start-ver=1.4
cd-journal=joma
no-vol=194
cd-vols=
no-issue=
article-no=
start-page=50
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2026
dt-pub=202601
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Increasing visual uncertainty modulates multisensory decision-making
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The brain integrates and transforms information from multiple senses to make optimal decisions, a process that is critical for navigating complex environments with perceptual uncertainty. Despite a growing consensus that individuals adapt flexibly to uncertain sensory input, whether increasing visual uncertainty influences the decision process itself or other, non-decision sensory processes during multisensory decision-making are unclear. Here, an audiovisual categorization task was used to examine the responses of human participants (N = 30) to visual and audiovisual stimuli under low-, medium-, and high-uncertainty conditions. Modeling the behavioral data using a drift?diffusion model indicated that increased visual uncertainty in the audiovisual context decreased the evidence accumulation rate but had no effect on non-decision processes. Electrophysiological recordings confirmed and expanded upon these results: increased visual uncertainty in the audiovisual context reduced the amplitude during the late decision-making stage (300?380 msec) but had no effect on the amplitude during the early sensory encoding stage (140?220 msec). More importantly, electroencephalography analyses revealed that audiovisual integration in the early sensory encoding stage occurred robustly across all visual uncertainty conditions, whereas audiovisual integration in the late stage occurred only under medium and high visual uncertainty conditions. This study demonstrated that increased visual uncertainty modulates the decision process itself rather than early sensory encoding during multisensory decision-making. Moreover, multisensory integration strategies dynamically adapt to increasing visual uncertainty by engaging different mechanisms to maintain effective decision-making.
en-copyright=
kn-copyright=

en-aut-name=YangXiangfu
en-aut-sei=Yang
en-aut-mei=Xiangfu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YangWeiping
en-aut-sei=Yang
en-aut-mei=Weiping
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YuYinghua
en-aut-sei=Yu
en-aut-mei=Yinghua
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=EjimaYoshimichi
en-aut-sei=Ejima
en-aut-mei=Yoshimichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YangJiajia
en-aut-sei=Yang
en-aut-mei=Jiajia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Psychology, Faculty of Education, Hubei University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=Multisensory decision-making
kn-keyword=Multisensory decision-making
en-keyword=Visual uncertainty
kn-keyword=Visual uncertainty
en-keyword=Audiovisual integration
kn-keyword=Audiovisual integration
en-keyword=Event-related potential
kn-keyword=Event-related potential
en-keyword=Drift?diffusion model
kn-keyword=Drift?diffusion model
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=LRP4とAgrinは軟骨変性によって調節されヒト関節軟骨細胞におけるβ-カテニンシグナル伝達に関与する
kn-title=LRP4 and Agrin Are Modulated by Cartilage Degeneration and Involved in β-Catenin Signaling in Human Articular Chondrocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NANIWAShuichi
en-aut-sei=NANIWA
en-aut-mei=Shuichi
kn-aut-name=浪花崇一
kn-aut-sei=浪花
kn-aut-mei=崇一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=虚血性脳卒中モデルラットにおけるヒト改変骨髄由来間質細胞（SB623）の脳内移植と随意運動および強制運動の治療効果
kn-title=Therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) with voluntary and forced exercise in a rat model of ischemic stroke
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NAGASETakayuki
en-aut-sei=NAGASE
en-aut-mei=Takayuki
kn-aut-name=永瀬喬之
kn-aut-sei=永瀬
kn-aut-mei=喬之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=9
article-no=
start-page=1135
end-page=1151
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC?CXCL1?CXCR2 axis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Heart failure (HF) is a growing global health issue. While most studies focus on cardiomyocytes, here we highlight the role of cardiac fibroblasts (CFs) in HF. Single-cell RNA sequencing of mouse hearts under pressure overload identified six CF subclusters, with one specific to the HF stage. This HF-specific CF population highly expresses the transcription factor Myc. Deleting Myc in CFs improves cardiac function without reducing fibrosis. MYC directly regulates the expression of the chemokine CXCL1, which is elevated in HF-specific CFs and downregulated in Myc-deficient CFs. The CXCL1 receptor, CXCR2, is expressed in cardiomyocytes, and blocking the CXCL1?CXCR2 axis mitigates HF. CXCL1 impairs contractility in neonatal rat and human iPSC-derived cardiomyocytes. Human CFs from failing hearts also express MYC and CXCL1, unlike those from controls. These findings reveal that HF-specific CFs contribute to HF via the MYC?CXCL1?CXCR2 pathway, offering a promising therapeutic target beyond cardiomyocytes.
en-copyright=
kn-copyright=

en-aut-name=KomuroJin
en-aut-sei=Komuro
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HashimotoHisayuki
en-aut-sei=Hashimoto
en-aut-mei=Hisayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KatsukiToshiomi
en-aut-sei=Katsuki
en-aut-mei=Toshiomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KusumotoDai
en-aut-sei=Kusumoto
en-aut-mei=Dai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KatohManami
en-aut-sei=Katoh
en-aut-mei=Manami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KoToshiyuki
en-aut-sei=Ko
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ItoMasamichi
en-aut-sei=Ito
en-aut-mei=Masamichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KatagiriMikako
en-aut-sei=Katagiri
en-aut-mei=Mikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KubotaMasayuki
en-aut-sei=Kubota
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YamadaShintaro
en-aut-sei=Yamada
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NakamuraTakahiro
en-aut-sei=Nakamura
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=AkibaYohei
en-aut-sei=Akiba
en-aut-mei=Yohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KoukaThukaa
en-aut-sei=Kouka
en-aut-mei=Thukaa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KomuroKaoruko
en-aut-sei=Komuro
en-aut-mei=Kaoruko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KimuraMai
en-aut-sei=Kimura
en-aut-mei=Mai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=ItoShogo
en-aut-sei=Ito
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=NomuraSeitaro
en-aut-sei=Nomura
en-aut-mei=Seitaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=KomuroIssei
en-aut-sei=Komuro
en-aut-mei=Issei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=FukudaKeiichi
en-aut-sei=Fukuda
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=YuasaShinsuke
en-aut-sei=Yuasa
en-aut-mei=Shinsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=IedaMasaki
en-aut-sei=Ieda
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

affil-num=1
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Frontier Cardiovascular Science, Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Frontier Cardiovascular Science, Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=8
en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=9
en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=10
en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=11
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=12
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=13
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=14
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=15
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=16
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=17
en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=18
en-affil=Department of Frontier Cardiovascular Science, Graduate School of Medicine
kn-affil=

affil-num=19
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=

affil-num=20
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=21
en-affil=Department of Cardiology, Keio University School of Medicine
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=18
cd-vols=
no-issue=8
article-no=
start-page=e70325
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202508
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cardiotoxicity Assessment of EGFR Tyrosine Kinase Inhibitors Using Human iPS Cell‐Derived Cardiomyocytes and FDA Adverse Events Reporting System
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Recent advances in the development of anti-cancer drugs have contributed to prolonged survival of cancer patients. In contrast, drug-induced cardiotoxicity, particularly cardiac contractile dysfunction, is of growing concern in cancer treatment. Therefore, it is important to understand the risks of anti-cancer drug-induced cardiac contractile dysfunction in drug development. We have previously developed image-based motion analysis using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to assess the effect of drugs on contractility. However, the utility and predictive potential of image-based motion analysis using hiPSC-CMs for anti-cancer drug-induced cardiac contractile dysfunction have not been well understood. Here we focused on epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) and investigated the correlation between the hiPSC-CMs data and clinical signals of adverse events related to cardiac contractile dysfunction. We examined the effects of the four EGFR-TKIs, osimertinib, gefitinib, afatinib, and erlotinib, on the contractility of hiPSC-CMs using image-based motion analysis. We found that osimertinib decreased contraction velocity and deformation distance in a dose- and time-dependent manner, whereas gefitinib, afatinib, and erlotinib had little effect on these parameters. Next, we examined the real-world data of the EGFR-TKIs using FDA Adverse Event Reporting System (FAERS; JAPIC AERS). Only osimertinib showed significant clinical signals of adverse events related to cardiac contractile dysfunction. These data suggest that hiPSC-CM data correlate with clinical signals in FAERS analysis for four EGFR-TKIs. Thus, image-based motion analysis using hiPSC-CMs can be a useful platform for predicting the risk of anti-cancer drug-induced cardiac contractile dysfunction in patients.
en-copyright=
kn-copyright=

en-aut-name=YanagidaShota
en-aut-sei=Yanagida
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawagishiHiroyuki
en-aut-sei=Kawagishi
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SaitoMitsuo
en-aut-sei=Saito
en-aut-mei=Mitsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HamanoHirofumi
en-aut-sei=Hamano
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ZamamiYoshito
en-aut-sei=Zamami
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KandaYasunari
en-aut-sei=Kanda
en-aut-mei=Yasunari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Division of Pharmacology, National Institute of Health Sciences (NIHS)
kn-affil=

affil-num=2
en-affil=Division of Pharmacology, National Institute of Health Sciences (NIHS)
kn-affil=

affil-num=3
en-affil=Japan Pharmaceutical Information Center (JAPIC)
kn-affil=

affil-num=4
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Division of Pharmacology, National Institute of Health Sciences (NIHS)
kn-affil=
en-keyword=cardiomyocytes
kn-keyword=cardiomyocytes
en-keyword=cardiotoxicity
kn-keyword=cardiotoxicity
en-keyword=contractility
kn-keyword=contractility
en-keyword=EGFR-tyrosine kinase inhibitor
kn-keyword=EGFR-tyrosine kinase inhibitor
en-keyword=FAERS
kn-keyword=FAERS
en-keyword=human iPS cell
kn-keyword=human iPS cell
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=7661
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240916
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Neurotransmitter recognition by human vesicular monoamine transporter 2
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Human vesicular monoamine transporter 2 (VMAT2), a member of the SLC18 family, plays a crucial role in regulating neurotransmitters in the brain by facilitating their uptake and storage within vesicles, preparing them for exocytotic release. Because of its central role in neurotransmitter signalling and neuroprotection, VMAT2 is a target for neurodegenerative diseases and movement disorders, with its inhibitor being used as therapeutics. Despite the importance of VMAT2 in pharmacophysiology, the molecular basis of VMAT2-mediated neurotransmitter transport and its inhibition remains unclear. Here we show the cryo-electron microscopy structure of VMAT2 in the substrate-free state, in complex with the neurotransmitter dopamine, and in complex with the inhibitor tetrabenazine. In addition to these structural determinations, monoamine uptake assays, mutational studies, and pKa value predictions were performed to characterize the dynamic changes in VMAT2 structure. These results provide a structural basis for understanding VMAT2-mediated vesicular transport of neurotransmitters and a platform for modulation of current inhibitor design.
en-copyright=
kn-copyright=

en-aut-name=ImDohyun
en-aut-sei=Im
en-aut-mei=Dohyun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=JormakkaMika
en-aut-sei=Jormakka
en-aut-mei=Mika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=JugeNarinobu
en-aut-sei=Juge
en-aut-mei=Narinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KishikawaJun-ichi
en-aut-sei=Kishikawa
en-aut-mei=Jun-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KatoTakayuki
en-aut-sei=Kato
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SugitaYukihiko
en-aut-sei=Sugita
en-aut-mei=Yukihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NodaTakeshi
en-aut-sei=Noda
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=UemuraTomoko
en-aut-sei=Uemura
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ShiimuraYuki
en-aut-sei=Shiimura
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MiyajiTakaaki
en-aut-sei=Miyaji
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AsadaHidetsugu
en-aut-sei=Asada
en-aut-mei=Hidetsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=IwataSo
en-aut-sei=Iwata
en-aut-mei=So
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Graduate School of Medicine, Kyoto University
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Graduate School of Medicine, Kyoto University
kn-affil=

affil-num=3
en-affil=Department of Genomics and Proteomics, Advanced Science Research Center, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Applied Biology, Kyoto Institute of Technology
kn-affil=

affil-num=5
en-affil=Institute for Protein Research, Osaka University
kn-affil=

affil-num=6
en-affil=Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University
kn-affil=

affil-num=7
en-affil=Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Graduate School of Medicine, Kyoto University
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Graduate School of Medicine, Kyoto University
kn-affil=

affil-num=10
en-affil=Department of Genomics and Proteomics, Advanced Science Research Center, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Cell Biology, Graduate School of Medicine, Kyoto University
kn-affil=

affil-num=12
en-affil=Department of Cell Biology, Graduate School of Medicine, Kyoto University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=15
article-no=
start-page=e71098
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202508
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Real‐World Data of Comprehensive Cancer Genomic Profiling Tests Performed in the Routine Clinical Setting in Sarcoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Introduction: Next-generation sequencing-based comprehensive cancer genomic profiling (CGP) tests are beneficial for refining diagnosis and personalized treatment of various cancers. However, the clinical impact of CGP, as covered by public health insurance in the management of sarcomas, remains unknown. Especially, the data on the utility of the newly emerging dual DNA?RNA panel compared to the conventional DNA-only panel in clinical settings is lacking. Therefore, we evaluated the utility of CGP in routine clinical practice for sarcoma treatment.<br>
Patients and Methods: In this study, three types of DNA panel and one DNA?RNA panel, reimbursed by Japanese public health insurance, were utilized. We detected oncogenic and druggable gene mutations and genotype-matched therapies.<br>
Results: One hundred and thirty-six patients were included in this study. Based on the detection of highly histology-specific translocations in the sequencing results, 2.2% of patients were re-classified. In patients with translocation-related sarcomas, a DNA?RNA panel identified more histology-specific fusion genes than DNA panels (p?=?0.0035). Specifically, 86.8% and 39.0% of patients had oncogenic and druggable genomic alterations, respectively. Of these, 9.6% underwent genotype-matched therapy, with a 36.3% response rate and an 81.8% disease control rate. Patients who were administered genomically matched therapy had better overall survival (OS) than those who did not in patients with metastatic or advanced sarcoma with no prior chemotherapy (3-year OS: 83.3% vs. 48.0%, p?=?0.42). Patients with TP53 and RB1 mutations had worse OS than those without. Germline findings were detected in 11.0% of the patients, one of whom had a truly germline origin.<br>
Conclusions: This study suggests that publicly reimbursed CGP tests, particularly the dual DNA?RNA panel, could be beneficial for refining diagnostic precision in selected sarcoma subtypes, treatment decisions, detecting the germline findings, and prognosis prediction in routine clinical settings for sarcoma. The implementation of genotype-matched therapies showed favorable clinical outcomes and improved the prognosis.
en-copyright=
kn-copyright=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=EnnishiDaisuke
en-aut-sei=Ennishi
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OsoneTatsunori
en-aut-sei=Osone
en-aut-mei=Tatsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NinomiyaKiichiro
en-aut-sei=Ninomiya
en-aut-mei=Kiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TomidaShuta
en-aut-sei=Tomida
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ItanoTakuto
en-aut-sei=Itano
en-aut-mei=Takuto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KunisadaToshiyuki
en-aut-sei=Kunisada
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IdaNaoyuki
en-aut-sei=Ida
en-aut-mei=Naoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YamamotoHideki
en-aut-sei=Yamamoto
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=FutagawaMashu
en-aut-sei=Futagawa
en-aut-mei=Mashu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=ShimoiTatsunori
en-aut-sei=Shimoi
en-aut-mei=Tatsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=YanaiHiroyuki
en-aut-sei=Yanai
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=HirasawaAkira
en-aut-sei=Hirasawa
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=TabataMasahiro
en-aut-sei=Tabata
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Medical Oncology, National Cancer Center Hospital
kn-affil=

