start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=7 article-no= start-page=15 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=『行人』における一郎の懐疑 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院文学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=9 article-no= start-page=34 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=『草枕』の美に対する一考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=10 article-no= start-page=116 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=漱石の見た明治社会の風潮 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山県立邑久高等学校 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=11 article-no= start-page=53 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=漱石と虚子――作家漱石の誕生―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山県立邑久高等学校 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=12 article-no= start-page=165 end-page=176 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=「夢十夜」を読む――「ひっかかり読み」を用いて―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山県立邑久高等学校 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=13 article-no= start-page=38 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19850331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=夏目漱石の経済感覚――他者への経済援助―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=14 article-no= start-page=53 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=夏目漱石の経済感覚（その二）――自分の力で獲得するもの―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=山形県立米沢女子短期大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=15 article-no= start-page=41 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19870331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=夏目漱石の経済感覚（その三）――漱石経済生活の実際―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=山形県立米沢女子短期大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=16 article-no= start-page=34 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=19880331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=正宗白鳥の眼力 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智美保 kn-aut-sei=越智 kn-aut-mei=美保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学文学部卒業 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=19 article-no= start-page=126 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=「完璧な病室」――閉じた世界と開かれた世界―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山商科大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=22 article-no= start-page=213 end-page=223 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=「彼岸過迄」――須永市蔵の孤独―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山商科大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=33 article-no= start-page=43 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=『夢十夜』を読む――「第七夜」西へ向かう船―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山商科大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=36 article-no= start-page=36 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=『夢十夜』を読む――「第八夜」鏡に映る現実世界―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智悦子 kn-aut-sei=越智 kn-aut-mei=悦子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山商科大学法学部 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20171227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=メラトニンによる下垂体プロラクチン分泌調節メカニズムの研究 kn-title=Regulatory role of melatonin and BMP-4 in prolactin production by rat pituitary lactotrope GH3 cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OchiKanako en-aut-sei=Ochi en-aut-mei=Kanako kn-aut-name=越智可奈子 kn-aut-sei=越智 kn-aut-mei=可奈子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=1 article-no= start-page=23 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes of colonic mucosa caused by long-term use and discontinuation of anthraquinone kn-title=アントラキノンの長期連用，及び摂取中止が大腸粘膜に与える影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Anthraquinone, an anthracene derivatives, is widely used as a purgative medicine. The long-term use of anthraquinone is known to cause melanosis coli and elevated lesions in the colon. However, the clinical course of patients who take anthraquinone over a long term and those who discontinue the drug has not been fully investigated. Here we investigated 22 patients who had colonic mucosal changes ( i.e., melanosis coli and elevated lesions) who had been taking anthraquinone for at least one year and discontinued it. We classified the elevated lesions into two subtypes:the small-lesion, which included multiple small nodules that were ＜ 2 mm in dia., and the large-lesion, which included a single or multiple nodules of ? 2-mm dia. We used colonoscopy to investigate the changes of colonic lesions between before and after the discontinuation of anthraquinone. The results indicated that the nodules of the small-lesion group were lymphoid follicle hyperplasia. In the large-lesion group, adenoma was most frequently observed ( n＝118) , followed by hyperplastic polyp ( n＝52) and inflammatory changes with edema ( n＝22) . Melanosis coli and elevated lesions were decreased or invisible after the discontinuation of anthraquinone. Our findings thus suggest that the long-term use of anthraquinone may cause some type of elevated lesions due to chronic inflammation. It is recommended that the use of anthraquinone be limited to a short term. en-copyright= kn-copyright= en-aut-name=IwanoEiji en-aut-sei=Iwano en-aut-mei=Eiji kn-aut-name=岩野英二 kn-aut-sei=岩野 kn-aut-mei=英二 aut-affil-num=1 ORCID= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=3 ORCID= affil-num=1 en-affil=Kamogata Clinic kn-affil=鴨方クリニック affil-num=2 en-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 affil-num=3 en-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 en-keyword=アントラセン誘導体（anthracene derivatives) kn-keyword=アントラセン誘導体（anthracene derivatives) en-keyword=アントラキノン（anthraquinone） kn-keyword=アントラキノン（anthraquinone） en-keyword=大腸黒皮症（melanosis coli） kn-keyword=大腸黒皮症（melanosis coli） en-keyword=大腸メラノーシス（pseudomelanosis coli） kn-keyword=大腸メラノーシス（pseudomelanosis coli） en-keyword=リンパ濾胞過形成（lymphoid follicle hyperplasia） kn-keyword=リンパ濾胞過形成（lymphoid follicle hyperplasia） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=雄の性機能を調節する脊髄ガストリン放出ペプチド系の神経ネットワークとその性差構築機構に関する研究 kn-title=Studies on the sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that controls male reproductive function en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OchiTakumi en-aut-sei=Ochi en-aut-mei=Takumi kn-aut-name=越智拓海 kn-aut-sei=越智 kn-aut-mei=拓海 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ゲフィチニブ耐性非小細胞肺癌におけるSrcを介したERK再活性化 kn-title=Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OchiNobuaki en-aut-sei=Ochi en-aut-mei=Nobuaki kn-aut-name=越智宣昭 kn-aut-sei=越智 kn-aut-mei=宣昭 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue= article-no= start-page=51 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20051115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nutritional Status of Disabled Athletes - Dietary and Supplemental lntakes - kn-title=身体障害者スポーツ選手の食事・サプリメント摂取状況に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=近年,サプリメントと呼ばれる栄養補助食品が,日常生活でもスポーツの世界でも非常に流行し,サプリメントについて正しく認識していくことはスポーツ選手にとって重要である｡また,近年障害者スポーツの人気が高まり,岡山でも全国障害者スポーツ大会を目指し,医科学サポートを展開している｡そこで本研究では,岡山県の身体障害者スポーツ選手を対象に,栄養摂取状況･食生活･サプリメントに関する調査を行った｡その結莱,スポーツ選手 として適切な食事･食生活が送れているとは言えず,サプリメントに関しては積極的に使用していという現状が明らかになった｡今後は単なる食事や栄養指導だけでなく,スポーツ選手の食生活やサプリメントに関する指導も含めた栄養サポートが必要である｡ en-copyright= kn-copyright= en-aut-name=MiuraKoji en-aut-sei=Miura en-aut-mei=Koji kn-aut-name=三浦孝仁 kn-aut-sei=三浦 kn-aut-mei=孝仁 aut-affil-num=1 ORCID= en-aut-name=IshiyamaTaizo en-aut-sei=Ishiyama en-aut-mei=Taizo kn-aut-name=石山泰三 kn-aut-sei=石山 kn-aut-mei=泰三 aut-affil-num=2 ORCID= en-aut-name=OritaYasushi en-aut-sei=Orita en-aut-mei=Yasushi kn-aut-name=織田靖史 kn-aut-sei=織田 kn-aut-mei=靖史 aut-affil-num=3 ORCID= en-aut-name=OchiEisuke en-aut-sei=Ochi en-aut-mei=Eisuke kn-aut-name=越智英輔 kn-aut-sei=越智 kn-aut-mei=英輔 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学教育学部保健体育講座 affil-num=2 en-affil= kn-affil=Department of English Language Education, Faculty of Education, Okayama University affil-num=3 en-affil= kn-affil=Tamano Institute of Health and Human Services affil-num=4 en-affil= kn-affil=The University of Tokyo, Graduate School of Art and Science, Laboratory of Sports Science en-keyword=サプリメント kn-keyword=サプリメント en-keyword=障害者スポーツ kn-keyword=障害者スポーツ en-keyword=バリアー kn-keyword=バリアー en-keyword=栄養サポート kn-keyword=栄養サポート END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=4 article-no= start-page=794 end-page=805 dt-received= dt-revised= dt-accepted= dt-pub-year=1930 dt-pub=19300430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die Entwicklung von Loxogenes liberum Seno kn-title=淡水棲昆蟲ヲ中間宿主トセル吸蟲ノ1新被嚢幼蟲ノ研究續報（Loxogenes liberum.ノ發育史ニ就テ） en-subtitle= kn-subtitle= en-abstract= kn-abstract=Loxogenes liberum ist zuerst von Seno (1907) im Darm von Rana nigromaculata aufgefunden worden. Aber ?ber seine Entwicklung ist bisher nichts bekannt. Verf. hat bei in S?sswasser lebenden Insektenlarven, Orthetrum japonicum Uhler, Laccotrephes ruber Linn?, Kirkaldia deyrollii Vuillefroy und einer unbekannten Art, mehrere Trematoden in encystiertem Zustande gefunden. Durch F?tterungsversuche dieser wurde festgestellt, dass die Larve sich im Darm von Rana nigromaculata zur geschlechtsreifen From von Loxogenes liberum entwickelt, und sich experimentell ferner auf folgende Froscharten gut ?bertragen l?sst: Rana rugosa, Rana japonica, Bufo vulgaris japonicus. en-copyright= kn-copyright= en-aut-name=OchiSigeru en-aut-sei=Ochi en-aut-mei=Sigeru kn-aut-name=越智シゲル kn-aut-sei=越智 kn-aut-mei=シゲル aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=神戸船員病竝熱帯病研究所 END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=3 article-no= start-page=617 end-page=627 dt-received= dt-revised= dt-accepted= dt-pub-year=1930 dt-pub=19300331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchungen ?ber die Wirderstandsf?higkeit der encystierten Cercarien von Heterophyes heterophyes kn-title=Heterophyes heterophyes被嚢幼蟲ノ抵抗力ニ關スル實驗的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Es wurden ?ber die Widerstandsf?higkeit der encystierten Cercarien von Heterophyes heterophyes gegen die Einwirkung der verschiedenen Speisen und die physikalischen und chemischen Beeinflussungen experimentelle Untersuchungen angestellt. Die Resultate sind folgende: 1. Die encystierten Cercarien behielten ihre Lebensf?higkeit, wenn sie auch 15 Stunden in Sojasauce, 24 Stunden in Essig, 48 Stunden in Miso, 36 Stunden in Sauer-Miso oder 4 Tage in 5% ige Kochsalzl?sung eingelegt wurden. Eine 4 t?gige Einlegung in 10% ige Kochsalzl?sung oder eine 2 t?gige Einlegung in ges?ttigte Kochsalzl?sung beseitigte dagegen die Infektionsf?higkeit der Cercarien. 2. Wenn die encystierten Cercarien mit dem Fischfleisch zusammen entweder in erw?rmtes Wasser-20 Sekunden um 100°C, 3 Minuten um 80°C oder 7 Minuten um 50°C-eingetaucht oder mittelm?ssig ger?stet wurden, so ging ihre Infektionsf?higkeit verloren, w?hrend sie dagegen in der Eisk?lte bis zu 8 Tagen noch gut erhalten blieb. 3. Die k?nstlich isolierten encystierten Cercarien waren 3 bis 7 Tage in S?sswasser oder 4 bis 7 Tage in Meerwasser noch lebensf?hig. 4. Bei 18 st?ndiger Einlegung in k?nstlichen Magensaft blieben die Cercarien noch infektionsf?hig. en-copyright= kn-copyright= en-aut-name=OchiSigeru en-aut-sei=Ochi en-aut-mei=Sigeru kn-aut-name=越智シゲル kn-aut-sei=越智 kn-aut-mei=シゲル aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=神戸船員病竝熱帯病研究所 END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=2 article-no= start-page=388 end-page=402 dt-received= dt-revised= dt-accepted= dt-pub-year=1930 dt-pub=19300228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die Entwicklungsgeschichte von Mesocoelium brevicaeum n. sp. kn-title=本邦産蝸牛ヲ中間宿主トセルー新吸蟲-Mesocoelium brevicaecum n. sp.-竝其ノ發育史ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verf. fand im Darmkanal von Bufo vulgaris japonicus mehrere Exemplare einer bisher nicht beschriebenen Trematodenart, Mesocoelium brevicaecum n. sp. Der Zwischenwirt des Wurmes ist eine Schneckenart, Euhadra quaesita (Deshayes), in der sich die Cercarien im Innern von Sporocysten entwickeln und sich z. T. hier encystieren. Als Endwirt wurden ferner folgende Tiere best?tigt: Rana nigromaculata Hallowell, Rana rugosa Schlegel, Rana catesbiana Shaw, Elaphe quadrivirgata (Boie), Eumeces latiscutatus (Hallowell). en-copyright= kn-copyright= en-aut-name=OchiSigeru en-aut-sei=Ochi en-aut-mei=Sigeru kn-aut-name=越智シゲル kn-aut-sei=越智 kn-aut-mei=シゲル aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=神戸船員病竝熱帯病研究所 END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=10 article-no= start-page=2207 end-page=2220 dt-received= dt-revised= dt-accepted= dt-pub-year=1939 dt-pub=19391031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Beitr?ge zur Kenntnis von Sinus caroticus. (II. Abschnitt) ?ber die Regulierung der Atmmung. kn-title=頸動脈竇ニ關スル研究補遺 其ノ2 呼吸調節作用ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Wenn man verschiedene Kaninchen, d.h. die normalen, die Depressoren-entfernten und die Sinusnerven (Hering)-abgeschnittenen Kaninchen in einem Unterdruckzylinder legt und dessen Innenluftdruck allm?hlich herabsetzen l?sst, so ergibt bei den normalen sowie Depressoren-verlorenen Kaninehen eine dementsprechende Zunahme der Atemzahl, die aber bei den Sinusnerven-abgeschnittenen nicht zum Vorschein kommt. Aber selbst bei diesen an Sinusnerven lackenden Kaninchen tritt diese Reaktion gegen dem Unterdruck, d.h. die Zunahme der Atemzahl im Verlaufe von ?ber 24 Stunden nach der Operation wieder ein. Hierbei ist jedoch die Reaktionsweise der Atmung etwas anders als vor der Operation. Der Verfasser nimmt an, dass diese Erscheinung haupts?chlich auf die kompensatorische Wirkung irgend welches anderes Organe zur?ckzuf?hren ist. en-copyright= kn-copyright= en-aut-name=OtiYukio en-aut-sei=Oti en-aut-mei=Yukio kn-aut-name=越智幸雄 kn-aut-sei=越智 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=10 article-no= start-page=2200 end-page=2207 dt-received= dt-revised= dt-accepted= dt-pub-year=1939 dt-pub=19391031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Beitr?ge zur Kenntnis von Sinus caroticus. (I. Abschnitt) ?ber die Regulierung des Blutdruckes. kn-title=頸動脈竇ニ關スル研究補遺 其ノ1 血壓調節作用ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser f?hrte einige Untersuchungen aus ?ber die Blutdruckver?nderungen nach Ausschaltung der Sinusnerven (Hering) bei Kaninchen, die mit Urethan leichtgradig narkotisiert waren. Folgendes sind die Hauptz?ge der Resultate: 1) Nach Ausschaltung der Sinusnerven steigt der Blutdruck an. Die Drucksteigerung nach einseitiger Ausschaltung betr?gt durchschnittlich 8.9% des Anfangsdruckes, und das AusmaB der Steigerung nach Ausschaltung von rechts ist etwa eben so groB, wie hei der von links. Nach doppelseitiger Ausschaltung der Nerven steigt der Blutdruck um durchschnittlich 23.6% des Anfangswrtes an. Das AusmaB der Blutdruckerh?hung nach doppelseitiger Ausschaltung betr?gt mehr als das doppelte. derjenigen, die einseitiger Manipulation erfolgt. Aus diesen Resultaten k?nnen wir folgern, daB die Sinusnerven bei normalem Blutdrucke Tonus haben und daB zwischen den Sinusnerven der beiden Seiten eine Kompensation besteht. 2) Die Blutdrucksteigerung, die infolge von Adrenalininjektion auftritt, ist nach der Ausschaltung der Sinusnerven gr?Ber, als vorher. Das Maximum der Blutsteigerung ist bei ersterer um 13.9% h?her, als bei letzterer. Der Verlauf der R?ckkehr des erh?hten Blutdruckes zur Anfangsh?he wird nicht beeinfluBt durch Ausschaltung der Nerven. en-copyright= kn-copyright= en-aut-name=OtiYukio en-aut-sei=Oti en-aut-mei=Yukio kn-aut-name=越智幸雄 kn-aut-sei=越智 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=11 article-no= start-page=2591 end-page=2597 dt-received= dt-revised= dt-accepted= dt-pub-year=1940 dt-pub=19401130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Einfluss von Azetylcholin oder Adrenalin auf die den Spinalreflex steigernde Wirkung von Strychnin kn-title=Strychnlnノ反射亢進作用ニ及ボスAzetylcholin及ビAdrenalinノ影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Verfasser stellte einen Versuch am Kr?te und Frosch an. Dabei nahm er wahr, dass Azetyleholin oder Adrenalin auf den gesteigerten R? ckenmarksreflex durch Strychnin hemmenden Einfluss auszu?ben. en-copyright= kn-copyright= en-aut-name=OtiYukio en-aut-sei=Oti en-aut-mei=Yukio kn-aut-name=越智幸雄 kn-aut-sei=越智 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=10 article-no= start-page=2389 end-page=2395 dt-received= dt-revised= dt-accepted= dt-pub-year=1940 dt-pub=19401031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Einfluss von Azetylcholin oder Adrenalin auf den Spinalreflex kn-title=Azetylcholin及ビAdrenalinノ脊髓反射ニ及ボス影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bei dem Experiment, wo man Kr?te und Frosch benutzt, wirkt Azetylcholin oder Adrenalin auf das R?ckenmark und zwar hemmend die Reizbarkeit des Spinaireflexes. Eben so wirkt hemmend Ergotamin auf die Reizbarkeit des Spinalreflexes von Kr?te. Verwendet man aber bei Kr?te, Ergotamin mit Azetylcholin oder Adrenalin beisammen, so wirken die beide Mitteln im Gegensatz zum vorigen Fall bef?rderd auf dem Spinalreflex. en-copyright= kn-copyright= en-aut-name=OtiYukio en-aut-sei=Oti en-aut-mei=Yukio kn-aut-name=越智幸雄 kn-aut-sei=越智 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=6 article-no= start-page=1404 end-page=1411 dt-received= dt-revised= dt-accepted= dt-pub-year=1940 dt-pub=19400630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber eine Ursache der roten Blutk?rperchenzuname bei niedrigem Druck kn-title=低壓下ニ於ケル赤血球増加ノ1原因ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Verfasser mass die Ver?nderung der roten Blutk?rperchenzahl und des H?moglobingehaltes von Frosch, welehes in einem Kammer unter Luftdruckerniedrigung einige Zeit geblieben war. Die Resultatc lassen sich folgendermassen zusammenfassen. 1) Bei dem Aufenthalt im Unterdruckkammer (-300mm Hg) w?hrend einer Stunde, nahmen die rote Blutk?rperchenzahl um 11.7%, und der H?moglobingehalt um 9.9% zu. 2) Bei dem Aufenthalt im Unterdruckkammer (-300mm Hg) w?hrend 4 Stunden, tratt das im Gef?sse injizierte Schwerwasser (D2O) durch die Froschhaut des Unterschenkels hervor um 6.1% mehr als bei normalen. 3) Daraus stellt man fest-dass die Zunahme des Wasseraustrittes durch Gef?sswand und die dadurch verursachte Eindickung des Blutes eine Rolle f?r die obengenannten Tatsachen spielen. en-copyright= kn-copyright= en-aut-name=OtiYukio en-aut-sei=Oti en-aut-mei=Yukio kn-aut-name=越智幸雄 kn-aut-sei=越智 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=5 article-no= start-page=1013 end-page=1020 dt-received= dt-revised= dt-accepted= dt-pub-year=1940 dt-pub=19400531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Wassergehalt des Blutes bei der Ver?nderung der Umgebungstemperatur kn-title=環境温度ノ高低ニヨル家兎血液ノ水分含量ノ變化ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Verfasser hat den Versuch ?ber den Wassergehalt des Kaninchenblutes angestellt und kam zum folgenden Resultat. 1) Der Wassergehalt des Blutes aus dem Gef?sse von dem Kaninchenohr war je nachdem das Kaliber des Gef?sses verschieden, und nahm durch die Gef?ssdilatation ab. 2) Der Wassergehalt des Blutes aus dem. Gef?sse von Kaninchenohr war von der Ver?nderung der Umgebungstemperatur abh?ngig, indem bei der Temperatursteigerung immer sich zunehmend. Diese Zunahme war aber so geringf?gig, dass die durch gleichzeitig hervortretende Gefassdilatation herbeigefuhrte Abnahme des Wassergehaltes manchmal ?ber kompendiert wird. 3) Der Wassergehalt des Blutes aus dem Herzen nahm auch bei der Steigerung der Umgebungstemperatur zu. en-copyright= kn-copyright= en-aut-name=OtiYukio en-aut-sei=Oti en-aut-mei=Yukio kn-aut-name=越智幸雄 kn-aut-sei=越智 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=1 article-no= start-page=1 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Einfluss der Belichtung eines Auges auf die erregbarkeit des andern kn-title=1眼ニ與ヘル光刺戟ノ他眼ノ機能ニ及ボス影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=?ber die im Titel stehenden Frage sind die Ansichten von vielen Autoren nochn nichnt einig. Da diese Tatsache fur dit verschiedenen Problemen fupdamental wichttig ist, machte der Verfasser eine systematische Untersuchung. Das Resultat ist folgendermasen: 1) Der Schwellenwert eines Auges unter dem Einfluss der Belichtung mit Weissem Licht (20-40 Watts) des andern steigt betrachtlich. Aber die ?nderung der Lichtst?rke um zweifach zeigte keine nennenswerte ?nderung. Auf die Ausschaltung der Belichtung anderes Auges kehrt der Schwellenwert zum normalen. 2) Wenn man den obigen Versuch unter dem bunten Licht, z.B. rotem Licht untersucht, bekommt man ebenso die Steigerungdes Schwellenwertes eines Auges bei der Verst?rkunhg der farbigen Beleuchtung des anderen Auges. Merkw?rdigerweise ist diese Steigerung des Schwellenwertes eines Auges im Falle der Belichtung mit dem Komplement?rfarbe, z.B. Gr?n gegen Rot an den anderen Auge, gleich wie vorogem Versuch. 3) Wenn man bei diesem Versuch den Schwellenwert f?r den bunten Ton, z.B. rote Empfindung bestimmt, so bekommt man den niedrigsten Wert bei der dunkeladaptierten Auge. Bei der Verst?rkung der bunten Beleuchtung des anderen Auges bekommt man den h?heren Wert and beider Beleuchtung mit dem Gegenfarbe des anderen Auges den zwischenliegenden Schwellenwert. 4) Wenn einem Auge ein farbiges Licht einwirken lasst, so irgendeiner Weise hervorgerufene gleichfarbiger Nachbild da.uert l?nger als dem Falle ohne vorherige Beleuchtung. Am Falle mit der vorherigen Beleuchtung mit der Gegenfarbe verk?rzt die Nachbilddauer. Die Beleuchtung mit dem farbigen Licht einseitiges Auges beeinflusst die Nachbilddauer anderseitiges Auges ist gleich wie obigem. Versuch, aber die Grade ist viel weniger. Mit diesem Versuche best?tigt der Verfasser folgende Tatsache; die Erregung einseitiges Auges herabsetzt die Erregbarkeit anderseitiges Auges. Die Beeinflnssung ist im gr?ssenteils mit der HeriDgschen Theorie ergreifbar. en-copyright= kn-copyright= en-aut-name=OtiYukio en-aut-sei=Oti en-aut-mei=Yukio kn-aut-name=越智幸雄 kn-aut-sei=越智 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=7-2 article-no= start-page=4093 end-page=4100 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fluctuation of Fatigue Reaction Before and After Laparotomy, and Its Relation to Early Ambulation and Thermal-Bath Part II. Fluctuation of Donaggio-Ochi-Komori (D. O. K.) Reaction in a Few Surgical Cases Before and After Operation kn-title=開腹術前後に於ける疲労反応の消長並に之に及ぼす早期離床，温泉浴の影響 第2編 二，三外科手術前後に於げるドナヂオ・越智・小森反応の消長 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fatigue reaction by the method of D. O. K. was determined on ninety one cases performed major laparotomies, before and after operation for three weeks. Results obtained were as follows. 1) Reaction of D. O. K. determined in uriue, matutinal or preoperative, of various diseases were generally higher than normal, and mostly moderate in the reaction. In the cases with acute inflammation it was significantly elevated with parallel to the extent and severity of inflammation, On non-inflammatory diseases, it was higher in late stage of stomach cancer, bleeding ulcer and intestinal obstruction, successively stomach cancer resected, peptic ulcer with complication of stenosis, cholelithiasis in order. It was lowest and minimum in the cases of uncomplicating ulcer. 2) In the postoperative course, the level of D. O. K was markedly increased in general within one to three days after operation, gradually decreased later until normal on the seventh day, and below normal for two to three weeks until recovery. In the case of stomach cancer resected, the decrease was retarded as compared with that in the case of uncomplicating ulcer and not become normal even after three weeks. The decreasing rate was gradual in the case of acute inflammation, especially in the severe, and not returned to normal even after three weeks. In acute simple appendicitis, though, the level became normal within seven days after operation. 3) In the cases with postoperative complications urinary D. O. K. was increased and showed retarded restoration of the level. 4) From the results obtained above, it was concluded that determination of D. O. K. level in matutinal urine before and after operation was valuable for reading the grade of operative procedure, course of postoperative recovery and the prognosis. en-copyright= kn-copyright= en-aut-name=NakaharaYasuhiro en-aut-sei=Nakahara en-aut-mei=Yasuhiro kn-aut-name=仲原泰博 kn-aut-sei=仲原 kn-aut-mei=泰博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所外科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=発熱病態モデルを用いたアミノフィリン誘発痙攣に関する薬理学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OchiRika en-aut-sei=Ochi en-aut-mei=Rika kn-aut-name=越智理香 kn-aut-sei=越智 kn-aut-mei=理香 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue= article-no= start-page=39 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An evaluation of pancreatographic findings in the differential diagnosis of chronic pancreatitis and pancreatic cancer kn-title=慢性膵炎と膵癌の鑑別診断―分枝像による検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=In an attempt to evaluate the pancreatographic findings, particularly of the pancreatic duct branches, in the differrential diagnosis of chronic pancreatitis and Pancreatic cancer, twenty seven post mortem pancreases were subjected to retrograde pancreatography and histological examination. The materials consist of 15 cases with chronic pancreatitis and 12 cases with pancreatic cancer. The results obtained are as follows. 1) In cases with chronic pancreatitis, abnormal findindings such as irregular dilatation, straightening-hardening, narrowing-stenosis of the pancreatic duct branches were more common. 2) Incases with pancreatic cancer, abnormal findings such as diminishing, irregular dilatation, narrowing-stenosis of the pancreatic duct branches were more common. 3) Abnormal findings in cases with chronic pancreatitis reveled the dendency of diffuse expansion, on the other hand, in case with pancreatic cancer revealed the tendency of localized expansion. 4) When the fine and clear pancreatography was obtained, it was possible to predict the presence of chronic inflammation or tumor cell infiltration from above findings and tendencies. On the contrary, in cases with localized, severe chronic pancreatitis and in cases with complicated, it was difficult to differentiate the pancreatic cancer from chronic pancreatitis. en-copyright= kn-copyright= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=3 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=4 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=5 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue= article-no= start-page=45 end-page=52 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19850330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Endoscopic diagosis of gastric malignant lymphoma kn-title=胃悪性リンパ腫の内視鏡診断 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To delineate the pitfalls and counter-measures in the endoscopic diagnosis of gastric malignant lymphoma (GML), reviewed were 32 cases of primary GML and 16 cases of systemic ML with gastric involvement (secondary GML). 