-aut-sei=Sanada en-aut-mei=Hiroshi kn-aut-name=真田浩 kn-aut-sei=真田 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6523 end-page=6538 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Oxygen Consumption and Glycolysis of Bone Marrow Part 2. A Study on the Glycolysis of the Sternal Bone Marrow in Various Leukemias kn-title=骨髄の呼吸解糖作用に関する研究 第2編 各種白血病患者胸骨穿刺液の解糖作用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the sternal bone marrow obtained from various leukemias definitely diagnosed by their bone-marrow tissue culture the author measured the glycolysis in the sternal bone marrow and obtained the following results. 1. Anaerobic glycolysis of 0.2 cc/hr sternal bone marrow in leukemia is markedly increased as compared with that in normal persons, and the grads of such an increase differs according to the form of diseases. Pointing out the form of leukemias from the greater to the lesser acceleration in the anaerobic glycolysis, they are in the order of acute lymphocytic leukemia, acute myelogenous leukemia, monocytic leukemia, chronic myelogenous leukemia and chronic lymphocytic leukemia. 2. The acceleration of X(M)(N)(2)/K is most marked in acute myelogenous leukemia followed by monocytic leukemia, and in chronic myelogenous leukemia it is close to the normal value, while in lymphocytic leukemia it is less than the normal value. In the case with a higher percentage of immature cells there is an increasing tendency in X(M)(N)(2)/K. 3. With a single exception of chronic lymphocytic leukemia Q(M)(N)(2) is accelerated in every form of leukemia, and in pointing out the ones with marked acceleration and down they are in the order of acute lymphocytic leukemia, acute myelogenous leukemia, monocytic leukemia, and chronic myelogenous leukemia. Moreover, those with greater number of nucleated cells and a higher percentage of immature cells in bone marrow the value of Q(M)(N)(2) tends to be greater. 4. The aerobic glycolysis in leukemia does not show any marked difference from that in arachnoiditis adhaesiva, idiopathic ardiaspasmus, diabetes mellitus, hookworm disease, hypoplastic anaemia and Banti's syndrome. 5. The ratio between the oxygen consumption and anaerobic glycolysis (Q(M)(N)(2)/Qo(2)), though less than that in malignant tumor, is higher than normal. This increase is especially marked in acute leukemia but slight in chronic leukemia, and in monocytic leukemia it is intermediate between the acute leukemia (myelogenous and lymphocytic) and the chronic leukemia (myelogenous and lymphocytic). Namely, the anaerobic glycolysis in the leukemic bone marrow is accelerated as compared with that in normal bone marrow, but the grade of such an increase differs according to the form of diseases; and it is most prominent in acute leukemia; relatively slight in chronic leukemia; and it is intermediate between the acute and the chronic in monocytic leukemia. The value of Q(M)(N)(2)/O(2) indicates that the metabolism of leukemia is intermediate between the normal bone marrow and that in malignant tumor. en-copyright= kn-copyright= en-aut-name=SanadaHiroshi en-aut-sei=Sanada en-aut-mei=Hiroshi kn-aut-name=真田浩 kn-aut-sei=真田 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6507 end-page=6521 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Oxygen Consumption and Glycolysis of Bone Marrow Part 1. A Study on the Oxygen Consumption of the Sternal Bone Marrow in Various Leukemias kn-title=骨髄の呼吸解糖作用に関する研究 第1編 各種白血病患者胸骨穿刺液の呼吸作用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By measuring the oxygen consumption in the sternal bone marrow of various leukemias definitely diagnosed on the basis of their bone-marrow tissue culture, the author obtained the following results. 1. In leukemia the oxygen consumption of 0.2 cc/hr sternal bone marrow shows an increase as compared with that of normal persons, and the degree of this increase differs according to the form of diseases. The grade of such an increase is in the descending order of that in acute myelogenous leukemia, chronic myelogenous leukemia, acute lymphocytic leukemia, monocytic leukemia and chronic lymphocytic leukemia. Xo(2)/K in comparison with that in the normal case is increased in acute myelogenous leukemia and monocytic leukemia, but in chronic myelogenous leukemia it is somewhat decreased, and in acute and chronic lymphocytic leukemia it is markedly decreased. Qo(2) is increased in all leukemia as compared with that of normal case, and its increase is in the descending order of that in monocytic leukemia, acute myelogenous leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, and chronic lymphocytic leukemia. 2. There is a parallel relation between the oxygen consumption, the nucleated cell count, and the immature cell percentage of the bone marrow, and moreover, in chronic myelogenous leukemia at remission due to the treatment the oxygen consumption is also reduced. 