affil-num=13
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=15
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=16
en-affil=Center for Clinical Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=17
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=comprehensive genomic profiling
kn-keyword=comprehensive genomic profiling
en-keyword=genotype-matched therapy
kn-keyword=genotype-matched therapy
en-keyword=multiplex gene panel test
kn-keyword=multiplex gene panel test
en-keyword=sarcoma
kn-keyword=sarcoma
END

start-ver=1.4
cd-journal=joma
no-vol=638
cd-vols=
no-issue=8049
article-no=
start-page=225
end-page=236
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250122
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Immune evasion through mitochondrial transfer in the tumour microenvironment
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cancer cells in the tumour microenvironment use various mechanisms to evade the immune system, particularly T?cell attack1. For example, metabolic reprogramming in the tumour microenvironment and mitochondrial dysfunction in tumour-infiltrating lymphocytes (TILs) impair antitumour immune responses2,3,4. However, detailed mechanisms of such processes remain unclear. Here we analyse clinical specimens and identify mitochondrial DNA (mtDNA) mutations in TILs that are shared with cancer cells. Moreover, mitochondria with mtDNA mutations from cancer cells are able to transfer to TILs. Typically, mitochondria in TILs readily undergo mitophagy through reactive oxygen species. However, mitochondria transferred from cancer cells do not undergo mitophagy, which we find is due to mitophagy-inhibitory molecules. These molecules attach to mitochondria and together are transferred to TILs, which results in homoplasmic replacement. T?cells that acquire mtDNA mutations from cancer cells exhibit metabolic abnormalities and senescence, with defects in effector functions and memory formation. This in turn leads to impaired antitumour immunity both in vitro and in vivo. Accordingly, the presence of an mtDNA mutation in tumour tissue is a poor prognostic factor for immune checkpoint inhibitors in patients with melanoma or non-small-cell lung cancer. These findings reveal a previously unknown mechanism of cancer immune evasion through mitochondrial transfer and can contribute to the development of future cancer immunotherapies.
en-copyright=
kn-copyright=

en-aut-name=IkedaHideki
en-aut-sei=Ikeda
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawaseKatsushige
en-aut-sei=Kawase
en-aut-mei=Katsushige
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishiTatsuya
en-aut-sei=Nishi
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WatanabeTomofumi
en-aut-sei=Watanabe
en-aut-mei=Tomofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakenagaKeizo
en-aut-sei=Takenaga
en-aut-mei=Keizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=InozumeTakashi
en-aut-sei=Inozume
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IshinoTakamasa
en-aut-sei=Ishino
en-aut-mei=Takamasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AkiSho
en-aut-sei=Aki
en-aut-mei=Sho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=LinJason
en-aut-sei=Lin
en-aut-mei=Jason
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KawashimaShusuke
en-aut-sei=Kawashima
en-aut-mei=Shusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NagasakiJoji
en-aut-sei=Nagasaki
en-aut-mei=Joji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=UedaYouki
en-aut-sei=Ueda
en-aut-mei=Youki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SuzukiShinichiro
en-aut-sei=Suzuki
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=MakinoshimaHideki
en-aut-sei=Makinoshima
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=ItamiMakiko
en-aut-sei=Itami
en-aut-mei=Makiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=NakamuraYuki
en-aut-sei=Nakamura
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=TatsumiYasutoshi
en-aut-sei=Tatsumi
en-aut-mei=Yasutoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=SuenagaYusuke
en-aut-sei=Suenaga
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=MorinagaTakao
en-aut-sei=Morinaga
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=Honobe-TabuchiAkiko
en-aut-sei=Honobe-Tabuchi
en-aut-mei=Akiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=OhnumaTakehiro
en-aut-sei=Ohnuma
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=KawamuraTatsuyoshi
en-aut-sei=Kawamura
en-aut-mei=Tatsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=UmedaYoshiyasu
en-aut-sei=Umeda
en-aut-mei=Yoshiyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

en-aut-name=NakamuraYasuhiro
en-aut-sei=Nakamura
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=24
ORCID=

en-aut-name=KiniwaYukiko
en-aut-sei=Kiniwa
en-aut-mei=Yukiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=25
ORCID=

en-aut-name=IchiharaEiki
en-aut-sei=Ichihara
en-aut-mei=Eiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=26
ORCID=

en-aut-name=HayashiHidetoshi
en-aut-sei=Hayashi
en-aut-mei=Hidetoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=27
ORCID=

en-aut-name=IkedaJun-ichiro
en-aut-sei=Ikeda
en-aut-mei=Jun-ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=28
ORCID=

en-aut-name=HanazawaToyoyuki
en-aut-sei=Hanazawa
en-aut-mei=Toyoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=29
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=30
ORCID=

en-aut-name=ManoHiroyuki
en-aut-sei=Mano
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=31
ORCID=

en-aut-name=SuzukiTakuji
en-aut-sei=Suzuki
en-aut-mei=Takuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=32
ORCID=

en-aut-name=OsawaTsuyoshi
en-aut-sei=Osawa
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=33
ORCID=

en-aut-name=KawazuMasahito
en-aut-sei=Kawazu
en-aut-mei=Masahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=34
ORCID=

en-aut-name=TogashiYosuke
en-aut-sei=Togashi
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=35
ORCID=

affil-num=1
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=2
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=3
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Division of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute
kn-affil=

affil-num=6
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=7
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Division of Nutriomics and Oncology, RCAST, The University of Tokyo
kn-affil=

affil-num=9
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=10
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan Department of Dermatology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=11
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Medical Oncology, Kindai University Faculty of Medicine
kn-affil=

affil-num=14
en-affil=Tsuruoka Metabolomics Laboratory, National Cancer Center
kn-affil=

affil-num=15
en-affil=Department of Surgical Pathology, Chiba Cancer Center
kn-affil=

affil-num=16
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=17
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=18
en-affil=Laboratory of Evolutionary Oncology, Chiba Cancer Center Research Institute
kn-affil=

affil-num=19
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=20
en-affil=Department of Dermatology, Faculty of Medicine, University of Yamanashi
kn-affil=

affil-num=21
en-affil=Department of Dermatology, Faculty of Medicine, University of Yamanashi
kn-affil=

affil-num=22
en-affil=Department of Dermatology, Faculty of Medicine, University of Yamanashi
kn-affil=

affil-num=23
en-affil=Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center
kn-affil=

affil-num=24
en-affil=Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center
kn-affil=

affil-num=25
en-affil=Department of Dermatology, Shinshu University School of Medicine
kn-affil=

affil-num=26
en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=27
en-affil=Department of Medical Oncology, Kindai University Faculty of Medicine
kn-affil=

affil-num=28
en-affil=Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=29
en-affil=Department of Otorhinolaryngology/Head and Neck Surgery, Chiba University Graduate School of Medicine
kn-affil=

affil-num=30
en-affil=Department of General Thoracic Surgery and Endocrinological Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=31
en-affil=Division of Cellular Signalling, National Cancer Center Research Institute
kn-affil=

affil-num=32
en-affil=Department of Respirology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=33
en-affil=Division of Nutriomics and Oncology, RCAST, The University of Tokyo
kn-affil=

affil-num=34
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=35
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=27502
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250728
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Autoantibody spark response predicts treatment outcome in patients receiving chemoradiation followed by durvalumab therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The PACIFIC regimen, comprising chemoradiotherapy (CRT) followed by maintenance with the immune checkpoint inhibitor (ICI) durvalumab, has become the standard of care for patients with unresectable non-small cell lung cancer (NSCLC). Although ICI is used to prevent recurrence by targeting residual microtumors, biomarkers capable of monitoring immune activity during this phase remain lacking. Here, we evaluated whether temporal changes in serum autoantibody levels can predict treatment efficacy. This retrospective study included 20 patients with unresectable stage II or III NSCLC who received the PACIFIC regimen. Serum autoantibodies against 130 antigens were quantified before CRT, after CRT, and two weeks after the first ICI dose. The primary outcome was progression-free survival (PFS), and its association with autoantibody dynamics was examined. We observed an immediate and strong autoantibody response (spark response [SR]) after ICI initiation in patients with favorable treatment outcomes. Patients with SR and programmed death ligand 1 (PD-L1) expression???50% showed better PFS (two-year PFS; 72.9% vs. 18.2%, p?=?0.0021). These findings suggest that serial monitoring of serum autoantibodies can provide a noninvasive approach to assess immune activity and predict treatment outcomes in patients receiving CRT or ICI therapy.
en-copyright=
kn-copyright=

en-aut-name=MoriTakeru
en-aut-sei=Mori
en-aut-mei=Takeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KitagawaMio
en-aut-sei=Kitagawa
en-aut-mei=Mio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HasegawaTomokazu
en-aut-sei=Hasegawa
en-aut-mei=Tomokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SomeyaMasanori
en-aut-sei=Someya
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsuchiyaTakaaki
en-aut-sei=Tsuchiya
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=GochoToshio
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en-title=アデノウイルスE1Aの発現増強はヒト食道がん細胞におけるTGF-β誘導性上皮間葉転換を抑制する
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affil-num=1
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en-title=Understanding the mesenchymal stem cell and its application to the study of human pluripotent stem cells
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affil-num=1
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affil-num=1
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en-aut-name=TakahashiYohei
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en-title=ヒト人工多能性幹細胞由来網膜色素上皮においてKCNJ13遺伝子の欠損は細胞配列と貪食能を障害する
kn-title=KCNJ13Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KanzakiYuki
en-aut-sei=Kanzaki
en-aut-mei=Yuki
kn-aut-name=神�ｱ勇希
kn-aut-sei=神�ｱ
kn-aut-mei=勇希
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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dt-pub-year=2020
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kn-subject=
en-title=腫瘍融解ウイルスはERKシグナルをターゲットにすることでヒト膵癌細胞の浸潤能を阻害する
kn-title=Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
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kn-copyright=

en-aut-name=KoujimaTakeshi
en-aut-sei=Koujima
en-aut-mei=Takeshi
kn-aut-name=國府島健
kn-aut-sei=國府島
kn-aut-mei=健
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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kn-subject=
en-title=Digitaria pruriens (Fisch. ex Trin.) B?se
kn-title=ヒトタバメヒシバ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
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kn-copyright=
en-keyword=イネ科 (Poaceae)
kn-keyword=イネ科 (Poaceae)
END

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kn-subject=
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kn-title=長鎖（約6 kb）lssODNおよびCRISPR / Cas9を用いたヒト科霊長類特異的lncRNAのマウス受精卵へのエレクトロポレーションによるノックイン
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kn-subtitle=
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kn-copyright=

en-aut-name=KondoHoshi
en-aut-sei=Kondo
en-aut-mei=Hoshi
kn-aut-name=近藤星
kn-aut-sei=近藤
kn-aut-mei=星
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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kn-subject=
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kn-title=機械的伸展刺激がヒト歯肉線維芽細胞と共培養したヒトiPS細胞由来心筋細胞の成熟に与える影響
en-subtitle=
kn-subtitle=
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kn-abstract=
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kn-copyright=

en-aut-name=IdeiHarumi
en-aut-sei=Idei
en-aut-mei=Harumi
kn-aut-name=出射明美
kn-aut-sei=出射
kn-aut-mei=明美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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kn-subject=
en-title=ヒト骨髄由来間葉系幹細胞の軟骨細胞分化に与えるDNAメチル化の影響
kn-title=DNA Methylation-Based Regulation of Human Bone Marrow-Derived Mesenchymal Stem/Progenitor Cell Chondrogenic Differentiation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NomuraYu
en-aut-sei=Nomura
en-aut-mei=Yu
kn-aut-name=野村優
kn-aut-sei=野村
kn-aut-mei=優
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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no-vol=
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dt-pub-year=2019
dt-pub=20190925
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en-subject=
kn-subject=
en-title=−腸内細菌叢解析およびメタボローム解析による評価−
kn-title=アルツハイマー型認知症患者の腸内細菌叢によるヒト型モデルマウスの構築とこの構築マウスの認知行動に腸内環境が及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujiiYusuke
en-aut-sei=Fujii
en-aut-mei=Yusuke
kn-aut-name=藤井祐介
kn-aut-sei=藤井
kn-aut-mei=祐介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

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kn-subject=
en-title=組織の炎症が引き起こす酸性条件がヒト骨髄由来間葉系幹細胞に及ぼす影響
kn-title=Acidic Pre-Conditioning Enhances the Stem Cell Phenotype of Human Bone Marrow Stem/Progenitor Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KunitomoYuri
en-aut-sei=Kunitomo
en-aut-mei=Yuri
kn-aut-name=國友由理
kn-aut-sei=國友
kn-aut-mei=由理
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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cd-journal=joma
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article-no=
start-page=26
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dt-pub-year=2019
dt-pub=20190329
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en-subject=
kn-subject=
en-title=
kn-title=ヒトによる道具製作とジェンダー : 『線具』としてのヒモへの注目から見えること
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
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kn-copyright=

en-aut-name=NakataniAyami
en-aut-sei=Nakatani
en-aut-mei=Ayami
kn-aut-name=中谷文美
kn-aut-sei=中谷
kn-aut-mei=文美
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=上羽陽子
kn-aut-sei=上羽
kn-aut-mei=陽子
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=金谷美和
kn-aut-sei=金谷
kn-aut-mei=美和
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学文学部

affil-num=2
en-affil=
kn-affil=国立民俗学博物館

affil-num=3
en-affil=
kn-affil=国立民俗学博物館
END

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dt-pub-year=2019
dt-pub=20190325
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kn-subject=
en-title=
kn-title=周期的伸展刺激と静水圧刺激に対するヒト歯根膜細胞の形態と配向の変化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
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kn-copyright=

en-aut-name=FujitaAyano
en-aut-sei=Fujita
en-aut-mei=Ayano
kn-aut-name=藤田彩乃
kn-aut-sei=藤田
kn-aut-mei=彩乃
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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dt-pub-year=2019
dt-pub=20190325
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kn-subject=
en-title=
kn-title=歯周病原細菌を原因とするヒトと伴侶動物の犬における人獣共通感染症検査に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TaiMasako
en-aut-sei=Tai
en-aut-mei=Masako
kn-aut-name=田井真砂子
kn-aut-sei=田井
kn-aut-mei=真砂子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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dt-accepted=
dt-pub-year=2018
dt-pub=20180927
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ベンジルイソチオシアネートの、メチル-β-シクロデキストリン及びMK571との組合せによるヒト大腸がん細胞での相乗的増殖抑制作用
kn-title=Synergistic antiproliferative effects of benzyl isothiocyanate in combination with methyl-β-cyclodextrin and MK571 in human colorectal cancer cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YangQifu
en-aut-sei=Yang
en-aut-mei=Qifu
kn-aut-name=楊祺福
kn-aut-sei=楊
kn-aut-mei=祺福
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