1) Accurate diagnosis of GML had been made in only 13 cases of primary GML ; 18 cases had been diagnosed of gastric cancer (GC); the remaining one of benign ulcer (BU). Review of the endoscopic films, however, revealed more than two of the three findings characteristic, but not pathognomomic, of GML in 84 percent. This result indicates that possibility of GML must be kept in mind in the differential diagnosis of malignant lesions despite its rarity, because endoscopists tend to be predisposed with an impression of GC. 2) Follow-up examinations made in nine cases of primary GML revealed marked changes in endoscopic findings in three cases : healing of an ulcer lesion in one case, healing of an ulcer lesion on an unchanged tumor in another and enlargement of a tumor in the remaining one. The first case had been followed up for two years with an impression of BU. This result indicates that improvement of ulcer does not necessarily rule out GML because it can show "malignant cycle" just as GC. 3) Endoscopic biopsy performed in 30 cases of primary GML had led to accurate diagnosis in only 16 cases and erroneous diagnosis of GC in five and no malignancy in nine. Review of the cases revealed the importance of having suspicion of GML at first from endoscopic findings, because it can lead to an increase of the number of biopsy specimens, careful selection of biopsy sites, careful use of biopsy instruments to obtain good specimens and closer contact with pathologists. 4) Prospective studies on systemic ML revealed gastric involvement in 17 percent. Examinations of the GI tract, especially of the stomach is one of the important steps for staging of systemic ML and deciding therapeutic modalities. 5) It is extremely difficult to diffierentate primary GML and secondary GML from endoscopic findings alone, although there are a few findings characteristic of the latter. en-copyright= kn-copyright= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=YasuokaMasatoshi en-aut-sei=Yasuoka en-aut-mei=Masatoshi kn-aut-name=安岡正敏 kn-aut-sei=安岡 kn-aut-mei=正敏 aut-affil-num=3 ORCID= en-aut-name=OkaHiroo en-aut-sei=Oka en-aut-mei=Hiroo kn-aut-name=岡浩郎 kn-aut-sei=岡 kn-aut-mei=浩郎 aut-affil-num=4 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=5 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=6 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=7 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=8 ORCID= en-aut-name=OhnoshiTaisuke en-aut-sei=Ohnoshi en-aut-mei=Taisuke kn-aut-name=大熨泰亮 kn-aut-sei=大熨 kn-aut-mei=泰亮 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=3 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=4 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=5 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=6 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=7 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=8 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=9 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=100 end-page=102 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analytic study on colon examination for the past three years. kn-title=当院における大腸検査の検討 ―過去3年間のデータの分析― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=1 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属三朝分院放射線室 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設 END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=83 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Classification and concepts of pancreatitis kn-title=膵炎の分類 ―その変遷と最近の考え方― en-subtitle= kn-subtitle= en-abstract=The present paper is a review of the historical changes in the classification and concept of pancreatitis. The Marseille classification and concept had enjoyed its international popularity for more than 20 years since it was adopted at the first Marseille symposium in 1962. However, the recent advancement in the study of the pancreas led to the attempts to revise the classification and concept of pancreatitis ： International Symposium in Cambridge in 1983, Second International Symposium in Marseille in 1984 and Symposium at the International Congress of Gastroenterology in Rome in 1988. As one of us was invited to the last two symposia, we described the details of the revised classification and concept of Marseille (1984) and of Marseille-Rome (1988) ; then, we described the similarities and differences between the Cambridge classification, the revised Marseille classification and the Marseille-Rome classification. Finally we summarized the subjects to be further investigated to make better classification of pancreatitis in the future. kn-abstract=膵炎の分類は膵臓研究の進歩とともに変遷を重ねたが，ここ20年間はマルセイユ分類（1963年）が国際的に広く用いられてきた。しかし最近，膵検査法の進歩と膵研究の知見の蓄積を背景にして，ケンブリッジ（1983年），マルセイユ（1984年），およびローマ（1988年）において分類の改訂を目的に国際シンポジウムが開催され，それぞれに新しい膵炎の分類が提案された。各分類には多くの共通点が見られるが重要な相違点もある。各分類を十分に理解していないとしばらくは混乱に陥ることが危惧される。幸い筆者の1人はこれらのシンポジウムに招待され参加する機会を得たので，成文の背景にある討議を詳しく紹介し，各分類を比較しながらその特徴を述べた。それとともに将来理想的な分類を完成するために今後検討すべき課題をも指摘した。そして，これら分類の当面の利用法に関する筆者らの提案を述べた。 en-copyright= kn-copyright= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=1 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=4 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=5 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=6 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=膵炎 kn-keyword=膵炎 en-keyword=分類 (Classification and concepts of pancreatitis) kn-keyword=分類 (Classification and concepts of pancreatitis) en-keyword=急性膵炎 (Acute pancreatitis) kn-keyword=急性膵炎 (Acute pancreatitis) en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=76 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Interstitial matrix components in relation to the pathogenesis of fibrosis kn-title=細胞間マトリックスの構成成分と線維化 en-subtitle= kn-subtitle= en-abstract=Increasing numbers of patients with chronic pancreatitis have been reported all over the world, including Japan. Pathogenesis of chronic pancreatitis has remained to be revealed and the early detection has remaind difficult despite extensive investigations. Interstitial fibrosis forms one of the most important histopathological features of chronic pancreatitis along with loss of parenchyma and irregular dilatation of the ducts and ductules. However, only a limited numbers of reports have been pubiished on the pathogenetic mechanisms of interstitial fibrosis of the pancres, because tissue materials are not easily accessible and blood samples can hardly reflect the fibrotic process of the pancreas unlike the case of the iiver. Our Preliminary studies revealed that biochemical and immunochemical analysis of pure pancreatic juice, such as determination of collagen, hexosamine, fibronectin and proline hydroxylase, might reflect the fibrotic process of the pancreas. The results led us to review the earlier reports on inter-cellular matrix in relation to the formation of fibrosis to find suitable markers to be evaluated in the future systematic investigations. The review revealed that pure pancreatic juice should be analyzed for collagen, types of collagen, hexosamine, dermatan sulfate, fibronectin, larninin, proline hydroxylase, collagenase and cathepsin B(1). kn-abstract=慢性膵炎の症例は近年増加の一途をたどっており，その発症機序と病態の解明および対策の確立が急がれている。慢性膵炎の重要な所見の一つである膵間質線維化の発生機序の解明および早期発見法の確立は重要な課題であるが，従来の知見は断片的にすぎない。そこで，筆者らは膵線維化の系統的な研究を始めるにあたって，細胞間マトリックスの構成成分と線維化に関する従来の知見および今後の課題を整理した。細胞間マトリックスのうちでも特にコラーゲン，グリコサミノグリカン，フィブロネクチンをとりあげ，その構造と機能および組織の線維化形成における役割について文献的考察を行った。今後，膵組織および膵液中のプロリンハイドロキシラーゼ，コラーゲンとその型別分布および各型コラーゲンの比，ヘキソサミン，デルマタン硫酸，フィブロネクチン，ラミニンを検討することが重要と思われた。 en-copyright= kn-copyright= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=5 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=6 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=7 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=膵の線維化 (Interstitial fibrosis of the pancreas) kn-keyword=膵の線維化 (Interstitial fibrosis of the pancreas) en-keyword=膵間質成分 (Interstitial matrix of the pancreas) kn-keyword=膵間質成分 (Interstitial matrix of the pancreas) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=39 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical evaluation of co-examination by sigmoidoscopy and barium enema study for early diagnosis of colon cancer kn-title=大腸癌早期診断による注腸・内視鏡同日併用法 ―診断能および検査前日食の検討― en-subtitle= kn-subtitle= en-abstract=The present study was performed (1) to evaluate the validity of co-examination by sigmoidoscopy and barium enema study for the early diagnosis of colon cancer and (2) to find the most suitable preparation method for the co-examination. The co-examination was performed on 94 patients : those with abdominal symptoms and signs suggestive of colonic diseases : those with positive occult blood test in stool : or those asking for the routine examination of the colon. The examination revealed 5 cases of colon cancer (2 with early cancer and 3 with advanced cancer) and 26 eases (32 lesions) with colon polyp. The high detection rate of colonic neoplasms, especially of minute lesions, along with the high rate of early lesions among cancers suggested the validity of the co-examination method for the early diagnosis of colon cancer. The method was not time-consuming and not demanding for both patients and doctors, but was effective in detecting minute lesions by allowing a doublecheck in the high-risk recto-sigmpid region ; in addition, the upper colon could be examined by X-ray. The comparative studies on the currently popular Preparation method (modified Brown's method) and a new method with retort foods (Sankenclean, Sanwa Kagaku Kenkyusho Co., Ltd) revealed that the latter was significantly more effective in cleaning colon lumen and visualizing fine network pattern of the colonic mucosa. In addition, the patients were more satisfied with the taste of the latter. kn-abstract=注腸・内視鏡同日併用法の大腸早期癌診断における有用性の検討，その診断能向上のための検査前日食改善を目的に，同法を施行した94例の診断能，従来のBrown変法に準じた献立食とレトルト食（サンケンクリン）とのX線画像の質，内視鏡時の残渣の程度，被検者への味のアンケートを分析した。発見大腸腫瘍は癌5例（早期癌2例，進行癌3例），ポリープ26例32病変である。早期癌はともにポリープの形態をとり，注腸，内視鏡とも病変を指摘できた。病変の好発部位である直腸・S状結腸で注腸・内視鏡によるダブルチェックができる。前日食の検討ではレトルト食が従来の献立食と比し，注腸・内視鏡ともに優れた腸内洗浄能を有し，味のアンケートからも劣ることはなかった。大腸癌早期発見の2次スクリーニングとして，レトルト食を前日食とする同法の有用性が示された。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=7 ORCID= en-aut-name=NakaiMutsurou en-aut-sei=Nakai en-aut-mei=Mutsurou kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=8 ORCID= en-aut-name=HayashimotoKanae en-aut-sei=Hayashimoto en-aut-mei=Kanae kn-aut-name=林本加奈枝 kn-aut-sei=林本 kn-aut-mei=加奈枝 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=大腸早期癌 (Ealry diagnosis of colon cancer) kn-keyword=大腸早期癌 (Ealry diagnosis of colon cancer) en-keyword=注腸・内視鏡同日併用法 (Co-examination by sigmoidoscopy and barium enema study) kn-keyword=注腸・内視鏡同日併用法 (Co-examination by sigmoidoscopy and barium enema study) en-keyword=大腸検査前処置 (Preparation for colon examination) kn-keyword=大腸検査前処置 (Preparation for colon examination) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=1 end-page=5 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of long-term daily intake of thermal water on gastric mucosal blood flow kn-title=胃粘膜血流に及ぼす温泉水の効果 −長期連日飲泉の効果− en-subtitle= kn-subtitle= en-abstract=Effect of long-term oral intake of thermal water on gastric mucosal blood flow was evaluated, using an endoscopic organ reflex spectrophotometry together along with an Olympus XQ-10 forward viewing gastro-fiberscope． Three healthy volunteers and nine patients with gastric diseases in remission (six with healed gastric ulcer and three with chronic gastritis) were put on a 2-week treatment with daily oral intake of Misasa thermal water (38 to 42 ℃, 200m?, two times a day between meals). Gastric mucosal blood flow was measured just before and after the treatment period at three spots of the stomach (lesser curvature of the pylorus, antrum and angle) : Life style and drugs were unchanged during the period. Following results were obtained : (1) Pre-and post-treatment gastric mucosal blood flow (IHb) was 95.0±18.0, and 98.2±15.3 at the pylorus, respectively ; 104.8±16.9 and 110.8±12.8 at the antrum, respectively ; 116.1±20.4 and 118.7±18.5 at the angle, respectively. (2) However, Evaluation of each individual case showed that the post-treatment values were　higher than the pretreatment ones in 75 % of patients at the pylorus and in 67 % of patients at the antrum and angle, respectively. (3) Student's paired t-test showed that the post-treatment increase in blood flow was statistically significant (p<0.05) only at the antrum． These results suggest that an improvement in gastric mucosal blood flow, along with an improvement in gastric secretion and motility, is also contributory to the favorable therapeutic results of spa-drink in chronic gastric diseases. Further studies are in progress to reveal (1) the clinical significance of the improvement in gastric mucosial blood flow, such asacceleration of healing and maintenance of remission, and (2) the characteristics of patients who are likely to show favorable response to the treatment． kn-abstract=内視鏡（オリンパス製XQ−10胃ファイバースコープ）と臓器反射スペクトル法を応用して，2週間連日の飲泉が胃粘膜血流におよぼす効果を検討した。健常者3名および胃疾患患者9名（治癒期にある胃潰瘍の患者6名と慢性胃炎の患者3名）を対象とした。当院飲泉場の温泉水による2週間連日の飲泉を行ない，2週間の飲泉の前後において，胃の3箇所（胃幽門部小弯，前庭部小弯，胃角部小弯）で胃粘膜血流を測定した。その結果，胃前庭部小弯では胃粘膜血流の有意の増加を認めた。しかし胃全体としては有意差を検出出来なかった。個々の症例について検討すると、飲泉後で胃の3箇所すべてにおいて血流が増加したケースが頻度多く認められ，飲泉の有効性が示唆された。従来から認められてきた慢性胃腸疾患に対する飲泉の効果には，胃粘膜血流の改善による要因も加わっている可能性が考えられる。 en-copyright= kn-copyright= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=2 ORCID= en-aut-name=MatumotoShuji en-aut-sei=Matumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=4 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=飲泉療法 (Spa-drink therapy) kn-keyword=飲泉療法 (Spa-drink therapy) en-keyword=胃粘膜血流 (Gastric mucosal blood flow) kn-keyword=胃粘膜血流 (Gastric mucosal blood flow) en-keyword=臓器反射スペクトル法 (Organ reflex spectrophotometry) kn-keyword=臓器反射スペクトル法 (Organ reflex spectrophotometry) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=83 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=トランスフェリンを介する鉄の細胞内取り込み機序 ―特に肝細胞への取り込みにおける内皮細胞の関与について― kn-title=Transferrin-Mediated Cellular Iron Uptake -Special Implication of Endothelium in Hepatic Iron Uptake- en-subtitle= kn-subtitle= en-abstract=トランスフェリン（Tf）は鉄代謝において重要な役割を担っている。鉄を必要とする細胞の表面には，Tfの特異的受容体が存在し，Ffは受容体との結合に引き続いて，coated　pitsとcoated　vesiclesを介して細胞内に取り込まれる（internalization）。Vesicle内での急速なpHの低下にともない，鉄はTfから分離し，細胞内で分画される。一方，鉄を失ったTf（アポTf）は受容体と結合したまま細胞表面にもどり，中性のpHのもとで受容体から解離する。最近の細胞・分子生物学の進歩，遺伝子クローニング，ならびにモノクローナル抗体の開発により，分子レベルで鉄代謝経路が解明されつつある。今回，これまでの主要な知見をまとめ，特に，最近筆者らの研究により明らかとなった，肝の鉄代謝における内皮細胞の役割について考察した。 kn-abstract=Transferrin (Tf) is thought to play a pivotal role in iron metabolism of various kinds of cells. Tf has specific receptors on the surface of the cells that require iron. Tf-receptor binding is followed by internalization through a system of coated pits and vesicles. The rapid decline of pH of these vesicles leads to the release and sequestration of iron by the cell. Apotransferrin-receptor complex returns to the cell surface, where under neutral pH conditions, apotransferrin is dissociated from the receptor. Recent advances in cellular and molecular biology, gene cloning and monoclonal antibody technique have elucidated many features of these processes at a molecular level. These advances are briefly reviewed, and particularly, our own observations concerning endothelial mediation of uptake of Tf by hepatocytes are discussed. en-copyright= kn-copyright= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=1 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MehdiTavassoli en-aut-sei=Mehdi en-aut-mei=Tavassoli kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=ミシシッピ州立大学医学部 en-keyword=Iron uptake (鉄の細胞内取り込み) kn-keyword=Iron uptake (鉄の細胞内取り込み) en-keyword=Transferrin (トランスフェリン) kn-keyword=Transferrin (トランスフェリン) en-keyword=Receptor-Mediated Endocytosis kn-keyword=Receptor-Mediated Endocytosis en-keyword=Desialation (脱シアル化) kn-keyword=Desialation (脱シアル化) en-keyword=Endothelium (内皮細胞) kn-keyword=Endothelium (内皮細胞) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=68 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Etiology and pathogenesis of chronic pancreatitis kn-title=慢性膵炎の成因，病態と発生機序 en-subtitle= kn-subtitle= en-abstract=Main etiologies of chronic pancreatitis (CP)include "alcoholic" (60%), "idiopathic" (27%)and "biliary" (8%). Clinico-pathological features comprise intractable abdominal pain, maldigestion secodary to exocrine pancreatic insufficiency and diabetes secondary to endocrine pancreatic insufficiency. Death is not infrequent during follow-up. Pathogenesis and evolution of alcoholic CP were discussed in connection with "Big Duct Theory", "Toxic-Metabolic Theory", and "Protein Plug Theory". Diet and congenital predisposition as well as alcoholic comsumption play important roles in various combinations in the pathogenesis and evolution of CP. Important initial lesins of alcoholic CP are probably : (1) pancreatic ductular Obstruction due to proetin plug formation resulting from increased protein and mucoprotein concentration in pancreatic juice ; (2) damage and sloughing of ductular epithelia caused by protein plugs or by a direct toxic effect of ethanol secreted into pancreatic juice, and subsequent ductular stenosis and peri-ductular fibrosis. Parenchymal destruction with interstitial fibrosis is induced upstream to the ductular lesions. These, structural abnormalities and multiple biochemical abnormalities of pancreatic juice further lead to self-perpetuating evolution. Anti-acinar-cell antibody, anti-duet-cell antibody and immune complex in serum are most probably mere epiphenomena and not the causes of CP. kn-abstract=慢性膵炎の成因の主たるものは，アルコール性，特発性，胆石性である。病態面では，社会的・家庭的にもっとも責任が重い壮年期に頑固な疼痛，消化吸収障害，二次性糖尿病のために生活の質が低下することが問題になる。経過中に併発してくる膵およびそのほかの臓器の癌，および糖尿病の合併症による死亡も少なくない。アルコール性慢性膵炎の初期病変の発生機序としては，@膵過分泌の結果として細膵管内に形成される蛋白栓による膵液流出障害と，A蛋白栓あるいはアルコールの直接障害作用による細膵管上皮の損傷，およびその結果生じる膵管狭窄による膵液流出障害が注目されている。膵液流出障害はその上流域に実質細胞の破壊と間質の線維化をおこす。膵液には多くの生化学的異常が認められ，いったん発生した膵管の構造異常とあいまって慢性膵炎進展の原因となる。素因および栄養のアンバランスは発症，進展の促進因子となる。発症を予防し，進展を阻止する手段を開発するためには素因および飲酒・食事を含む環境因子の解析が今後の重要な課題である。 en-copyright= kn-copyright= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=1 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=6 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=成因 (Etiology) kn-keyword=成因 (Etiology) en-keyword=発生機序 (Pathogenesis) kn-keyword=発生機序 (Pathogenesis) END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=12 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of spa-drink therapy on exocrine pancreatic function kn-title=膵外分泌機能におよぼす飲泉の効果 en-subtitle= kn-subtitle= en-abstract=The effect of spa-drink therapy (Misasa hot spring) on exocrine pancreatic function was studied on 18 patients after their physical and psychological conditions were stabilized about two weeks following hospitalization. Patients were randomly divided into two groups : eight patients into a control group (continuance of spa-bathing) and 10 patients into a spa-drink therapy group (continuance of spa-bathing plus commencement of spa-drink therapy). Spa-drink therapy refers to drinking 200m? of warm spa-water (42℃) two times a day : between meals in the morning and in the afternoon. Exocrine pancreatic function was evaluated by fecal chymotrypsin activity, using a colorimetric method (Boehringer-Mannheim). Following results were obtained : 1) With 2-week's spa-drink therapy, fecal chymotrypsin activity was significantly enhanced in 40 % of the patients, while none of the controls showed an increase in fecal chymotrypsin activity. 2) Fecal chymotrypsin activity at the time of 4 weeks was similar to that obtained at the time of 2 weeks in both groups. In conclusion, spa-drink therapy for 2 weeks was effective for the enhancement of exocrine pancreatic function. kn-abstract=膵外分泌機能におよぼす飲泉（三朝温泉水）の効果を飲泉群および非飲泉群を対象として検討した。膵外分泌機能検査法としては，糞便中キモトリプシン活性比色測定法（モノテストカイモトリプシン）を用いた。その結果，糞便中キモトリプシン活性は，飲泉開始2週後に40　％　の患者で上昇し，4週後は2週後と変わらなかった。以上より，2週間の飲泉は膵外分泌機能を改善させる効果があることがわかった。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=6 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=7 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=8 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=糞便中キモトリプシン活性 (Fecal chymotrypsin activity) kn-keyword=糞便中キモトリプシン活性 (Fecal chymotrypsin activity) en-keyword=飲泉療法 (Spa-drink therapy) kn-keyword=飲泉療法 (Spa-drink therapy) en-keyword=膵外分泌機能 (Pancreatic exocrine function) kn-keyword=膵外分泌機能 (Pancreatic exocrine function) en-keyword=膵 (Pancreas) kn-keyword=膵 (Pancreas) en-keyword=酵素 (Enzyme) kn-keyword=酵素 (Enzyme) END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Short term effect of spa-water on gastric mucosal blood flow kn-title=胃粘膜血流に及ぼす温泉水の効果 en-subtitle= kn-subtitle= en-abstract=Short-term effects of spa-drink therapy on gastric mucosal blood flow were evaluated by an endoscopic organ reflex spectrophotometry, using Olympus XQ-10. Thirty-four subjects were randomly divided into three groups : 10 subjects for warm spa-water (40±C) infusion group, 10 subjects for warm tap-water infusion group, and 14 subjects for warm air infusion group. Intragastric infusion of water or air was performed through the fiberscopic infusion channel. Gastric mucosal blood flow was determined just before and 10 min after the infusion on the three points of gastric mucosa : lesser curvature of the angle, the antrum and the pylorus. Following results were obtained : 1) Spa-water exerted a beneficial effect on gastric mucosal blood flow as compared to air. The difference was statistically significant on all of the three points. 2) Spa-water tended to exert a beneficial effect on gastric mucosal blood flow as compared to tap-water. The difference, however, was significant only on the mucosa of the gastric antrum. In conclusion, it was suggested that spa-drink therapy was useful for the treatment of chronic gastritis and gastric ulcer in which impairment of gastric mucosal blood flow plays an important pathogenetic role. Studies on the long-term effects of spa-drink therapy on the gastric mucosal blood flow are now in progress. kn-abstract=臓器反射スペクトル法と内視鏡を併用して胃粘膜血流を測定し，当院温泉水飲用の消化機能に対する基礎的検討を胃粘膜血流を指標に行なった。温泉水の対照として空気と白湯を選び3群に分け検討した。その結果，温泉水は空気に比し胃粘膜血流を増加させる作用を有していることが示唆された。また温泉水は部分的ではあるが白湯にくらべても胃粘膜血流を増加させる作用があることが示唆された。よって飲泉療法の消化器疾患に対する臨床的有用性が胃粘膜血流の面からもうかがわれた。 en-copyright= kn-copyright= en-aut-name=TanakaJuntarou en-aut-sei=Tanaka en-aut-mei=Juntarou kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=MatumotoShuuji en-aut-sei=Matumoto en-aut-mei=Shuuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=3 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=4 ORCID= en-aut-name=OchiKouji en-aut-sei=Ochi en-aut-mei=Kouji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=5 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=6 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=7 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 en-keyword=飲泉療法 (Spa-drink therapy) kn-keyword=飲泉療法 (Spa-drink therapy) en-keyword=消化器機能 (Digestive function) kn-keyword=消化器機能 (Digestive function) en-keyword=胃粘膜血流 (Gastric mucosal blood flow) kn-keyword=胃粘膜血流 (Gastric mucosal blood flow) en-keyword=臓器反射スペクトル法 (Organ reflex spectrophotometry) kn-keyword=臓器反射スペクトル法 (Organ reflex spectrophotometry) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=29 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis of chronic pancreatitis kn-title=慢性膵炎の診断 ―画像診断と機能検査の併用による― en-subtitle= kn-subtitle= en-abstract=Endoscopic retrograde cholangiopancreatography (ERCP), ultrasonography (US), computed tomography (CT), exocrine pancreatic function test (EX), endocrine pancreatic function test (EN), and analysis of pure pancreatic juice (PPJ) are currently available for the investigation of pancreatic diseases. The purpose of the present study is to evaluate the roles and preferable combinations of these tests in the diagnosis of chronic pancreatitis and then to propose a way to describe the results of the tests along with diagnosis for a better understanding of the disease process. Comparative studies of imaging, EX and EN led to the following conclusions. 1) imaging procedures (ERCP, US and CT) are mandatory, partly because they were frequently the test that showed diagnostic changes and partly because they often gave key information for operative treatment. Among the imaging procedures, ERCP combined with US and/or CT is mandatory because these combinations alone can reveal detailes of structural changes attendant on chronic pancreatitis. 2) EX is also mandatory, because it was occasionally the only test that showed diagnostic changes and partly because it often gave important information for medical treatment. 3) EN is also important, not because it was indispensable for detecting chronic pancreatitis, but because it often gave important information for medical treatment. For btter understanding of the disease process as well as diagnosis, we propose, as suggested by Seligson, that the test used for the establishment of the diagnosis and the degree as well as extent of abnormalities. An example is "Calcified chronic pancreatitis, alcoholic, diffuse, ERCP-3, US-2, CT-3, EX-2, EN-1, Lf(+)". This attitude will lead to a more rational approach to both diagnosis and treatment. kn-abstract=近年，各種膵疾患に対する検査法の発達には目を見張るものがあるが，実際の運用にあたっては各検査法の適応，限界，組合わせおよび実施する順序等に迷うことが少なくない。本研究では，最近我々が経験した慢性膵炎T群116例の診断過程を振り返ることにより，慢性膵炎の診断における理想的な検査法の組合わせとそれぞれの役割を検討し，同時に診断名のみならず病態と病期が容易に理解できる表現方法を提案した。画像診断法，膵外分泌機能検査法（EX），膵内分泌機能検査法（EN）を比較検討し，以下の結果を得た。@画像診断法は必須である。A内視鏡的逆行性膵胆管造影（ERCP）を軸とした腹部超音波検査（US）あるいは腹部CTスキャン（CT）の組合わせは欠くことができない。BEXもまた必須の検査法である。CENは慢性膵炎の診断に必要不可欠ではないが，治療方針を決めるうえで重要である。D純粋膵液（PPJ）の生化学的検査と組織化学的検査は膵炎の診断と病態生理の解明に重要である。EPPJ中の細胞診は慢性膵炎に合併した膵癌の検索に有用である。F以下に示すような診断の記載方法を提案した。"Calcified chronic pancreatitis, alcoholic, diffuse,　ERCP-3, US-2, CT-3, EX-2, EN-1, Lf(＋)"。 en-copyright= kn-copyright= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=YoshidaMitsuo en-aut-sei=Yoshida en-aut-mei=Mitsuo kn-aut-name=吉田光雄 kn-aut-sei=吉田 kn-aut-mei=光雄 aut-affil-num=6 ORCID= en-aut-name=OkaHiroo en-aut-sei=Oka en-aut-mei=Hiroo kn-aut-name=岡浩郎 kn-aut-sei=岡 kn-aut-mei=浩郎 aut-affil-num=7 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=画像診断 (imaging diagnosis) kn-keyword=画像診断 (imaging diagnosis) en-keyword=PS試験 (pure pancreatic juice) kn-keyword=PS試験 (pure pancreatic juice) en-keyword=純粋膵液(PPJ) (Pancreozymin-Secretin test) kn-keyword=純粋膵液(PPJ) (Pancreozymin-Secretin test) en-keyword=内視鏡的逆行性膵胆管造影(ERCP) (endoscopic retrograde cholangiopancreatography (ERCP)) kn-keyword=内視鏡的逆行性膵胆管造影(ERCP) (endoscopic retrograde cholangiopancreatography (ERCP)) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=24 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of aging on pancreatic exocrine function -Aging and fecal chymotrypsin activity- kn-title=膵外分泌機能に及ぼす加齢の影響 ―加齢と糞便中キモトリプシン活性― en-subtitle= kn-subtitle= en-abstract=To examine the effect of aging on the pancreatic exocrine function, fecal chymotrypsin activity (FCA) was measured by the photometric method in 43 healthy controls, 39 controls in an old-age home and 41 patients with non-pancreatic diseases. Following conclusions were obtained. 1) Pancreatic exocrine function showed a significant decrease with aging as indicated by the present prospective study : @ a significantly lower FCA in the B group of 22 healthy controls (≧ 60 years of age) than the A group of 21 healthy controls (< 60 years of ago) ; A significant correlationship between aging and FCA in the 43 healthy controls and also in the 41 patients with non-pancreatic diseases. 2) FCA in controls in an old-age home was especially low. Presumably it was due to their far-advanced aging. 3) The calculated lower limit of normal in FCA was 14.5U/g. However, the diagnosis of pancreatic diseases should not be coined solely on the basis of decreased FCA value. kn-abstract=膵外分泌機能に及ぼす加齢の影響を検討する目的で，健常人43名，非膵疾患患者41名，老人ホーム入居者39名を対象として比色法により糞便中キモトリプシン活性（FCA）を測定し，以下の結論を得た。1）FCAは逐齢的に低下し，60歳以上は60歳未満より有意の低値を示した。しかし，分布図のretrospectiveな検討からは，膵外分泌機能の低下は，実際には65〜70歳あたりから明らかになることが示唆された。2）FCAの正常下限値を14.5U/gに定めたが，高齢者の診療にあたってはこの正常値のみを根拠にして疾病の有無を判定すべきではない。3）老人ホーム入居者のFCAは特に低値を取ったがその主要因は高齢者が多いためと考えられた。