3. As for the oxygen consumption of peripheral erythrocytes in chronic myelogenous leukemia it is at the normal level, but in all others it is slightly reduced. en-copyright= kn-copyright= en-aut-name=SanadaHiroshi en-aut-sei=Sanada en-aut-mei=Hiroshi kn-aut-name=真田浩 kn-aut-sei=真田 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6311 end-page=6319 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukemia Part 3. Iron Loading Tests for the Patients with Various Leukemias kn-title=白血病に関する研究 第3編 各種白血病患者に対する鉄負荷試験について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author made a comparative study of serum iron and serum copper contents in various leukemias that had been definitely diagnosed by their bone-marrow tissue culture conducted in our department. Simultaneously the author performed the intravenous iron loading tests and the iron-absorption tests with various leukemias, and obtained the following results. However, in the present comparative study on the serum iron and copper, chronic lymphocytic leukemia is excluded as the number of such cases were too small. 1. In comparing the average value of the serum iron content, acute lymphocytic leukemia shows the greatest value, followed by those of acute myelogenous leukemia, monocytic leukemia, and chronic myelogenous leukemia in the descending order mentioned. The serum copper content is greatest in acute lymphocytic leukemia, and in the descending order of monocytic leukemia, acute myelogenous leukemia, and chronic myelogenous leukemia. Judging monocytic leukemia from the standpoint of its serum iron content, this type also proves to be an intermediary type between acute type and chronic type. 2. In the intravenous iron-loading tests and iron-absorption tests of various leukemias the increased content and decreased content in either case proved to be lower. Moreover, the serum copper content by the iron-loading tests shows hardly any change. 3. In the iron-loading tests likewise no difference can be recognized in various types of leukemia. en-copyright= kn-copyright= en-aut-name=MatsuyamaTsuneo en-aut-sei=Matsuyama en-aut-mei=Tsuneo kn-aut-name=松山恒男 kn-aut-sei=松山 kn-aut-mei=恒男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6293 end-page=6309 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukemia Part 2. Clinical and Statistical Observations of the Peripheral Blood Picture in Various Leukemias kn-title=白血病に関する研究 第2編 各種白血病に於ける末梢血液像に関する臨床統計的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author carried out clinical and statistical observations of the peripheral blood picture in various leukemias occurring in the Chugoku-Shikoku District, with a special reference to the comparative study on the two groups treated in our department, namely, the group whose bone marrow was cultured and the other without such a culture finding. However, cases of chronic lymphocytic leukemia are not included in the present statistics as their number was trivial. 1. Hb content and erythrocyte count: The decrease in Hb content and erythrocyte count is most marked in acute myelogenous leukemia, followed by acute lymphocytic leukemia, and it is least in chronic myelogenous leukemia. The decrease in Hb and erythrocytes of monocytic leukemia occupies an intermediate position between the above two. 2. The color index: The color index is comparatively high in acute type while it tends to be lower in chronic type. 3. Leucocyte count: The aleukemic form is greatest in monocytic leukemia followed in descending order of that in acute lymphocytic leukemia and acute myelogenous leukemia, and all of these aleukemic ones occupy more than 1/3 of the total. However, in chronic myelogenous leukemia it is extremely rare to find the aleukemic form. 4. Reticulocyte count: The reticulocyte count in the peripheral blood of leukemia is generally normal or is increased. 5. Platelet count: The platelet count is about at the normal level in chronic myelogenous leukemia, and in some it is increased. However, it is decreased in all other leukemias. In monocytic leukemia it resembles that in acute type. 6. Classification of leucocytes: In acute myelogenous leukemia myeloblasts occupy a greater proportion and also matured leucocytes are quite many. Intermediate immature cells are low in percentage but it is rare not to see any intermediate immature cells. In chronic myelogenous leukemia mature neutrophils are numerous but immature neutrophils are a few in number. In acute lymphocytic leukemia a high percentage of lymphatic cells accompanied by a marked increase in lymphoblasts can be observed. In monocytic leukemia intermdiate mature cells are in a low proportion, and monoblasts are less than in acute type, presenting the characteristic intermediate between acute type and chronic type. Namely, monocytic leukemia is an intermediate type between acute leukemia and chronic leukemia, and it is difficult to divide it into acute and chronic types. 