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dt-pub-year=2018
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kn-subject=
en-title=ヒトがん細胞株におけるOCT4 遺伝子発現の決定的な証拠: OCT4陽性細胞集団の機能検証
kn-title=Conclusive Evidence for OCT4 Transcription in Human Cancer Cell Lines: Possible Role of a Small OCT4-Positive Cancer Cell Population
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MiyamotoTomoyuki
en-aut-sei=Miyamoto
en-aut-mei=Tomoyuki
kn-aut-name=宮本朋幸
kn-aut-sei=宮本
kn-aut-mei=朋幸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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dt-pub-year=2018
dt-pub=20180323
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en-subject=
kn-subject=
en-title=構成的アンドロスタン受容体活性物質モムフルオロスリンによるラット肝発がん性のヒトへのリスク評価
kn-title=Human Risk Assessment for Rat Liver Tumors Induced by a Constitutive Androstane Receptor Activator Momfluorothrin
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkudaYu
en-aut-sei=Okuda
en-aut-mei=Yu
kn-aut-name=奥田優
kn-aut-sei=奥田
kn-aut-mei=優
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
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dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ヒト歯肉線維芽細胞との共培養がiPS細胞の心筋細胞への成熟に与える影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsudaYusuke
en-aut-sei=Matsuda
en-aut-mei=Yusuke
kn-aut-name=松田祐典
kn-aut-sei=松田
kn-aut-mei=祐典
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
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cd-vols=
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dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト骨格形成細胞分化におけるurothelial cancer-associated 1長鎖ノンコーディングRNAの生理的役割
kn-title=Physiological role of urothelial cancer-associated 1 long noncoding RNA in human skeletogenic cell differentiation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshikawaTakanori
en-aut-sei=Ishikawa
en-aut-mei=Takanori
kn-aut-name=石川崇典
kn-aut-sei=石川
kn-aut-mei=崇典
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
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dt-revised=
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dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=真菌二次代謝産物(+)-terreinがAggregatibacter actinomycetemcomitans刺激時にヒト歯肉上皮細胞に及ぼす影響の解明
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakamuraArisa
en-aut-sei=Nakamura
en-aut-mei=Arisa
kn-aut-name=中村亜里紗
kn-aut-sei=中村
kn-aut-mei=亜里紗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=JAK阻害剤のメカニカルストレスによるヒト軟骨細胞からの蛋白分解酵素発現抑制
kn-title=Inhibitory effect of JAK inhibitor on mechanical stress-induced protease expression by human articular chondrocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MachidaTakahiro
en-aut-sei=Machida
en-aut-mei=Takahiro
kn-aut-name=町田崇博
kn-aut-sei=町田
kn-aut-mei=崇博
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=107
cd-vols=
no-issue=
article-no=
start-page=5
end-page=10
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Alzheimer’s disease : Relationship between the Alzheimer’s disease and human microbiome
kn-title=アルツハイマー病の背景と発症 : ヒトマイクロバイオーム（細菌叢）との関連の視点から
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Alzheimer’s disease (AD) is a progressive, neurodegenerative disease characterized by memory and language disorder. The accumulation of senile plaques called β-amyloid and neurofibrillary tangles involving protein tau in the brains of AD patients have been considered as two hallmarks of AD. In AD, it is reported that accumulation of β-amyloid may be observed 25 years before onset, supporting early diagnosis and treatment by brain image analysis, because several techniques have recently been developed to detect β-amyloid and tau protein in brains of persons diagnosed with AD. AD patients are usually suffering from other diseases such as diabetes or periodontal disease, and there is accumulating data to show that these diseases associate with the human microbiome, such as gut and oral microbiota. In this report, the relation ship between AD and the human microbiome is reviewed.
en-copyright=
kn-copyright=

en-aut-name=FujiiYusuke
en-aut-sei=Fujii
en-aut-mei=Yusuke
kn-aut-name=藤井祐介
kn-aut-sei=藤井
kn-aut-mei=祐介
aut-affil-num=1
ORCID=

en-aut-name=MoritaHidetoshi
en-aut-sei=Morita
en-aut-mei=Hidetoshi
kn-aut-name=森田英利
kn-aut-sei=森田
kn-aut-mei=英利
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院　環境生命科学研究科

affil-num=2
en-affil=
kn-affil=岡山大学大学院　環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170929
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト大腸がん細胞のベンジルイソチオシアネート耐性機構へのホスファチジルイノシトール 3-キナーゼの関与
kn-title=Involvement of phosphatidylinositide 3-kinase pathway in the resistant mechanisms against benzyl isothiocyanate in human colorectal cancer cells
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kn-title=ヒト歯肉線維芽細胞のリソソーム酵素カテプシンB，L分泌に対するIL-6が及ぼす影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=GotoAyaka
en-aut-sei=Goto
en-aut-mei=Ayaka
kn-aut-name=後藤絢香
kn-aut-sei=後藤
kn-aut-mei=絢香
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院
END

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cd-journal=joma
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dt-pub-year=2014
dt-pub=20141231
dt-online=
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kn-subject=
en-title=日本人において、ヒトRhoグアニンヌクレオチド交換因子（ARHGEF）11遺伝子は、統合失調症の発症と関連している
kn-title=Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MizukiYutaka
en-aut-sei=Mizuki
en-aut-mei=Yutaka
kn-aut-name=水木寛
kn-aut-sei=水木
kn-aut-mei=寛
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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dt-pub-year=2014
dt-pub=20140630
dt-online=
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kn-article=
en-subject=
kn-subject=
en-title=アスコルビン酸-2グルコシド添加のUW液を用いて凍結保存した、ヒト膵島の血糖感受性インシュリン分泌能維持について
kn-title=Maintenance of Glucose-sensitive Insulin Secretion of Cryopreserved Human Islets with University of Wisconsin Solution and Ascorbic Acid-2 Glucoside
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ArataTakashi
en-aut-sei=Arata
en-aut-mei=Takashi
kn-aut-name=荒田尚
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kn-aut-mei=尚
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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dt-pub-year=2014
dt-pub=20140325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒトの視聴覚時間統合メカニズムに関するERP研究
kn-title=Studies on Human Mechanism of Audiovisual Temporal Integration by Event-related Potential
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=楊菁　菁
kn-aut-sei=楊
kn-aut-mei=菁　菁
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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dt-pub-year=2014
dt-pub=20140325
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kn-subject=
en-title=3社製品間における注射用蒸留水中の光重合開始剤の 1-hydroxycyclohexyl phenyl ketoneの定量とヒト単核球に対する細胞毒性に関する研究
kn-title=Quantitation and Human Monocyte Cytotoxicity of the Polymerization Agent 1-Hydroxycyclohexyl Phenyl Ketone (Irgacure 184) from Three Brands of Aqueous Injection Solution
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
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kn-copyright=

en-aut-name=YamajiKazuhiko
en-aut-sei=Yamaji
en-aut-mei=Kazuhiko
kn-aut-name=山路和彦
kn-aut-sei=山路
kn-aut-mei=和彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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dt-pub-year=2014
dt-pub=20140325
dt-online=
en-article=
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en-subject=
kn-subject=
en-title=ヒト悪性腫瘍におけるREIC/Dkk-3遺伝子のDNAメチル化の検討
kn-title=DNA methylation status of REIC/Dkk-3 gene in human malignancies
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HayashiTatsuro
en-aut-sei=Hayashi
en-aut-mei=Tatsuro
kn-aut-name=林達朗
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kn-aut-mei=達朗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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dt-pub-year=2013
dt-pub=20130930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒトの視覚物体知覚脳機能メカニズムに関するfMRI研究
kn-title=fMRI Studies on the Human Brain Mechanism of Visual Object Perception
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WangBin
en-aut-sei=Wang
en-aut-mei=Bin
kn-aut-name=王彬
kn-aut-sei=王
kn-aut-mei=彬
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
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dt-received=
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dt-pub-year=2013
dt-pub=20130630
dt-online=
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en-subject=
kn-subject=
en-title=p53の転写活性化によって誘導される２種類のプログラム細胞死の誘導機構はヒト骨肉腫細胞における腫瘍融解アデノウイルスへの耐性を克服する
kn-title=Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HaseiJo
en-aut-sei=Hasei
en-aut-mei=Jo
kn-aut-name=長谷井嬢
kn-aut-sei=長谷井
kn-aut-mei=嬢
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
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cd-vols=
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dt-received=
dt-revised=
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dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=簡単なヒト少数精子ガラス化凍結保存法の確立とその臨床応用
kn-title=Simple vitrification for small numbers of human spermatozoa involving clinical outcomes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=EndoYuji
en-aut-sei=Endo
en-aut-mei=Yuji
kn-aut-name=遠藤雄史
kn-aut-sei=遠藤
kn-aut-mei=雄史
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
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cd-vols=
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dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=口唇腺を用いたシェーグレン症候群におけるヒトβディフェンシンの発現パターン分析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakedaSeiko
en-aut-sei=Takeda
en-aut-mei=Seiko
kn-aut-name=武田斉子
kn-aut-sei=武田
kn-aut-mei=斉子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ヒト歯肉線維芽細胞におけるIL-6および可溶型IL-6受容体誘導性angiogenin産生に血管新生阻害物質terreinが及ぼす効果に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamamotoDaisuke
en-aut-sei=Yamamoto
en-aut-mei=Daisuke
kn-aut-name=山本大介
kn-aut-sei=山本
kn-aut-mei=大介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
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dt-received=
dt-revised=
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dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Methanobrevibacter oralis およびヒトのグループIIシャペロニンに対する免疫応答の解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HiraiKimito
en-aut-sei=Hirai
en-aut-mei=Kimito
kn-aut-name=平井公人
kn-aut-sei=平井
kn-aut-mei=公人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
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dt-accepted=
dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=培養ヒト軟骨細胞においてヒストン脱アセチル化酵素阻害薬は、メカニカルストレスにより亢進したRUNX-2とADAMTS-5の発現を、MAPK経路を阻害することにより抑制する
kn-title=Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SaitoTaichi
en-aut-sei=Saito
en-aut-mei=Taichi
kn-aut-name=齋藤太一
kn-aut-sei=齋藤
kn-aut-mei=太一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト口腔癌細胞HSC-4における5-アミノレブリン酸を用いた光線力学的治療法の細胞障害作用の改善
kn-title=Improvement of the Efficacy of 5-aminolevulinic Acid-mediated Photodynamic Treatment in Human Oral Squamous Cell Carcinoma HSC-4
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamamotoMasanao
en-aut-sei=Yamamoto
en-aut-mei=Masanao
kn-aut-name=山本昌直
kn-aut-sei=山本
kn-aut-mei=昌直
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120927
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト癌細胞におけるトラスツヅマブ耐性機構の解析とHER2細胞外ドメイン発現によるADCC活性増強を介した感受性誘導
kn-title=Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YoshidaRyosuke
en-aut-sei=Yoshida
en-aut-mei=Ryosuke
kn-aut-name=吉田亮介
kn-aut-sei=吉田
kn-aut-mei=亮介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=3
article-no=
start-page=231
end-page=238
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20121203
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=HuH-7 cell line established from a highly differentiated human hepatocellular carcinoma
kn-title=高分化型ヒト肝癌由来細胞株“HuH-7”
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=高分化型ヒト肝癌由来細胞株“HuH-7”は，1982年にCancer Researchにその樹立を報告した．HuH-7は，当時の岡山大学医学部附属癌源研究施設病理部門（故佐藤二郎教授）の下で樹立し，これまで多くの研究分野で利用され，世界的に有名な肝癌細胞株となっている．本稿では，有用性の高い分化機能を有するヒト肝癌細胞株HuH-7について，肝細胞癌の腫瘍マーカーであるα-fetoprotein（AFP）を中心に，この細胞株を用いた研究分野に関する詳細を紹介する．
en-copyright=
kn-copyright=

en-aut-name=NakabayashiHidekazu
en-aut-sei=Nakabayashi
en-aut-mei=Hidekazu
kn-aut-name=中林秀和
kn-aut-sei=中林
kn-aut-mei=秀和
aut-affil-num=1
ORCID=

en-aut-name=TaketaKazuhisa
en-aut-sei=Taketa
en-aut-mei=Kazuhisa
kn-aut-name=武田和久
kn-aut-sei=武田
kn-aut-mei=和久
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=北海道情報大学　医療情報学科

affil-num=2
en-affil=
kn-affil=介護老人保健施設　仁和の里
en-keyword=肝細胞癌
kn-keyword=肝細胞癌
en-keyword=培養細胞
kn-keyword=培養細胞
en-keyword=α-フェトプロテイン
kn-keyword=α-フェトプロテイン
en-keyword=HuH-7
kn-keyword=HuH-7
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=2
article-no=
start-page=105
end-page=110
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas
kn-title=テロメラーゼ依存性腫瘍融解ウイルス療法の骨・軟部肉腫に対する前臨床的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=骨・軟部肉腫は, 一部に治療抵抗性で予後の悪い症例が存在するため, 新たな治療法の確立が重要な課題である.　我々は, 5型アデノウイルスを基本骨格として, テロメラーゼ活性に依存して増殖する腫瘍融解ウイルス（OBP-301）や, coxsackie and adenovirus receptor（CAR）陰性の腫瘍細胞に感染するファイバー改変型ウイルス（OBP-405）を用い, 骨・軟部肉腫細胞に対する抗腫瘍効果を検討した.　
　14種類の骨・軟部肉腫細胞株に対してOBP-301の細胞障害活性を検討し, 12種類の細胞株でOBP-301に感受性を認めた.　また, OBP-301の細胞障害活性はCARの発現と相関していた.　さらに, テロメラーゼ活性の低い細胞に対しても, 5型アデノウイルスの複製に必須のE1Aによりテロメラーゼ活性の増強効果がおこり, 強い抗腫瘍活性を示すことを明らかにした.　次に, 骨肉腫脛骨同所性移植動物モデルを作成しOBP-301を投与したところ, OBP-301投与群では対象群と比べて有意に腫瘍増殖を抑制した.　最後に, OBP-301に感受性を認めなかったCAR陰性細胞株に対してOBP-405を用いて検討し, OBP-405が有効に作用することを確認した.　
　OBP-301やOBP-405を用いたウイルス療法は, 骨・軟部肉腫に対する新たな治療法となる可能性がある.　
en-copyright=
kn-copyright=

en-aut-name=SasakiTsuyoshi
en-aut-sei=Sasaki
en-aut-mei=Tsuyoshi
kn-aut-name=佐々木剛
kn-aut-sei=佐々木
kn-aut-mei=剛
aut-affil-num=1
ORCID=

en-aut-name=TazawaHiroshi
en-aut-sei=Tazawa
en-aut-mei=Hiroshi
kn-aut-name=田澤大
kn-aut-sei=田澤
kn-aut-mei=大
aut-affil-num=2
ORCID=