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=6 ORCID= en-aut-name=YoshidaMitsuo en-aut-sei=Yoshida en-aut-mei=Mitsuo kn-aut-name=吉田光雄 kn-aut-sei=吉田 kn-aut-mei=光雄 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=糞便中キモトリプシン活性 (Fecal chymotrypsin activity) kn-keyword=糞便中キモトリプシン活性 (Fecal chymotrypsin activity) en-keyword=加齢 (Aging) kn-keyword=加齢 (Aging) en-keyword=膵外分泌機能 (Pancreatic exocrine function) kn-keyword=膵外分泌機能 (Pancreatic exocrine function) en-keyword=膵 (Pancreas) kn-keyword=膵 (Pancreas) en-keyword=酵素 (Enzyme) kn-keyword=酵素 (Enzyme) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=84 end-page=86 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Report on monthly meeting for diabetic patients in Misasa Branch Hospital kn-title=糖尿病教室の報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakumaMasae en-aut-sei=Takuma en-aut-mei=Masae kn-aut-name=田熊正栄 kn-aut-sei=田熊 kn-aut-mei=正栄 aut-affil-num=1 ORCID= en-aut-name=MasuiEtsuko en-aut-sei=Masui en-aut-mei=Etsuko kn-aut-name=増井悦子 kn-aut-sei=増井 kn-aut-mei=悦子 aut-affil-num=2 ORCID= en-aut-name=HayashimotoKanae en-aut-sei=Hayashimoto en-aut-mei=Kanae kn-aut-name=林本加奈枝 kn-aut-sei=林本 kn-aut-mei=加奈枝 aut-affil-num=3 ORCID= en-aut-name=AsaumiNoboru en-aut-sei=Asaumi en-aut-mei=Noboru kn-aut-name=浅海昇 kn-aut-sei=浅海 kn-aut-mei=昇 aut-affil-num=4 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=5 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=6 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病等分野 affil-num=7 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病等分野 END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=74 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical evaluation of an endoscopic image filing system, Olympus SDF-3 kn-title=電子内視鏡ファイリングシステムSDF-3の使用経験 en-subtitle= kn-subtitle= en-abstract=Olympus SDF-3, an endoscopic image　filing system using an electronic endoscope in　conjunction with a personal computer and an　optical disk, has been recently developed. We evaluated the usefulness of this filing system with 449 cases of gastroduodenal endoscopy. As a result, we have found that this filing system has following advantages : (1) one can review endoscopic images immediately after endoscopic examinations ; (2) previously documented endoscopic image can be searched and reviewed in a short time ; (3) statistical analysis of documented cases is facilitated. However, it has some disadvantages as well to be improved : (1) quality of endoscopic images is deteriorated in the process of filing ; (2) putting patients' data into the filing system is time-consuming ; (3) frequent cleaning of an optic disk is required. This endoscopic image filing system needs to be further developed and refined. kn-abstract=光ディスクとパーソナルコンピュータを組み合わせた内視鏡画像ファイリングシステムは電子内視鏡の画像の保存･管理,検索･再生などに威力を発揮する｡今回,われわれはオリンパス社製内視鏡ファイリングシステムSDF-3を使用する機会を得たので,その有用性や問題点の検討を行った｡有用性としては,@内視鏡画像を検査終了後直ちに再生し,再検討できる,A多数の項目についての検索や統計処理が可能である,B限られたスペース内で大量の画像データの一括保存･管理が可能であるなどが挙げられる｡一方,問題点としては,@内視鏡再生画像は画質が劣化する,A検索機能を十分に活用するにはかなり煩雑な人力操作を必要とする,B光ディスクの清掃が必要であるなどがあげられる｡本内視鏡ファイリングシステムに今後必要な改良点やその展望についても合わせて考案を加えた。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=TanizakiYosiro en-aut-sei=Tanizaki en-aut-mei=Yosiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=画像ファイリングシステム (image filing system) kn-keyword=画像ファイリングシステム (image filing system) en-keyword=電子内視鏡 (electronic endoscope) kn-keyword=電子内視鏡 (electronic endoscope) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=69 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者における細胞性免疫,ガンジダ抗原に対する遅延型反応の抑制 kn-title=Cell-mediated immunity in bronchial asthma. Depressed response towards Candida albicans en-subtitle= kn-subtitle= en-abstract=気管支喘息200例を対象にカンジダに対する即時型および遅延型皮膚反応を観察し,これらの皮膚反応と年令,血清IgE値との関連について検討を加えた｡1. カンジダに対する遅延型皮膚反応は,10〜20才の年齢層および61才以上の年齢層の症例において,その陽性率の低下が観察された｡そして,10〜20才の年齢層と41〜50才の年齢層の症例では,両者間で陽性率の有意の差が見られた(p<0.001)。2. カンジダに対する遅延型皮膚反応の陽性率は,血清IgE値が低い(0〜100 IU/ml)症例において最も高く,一方血清IgE値が高い(1001IU/ml以上)症例において最も低いという傾向が見られた｡これらの結果は,カンジダに対する細胞性免疫は,10〜20才の年齢層ではアトピーと,また61才以上の年齢層では加齢と関連して抑制されることを示唆するものと考えられる。 kn-abstract=Delayed cutaneous hypersensitivity towards Candida albicans was examined　in 200 patients with bronchial asthma in relation to patient age and the level of　total IgE. 1. Delayed skin reactivity towards C.albicans was depressed in the patients between the ages of 10 and 20 and in those over the age of 61. A significant difference was present in delayed skin reactivity between the groups of 10-20 and 41-50 years old. 2. The frequency of the patients with positive delayed skin reactivity towards C.albicans was the highest in those with low levels of total IgE (0 -100 IU/ml) and the low est in those with high levels of total IgE (over than 1001 IU/ml). The results suggest that cell-mediated immunity towards C.albicans is depressed re lating to atopics in the patients between 10 and 20 and to aging in the patients over 61. en-copyright= kn-copyright= en-aut-name=TanizakiYosiro en-aut-sei=Tanizaki en-aut-mei=Yosiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=cell-mediated immunity (細胞性免疫) kn-keyword=cell-mediated immunity (細胞性免疫) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=atopics (アトピー) kn-keyword=atopics (アトピー) en-keyword=aging (加齢) kn-keyword=aging (加齢) en-keyword=カンジダ kn-keyword=カンジダ END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=65 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagonosis of pancreatic cyst using post-ERCP CT examination. kn-title=ERCP後CTによる膵嚢胞性疾患の診断 en-subtitle= kn-subtitle= en-abstract=Post-ERCP CT (computed tomography (CT) examination performed immediately after endoscopic retrograde cholangiopancreatography) detects the contrast medium injected into the pancreatic duct and cystic lesions at the time of ERCP and, therefore, has the advantage of obtaining information which cannot be obtained by ERCP alone. We have experienced four cases of pancreatic cysts in which post-ERCP CT was useful for diagnosis and in deciding on treatment plans. The post-ERCP CT was proved to be a useful method for examining the site and characteristics of the cysts which communicated with the main pancreatic duct. kn-abstract=ERCP直後にCTを撮影するERCP後CTはERCPの際に膵内に注入された造影剤をCTで検出するため,ERCPでは得られない情報が得られる利点がある｡われわれはERCP後CTが診断や治療方針の決定に有用であった膵嚢胞の4例を経験した｡膵嚢胞では主膵管との連絡,嚢胞の部位,性状診断にERCP後CTは有用な検査法であり,文献的考察を含めて報告した｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoTosinobu en-aut-sei=Seno en-aut-mei=Tosinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=RiazChowdhury kn-aut-sei=Riaz kn-aut-mei=Chowdhury aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=8 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=11 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=12 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学第2内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院 affil-num=9 en-affil= kn-affil=岡山大学三朝分院 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=岡山大学三朝分院 affil-num=13 en-affil= kn-affil=勝山病院外科 en-keyword=ERCP (Endoscopic retrograde cholangiopancreatography) kn-keyword=ERCP (Endoscopic retrograde cholangiopancreatography) en-keyword=CT (Computed tomography) kn-keyword=CT (Computed tomography) en-keyword=膵嚢胞 (pancreatic cyst) kn-keyword=膵嚢胞 (pancreatic cyst) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=39 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=老年者の気管支喘息. アレルギー反応と気道細胞反応 kn-title=Bronchial asthma in the elderly. Relationship to allergic reaction and airway inflammation en-subtitle= kn-subtitle= en-abstract=70才以上の老年者気管支喘息の特徴について,アレルゲンに対する即時型皮膚反応および特異的IgE抗体,換気機能,気管支肺胞洗浄液(BAL)中の細胞成分などにより検討した｡1.アレルゲンに対する即時型皮膚反応および特異的IgE抗体の陽性率は,全般的にかなり低い傾向を示した｡2.換気機能にはかなりのばらつきが見られたが,25例中15例(60%)では,,いずれの換気パラメー ターもかなり高い値を示し,これらの症例の平均FEV(1.0%)は71.3%であった｡3.BALを施行した11例中,% V(25)値の低下とBAL中好中球増多との間に関連の見られた症例は2例のみで,他の9例では% X(25)値の高度な低下にもかかわらず,BAL中の好中球増多は見られなかった｡これらの結果より,老年者気管支喘息では,IgEにmediateされるアレルギー反応は全般的に弱いこと,またBAL液中好中球増多なしに% V(25)値の高度な低下が出現してくることが示された｡ kn-abstract=Clinical features of bronchial asthma in the elderly were analyzed by observlng IgE-mediated allerglc reactions evaluated by immediate skin reaction and specific IgE antibodies to allergens, ventilatory function and cellular composition in bronchoalveolar lavage (BAL) fluid. 1. The frequency of positive immediate skin reaction and positive RAST score to allergens was in general low in the elderly patients over age 70. 2. Ventilatory function was widely variegated, and fifteen cases (60%) of the 25 Subjects showed considerably high values of FEV(l.0%), % PEFR, % MMF, % V(50) and % V(25), and the mean value of FEV(1.0%) in these cases was 71.3%. 3. The decreased value of % V(25) was related to BAL neutrophilia in 2 cases, but any correlation was not found between BAL neutrophilia and decreased value of % V(25) in 9 csese of the eleven subjects who had the BAL examination. The results show that in asthma of elderly patients, IgE-mediated allergic reactions are weak, and that a decreased value of % V(25) can be observed without BAL neutrophilia. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=6 ORCID= en-aut-name=HonkeNaoko en-aut-sei=Honke en-aut-mei=Naoko kn-aut-name=本家尚子 kn-aut-sei=本家 kn-aut-mei=尚子 aut-affil-num=7 ORCID= en-aut-name=KusauraYasuhiro en-aut-sei=Kusaura en-aut-mei=Yasuhiro kn-aut-name=草浦康浩 kn-aut-sei=草浦 kn-aut-mei=康浩 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=10 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=elderly subjects (老年者) kn-keyword=elderly subjects (老年者) en-keyword=lgE-mediated allergic reaction (IgE系反応) kn-keyword=lgE-mediated allergic reaction (IgE系反応) en-keyword=ventilatory function (換気機能) kn-keyword=ventilatory function (換気機能) en-keyword=BAL neutrophilia (BAL好中球) kn-keyword=BAL neutrophilia (BAL好中球) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=43 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=抗原および Ca ionophore A23187 刺激時におけるアトピー型気管支喘息末梢血好塩基球の運動能 kn-title=Difference in motility of basophilic, granulocytes from atopic subjects following antigen- and Ca inophore A23187-stimulation en-subtitle= kn-subtitle= en-abstract=アトピー型気管支喘息末梢血好塩基球を用い,抗原および Ca ionophore A23187 刺激時のヒスタミン遊離およびその形態的変化について比較検討した｡1.抗原刺激時には, Ca ionophore A23187 刺激時に比べ,好塩基球からのヒスタミン遊離および好塩基球数の減少の程度は,より急激でかつ高度であった｡2.好塩基球の形態的変化,すなわち,長経/短経比の増大,限局性顆粒あるいは偽足を有する好塩基球の出現頻度の増加などの運動能の亢進を示唆する好塩基球の形態的変化は, Ca ionophore A23187 に比べ抗原刺激時により高度であった｡一方,平均直径の増大,5個以上の空砲を有する好塩基球の出現頻度の増加などの,むしろ膨化傾向を示唆する好塩基球の形態的変化は,抗原刺激時に比べ, Co ionophore A23187 刺激時により高度であった｡これらの結果より,抗原刺激によるIgE受容体のbridgingが,好塩基球を活性化し,運動能の亢進をひき起こすものと判断された。 kn-abstract=We examined histamine release and morphological changes in basophilic granulocytes from atopic subjects, in response to stimulation with antigen and Ca ionophore A23187. 1. Histamine release and a reduction in the rumber of basophils were more rapid and greater in extent at an early stage of antigen stimulation compared with Ca ionophore A23187 stimulation. 2. Morphological changes in basophils, represented by increased motility, in terms of an increased ratio of short to long axis diameter (L/S ratio), as well as the increased frequency of basophils with localized granules and those with pseudopods, were more often observed antigen stimulation than with Ca ionophore A23187 stimulation. In contrast, morphogical changes in which basophils appeared swollen, showing an increased mean cell diameter and an increased frequency of cells with 5 vacuoles or more were more predominant with Ca ionophore A23187 than with antigen stimulation. The results obtained here show that bridging of IgE receptors is essential to activate basophils and induce increased motility in these cells. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川二郎 kn-aut-sei=中川 kn-aut-mei=二郎 aut-affil-num=7 ORCID= en-aut-name=SodaRyo en-aut-sei=Soda en-aut-mei=Ryo kn-aut-name=宗田良 kn-aut-sei=宗田 kn-aut-mei=良 aut-affil-num=8 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=histamine release (ヒスタミン遊離) kn-keyword=histamine release (ヒスタミン遊離) en-keyword=increased basophil motility (好塩基球の運動能の亢進) kn-keyword=increased basophil motility (好塩基球の運動能の亢進) en-keyword=bridging of IgE receptors (LgE 受容体) kn-keyword=bridging of IgE receptors (LgE 受容体) en-keyword=antigen (抗原) kn-keyword=antigen (抗原) en-keyword=Ca ionophore A23187 kn-keyword=Ca ionophore A23187 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=75 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=老年者気管支喘息における液性および細胞性免疫反応について kn-title=Humoral and cellular immune response in elderly patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息における液性および細胞性免疫反応について,老年者気管支喘息,老年者健常人,および若年者気管支喘息の間で比較検討を行った｡1.まず,液性免疫では,血清IgE値高値,ハウスダストやカンジダに対するIgE抗体陽性などのIgE系反応は,老年者気管支喘息においては明らかに観察されたが,老年者健常人では全く観察されなかった｡血清IgGおよびIgA値には3者間に有意の差は見られなかったが,血清IgMは,若年者喘息に比べ老年者喘息で有意に低い値を示した｡2.ハウスダストやカンジダに対するIgE抗体は老年者喘息において老年者健常人に比べより高い頻度で陽性であったが,一方,ハウスダストに対するIgG(4)抗体は3者聞に有意の差は見られなかった｡また,カンジダに対するIgG(4)抗体は,老年者喘息および健常人において,若年者喘息に比べ有意の高値を示した｡しかし,老年者の喘息と健常人との間には有意の差は見られなかった｡3.PPDによる遅延型皮膚反応は,若年者喘息に比べ老年者喘息において有意の減弱傾向を示した｡これらの結果は,老年者喘息はIgE系反応を有していること,そして,加齢による免疫反応の変化の影響を受けること,を示している｡ kn-abstract=Humoral and cellular immune responses in bronchial asthma were examined by comparing the results of older asthmatics (group OA) with those of older healthy subjects (group OH) and of younger asthmatics (group YA). In humoral immune response, IgE-mediated immune system expressed by elevated serum IgE levels and IgE antibodies for house dust mite (HDm) and/or Candida albicans was clearly found in older asthmatics, while there was no finding showing the presence of IgE-mediated immune response in older healthy subjects. There was no significant difference in levels of serum IgG and IgA among the three groups. However, the serum IgM level was significantly lower in older asthmatics than in younger asthmatics. IgE antibodies to HDm and/or Candida albicans were more frequently found in older asthmatics compared with older healthy subjects. In contrast, IgG(4) antibodies to HDm were not different among the three groups. IgG(4) antibodies to Candida albicans were significantly higher in both older groups than in younger group. However, there was no significant difference between asthmatic and healthy subjects in the elderly. Delayed skin reaction to PPD was significantly more decreased in older asthmatics. These results show that bronchial asthma in the elderly is characterized by the presence of IgE-mediated immune response and by the changes of immune response with aging. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=12 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=13 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=IgE kn-keyword=IgE en-keyword=IgG(4) kn-keyword=IgG(4) en-keyword=Immunoglobulings (免疫グロブリン) kn-keyword=Immunoglobulings (免疫グロブリン) en-keyword=PPD kn-keyword=PPD en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) en-keyword=加齢 kn-keyword=加齢 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=31 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息におけるハウスダストアレルギー. 血清IgE値とIgE抗体価と年齢との関連 kn-title=House dust mite allergy in patients with　bronchial asthma. Serum IgE levels and IgE antibody values in relation to patient age. en-subtitle= kn-subtitle= en-abstract=ハウスダストが原因抗原であるアトピー型気管支喘息50例を対象に,血清IgE値とIgE抗体価を年齢との関連のもとに検討した｡1.IgE抗体価は10-19才の年齢層の症例において最も高く,一方40才以上の症例では全般的に低い傾向が見られた｡2.10-19才の年齢層の症例では,IgE抗体価の高値と同時に血清IgE値も高い値を示したが,40才以上の症例では,IgE抗休価および血清IgE値いずれも10-19才の症例に比べ全般的に低い値を示した｡9才以下の症例では,IgE抗体価の高値にもかかわらず,血清IgE値は比較的低く,500IU/ml以下を示した症例が10例中5例に観察された｡これらの結果は,若年症例では,IgE抗体の産生亢進と総IgEの産生亢進が同時に見られること が多いが,9才以下ではIgE抗体産生亢進に総IgE産生亢進が必ずしもともなわない場合があることを示している｡また,40才以上の症例では,ハウスダストに対する過敏性は有しているものの,IgE抗体価および血清IgEは全般的に低い値を示す傾向が示唆された｡ kn-abstract=Serum IgE levels and IgE antibody values in relation to patient age were examined in 50 patients with house dust mite (HDm) sensitive asthma, 1. IgE antibody values to HDm were highest in patients between the ages of 10 and 19, and the　values generally low in those over the age of 40. 2. High IgE antibody values to HDm　were accompanied by high serum IgE levels in patients between 10 and 19. IgE antibody values and serum IgE levels were in general low in patients over age 40. In patient under　age 9, serum IgE levels were less than 500 IU/ml in 5 of the 10 subjects despite an increased value of IgE antibodies to HDm. These results suggest that an increased　production of IgE antibodies to HDm is usually accompanied by an increased production of total IgE in younger subjects. However, an increase in production of IgE antibodies is not always related to an increase in production of total IgE in patients under age 9. The results also show that production of IgE antibodies to HDm and total IgE is in general low in older patients despite the hyperreactivity to HDm. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=10 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=11 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Serum IgE (血清IgE) kn-keyword=Serum IgE (血清IgE) en-keyword=IgE antibodies (IgE抗体) kn-keyword=IgE antibodies (IgE抗体) en-keyword=house dust mite (ダニ) kn-keyword=house dust mite (ダニ) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=24 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における気道炎症反応の臨床的意義｡慢性閉塞性細気管支炎との比較検討 kn-title=Clinical significance of airway inflammation in bronchcial asthma. Comparison with chronic obstructive bronchiolitis. en-subtitle= kn-subtitle= en-abstract=気管支喘息28例および慢性閉塞性細気管支炎9例を対象に,気道炎症反応の臨床的意義について検討を加えた｡1.気管支肺胞洗浄(BAL)液中の総細胞数は,慢性閉塞性細気管支炎において著明に増加しており(51.0×10(6)),気管支喘息(9.6×10(6))との間に有意の差が見られた｡2.BAL液中マクロファージの頻度は気管支喘息において,慢性閉塞性細気管支炎に比べ有意に高い値を示したが,絶対数での比較では両疾患群間に有意の差は見られなかった｡ 3.BAL液中リンパ球の頻度は,気管支喘息においてやや高い傾向が見られたが,絶対数の比較では慢性閉塞性細気管支炎において有意に高い値であった｡ 4.BAL液中の好中球は,その頻度および絶対数とも慢性閉塞性細気管支炎において著明に増加しており,これは気管支喘息と比べ有意に高い値であった｡ 5.BAL液中好酸球の頻度および絶対数は,気管支喘息においてやや高い値であったが,両疾患群間に有意の差は見られなかった｡以上の結果より,気管支喘息における気道炎症反応は,慢性閉塞性細気管支炎ほど高度ではない ことが明らかにされた。 kn-abstract=Clinical significanoce of airway inflammation was assessed in 28 patients with bronchial asthma, and the results were compared with those in 9 patients with chronic obstructive bronchiolitis (COB). 1. Total cell number in bronchoalveolar lavage(BAL) fluid was markedly increased in patients with COB (51.0×10(6)), which was significantly greater than that in those with bronchial asthma (9.6×10(6) ). 2. The proportion of BAL macrophages was significantly higher in patients with bronchial asthma than in those with COB. However, the, absolute number of BAL macrophages was not significantly different between them. 3. The proportion of BAL lymphocytes was higher in patients with bronchial asthma than in those with COB, but this difference was not signifcant. In contrast, the absolute number of BAL lymphocytes was significantly greater in patients with COB than in those with bronchial asthma. 4. The proportion and the number of BAL neutrophils were markedly increased in patients with COB compared to those with bronchial asthma. 5. The proportion and the number of BAL eosinophils were higher in patients with bronchial asthma than in those with COB, although these defferences were not significant. The results suggest that airway inflammation in bronchial asthma is not so intensive as that in COB. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=12 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=13 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=airway inflammation (気道炎症反応) kn-keyword=airway inflammation (気道炎症反応) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=chronic obstructive bronchiolitis (慢性閉塞性細気管支炎) kn-keyword=chronic obstructive bronchiolitis (慢性閉塞性細気管支炎) en-keyword=lymphocytes (リンパ球) kn-keyword=lymphocytes (リンパ球) en-keyword=neutrophils (好中球) kn-keyword=neutrophils (好中球) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=1 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ステロイド依存性重症難治性喘息に対する温泉療法の重要性｡過去10年間の181例を対象に。 kn-title=Spa therapy is very important for the treatment of steroid-dependent intractable asthma (SDIA). Analysis of 181 patients with SDIA. en-subtitle= kn-subtitle= en-abstract=最近10年間に三朝分院へ入院し,温泉療法を受けたステロイド依存性重症難治性喘息181例を対象に,温泉療法の方法との関連のもとに,対象患者の背景について検討を加えた｡最近10年間に3種類の温泉療法が行われた｡温泉療法A(温泉プール水泳訓練)は初期(1982-1985),温泉療法B(水泳訓練+ヨードゾル吸入)は中期(1986-1989),また,温泉療法C(水泳訓練＋ヨードゾル吸入＋鉱泥湿布療法)は後期(1990-1991)に行われた｡1.当院へ入院し,温泉療法を受けたステロイド依存性重症難治性喘息(SDIA)患者の数は,1986年の2例から1991年の35例へと増加の傾向を示した｡2.SDIA患者のうち,60才以 上の症例および40才以降の発症症例の数は,1986年以降急激な増加傾向を示した｡3.鳥取県以外の他県(遠隔地)からの入院患者の頻度は,近年減少の傾向を示したが,その絶対数は増加の傾向であった｡4.血清IgE値はいずれの時期においても200IU/m?以下の症例が多い傾向が見られた｡5.臨床病型では,通常の喘息に比べIb型およびII型の頻度が高い傾向が見られた｡6.温泉療法の臨床効果は,温泉療法Aが行われた初期では70.0%,温泉療法Bの中期では74.7%,温泉療法Cの後期では89.7%であった。 kn-abstract=Characteristics of 181 patients with steroid-dependent intractable asthma (SDIA) who were admitted to our hospital and had spa therapy for last 10 years were examined in relation to the methods of spa therapy. For last 10 years, three kinds ofspa therapies were administered: spa therapy A (swimming training in a hot spring pool) in the first atage (1982-1985), spa therapy B (swimming training + inhalation of iodine salt solution) in the middle stage (1986 -1989), and spa therapy C (swimming training + inhalation of iodine salt solution + fango therapy) in the last stage (1990-1991) of this study. 1. The number of patients with SDIA who were admitted to our hospital and had spa therapy tended to increase from 2 in 1986 to 35 in 1991. 2. The number of SDIA patients over the age of 60 or over the age at onset of 40 tended to increase from the first stage to the last stage. 3. The proportion of patients from distant areas (prefectures other than Tottori) was decreasing for the last stage, although the number of these patients was increasing in recent years. 4. The proportions of patients divided by serum IgE levels and by clinical asthma types did not change for last 10 years. 5. The proportion of type Ib and type II asthma was considerably high in patients with SDIA for last 10 years. 6. Clinical effects of spa therapy were observed in 21 of the 30 (70.0%)patients with SDIA in the first stage (1982-1985) with spa therapy A, 68 of the 83 (74.7%) patients with SDIA in the middle stage (1986-1989) with spa therapy B, and 61 of the 68 (89.7%) patients with SDIA in the last stage (1990-1991) with spa therapy C. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=12 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=13 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=swimming training in a hot spring pool (温泉プール水泳訓練) kn-keyword=swimming training in a hot spring pool (温泉プール水泳訓練) en-keyword=inhalation of iodine salt solution (ヨードゾル吸入) kn-keyword=inhalation of iodine salt solution (ヨードゾル吸入) en-keyword=fango therapy (鉱泥湿布療法) kn-keyword=fango therapy (鉱泥湿布療法) en-keyword=SDIA kn-keyword=SDIA END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ステロイド依存性重症難治性喘息に対する複合温泉療法の作用機序 kn-title=Action mechanisms of complex spa therapy on steroid-dependent asthma en-subtitle= kn-subtitle= en-abstract=ステロイド依存性重症難治性喘息を対象に,温泉プール水泳訓練,ヨードゾル吸入療法.鉱泥湿布療法からなる複合温泉療法の臨床効果の解析を行った。1.複合温泉療法は,FEV(1.0%)および% PEFR値の低い症例により有効であった｡2.複合温泉療法は､細気管支領域の換気障害を示すと考えられる% V(25)値が低い症例に対して,必ずしも有効ではなかった｡3.複合温泉療法の効果は,BAL液中好中球増多(10%以上)が見られ､かつ% V(25)値が低い症例により有効であったが､同様に% V(25)値が低くても,BAL液中に好中球増多 が見られない症例に対しては,有効ではなかった｡以上の結果より,複合温泉療法はFEV(1.0%)や% PEFR値の低く,またBAL液中好中球増多が見られ,かつ% V(25)値が低いようなステロイド依存性重症難治性喘息に対して有効性が高いことが示唆された。 kn-abstract=Effects of complex spa therapy, which comprises swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy, were analyzed in patients with steroid-dependent intractable asthma (SDIA) by comparison between the subjects with and without efficacy of the therapy. 1. The complex spa therapy was effective in the patients with lower levels of FEV(1.0%) and % PEFR. 2. The complex spa therapy was not always effective in the patients with a low value of % V(25), which represents depressed airflow in the small airways. 3. The efficacy of the complex spa therapy was found in the patients showing a low value of % V(25) accompanied by BAL neutrophilia, but not found in those without increased proportion (more than 10% ) of neutrophils in BAL fluid. The results reveal that the complex spa therapy is effective in patients with SDIA showing low values of FEV(1.0%) and % PEFR, and in those with a low value of % V(25) and BAL neutrophilia. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=6 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科　 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=complex spa therapy (複合温泉療法) kn-keyword=complex spa therapy (複合温泉療法) en-keyword=ventilatory function　(換気機能) kn-keyword=ventilatory function　(換気機能) en-keyword=BAL neutrophilia　(BAL好中球増多) kn-keyword=BAL neutrophilia　(BAL好中球増多) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=107 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical opplication of a newly developed radiographic system including a fluoroscope equiped with CCD and digital image processor kn-title=新型DR装置･高精細CCDカメラ]線テレビ装置の使用経験 en-subtitle= kn-subtitle= en-abstract=We have clinically applied a newly developed radiographic system which was introduced into our institute in April 1994. This system consists of a fluoroscope, CCD (charge-coupled device) which had a million matrix, and digital image processor. This system has following advantages comparison with a conventional radiographic system ; (1) doses of x-ray exposuce during examination is less, (2) a sharp fluoroscopic image can be obtained by real-time image processing, (3) radiographic images can be kept in the recording device such as hard disc (HD) and magnetic optical disc (MOD) since this has a digital radiographic system. By connecting this system with main online system, it is expected to be able to see the various diagnostic images simulataneously as well as laboratory data at different spots of the hospital which is now available in other hospltal. kn-abstract=画像の入力部に世界初100万画素の多画素･高精細のCCD(電荷結合素子)を用いたテレビカメラを搭載したX線テレビ装置とDigital・Radiography装置を導入し,主に消化管検査を中心に多目的に任用した｡このシステムは従来のscreen/filmシステムの持つ膨大な情報量を確保しながらCCDカメラのメリットを最大限に生かしており,DRシステムの特長であるリアルタイムのCRT撮影画像表示,透視像のFREEZE確認,動態解析,画像処理等を導入することにより診断能の向上がはかれた｡更に,従来X線フィルム･撮像管に比較して被曝量の大幅な低減が期待できた｡また,デジタルであるため撮影像をHDに保管すると共にMODにも記録･再生が可能である｡今後,PACSやフイルムレス電子媒体保管への展開の可能性についても確認できた｡ en-copyright= kn-copyright= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=1 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=2 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=RiazChowdhury en-aut-sei=Riaz en-aut-mei=Chowdhury kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SatouMasataka en-aut-sei=Satou en-aut-mei=Masataka kn-aut-name=佐藤昌孝 kn-aut-sei=佐藤 kn-aut-mei=昌孝 aut-affil-num=9 ORCID= en-aut-name=UkonHiroe en-aut-sei=Ukon en-aut-mei=Hiroe kn-aut-name=右近弘栄 kn-aut-sei=右近 kn-aut-mei=弘栄 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=東芝メディカル(株) affil-num=10 en-affil= kn-affil=東芝メディカル(株) en-keyword=増感紙/フイルム (Screen/Film) kn-keyword=増感紙/フイルム (Screen/Film) en-keyword=光電子増倍管 (Image･Intensifier (l･I)) kn-keyword=光電子増倍管 (Image･Intensifier (l･I)) en-keyword=デジタル･イメージング (Digital･Imaging) kn-keyword=デジタル･イメージング (Digital･Imaging) en-keyword=電荷結合素子 (CCD) kn-keyword=電荷結合素子 (CCD) en-keyword=光磁気ディスク (MOD) kn-keyword=光磁気ディスク (MOD) en-keyword=デジタルラジオグラフィ (Digital Radiography) kn-keyword=デジタルラジオグラフィ (Digital Radiography) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=101 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on polypoid lesions of the colon. kn-title=当院における大腸ポリープの臨床的検討 en-subtitle= kn-subtitle= en-abstract=Polypoid lesions, taken by a colon fiberscope, were examined in 88 patients with polyp, who were admitted to Misasa Medical Branch, Okayama University Medical School for last 4 years. (1) Pathohistological examination of the polypoid lesions resulted in 69.2% of adenoma and 13.2% of adenocarcinoma (early cancer) ; (2) 35.5% of the polypoid lesions was detected in the sigmoid colon, 32.7% in the rectum, 16.8% in the transverse colon, 4.7% in the descending colon, 3.7% in the caecum, 1.9% in the ascending colon ; (3) The number of patients with polypoid lesion or colon cancer was increased with aging ; (4) Patients with the age under 50 years did not have polypoid lesion in the right hemicolon, while 6.5% of elder patients over age 50 has polypoid lesions in the right hemicolon ; (5) Occult blood in stool was the most popular motivation for receiving colonoscopic examinations ; (6) The second popular motivation for colonoscopy was for follow up after previous examinations. These results suggest that patients with age over 50 should be examined more carefully by total colonoscopy, and a hemoccult test in stool is an effective method for screening colonic polypoid lesions and after detection of polypoid lesions or polypectomy, reexamination by total colonoscopy is important at regular intervals. kn-abstract=1990年4月より1994年3月末までの間に岡山大学医学部附属病院三朝分院で経験した早期大腸癌を含む大腸ポリープ88例を対象に,病理組織診断,性別,年齢構成,存在部位,精査動機について検討を行い,以下の成績を得た｡