7. Relationship between the leucocyte count and leucocyte percentage: On the whole the increase in the number of leucocytes and myeloblast percentage show a mutual relationship. In monocytic leukemia those whose increase in the number of leucocytes is more marked show a greater number of monoblasts, approaching to the acute type. 8. Relationship between the leucocyte count and platelet count: There can be seen no relationship between the leucocyte count and platelet count. 9. Relationship between the leucocyte count and swelling of the spleen and lymph nodes: In acute lymphocytic leukemia the more marked is the increase in the number of leucocytes the greater is the palpitation frequency and the degere of swelling of the spleen and lymph nodes. In chronic myelogenous leukemia the degree of splenomegaly increases along with the increase in the nmnber of leucocytes. en-copyright= kn-copyright= en-aut-name=MatsuyamaTsuneo en-aut-sei=Matsuyama en-aut-mei=Tsuneo kn-aut-name=松山恒男 kn-aut-sei=松山 kn-aut-mei=恒男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6283 end-page=6292 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukemia Part 1. Clinical and Statistical Observations of the Hemomyelogram in Various Leukemias kn-title=白血病に関する研究 第1編 各種白血病に於ける骨髄像に関する臨床統計的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the present report are presented the results of the clinical and statistical observations conducted on the hemomyelogram of various leukemias occurring in the Chugoku-Shikoku District, with a special reference to the comparative studies carried on the bone marrow of patients treated in our department, handling the cases in which bone-marrow tissue culture was conducted and those without the tissue culture separately. It is to be noted that chronic lymphocytic leukemia is not included in the present study as the number of such cases was to small. 1. In every leukemia generally immature cells are markedly increased in number; in acute leukemia blast cells occupy the major proportion; and in chronic leukemia young leucocytes in various stages of maturation are mixed. 2. Judging from the hemomyelogram, all cases of monocytic leukemia seems to occupy an intermediate position between acute leukemia and chronic leukemia. Hence it is difficult to divide it definitely as an acute leukemia or a chronic one. 3. It is worthy of attention that monocytic leukemia in the cases given no bone-marrow tissue culture occupies only 9.8 per cent of the total leukemia, whereas the same in the cases given the bone-marrow tissue culture occupies as much as 45.5 per cent of the total leukemia. Namely, it is to be noted that without the bone-marrow tissue culture it is often difficult to diagnose monocytic leukemia correctly and it is often mistaken for other leukemias, especially for acute myelogenous leukemia. en-copyright= kn-copyright= en-aut-name=MatsuyamaTsuneo en-aut-sei=Matsuyama en-aut-mei=Tsuneo kn-aut-name=松山恒男 kn-aut-sei=松山 kn-aut-mei=恒男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6247 end-page=6266 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on a Few Chemical Substances in Blood Diseases Part 2. Serum ChE Activity and Erythrocyte ChE Activity in blood diseases kn-title=血液疾患血液の2, 3化学的測定に関する研究 第2編 血液疾患の血清並びに赤血球コリンエステラーゼ活性値について en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. The serum cholinesterase (ChE) activity in various blood disease generally shows a decreasing tendency, and it is marked in the acute form of leukemia. However, there can be recognized no special correlation between the serum ChE activity and the liver funktion and serum protein fractions. The serum ChE activity in blood diseases reflects well the clinical symptoms. 2. For the determination of the erythrocyte ChE activity in various blood diseases the author studied it by calculating the ChE activity value in a given unit of erythrocyte. As the result it has been found that in general the erythrocyte ChE activity in blood diseases shows an increasing tendency, and such a tendency is most marked in the acute form of leukemia. 3. When the administration of various drugs and blood transfusion prove effective on the fluctuations of the serum ChE activity and erythrocyte ChE activity in the course of treatment, these activities regain the normal level along with the recovery of anemia. The same trend can be recognized even in the experimental anemia. en-copyright= kn-copyright= en-aut-name=NiiyaTetsuo en-aut-sei=Niiya en-aut-mei=Tetsuo kn-aut-name=新谷哲男 kn-aut-sei=新谷 kn-aut-mei=哲男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END