en-aut-name=HaseiJo
en-aut-sei=Hasei
en-aut-mei=Jo
kn-aut-name=長谷井嬢
kn-aut-sei=長谷井
kn-aut-mei=嬢
aut-affil-num=3
ORCID=

en-aut-name=KunisadaToshiyuki
en-aut-sei=Kunisada
en-aut-mei=Toshiyuki
kn-aut-name=国定俊之
kn-aut-sei=国定
kn-aut-mei=俊之
aut-affil-num=4
ORCID=

en-aut-name=YoshidaAki
en-aut-sei=Yoshida
en-aut-mei=Aki
kn-aut-name=吉田晶
kn-aut-sei=吉田
kn-aut-mei=晶
aut-affil-num=5
ORCID=

en-aut-name=HashimotoYuuri
en-aut-sei=Hashimoto
en-aut-mei=Yuuri
kn-aut-name=橋本悠里
kn-aut-sei=橋本
kn-aut-mei=悠里
aut-affil-num=6
ORCID=

en-aut-name=YanoShuya
en-aut-sei=Yano
en-aut-mei=Shuya
kn-aut-name=矢野修也
kn-aut-sei=矢野
kn-aut-mei=修也
aut-affil-num=7
ORCID=

en-aut-name=YoshidaRyosuke
en-aut-sei=Yoshida
en-aut-mei=Ryosuke
kn-aut-name=吉田亮介
kn-aut-sei=吉田
kn-aut-mei=亮介
aut-affil-num=8
ORCID=

en-aut-name=UnoFutoshi
en-aut-sei=Uno
en-aut-mei=Futoshi
kn-aut-name=宇野太
kn-aut-sei=宇野
kn-aut-mei=太
aut-affil-num=9
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=香川俊輔
kn-aut-sei=香川
kn-aut-mei=俊輔
aut-affil-num=10
ORCID=

en-aut-name=MorimotoYuki
en-aut-sei=Morimoto
en-aut-mei=Yuki
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ORCID=

en-aut-name=UrataYasuo
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en-aut-name=FujiwaraToshiyoshi
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en-aut-name=OzakiToshifumi
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kn-aut-mei=敏文
aut-affil-num=14
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=12
en-affil=
kn-affil=オンコリスバイオファーマ

affil-num=13
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=14
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学
en-keyword=アデノウイルス
kn-keyword=アデノウイルス
en-keyword=肉腫
kn-keyword=肉腫
en-keyword=ALT
kn-keyword=ALT
en-keyword=ヒトテロメラーゼ逆転写酵素
kn-keyword=ヒトテロメラーゼ逆転写酵素
END

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dt-pub-year=2012
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en-title=
kn-title=ヒトUDP-グルクロン酸転移ヒトUDP-グルクロン酸転移酵素UGT2B7の触媒機能におけるN-結合型糖鎖修飾の役割
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NagaokaKenjiro
en-aut-sei=Nagaoka
en-aut-mei=Kenjiro
kn-aut-name=長岡憲次郎
kn-aut-sei=長岡
kn-aut-mei=憲次郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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dt-pub-year=2012
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kn-subject=
en-title=
kn-title=化学物質の光毒性・光遺伝毒性試験における培養ヒトケラチノサイトの有用性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HorinouchiMayumi
en-aut-sei=Horinouchi
en-aut-mei=Mayumi
kn-aut-name=堀ノ内眞弓
kn-aut-sei=堀ノ内
kn-aut-mei=眞弓
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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dt-pub-year=2012
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kn-subject=
en-title=
kn-title=Stage-specific embryonic antigen-4を用いたヒト乳歯歯根膜幹細胞の同定
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FukushimaHiroaki
en-aut-sei=Fukushima
en-aut-mei=Hiroaki
kn-aut-name=福島宏明
kn-aut-sei=福島
kn-aut-mei=宏明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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dt-pub-year=2012
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kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Eosinophil Cationic Proteinが正常ヒト線維芽細胞に及ぼす影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SatoTakamaro
en-aut-sei=Sato
en-aut-mei=Takamaro
kn-aut-name=佐藤公麿
kn-aut-sei=佐藤
kn-aut-mei=公麿
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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dt-pub-year=2012
dt-pub=20120323
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en-subject=
kn-subject=
en-title=
kn-title=活性型Matrix metalloproteinase-3がヒト単球系細胞株THP-1における可溶型インターロイキン-6受容体の産生に及ぼす影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KobayashiHiroya
en-aut-sei=Kobayashi
en-aut-mei=Hiroya
kn-aut-name=小林寛也
kn-aut-sei=小林
kn-aut-mei=寛也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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dt-pub-year=2012
dt-pub=20120323
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en-subject=
kn-subject=
en-title=周期的伸張負荷がヒト前十字靭帯細胞のCCN2/CTGF発現を活性化する
kn-title=Mechanical stretch increases CCN2/CTGF expression in anterior cruciate ligament-derived cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MiyakeYoshiaki
en-aut-sei=Miyake
en-aut-mei=Yoshiaki
kn-aut-name=三宅由晃
kn-aut-sei=三宅
kn-aut-mei=由晃
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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dt-pub-year=2012
dt-pub=20120323
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en-subject=
kn-subject=
en-title=TP53変異の有無が異なるヒトのリンパ芽球様細胞株間における5-fluorouracilに対する遺伝毒性及び遺伝子発現への反応性の差
kn-title=Different responses to 5-fluoraouracil in mutagenicity and gene expression between two human lymphoblastoid cell lines with or without TP53 mutation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkaHiroaki
en-aut-sei=Oka
en-aut-mei=Hiroaki
kn-aut-name=岡宏昭
kn-aut-sei=岡
kn-aut-mei=宏昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
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cd-vols=
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dt-accepted=
dt-pub-year=2012
dt-pub=20120323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト悪性グリオーマの浸潤と血管新生を模倣する新規グリオーマ動物モデルの検討
kn-title=Novel animal glioma models that separately exhibit two different invasive and angiogenic phenotypes of human glioblastomas
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=InoueSatoshi
en-aut-sei=Inoue
en-aut-mei=Satoshi
kn-aut-name=井上智
kn-aut-sei=井上
kn-aut-mei=智
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=32
cd-vols=
no-issue=4
article-no=
start-page=365
end-page=372
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=1990
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Assay of GBM antigen in urine and serum with an anti-human renal monoclonal antibody
kn-title=抗ヒト腎モノクローナル抗体を用いた尿中及び血中のGBM抗原の測定 第2編
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using a monoclonal antibody (Mab-G3) recognizing glomerular basement membrane (GBM), we assayed GBM antigen (G3-Ag) in the urine and serum of renal disease patients by sandwich ELISA. The subjects included normal control (NOR), minimal change nephrotic syndrome (MCNS), IgA nephropathy (IgA), membranous nephropathy (MN), membranoproliferative glomerulonephritis (MPGN) and chronic renal failure (CRF). The urine and serum was used as the material. With urinary G3-Ag, there were no statistically significant differences among the NOR, MCNS, IgA, MN, MPGN and CRF groups. Although no correlation was observed with proteinuria, hematuria, serum creatinine, serum β2 microglobulin and urinary NAG, urinary G3-Ag showed a significant (p<0.05) increase in excretion in the group of progressive CRF patients with s-Cr more than 1.0 mg/dl/month as compared to the stationary CRF group with s-Cr<1.0 mg/dl/month. Serum G3-Ag showed lower values in almost all cases, and there were no significant differences among the renal disease groups. The above findings led us to believe that the assay of urinary G3-Ag was useful in determining the degree of GBM disorder. It was also presumed that assay of renal antigens in urine and serum with the respective anti-human renal monoclonal antibodies could be a new tool in diagnosing renal diseases.
en-copyright=
kn-copyright=

en-aut-name=MinoYasuaki
en-aut-sei=Mino
en-aut-mei=Yasuaki
kn-aut-name=味埜泰明
kn-aut-sei=味埜
kn-aut-mei=泰明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第三内科
en-keyword=monoclonal antibody
kn-keyword=monoclonal antibody
en-keyword=sandwich ELISA
kn-keyword=sandwich ELISA
en-keyword=GBM antigen
kn-keyword=GBM antigen
en-keyword=renal disease
kn-keyword=renal disease
END

start-ver=1.4
cd-journal=joma
no-vol=32
cd-vols=
no-issue=4
article-no=
start-page=353
end-page=364
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=1990
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study on the change of glomerular antigenicity in various renal diseases with anti-human renal monoclonal antibodies
kn-title=抗ヒト腎モノクローナノレ抗体を用いた疾患腎における抗原性の変化の検討 第1編
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We produced 22 different kinds of monoclonal antibody (Mab) by immunizing mice with human GBM antigens. In these Mabs, Mab-G1 to G5 recognized only GBM in the glomerulas, Mab-E1 and E2 recognized only glomerular epithelial cells, and Mab-M1 to M4 recognized mainly mesangium. The reactions of these Mabs with known GBM antigens such as type IV collagen, fibronectin and laminin were negative by immunoblotting. Using Mab-G1, Mab-E1 and Mab-M1, changes in the antigenicity of antigens recognized by Mabs were examined on kidney sections from the patients with various renal diseases by the indirect immunofluorescence test. When Mab-G1 recognizing GBM was used, there was no particular change of anti-genicity in minimal change nephrotic syndrome (MCNS) and IgA nephropathy (IgA), whereas in membranous nephropathy (MN) thickened GBM was found to maintain anti-genicity and the region of deposits was observed as negative punched-out region. In type I and III of membranoproliferative glomerulonephritis (MPGN), GBM was observed only outside of subendothlial deposits without showing double contour. In type II MPGN, GBM showed a double linear pattern and antigenicity of GBM in regions of dense deposits was not detected. When Mab-E1 recognizing glomerular epithelial cells was used, there was no change of antigenicity in the renal diseases. Further, in crescentic glomerulone-phritis, the region of the cellular crescents was not stained, When Mab-M1 recognizing mesangium was used, extensive staining was observed in the increased mesangium in IgA, MPGN, and diabetic nephropathy. We feel that it is of significance in elucidating the pathogenesis of renal diseases to study the changes of glomerular antigenicity in diseased kidneys by using anti-human renal monoclonal antibodies.
en-copyright=
kn-copyright=

en-aut-name=MinoYasuaki
en-aut-sei=Mino
en-aut-mei=Yasuaki
kn-aut-name=味埜泰明
kn-aut-sei=味埜
kn-aut-mei=泰明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第三内科
en-keyword=monoclonal antibody
kn-keyword=monoclonal antibody
en-keyword=human kidney antigen
kn-keyword=human kidney antigen
en-keyword=GBM
kn-keyword=GBM
en-keyword=mesangium
kn-keyword=mesangium
en-keyword=glomerular epithelial cell
kn-keyword=glomerular epithelial cell
END

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cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20111231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト変形性関節症軟骨におけるHigh-mobility Group Box Chromosomal Protein-1(HMGB-1)の発現と局在
kn-title=Gene Expression and Localization of High-mobility Group Box Chromosomal Protein-1 (HMGB-1) in Human Osteoarthritic Cartilage
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TeradaChuji
en-aut-sei=Terada
en-aut-mei=Chuji
kn-aut-name=寺田忠司
kn-aut-sei=寺田
kn-aut-mei=忠司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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cd-vols=
no-issue=
article-no=
start-page=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=樹状細胞サブセットとヒト乳頭腫ウイルス関連皮膚病変での免疫環境
kn-title=Dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakayamaYumi
en-aut-sei=Nakayama
en-aut-mei=Yumi
kn-aut-name=中山由美
kn-aut-sei=中山
kn-aut-mei=由美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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no-issue=
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start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=テロメラーゼ依存的腫瘍融解アデノウイルス製剤によるDNA修復阻害を介したヒト癌細胞の放射線感受性増強作用
kn-title=Telomerase-Dependent Oncolytic Adenovirus Sensitizes Human Cancer Cells to Ionizing Radiation via Inhibition of DNA Repair Machinery
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KurodaShinji
en-aut-sei=Kuroda
en-aut-mei=Shinji
kn-aut-name=黒田新士
kn-aut-sei=黒田
kn-aut-mei=新士
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト大腸癌細胞株SW620におけるCD133陽性細胞の特性
kn-title=Characteristics of CD133(+) human colon cancer SW620 cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KawamotoHironobu
en-aut-sei=Kawamoto
en-aut-mei=Hironobu
kn-aut-name=河本洋伸
kn-aut-sei=河本
kn-aut-mei=洋伸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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cd-vols=
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article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=人工骨補填材(MASTERGRAFT? Granules)を用いて治療を行ったヒト抜歯窩の組織学的評価−基礎研究−
kn-title=Histological evaluation of human alveolar sockets treated with artificial bone substitute material(MASTERGRAFT? Granules).-A preliminary study-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WakimotoMari
en-aut-sei=Wakimoto
en-aut-mei=Mari
kn-aut-name=脇本真理
kn-aut-sei=脇本
kn-aut-mei=真理
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=機能的核磁気共鳴画像法を用いたヒトの広視野の視覚メカニズムに関する研究
kn-title=Studies on the Human Visual Mechanism of Wide-field  by Functional Magnetic Resonance Imaging
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=閻天翼
kn-aut-sei=閻
kn-aut-mei=天翼
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20101231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト固形癌に対する、作用機序の異なる2剤併用ウイルス療法の前臨床評価
kn-title=Preclinical Evaluation of Differentially Targeting Dual Virotherapy for Human Solid Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SakaiRyo
en-aut-sei=Sakai
en-aut-mei=Ryo
kn-aut-name=酒井亮
kn-aut-sei=酒井
kn-aut-mei=亮
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒトリンパ球混合培養反応における、AGE誘導性接着分子発見、サイトカイン産生、リンパ球増殖に対するヒスタミンの抑制効果の検討
kn-title=Histamine inhibits adhesion molecule expression in human monocytes, induced by advanced glycation end products, during the mixed lymphocyte reaction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ZhangJiyong
en-aut-sei=Zhang
en-aut-mei=Jiyong
kn-aut-name=張継勇
kn-aut-sei=張
kn-aut-mei=継勇
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=6-2
article-no=
start-page=3187
end-page=3191
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590515
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Free Amino-Acids in the Brain (X) on the free amino-acids and related substances in various parts in the mature and foetal human brains
kn-title=脳の遊離アミノ酸について(X) 成熟ヒト脳およびヒト胎児脳各部位における遊離アミノ酸およびその関連物質について
en-subtitle=
kn-subtitle=
en-abstract=With the brains of foetuses on the fifth gravid month and on the eighth gravid month the author isolated and estimated the free amino-acids and related substances at various parts of these brains by means of the ion-exchange chromatography, and conducted the same investigations with the normal tissues surrounding the tumor of the frontal lobe in the brain of an 18-year-old patient with tubosclerosis. 1. The quantities of free amino-acids in the foetal brains differ significantly from those in the mature human brain. 2. In the foetal brain, with some variations according to sites, amino-acids such as taurine, phosphoethanolamine, glycine and alanine, generally tend to decrease with the advance in age, while glutaminic, aspartic and γ-amino-butyric acids tend to increase. 3. In either one of the foetal brains γ-amino-butyric acid is detected in a largest quantity in the hypothalamus. 4. Cystathionine which is often detected in a large quantity in the human brain after birth can hardly be recognized in the foetal brain.
kn-abstract=イオン交換クロマトグラフイーをもちいて,妊娠5ケ月および8ケ月胎児脳の各部位ならびに18才結節性硬化症患者脳の前頭葉,腫瘍周辺の非結節性組織について遊離アミノ酸およびその関連物質を各々分離定量した. 1) 妊娠5ケ月なうびに8ケ月胎児脳と成熟ヒト脳を比較すると,胎児脳と生後ヒト脳との間にはその遊離アミノ酸量にかなり著明な差異を認める. 2) 胎児脳では,脳各部位ともに多少の例外はあるが,生育の段階につれてタウリン,ホスホエタノラミン,グリシン,アラニン等は減少し,グルタミン酸,アスパラギン酸, γ-アミノ酪酸等は増加する傾向を示している. 3) γ-アミノ酪酸は胎児脳のいずれでも,視床下部で最高値を示した. 4) 生後のヒト脳で多量に測定され得るシスタチオニンは胎児脳にはほとんど存在しない.
en-copyright=
kn-copyright=