(1)ポリープの69.2%は腺腫,13.2%は腺癌(早期癌)であった｡(2)男女とも加齢による大腸ポリープ及び大腸癌の頻度の増加がみられた｡(3)50歳未満の若年者では右側結腸にポリープが発見されることは稀であったが50歳以上では6.5%に認められ,高齢者における積極的なtotal colonoscopyによる観葉が重要であることが再確認された｡(4)精査動機では便潜血陽性が最多を占め,便潜血は大腸ポリープのスクリーニングにおいて有用であることが示された｡またフォローアップ目的に大腸ファイバーを施行しポリープや早期癌を発見した例も多く,フォローアップの必要性が示唆された。 en-copyright= kn-copyright= en-aut-name=TakataIchiro en-aut-sei=Takata en-aut-mei=Ichiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=MatsumuraTadashi en-aut-sei=Matsumura en-aut-mei=Tadashi kn-aut-name=松村正 kn-aut-sei=松村 kn-aut-mei=正 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=10 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=11 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学講座 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学講座 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=12 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 en-keyword=大腸ポリープ (Polyp of the colon) kn-keyword=大腸ポリープ (Polyp of the colon) en-keyword=大腸早期癌 (Early cancer of the colon) kn-keyword=大腸早期癌 (Early cancer of the colon) en-keyword=便潜血 (Occult blood in stool) kn-keyword=便潜血 (Occult blood in stool) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=55 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における血清免疫グロブリン値,末梢血リンパ球数と気管支肺胞洗浄液中の細胞成分との関連 kn-title=Serum immunoglobulin levels and peripheral lymphocyte count related to changes in cellular composition of bronchoalveolar lavage fluid in patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息26例(ステロイド依存性重症難治性喘息,SDIA 13例,非SDIA 13例)を対象に,血清免疫グロブリン,IgG,IgAおよびIgM値,および末梢血リンパ球数との関連のもとに,副腎皮質ホルモン長期投与による気道炎症細胞の出現頻度の変化について検討を加えた｡なお,年齢による影響を観察する目的で,SDIAおよび非SDIA各13例を,20-59才と60才以上の2群に分けて,それ ぞれのグループの特徴について検討した｡1.血清IgG,IgAおよびIgM値は,60才以上の症例において,いずれも非SDIA症例に比べ,SDIA症例で有意に低い値を示した｡一方,20-59才の症例群においては,IgG値のみSDIA症例で有意の低下傾向が見られた｡2.末梢血リンパ球数は,60才以上の症例では,SDIA症例で,非SDIA症例に比べ有意の低値を示したが,20-59才の症例では両群間に有意の差は見られなかった｡3.気管支肺胞洗浄(BAL)液中のリンパ球数 は,60才以上のSDIA症例で,非SDIA症例に比べ有意に少なく,また同時にこれらの症例ではBAL液中好中球が有意に多い傾向が観察された｡しかし,20-59才の症例群では,SDIAと非SDIAの間にいずれも有意の差は見られなかっ た｡これらの結果より,60才以上の症例では,20-59才の症例群に比べ,副腎皮質ホルモンの長期投与により,血清IgG,IgAおよびIgM値,末梢血リンパ球数の減少とともに,BAL液中のリンパ球減少,好中球増加をきたしやすいことが明らかにされた｡ kn-abstract=Changes in airway inflammation by glucocorticoids were examined in 26 patients with bronchial asthma, divided into two age groups ; 20-59 and 60+ years, in relation to serum immunoglobulin levels and peripheral lymphocyte count. 1. The levels of IgG, IgA and IgM were significantly lower in patients with steroid-dependent intractable asthma (SDIA) of age over 60 years than in those with non-SDIA of the same age group. In patients between the ages of 20 and 59, only serum IgG level was significantly lower in SDIA than in non-SDIA patients. 2. Peripheral lymphocyte count was significantly decreased in SDIA patients than in non-SDIA patients in age group over 60, but not in age group between 20 and 59. 3. Number of lymphocytes in bronchoalveolar lavage (BAL) fluid was significantly lower and number of BAL neutrophils was significantly higher in SDIA patients than in non-SDIA patients in age group over 60, but not in age group between 20 and 59. These results suggest that levels of IgG, IgA and IgM, and peripheral lymphocyte count were significantly suppressed in SDIA patients of age over 60, accompanied with decrease of BAL lymphocytes and increase of BAL neutrophils. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TakataIchiro en-aut-sei=Takata en-aut-mei=Ichiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=serum immunoglobulin levels (血清免疫グロブリン値) kn-keyword=serum immunoglobulin levels (血清免疫グロブリン値) en-keyword=lymphocytes (リンパ球) kn-keyword=lymphocytes (リンパ球) en-keyword=neutrophils (好中球) kn-keyword=neutrophils (好中球) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=glucocorticoids (副腎皮質ホルモン) kn-keyword=glucocorticoids (副腎皮質ホルモン) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=40 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ステロイド依存性重症難治性喘息における気道反応の特徴 kn-title=Characteristics of airway response in patients with steroid-dependent intractable asthma (SDIA) en-subtitle= kn-subtitle= en-abstract=年齢により3群(20-39才,40-59才,60才以上)に分類された気管支喘息86例(ステロイド依存性重症難治性喘息:SDIA;43例,非SDIA;43例)を対象に,気管支肺胞洗浄液(BALF)中の細胞成分および換気機能よりSDIAにおける気 道反応の特徴を検討した｡1.血清コーチゾ-ル値は,SDIA症例において, 非SDIA症例に比べいずれの年齢層においても有意の低値を示した｡2.BALF中リンパ球頻度は,40-59才および60才以上のSDIA症例において,同年齢の非SDIA症例に比べ有意の低値を示した｡一方,BALF中好中球頻度は,60才以上のSDIA症例で,同年齢層の非SDIA症例に比べ有意に高い値を示 した｡また,BALF中好酸球頻度は,いずれの年齢層においても,SDIAと非SDIA症例の間に有意の差は見られなかった｡3.換気機能では,% FVC, FEV1.0%,% MMF, % V(25)などの換気パラメーターは,60才以上の SDIA症例において,同年齢層の非SDIA症例に比べて有意の低値を示した｡ これらの結果は,40-59才あるいは60才以上のSDIA症例では,非SDIA症例に比べ,BALF中リンパ球頻度の低下,好中球頻度の増加,換気パラメーター値の低下などがより高度に見られることを示している｡ kn-abstract=Characteristics of airway response in steroid-dependent intractable asthma (SDIA) were examined in 86 asthma patients (43 with SDIA and 43 with non-SDIA) divided into three age groups: 20-39, 40-59 and 60+ years, by observing cellular composition of bronchoalveolar lavage (BAL) fluid and ventilatory function. 1. The level of serum cortisol was significantly lower in patients with SDIA than in those with non-SDIA in all age groups. 2. The proportion of lymphocytes in BAL fluid was significantly decreased in patients with SDIA compared to results in non-SDIA patients in the age between 40-59, and over 60+ years, While BAL neutrophils were significantly increased in SDIA patients compared to results in non-SDIA patients in the age group over 60 years. 3. Of ventilatory parameters, the values of % FVC, FEV(1.0%), % MMF and % V(25) were significantly lower in SDIA patients over the age of 60 compared with non-SDIA subjects of the same age group. These results show that in SDIA patients the proportion of BAL lymphocytes decreases and the proportion of BAL neutrophils increases with aging, and that ventilatory function in SDIA patients also decreases with aging compared to non-SDIA patients. en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TakataIchiro en-aut-sei=Takata en-aut-mei=Ichiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=bronchoalveolar cells (気管支肺胞洗浄液中の細胞) kn-keyword=bronchoalveolar cells (気管支肺胞洗浄液中の細胞) en-keyword=ventilatory function (換気機能) kn-keyword=ventilatory function (換気機能) en-keyword=glucocorticoids (グルココーチコイド) kn-keyword=glucocorticoids (グルココーチコイド) en-keyword=serum cortiosol levels (血清コーチゾール値) kn-keyword=serum cortiosol levels (血清コーチゾール値) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=27 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tropical calcific pancreatitis.........An overview en-subtitle= kn-subtitle= en-abstract=熱帯地方の貧困層の小児や若干成人にみられる非アルコール性の慢性膵炎で,小児期に反復する腹痛で発症し,10〜20歳で膵性糖尿病になり,20〜 30歳で死亡する類似の病像を示す症例をTropical calcific pancreatitis(熱帯性石灰化慢性膵炎)という｡高率に膵石を伴う｡成因は乳幼児期からの熱量,蛋白貰,micronutrients(亜鉛,銅,セレニウム)の摂取不足に加えて食事中シアン産生物質や環境中oxidantsなど複合因子によると推測されている｡病理像は世界各国にみられる慢性膵炎典型例に類似する｡最近は,生活環境や医療事情の改善により,全身栄養障害の減少や生存期間 の延長など病像が変貌しっつある｡糖尿病を重視する立場からはFibrocalculous pancreatic diabetesと呼ばれ,同一地域にみられるProtein-deficient pancreatic diabetesと合わせてMalnutrition-related diabetes mellitus(MRDM)と総称し,糖尿病の一亜型に分類されている。 kn-abstract=Tropical calcific pancreatitis is a nonalcoholic type of chronic pancreatitis affecting the childrens and young adults characterized clinically by recurrent abdominal pain in childhood, diabetes in adolescent and death in early childhood. Although the exact etiology is not known, malnutrition and chronic cassava toxicity either singly or in combination are presumed to be the prime factor in pancreatic injury unopposed by detoxification of free radical. Moreover micronutrients deficiency, oxidant stress and antioxidant deficiency might play substantial role. Diabetes secondary to tropical calcific pancreatitis is a distinctive and frequent problem, being named by W.H.O. study group as 'fibrocalculous pancreatic diabetes (FCPD) and classified as one of the variant of the so-called malnutrition related diabetes mellitus (MRDM). en-copyright= kn-copyright= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=3 ORCID= en-aut-name=MatsumotoShooji en-aut-sei=Matsumoto en-aut-mei=Shooji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=4 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学第2内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院 en-keyword=Tropical calcific pancreatitis (TCP) kn-keyword=Tropical calcific pancreatitis (TCP) en-keyword=malnutrition kn-keyword=malnutrition en-keyword=cassava kn-keyword=cassava en-keyword=diabetes kn-keyword=diabetes en-keyword=abdominal pain kn-keyword=abdominal pain END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=22 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study of the preparation with sodium picosulfate and PEG intestinal lavage solution for total colonoscopy. kn-title=Sodium picosulfate,PEG腸管洗浄液併用によるTotal colonoscopyの前処置法に関する検討 en-subtitle= kn-subtitle= en-abstract=The following results were obtained from a total colonoscopic study of 50 patients who received preparation with 20m? of sodium picosulfate (Laxoberon?) and PEG intestinal lavage solution (Niflec?) prior to the examination. (l) The present method in combination with a mean of 1230m? of PEG intestinal lavage solution allowed colonic cleaning for which observation was available in 48 of 50 patients. (2) With this method. no adverse reactions were observed except for mild abdominal pain, nausea, and rugitus in a few patients. (3) This method was particularly as a preparation for colonoscopic examination in elderly patients. Thus, we conclude that preparation with 20m? of sodium picosulfate and PEG intestinal lavage solution is useful for colonoscopic examination. kn-abstract=Total colonoscopyの前処置における被検者の負担軽減と良好な腸管洗浄を得る目的で,50例の大腸内視鏡検査において,前日の食事制限せず, sodium picosulfate 20m?前夜服用,検査当日PEG腸管洗浄液1?以上服用する前処置法の有用性について検討した。本前処置法によってPEG腸管洗浄液平均1230m?の服用により,50例中48例で観察可能な腸管洗浄が得られ,PEG腸管洗浄液の服用量の減量が可能であった｡腹痛,嘔気,腹鳴などの症状出現例は認めたが,重篤な副作用は認めなかった｡腸管洗浄度の点で,高齢者の大腸内視鏡検査の前処置として有用である｡以上よりSodium Picosulfate 20m?をPEG腸管洗浄液と併用することにより,優れた腸管洗浄度を得られると同時にPEG腸管洗浄液服用量の減量か可能であり,total colonoscopyの前処置として有用であることが示された。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=5 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=10 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=11 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=12 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学第2内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院 affil-num=9 en-affil= kn-affil=岡山大学三朝分院 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=勝山病院 affil-num=13 en-affil= kn-affil=八幡浜医師会立双岩病院 en-keyword=大腸内視鏡検査 (colonoscopy) kn-keyword=大腸内視鏡検査 (colonoscopy) en-keyword=前処置 (preparation) kn-keyword=前処置 (preparation) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=9 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における末梢血白血球および気管支肺胞洗浄液中の細胞からのヒスタミンおよびロイコトリエンC(4),B(4)遊離と気道過敏性 kn-title=Release of histamine and leukotrienes C(4) and B(4) from peripheral leucocytes and bronchoalveolar cells and bronchial hyperresponsiveness in patients with asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息を対象に,気管支肺胞洗浄(BAL)液中の細胞の出現頻度,末梢血白血球およびBAL細胞からのヒスタミン,ロイコトリエンC(4),B(4)遊離,気道過敏性などについて,患者年齢との関連のもとに検討を加えた｡1.BAL液中のリンパ球および好中球頻度は,60才以上の老齢症例で,20-49才の若青年症例に比べやや高い傾向が見られたが,推計学的には有意の差は見られなかった｡BAL液中の好酸球,好塩基細胞の頻度は,若青年症例で,老年症例に比べて高く,特に好塩基性細胞の頻度には両症例群間に有意の差が見られ(P<0.05)｡ 2.BAL細胞からのヒスタミン遊離は,若青年症例で,老年症例に比べ有意に多い傾向が見られた(P<0.001)｡一方,BAL細胞からのロイコトリエンC(4)遊離は,若青年症例に比べ,老年症例で多い傾向が見られたが,両症例群間に有意の差は見られなかった｡3.メサコリンに対する気道の反応性は,全般的に若青年症例で,老年症例に比べより強い傾向を示した｡そして,390μg/m?またはそれ以下の低濃度のメサコリンに反応を示す症例は,若青年症例では16例中12例(75.0%),老年症例では14例中5例(35.7%)であった｡以上の結果より,気道過敏性は,BAL細胞からの化学伝達物質遊離の変化やBAL細胞の頻度の変化とともに,加齢の影響を受けることが明らかとなった。 kn-abstract=The proportions of cells in bronchoalveolar lavage (BAL) fluid, the release of histamine, leukotrienes C(4) and B(4) from leucocytes and BAL cells, and bronchial reactivity to methacholine were examined in 40 patients with asthma in relation to patient age. 1. The proportions of lymphocytes and neutrophils in BAL fluid were higher in older patients over age 60 than in younger patients between 20 and 49. The proportions of eosinophils and basophilic cells in BAL fluid were higher in younger patients than in older patients, and the difference in the proportion of BAL basophilic cells was significant between the two groups (p<0.05). 2. The release of histamine from BAL cells was significantly higher in younger patients than in older patients (p<0.001). The release of LTC(4) from BAL cells was higher in older patients compared to younger patients. 3. Bronchial reactivity to methacholine was higher in younger patients than in older patients. The number of patients reactive to low concentration of methacholine (390μg/m? or less) was larger in younger patients (12/16 ; 75.0%) than in older patients (5/14 ; 35.7%). These results suggest that bronchial hyperresponsiveness changes with aging, accompanied by changes in the release of chemical mediators from BAL cells and in the proportion of BAL cells. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=TakataIchiro en-aut-sei=Takata en-aut-mei=Ichiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=BAL cells (BAL細胞) kn-keyword=BAL cells (BAL細胞) en-keyword=histamine (ヒスタミン) kn-keyword=histamine (ヒスタミン) en-keyword=leukotrienes (ロイコトリエン) kn-keyword=leukotrienes (ロイコトリエン) en-keyword=bronchial hyperresponsiveness (気道過敏性) kn-keyword=bronchial hyperresponsiveness (気道過敏性) en-keyword=asthma (気管支喘息） kn-keyword=asthma (気管支喘息） END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における複合温泉療法と気道炎症反応 kn-title=Complex spa therapy and airway inflammation in bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息55例を対象に,複合温泉療法(温泉プール水泳訓練+ヨードゾル吸入+鉱泥湿布療法)を試み,その臨床効果と気道炎症反応との関連について,若干の検討を加えた｡1.複合温泉療法の臨床効果では,著効15例(27.3%),有効32例(58.2%),やや有効6例,無効2例であり,明らかに有効と判断された症 例は,55例中47例(85.5%)であった｡2.複合温泉療法は,気管支肺胞洗浄液(BALF)中の細胞成分(リンパ球,好中球,好酸球など)が多い症例,すなわち気道炎症反応がより強い症例により有効であった｡このことは,複合温泉療法が,単純性の(化学伝達物質による)気管支攣縮よりも,気道炎症反応をともなった病態により強く影響を及ぼすことを示している｡3.複合温泉療法による換気機能の改善(1秒量)は,BAL液中の好中球数が少ない症例においてより高度であった｡このことは,BAL液中に高度な好中球増多が見られる症例に対しては,より長期的な複合温泉療法が必要であることを示しているものと考えられた｡ kn-abstract=Efficacy of complex spa therapy was studied in 55 patients with bronchial asthma. Complex spa therapy was effective in 47 (85.5%) of the 55 patients with bronchial asthma : marked efficacy was observed in 15 (27.3%), moderate in 32 (58.2%), slight in 6 (10.9%) and no efficacy in 2 patients (3.6%). Improvement of clinical symptoms and findings by complex spa therapy was more clearly observed in patients with an increased proportion of BAL lymphocytes, neutrophils and eosinophils. These findings suggest that complex spa therapy more affects cell infiltration in the airways than bronchoconstriction induced by chemical mediators. Improvement of ventilatory function represented by FEV1.0% value was higher in patients with a low proportion of BAL neutrophils, suggesting that patients with increased number of BAL neutrophils require longer complex spa therapy than those without BAL neutrophilia. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=TakataIchiro en-aut-sei=Takata en-aut-mei=Ichiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=complex spa therapy (複合温泉療法) kn-keyword=complex spa therapy (複合温泉療法) en-keyword=airway inflammation (気道炎症反応) kn-keyword=airway inflammation (気道炎症反応) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=85 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Experimental model of chronic pancreatitis, a review - Does it really exist? en-subtitle= kn-subtitle= en-abstract=疾患の実験モデルの作成は,その疾患の病因,病態の解明,さらに治療法の開発のために重要である｡筆者らの一人は厚生省難治性膵疾患調査研究班の班員として,慢性膵炎の病態の解明や治療法の開発に関する研究を行っており,その研究の一環として,慢性膵炎の実験モデルの作成を現在行っている｡そこで,これまで報告されている慢性膵炎の実験モデルについて概要を報告した｡種々の動物や方法でヒト慢性膵炎に病因,病態,組織像が類似するモデルの作成が試みられてきたが,そのすべてが合致するような慢性膵炎モデルは確 立されてはいない｡近年の分子生物学的研究の進歩は著しく,実験モデルへの応用が種々なされている現在,より簡便で再現性のある慢性膵炎モデルの作成が望まれるところである｡ kn-abstract=Experimental model of pancreatitis is mandatory for elucidating the pathobiology of the disease and also to see the response of a novel treatment. In addition, the need for an animal model of chronic pancreatitis is further strengthened by the relative inaccessibility and paucity of the human pancreatitis tissue. Whereas various models of acute pancreatitis and also of exocrine pancreatic tumor have been described, chronic pancr-eatitis has not been consistently reproduced in experimental animals. Many researchers attempted to establish an experimental model of chronic pancreatitis either by partially obstructing the drainage of pancreatic secretion in dogs and cats or by feeding alcohol to dogs and rats with and without temporary occlusion of the biliopancreatic duct or by surgically inducing ischaemia in the pancreas of the dogs. But, none of these models is identical with human disease. A consistently reproducible model of human chronic pancr-eatitis probably does not exist. In this expanding era of molecular biology which promises us to enhance greatly our understanding of this disease, a right experimental model of chronic pancreatitis is still in progress. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=5 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=6 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=7 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=8 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学第2内科 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=78 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Collagen degradation and in the pathogenesis of dieseases kn-title=コラーゲン分解系と疾患 en-subtitle= kn-subtitle= en-abstract=Fibrosis is the result of net accumulation of collagen in the organ. This may occur as a consequence of alterations in the synthesis of collagen, their degradation, or both. Recent investigations revealed that a decrease in collagen degradation plays a crucial role in fibrogenesis. Two pathways exist in collagen degradation : extracellular and intracellular. Each pathway has an important enzyme; that is, matrix metalloproteinases (MMP) and collagenolytic cathepsin, respectively. Collagenolytic activity is regulated at several levels. Expression of MMP and tissue inhibitors of metalloproteinase (TIMP), which act as inhibitors of MMP, is regulated independently by a number of cytokines and growth factors. MMP, which is synthesized in the cell, is secreted in a latent form. Activation of the latent MMP is controlled by TIMP and plasminogen activator inhibitor. TIMP also inhibits activated MMP which can degrade connective tissue matrices including collagens. In the condition where TIMP is predominant over MMP, activity of collagen breakdown is reduced, and consequently collagen deposition occurrs. kn-abstract=組織のコラーゲン沈着にはコラーゲン合成系と分解系の不均衡によって生ずる｡従来,主としてコラーゲン合成系が注目されていたが,最近の研究の進歩により,コラーゲン分解系が重要な役割を演ずることが明らかになってきた｡コラーゲンの分解系には細胞内と細胞外の二つの経路が存在する｡それぞれcollagenolytic cathepsinおよびmatrix metalloproteinases( MMP)がコラーゲン分解能を有する重要な酵素である｡その調節因子については細胞外の経路についての解明か進んでいる｡MMPの遺伝子の発現にはサイトカインや成長因子が関与し,IL-1やTNF-αは強力な誘導因子である｡一旦,遺伝子か発現すれば,MMPは合成され,細胞外に不活性型(latent form)で分泌される｡不活性型のMMPが活性化する過程にはplasminogen activator inhibitorやtissue inhibitors of metalloproteinases(TIMP)などの阻害因子が存在し,MMP活性を調節する｡TIMPの遺伝子の発現にもサイトカインや成長因子が関与する｡MMPがTIMPを上回るような病態では組織破壊が,逆にTIMPがMMPを上回るような病態では綿維化が生ずる｡コラーゲン分解能の障害が線維化の維持や不可逆性に関与することが推察される。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=3 ORCID= en-aut-name=YamashitaHaruhiro en-aut-sei=Yamashita en-aut-mei=Haruhiro kn-aut-name=山下晴弘 kn-aut-sei=山下 kn-aut-mei=晴弘 aut-affil-num=4 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=5 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=6 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=7 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=8 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学第2内科 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=岡山大学三朝分院 en-keyword=線維化 (Fibrosis) kn-keyword=線維化 (Fibrosis) en-keyword=コラーゲン (Collagen) kn-keyword=コラーゲン (Collagen) en-keyword=TIMP (tissue inhibitor of metalloproteinase) kn-keyword=TIMP (tissue inhibitor of metalloproteinase) en-keyword=MMP (matrix metalloproteinase) kn-keyword=MMP (matrix metalloproteinase) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=72 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy and quality of life in patients with bronchial asthma kn-title=温泉療法と気管支喘息患者のQOL en-subtitle= kn-subtitle= en-abstract=Bronchial asthma is in qeneral a disease with good prognosis and can be controlled with usual antiasthmatic drugs. However, there are some patients whose asthma attacks can be controlled only with use of qlucocorticoids. In these patients, adverse side effects of many kinds of drugs containing bronchodilators and qlucocorticoids, and exercise-induced asthma attacks are often observed. Thus, the patients have to keep limitation of exercise during treatment of their asthma attacks, leading to decrease psychical activity. Complex spa therapy for bronchial asthma consists of swimming training in a hot spring pool (exercise), inhalation of iodine salt solution and fango therapy. Spa therapy has two kinds of actions : direct action to airways and indirect action to other organs except airways. The direct action of spa therapy improves subjective and objective symptoms, and ventilatory function, and suppress bronchial hyperresponsiveness. In contrast, improvemment of suppressed function of adrenocortical glands, of mental activity, and of autonomic nerve system is observed as indirect action of spa therapy. These actions play an important role for improvement of QOL of patients with bronchial asthma. kn-abstract=気管支喘息のなかでも,ステロイド依存性重症難治性喘息では,気管支拡張薬その他の抗喘息薬のみでは発作のコントロ-ルが極めて困難であり,したがって副腎皮質ホルモンの長期投与を余儀なくされる｡そして,投与薬剤,特に気管支拡張薬の心臓刺激作用や副腎皮質ホルモンの副作用,さらには運動誘発喘息がひき起こされやすいなどの理由により,体動制限が加えられることが多い｡このことが,また精神活動の低下へとつながる｡したがって,重症難治性喘息患者のQuality of life (QOL)を高めるためには,薬剤の副作用をできるだけ低くするための投与薬剤の減量をはかるとともに,十分な運動のもとに治療を行い全身状態の改善,それにともなう精神活動の活性化をはかる必要がある｡かかる観点からすれば,温泉療法は最も理想的な治療法であり,その直接作用(気道への作用:気道浄化作用,気道粘膜正常化作用)により,白,他覚症状の改善,換気機能の改善,気道過敏性の低下などが観察される｡また,間接作用(気道以外への作用)により,全身状態の改善,自律神経系の安定化作用,副腎皮質機能の改善作用などが見られる｡すなわち,重症難治性喘息に対する温泉療法では,十分な運動のもとに,精神活動の活性化をともなった喘息症状の改善がはかられるため,患者のQOLをより一層高めることができると判断される｡ en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=重症難治性喘息 (lntractable asthma) kn-keyword=重症難治性喘息 (lntractable asthma) en-keyword=運動 (exercise) kn-keyword=運動 (exercise) en-keyword=精神活動 (phychical activity) kn-keyword=精神活動 (phychical activity) en-keyword=QOL kn-keyword=QOL END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=30 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者の血清コーチゾール値について. 副腎皮質ホルモン投与および年齢との関連 kn-title=Serum cortisol levels in patients with bronchial asthma. Relationship to glucocorticoid therapy and patient age. en-subtitle= kn-subtitle= en-abstract=気管支喘息94例を対象に,副腎皮質ホルモン投与および年齢との関連のもとに,血清コーチゾール値の変動を観察した｡まず副腎皮質ホルモンの投与量および投与期間により以下の3群に分けて検討した｡グループA :副腎皮質ホルモン,プレドニソロンに換算して1日5mg以上を2年間以上にわたり使用している症例,グループB:プレドニソロン1日5mg以下で2年間以内の使用症例, グループC:副腎皮質ホルモンを全く使用していない症例｡その結果,グループAの血清コーチゾ-ル値(2.4±1.2mcg/?)は,グループB (6.8±3.7mcg/?)(p 0.01)やC(12.6±3.9mcg/?)(p 0.001)に比べ有意に低い値であった｡2､グループCでは,70才以上の症例の血清コーチゾ-ル値は,0-39才の症例(p 0.0l),40-49才の症例(p 0.05),そして,50-59才の症例(p 0.02)に比べ有意に低い値であった｡これらの結果は,血清コーチゾール値は,副腎 皮質ホルモンの投与量や投与期間以外にも､加齢による影響を受ける可能性を示唆している｡ kn-abstract=Serum cortisol levels were examined in 94 patients with bronchial asthma in relation to dose of glucocorticoids and age. 1. The level of serum cortisol was significantly lower in group A patients, treated with glucocorticoids (prednisolone of 5mg/day or more) for more than 2 years, (2.4±1.2mcg/?) than in group B, treated with glucocorticoids (prednisolone of 5mg or less) for less than 2 years, (6.8±3.7mcg/?) (p<0.001) and in group C, treated without glucocorticoids, (12.6±3.9mcg/?) (p<0.001). The serum cortisol level was also significantly lower in group B than in group C (p<0.001). 2. The level of serum cortisol was significantly lower in patients over the age of 70 compared to that in those aged between 0 and 39 years (p<0.01) and those between 40 and 49 (p<0.05), and those between 50 and 59 (p<0.02). The level was also lower in patients between 60 and 69 compared to that in those between 0 and 39, however, this was not significant. These results demonstrate that the level of serum cortisol decreases by long-term glucocorticoid regimen and with aging. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=serum cortisol level (血清コーチゾール) kn-keyword=serum cortisol level (血清コーチゾール) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=clinical asthma type (臨床病型) kn-keyword=clinical asthma type (臨床病型) en-keyword=glucocorticoids (副腎皮質ホルモン) kn-keyword=glucocorticoids (副腎皮質ホルモン) en-keyword=aging (加齢) kn-keyword=aging (加齢) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=21 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=老年者気管支喘息の各臨床病型における換気機能の特徴 kn-title=Characteristics of ventilatory function in clinical types of bronchial asthma in the elderly en-subtitle= kn-subtitle= en-abstract=気管支喘息55例(老年症例-65才以上-25例,若年症例-59才以下-30例)における換気機能の特徴について,各臨床病型別に検討を加えた｡1.まず対象症例の臨床病型の病態的特徴を,気管支肺胞洗浄(BAL)液中の細胞成分で検討 すると,Uの細気管支閉塞型の症例では,好中球の増加が,またIa-2やIbの過分泌型の症例では好酸球の増加が特徴的であった｡2.% FVC,FEVL(1.0%),% PEFRなどの換気パラメーターは,U型において他の病型に比べ低値を示す傾向は見られたが,各病型間に有意差は見られなかった｡3.% MMF,% V(50),% V(25)などのどちらかと言えば小ないし細気管支領域の換気障害を示す換気パラメーターの値は,老年および若年症例ともU型(細気管支閉塞型)において最も低い値が示された｡そして,若年症例では,U型の症例においてこれからの換気パラメーターの値は,Ia-1型(単純性気管支攣縮型)に比べ有意に低い値を示した｡しかし,老年症例ではU型におけるこれらの換気パラメータ-の値は,他の臨床病型との問に有意の差は見られなかった｡ kn-abstract=Ventilatory function was examined in 55 patients with asthma (25 older patients over the age of 60 and 30 younger patients under the age of 59) in relation to four clinical types classified by clinical symptoms and signs. 1. Regarding cellular composition of bronchoalveolar lavage (BAL) fluid, number of BAL neutrophils was significantly increased in type II, bronchiolar obstruction type, of older and younger patients compared to that in type la-1 and type la-2 of same patients. In contrast, BAL eosinophilia was observed in type la-2 of both older and younger patients and in type Ib of younger patients. 2. The values of % FVC, FEV(1.0%) and % PEFR were not significantly different among four clinical types of asthma and between older and younger patients, although the values of these ventilatory parameters in type II asthma showed a tendency to be lower compared to other clinical types. 3. The values of % MMF, % V(50), and % V(25), showing ventilatory dysfunction of small airways, were lowest in type II asthma of both older and younger patients among four clinical types. A significant difference in these ventilatory parameters of type II asthma compared to type la-1 asthma was observed in younger patients, but not in older patients. These results show that ventilatory dysfunction of small airways is related to clinical asthma types in younger patients, and to aging rather than asthma types in older patients. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=Ventilatory function (換気機能) kn-keyword=Ventilatory function (換気機能) en-keyword=Clinical asthma type (臨床病型) kn-keyword=Clinical asthma type (臨床病型) en-keyword=BAL cells (BAL細胞) kn-keyword=BAL cells (BAL細胞) en-keyword=aging (加齢) kn-keyword=aging (加齢) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=14 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者の気管支肺胞細胞からのヒスタミンとロイコトリエンC4遊離 ―アトピー性喘息におけるヒスタミンの役割について― kn-title=Release of histamine and leukotriene C4 from bronchoalveolar cells in patients with bronchial asthma. A role of histamine in atopic asthma. en-subtitle= kn-subtitle= en-abstract=気管支喘息発作初期に関与する液性因子(ヒスタミン,ロイコトリエン)の役割を明らかにするために,気管支肺胞洗浄(BAL)細胞からのカルシウムイオノフォアA23187によるヒスタミンとロイコトリエンC4 (LTC4)遊離の検討を行った｡対象はアトピー性喘息患者7名,非アトピー性喘息患者7名とした｡1.BAL液中の好塩基性細胞の比率は,アトピー性喘息患者において有意に高値を示した｡2.BAL液中ヒスタミン濃度は非アトピー性喘息患者(0mcg/m?)に比して,アトピー性喘息患者(2.3mcg/m?)において有意に高値を示した｡一方,BAL液中LTC4濃度は,アトピー性喘息患者(0.5ng/m?)に比し て非アトピー性喘息患者(2.4ng/m?)において,高値を示したが,有意差は見られなかった｡3.BAL細胞からのヒスタミン遊離は非アトピー性喘息患者(0%)に比して,アトピー性喘息患者(32.6%)において有意に高値を示した｡LTC4遊離はアトピー性瑞息患者(3.5ng/10(6)胞)に比して,非アトピー性喘息患者(ll.3ng/10(6)細胞)において有意に高値を示した｡以上より,喘息発作初期に関与する液性因子としては,アトピー性喘息患者においてはヒスタミンが重要であり,非アトピー性喘息患者においてはLTC4が,重要であることが,明らかになった。 kn-abstract=To clarify the main humoral triggering factor (histamine and/or leukotriene) of the early stage of asthma attacks, the release of histamine and leukotriene C4 (LTC4) from bronchoalveolar lavage (BAL) cells stimulated with Ca ionophore A23187 was examined in 7 patients with atopic asthma, and the results were compared to those in 7 nonatopic asthma patients. 1. The proportion of BAL basophilic cells was significantly higher in atopic patients than in nonatopic patients (p<0.05). 2. The content of histamine in BAL fluid was significantly higher in atopic (2.3mcg/m?) comparted to that in nonatopic patients (0mcg/m?)(p<0.001). The content of LTC4 was high in nonatopic (2.4ng/m?) than in atopic patients (0.5ng/ m?), however, this was not significant. 3. The release of histamine from BAL cells was 32.6% in atopic and 0% in nonatopic patients, and this was significant (p<0.001). The release of LTC4 from BAL cells was significantly higher in nonatopic (11.3ng/10(6)cell) than in atopic (3.5ng/10(6)cell)(p<0.02). The results demonstrate that histamine play more important role in atopic patients as a main triggering factor of attacks than LTC4. In contrast, in nonatopic patients, LTC4 is more predominant than histamine during early stage of asthma attacks. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院臨床検査医学 en-keyword=Histamine kn-keyword=Histamine en-keyword=LTC4 kn-keyword=LTC4 en-keyword=BAL cells kn-keyword=BAL cells en-keyword=atopic asthma kn-keyword=atopic asthma END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ダニ喘息における気道遊走細胞からのヒスタミン遊離の加齢による減少 kn-title=Decrease in histamine release from bronchoalveolarcells with aging in patients with atopic asthma sensitive to house dust mite en-subtitle= kn-subtitle= en-abstract=ダニ喘息14例を対象に,ハウスダストエキスによる気道遊走細胞からのヒスタミン遊離と加齢との関連について検討を加えた｡1.気管支肺胞洗浄液(BALF)中の総細胞数は,20-39才の症例群(6.25×10(6)) に比べ,40才以 上の症例群(9.1×10(6)) でやや多い傾向が見られたが,推計学的には有意差は見られなかった｡2.BALF中好酸球数は,20-39才と40才以上の症例群間に差は見られなかった｡3.BALF中好塩基性細胞数は,40才以上の症例群(0.39±0.24×10(2)/m?)に比べ,20-39才の症例群(1.85±1.03×10(2)/m?)において有意に多い傾向が見られた(P<0.001)｡4.ハウスダストエキスによるBALF中細胞からのヒスタミン遊離は,40才以上の症例群(0%) に比べ20-39才の症例群(38.1±24.8%)において有意に高い結果が得られた(P<0.001)。これらの結果より,ダニ喘息(アトピー型喘息)における気道遊走細胞からのヒスタミン遊離は,加齢とともに減少することが示唆された｡ kn-abstract=Histamine release from bronchoalveolar cells induced by house dust mite (HDm) was compared in patients with atopic asthma sensitive to HDm in relation to age. 1. Total cell number in bronchoalveolar lavage (BAL) fluid was larger in patients over the age of 40 years (9.10×10(6)) than in those aged between 20 and 39 years (6.25×10(6)), however, this was not significant. 2. Number of BAL eosinophils was not significantly different between the two age groups. 3. Number of BAL basophilic cells was significantly higher in younger patients (20-39 years) (1.85±1.03×10(2)/m?) than in older patients (40+ years) (0.39±0.24×10(2)/m?) (p<0.001). 4. Histamine release from BAL cells induced by HDm was significantly higher in younger patients (38.1±24.8%) than in older patients (0%) (p<0.001). These results suggest that histamine release from BAL cells in patients with HDm allergy decreases with aging. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保ｱ泰弘 kn-aut-sei=保ｱ kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=9 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=House dust allergy kn-keyword=House dust allergy en-keyword=Histamine release kn-keyword=Histamine release en-keyword=Bronchoalveolar cells kn-keyword=Bronchoalveolar cells END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=121 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of multiple pancreatic cysts with K-ras point mutation in pure pancreatic juice kn-title=膵液のK-ras遺伝子の突然変異を認めた多発性膵嚢胞の1例 en-subtitle= kn-subtitle= en-abstract=Pancreatic cancer is the one of the leading causes of death among cancer deaths and the early diagnosis is one of the main topics of pancreatic research. Mutation of K-ras oncogene at codon 12 has been reported in pancreatic adenoma, hyperplasia of the pancreatic duct, and also in pancreatic cancer, Recently, detection of K-ras point mutation in pure pancreatic juice is underinvestigation as a potential tool of early diagnosis of pancreatic cancer by setting a certain cut-off value. We recently experienced a case of multiple pancreatic cysts without any malignant cells in pancreatic juice, but with a positve point mutation of K-ras oncogene. Operation was deferred after obtaining informed consent from the family, because the lesions were so multiple and extensive as to require total pancreatectomy. Eighteen months follow-up studies did not reveal any deterioration in imaging tests as well as clinical picture. kn-abstract=膵癌の早期診断を行うために,最近の進歩の著しい遺伝子診断を用いて,膵液中のK-ras遺伝子の点突然変異の検討がなされている｡われわれは膵液の細胞診は陰性であるが,K-ras遺伝子の点突然変異を認め,膵全体に多発する膵嚢胞の1例を経験した｡本例は悪性であるとの確診が得られないことや切除するとなれば膵全摘となることなどのために,経過観察を行っているが,18カ月後の現在,嚢胞の増大など認めていない｡膵癌の遺伝子診断の文献的考察を含め,報告する｡ en-copyright= kn-copyright= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=5 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学第2内科 affil-num=2 en-affil= kn-affil=岡山大学中央検査部 affil-num=3 en-affil= kn-affil=岡山大学中央検査部 affil-num=4 en-affil= kn-affil=岡山大学中央検査部 affil-num=5 en-affil= kn-affil=岡山大学中央検査部 affil-num=6 en-affil= kn-affil=岡山大学第2内科 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=勝山病院 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 en-keyword=膵嚢胞 (pancreatic cyst) kn-keyword=膵嚢胞 (pancreatic cyst) en-keyword=膵液 (pancreatic juice) kn-keyword=膵液 (pancreatic juice) en-keyword=K-ras遺伝子 (K-ras oncogene) kn-keyword=K-ras遺伝子 (K-ras oncogene) en-keyword=点突然変異 (point mutation) kn-keyword=点突然変異 (point mutation) en-keyword=細胞診 (cytology) kn-keyword=細胞診 (cytology) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=99 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息に対する複合温泉療法の作用機序 3.気道炎症反応との関連 kn-title=Action mechanisms of complex spa therapy on bronchial asthma. 3. Relationship to airway inflammation en-subtitle= kn-subtitle= en-abstract=気道炎症反応の程度や特徴が,気管支肺胞洗浄液(BAL)中の細胞成分によって評価された｡Ia.単純性気管支攣縮型,Ib.気管支攣縮+過分泌型,U.細気管支閉塞型などの各臨床病型は気道炎症反応と関連している｡BAL液中好中球増多は,U型喘息の特徴的所見であり,また好酸球増多はIb型喘息でしばしば観察される｡気道過敏性もまた気道炎症反応と関連している｡温泉療法の作用機序としては,温泉療法にIgEにmediateされるアレルギー反応(液性因子相)を抑制する作用がないことから,気道炎症反応(細胞性因子相)の抑制が推測されている｡実際,温泉療法は,気道炎症反応が軽度なIa型喘息に比べ,Ib型やU型などの明らかに気道炎症反応をともなう病型に対してより有効である｡気道過敏性もまた温泉療法により改善される｡これらの 結果から,温泉療法は,気道を清浄化し,気道粘膜を正常化することによって,気道炎症反応を抑制していくものと考えられる｡ kn-abstract=The degree and characteristic of airway inflammation were evaluated by the proportions of bronchoalveolar lavage (BAL) cells. Clinical asthma types such as Ia. simple bronchoconstriction, Ib. bronchoconstriction + hypersecretion, and U. bronchiolar obstruction correlate with airway inflammation. The increased proportion BAL　neutrophils is characteristic of type U asthma, and increase in BAL eosinophil count is often observed in type Ib asthma. Bronchial hyperresponsiveness also correlates with airway inflammation. Action of spa therapy has been speculated to be related to airway inflammation, since the therapy has no action inhibiting IgE-mediated allergic reaction. In fact, spa therapy is more effective in patients with type Ib and type U than in those with type Ia showing slight degree of airway inflammation. Bronchial hyperresponsiveness is also improved by spa therapy. From a point of view, the direct action of spa therapy may be to clean airways and improve damaged mucous membrane of the airways, leading to suppression of airway inflammation. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=7 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=Spa therapy (温泉療法) kn-keyword=Spa therapy (温泉療法) en-keyword=Airway inflammation (気道炎症反応) kn-keyword=Airway inflammation (気道炎症反応) en-keyword=BAL eosinophilia (BAL好酸球増多) kn-keyword=BAL eosinophilia (BAL好酸球増多) en-keyword=BAL neutrophilia (BAL好中球増多) kn-keyword=BAL neutrophilia (BAL好中球増多) en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=115 end-page=120 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mechanisms of pancreatic fibrosis kn-title=膵線維化のメカニズム en-subtitle= kn-subtitle= en-abstract=Pancreatic fibrosis is an outstanding morphological feature in chronic pancreatis although it is seen in pancreatic cancer and convalescent stage of acute pancreatitis. Progressive fibrosis in chronic pancreatitis leads to the destruction and contributes to irreversiblity of chronic pancreatitis. Exact mechanisms of pancreatic fibrosis is not yet unclear, although advances in molecular biology have revealed possible roles of cytokines and growth factors in it. We summarized our understanding of pancreatic fibrosis in the revIew. kn-abstract=膵の線維化は慢性膵炎に特徴的な病理組織所見の一つであるが,その発生機序については不明な点か多い｡慢性膵炎はいったん発症すれば,進行性かつ非可逆性であるとされるが,その非可逆性に膵の線維化が関与するとされる｡膵の線維化の発生機序を明らかにし,線維化に対する根本的な治療法の確立が望まれるところである｡そこで,本稿では今後の膵の線維化の研究課題を明らかにする目的で,現在までの膵臓線維化の発生機序に関する知見を整理した｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=6 ORCID= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=9 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=10 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学中央検査部 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学中央検査部 affil-num=5 en-affil= kn-affil=岡山大学中央検査部 affil-num=6 en-affil= kn-affil=岡山大学第2外科 affil-num=7 en-affil= kn-affil=岡山大学第2外科 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=11 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=12 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=膵臓 (pancreas) kn-keyword=膵臓 (pancreas) en-keyword=線維化 (fibrosis) kn-keyword=線維化 (fibrosis) en-keyword=サイトカイン (cytokine) kn-keyword=サイトカイン (cytokine) en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=85 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息に対する複合温泉療法の作用機序 1.温泉療法の評価方法との関連 kn-title=Action mechanisms of complex spa therapy on bronchial asthma. 1. Relationship to evaluation of spa therapy en-subtitle= kn-subtitle= en-abstract=複合温泉療法(温泉プール水泳訓練,ヨードゾル吸入,鉱泥湿布療法)の作用機序が,年齢,臨床病型,気道炎症反応との関連のもとに検討された｡温泉療法の作用機序は,2種類の臨床効果,すなわち,直接効果と間接効果により観察された｡自,他覚症状の改善,換気機能の改善,そして,気道過敏性の改善などが,温泉療法の直接効果として,また,副腎皮質機能の改善が間接効果とし て観察された｡温泉療法の臨床効果は,40才以上の症例においてより有効であり,また,臨床病型別では､Ia型に比べ,Ib型およびU型においてより有効であった｡Ib型やU型の気管支喘息では,温泉療法の作用機序と気道炎症反応との間に密接な関連が認められた｡ kn-abstract=Action mechanisms of complex spa therapy (swimming training in a hot spring pool, inhalation with iodine salt solution, and fango therapy) were studied in relation to patient age, clinical asthma type, and airway inflammation. Actions of spa therapy were observed by two clinical effects : direct and indirect effects. Improvement of subjective symptoms, ventilatory function, and bronchial hyperresponsiveness was observed as direct effects of spa therapy, and improvement of suppressed function of adrenocortical glands as indirect effects of the therapy. The clinical effects of spa therapy were higher in patients over the age of 40. Regarding clinical asthma type, the effects were larger in patients with type Ib and type II asthma than in those with type Ia. The efficacy of spa therapy was closely related with airway inflammation in patients with type Ib and type II asthma. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=7 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=complex spa therapy (複合温泉療法) kn-keyword=complex spa therapy (複合温泉療法) en-keyword=clinical asthma type (臨床病型) kn-keyword=clinical asthma type (臨床病型) en-keyword=ventilatory function (換気機能) kn-keyword=ventilatory function (換気機能) en-keyword=bronchial hyperresponsiveness (気道過敏性) kn-keyword=bronchial hyperresponsiveness (気道過敏性) en-keyword=adrenocortical glands (副腎皮質) kn-keyword=adrenocortical glands (副腎皮質) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=79 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=U型喘息(細気管支閉塞型)と気管支肺胞洗浄液の好中球数 kn-title=Type U (bronchiolar obstruction) asthma and number of neutrophils in bronchoalveolar lavage (BAL) fluid en-subtitle= kn-subtitle= en-abstract=気管支喘息は,その臨床症状より,Ia型(Ia-1およびIa-2),Ib型およびU型の3つの病型に分けることができる(臨床分類)｡また,同時に臨床所見および検査により分類することができる(スコアー分類)｡いずれの分類においても,BAL液中の好中球の著増および高度な% V25値の低下がU細気管支閉塞型の特徴的所見である｡しかしながら,BAL液中の好中球の増加をともなわないU型喘息が存在することが明らかにされている｡これらの症例では,BAL液 中好中球増加をともなう症例に比べ平均年齢が高い｡しかし,FEVl.0% 値､BAL液中リンパ球頻度や血清IgG値などは､好中球増加をともなう症例ほどの低下傾向は見られない｡これらの結果はBAL液中好中球増加をともなうU型z喘息の発症機序には､液性および細胞性免疫能の低下が､また､BAL液中好中球増加をともなわないU型喘息では､加齢がある程度関連していることを示 している。 kn-abstract=Bronchial asthma is classified into three types ; type Ia (Ia-1 and Ia-2), type Ib, and type U, by clinical symptoms (clinical diagnosis). Asthma is also classified by clinical findings and examinations (score diagnosis). Both classification systems show that markedly increased proportion of BAL neutrophils and marked decrease in % V25 value are characteristic of type U, bronchiolar　obstruction, asthma. However, there are some type U asthma patients without BAL neutrophilia. In these patients, age is higher compared to those with BAL enutrophlia. Decrease in FEV1.0% value and decrease in the proportion of BAL lympocytes and serum IgG level, are not so remarkable as decrease in those with BAL neutrophilia. It has been suggested that type U asthma with BAL neutrophilia correlates with suppression of humoral and cellular immunity, and same type of astma without BAL neutrophilia is in part caused by aging. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=7 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=8 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=12 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=13 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=Asthma classification (喘息分類) kn-keyword=Asthma classification (喘息分類) en-keyword=BAL lymphocytes (BALリンパ球) kn-keyword=BAL lymphocytes (BALリンパ球) en-keyword=BAL neutrophils (BAL好中球) kn-keyword=BAL neutrophils (BAL好中球) en-keyword=% V25 value kn-keyword=% V25 value en-keyword=U型喘息 kn-keyword=U型喘息 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=75 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Gastro-biliary motility in patients with non-ulcer dyspepsia kn-title=上腹部不定愁訴患者の胃･胆嚢運動に関する研究 en-subtitle= kn-subtitle= en-abstract=Subjective symptoms are quite similar between cystic duct syndrome (CDS) and non-ulcer dyspepsia (NUD) : epigastralgia, hypochondralgia and vague complaints in the upper part of the abdomen. Recently, there has been several reports suggesting that the cause of these disorders is postprandial dysmotility in the gallbladder and stomach. However, there has been no report suggesting incoordination of postprandial gastrobilialy motility as the cause of tha above mentioned complaints in these disorders. The aim of this study was to define the difference of postprandial gastrobiliary motility between patients with NUD and controls. Eight patients with NUD and 10 controls were studied. Gastric emptying time of liquid meal and gallbladder contraction were measured, simultaneously. There was no significant difference between study patients and controls when gastric emptying time and gallbladder contraction rate were compared in isolation. However, when these two parameters were assessed in combination, gastric emptying time was linearly correlated with minimum ballbladder contraction time in controls but not in patients. We conclude that the incoordination between gastric emptying and minimal gallbladder contraction may be one of the major causes of the symptoms in NUD. kn-abstract=現在,上腹部不定愁訴の原因は特定されていない｡その原因を解明するため,上腹部不定愁訴患者8人と健常対照者10人に対して液体食の胃排出能と,食事負荷による胆嚢収縮能を測定した｡胃排出時間,胆嚢収縮能はいずれも両者に有意な差は認められなかった｡健常対照者では胃排出時間と胆嚢収縮時間に有意な相関関係が認められたが,上腹部不定愁訴群では相関関係は認められなかった｡上腹部不定愁訴の原因として胃･胆嚢協調運動障害の存在が示唆 された。 en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=5 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=6 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=9 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=10 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=12 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=胃運動 (Gastric motility) kn-keyword=胃運動 (Gastric motility) en-keyword=胆嚢運動 (Biliary motility) kn-keyword=胆嚢運動 (Biliary motility) en-keyword=不定愁訴 (indefinite complaint) kn-keyword=不定愁訴 (indefinite complaint) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=71 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Usefulness of retinol binding protein as a marker for the assessment of nutritional uptake for the preparation of colonosocpy kn-title=大腸前処置法の栄養評価としてのレチノール結合蛋白の有用性の検討 en-subtitle= kn-subtitle= en-abstract=The objective of this study was to evaluate the usefulness of retinol binding protein (RBP), one of rapid turnover proteins, for the assessment of nutritional aspect of the preparation for colonoscopy. Blood samples were drawed before the preparation and after the colonoscopic examination and serum RBP was determined by laser nephrometory. Group A consisted of 10 patients who were administered intestinal lavage solution (Niflec) without no low residual diet. Group B consisted of 27 patients who were adminstered low residual diet for 1 day. Group C consisted of 27 patients who were administered low residual diet for the two consecutive days before colonosocopic examination with intestinal lavage solution and magnesium citrate because sufficient cleanup of intestine were not expected by using the ordinary preparations. The values of serum RBP significantly decreased in group C after the preparation although no significant changes were observed in group A and Group B. We emphasized in estimating the preparation for the colonoscopy assessment of nutrition using serum RBP was needed as well as colonic cleaning. kn-abstract=大腸内視鏡検査の前処置を栄養面から評価する目的で前処置前後にrapid turnover proteinである血中レチノール結合蛋白の変動を検討した｡前日に普通食を用い,当日ニフレックを使用した10例,検査1日前に低残渣食を用いた27例,通常の前処置では良好な腸管洗浄が得られないために検査前2日間低残渣食を用いた27例の3群について,前処置開始前と検査終了後に血中レチノール結合蛋白の変動をみたところ,検査前2日間低残渣食服用群で有意の低下を認めた｡前日普通食群では検査前後で変化を認めず,1日低残渣食服用群では低下傾向を認めたが,有意差は認めなかった｡これまで前処置の成否は腸管洗浄度の面で評価されてきたが,血中レチノール結合蛋白を目標として用いることにより栄養面から評価することができることが考えられた。 en-copyright= kn-copyright= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=1 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=5 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=6 ORCID= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=7 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=10 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=11 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=12 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=2 en-affil= kn-affil=勝山病院外科 affil-num=3 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=4 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=7 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=12 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=13 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=レチノール結合蛋白 (retinol binding protein) kn-keyword=レチノール結合蛋白 (retinol binding protein) en-keyword=大腸内視鏡 (colonoscopy) kn-keyword=大腸内視鏡 (colonoscopy) en-keyword=前処置 (preparation) kn-keyword=前処置 (preparation) en-keyword=栄養評価 (nutritional assessment) kn-keyword=栄養評価 (nutritional assessment) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=63 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=サーモグラフィーによる体表面温度の測定 kn-title=Evaluation of Body Surface Temperature by Thermography en-subtitle= kn-subtitle= en-abstract=健常人並びに糖尿病患者を対象にして下肢の体表面温度を測定した｡測定にはサーモグラフィーを用い,得られた画像の数値化にはコンピュータを用いた画像処理システムを利用した｡健常人を用いた実験では,20℃の水を用いた冷水負荷を5分間行うことにより,冷水負荷後,下肢の体表面温度は時間とともに上昇して30分後に良好な回復を得ることができた｡画像処理により28℃以上の体表面温度を呈した下肢の面積を負荷前と比較したところ,回復率は,2名の健常人についてみるとそれぞれ83%,88%であった｡27℃で画像処理を行った場合には回復率は93%となり過大評価される可能性があった｡また,29℃で画像処理を行ったところに,逆に,64%となり過少評価される可能性があり,28℃が最も良い条件であった｡この様な条件下で,糖尿病患者7名について同様に測定を行ったところ,1名は健常人と同じく99%の良好な回復率を呈した｡しかし,他の1名は56%であり,残りの,5名は6%以下であった｡この様に,糖尿病患者では,下肢の体表面温度の冷水負荷後の回復率に顕著な差を認めた｡この差は,糖尿病患者における,末梢循環障害の程度を反映しているものと考えられた｡この様にコンピュータを用いた画像処理システムの応用によりサーモグラフィーの画像は数値化することが出来,測定結果はより客観的に据えることが可能となった｡画像処理されたサーモグラフィーは下肢の循環障害を持つ患者の末梢血流量の評価に有用な測定方法であると考えられた。 kn-abstract=Body Surface Temperature was observed by thermography. The surface temperature of a healthy person's lower limbs, after being cooled in a water bath, increased in parallel with time. Patients with Diabetes Mellitus had different patterns in the rate of increase of the surface temperature. After cold loading, one patient had a 99% recovery ratio of surface temperature, the same level as healthy volunteers (83%, and 88%), as calculated by a picture processing program with the computerized thermotracer. However, the recovery ratio of other patients was poorer, ranging from 56% to under 6% recovery. This measurement of elevation of body temperature is useful for the estimation of peripheral blood flow in patients with lower limbcirculation failure. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=2 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=3 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=IkedaSatoru en-aut-sei=Ikeda en-aut-mei=Satoru kn-aut-name=池田敏 kn-aut-sei=池田 kn-aut-mei=敏 aut-affil-num=12 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部公衆衛生学 affil-num=13 en-affil= kn-affil=岡山大学医学部公衆衛生学 en-keyword=Thermography (サーモグラフィー) kn-keyword=Thermography (サーモグラフィー) en-keyword=Diabetes Mellitus (糖尿病) kn-keyword=Diabetes Mellitus (糖尿病) en-keyword=Peripheral Circulation (末梢循環) kn-keyword=Peripheral Circulation (末梢循環) en-keyword=Cold Loading (冷水負荷) kn-keyword=Cold Loading (冷水負荷) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=57 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息症例に対する鼻腔内ステロイド療法 kn-title=Intranasal glucocorticoid therapy in asthmatic patients with mucosal abnormalities of sinonasal cavity en-subtitle= kn-subtitle= en-abstract=気管支喘息症例には,アレルギー性鼻炎や慢性副鼻腔炎の合併が認められる｡鼻腔内への吸入ステロイド投与が喘息症状を改善したという報告も存在し,鼻腔病変が下気道の反応に何らかの影響を及ぼしている可能性が考えられる｡今回,気管支喘息にて入院した72才の女性の症例を呈示する｡労作性呼吸困難と多量の喀痰排出が認められ,入院後の投薬や温泉療法にて呼吸困難は改善したが,喀痰排出は減少せず,ピークフロー値も上昇が認められなかった｡明らかな後鼻漏が認められ,CTにて両側鼻腔粘膜の著明な肥厚の所見が見られたため,鼻腔内吸入ステロイド投与を開始した｡開始後,喀痰排出量,ピークフロー値は著明な改善を示した｡この症例のように,鼻腔あるいは副 鼻腔に対する治療が喘息症状を改善する症例が存在する可能性が考えられた｡ kn-abstract=Bronchial asthma is often accompanied with allergic rhinitis or chronic sinusitis. Mucosal abnormalities of sinonasal cavity may influence lower respiratory responses in patients with asthma. We experienced a case of 72-year-old woman with asthma, who had dyspnea on exertion and a large volume of expectoration of more than 100m? a day. Furthermore she had nasal symptoms (nasal obstruction and rhinorrea) with prominent post-nasal discharge. Computed tomography (CT) scans of sinonasal cavity revealed marked thickness of nasal mucosa. Although her asthma symptoms such as wheezing and dyspnea improved by administration of bronchodialators, antiallergic agent, and beclomethason di isocyanate (BDI) accompanied with spa therapy after admission, the volume of expectoration revealed no decrease and her peak expiratory flow (PEF) didn't increase. The volume of expectoration and the PEF showed marked improvement after starting of intranasal glucocorticoid therapy. It is suggested from her clinical course that treatment with intranasal glucocorticoids is very important in asthmatic patients with mucosal abnormalities of sinonasal cavity. en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=7 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=rhinitis (鼻炎) kn-keyword=rhinitis (鼻炎) en-keyword=intranasal steroid therapy (鼻腔内吸入ステロイド療法) kn-keyword=intranasal steroid therapy (鼻腔内吸入ステロイド療法) en-keyword=expectoration (喀痰排出) kn-keyword=expectoration (喀痰排出) en-keyword=peak expiratory flow (ピークフロー) kn-keyword=peak expiratory flow (ピークフロー) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=52 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Alcohol-induced pancreatitis kn-title=アルコール性膵炎 en-subtitle= kn-subtitle= en-abstract=This paper is to review the literature on the epidemiology, clinical pictures and etiopathogenesis of alcohol-induced pancreatitis (AIP). The incidence of AIP has been increasing worldwide, paralleling the increase in alcohol consumption. AIP manifests itself following a longterm consumption of large amounts of alcohol. There is no known threshold value of alcohol consumption in terms of the risk of developing AIP, although the logarithm of the risk of developing AIP is lineally correlated with the amount of alcohol intake. Why some alcoholics develop pancreatitis whereas others with equal consumption of ethanol are spared remains to be explained. Therefore, two additional factors are considered to play important roles in developing AIP : genetic predisposition and diet. The majority of AIP IS chronic pancreatitis (AICP), although a minority can be acute pancreatitis (AIAP). AIAP shows somewhat higher morbidity and mortality than the common variety of acute pancreatitis. If recovered from an attack, AIAP shows morphological and functional restoration. AICP manifests itself with an acute attack of abdominal pain, insidious onset of abdominal pam, or a pain-free variety. An acute attack in AICP resemble that m AIAP ; often these two can be differentiated only by follow-up studies. AICP shows no morphological and functional restoration, and often shows progressive deterioration. Abdominal pain with elevated serum pancreatic enzymes is a predominant clinical picture m the early stage of AICP, whereas in the late stage symptoms and signs deriving from exocrine insufficiency (maldigestion) and endocrine insufficiency (pancreatic diabetes) begin to dominate the clinical pictures. AICP is in the more advanced stage and shows more complications than nonalcoholic chronic pancreatitis at the time of diagnosis. In addition, AICP shows more rapid progress and higher morbidity and mortality. The incidence of microangiopathy in pancreatic diabetes resemble that in primary diabetes, being higher in patients with a longer history of diabetes, those on insulin treatment and those under poorer control. Main causes of death are development of cancer in the upper respiratory and gastrointestinal tract and diabetic complications (hypoglycemic shock, renal failure, and intractable pneumonia), and acute attack of pancreatitis leads to death less frequently. Ductal-Plug theory and classical Toxic-Metabolic theory are most popular to explain the pathogenesis of AIP ; however, increasing evidence has been reported that oxygen free radicals and intracellular activation of zymogens by lysosomal enzymes may be involved in the pathogenesis. kn-abstract=膵炎のうちもっとも頻度が高いアルコール性膵炎（AIP）の疫学，臨床像および発生機序に関する従来の知見を総括した。AIPの大多数は慢性膵炎である。通常は長期にわたる多量の飲酒を背景に発症するが，遺伝的素因および食事因子も重要な役割を演じる。発症初期には血中膵酵素の上昇をともなう腹痛が病像を支配するが，進展すると膵外分泌不全による消化吸収障害と膵内分泌不全による糖尿病が病像を支配するようになる。アルコール性慢性膵炎は非アルコール性慢性膵炎にくらべて確診時にすでに進展した症例が多く，合併症が多く，進行が早く，予後が悪い。死亡の主たる原因は癌の併発と糖尿病の合併症で，膵炎の急性増悪発作がこれにつぐ。併発する癌のなかでは膵癌よりもむしろ上部気道および上部消化管の癌が多い。発生機序としてはDuctal−Plug説とToxic−Metabolic説が有力であるが，最近は細 胞内膵酵素活性化説とFree　Radical説も注目をあびている。 