en-aut-name=FukaiNobuhiro
en-aut-sei=Fukai
en-aut-mei=Nobuhiro
kn-aut-name=深井延浩
kn-aut-sei=深井
kn-aut-mei=延浩
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=4-1
article-no=
start-page=1591
end-page=1594
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Free Amino Acids in the Brain Part VII Estimation of Free Amino Acids in the Human Brain by the Ion-Exchange Chromatography
kn-title=脳の遊離アミノ酸について (VII) イオン交換クロマトグラフイーによるヒト脳遊離アミノ酸の定量
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By means of the ion-exchange chromatography free amino acids and their related compounds in the fresh brain tissue have been estimated. As for the test material, pieces of the cerebral cortex sectioned at the time of the surgical operation in the patients with cerebral tumor or with epilepsy are used. As the result we have obtained the following notworthy differences when compared with the results previously reported by us concerning several species of mammalians. They are: (1) In the human brain there is a conciderable amount of cystathionine. Namely, 19.4 to 43.2mg/100g wet weight, and this substance is far smaller or not recognizable in other animals; and (2) the amounts of γ-aminobutric acid and taurine are a good deal smaller than animals. Moreover, in general the pattern of the free amino acids in the human cerebral cortex may be said to resemble closely that in dog.
en-copyright=
kn-copyright=

en-aut-name=YunoueShigeru
en-aut-sei=Yunoue
en-aut-mei=Shigeru
kn-aut-name=湯之上茂
kn-aut-sei=湯之上
kn-aut-mei=茂
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=7-8
article-no=
start-page=687
end-page=698
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=19890831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Purification and characterization of HBs antigen from hepatoma huGK-14 cell line
kn-title=ヒト培養肝癌細胞の産生するHBs抗原の精製方法とその物理化学的特性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=HBs antigen was purified from the culture fluid of hepatoma huGK-14 cell line and its physico-chemical properties were studied. The purification consists of following steps: concentration of culture fluid by membrane filtration, affinity column chromatography (anti-HBs monoclonal antibody column and anti-human serum albumin antibody column), and ultracentrifugation (isopycnic centrifugation in CsCl density gradient and rate zonal centrifugation on sucrose gradient). Highly purified (purity>99%) HBs antigen was isolated with an overall yield of about 40%. The HBs antigen showed uniform spherical particles (diameter: 23.2±2.9nm) and had a specific gravity of 1.20g/cm3. The purified HBs antigen yielded, in SDS-PAGE (under reducing conditions), four protein bands with apparent molecular weights of 22,000 and 26,000 (the two major bands), and 44,000 and 47,000. The two proteins of molecular weights of 26,000 and 47,000 are likely to be glycosylated, as these were several fold reduced when the cells were cultured in the presence of Tunicamycin. Amino acid analysis, Edman degradation, carboxypeptidase digestion, and ultraviolet absorption spectrum indicated that the HBs antigen from hepatoma cells is very similar to that derived from human plasma.
en-copyright=
kn-copyright=

en-aut-name=OdaMunehiro
en-aut-sei=Oda
en-aut-mei=Munehiro
kn-aut-name=小田宗宏
kn-aut-sei=小田
kn-aut-mei=宗宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌源病理学教室
en-keyword=Hepatoma
kn-keyword=Hepatoma
en-keyword=Cell culture
kn-keyword=Cell culture
en-keyword=HBs antigen
kn-keyword=HBs antigen
en-keyword=Purification
kn-keyword=Purification
en-keyword=Characterization
kn-keyword=Characterization
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=5-6
article-no=
start-page=589
end-page=602
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Abnormality of dominant oncogenes and recessive oncogenes in human bone and soft tissue tumors
kn-title=ヒト骨・軟部腫瘍における優性および劣性癌遺伝子の変異に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Osteosarcoma is a malignant bone tumor which usually occurs in the metaphysis of long bones in adolescents or young adults, but the mechanism of disease occurrence is unknown. To examine alterations in the dominant oncogenes in the osteosarcoma and other bone and soft tissue tumors, DNA extracted from 12 bone tumors, 12 soft part tumors and 2 cells lines was hybridized with c-oncogene (c-myc, c-sis, c-raf-1, c-fos, K-ras2, c-erbB, c-fms, c-fos). DNA extracted from the same samples was examined with Rb cDNA (p0.9R, p3.8R) probes, the retinoblastoma gene (Rb gene) localized at 13q14, to analize whether a recessive mutation is a target in osteosarcoma, and other bone and soft tissue tumors. Amplification of c-myc was observed in 3 cases from 7 osteosarcomas and abnormalities in structure of the Rb gene were found in 4 from 7 osteosarcomas, 2 from 4 MFH, and 1 from 2 Ewing's sarcomas. Both amplification of the c-myc and abnormalities of the Rb gene were observed in 3 osteosarcoma cases. The results indicated that both the Rb gene and c-myc oncogene may be involved in the initiation of osteosarcoma.
en-copyright=
kn-copyright=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=尾崎敏文
kn-aut-sei=尾崎
kn-aut-mei=敏文
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属癌源研究施設生化学研究部門
en-keyword=骨・軟部腫瘍
kn-keyword=骨・軟部腫瘍
en-keyword=優性癌遺伝子
kn-keyword=優性癌遺伝子
en-keyword=劣性癌遺伝子
kn-keyword=劣性癌遺伝子
en-keyword=Rb遺伝子
kn-keyword=Rb遺伝子
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=5-6
article-no=
start-page=581
end-page=588
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of the treatment of pulmonary epidermoid carcinoma Part 2. Thermochemotherapy in human epidermoid carcinoma cells in culture
kn-title=肺扁平上皮癌の治療に関する研究 第2編 ヒト肺扁平上皮癌細胞株を用いた温熱化学療法に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effectiveness of hyperthermia in combination with anticancer drugs on EBC-1 cell line established from a patient with pulmonary epidermoid carcinoma was investigated. Anticancer drugs tested in the present study were adriamycin, bleomycin, cisdichlorodiammineplatinum (II) and mitomycin C. EBC-1 cells were incubated with the drug for one hour at 37°C or at elevated temperature (41°C, 42°C and 43°C). The enhancement of cytotoxicity by hyperthermia was found in combination with all of the drugs. The degree of enhanced cytotoxicity was positively elated to the temperature in combinations with adriamycin and bleomycin. Especially, a synergic enhancement of cytotoxicity was found with the combination of hyperthermia and bleomycin. The present study showed that the combination of hyperthermia and anticancer drugs produced potential cytotoxicity on EBC-1 cells in vitro, and may provide useful information for the clinical trials in the future.
en-copyright=
kn-copyright=

en-aut-name=SetoTakumi
en-aut-sei=Seto
en-aut-mei=Takumi
kn-aut-name=瀬戸匠
kn-aut-sei=瀬戸
kn-aut-mei=匠
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=human lung cancer cell line
kn-keyword=human lung cancer cell line
en-keyword=thermochemotherapy
kn-keyword=thermochemotherapy
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=5-6
article-no=
start-page=573
end-page=580
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of the treatment of pulmonary epidermoid carcinoma Part 1. Sensitivity to various anticancer drugs against human pulmonary epidermoid carcinoma xenograft in the hamster
kn-title=肺扁平上皮癌の治療に関する研究 第1編 ハムスター移植ヒト肺扁平上皮癌細胞株に対する各種制癌剤の感受性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Chemotherapy is the only therapeutic modality applicable to patients with advanced pulmonary epidermoid carcinoma (PEC). However, the results of chemotherapy to PEC remain unsatisfactory. It is very important to have an accurate knowledge of the sensitivity of anticancer drugs against PEC in order to establish a successful chemotherapy. The in vivo sensitivity of 12 anticancer drugs was investigated using PEC cell line (EBC-1) xenografts in hamsters.
In the present study, adriamycin, ifosphamide, mitomycin C, methotrexate and cisdichlorodiammineplatinum (II) showed antitumor activity against EBC-1 cells, but the other 6 drugs (ACNU, bleomycin, 5-fluorouracil, neocarzinostatin, procarbazine and vincristine) have no antitumor activity against EBC-1 cells. These results suggest that combination chemotherapy with 3 or 4 drugs with antitumor activity in the present study may be effective to PEC.
en-copyright=
kn-copyright=

en-aut-name=SetoTakumi
en-aut-sei=Seto
en-aut-mei=Takumi
kn-aut-name=瀬戸匠
kn-aut-sei=瀬戸
kn-aut-mei=匠
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=human lung cancer cell line
kn-keyword=human lung cancer cell line
en-keyword=xenograft
kn-keyword=xenograft
en-keyword=chemosensitivity test
kn-keyword=chemosensitivity test
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=5-6
article-no=
start-page=557
end-page=571
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Molecular cloning and structural analyses of human DNA sequences related to the squirrel monkey retrovirus LTR
kn-title=リスザルレトロウイルスLTR関連ヒト遺伝子の分子クローニングと構造解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Sequences related to the squirrel monkey retrovirus (SMRV) LTR were isolated from a genomic library of human DNA by screening under conditions of relaxed stringency. The probe contains several transcriptional signals and its regulatory sequences in SMRV-H LTR, such as the enhancer sequence, CAT box, TATA box, and polyadenylation signal. More than 50 positive signals were detected in 4.4×105 recombinant phages. The cloned human sequences named SRH strongly hybridized with SMRV-H LTR and some of them weakly hybridized with SMRV-H structural genes. In SRH-1, the region related to SMRV-H prt-pol-env was flanked by the two separately located sequences related to the LTR. SRH-3 has a solitary LTR-related region, whereas, in SRH-5, the LTR-related region was adjacent to the pol-env-related sequence. The reliability of these hybridization experiments was confirmed by reciprocal hybridization. The restriction enzyme cleavage maps of these clones were different from those of known human endogenous retroviruses. Alu sequences, a human highly repetitive sequences, were inserted to the LTR-and pol-env-related regions in SRH-5.
en-copyright=
kn-copyright=

en-aut-name=NagaoKazutaka
en-aut-sei=Nagao
en-aut-mei=Kazutaka
kn-aut-name=長尾一孝
kn-aut-sei=長尾
kn-aut-mei=一孝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌源研究施設生化学部門
en-keyword=ヒト内在性レトロウイルス
kn-keyword=ヒト内在性レトロウイルス
en-keyword=リスザルレトロウイルス
kn-keyword=リスザルレトロウイルス
en-keyword=Long terminal repeat
kn-keyword=Long terminal repeat
en-keyword=分子クローニング
kn-keyword=分子クローニング
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=5-6
article-no=
start-page=459
end-page=471
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunoelectron microscopic studies of human immunodeficiency virus antigens
kn-title=ヒト免疫不全ウイルス抗原の免疫電子顕微鏡的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Immunoelectron microscopic observations of human immunodeficiency virus (HIV) antigens were made using the indirect peroxidase-labeled antibody method with monoclonal antibodies (MoAb) to the envelope glycoprotein (gp160/120), matrix protein (MA, p17), and capsid protein (CA, p24). Antigens in the virions and HIV-infected cells were detected in frozen-sectioned specimens. Positive immunoreaction of MoAb to gp160/120 was located on the viral envelope, plasma membrane, endoplasmic reticulum, and nuclear membrane. The reaction of MoAb to p17 was at the inner leaflet of the viral envelope and the nucleoid. The reaction of MoAb to p24 was localized on and around the viral core. In cell suspension, however, positive immunostaining was observed only on the surface of the viral envelope and plasma membrane with MoAb to gp160/120, and no positive staining was observed with MoAb to p17 and MoAb to p24. The reaction of HIV-infected cells with normal control serum and all of the reactions in uninfected cells with these MoAbs were negative. It appears that antibodies have difficulty penetrating into virions and cells in cell suspension.
en-copyright=
kn-copyright=

en-aut-name=EndoSatoru
en-aut-sei=Endo
en-aut-mei=Satoru
kn-aut-name=遠藤悟
kn-aut-sei=遠藤
kn-aut-mei=悟
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌源研究施設生化学部門
en-keyword=ヒト免疫不全ウイルス
kn-keyword=ヒト免疫不全ウイルス
en-keyword=HIV抗原
kn-keyword=HIV抗原
en-keyword=構造蛋白質
kn-keyword=構造蛋白質
en-keyword=免疫電顕
kn-keyword=免疫電顕
en-keyword=酵素抗体法
kn-keyword=酵素抗体法
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=5-6
article-no=
start-page=423
end-page=435
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Detection of human sequence related to the squirrel monkey retrovirus
kn-title=ヒトゲノムDNA中のリスザルレトロウイルス関連遺伝子の検出
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Squirrel monkey retrovirus (SMRV) is an endogenous type D retrovirus of the squirrel monkey, a New World primate. Southern hybridization with cloned SMRV-H revealed that 3040 copies of SMRV proviral DNA are present in the squirrel monkey genome and the majority have almost the same physical map as that of the cloned SMRV-H. SMRV-related sequences in the human genome were sought using the same method with various cloned SMRV-H DNA fragments under conditions of relaxed stringency. The discrete restriction fragments were frequently detected in the DNA from normal humans with the LTR and parts of gag and env as probes. Since SMRV LTR has very little homology with the LTRs of other retroviruses, the fragments detected with the LTR probe were characterized as SMRV-related human sequences. SMRV LTR-related sequences were also detected in the African green monkey and chicken, but not in the salmon, mouse, or dog. In conclusion, SMRV-related sequences are present in human DNA, and some of them might represent endogenous retroviral sequences of human DNA.
en-copyright=
kn-copyright=