en-copyright= kn-copyright= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=1 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=4 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=lzushiMichihiro en-aut-sei=lzushi en-aut-mei=Michihiro kn-aut-name=出石通博 kn-aut-sei=出石 kn-aut-mei=通博 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=アルコール性膵炎 (Alcohol−induced pancreatitis) kn-keyword=アルコール性膵炎 (Alcohol−induced pancreatitis) en-keyword=慢性膵炎 kn-keyword=慢性膵炎 en-keyword=急性膵炎 kn-keyword=急性膵炎 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=50 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=中高年発症型喘息患者におけるIgE系アレルギー反応の加令による変化 kn-title=Age-related changes of IgE-mediated allergic reaction in patients with late onset asthma. en-subtitle= kn-subtitle= en-abstract=発症年令が40才以上の中高年発症型喘息患者におけるIgE系アレルギー反応の加令による変化について検討を加えた｡1.発症年令が40から49才と60才以上の患者では,50から59才の患者に比して血清IgE値が300IU/m?以上の高値を示す頻度が高い傾向が見られた。2.ダニ,ゴキブリに対するRAST陽性率は発症年令が50から59才の患者に比して,40から49才と60才以上の患者で高値を示した｡一方,カンジダに対するRAST陽性率は,発症年令が40から49才と60才以上の患者に比して,50から59才の患者で高値を示した｡3.発症年令が50から59才の患者では,他の発症年令の患者に比べて,重症例が多く,軽症例が少ない傾向が見られた｡以上の結果から,発症年令が50から59才の患者のIgE系アレルギー反応は若年発症型喘息患者と異なり,発症年令が40から49才と60才以上の患者のIgE系アレルギー反応は若年発症型喘息患者と 類似することが示唆された｡ kn-abstract=Age-related changes in IgE-mediated allergic reaction were examined in patients with late onset asthma, whose asthma occured over the age at onset of 40. 1. The number of patients with a high serum IgE level over 3001U/m? was larger in those between the ages at onset of 40 and 49 and over age at onset 60 than in those between the ages at onset 50 and 59. 2. A positive RAST score to Hdm and cockroach allergens was more frequently found in patients between 40 and 49 and over age 60 at onset compared to those between 50 and 59 at onset. In contrast, the number of patients with a positive RAST to Candida was larger in those between 50 and 59 at onset than in those of between 40 and 49 and over 60 at onset. 3. Severe asthma was more frequently and slight asthma was less frequently observed in patients between 50 and 59 at onset than in those of the other age at onset groups. These results suggest that IgE-mediated allergic reaction in patients between the ages at onset of 50 and 59 is different from that in those with early onset asthma, and that the reaction in patients between the ages at onset 40 and 49 and over 60 resembles to the reaction in those with early onset asthma. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=IgE kn-keyword=IgE en-keyword=RAST kn-keyword=RAST en-keyword=吸入抗原 (inhalant Allergen) kn-keyword=吸入抗原 (inhalant Allergen) en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=加令 (aging) kn-keyword=加令 (aging) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=28 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ia型(単純気管支れん縮型)喘息における気道過敏性について…年齢および気管支肺胞洗浄液中の細胞成分との関連について kn-title=Bronchial hyperresponsiveness in type Ia (simple bronchoconstriction) asthma Relationship to patient age and the proportions of bronchoalveolar cells en-subtitle= kn-subtitle= en-abstract=気管支喘息患者Ia型(単純気管支れん縮型)39人(Ia-1型25人,Ia-2型14人)の気道過敏性を年齢,呼吸機能検査,気管支肺胞洗浄液(BAL)中の細胞成分と関連で検討を行った｡1.BAL液中の好酸球の比率はIa-1型に比べIa-2型で優位に高値であった｡2.メサコリンに対しての過敏性はIa-1型とIa-2型とで差を認めなかった｡3.気道過敏性はどちらの病型においても年齢にともなって減弱する傾向にあったが,一秒率及びBAL液中の好中球,リンパ球の比率とは相関しなかった｡4.メサコリンに対しての気道過敏性はIa-1型,Ia-2型ともにBAL液中の好酸球の比率が増加するにしたがって亢進した｡以上より単純気管支れん縮型(Ia型)の気管支喘息患者の気道過敏性はその年齢,BAL液中の好酸球の比率に相関することが示唆された｡ kn-abstract=Bronchial hyperresponsiveness was examined in relation to age, ventilatory function, and the proportion of bronchoalveolar lavage (BAL) cells in 39 patients with type Ia asthma (simple bronchoconstriction) (25 with type Ia-1 and 14 with type Ia-2), classified by clinical symptoms. 1. The proportion of BAL eosinophils was significantly higher in type Ia-2 than that in type Ia-1 asthma patients. 2. Bronchial reactivity to methacholine was not different between type Ia-1 and type Ia-2 asthma patients. 3. Bronchial hyperreactivity tended to decrease as patient age was higher in both types of asthma. Neither ventilatory function (FEV1.0%) nor the proportions of BAL lymphocytes and neutrophils was not correlated with bronchial hyperresponsiveness in both types of asthma. 4. Bronchial reactivity to methacholine more dereased with the increase in the proportion of BAL eosinophils in both type Ia-1 and Ia-2 asthma patients. The results show that bronchial hyperresponsiveness in patients with type Ia asthma is correlated to patients age and the proportion of BAL eosinophils. en-copyright= kn-copyright= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=7 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=Bronchial hyperresponsiveness kn-keyword=Bronchial hyperresponsiveness en-keyword=Type Ia asthma kn-keyword=Type Ia asthma en-keyword=Patient age kn-keyword=Patient age en-keyword=BAL eosinophiIs kn-keyword=BAL eosinophiIs END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=8 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺活量(FVC)低値を示す気管支喘息の臨床的特徴 kn-title=Clinical features of asthma patients with a low % FVC. In relation to clinical asthma type and disease severity. en-subtitle= kn-subtitle= en-abstract=% 肺活量が75%以下の低値を示す気管支喘息について,その臨床的特徴を,臨床病型や重症度との関連のもとに検討した｡1.% 肺活量と年齢との間には関連は見られなかった｡2.% 肺活量と臨床病型との問には有意の関連が見られ,U型喘息(細気管支閉塞型)における% 肺活量は,Ia-1型やIa-2型などの単純性気管支攣縮型に比べ,有意に低い値を示した｡3.% 肺活量はまた喘息の重症度と有意の関連を示した｡これらの症例では,喘息の重症度が増すにつれて,% 肺活量は減少する傾向が見られた｡4.これら症例の低値を示す% 肺活量は,治療(複合温泉療法)により改善される傾向が見られた｡以上の結果より,これらの症例(% 肺活量が75%以下)では,% 肺活量と喘息の重症度との間にある程度の関連があることが明らかになった｡ kn-abstract=Clinical features of asthma patients with a low % FVC (<75%) were studied in relation to clinical asthma type and disease severity. 1. The value of % FVC was not related to patient age. 2. A significant association between % FVC value and clinical asthma type was found. The value of % FVC was significantly lower in subjects with type U asthma (bronchiolar obstruction) than in those with type Ia-1 and type Ia-2 (simple bronchoconstriction) (p<0.001). 3. % FVC value significantly correlated with disease severity. The value in the subjects tended to decrease as their asthma conditions were more severe. 4. The % FVC value in the subjects was improved after treatment (complex spa therapy). These results demonstrate that a significant correlation is present between low % FVC and disease severity in asthma patients with a low % FVC. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=7 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=% FVC低値 (Low % FVC) kn-keyword=% FVC低値 (Low % FVC) en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=臨床病型 (Clinical asthma type) kn-keyword=臨床病型 (Clinical asthma type) en-keyword=重症度 (asthma severity) kn-keyword=重症度 (asthma severity) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=94 end-page=98 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Endoscopic aspiration of pure pancreatic juice is useful in diagnosis and treatment of chronic pancreatitis. kn-title=慢性膵炎診療における内視鏡的純粋膵液採取法の意義 en-subtitle= kn-subtitle= en-abstract=Endoscopical aspiration of pure pancreatic juice is useful in following aspects. Firstly, intraductal secretin test by using this method can be substituted for duodenal secretin test, which is a gold standard examination for estimation of exocrine pancreatic function. In addition, endoscopic aspiration of protein pluge eliminates abdominal pain of some painful patients with chronic pancreatitis. Cytological examination, determination of tumor marker, and detection of oncogene in the obtained pancreatic juice are complementary diagnostic approach to pancreatic cancer, which must be differentially diagnosed from chronic pancreatitis. kn-abstract=内視鏡的純粋膵液採取法の慢性膵炎診療における意義を検討した｡本法を用い,セクレパン100単位静注後10分間膵液を採取するintaraductal secretin test(IDST,膵管内セクレチン試験)はこれまで膵外分泌機能検査のgold standardである十二指腸液を採取するセクレチン試験に代用ができ,しかも10分間の採取時間で終了する利点を有する｡本法を施行することにより,蛋白栓が除去され,痔痛の消失に有用である｡また,慢性膵炎と鑑別を要する膵癌を除外診断するために,本法によって採取した膵液の細胞診,腫瘍マーカー,癌遺伝子の検出は有用である｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=3 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=4 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=9 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学中央検査部 affil-num=2 en-affil= kn-affil=岡山大学中央検査部 affil-num=3 en-affil= kn-affil=岡山大学中央検査部 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=勝山病院 affil-num=10 en-affil= kn-affil=岡山赤十字病院 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=膵液 (pancreatic juice) kn-keyword=膵液 (pancreatic juice) en-keyword=内視鏡 (endoscopy) kn-keyword=内視鏡 (endoscopy) en-keyword=膵外分泌機能検査 (exocrine pancreatic function test) kn-keyword=膵外分泌機能検査 (exocrine pancreatic function test) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=64 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of eosinophilic gastroenteritis with stenosis in the colon kn-title=大腸の全周性狭窄を呈した好酸球性胃腸炎の1例 en-subtitle= kn-subtitle= en-abstract=We report a case of eosinophilic gastroenteritis with a stenosis in the transverse colon. A patient, 54 year-old-woman, presented to our clinic with abdominal pain and diarrhea. Esophagogastric endoscopy and biopsy were normal. Contrast barium enema examination and colonic endoscopy showed a stenotic segment in the transverce colon. Biopsy specimens obteind from the stenotic segment revealed moderate eosinophilic infiltration in the colonic mucosa. Oral intake of sea shells exacerbated her symptoms. Avoiding sea shells has resulted in the disappearance of symptoms and peripheral blood eosinophilia. The present case was discussed in comparison with the 124 cases heretofore reported in Japan. kn-abstract=大腸に全周性狭窄をきたした好酸球性胃腸炎の1例を報告した｡症例は54才の女性で,腹痛と下痢を主訴に来院した｡上部消化管検査では異常を認めなかったが,下部消化管造影検査と大腸内視鏡検査で横行結腸の全周性狭窄を認め,生検にて大腸粘膜の好酸球浸潤を認めた｡貝料理の摂取にて腹痛発作が出現したが,原因抗原は同定できなかった｡貝類の摂取を避けることにより,症状は消失し,末梢血液中の好酸球増多は消失した｡本邦ではこれまでに124例 の報告があるが,大腸に全周性の狭窄をきたす症例は稀であり,文献的考察を加え報告する｡ en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=4 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=好酸球性胃腸炎 (eosinophilic gastroenteropathy) kn-keyword=好酸球性胃腸炎 (eosinophilic gastroenteropathy) en-keyword=大腸 (colon) kn-keyword=大腸 (colon) en-keyword=狭窄 (stenosis) kn-keyword=狭窄 (stenosis) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=59 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=慢性膵炎患者の全消化管通過に関する研究 kn-title=Studies on whole gut transit in chronic pancreatitis patients en-subtitle= kn-subtitle= en-abstract=慢性膵炎の患者の自覚症状や消化不良には消化管の通過異常が関与している可能性がある｡慢性膵炎患者15例と対象群17例で全消化管通過を測定した｡さらに慢性膵炎患者は自律神経機能について評価した｡全消化管通過は慢性膵炎患者は対象群より早いことが示された｡しかしその機序として推定された自律神経機能異常の有無では全消化管通過に差は認められず,慢性膵炎の消化管機能異常の原因は自律神経異常ではないと推定された｡ kn-abstract=Abnormalities of whole gut transit could contribute to the maldigestion and　digestive symptoms of chronic pancreatitis patients. Whole gut transit was measured by radiopaque markers method. Fifteen chronic pancreatitis patients (2 females, 13 males; age range 40-78 years) and 17 controls (4 females, 13 males, 32-73 years) were studied. Additionally, we also looked for evidence of autonomic neuropathy in the chronic pancreatitis patients by using cardiovascular tests. In chronic pancreatitis, whole gut transit was shorter than controls. These abnormalities were not influenced by the degree of autonomic neuropathy. We conclude that whole gut transit is shorter in chronic pancreatitis patients. en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=全消化管通過 (Whole gut transit) kn-keyword=全消化管通過 (Whole gut transit) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=22 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息におけるアレルギー性鼻炎と花粉抗原に対するIgE抗体 kn-title=IgE antibodies against pollinosis-inducing allergens in asthma patients with and without allergic rhinitis en-subtitle= kn-subtitle= en-abstract=気管支喘息53例を対象に,吸入抗原に対するIgE抗体とアレルギー性鼻炎の合併の有無との関連について若干の検討を加えた｡対象53例中20例(37.7%)にアレルギー性鼻炎の合併が見られた｡ 1.喘息+アレルギー性鼻炎の合併は,0-39才の年齢層で最も多い傾向であったが,一方,喘息単独は60才以上の症例に多く見られた｡2,IgE抗体の陽性率は,それぞれHDm50.9%,ごきぶり 24.5%,カンジダ26.4%であった｡これら抗原のRAST陽性率は,アレルギー性鼻炎合併例と非合併例の問に有意の差は見られなかった｡3.スギおよびイネ科の花粉に対するRAST陽性率はアレルギー性鼻炎合併例で(スギ42.9%,イネ科18.5%),非合併例に比べ(28.6%と3.7%)高い傾向が見られたが,両群間に有意の差は見られなかった｡4.花粉抗原によるアレルギー性鼻炎(花粉症)の頻度は9.4% (53例中5列)とあまり高くはなかった｡以上の結果より,気管支喘息患者でしばしばアレルギー性鼻炎の合併が見られること,(しかし, 花粉症は少ない),そして,スギおよびイネ科の花粉に対するIgE抗体は,アレルギー性鼻炎の合併のない症例においても観察されること,などが明らかにされた｡ kn-abstract=IgE antibodies against inhalant allergens were estimated in 53 patients with bronchial asthma in relation to allergic rhinitis. Of them, 20 patients (37.7%) had allergic rhinitis. 1. Asthma + allergic rhinitis were often observed in patients between the ages of 0 and 39. In contrast, asthma alone in those over age 60. 2. A RAST score was positive in house dust mite (HDm)(50.9%), cockroach(24.5%), and Candida (26.4%) in these patients, and the positive rate was not different between patients with and without allergic rhinitis. 3. The frequency of positive RAST against Japanese cedar and rice plants was higher in patients with allergic rhinitis (42.9% and 18.5%) than in those without allergic rhinitis (28.6 and 3.7%), however, the each positive rate or RAST against the two allergens was not significantly different between those with AR and without AR. 4. The number of patients with AR induced by pollen alone (pollinosis) was not large ( 5/53, 9.4%) in the patients with asthma. It was clarified from the results that allergic rhinitis was often observed in asthma patients, but not pollinosis. and that IgE antibodies against Japanese cedar and rice plants were found even in patients without AR. en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=5 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=6 ORCID= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=岩垣尚史 kn-aut-sei=岩垣 kn-aut-mei=尚史 aut-affil-num=7 ORCID= en-aut-name=YamamotoKazuhiko en-aut-sei=Yamamoto en-aut-mei=Kazuhiko kn-aut-name=山本和彦 kn-aut-sei=山本 kn-aut-mei=和彦 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=allergic rhinitis kn-keyword=allergic rhinitis en-keyword=IgE antibodies kn-keyword=IgE antibodies en-keyword=house dust mite kn-keyword=house dust mite en-keyword=Japanese cedar kn-keyword=Japanese cedar END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=82 end-page=87 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=膵癌における癌遺伝子および癌抑制遺伝子 kn-title=Oncogenes and tumor suppressor genes in pancreatic cancer en-subtitle= kn-subtitle= en-abstract=膵癌の予後は惨憺たるものである｡一方で,最近の分子生物学の分野での研究の進歩により,遺伝子レベルでの異常が膵癌では数多く存在することも明らかになってきた｡膵癌の予後を改善するために,発展が期待される膵癌における遺伝子診断や遺伝子治療に向けて現在までの膵癌で明らかになった癌遺伝子(k-ras,erbB-2,Met),癌抑制遺伝子(p53,p16,APC,DDC)について,概説した。 kn-abstract=Recent advances in molecular biology have revealed that a number of oncogenes (K-ras, erbB-2, and Met) and tumor suppressor genes (p53, p16, APC, and DCC) contribute to the development of pancreatic cancer. This paper reviewed the present knowledge of oncogenes and tumor suppressor genes relevant to pancreatic cancer. Further studies on molecular alterations in pancreatic cancer may lead to a better understanding of tumor biology, offering a possibility of development of new diagnostic and therapeutic approaches in the future. en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=6 ORCID= en-aut-name=YokoyamaMotohiro en-aut-sei=Yokoyama en-aut-mei=Motohiro kn-aut-name=横山元浩 kn-aut-sei=横山 kn-aut-mei=元浩 aut-affil-num=7 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=8 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=勝山病院 affil-num=7 en-affil= kn-affil=岡山赤十字病院 affil-num=8 en-affil= kn-affil=岡山赤十字病院 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=Pancreatic cancer kn-keyword=Pancreatic cancer en-keyword=oncogene kn-keyword=oncogene en-keyword=tumor suppressor gene kn-keyword=tumor suppressor gene en-keyword=genetic mutation kn-keyword=genetic mutation END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=68 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=サーモグラフィーによる体表面温度の測定 2.温水負荷の効果 kn-title=Evaluation of Body Surface Temperature by Thermography 2. Effect of Pre-loading with Hot Water en-subtitle= kn-subtitle= en-abstract=下肢に冷感ならびにしびれ感または疼痛を訴える患者41症例についてサーモグラフィーを用いて体表面温度を測定した｡測定で得られた結果は回復率として数量化して表示された｡回復率の算出方法は回復率=[冷水負荷後の特定温度T℃以上の体表面温度のサーモグラフィーのPixelの総数]÷[温水負荷前の特定温度T℃以上の体表面温度のサーモグラフィーのPixelの総数]× 100%で求めた｡サーモグラフィーで得られた結果と画像処理の過程で用いられた,26℃,27℃,28℃の3つの異なる特定温度T℃ との関連について検討を行なった｡その結果,回復率は特定温度T℃に影響を受けやすいことが明らかとなった｡下肢の体表面温度の低い臨床症例においては27℃の条件が適当と考えられた｡前述の41症例中の18症例の糖尿病患者について検討を行なった｡そのサーモグラフィーの結果は,比較的回復率の高い(80%〜100%)群の6症例と比較的回復率の低い(0%〜19%)群の10症例の2群に別れた｡わずかに残り2症例が20%から79%の間であった｡下肢の症状が気温の低い時期に出親しやすいためにサーモグラフィーの検査を冬期に行なう必要性が高まった｡しかし,天候の影響を受けやすいために冷水負荷前の測定領域の下肢が冷えすぎているために20℃の室温に15分間の安静時間では体表面温度が十分に暖まることが出来ず,27℃以上の領域として測定範囲全体を観察できない 問題に直面した｡この間温点を解決する手段として36℃の温水に5分間下肢を入れて暖める温水負荷を加えることにした｡そこで, 温水負荷を行なった症例30症例について,温水負荷を行なう前(室温)の回復率と温水負荷を行なった後の回復率について比較検討を行なったところ,20%にあたる6症例において温水負荷を行なわなかった場合に20%以上の回復率の過剰評価が認めら れた｡温水負荷を行なうことにより年間を通じて天候の影響を最小限にすることが可能となり,この結果,長期間の内服薬の末梢循環に及ぼす影響の測 定を行なった場合に,季節の影響を最小限にしてサーモグラフィーにより回復率を用いて数値化された測定結果を検討することが可能となった｡具体的に末梢循環の改善に薬効が有ると言われている薬剤であるベラプロストおよびサルポグレラートを3ヵ月間内服した場合の前後のサーモグラフィーで得られた回復率について検討を行なった｡その結果はベラプロストにおいては,6.9%から41.9%に上昇または回復率の6.1倍の上昇を認めた。サルポグレラートにおいては,1.9%から17.3%に上昇または回復率の9.1倍の上昇を認めた。以上より,温水負荷を加えたサーモグラフィーの測定結果の数値化は下肢に症状の有る患者の末梢循環の評価ならびに薬効の評価の比較に有用であることが表わされた｡ kn-abstract=The body surface temperature of 41 patients suffering coldness, numbness or pain in their feet was examined using thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as: Recovery ratio =[Total counts of thermography (Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). Three different baseline temperatures, 26℃. 27℃ and 28℃, were used in processing the thermographic results into pictures. The recovery ratio was susceptible to temperature, and we recommend a baseline temperature limitation of 27℃ for clinical study. A bi-modal distribution of recovery ratio was observed in 18 patients with diabetes mellitus. One group (6 subjects) had high recovery ratio between 80%-100%, and another group (10 subjects) had a low recovery ratio between 0%-19%. The results of thermography were also influenced by weather. To reduce the effect of outside temperature, we used pre-loading with hot water at 36℃ for 5 min (hot loading).　A large difference in　recovery ratio between presence and absence of hot loading was observed in 6 of the 30 subjects. The difference was over-estimated in more than 20% of recovery ratio without hot loading as compared with hot loading in these 6 subjects. The effect of drugs on peripheral circulation, such as beraprost sodium and sarpogrelate hydrochloride, was clear and quantified using thermography under these conditions of hot loading. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部第一内科 en-keyword=サーモグラフィー (thermography) kn-keyword=サーモグラフィー (thermography) en-keyword=糖尿病 (diabetes mellitus) kn-keyword=糖尿病 (diabetes mellitus) en-keyword=末梢循環 (peripheral circulation) kn-keyword=末梢循環 (peripheral circulation) en-keyword=冷水負荷 (cold loading) kn-keyword=冷水負荷 (cold loading) en-keyword=温水負荷 (hot loading) kn-keyword=温水負荷 (hot loading) END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=28 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者における努力肺活量(% FVC)の低下と気道炎症ならびに臨床病型との関連 kn-title=Correlation between decrease in % FVC and airway inflammation in patients with asthma, classified by clinical symptoms en-subtitle= kn-subtitle= en-abstract=努力肺活量(% FVC)低値を示す気管支喘息の臨床病態を明らかにするために気道炎症ならびに臨床病型との関連について検討を行った｡% FVCが80%未満の気管支喘息患者32名を対象として,スパイロメトリー,気管支肺胞洗浄(BAL)を施行し,臨床病態を解析し,治療効果の評価を行なった｡1.対象中24名(75%)の患者がステロイド依存性重症難治性喘息であった｡2.細気管支閉塞型喘息患者において,% FVC値の有意の低下が認められ,BAL液中のリンパ球の減少と好中球の増加が認められた｡3.FVC値,FEV1.0億の治療による改善は,BAL液中好酸球の増加を示す過分泌型喘息においては認められが,BAL液中好中球の増加を示す細気管支閉塞型喘息においては認められなかった｡ 以上より喘息患者における% FVC値の低下は気道炎症と関連しており,細気管支閉塞型喘息における治療による可逆性は著しく低下していることが示唆された｡ kn-abstract=Clinical features of asthmatics with a low % FVC (<80%) were studied in relation to airway inflammation and clinical asthma types. 1. Twenty four (75.0%) of the 32 subjects with a low % FVC had steroid-dependent intractable asthma. 2. A significant association between % FVC value and clinical asthma type was found. The value of % FVC was significantly lower in subjects with type II asthma (bronchiolar obstruction), in which significantly decreased proportion of lymphocytes,and significantly increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid were observed, than in those with type la-1 (simple bronchoconstriction) with (P<0.001) and without glucocorticoid therapy (P<0.02). 3. The % FVC value was significantly improved after treatment in type lb (hypersecretion) with BAL eosinophilia, but not in those with type II with BAL neutrophilia. These results demonstrate that marked decrease of % FVC in patients with asthma correlated with airway inflammation, and that airway reversibility by medication is very low in patients with type II asthma. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=ventilatory function kn-keyword=ventilatory function en-keyword=FEV1.0 kn-keyword=FEV1.0 en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage en-keyword=bronchial reversibility kn-keyword=bronchial reversibility END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=21 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺気腫患者における吸入抗原に対するIgE抗体 kn-title=IgE antibodies against inhalant allergens in patients with pulmonary emphysema en-subtitle= kn-subtitle= en-abstract=肺気腫患者の気道病変を解析する目的で,22例の肺気腫患者を対象に,その気道反応および白血球のロイコトリエンB4,C4産生能について検討を加えた｡この際対象症例はIgE抗体の有無によってRAST陽性症例RAST陰性症例に分類された｡1.喫煙歴,平均CT値,high resolution computed tomography(HRCT)上の-950HU以下の% low attenuation area(% LAA),DLcoなどの値は,いずれも対象症例が高度な気腫化病変を有してい ることを示した｡2.血清IgE値は,RAST陽性例で陰性例に比べ有意の高値を示した｡3.β受容体刺激薬吸入後のFEV1.0の増加は,RAST陽性例で陰性例に比べ高度であった｡そして,吸入後のFEV1.0が15%以上の増加を示した症例は,RAST陽性例では9例中4例(44.4%),陰性例では12例中2例(16,7%)であった｡4.白血球のLTC4産生量は,RAST陽性例で陰性例に比べ有意に高い値であったが,LTB4産生は両者間に有意の差は見られなかった｡以上の結果より,IgEにmediateされるアレルギー反応が,肺気腫患者 の気道反応に関与している可能性が示唆された。 kn-abstract=To analyze the pathophysiological changes ot the airways in emphysema, bronchial responsiveness and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leucocytes were examined in 22 patients with emphysema. The subjects were divided into two groups according to the presence or absence of IgE antibodies against inhalant allergens; RAST positive group and RAST negative group. 1. Smoking history, mean CT number and mean maximum % low attenuation area (% LAA) <-950HU of the lung on high resolution computed tomography (HRCT), and DLco value suggested that there were emphysematous changes of the lung in all subjects. However, these findings were not different between the two groups. 2. The level of serum IgE was significantly higher in RAST positive group than in RAST negative group. 3. The mean % increase in FEV1.0 after inhalation of β-agonists was higher in RAST positive group than in RAST negative group. The % increase more than 15% was found in 4 of the 9 subjects (44.4%) in RAST positive group and 2 of the 12 (16.7%) in RAST negative group. 4. The generation of LTC4 by leucocytes was significantly higher in RAST positive group than in RAST negative group (p<0.01). The generation of LTB4 was not significantly different between the two groups. The results suggest that IgE-mediated allergy participates in the bronchial responsiveness of patients with emphysema. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=5 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=6 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=7 ORCID= en-aut-name=YumotoEiichiro en-aut-sei=Yumoto en-aut-mei=Eiichiro kn-aut-name=湯本英一郎 kn-aut-sei=湯本 kn-aut-mei=英一郎 aut-affil-num=8 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=11 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=12 ORCID= en-aut-name=HasegawaHarumi en-aut-sei=Hasegawa en-aut-mei=Harumi kn-aut-name=長谷川晴巳 kn-aut-sei=長谷川 kn-aut-mei=晴巳 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=13 en-affil= kn-affil=鳥取市立病院内科 en-keyword=emphysema kn-keyword=emphysema en-keyword=bronchial responsiveness kn-keyword=bronchial responsiveness en-keyword=FEV1.0 kn-keyword=FEV1.0 en-keyword=LTB4 kn-keyword=LTB4 en-keyword=LTC4 kn-keyword=LTC4 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=15 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺気腫患者におけるロイコトリエンB4,C4産生能と高分解能CTによる平均CT値との関連 kn-title=Association of the mean CT number by high resolution computed tomography (HRCT) with generation of leukotrienes B4 (LTB4) and C4 (LTC4) in patients with pulmonary emphysema en-subtitle= kn-subtitle= en-abstract=肺気腫患者17名を対象として,カルシウムイオノフォアA23187による末梢血白血球からのロイコトリエンB4(LTB4), ロイコトリエンC4(LTC4)の産生能の検討を行った｡対象は高分解能CTによる平均CT値によってA(<940HU), B(-940≦,<-930HU),C(-930HU≦)の3群に分類した｡1.% FVC,FEV1.0%,% DLcoが低下するにつれて平均CT値が低下する傾向が見られた｡% FVC値はC群に比較して,A群において有意に低値を示した(p<0.05)｡2.LTB4とLTC4の産生能は健常人に比較して,肺気腫患者において有意に高値を示した(LTB4;p<0.05,LTC4;p<0.05)。3.肺気腫患者におけるLTB4とLTC4の産生能は平均CT値が上昇するにつれて(軽症症例ほど)高値を示した｡またLTC4産生能はC群(早期肺気腫症例)においてA群(進行肺気腫症例)に比して有意に高値を示した｡以上より肺気腫におけるLTB4,LTC4産生能は進行例に比較すると,軽･中等症例において高値であることが示唆された｡ kn-abstract=The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leukocytes stimulated with Ca ionophore A23187 was examined in 17 patients with pulmonary emphysema. They were divided into three groups according to the mean CT number; A (<-940 HU), B (-940 ≦, <-930 HU), and C (-930 HU ≦ ).1. The values of FVC (% predicted), FEV1.0% and DLco (% predicted) showed a tendency to decrease as the mean CT number was smaller. The value of % FVC was significantly lower in patients with group A than in those with group C (p<0.05). 2. The generation of both LTB4 and LTC4 was significantly higher in patients with emphysema compared to the generation in healthy subjects (LTB4;p<0.05, LTC4;P<0.05). 3. The generation of LTB4 and LTC4 in patients with emphysema was higher as the mean CT number was larger (severity of the disease become less). The LTC4 production was significantly higher in patients with group C(mild or moderate type of emphysema) than in those with group A(advanced type of emphysema). These results suggest that the generation of LTB4 and LTC4 is higher in patients with mild or moderate type of emphysema than in those with advanced type of the disease. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=5 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=6 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=7 ORCID= en-aut-name=YumotoEiichiro en-aut-sei=Yumoto en-aut-mei=Eiichiro kn-aut-name=湯本英一郎 kn-aut-sei=湯本 kn-aut-mei=英一郎 aut-affil-num=8 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=HasegawaHarumi en-aut-sei=Hasegawa en-aut-mei=Harumi kn-aut-name=長谷川晴巳 kn-aut-sei=長谷川 kn-aut-mei=晴巳 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=鳥取市立病院内科 en-keyword=emphysema kn-keyword=emphysema en-keyword=mean CT number kn-keyword=mean CT number en-keyword=LTB4 kn-keyword=LTB4 en-keyword=LTC4 kn-keyword=LTC4 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=9 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における末梢血白血球のロイコトリエンB4およびC4産生能 kn-title=Leukotrienes B4 and C4 generation by peripheral leucocytes in patients with asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息16例(アトピー型喘息8例,非アトピー型喘息8例)を対象に,Ca ionophore A23187 刺激時の末梢血白血球のロイコトリエンB4(LTB4)およびC4(LTC4)産生能について検討した｡1.LTB4産生能は,喘息症例と健康人 の間に有意の差は見られなかった｡LTC4産生能は,健康人に比べ喘息症例で有意に高い傾向が見られた｡また,喘息症例では,非発作時(23.3±25.9ng/5xl0(6)cells)に比べ発作時(58.4±38.5ng/5xl0(6)cells)に有意に高い値を示した(p<0.05)。アトピー型喘息では,非発作時(40.4±27.2mg/5xl0(6)cells) に比べ発作時(84.7±35.4ng/5xl0(6)cells) に有意の高値を示したが(p<0.02),LTB4 産生に関しては両者間に有意の差は見られなかった｡3.非アトピー型喘息においても同様,非発作時(12.2±3.2ng/5xl0(6) cells) に比べ発作時 (32.2±26.3ng/5xl0(6)cells)で有意の高値であったが(P<0.05), LTB4 では有意差は見られなかった｡4.LTC4産生能は,発作時､非発作時とも,アトピー型喘息で非アトピー型喘息に比べ有意に高いことが示唆された｡以上の結果より,喘息症例における白血球のLTC4産生能はIgE にmediateされる反応と密接な関連がある可能性が示唆された｡ kn-abstract=The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 16 patients with asthma (8 with atopic and 8 with nonatopic asthma) and 12 healthy controls. 1. The LT84 generation by leucocytes was not significantly different between patients with asthma and healthy controls. The generation of LTC4 was significantly larger in patients with asthma than in healthy controls. The LTC4 generation was also significantly larger in patients with attacks (58.4 ± 38.5 ng/5x10(6) cells) than in those without attacks (23.3 ± 25.9 ng/5x10(6) cells)(p<0.05). 2.ln atopic asthma, the LTC4 production was significantly larger in patients with attacks (84.7 ± 35.4 ng/5x10(6) cells) compared to the production in those without attacks (40.4 ± 27.2 ng/5x10(6) cells)(p<0.02). However, the production of LTB4 was not significantly different between attack and attack-free stages. 3. In nonatopic asthma, the LTC4 production was also significantly higher in patients with attacks (32.2 ± 26.3 ng/5x10(6) cells) than in those without attacks (12.2 ± 3.5 ng/5x10(6) cells)(p<0.05). However, the LTB4 production was not significantly different between attack and nonattack stages. 4. The LTC4 production was significantly larger in atopic asthmatics compared to the production in nonatopic subjects both in attack and nonattack stages. These results suggest that the generation of LTC4 by leucocytes of patients with asthma is closely related to IgE-mediated reaction and asthma attacks. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=8 ORCID= en-aut-name=YumotoEiichiro en-aut-sei=Yumoto en-aut-mei=Eiichiro kn-aut-name=湯本英一郎 kn-aut-sei=湯本 kn-aut-mei=英一郎 aut-affil-num=9 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=10 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=11 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=LTB4 kn-keyword=LTB4 en-keyword=LTC4 kn-keyword=LTC4 en-keyword=IgE-mediated reaction kn-keyword=IgE-mediated reaction en-keyword=asthma attacks kn-keyword=asthma attacks END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical significance of spa therapy in the treatmentof patients with chronic obstructive pulmonary disease (COPD). A study on 511 patients with COPD admitted for last 5 years kn-title=慢性閉塞性呼吸器疾患に対する温泉療法の臨床的評価.最近5年間(1993年- 1997年)の入院症例511例を対象に en-subtitle= kn-subtitle= en-abstract=The kind of respiratory disease, age, and areas where patients came from were analyzed in 511 patients with chronic obstructive pulmonary disease (COPD) admitted at Misasa Medical Branch for last 5 years from 1993 to 1997. 1.For the last 5 years 594 patients with respiratory diseases were admitted at Misasa Medical Branch. Of these patients 511 (86.0%) were those with COPD. Of the 511, 416 (81.4%) were patients with asthma, 20 with chronic bronchitis, 27 with obstructive bronchiolitis, and 48 with pulmonary emphysema. 2.The number of patients with pulmonary emphysema showed a tendency to increase in recent years. 3.Regarding the distribution of age of these patients, the number of patients over the age of 60 was larger than the number of patients under the age of 59:patients between the ages of 60 and 69 were more frequently observed in those coming from distant area (outside Tottori prefecture), and those over the age of 70 in those coming from Tottori prefecture. 4. The number of patients from distant areas (outside Tottori prefecture) was considerably larger (48.4% in 1997) compared to the number of patients from Tottori prefecture. The number of patients from Okayama, Hyogo, Osaka, Hiroshima, Yamaguchi and Ehime was predominantly larger than the number of patients from other distant areas. kn-abstract=1993年1月より1997年12月までの5ヵ年間に当院へ入院した慢性閉塞性呼吸器疾患511例を対象に,疾患の種類,年齢,地域分布などについて検討を加えた｡1.最近5年間に当院へ入院した呼吸器疾患患者は594例で,このうち,慢性閉塞性呼吸器疾患患者は511例(86.0%)であった｡これらの慢性閉塞性呼吸器疾患のなかでは,気管支喘息が416例(81.4%)と最も多く,その他.慢性気管支炎20例,閉塞性細気管支炎27例,肺気腫48例であった｡2.慢性閉塞性呼吸器疾患のなかでは,肺気腫の症例が増加する傾向が見られた｡3.慢性閉塞性呼吸器疾患の年齢別検討では,鳥取県内では,70才以上の症例が,また遠隔地(鳥取県外)では60-69才の症例の頻度が高い傾向が見られた｡4.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,その比率は1997年度で48.4%であった｡また,その分布別検討では,岡山県,兵庫県,大阪府,広島県,山口県,愛媛県からの入院患者が多い傾向が見られた｡ en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=8 ORCID= en-aut-name=YumotoEiichiro en-aut-sei=Yumoto en-aut-mei=Eiichiro kn-aut-name=湯本英一郎 kn-aut-sei=湯本 kn-aut-mei=英一郎 aut-affil-num=9 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=10 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=11 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=慢性閉塞性呼吸器疾患 (COPD) kn-keyword=慢性閉塞性呼吸器疾患 (COPD) en-keyword=気管支喘息 (bronchial asthma) kn-keyword=気管支喘息 (bronchial asthma) en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=高齢患者 (aged patients) kn-keyword=高齢患者 (aged patients) en-keyword=遠隔地 (distant area) kn-keyword=遠隔地 (distant area) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=84 end-page=87 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Interferon and pancreatitis kn-title=膵炎とインターフェロン en-subtitle= kn-subtitle= en-abstract=Pancreatitis is known to be one of the adverse effects of interferon, which has been widely used for treatment of chronic hepatitis and malignant diseases. In this paper, we reviewed pancreatitis as adverse effects of interferon and effect of interferon on the pancreas. kn-abstract=インターフェロンは慢性肝炎や悪性腫瘍の治療など,広く臨床の場に用いられるようになった｡その副作用の一つとして,膵炎があり,その多くは急性膵炎である,慢性膵炎の報告もあり,膵炎はインターフェロンを用いる場合に知っておくべき副作用である｡そこで,膵炎とインターフェロンの関係について現在までに知られている知見について概説する｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=勝山病院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=インターフェロン (interferon) kn-keyword=インターフェロン (interferon) en-keyword=急性膵炎 (acute pancreatitis) kn-keyword=急性膵炎 (acute pancreatitis) en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=79 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=臨床的および実験的側面からみた慢性膵炎とフリーラジカル kn-title=Clinical and experimental aspects of free radicals in chronic pancreatitis en-subtitle= kn-subtitle= en-abstract=慢性肺炎の発症機序は不明な点が多いが､フリーラジカルがそれに関与することが示唆する報告も多い｡しかし,その直接的な証明はなされていない｡慢性膵炎の病態にフリーラジカルがどのように関与するかを理解することは慢性膵炎の発症機序の解明の一助になると考え,臨床的および実験的側面から慢性膵炎とフリーラジカルの関係を概説した｡ kn-abstract=Free radicals have been suspected to play an important role in the pathogenicity of chronic pancreatitis. We reviewed studies on free radicals in chronic pancreatitis in both c1inical and experimental aspects. Many clinical studies have provided circumstantial evidence for the close relation between free radicals and chronic pancreatitis. However, few experimental studies in animals on relation between free radicals and chronic pancreatitis have been reported, because adequate experimental models for elucidating a pathological role of free radicals in chronic pancreatitis have not been established. The research concerning the role of free radicals in chronic pancreatitis is expected to improve our understanding the pathological mechanisms of the disease. en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=フリーラジカル (free radicals) kn-keyword=フリーラジカル (free radicals) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=36 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=サーモグラフィーによる体表面温度の測定 3.体表面温度の回復率と末消血流量との相関 kn-title=Evaluation of Body Surface Temperature by Thermography 3. Correlation between the peripheral circulation estimatedby Laser-Doppler blood flowmetry and thermography. en-subtitle= kn-subtitle= en-abstract=末梢神経障害を有する糖尿病患者の末梢循環障害の程度を数量的に検討する目的で､下肢に冷感ならびにしびれ感または疼痛を訴える糖尿病患者9症例と健常ボランティア3例の計12例(平均年齢59歳)についてサーモグラフィーを用いて体表面温度を測定した｡更に,サーモグラフィーで得られた結果と末梢皮膚血流量をレーザードプラー血流計を用いて測定して得られた結果と比較した｡サーモグラフィーによる測定で得られた結果は回復率として数量化して表示された｡回復率の算出方法は回復率= [冷水負荷後の特定温度27℃以 上の体表面温度のサーモグラフィーのPixelの総数]÷ [冷水負荷前の特定温度27℃以上の体表面温度のサーモグラフィーのPixelの総数]×100%で求めた｡レーザードプラ-血流計を用いて測定して得られた末梢血流量は左右それぞれ5カ所,計10カ所の測定値の平均で表示した｡その結果,末梢皮膚温度の回復率と末梢皮膚の血流量との問には正の相関関係(r=0.68,p<0.01)が認められた｡次に,末梢皮膚血流量について,室温20℃安静15分後,温水36℃浸水負荷10分後,冷水20℃浸水負荷30分後の異なる3条件について､またサーモグラフィーで得られた結果を,画像処理の過程で用いられた,26℃,27℃,28℃の3つの異なる特定温度との関連について検討を行なった｡対象は,下肢に冷感ならびにしびれ感または疼痛を訴える糖尿病患者16症例(平均年齢69歳,平均HbAIC9.6%)について測定した｡その結果,末梢皮膚 血流量は冷水20℃浸水負荷30分後に測定して得られた結果と,回復率は特定温度27℃で画像処理して得られた結果とが最も相関が高い(r=0.59,p=0.0002)ことが示された｡`次に,相関が高い条件は,室温20℃安静15分後に血流量を測定した場合(r=0.483,p=0.0002)であった｡そして温 水36℃浸水負荷10分後に測定して得られた結果とが最も相関関係が低い結果となった｡更に,冷水20℃浸水負荷30分後に測定して得られた結果を温水36℃浸水負荷10分後に測定して得られた結果で割った比を%で表示したところ回復率とこの比との間には正の相関関係(r=0.46,p<0.0001)が認められた｡このことから,温水36℃負荷時と,冷水20℃負荷時との差が大きい患者 において末梢皮膚温度の低下が著しいことが示された｡これまで悲観血的に測定されてきたサーモグラフィーによる末梢循環の数量的評価の試みは,レーザー血流計による結果と組み合わせることで,両者の間に正の相関関係が示されたことにより,今後,数量化された客観的評価を可能にした｡ kn-abstract=The body surface peripheral circulation in 12 cases,　including 9 patients with　diabetes mellitus who were suffering coldness, numbness or pain in their feet, and 3 healthy volunteers was examined using Laser-Doppler blood flowmetry. At the same time, the body surface temperature was estimated by thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio = [Total counts of thermography(Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). The recovery ratio and the blood flow were correlated, r=0.68, p1/2 myometrium), the accuracy was 85.0% by TV and 61.7% by TA (p<0.01). In regard to the minimum width of the intact myometrium and the thickness of the high echoic area measured by each method, significant differences were obserevd between the M2-group and the other two group by the two methods. These p-values in TV were more significant than those in TA. In evaluating the presence of cervical invasion, the accuray was 95.0% by TV, while 88.3% by TA. Thus TV was found to be more useful than TA in the evaluation of both myometrial invasion and cerical invasion. en-copyright= kn-copyright= en-aut-name=TomokuniHirotaka en-aut-sei=Tomokuni en-aut-mei=Hirotaka kn-aut-name=友國弘敬 kn-aut-sei=友國 kn-aut-mei=弘敬 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 en-keyword=子宮体癌 kn-keyword=子宮体癌 en-keyword=筋層浸潤 kn-keyword=筋層浸潤 en-keyword=頚部浸潤 kn-keyword=頚部浸潤 en-keyword=経腟走査 kn-keyword=経腟走査 en-keyword=超音波断層法 kn-keyword=超音波断層法 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=489 end-page=499 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The usefulness of transvaginal ultrasonography and MRI in endometrial carcinama : Evaluating myomertrial and cervical invasion kn-title=子宮体癌に対する経腟走査超音波断層法とMRIの有用性について―筋層浸潤と頚部浸潤の評価― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Between October, 1988 and March, 1991, twenty-mine patients with endometrial carcinoma bad both transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) performed following hysterectomy at the Departmetn of Gynecology and Obstetrics, Okayama University Medical School. The findings were compared with the pathological findings to determine the usefulness of each method. The sensitivity of dectecthing myometrial invasion was 100% by TVUS and 96% by MRI. The accuracy was 86% by each method. The depth of myometrial invasion was classified into 3 degrees [no myometrial invasion, superficial invasion (?1/2), deep invasion (>1/2)]. The correct diagnostic rate was 86% by TVUS and MRI. The minimum width and the minimum/maximum width ratio of the intact myometrium obtained by each method in the pathological deep invasion group were significantly lower than those obtained in the other two groups (p<0.01). The sensitivity, the accuracy and the specificity of detecting cervical invasion were 89%, 93% and 95% by both methods. There was no difference between TVUS and MRI for diagnosing myometrial and cerical invasion of endometrial carcinoma. en-copyright= kn-copyright= en-aut-name=YoshiharaEisuke en-aut-sei=Yoshihara en-aut-mei=Eisuke kn-aut-name=吉原英介 kn-aut-sei=吉原 kn-aut-mei=英介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 en-keyword=子宮体癌 kn-keyword=子宮体癌 en-keyword=経腟走査超音波断層法 kn-keyword=経腟走査超音波断層法 en-keyword=MRI kn-keyword=MRI en-keyword=筋層浸潤 kn-keyword=筋層浸潤 en-keyword=頚部浸潤 kn-keyword=頚部浸潤 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=663 end-page=668 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Senile diabetes mellitus complicated with celiac arterial obliteration and heaptocellular carinoma : A case report kn-title=腹腔動脈完全閉塞をきたした肝細胞癌合併高齢者糖尿病の興味ある一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a 75-year-old female with diabetes mellitus complicated with celiac arterial obliteration and hepatocellular cercinoma (HCC). She had been treated with diet therapy by her family doctor for essential hypertension and diabetes mellitus and was referred to our hospital because a space occupying lesion (SOL) was detected in the liver by abdominal CT examination. The SOL was confirmed as hepatocellular carcinoma by ultrasonography and magnetic resoance imaging. Celiac angiography revealed complete obliteration of the celiac artery probably due to diabetic macroangiopathy. Sine the deterioration of the liver function was not conspicuous, it was suggested that the development of HCC was affected by diabetes mellitus. en-copyright= kn-copyright= en-aut-name=OkaTakahiko en-aut-sei=Oka en-aut-mei=Takahiko kn-aut-name=岡隆彦 kn-aut-sei=岡 kn-aut-mei=隆彦 aut-affil-num=1 ORCID= en-aut-name=TomodaJun en-aut-sei=Tomoda en-aut-mei=Jun kn-aut-name=友田純 kn-aut-sei=友田 kn-aut-mei=純 aut-affil-num=2 ORCID= en-aut-name=KobashiHaruhiko en-aut-sei=Kobashi en-aut-mei=Haruhiko kn-aut-name=小橋春彦 kn-aut-sei=小橋 kn-aut-mei=春彦 aut-affil-num=3 ORCID= en-aut-name=SakaiNobuyuki en-aut-sei=Sakai en-aut-mei=Nobuyuki kn-aut-name=坂井宣行 kn-aut-sei=坂井 kn-aut-mei=宣行 aut-affil-num=4 ORCID= en-aut-name=SakaguchiKohsaku en-aut-sei=Sakaguchi en-aut-mei=Kohsaku kn-aut-name=坂口孝作 kn-aut-sei=坂口 kn-aut-mei=孝作 aut-affil-num=5 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=6 ORCID= en-aut-name=HigashiToshihiro en-aut-sei=Higashi en-aut-mei=Toshihiro kn-aut-name=東俊宏 kn-aut-sei=東 kn-aut-mei=俊宏 aut-affil-num=7 ORCID= en-aut-name=ItoToshio en-aut-sei=Ito en-aut-mei=Toshio kn-aut-name=伊藤俊雄 kn-aut-sei=伊藤 kn-aut-mei=俊雄 aut-affil-num=8 ORCID= en-aut-name=YamadaGotaro en-aut-sei=Yamada en-aut-mei=Gotaro kn-aut-name=山田剛太郎 kn-aut-sei=山田 kn-aut-mei=剛太郎 aut-affil-num=9 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科学教室 en-keyword=糖尿病 kn-keyword=糖尿病 en-keyword=腹腔動脈閉塞 kn-keyword=腹腔動脈閉塞 en-keyword=肝細胞癌 kn-keyword=肝細胞癌 en-keyword=動脈硬化 kn-keyword=動脈硬化 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=619 end-page=628 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stusies on the pathogenesis in diffuse panbronchiolitis Part 2. Immune responses in diffuse panbronchiolitis kn-title=びまん性汎細気管支炎の病態に関する研究　第2編　びまん性汎細気管支炎患者の免疫能 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various immunological processes are suspected of having some relationship with the onset of diffuse panbronchiolitis (DPB). Therefore, the cellular and humoral immunity of patients with DPB were studied. Sera of patients with DPB showed a high frequency of positive RA factor and high titer of cold agglutinin. Delayed skin tests with phytohemagglutinin (PHA) and purified protein derivative (PPD) in patients with DPB revealed normal responses to PHA as nonspecific mitogen and suppressed responses to PPD as specific antigen, although lymphocyte blastogenesis in vitro showed suppressed responses to PHA. The proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid of DPB patients equaled that of normal controls. Furthermore, the CD4/CD8 ratio of T-cell subsets in BAL fluid of DPB patients were significantly lower than that of normal controls, although the CD4/CD8 ratio in peripheral blood of DPB were significantly higher than that in normal controls. The percentage of B-cells in the peripheral blood of DPB patients was hihger than that in normal controls. These data suggest that the activation of cellular and humoral immune mechanisms could play an important role in the pathogenesis of DPB. en-copyright= kn-copyright= en-aut-name=ShiraishiTakamasa en-aut-sei=Shiraishi en-aut-mei=Takamasa kn-aut-name=白石高昌 kn-aut-sei=白石 kn-aut-mei=高昌 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=びまん性汎細気管支炎 kn-keyword=びまん性汎細気管支炎 en-keyword=気管支肺胞洗浄 kn-keyword=気管支肺胞洗浄 en-keyword=リンパ球サブセット kn-keyword=リンパ球サブセット en-keyword=皮内反応 kn-keyword=皮内反応 en-keyword=リンパ球幼若化反応 kn-keyword=リンパ球幼若化反応 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=11-12 article-no= start-page=987 end-page=997 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinical and radiological study of cervical spinal lesions in patients with progressive rheumatoid arthritis kn-title=慢性関節リウマチにおける頸椎X線病変に関する研究―特に疾患進行度との関連について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=A multivariate analysis of the clinical and radiographic findings of 70 patients with rheumatoid arthritis (RA) was studied. Linear multiple regression analysis was performed on 23 clinical variables. The factors that contributed highly to the progression of vertical atlanto-axial subluxation (VS) were gender, presence of arthritis mutilans, blood hemoglobin level, carpal height ratio (CHR) and the number of joints treated by arthroplasty. This result suggests that the natural progression of VS may well relate to the indicators of the severity of destructive conditions. In contrast, anterior atlanto-axial subluxation (AAS) showed no statistical correlation with any factors. Therefore, the severity of AAS does not appear to be related to the factors that were closely related to VS. A follow-up study of the radiological changes in the cervical spine and hand was performed. There was a high correlation between the severity of VS and the reduction of CHR. As destructive changes in the hands were common and irreversible findings in RA, CHR was the most objective of the factors correlated with VS. Therefore, the measurement of CHR is useful in evaluating the progression of VS. en-copyright= kn-copyright= en-aut-name=NishizawaMasato en-aut-sei=Nishizawa en-aut-mei=Masato kn-aut-name=西澤正人 kn-aut-sei=西澤 kn-aut-mei=正人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部整形外科学教室 en-keyword=慢性関節リウマチ kn-keyword=慢性関節リウマチ en-keyword=頸椎病変 kn-keyword=頸椎病変 en-keyword=X線学的変化 kn-keyword=X線学的変化 en-keyword=多変量解析 kn-keyword=多変量解析 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=145 end-page=162 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinicopatholgical studies on htpersensitivity pneumonitis : Cellular kinetics in bronchoalveolar lavage (BAL) fluid of the patients with hypersensitivity pneumonitis kn-title=過敏性肺臓炎の病態に関する研究ー気管支肺胞洗浄液中の細胞動態を中心にー en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cellular components of bronchoalveolar lavage (BAL) fluids from 26 patients with hypersensitivity pneumonitis were analyzed with regard to the period of antigen exposure before BAL procedure. In the early phase of antigen exposure BAL fluids contained increased neutrophils as well as lymphocytes while a low percentage of neutrophils and a prominent increase of lymphocytes were observed in chronic antigen exposure. Furthermore, the in-creased neutrophils decreased rapidly after cessation of antigen exposure while lymphocytes decreased gradually. In the BAL fluids of patients with summer-type hypersensitivity pneumonitis, CD4+ percentages and CD4/CD8 rations were significantly decreased, but CD8+ percentages significantly increased during antigen exposure compared with that in healthy controls. However, the actual CD4+ cell counts in BAL fluids significantly increased while CD4+ percentage decreased. Thus, CD4+ as well as CD8+ may play important roles in the pathogenesis of hypersensitivity pneumonitis. Soluble IL-2 receptor (sIL-2R) levels in BAL fluids and serum obtained from patients with hypersensitivity pneumonitis, especially serum sIL-2R during the active phase, were signifi-cantly higher than those of normal controls, indicating that the elevated sIL-2R level reflect-ed a highly activated immune response. In relation to pulmonary fuction, the lympocyte percentage showed a significant inverse correlation with % TLC and PaCO2, while neutrophil percentage showed significant correlation with % TLC and inverse correlation with FEV 1.0%. These reaults suggest that neutrophilia in BAL fluids affects bronchobronchiolar disorders during the early phase, and lympocytosis in BAL fluids regulates organic changes of the lung in hypersensitivity pneumonitis. en-copyright= kn-copyright= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=過敏性肺臓炎 kn-keyword=過敏性肺臓炎 en-keyword=気管支肺胞洗浄法 kn-keyword=気管支肺胞洗浄法 en-keyword=Tリンパ球サブセット kn-keyword=Tリンパ球サブセット en-keyword=吸入誘発試験 kn-keyword=吸入誘発試験 en-keyword=肺機能 kn-keyword=肺機能 END start-ver=1.4 cd-journal=joma no-vol=110 cd-vols= no-issue=1-6 article-no= start-page=31 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980625 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=2β-(3-Hydroxypropoxy)1α,25-Dihydroxyvitamin D(3)(ED-71), increases bone mass by stimulating bone formation in hypophosphatemic mice kn-title=活性型ビタミンD(3)誘導体である2β-(3-hydroxypropoxy)-1α,25(OH)(2)D(3)(ED-71)による骨密度増加作用―hypophosphatemic マウスにおける検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To determine the effects of ED-71, a new active vitamin D3 analogue, on bone, we examined the action of ED-71 and 1α,25(OH)(2)D(3), using hypophosphatemic (Hyp) mice, a model for X-linked hypophosphatemic rickets in humans. ED-71 has the unique characteristics of a longer half-life in serum, a higher binding affinity to serum vitamin D binding protein and lower affinity to the vitamin D receptor than 1α,25(OH)(2)D(3). Hyp mice were treated with 10-1200 pmol/kg/day of ED-71, 40-400 pmol/kg/day of 1α,25(OH)(2)D(3), or the vehicle alone, administered daily for 21 days by subcutaneous injection. ED-71 at doses of 100-400 pmol/kg/day, dose-dependently effects in increased bone size and bone mineral density (BMD) without causing hypercalcemia. However 1α,25(OH)(2)D(3) at a dose of 400 pmol/kg/day, demonstrated only slight increases in bone size and BMD with hypercalcemia. These findings suggest that ED-71 may be more beneficial in the treatment of X-linked hypophosphatemic rickets than 1α,25(OH)(2)D(3). en-copyright= kn-copyright= en-aut-name=OchiHideaki en-aut-sei=Ochi en-aut-mei=Hideaki kn-aut-name=越智英明 kn-aut-sei=越智 kn-aut-mei=英明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部小児科学講座 en-keyword=ED-71 kn-keyword=ED-71 en-keyword=Hyp mouse kn-keyword=Hyp mouse en-keyword=BMD kn-keyword=BMD en-keyword=Ca kn-keyword=Ca END start-ver=1.4 cd-journal=joma no-vol=111 cd-vols= no-issue=3-8 article-no= start-page=61 end-page=69 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Aging and exocrine pancreatic function evaluated by endoscopic retrograde aspiration of pure pancreatic juice kn-title=膵外分泌機能の加齢による変化 ―内視鏡的純粋膵液採取法による検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=I syudied the relationship between aging and exocrine pancreatic function by endoscopic retrograde aspiration of pure pancreatic juice (PPJ). Control subjects consisted of 65 out-patients presenting mild vague abdominal aymptoms who fulfilled the following three criteria : 1) good general condition with no known organic diseaes ; 2) no abnormality in the live, bile duct, pancreas. kidney or metabolism ; 3) no alcohol consumption. Nineteen patients with definite pancreatitis were also studied. PPJ was collected form within the pancreatic duct by endoscopic retrograde catheterization of the papilla for 10 minutes after a bolus intravenous injection of secretion (Secrepan, Eisai co., Ltd., 100 U/bpdy). Exocrine pancreatic function was evaluated three parameters as fillows : secretory volume, maximal bicarbonate concentration or bicarbonate output, and enyme (amyase and lipase) output. The ordinary duodenal secretin test was also performed. Exocrine pancreatic function (both duct-cell and acinar-cell function) was significantly reduced in the elderly. The age-associated reduction showed a different pattern between duct-cell and acinar-cell function. The degree of duct-cell dysfunction was significantly higher than that of acinar-cell dysfuntion in the elderly. Influence of aging on maximal bicarbonate concentration was more clearly demonstrated by PPJ aspiration than by the ordinary secretin test. Elderly controls showed as much exocrine dysfuction as patients with chronic pancreatitis, making it difificult to diagnose chronic pancreatitis based on the exocrine function test alone. Therfore, clinical symptoms and findings as well as imaging tests should be considered for the correct diagnosis. en-copyright= kn-copyright= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科教室 en-keyword=加齢 kn-keyword=加齢 en-keyword=膵外分泌機能 kn-keyword=膵外分泌機能 en-keyword=内視鏡的純粋膵液採取法 kn-keyword=内視鏡的純粋膵液採取法 en-keyword=セクレチン試験 kn-keyword=セクレチン試験 en-keyword=慢性膵炎 kn-keyword=慢性膵炎 END start-ver=1.4 cd-journal=joma no-vol=113 cd-vols= no-issue=1 article-no= start-page=1 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010428 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Establishment of an adriamycin-resistant human bladder cancer cell line (T-24/ADM) and analysis of the mechanism of resistance kn-title=Adriamycin 耐性ヒト膀胱癌培養細胞株の樹立と耐性機序に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A human bladder cencer cell line resistant to adriamycin (ADM), T-24/ADM was establishied in vitro by exposing T-24 parent cells to a progressively higher concentration of the drug over an 18 month period. The T-24/ADM was 34.9 times more resistant to ADM than the T-24 parent. The T-24/ADM exhibited cross resistance to ADM derivatives, vinca alkaloid (vindesine, vincristine), etoposide and SN-38, but collateral sensitivity to methotrexate. The biological and biochemical characteristics of T-24/ADM were examined in terms of ADM-resistance. Although a flow cytometric analysis showed that Pglycoprotein is not expressed on the T-24/ADM cells, lower accumalation of the drug caused by decreased uptake and increaced active efflux were observed. The cellular level of glutathione-S-transferase π was 1.8-fold higher than the parent cells and the activity of nuclear extracts of DNA topoisomerase U for T-24/ADM assayed by decatenation of kinetoplast DNA was lower, about one-half that of the T-24 parent. Confocal laser microscopy revealed the difference in intracellular distribution of ADM in T-24/ADM; in particular, the accumlation of the drug in the nucleus decreased. Additionally western blot analysis showed an enhanced expression of multidrug resistance-associated protein (MRP) in the T-24/ADM cells. This resistant cell may be used as an experimantal system to elucidate the mechanisum of ADM resistance and also as a model for developing new chemotherapeutic strategies against multi-drug resistant bladder cancer. en-copyright= kn-copyright= en-aut-name=AkebiNaoki en-aut-sei=Akebi en-aut-mei=Naoki kn-aut-name=野比直樹 kn-aut-sei=野比 kn-aut-mei=直樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部泌尿器科学教室 en-keyword=adriamycin resistance kn-keyword=adriamycin resistance en-keyword=human bladder cancer cell line kn-keyword=human bladder cancer cell line en-keyword=multidrug resistance kn-keyword=multidrug resistance END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=3 article-no= start-page=221 end-page=224 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=IgG4関連自己免疫疾患 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療教育統合開発センター en-keyword=IgG4関連自己免疫疾患 kn-keyword=IgG4関連自己免疫疾患 en-keyword=自己免疫性膵炎 kn-keyword=自己免疫性膵炎 en-keyword=後腹膜線維症 kn-keyword=後腹膜線維症 en-keyword=Mikulicz 病 kn-keyword=Mikulicz 病 en-keyword=IgG4 kn-keyword=IgG4 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=285 end-page=292 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=II Standard treatment for advanced lung cancer kn-title=II 肺癌の内科的治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=1 ORCID= en-aut-name=TakigawaNagio en-aut-sei=Takigawa en-aut-mei=Nagio kn-aut-name=瀧川奈義夫 kn-aut-sei=瀧川 kn-aut-mei=奈義夫 aut-affil-num=2 ORCID= en-aut-name=OzeIsao en-aut-sei=Oze en-aut-mei=Isao kn-aut-name=尾瀬功 kn-aut-sei=尾瀬 kn-aut-mei=功 aut-affil-num=3 ORCID= en-aut-name=YasugiMasayuki en-aut-sei=Yasugi en-aut-mei=Masayuki kn-aut-name=八杉昌幸 kn-aut-sei=八杉 kn-aut-mei=昌幸 aut-affil-num=4 ORCID= en-aut-name=OchiNobuaki en-aut-sei=Ochi en-aut-mei=Nobuaki kn-aut-name=越智宣昭 kn-aut-sei=越智 kn-aut-mei=宣昭 aut-affil-num=5 ORCID= en-aut-name=HaradaDaijiro en-aut-sei=Harada en-aut-mei=Daijiro kn-aut-name=原田大二郎 kn-aut-sei=原田 kn-aut-mei=大二郎 aut-affil-num=6 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 en-keyword=放射線化学療法 kn-keyword=放射線化学療法 en-keyword=分子標的治療 kn-keyword=分子標的治療 en-keyword=血管新生阻害薬 kn-keyword=血管新生阻害薬 en-keyword=受容体チロシンキナーゼ阻害薬 kn-keyword=受容体チロシンキナーゼ阻害薬 END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue= article-no= start-page=59 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Gender and Japan-Korea Differences in Psychological Characteristics through DIPCA and POMS for All Japan Wheelchair Basketball Atheletes kn-title=日本代表車椅子バスケットボール選手の性差及び韓国代表選手との国際比較　−DIPCAとPOMSを用いて− en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although previous studies investigating physical performance and biomechanics in wheelchair-bound athletes were reported, few studies have characterized the psychological state of these athletes. This study investigated differences in psychological characteristics among 37 wheelchair-bound athletes (Japanese males, n=11; Japanese females, n=9; Korean males, n=17). All subjects belonged to their own national teams for disabled wheelchair basketball. All subjects completed both the Diagnostic Inventory of Psychological-Competitive Ability for Athletes (DIPCA) and the Profile Of Mood States (POMS). Statictics analysis of DIPCA showed that the psychological competitive abilities in the Japanese males were significantly better than those in the Korean males in this series. However. the scores on POMS did not show significant differences between the Japanese and Korean males, expect for the score for "anger". Neither DIPCA nor POMS showed any significant differences with regard to gender. Above all, we conclude that the psychological differences between Japanese and Koreans reflected the outcomes of international competitions and these there was no gender difference in psychological characteristics. en-copyright= kn-copyright= en-aut-name=MiuraKoji en-aut-sei=Miura en-aut-mei=Koji kn-aut-name=三浦孝仁 kn-aut-sei=三浦 kn-aut-mei=孝仁 aut-affil-num=1 ORCID= en-aut-name=MatsuiKumiko en-aut-sei=Matsui en-aut-mei=Kumiko kn-aut-name=松井久美子 kn-aut-sei=松井 kn-aut-mei=久美子 aut-affil-num=2 ORCID= en-aut-name=KatayamaKeiko en-aut-sei=Katayama en-aut-mei=Keiko kn-aut-name=片山敬子 kn-aut-sei=片山 kn-aut-mei=敬子 aut-affil-num=3 ORCID= en-aut-name=IshikawaKazuhiro en-aut-sei=Ishikawa en-aut-mei=Kazuhiro kn-aut-name=石川和裕 kn-aut-sei=石川 kn-aut-mei=和裕 aut-affil-num=4 ORCID= en-aut-name=SatoFumihiko en-aut-sei=Sato en-aut-mei=Fumihiko kn-aut-name=佐藤文彦 kn-aut-sei=佐藤 kn-aut-mei=文彦 aut-affil-num=5 ORCID= en-aut-name=OchiEisuke en-aut-sei=Ochi en-aut-mei=Eisuke kn-aut-name=越智英輔 kn-aut-sei=越智 kn-aut-mei=英輔 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=広島大学 affil-num=6 en-affil= kn-affil=日本体育大学 en-keyword=Wheelchir Athletes kn-keyword=Wheelchir Athletes en-keyword=POMS kn-keyword=POMS en-keyword=DIPCA kn-keyword=DIPCA END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=2 article-no= start-page=215 end-page=217 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A human case of Thelazia callipaeda infection in a 3-year old children in Fukuyama City, Hiroshima Prefecture kn-title=福山市で見い出された東洋眼虫の人体寄生例 en-subtitle= kn-subtitle= en-abstract=A case of eye infection of Thelazia callipaeda was observed in a 3-year old children in Fukuyama City, Hiroshima Prefecture in 1995. He had a pain or feeling like a foreign object in his right eye. A total of 2 adults Thelazia callipaeda (male and female) was recovered from theconjunctival sac by an oculist. The symptoms were went out after the removal of the worms. kn-abstract=東洋眼虫の人体寄生例は関東以西で、おもに九州から報告されてきた。