en-aut-name=AsonumaHirohiko
en-aut-sei=Asonuma
en-aut-mei=Hirohiko
kn-aut-name=阿曽沼裕彦
kn-aut-sei=阿曽沼
kn-aut-mei=裕彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌源研究施設生化学部門
en-keyword=ヒトDNA
kn-keyword=ヒトDNA
en-keyword=内在性レトロウイルス
kn-keyword=内在性レトロウイルス
en-keyword=リスザルレトロウイルス
kn-keyword=リスザルレトロウイルス
en-keyword=サザンハイブリダイゼーション
kn-keyword=サザンハイブリダイゼーション
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=3-4
article-no=
start-page=285
end-page=293
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Analysis of cellular oncogenes in human bone and soft tissue tumors
kn-title=ヒト骨・軟部腫瘍組織における癌遺伝子の解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The amplification and rearrangement of five cellular oncogenes (c-myc, c-K-ras, c-fos, c-raf-1, and N-myc) were studied by Southern hybridization in fourteen human bone and soft tissue tumors obtained at surgery. Amplification of c-myc was detected in the two of four osteosarcomas and one of two malignant fibrous histiocytomas. The c-myc genes in these tissues were amplified 4- to 8-fold in comparision with the placenta DNA. One of these osteosarcomas had 16- to 32-fold amplification of c-raf-1 gene without rearrangement. The clinical course of osteosarcoma and malignant fibrous histiocytoma with the amplified c-myc or c-raf-1 gene showed a rapid malignant progress with lung or bone metastasis. There appears to be a correlation between clinical prognosis and oncogene amplification.
en-copyright=
kn-copyright=

en-aut-name=SumiiHiroshi
en-aut-sei=Sumii
en-aut-mei=Hiroshi
kn-aut-name=住居広士
kn-aut-sei=住居
kn-aut-mei=広士
aut-affil-num=1
ORCID=

en-aut-name=InoueHajime
en-aut-sei=Inoue
en-aut-mei=Hajime
kn-aut-name=井上一
kn-aut-sei=井上
kn-aut-mei=一
aut-affil-num=2
ORCID=

en-aut-name=ItoShiro
en-aut-sei=Ito
en-aut-mei=Shiro
kn-aut-name=伊藤士郎
kn-aut-sei=伊藤
kn-aut-mei=士郎
aut-affil-num=3
ORCID=

en-aut-name=TanabeGozo
en-aut-sei=Tanabe
en-aut-mei=Gozo
kn-aut-name=田辺剛造
kn-aut-sei=田辺
kn-aut-mei=剛造
aut-affil-num=4
ORCID=

en-aut-name=TakechiHideo
en-aut-sei=Takechi
en-aut-mei=Hideo
kn-aut-name=武智秀夫
kn-aut-sei=武智
kn-aut-mei=秀夫
aut-affil-num=5
ORCID=

en-aut-name=IkedaShogo
en-aut-sei=Ikeda
en-aut-mei=Shogo
kn-aut-name=池田正五
kn-aut-sei=池田
kn-aut-mei=正五
aut-affil-num=6
ORCID=

en-aut-name=OdaTakuzo
en-aut-sei=Oda
en-aut-mei=Takuzo
kn-aut-name=小田琢三
kn-aut-sei=小田
kn-aut-mei=琢三
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部整形外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部整形外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部整形外科学教室

affil-num=5
en-affil=
kn-affil=吉備高原医療リハビリテーションセンター

affil-num=6
en-affil=
kn-affil=岡山大学医学部癌源研究施設生化学部門

affil-num=7
en-affil=
kn-affil=岡山大学医学部癌源研究施設生化学部門
en-keyword=Oncogene
kn-keyword=Oncogene
en-keyword=Gene amplification
kn-keyword=Gene amplification
en-keyword=c-myc
kn-keyword=c-myc
en-keyword=c-raf-1
kn-keyword=c-raf-1
en-keyword=Osteosarcoma
kn-keyword=Osteosarcoma
en-keyword=MFH
kn-keyword=MFH
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=1-2
article-no=
start-page=131
end-page=139
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Primary culture of human primary liver cancer tissues treated with or without transcatheter arterial embolization and establishment of a cell line
kn-title=肝動脈塞栓術施行或は非施行ヒト肝癌組織の初代培養と株化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Primary culture of human primary liver cancer tissues treated with or without trancatheter arterial embolization (TAE) was perfomed with the following results. 1. The yield and viability were very low in cells from primary liver cancer tissues dissociated with enzymes. 2. Epithelial-like cells were found from TAE-treated cancer tissues at a ratio of 1/8 in both monolayer and explant culture and from TAE-nontreated tissues at a ratio of 4/12 in monolayer culture and 3/12 in explant culture. The AFP-producing capahity of these epithelial-like cells has been maintained from one week to one month in culture. 3. Cells derived from two TAE-nontreated cancer tissues were subculturable. One was established as a cholangiocellular carcinoma cell line. 4. No heterotransplantability of primary cultured cancer cells into nude mice was found.
en-copyright=
kn-copyright=

en-aut-name=KusakaYasunori
en-aut-sei=Kusaka
en-aut-mei=Yasunori
kn-aut-name=日下泰徳
kn-aut-sei=日下
kn-aut-mei=泰徳
aut-affil-num=1
ORCID=

en-aut-name=TokiwaTakayoshi
en-aut-sei=Tokiwa
en-aut-mei=Takayoshi
kn-aut-name=常盤孝義
kn-aut-sei=常盤
kn-aut-mei=孝義
aut-affil-num=2
ORCID=

en-aut-name=SatoJiro
en-aut-sei=Sato
en-aut-mei=Jiro
kn-aut-name=佐藤二郎
kn-aut-sei=佐藤
kn-aut-mei=二郎
aut-affil-num=3
ORCID=

en-aut-name=TsugeHiroshi
en-aut-sei=Tsuge
en-aut-mei=Hiroshi
kn-aut-name=津下宏
kn-aut-sei=津下
kn-aut-mei=宏
aut-affil-num=4
ORCID=

en-aut-name=HamasakiKeisuke
en-aut-sei=Hamasaki
en-aut-mei=Keisuke
kn-aut-name=浜崎啓介
kn-aut-sei=浜崎
kn-aut-mei=啓介
aut-affil-num=5
ORCID=

en-aut-name=MimuraHisashi
en-aut-sei=Mimura
en-aut-mei=Hisashi
kn-aut-name=三村久
kn-aut-sei=三村
kn-aut-mei=久
aut-affil-num=6
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌源研究施設病理部門

affil-num=2
en-affil=
kn-affil=岡山大学医学部癌源研究施設病理部門

affil-num=3
en-affil=
kn-affil=岡山大学医学部癌源研究施設病理部門

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=TAE
kn-keyword=TAE
en-keyword=ヒト肝癌
kn-keyword=ヒト肝癌
en-keyword=初代培養
kn-keyword=初代培養
en-keyword=株化
kn-keyword=株化
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=1-2
article-no=
start-page=97
end-page=105
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunohistochemical studies on the binding of lectin (PNA) and human anti-liver cell membrane antibody to the hepatic carcinoma cell membrane of rats fed 3'-methyl-4-dimethylaminoazobenzene (DAB)
kn-title=ラットDAB肝癌の免疫組織学的研究―レクチンおよびヒト由来の肝細胞膜抗体の反応性について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Membrane changes of DAB hepatic carcinoma cells were examined immunohistochemically, using the binding activity of Arachis hypogaea agglutinin (PNA) and anti-liver membrane antibody (anti-LM) from patients with HBsAg-negative chronic active hepatitis. The hepatic carcinoma in rats was produced through DAB feedings for 3-5 months. As controls, non-cancerous liver tissues from rats fed DAB, and normal rat liver were used. In isolated calls of the hepatic carcinoma and control tissues, FITC-PNA binded in 10 of 11 cases of DAB hepatic carcinoma and in none of control cases (11 rats fed DAB and 2 normal rats). In tissue sections, similar results were obtained. Lens culnaris agglutinin did not show any difference in binding among the 3 groups. Two anti-LMs did not bind to the membranes of isolated calls in 3 of 10 DAB hepatic carcinomas, although the anti-LMs were bound in all of controls. These facts indicate that the transformation, DAB hepatic carcinoma cells is accompanied by changes in the cell membrane, and that PNA may be useful in the analysis of membrane changes in carcinogenesis.
en-copyright=
kn-copyright=

en-aut-name=TomidaOsamu
en-aut-sei=Tomida
en-aut-mei=Osamu
kn-aut-name=冨田治
kn-aut-sei=冨田
kn-aut-mei=治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
en-keyword=DAB肝癌
kn-keyword=DAB肝癌
en-keyword=PNA
kn-keyword=PNA
en-keyword=肝細胞膜抗体免疫蛍光法
kn-keyword=肝細胞膜抗体免疫蛍光法
en-keyword=レクチン蛍光法
kn-keyword=レクチン蛍光法
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=11-12
article-no=
start-page=1287
end-page=1297
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Chemosensitivity test using subrenal capsule assays Part 1. Experimental evaluation
kn-title=Subrenal capsule assay法による制癌剤感受性試験に関する研究 第1編 Subrenal capsule assay法の基礎的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Experimental evaluation of a new chemosensitivity test using a subrenal capsule assays (SRC) was performed. The effects of various immunosuppressants-cyclosporin A (CSA), cyclophosphamide, whole body irradiation, and Bredinin were studied using human small cell lung cancer cell line (SBC-3) serially transplanted in nude mice. A significant degree of host cell infiltration was seen in tumor fragments implanted under the renal capsule of immunocompetent mice. However, treatment with immunosuppressants effectively suppressed the host immune reaction. The most effective immunosuppressant was CSA at 60mg/kg. We compared the antitumor activities of CDDP, MMC, VP-16, ADM, CPA, and VCR against SBC-3 using SRC and clonogenic assays. SRC was performed using mice administered CSA 60mg/kg. Chemotherapeutic agents (1/2 LD(10)) were administered on day 1 and antitumor activities were evaluated on day 6 after implantation. The results of the assays were well-correlated except with VCR.
en-copyright=
kn-copyright=

en-aut-name=TadaAtsuhiko
en-aut-sei=Tada
en-aut-mei=Atsuhiko
kn-aut-name=多田敦彦
kn-aut-sei=多田
kn-aut-mei=敦彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Subrenal capsule assay法
kn-keyword=Subrenal capsule assay法
en-keyword=制癌剤感受性試験
kn-keyword=制癌剤感受性試験
en-keyword=ヒト肺小細胞癌株
kn-keyword=ヒト肺小細胞癌株
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=11-12
article-no=
start-page=1267
end-page=1273
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A human monoclonal antibody against Pseudomonas aeruginosa and the possibility of its clinical use
kn-title=緑膿菌に対するヒト型モノクローナル抗体の作成とその臨床応用の可能性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A human monoclonal antibody (IgG) against Pseudomonas aeruginosa was established within 3 weeks after fusion of patient lymphocytes and human myeloma WIL2-86 cells. This method is useful in establishing human monoclonal antibodies for infectious bacteria of a variety of antigenicities and allows for use of such antibodies as immunotherapeutic drugs in chronically infected patients. The opsonic effect of the monoclonal antibody we established was 1.8-fold higher than that of commercially available immunoglobulin drugs. Since the established human monoclonal antibody recognizes serotype M, which has not yet been produced, the antibody may be used as a part of immunotherapeutic drug “cocktail”.
en-copyright=
kn-copyright=

en-aut-name=KobayashiYouji
en-aut-sei=Kobayashi
en-aut-mei=Youji
kn-aut-name=小林洋二
kn-aut-sei=小林
kn-aut-mei=洋二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=ヒト型モノクローナル抗体
kn-keyword=ヒト型モノクローナル抗体
en-keyword=緑膿菌
kn-keyword=緑膿菌
en-keyword=M型O抗原
kn-keyword=M型O抗原
en-keyword=オプソニン
kn-keyword=オプソニン
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=9-10
article-no=
start-page=1119
end-page=1126
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199010
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the reactivity of human basophilic leukocytes Part 1. Correlation between morphological changes of human basophilic leukocytes and histamine release after stimulation with antigen or anti-IgE
kn-title=好塩基球の反応性に関する研究 第1編 抗原，抗ヒトIgE刺激時の好塩基球の経時的形態的変化とヒスタミン遊離
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Morphological changes in human basophils from atopic asthmatics were observed in whole blood smears with respect to histamine release after stimulation with antigen or anti-IgE. Histamine was rapidly released and was accompanied by morphological changes in basophils upon stimulation with antigen and anti-IgE. A decreased number of basophils and morphological changes including increased cell diameters, increased ratios of the short to long axis diameters, and decreased intracellular granule counts were observed upon the release of histamine after antigen and anti-IgE stimulation. Antigen stimulus induced both more rapid histamine release and morphological changes than anti-IgE stimulation.
en-copyright=
kn-copyright=

en-aut-name=NakagawaSaburo
en-aut-sei=Nakagawa
en-aut-mei=Saburo
kn-aut-name=中川三郎
kn-aut-sei=中川
kn-aut-mei=三郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=気管支喘息
kn-keyword=気管支喘息
en-keyword=好塩基球
kn-keyword=好塩基球
en-keyword=形態的変化
kn-keyword=形態的変化
en-keyword=特異抗原
kn-keyword=特異抗原
en-keyword=抗ヒトIgE
kn-keyword=抗ヒトIgE
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=9-10
article-no=
start-page=1061
end-page=1074
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199010
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An immunohistochemical study of the localization of α and β subunits of S-100 protein in normal human brains and brain tumors
kn-title=ヒト正常脳および脳腫瘍におけるS-100蛋白サブユニット(α鎖，β鎖)の局在に関する免疫組織化学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Immunohistochemical localization of α and β subunits of the S-100 protein in normal human brains and brain tumors was studied by the ABC method using mouse monoclonal antibodies against each subunit. In cerebral tissues, glial cells showed positive staining for both subunits, with some neurons positive only for the α subunit.
In cerebellum, Purkinje cells and other neurons were negative for the α or β subunit, and Bergmann's cells were positive only for the β subunit. Low grade astrocytomas were strongly positive for the α and β subunits. In oligodendrogliomas and choroid plexus papillomas, the immunoreactivity of the β subunit was stronger than that of the α subunit. Medulloblastomas showed no positive staining for either subunit. Schwannomas were positive only for the β subunit. High grade astrocytomas, ependymomas and meningiomas manifested marked variability in the immunoreactivity for the α and β subunits of the S-100 protein. The evidence suggests that immunohistochemical examination of the α and β subunits of the S-100 protein in normal human brains and brain tumors may be useful in determining the histogenetic origin of brain tumors.
en-copyright=
kn-copyright=

en-aut-name=TamiyaTakashi
en-aut-sei=Tamiya
en-aut-mei=Takashi
kn-aut-name=田宮隆
kn-aut-sei=田宮
kn-aut-mei=隆
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科学教室
en-keyword=S-100蛋白α鎖サブユニット
kn-keyword=S-100蛋白α鎖サブユニット
en-keyword=S-100蛋白β鎖サブユニット
kn-keyword=S-100蛋白β鎖サブユニット
en-keyword=ヒト正常脳
kn-keyword=ヒト正常脳
en-keyword=ヒト脳腫瘍
kn-keyword=ヒト脳腫瘍
en-keyword=免疫組織化学
kn-keyword=免疫組織化学
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=5-6
article-no=
start-page=593
end-page=601
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Establishment of a new cell line derived from hepatocellular carcinoma exhibiting non-epithelial morphology
kn-title=非上皮細胞様形態を呈するヒト肝細胞癌由来細胞株の樹立
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A cell line, HuH-33, was established in vitro from a patient with hepatocellular carcinoma (HCC), who had been treated with some chemotherapeutic agents. The chromosome number was widely distributed in 6888. This cell line has grown slowly, exhibiting a doubling time of approximately 150h, was intransplantable into nude mice, and secreted alpha-fetoprotein, albumin, β2-microglobulin, ferritin, tissue peptide antigen and extracellular matrix materials. HuH-33 was polygonal or spindle shaped, but it was keratin-positive and desmosome-like structures were observed with transmission electron microscopy, suggesting an epithelial origin of HuH-33.
en-copyright=
kn-copyright=

en-aut-name=EndoAkira
en-aut-sei=Endo
en-aut-mei=Akira
kn-aut-name=遠藤彰
kn-aut-sei=遠藤
kn-aut-mei=彰
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌源研究施設病理部門
en-keyword=Hepatoma cell line
kn-keyword=Hepatoma cell line
en-keyword=cytokeratin
kn-keyword=cytokeratin
en-keyword=non-epithelial
kn-keyword=non-epithelial
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=3-4
article-no=
start-page=357
end-page=364
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An immunohistochemical and clinical study of human growth hormone in lung cancer
kn-title=肺癌組織内ヒト成長ホルモンの免疫組織学的および臨床的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The human growth hormone (hGH) in lung cancer was studied immunohistochemically in 160 patients by the PAP method. Thirty-four neoplasm specimens (21.3%) contained hGH-positive tumor cells. Positive reaction for hGH was shown in 19 of 64 squamous cell carcinomas, 13 of 48 adenocarcinomas, 2 of 5 carcinods, and none of 26 small cell carcinomas and 17 large cell carcinomas. The sensitivity for hilar type lung cancer was higher than that for peripheral type (p<0.05). Positive rates for hGH were not affected by age, sex, tumor size, lymph node involvement or postsurgical stage. The survival rate of hGH positive patients was not worse than that of hGH negative.
en-copyright=
kn-copyright=

en-aut-name=KunikataEiji
en-aut-sei=Kunikata
en-aut-mei=Eiji
kn-aut-name=國方永治
kn-aut-sei=國方
kn-aut-mei=永治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=肺癌
kn-keyword=肺癌
en-keyword=ヒト成長ホルモン
kn-keyword=ヒト成長ホルモン
en-keyword=酵素抗体法
kn-keyword=酵素抗体法
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=医療用組換えヒトエリスロポエチンの品質および生物学的活性の管理
kn-title=Quality control and biological potency management of therapeutic recombinant human erythropoietin
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YanagiharaShigehiro
en-aut-sei=Yanagihara
en-aut-mei=Shigehiro
kn-aut-name=柳原繁弘
kn-aut-sei=柳原
kn-aut-mei=繁弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト口腔細菌叢の健康時と病的時の変移に関する研究
kn-title=Analysis of Human Oral Bacterial Communities in Health and Disease
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WaelAmgad Refaat Ahmed Hassan
en-aut-sei=Wael
en-aut-mei=Amgad Refaat Ahmed Hassan
kn-aut-name=ワエルアムカドレファット アハマド ハッサン
kn-aut-sei=ワエル
kn-aut-mei=アムカドレファット アハマド ハッサン
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=最終糖化産物はヒト混合リンパ球反応において単球機能の活性化を増強する
kn-title=Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OhashiKatsuhisa
en-aut-sei=Ohashi
en-aut-mei=Katsuhisa
kn-aut-name=大橋勝久
kn-aut-sei=大橋
kn-aut-mei=勝久
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト血中生存浮遊がん細胞の簡易イメージングシステム
kn-title=A simple biological imaging system for detecting viable human circulating tumor cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KojimaToru
en-aut-sei=Kojima
en-aut-mei=Toru
kn-aut-name=児島亨
kn-aut-sei=児島
kn-aut-mei=亨
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=53
cd-vols=
no-issue=
article-no=
start-page=29
end-page=33
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=19830325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=好塩基球からのヒスタミン遊離に関する研究. 2. ハウスダスト抗原および抗ヒトIgEによるヒスタミン遊離
kn-title=Studies on the release of histamine from basophils 2. Histamine release induced by house dust extract and anti-IgE
en-subtitle=
kn-subtitle=
en-abstract=好塩基球からのIgE-mediated histamine releaseの機序を,健康人(2名)および気管支喘息(4例)それぞれの代表例で比較検討した. 抗ヒトIgEの添加濃度別検討では,健康人および外因性喘息例いずれも有意のヒスタミン遊離の増加をしめしたが,Max. % histamine releaseをひきおこす抗ヒトIgEの濃度は比較的限られた範囲内にある傾向がみられた. 一方内因性喘息例では,いずれの抗ヒトIgE濃度でも有意のヒスタミン遊離はみられなかった. ハウスダスト抗原の添加濃度別検討では,ハウスダストが抗原である気管支喘息症例においてdose-dependentなヒスタミン遊離が観察されたが,使用された抗原濃度の範囲ではMax. % releaseをひきおこす至適濃度は明らかでなかった.
kn-abstract=IgE-mediated release of histamine from whole blood was examined in two healthy and four asthmatic subjects by dose-dependent fashion. The significantly increased amount of histamine was released from basophils of both healthy and asthmatic subjects by a limited concentration of anti-IgE. Antigen (house dust) caused histamine release only from basophils of asthmatics who are sensitive to house dust. Basophils from one patients with asthma released no significant amount of histamine by anti-IgE.
en-copyright=
kn-copyright=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

en-aut-name=KomagoeHaruki
en-aut-sei=Komagoe
en-aut-mei=Haruki
kn-aut-name=駒越春樹
kn-aut-sei=駒越
kn-aut-mei=春樹
aut-affil-num=2
ORCID=

en-aut-name=SudoMichiyasu
en-aut-sei=Sudo
en-aut-mei=Michiyasu
kn-aut-name=周藤真康
kn-aut-sei=周藤
kn-aut-mei=真康
aut-affil-num=3
ORCID=

en-aut-name=MifuneMasaaki
en-aut-sei=Mifune
en-aut-mei=Masaaki
kn-aut-name=御般政明
kn-aut-sei=御般
kn-aut-mei=政明
aut-affil-num=4
ORCID=

en-aut-name=MorinagaHiroshi
en-aut-sei=Morinaga
en-aut-mei=Hiroshi
kn-aut-name=森永寛
kn-aut-sei=森永
kn-aut-mei=寛
aut-affil-num=5
ORCID=

en-aut-name=KitaniHikaru
en-aut-sei=Kitani
en-aut-mei=Hikaru
kn-aut-name=貴谷光
kn-aut-sei=貴谷
kn-aut-mei=光
aut-affil-num=6
ORCID=

en-aut-name=GodaYoshinori
en-aut-sei=Goda
en-aut-mei=Yoshinori
kn-aut-name=合田吉徳
kn-aut-sei=合田
kn-aut-mei=吉徳
aut-affil-num=7
ORCID=

en-aut-name=TadaShinya
en-aut-sei=Tada
en-aut-mei=Shinya
kn-aut-name=多田慎也
kn-aut-sei=多田
kn-aut-mei=慎也
aut-affil-num=8
ORCID=

en-aut-name=KimuraIkuro
en-aut-sei=Kimura
en-aut-mei=Ikuro
kn-aut-name=木村郁郎
kn-aut-sei=木村
kn-aut-mei=郁郎
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=2
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=5
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=6
en-affil=
kn-affil=岡山大学医学部附属病院第2内科

affil-num=7
en-affil=
kn-affil=岡山大学医学部附属病院第2内科

affil-num=8
en-affil=
kn-affil=岡山大学医学部附属病院第2内科

affil-num=9
en-affil=
kn-affil=岡山大学医学部附属病院第2内科
END

start-ver=1.4
cd-journal=joma
no-vol=53
cd-vols=
no-issue=
article-no=
start-page=23
end-page=28
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=19830325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=好塩基球からのヒスタミン遊離に関する研究. 1 自動分析装置による全血からのヒスタミン遊離の測定
kn-title=Studies on the release of histamine from basophils 1. Determination of histamine from whole blood by an automated fluorometric histamine analysis system
en-subtitle=
kn-subtitle=
en-abstract=ヒスタミン自動分析装置により,健康人10名,気管支喘息23例の全血からのヒスタミン遊離を測定した. 抗ヒトIgEを添加した際のヒスタミン遊離は,健康人および外因性気管支喘息症例では有意の増加傾向を示したが,一方内因性喘息症例では遊離増加はほとんどみられなかった. ハウスダスト抗原添加では,ハウスダストが抗原である気管支喘息症例においてのみ全血からの有意のヒスタミン遊離の増加が観察された. 以上の結果より,ヒスタミン自動分析装置による全血からの遊離ヒスタミンの測定は,気管支喘息の病態解明の1手段として極めて有用であると考えられる.
kn-abstract=Histamine released from whole blood was determined by an automated fiuorometric histamine analysis system. The increased release of histamine from basophils by anti-IgE was observed in ten healthy subjects and 12 extrinsic asthma patients, while the release in 11 intrinsic asthma patients was significantly less as compared to that in healthy and extrinsic asthma subjects. House dust extract caused a significant increase in the histamine release from basophils of the extrinsic asthma patients who are sensitive to house dust. It was concluded from this study that histamine released from basophils could be easily determined by an automated analysis system and that the
method is useful for the diagnosis and study of allergy.
en-copyright=
kn-copyright=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

en-aut-name=KomagoeHaruki
en-aut-sei=Komagoe
en-aut-mei=Haruki
kn-aut-name=駒越春樹
kn-aut-sei=駒越
kn-aut-mei=春樹
aut-affil-num=2
ORCID=

en-aut-name=SudoMichiyasu
en-aut-sei=Sudo
en-aut-mei=Michiyasu
kn-aut-name=周藤真康
kn-aut-sei=周藤
kn-aut-mei=真康
aut-affil-num=3
ORCID=

en-aut-name=MifuneMasaaki
en-aut-sei=Mifune
en-aut-mei=Masaaki
kn-aut-name=御般政明
kn-aut-sei=御般
kn-aut-mei=政明
aut-affil-num=4
ORCID=

en-aut-name=MorinagaHiroshi
en-aut-sei=Morinaga
en-aut-mei=Hiroshi
kn-aut-name=森永寛
kn-aut-sei=森永
kn-aut-mei=寛
aut-affil-num=5
ORCID=

en-aut-name=OhtaniJun
en-aut-sei=Ohtani
en-aut-mei=Jun
kn-aut-name=大谷純
kn-aut-sei=大谷
kn-aut-mei=純
aut-affil-num=6
ORCID=

en-aut-name=KitaniHikaru
en-aut-sei=Kitani
en-aut-mei=Hikaru
kn-aut-name=貴谷光
kn-aut-sei=貴谷
kn-aut-mei=光
aut-affil-num=7
ORCID=

en-aut-name=GodaYoshinori
en-aut-sei=Goda
en-aut-mei=Yoshinori
kn-aut-name=合田吉徳
kn-aut-sei=合田
kn-aut-mei=吉徳
aut-affil-num=8
ORCID=

en-aut-name=TadaShinya
en-aut-sei=Tada
en-aut-mei=Shinya
kn-aut-name=多田慎也
kn-aut-sei=多田
kn-aut-mei=慎也
aut-affil-num=9
ORCID=

en-aut-name=KimuraIkuro
en-aut-sei=Kimura
en-aut-mei=Ikuro
kn-aut-name=木村郁郎
kn-aut-sei=木村
kn-aut-mei=郁郎
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=2
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=5
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=6
en-affil=
kn-affil=岡山大学医学部附属病院第2内科

affil-num=7
en-affil=
kn-affil=岡山大学医学部附属病院第2内科

affil-num=8
en-affil=
kn-affil=岡山大学医学部附属病院第2内科

affil-num=9
en-affil=
kn-affil=岡山大学医学部附属病院第2内科

affil-num=10
en-affil=
kn-affil=岡山大学医学部附属病院第2内科
END

start-ver=1.4
cd-journal=joma
no-vol=54
cd-vols=
no-issue=
article-no=
start-page=35
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19840325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=好塩基球からのヒスタミン遊離に関する研究. 3. 抗ヒトIgE に対する好塩基球の反応性と末梢血好酸球増多
kn-title=Studies on the release of histamine from basophils. 3. Correlation between basophil reactivity to anti-IgE and blood eosinophilia
en-subtitle=
kn-subtitle=
en-abstract=末梢血好酸球増多を示す気管支喘息14症例について,抗ヒトIgE による好塩基球からのヒスタミン遊離を検討した. ハウスダストに対する皮内反応およびRASTが陽性を示す症例群(groupI)では,血清IgE値が高く,また抗ヒトIgEによるMax. % ヒスタミン遊離も高く(50.7士5.0%),そのdoseresponse curveは抗ヒトIgE添加濃度が高くなるにつれて上昇する傾向を示した.一方種々のアレルゲンエキスに対する皮内反応が陰性で,かつRAST も陰性を示す症例群(group II)では,血清IgE値が低く,また抗ヒトIgEによるMax. % ヒスタミン遊離も低く(10.5士1.7%),そのdose-response curveは全般的に低く,抗ヒトIgE添加濃度が高いところではむしろ抑制される傾向を示した.
kn-abstract=Histamine release from basophils induced by anti-IgE was examined in 14 asthmatic subjects with blood eosinophilia. The subjects were divided into two groups; group I (with blood eosinophilia, positive skin test and positive RAST to house dust) and group II (with blood eosinophilia, negative skin test to various allergens and negative RAST to house dust). 1. Serum IgE levels in group I were much higher than those in group II. 2. Maximum percent histamine release induced by anti-IgE was much higher in group I than in group II. 3. Dose-response curve of anti-IgE-induced histamine release in group I showed consistent increase as anti-IgE concentrations increased. while, dose-response curve in group II was very low. These findings suggested that blood eosinophilia in group I might be elicited relating to IgE-mediated reaction. However, mechanism causing eosinophilia in group II was not clear in the present study.
en-copyright=
kn-copyright=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

en-aut-name=KomagoeHaruki
en-aut-sei=Komagoe
en-aut-mei=Haruki
kn-aut-name=駒越春樹
kn-aut-sei=駒越
kn-aut-mei=春樹
aut-affil-num=2
ORCID=

en-aut-name=SudoMichiyasu
en-aut-sei=Sudo
en-aut-mei=Michiyasu
kn-aut-name=周藤真康
kn-aut-sei=周藤
kn-aut-mei=真康
aut-affil-num=3
ORCID=

en-aut-name=MifuneMasaaki
en-aut-sei=Mifune
en-aut-mei=Masaaki
kn-aut-name=御般政明
kn-aut-sei=御般
kn-aut-mei=政明
aut-affil-num=4
ORCID=