中国地方におけるこの寄生虫の人体症例は下田ら(1))が第1例を、Miura et al. (2))が第2例をいずれも岡山県から報告しているだけである。今回福山市で初めて人体症例に遭遇したので報告する。 en-copyright= kn-copyright= en-aut-name=OchiTsuneto en-aut-sei=Ochi en-aut-mei=Tsuneto kn-aut-name=越智常登 kn-aut-sei=越智 kn-aut-mei=常登 aut-affil-num=1 ORCID= en-aut-name=KusauraJunko en-aut-sei=Kusaura en-aut-mei=Junko kn-aut-name=草浦潤子 kn-aut-sei=草浦 kn-aut-mei=潤子 aut-affil-num=2 ORCID= en-aut-name=KobayashiTakako en-aut-sei=Kobayashi en-aut-mei=Takako kn-aut-name=小林孝子 kn-aut-sei=小林 kn-aut-mei=孝子 aut-affil-num=3 ORCID= en-aut-name=SaitoTetsuro en-aut-sei=Saito en-aut-mei=Tetsuro kn-aut-name=斎藤哲郎 kn-aut-sei=斎藤 kn-aut-mei=哲郎 aut-affil-num=4 ORCID= en-aut-name=TonguYasumasa en-aut-sei=Tongu en-aut-mei=Yasumasa kn-aut-name=頓宮廉正 kn-aut-sei=頓宮 kn-aut-mei=廉正 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=越智眼科昭和町医院 affil-num=2 en-affil= kn-affil=福山市医師会総合健診センター affil-num=3 en-affil= kn-affil=福山市医師会捻合総合センター affil-num=4 en-affil= kn-affil=斎藤獣医科病院 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部 en-keyword=東洋眼虫 (Thelazia callipaeda) kn-keyword=東洋眼虫 (Thelazia callipaeda) en-keyword=人体症例 (human case) kn-keyword=人体症例 (human case) en-keyword=福山市 (Fukuyama City) kn-keyword=福山市 (Fukuyama City) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=73 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Re-evaluation of spa-drink therapy for digestive diseases kn-title=消化器疾患における飲泉療法の再評価 en-subtitle= kn-subtitle= en-abstract=With the advent of new instruments for examining the digestive organs, we have attempted to re-evaluate the efficacy and indications of spa-drink therapy for digestive diseases. This report deals with an overview of the results we have obtained so far. Effect of oral intake of thermal water (Misasa thermal water, 38-42℃, 150-200 ml) on gastric mucosal blood flow was evaluated, using an endoscopic organ reflex spectrophotometry together along with an Olympus XQ - 10 forward viewing gastrofiberscope. Single intake of thermal water as well as long-term spa-drink therapy (two times a day between meals for more than two weeks) brought about an improvement of gastric mucosal blood flow. Gastric emptying function was evaluated with an acetaminophen method. Single intake of thermal water brought about disordered gastric emptying (excessively accelerated or suppressed). However, long-term spa-drink therapy brought about an improvement (normalization) of gastric emptying function. Exocrine pancreatic function was evaluated with a synthetic peptide, N-BT-PABA, and also by measuring fecal chymotrypsin actIvIty. Longterm spa-drink therapy brought about an improvement of exocrine pancreatic function. Motility of the gall-bladder was evaluated by abdominal ultra-sonography. Long-term spa-drink therapy gave no effect on the motility of the gallbladder. In conclusion, our recent study indicate that : (1) single oral intake of thermal water as well as longterm spa-drink therapy is effective for gastric diseases related to decreased gastric mucosal blood flow (treatment of intractable peptic ulcer and chronic gastritis, and prevention of recurrence of peptic ulcer) ; (2) long-term spa-drink therapy is effective for dyspepsia syndrome; (3) long-term spa-drink therapy is effective as a supplemental method in the treatment of exocrine pancreatic dysfunction (chronic pancreatitis) ; (4) thermal water should be taken between meals. kn-abstract=従来飲泉などの温泉治療は経験的知識にもとづいて行われる部分が多かったが，今後は科学的検査法を用いて有用性，適応疾患，適応病態，などを決定する必要がある。筆者らは，最近紹介された簡便な消化器検査法を用いて消化器疾患に対する飲泉療法の適応を再吟味しているので，これまでに得られた成績を中心に概説した。すなわち，(1)飲泉は1回でも連日の飲用でも，胃粘膜血流を改善する作用がある。(2)胃排出機能に対しては調整的効果を有する。(3)連日の飲泉は膵外分泌機能を改善する。したがって慢性の胃，膵疾患において粘膜血流障害，胃運動機能異常あるいは膵外分泌機能低下に起因する病気・病態に対しては積極的に飲泉療法を試みるべきである。温泉水の温度は40℃前後，飲泉の量は150〜200ml，タイミングは食間空腹時がよい。 en-copyright= kn-copyright= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=飲泉療法 (Spa-drink therapy) kn-keyword=飲泉療法 (Spa-drink therapy) en-keyword=消化器機能 (Digestive function) kn-keyword=消化器機能 (Digestive function) en-keyword=胃粘膜血流 kn-keyword=胃粘膜血流 en-keyword=胃排出能 kn-keyword=胃排出能 en-keyword=膵外分泌 kn-keyword=膵外分泌 en-keyword=胆嚢機能 kn-keyword=胆嚢機能 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=36 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical study on polypoid lesions of the colon kn-title=大腸ポリープの臨床的検討 en-subtitle= kn-subtitle= en-abstract=This report is concerned with clinical study on 90 patients with polypoid lesions (107 lesions) which we have encountered in Misasa Hospital, Okayama University in the past 4 years. Following results were obtained : (1) Polypoid lesions were detected in 90 (22.4%) and advanced adenocarcinoma (mostly resectable) in 22 (5.5%) of 402 patients who were examined by sigmoidoscopy and barium enema ; (2) Histological examination of the polypoid lesions showed adenoma in 77.2%, hyperplastic polyp in 8.7%, inflammatory polyp in 7.6%, neurinoma in 0.3% and early cancer (adenocarcinoma) in 5.4% ; (3) It was impossible to differentiate benign and malignant polypoid lesions on the basis of endoscopic and X-ray findings alone ; (4) Forty-two percent of the polypoid lesions was detected in the sigmoid colon, 30% in the rectum, 16.8% in the descending colon, 9.3% in the ascending colon, 0.9% in the caecum ; (4) Patients younger than 50 years of age showed only one polypoid lesion in the right hemicolon, whereas elder patients showed as many as 17 polypoid lesions ; (5) Among the 90 patients with polypoid lesions, 40 presented with abdominal pain, 20 with no symptoms (annual health check-up), 17 with irregular bowel habits, and 10 with melena ; (6) Among the 90 patients, occult blood in stool was positive in 75.8% with a lower positive rate in the lesions of the sigmoid and rectum ; (7) Among 5 asymptomatic patients with lesions and with a negative hemoccult test, 3 patients with a polypoid lesion were examined because of the patients' request, 1 patient with a polypoid lesion because of a positive family history, and the remaining 1 patient in a search for the primary lesion of the metastatic liver cancer ; (8) Among patients with a positive hemoccult test, the detection rate of polypoid lesions was 41.9% with use of an immunological method, whereas it was 19.7% with use of a chemical method. In conclusion, (1) detection of colonic polypoid lesions can lead to the detection of early cancer, although only histological examination can confirm the accurate diagnosis ; (2) a hemoccult test in stool with an immunological method is an effective method for screening asymptomatic colonic polypoid lesions, although it must be admitted that negative results may occasionally occur ; (3) macroscopic observation of the stool mass is important before sampling, because lesions of the sigmoid colon or the rectum may show scanty blood only on the limited area of the surface of the stool ; (4) patients elder than 50 years of age should be examined more carefully for the whole colon preferably with an endoscope, because they show a high incidence of small polypoid lesions in the right hemicolon. kn-abstract=1986年4月から1990年2月末までの間に岡山大学医学部附属病院三朝分院で経験した早期大腸癌を含む大腸ポリープ90例（107病変）を対象に，年齢，臨床症状，便潜血反応，病変存在部位について検討を行い，以下の成績を得た。(1)大腸検査総数の22.4％にポリープが発見された。ポリープの77％は腺腫，5％は腺癌（早期癌）であった。(2)便潜血反応はポリープ例の75.9％に陽性であり，右側大腸ポリープでの陽性率は高かったが，S状結腸および直腸ポリープでは70％程度であった。(3)若年者では右側結腸にポリープが発見されることは稀であるが，50才以上では18％程度に認められた。高齢者では右側結腸も内視鏡で検査することが重要である。(4)免疫学的便潜血検査法の導入により大腸ポリープの発見効率が改善するものと考え られた。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=6 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=7 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学附属病院三朝分院放射線科 affil-num=8 en-affil= kn-affil=岡山大学附属病院三朝分院放射線科 en-keyword=大腸ポリープ (Polyp of the colon) kn-keyword=大腸ポリープ (Polyp of the colon) en-keyword=大腸早期癌 (Early cancer of the colon) kn-keyword=大腸早期癌 (Early cancer of the colon) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=79 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diabetic complications in the advanced stage of chronic pancreatitis. kn-title=膵性糖尿病の合併症 en-subtitle= kn-subtitle= en-abstract=Exocrine dysfunction (maldigestion) and endocrine dysfunction (diabetes) are malll clinical features in the advanced stage of chronic pancreatitis. Diabetic complications were previously considered to be infrequent in diabetes secondary to chronic pancreatitis (pancreatic diabetes). However, the recent improvement in life expectancy and closer observation of the clinical course of patients with chronic pancreatitis have revealed that diabetic complications are not infrequent in pancreatic diabetes as compared with primary diabetes mellitus and that diabetes is one of the most important prognostic factors in chronic pancreatitis. We, therefore, reviewed recent articles on the topics before beginning a national survey of diabetic complications in patients with pancreatic diabetes. It has been suggested that : (1) diabetic microangiopathy (retinopathy, nephropathy and peripheral neuropathy) is almost as frequent in secondary diabetes as in primary diabetes, although the severity is less in secodary diabetes : (2) peripheral neuropathy is frequent in alcoholic chronic pancreatitis : (3)macroangiopathy (myocardial infarction, cerebral thrombosis, atherosclerosis) is less frequent in pancreatic diabetes. We also discussed various factors which may precipitate the diabetic complications. kn-abstract=慢性膵炎が進行すると膵内外分泌不全に対する治療が主体となる。かつては膵疾患に由来する糖尿病（膵性糖尿病）においては糖尿病性合併症の発症が少ないとされていたが，慢性膵炎の長期経過観察例の増加とともにその頻度が一次性糖尿病にくらべて必ずしも低くないことが指摘されるようになった。そこで今回，厚生省難治性膵疾患調査研究班「慢性膵炎の新しい治療法の開発」小委員会の研究活動の一環として膵性糖尿病の治療法を再検討することになったのを機会に，その手始めに野性糖尿病の合併症に関する従来の報告を整理した。その結果，一次性糖尿病の場合にくらべて，細小血管症（網膜症，腎症，神経障害）はほぼ同程度であるが軽症例が多いこと，大血管症（心筋梗塞，脳硬塞，動脈硬化症）は少ないことが示唆された。そのほか，膵性糖尿病の合併症の発症に関与すると考えられる諸因子についても概説した。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=膵性糖尿病 (Pancreatic diabetes) kn-keyword=膵性糖尿病 (Pancreatic diabetes) en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=合併症 (Complications) kn-keyword=合併症 (Complications) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=123 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of stepping measurement device for evaluation of and training in walking kn-title=群性膵炎の発症原因の検索中に発見された小膵癌の検討 en-subtitle= kn-subtitle= en-abstract=Although gait training equipment such as the bicycle ergometer and treadmill exists for patients whose walking ability is high, there is no appropriate gait training mehtod or training instrument for patients whose walking ability has become impaired, who often use a cane or walker, etc. in the course of daily life. In the case of gait training for persons whose walking ability involves impaired locomotion, there is always the danger of a fall. Consequently, a caregiver is required, and the effect of the training is cut by half because the patient's anxiety about falling is exacerbated. Slow stepping affords strengthening and balance training of the leg muscles for patients whose walking ability has become low, and walking ability is improved. However,whether such training appropriately carries out stepping and the degree of the effect of such training has not been evaluated. Therefore, we have developed a stepping measturement device that monitors stepping for evaluation and training of walking ability. This system consists of two mat switches for stepping, a measuring circuit for stepping detection, and a book-sized personal computer with a PC card-type AD converter. This system can detect a left or right single stance phase and a double stance phase relative to the ON, OFF condition of the mat switch. After measurement, the following items are analyzed and displayed : ・number of steps, ・average time of double stance phase, ・the average time of single stance phase, and so on. Finally, we measured the stepping of subjects whose walking ability is low, and showed the relationship between daily walking conditions and stepping conditions. The effectiveness of this system was considered in light of the results. kn-abstract=急性膵炎の回復後その発症原因の検索において発見された小膵癌の3例を報告し，膵炎の発症原因の一つとして膵癌を常に念頭におく必要があることを強調した。またスクリーニング検査および精査において小膵癌を診断する手順について考察を加えた。症例1は初回発作の回復後に，症例2および症例3は再発発作の回復後に急性膵炎の発症原因の検索を目的に紹介された。いずれの症例においても血清腫瘍マーカーは正常植を示し，腹部USおよびCTは腫瘍から尾側の膵管の拡張を示したが腫瘍そのものは描出はできなかった。症例1ではERCP像から膵体部癌を強く疑い，症例2と症例3ではERCP像と細胞診陽性所見から膵頭部癌と確診し，手術を行った。腫瘍の最大径は症例1では0.9cm，症例2では1.5cm，症例3では2.0cmであり，いずれも転移を認めず根治切除可能であった。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=3 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=4 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=TsuboiKeiichi en-aut-sei=Tsuboi en-aut-mei=Keiichi kn-aut-name=壷井圭一 kn-aut-sei=壷井 kn-aut-mei=圭一 aut-affil-num=7 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=小膵癌 (Small pancreatic cancer) kn-keyword=小膵癌 (Small pancreatic cancer) en-keyword=膵癌の早期発見 (Early diagnosis of pancreatic cancer) kn-keyword=膵癌の早期発見 (Early diagnosis of pancreatic cancer) en-keyword=急性膵炎 (Acute pancreatitis) kn-keyword=急性膵炎 (Acute pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=5 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Trial of a mass screening survery for detecting early pancreatic cancer kn-title=膵集検にかんする研究 en-subtitle= kn-subtitle= en-abstract=To find an effective mass screening method for detecting early pancreatic cancer among asymptomatic populations and patients with vague abdominal symptoms, a prospective study was attempted on 1748 patients who came to Medical Clinic of Misasa Branch Hospital, Okayama University Medical School mostly for a routine annual chek-up from June 1, 1986 through June 30, 1990. These patients underwent first-step screeing tests including serum amylase, elastase I and routine abdominal ultrasonography (US). Consequently 155 patients (8.9% of the total 1748 patients) showed abnormal findings and underwent secondstep tests including US, ERCP and computed tomography. Final diagnosis was early pancreatic cancer in one patient and advanced pancreatic cancer in four. Three of the 5 patients with pancreatic cancer were in their sixties. Detection rate of pancreatic cancer (0.29%) in this series was satisfactory as compared with the results of previous reports with US alone. The rate of second-step examination increased with age. Six hundred and forty-one patients (36.7% of the 1748 patients) underwent follow-up examinations more than one year after the previous test. No pancreatic cancer was detected in the 641 patients. The rate of follow-up examination in patients in their sixties was significantly lower than in those in their forties or fifties. It is important to improve the follow-up rate in patients in their sixties, because they are at a high risk for pancreatic cancer as suggested by the present study. kn-abstract=早期膵癌を発見するためのスクリーニング法を確立するため，1986年6月1日から1990年6月30日までの期間のprospective studyを行った。対象は，人間ドックを目的として来院した患者を主とする三朝分院の外来患者1,748名である。一次スクリーニング検査として，血清アミラーゼ，エラスターゼI，腹部超音波検査（US）を施行し155名の要精検者が得られ，要精検率は8.9％であった。155名の要精検者に，二次検査として，USの再精査，ERCP，腹部CTを施行した。その結果，早期膵癌患者1名，進行膵癌患者4名を発見し，膵癌発見率は0．29％と良好な成績であった。加えて，一次スクリーニングの検査項目を限定することによりcost−benifitを改善することができた。発見された膵癌患者の3名は60歳代であった。また，年代別要精検率は加齢とともに上昇した。1年以後にfollow-up検査を受けた患者の数は641名でfoilow−up率は36．7％であり，そのなかから膵癌は発見されなかった。60歳代のfollow−up率は40歳以上60歳未満のそれにくらべて有意の低値をとった。早期膵癌の見逃しを少なくするためには，今後，60歳代を中心とする患者のfollow−up率をさらに高めることが必要である。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 en-keyword=膵集検 (Mass screening for pancreatic cancer) kn-keyword=膵集検 (Mass screening for pancreatic cancer) en-keyword=膵癌の早期診断 (Early diagnosis of pancreatic cancer) kn-keyword=膵癌の早期診断 (Early diagnosis of pancreatic cancer) en-keyword=早期膵癌 (Small pancreatic cancer) kn-keyword=早期膵癌 (Small pancreatic cancer) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=11 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A dietary survey in patients with chronic pancreatitis kn-title=慢性膵炎患者の食事調査 en-subtitle= kn-subtitle= en-abstract=Importance of diet therapy has been emphasized in chronic pancreatitis. However, concrete measures and programs of the diet therapy have remained to be studied. Therefore, Intractable Pancreatic Disease Study Group recently carried out a nation-wide questionnaire survey on the diets in patients with chronic pancreatitis under the auspIces of the Ministry of Health and Welfare. Attendant physicians were requested to report the nutritional states of their patients and the kinds and amounts of foods taken by their patients on three consecutive days. The nutritional state was evaluated by a body weight index calculated by the following formula:Body Weight Index (%) = Present Body Weight / Ideal Body Weight X 100. Daily nutritional intake (calorie, protein, fat, carbohydrate, and others) was calculated by dieticians according to the Food Exchange Table published by the Japanese Association of Diabetes. The present study constitutes a part of the group study. Patients consisted of 44 men and 12 women who fulfilled the diagnostic criteria proposed by the Japanese Society of Gastroenterology;20 men and 3 women had secondary diabetes mellitus. Following results and conclusions were obtained. (1) Average daily calorie intake of the patients was 1,759kcal as compared with 2,057kcal in the general population in Japan. Sixteen patients (28.6%) showed daily calorie intake less than 1,400 kcal and consequently poor nutritional states (6 patients with body weight indices less than 80% and 10 with 80-90%). It is important, therefore, to try to improve the daily calorie intake by increasing the frequency of diets in these patients. (2) Average daily intake of protein was 72.1 g (animal protein 38.1 g), only slightly less than 79.2 g (animal protein 41.7 g) in the general population. However, as many as 16 patients (28.6%) showed daily protein intake of less than 60 g and poor nutritional states as described above. It is important, therfore, to encourage patients to maintain the daily protein intake of more than 60 g by increasing the frequency of diets with oral administration of digestive enzymes. (3) Average daily intake of fat was 39.9 g (animal fat 23.8 g), approximately 20 g less than 58.3 g (animal fat 28.0 g) in the general population. As many as 17 patients (30.4%) showed daily fat intake of less than 30 g , and 16 of the 17 patients showed poor nutritional states as described above. It is important, therefore, to encourage patients to maintain the daily fat intake of more than 30 g (especially by increasing the amounts of vegetable oil) by increasing the frequency of diets with oral administration of digestive enzymes. (4) Average daily intake of carbohydrate was 278 g, almost equal to 289 g in the general population. However, many patients took as much as 48 g of carbohydrate in the from of cakes, plain sugar and alcohol beverages. Seventeen men (39%) and one woman (8%) had continued drinking alcohol beverages even after the diagnosis was made. It is important, therefore, to encourage patients to improve the quality of carbohydrate intake, although it is admittedly difficult to realize the ideal. (5) Intake of vitamins and minerals (especially calcium) also tended to be insufficient. Green vegetables were especially insufficient. (6) In conclusion, it is utmost important in chronic pancreatitis to perform periodical evaluation of nutritional intake and feed back the information to the treatment through a close patient-dietician-doctor relationship. kn-abstract=食事療法は慢性膵炎治療の基本として重要であるが，その具体的な内容についてはあまり明確にされていない。今回，筆者らは慢性膵炎例の食事に関する全国調査の一部を担当したので，その成績を報告し，問題点と対策について考察した。対象は慢性膵炎間欠期の患者56名（男44名，女12名）である。(1)エネルギー摂取量では1日1,400kcal以下が16名（29％）にみられ，肥満度80〜90％が7名および80％以下が9名という栄養状態と考え合わせて，食事の回数を増やしてでも摂取エネルギーの改善をはかる必要がある。(2)蛋白質および脂質摂取量についても同様な成績であり，消化酵素剤を投与しながら量的，質的な改善をはかる必要がある。(3)糖質については質的改善をはかる必要がある。(4)ビタミンとミネラルも不足傾向にあった。野菜の摂取不足が顕著であった。(5)診断確定後も禁酒できない患者が男17名(39％)，女1名(8％)にみられ，その指導が重要な課題である。 en-copyright= kn-copyright= en-aut-name=HayashimotoKanae en-aut-sei=Hayashimoto en-aut-mei=Kanae kn-aut-name=林下加奈枝 kn-aut-sei=林下 kn-aut-mei=加奈枝 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=TakumaMasae en-aut-sei=Takuma en-aut-mei=Masae kn-aut-name=田熊正栄 kn-aut-sei=田熊 kn-aut-mei=正栄 aut-affil-num=5 ORCID= en-aut-name=MasuiEtsuko en-aut-sei=Masui en-aut-mei=Etsuko kn-aut-name=増井悦子 kn-aut-sei=増井 kn-aut-mei=悦子 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=8 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=9 ORCID= en-aut-name=IzushiMichihiro en-aut-sei=Izushi en-aut-mei=Michihiro kn-aut-name=出石通博 kn-aut-sei=出石 kn-aut-mei=通博 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=9 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=食事療法 (Diet therapy in chronic pancreatitis) kn-keyword=食事療法 (Diet therapy in chronic pancreatitis) en-keyword=栄養状態 (Nutrition in chronic pancreatitis) kn-keyword=栄養状態 (Nutrition in chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ソロ珪酸塩型層状結晶の構造歪に関する構造化学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OchiYasuo en-aut-sei=Ochi en-aut-mei=Yasuo kn-aut-name=越智康雄 kn-aut-sei=越智 kn-aut-mei=康雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=134 cd-vols= no-issue= article-no= start-page=85 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nutritional Status and Competitive Ability in Wheelechair Basketball Players kn-title=車椅子バスケットボール選手に対するアンケート調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract=本研究では、障害者スポーツの中でも最も人気が高く、競技人口の多い競技のうちの１つである車椅子バスケットボール選手を対象にアンケート調査を実施し、競技力向上の手がかりと食生活に関する調査を行い、障害者スポーツ選手のサポート・食生活のあり方について検討することを目的とした。その結果、1)車椅子バスケットボール実施者、競技水準が上がるにつれて年齢は下がっている傾向がみられた、2)車椅子バスケットボール実施理由を「競技志向」、「健康志向」、「きっかけづくり」と3因子に分類したとき「競技志向」と競技水準には有意な相関がみられた、3)「栄養・食生活に関するサポート」と競技水準とについて有意な相関がみられ、競技水準の高いものが栄養・食生活に関する意識が高い傾向がみられた。 en-copyright= kn-copyright= en-aut-name=MiuraKoji en-aut-sei=Miura en-aut-mei=Koji kn-aut-name=三浦孝仁 kn-aut-sei=三浦 kn-aut-mei=孝仁 aut-affil-num=1 ORCID= en-aut-name=MatsuiKumiko en-aut-sei=Matsui en-aut-mei=Kumiko kn-aut-name=松井久美子 kn-aut-sei=松井 kn-aut-mei=久美子 aut-affil-num=2 ORCID= en-aut-name=KatayamaKeiko en-aut-sei=Katayama en-aut-mei=Keiko kn-aut-name=片山敬子 kn-aut-sei=片山 kn-aut-mei=敬子 aut-affil-num=3 ORCID= en-aut-name=OchiEisuke en-aut-sei=Ochi en-aut-mei=Eisuke kn-aut-name=越智英輔 kn-aut-sei=越智 kn-aut-mei=英輔 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=車椅子バスケットボール kn-keyword=車椅子バスケットボール en-keyword=アンケート kn-keyword=アンケート en-keyword=食生活 kn-keyword=食生活 END start-ver=1.4 cd-journal=joma no-vol=131 cd-vols= no-issue= article-no= start-page=51 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=足関節におけるキネシオテープ貼付が身体の重心動揺安定性に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=本研究では、足関節におけるキネシオテープが身体の重心動揺安定性に及ぼす影響について検討するため、重心動揺計及びバランスボードによる評価を行った。その結果、身体の重心動揺安定性に関しては、キネシオテープ貼付が閉眼時のバランス能力を改善させることが示唆された。また、キネシオテープ貼付はバランスボード上での総接地時間を低下させ、その傾向は、前後方向の重心動揺回数においてより顕著であった。以上の結果より、足関節におけるキネシオテープは身体の重心動揺安定性を改善させることが明らかになった。 en-copyright= kn-copyright= en-aut-name=MiuraKoji en-aut-sei=Miura en-aut-mei=Koji kn-aut-name=三浦孝仁 kn-aut-sei=三浦 kn-aut-mei=孝仁 aut-affil-num=1 ORCID= en-aut-name=YamaguchiMakoto en-aut-sei=Yamaguchi en-aut-mei=Makoto kn-aut-name=山口誠 kn-aut-sei=山口 kn-aut-mei=誠 aut-affil-num=2 ORCID= en-aut-name=OchiEisuke en-aut-sei=Ochi en-aut-mei=Eisuke kn-aut-name=越智英輔 kn-aut-sei=越智 kn-aut-mei=英輔 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=キネシオテープ kn-keyword=キネシオテープ en-keyword=足関節 kn-keyword=足関節 en-keyword=重心動揺安定性 kn-keyword=重心動揺安定性 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=宇宙線空気シャワー中の大広域にわたる相関の研究 kn-title=Study on large-scale correlations in cosmic ray air showers en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智信彰 kn-aut-sei=越智 kn-aut-mei=信彰 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=数値解析によるゴム複合体の変形に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智衛 kn-aut-sei=越智 kn-aut-mei=衛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肘関節内側側副靱帯と腕尺関節軸の解剖学的関係について kn-title=Anatomic relation between the medial collateral ligament of the elbow and the humero-ulnar joint axis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智信夫 kn-aut-sei=越智 kn-aut-mei=信夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cis-diamminedichloroplatinum 耐性ヒト膀胱癌培養細胞株の樹立とその特性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智淳三 kn-aut-sei=越智 kn-aut-mei=淳三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=膵管内セクレチン試験は膵外分泌機能の評価に十二指腸セクレチン試験と同等の有用性を有する kn-title=Intraductal secretin test is as useful as duodenal secretin test in assessing exocrine pancreatic function en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ED-71 による骨密度増加作用 Hypマウスにおける検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智英明 kn-aut-sei=越智 kn-aut-mei=英明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END