en-aut-name=MorinagaHiroshi
en-aut-sei=Morinaga
en-aut-mei=Hiroshi
kn-aut-name=森永寛
kn-aut-sei=森永
kn-aut-mei=寛
aut-affil-num=5
ORCID=

en-aut-name=NakagawaSaburo
en-aut-sei=Nakagawa
en-aut-mei=Saburo
kn-aut-name=中川三郎
kn-aut-sei=中川
kn-aut-mei=三郎
aut-affil-num=6
ORCID=

en-aut-name=KitaniHikaru
en-aut-sei=Kitani
en-aut-mei=Hikaru
kn-aut-name=貴谷光
kn-aut-sei=貴谷
kn-aut-mei=光
aut-affil-num=7
ORCID=

en-aut-name=KimuraIkuro
en-aut-sei=Kimura
en-aut-mei=Ikuro
kn-aut-name=木村郁郎
kn-aut-sei=木村
kn-aut-mei=郁郎
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=2
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=5
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=6
en-affil=
kn-affil=岡山大学医学部第2内科

affil-num=7
en-affil=
kn-affil=岡山大学医学部第2内科

affil-num=8
en-affil=
kn-affil=岡山大学医学部第2内科
END

start-ver=1.4
cd-journal=joma
no-vol=55
cd-vols=
no-issue=
article-no=
start-page=7
end-page=10
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19841130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Spa therapy for patients with chronic obstructive lung disease
kn-title=Studies on the release of histamine from basophils 4. Difference between house dust- and Candida-induced secretion
en-subtitle=
kn-subtitle=
en-abstract=ハウスダストあるいはカンジダが特異抗原である気管支喘息30例を対象に,それぞれの抗原刺激時の好塩基球からのヒスタミン遊離を,抗ヒトIgEによる遊離と比較検討した. 1. ハウスダストが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時41.8%,抗ヒトIgE刺激時40.8%であった. 2. カンジダが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時27.1%,抗ヒトIgE刺激時32.2%であった. 3. ハウスダストと抗ヒトIgEによる好塩基球からのヒスタミン遊離は,ほぼ同様の値を示した. 一方カンジダと抗ヒトIgEによるヒスタミン遊離の間には有意の
相関関係はみられなかった.
kn-abstract=Histamine releasse from basophils induced by house dust and C. albicans was examined in 30 patients with bronchial asthma. House dust and C. albicans caused a significant amount of histamine release in subjects with a RAST score to corresponding allergen. A close correlation was found between house dust- and anti-IgE-induced histamine release. However, histamine release induced by C. albicans was considerably different from the release induced by anti-IgE.
en-copyright=
kn-copyright=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

en-aut-name=KomagoeHaruki
en-aut-sei=Komagoe
en-aut-mei=Haruki
kn-aut-name=駒越春樹
kn-aut-sei=駒越
kn-aut-mei=春樹
aut-affil-num=2
ORCID=

en-aut-name=SudoMichiyasu
en-aut-sei=Sudo
en-aut-mei=Michiyasu
kn-aut-name=周藤真康
kn-aut-sei=周藤
kn-aut-mei=真康
aut-affil-num=3
ORCID=

en-aut-name=MorinagaHiroshi
en-aut-sei=Morinaga
en-aut-mei=Hiroshi
kn-aut-name=森永寛
kn-aut-sei=森永
kn-aut-mei=寛
aut-affil-num=4
ORCID=

en-aut-name=KitaniHikaru
en-aut-sei=Kitani
en-aut-mei=Hikaru
kn-aut-name=貴谷光
kn-aut-sei=貴谷
kn-aut-mei=光
aut-affil-num=5
ORCID=

en-aut-name=NakagawaSaburo
en-aut-sei=Nakagawa
en-aut-mei=Saburo
kn-aut-name=中川三郎
kn-aut-sei=中川
kn-aut-mei=三郎
aut-affil-num=6
ORCID=

en-aut-name=KimuraIkuro
en-aut-sei=Kimura
en-aut-mei=Ikuro
kn-aut-name=木村郁郎
kn-aut-sei=木村
kn-aut-mei=郁郎
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=2
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=5
en-affil=
kn-affil=岡山大学第2内科

affil-num=6
en-affil=
kn-affil=岡山大学第2内科

affil-num=7
en-affil=
kn-affil=岡山大学第2内科
END

start-ver=1.4
cd-journal=joma
no-vol=56
cd-vols=
no-issue=
article-no=
start-page=17
end-page=21
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19850330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=好塩基球からのヒスタミン遊離に関する研究. 5.臨床的評価
kn-title=Studies on the release of histamine from basophils 5. Clinical evaluation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=過去3年間にわたり,気管支喘息患者末梢血好塩基球からのヒスタミン遊離について,ヒスタミン自動分析装置を用いて全血法により検討を加えてきた. 1. 抗ヒトIgE によるヒスタミン遊離は,症例間で著しい差がみられた. この際血清IgE値が高値を示す症例では全般的に高度なヒスタシソ遊離がみられたが,血清IgE値が正常かまたはむしろ低値を示す症例のヒスタミン遊離は,かなり高度なものから全くみられないものまでさまざまであった. 2.ハウスダストやカンジダなどの抗原物質によるヒスタミン遊離は,特異的IgE抗体依存性であり,抗体価が上昇するにつれヒスタミン遊離は高度となる傾向がみられた. しかし,ハウスダストとカンジダによるヒスタミン遊離には若干の差がみられた. すなわち,ハウスダストと抗ヒトIgE によるヒスタミン遊離の間には密接な関連がみられたが,カンジダと抗ヒトIgEの間には全く関連がみられなかった. またカンジダによるヒスタミン遊離においては,IgE系反応以外の反応が関与する可能性が一部示唆された.
en-copyright=
kn-copyright=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

en-aut-name=KomagoeHaruki
en-aut-sei=Komagoe
en-aut-mei=Haruki
kn-aut-name=駒越春樹
kn-aut-sei=駒越
kn-aut-mei=春樹
aut-affil-num=2
ORCID=

en-aut-name=SudoMichiyasu
en-aut-sei=Sudo
en-aut-mei=Michiyasu
kn-aut-name=周藤真康
kn-aut-sei=周藤
kn-aut-mei=真康
aut-affil-num=3
ORCID=

en-aut-name=MorinagaHiroshi
en-aut-sei=Morinaga
en-aut-mei=Hiroshi
kn-aut-name=森永寛
kn-aut-sei=森永
kn-aut-mei=寛
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=2
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学三朝分院内科
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=2
end-page=4
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=環境の発ガン物質に対するヒト曝露の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HayatsuHikoya
en-aut-sei=Hayatsu
en-aut-mei=Hikoya
kn-aut-name=早津彦哉
kn-aut-sei=早津
kn-aut-mei=彦哉
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学薬学部
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=
article-no=
start-page=12
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=199809
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=癌の遺伝子治療
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=癌抑制遺伝子p53の突然変異や欠損による機能的異常は､多くのヒト癌で普遍的かつ高頻度に認められている｡p53タンパク質の機能の一つとしては､細胞増殖に関するいろいろな遺伝子の発現制御を介した細胞周期の調節が考えられているが､その他に最近アポトーシスの誘導分子としても注目を浴びてきている｡正常型p53遺伝子を有する胃癌､大腸癌では､術前化学療法や放射線療法で癌細胞のアポトーシスが誘導されたが､変異型p53を発現する腫瘍
ではアポトーシスに陥った細胞はほとんど認められなかった｡ヌードマウスの皮下に移植したp53遺伝子に異常を持つヒト肺癌腫瘍にリコンビナント･アデノウイルスベクターを用いて正常型p53遺伝子を導入すると､抗癌剤に対する感受性が劇的に増強し､シスプラチンの腹腔内投与により腫瘍内にアポトーシスによる広範囲な組織破壊が認められた｡この正常型p53発現アデノウイルスベクターとDNA障害性抗癌剤を併用した遺伝子治療は､臨床的にヒト悪性腫癌に応用可能と考えられる｡
en-copyright=
kn-copyright=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=
article-no=
start-page=35
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=200409
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of High-Fat and High-Calorie Diets on the Onset of Diabetes in Meg1/Grb10 Transgenic Mice
kn-title=高脂肪･高カロリー飼料がMeg1/Grb10遺伝子導入マウスの糖尿病発症に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Meg1/Grb10遺伝子導入マウスはインスリンのシグナル伝達阻害による高インスリン血症を呈することから､II型糖尿病モデルと考えられている｡そこで､本モデルマウスを用いてII型糖尿病発症に及ぼす飼料の影響について検討した結果､ヒトII型糖尿病モデルとして有用性を確認することが出来た｡
en-copyright=
kn-copyright=

en-aut-name=YamamotoYoshie
en-aut-sei=Yamamoto
en-aut-mei=Yoshie
kn-aut-name=山本美江
kn-aut-sei=山本
kn-aut-mei=美江
aut-affil-num=1
ORCID=

en-aut-name=SuzukiOsamu
en-aut-sei=Suzuki
en-aut-mei=Osamu
kn-aut-name=鈴木治
kn-aut-sei=鈴木
kn-aut-mei=治
aut-affil-num=2
ORCID=

en-aut-name=Yamada-UchioKozue
en-aut-sei=Yamada-Uchio
en-aut-mei=Kozue
kn-aut-name=山田‐内尾こずえ
kn-aut-sei=山田‐内尾
kn-aut-mei=こずえ
aut-affil-num=3
ORCID=

en-aut-name=Ishino-KanekoTomoko
en-aut-sei=Ishino-Kaneko
en-aut-mei=Tomoko
kn-aut-name=石野‐金児智子
kn-aut-sei=石野‐金児
kn-aut-mei=智子
aut-affil-num=4
ORCID=

en-aut-name=MatsudaJunichirou
en-aut-sei=Matsuda
en-aut-mei=Junichirou
kn-aut-name=松田潤一郎
kn-aut-sei=松田
kn-aut-mei=潤一郎
aut-affil-num=5
ORCID=

en-aut-name=SatoKatsunori
en-aut-sei=Sato
en-aut-mei=Katsunori
kn-aut-name=佐藤勝紀
kn-aut-sei=佐藤
kn-aut-mei=勝紀
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=2
en-affil=
kn-affil=国立感染症研究所獣医科学部

affil-num=3
en-affil=
kn-affil=国立感染症研究所獣医科学部

affil-num=4
en-affil=
kn-affil=東海大学健康科学部

affil-num=5
en-affil=
kn-affil=国立感染症研究所獣医科学部

affil-num=6
en-affil=
kn-affil=岡山大学農学部
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=19
end-page=21
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=200712
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study on the usefulness of Meg1Crb10 transgenic mouse as aType2 diabetes mellitus model animal. -Analysis of blood plasma component and expression of genes related to onset of diabetes -
kn-title=2型糖尿病モデル動物Meg1/Grb10遺伝子導入マウスの有用性の検討 - 血漿成分及び糖尿病関連遺伝子の発現と発症の解析 -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Meg1/Grb10遺伝子導入マウス（Meg1マウス）はインスリンのシグナル伝達阻害による高インスリン血症を呈することから2型糖尿病モデルと考えられている。Meg1マウスは肥満を伴なわずに高血糖を発症するが､脂肪･カロリーの過剰摂取によっても糖尿病の発症が著しく増加する｡本研究はMeg1マウスの2型糖尿病モデルとしての有用性を検討するために､Meg1マウスと対照マウスを高脂肪･高カロリー飼料（HFD）及び対照飼料（NFD）で飼育した時の血漿アディポネクチン量とBMI値を比較するとともに糖尿病関連遺伝子の発現量について他の糖尿病モデルマウスと比較検討した。血漿アディポネクチン量はMeg1マウスのHFDが最も高く､対照マウスのNFDが最も低い値を示した。一方､BMI値は対照マウスのHFDが最も高い値を示し､血漿アディポネクチン量とBMI値は逆相関が認められ､ヒト2型糖尿病と類似することが認められた。また､Grb10､Glut4遺伝子の発現量はMeg1マウスと他の糖尿病モデルマウスでは異なる値を示し､Meg1マウスでのGrb10遺伝子の発現量は高く､Glut4遺伝子の発現量は低かった。以上のことから､Meg1マウスには他の糖尿病モデルと異なる発症機構の存在が示唆され､Meg1マウスは2型糖尿病モデルとしての有用性が考えられた。
en-copyright=
kn-copyright=

en-aut-name=YamamotoYoshie
en-aut-sei=Yamamoto
en-aut-mei=Yoshie
kn-aut-name=山本美江
kn-aut-sei=山本
kn-aut-mei=美江
aut-affil-num=1
ORCID=

en-aut-name=SuzukiOsamu
en-aut-sei=Suzuki
en-aut-mei=Osamu
kn-aut-name=鈴木治
kn-aut-sei=鈴木
kn-aut-mei=治
aut-affil-num=2
ORCID=

en-aut-name=Yamada-UchioKozue
en-aut-sei=Yamada-Uchio
en-aut-mei=Kozue
kn-aut-name=山田-内尾こずえ
kn-aut-sei=山田-内尾
kn-aut-mei=こずえ
aut-affil-num=3
ORCID=

en-aut-name=Ishino-KanekoTomoko
en-aut-sei=Ishino-Kaneko
en-aut-mei=Tomoko
kn-aut-name=石野-金児智子
kn-aut-sei=石野-金児
kn-aut-mei=智子
aut-affil-num=4
ORCID=

en-aut-name=MatsudaJunichirou
en-aut-sei=Matsuda
en-aut-mei=Junichirou
kn-aut-name=松田潤一郎
kn-aut-sei=松田
kn-aut-mei=潤一郎
aut-affil-num=5
ORCID=

en-aut-name=SatoKatsunori
en-aut-sei=Sato
en-aut-mei=Katsunori
kn-aut-name=佐藤勝紀
kn-aut-sei=佐藤
kn-aut-mei=勝紀
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=2
en-affil=
kn-affil=医薬基盤研究所生物資源研究部

affil-num=3
en-affil=
kn-affil=医薬基盤研究所生物資源研究部

affil-num=4
en-affil=
kn-affil=東海大学健康科学部

affil-num=5
en-affil=
kn-affil=医薬基盤研究所生物資源研究部

affil-num=6
en-affil=
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=9
article-no=
start-page=1305
end-page=1308
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Parathion-Splitting Enzyme. Part 2. Parathion-splitting activity of human blood serum and distribution of parathion-splitting enzyme in various organs of dogs
kn-title=パラチオン分解酵素に関する研究 �U. ヒト血清のパラチオン分解能及びパラチオン分解酵素の諸臓器（イヌ）内分布に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Human blood serum and various organs of dogs were determined for its content of parathion-splitting enzyme by the procedure presented in the preceding paper. Ten per cent saline suspension of the relevant homogenized tissues was used for the estimation of parathion-splitting enzyme of the organs. (1) The activity of the enzyme in blood serum of normal individuals was 134 ± 44.6 γ/ml for men and 180 ± 62 γ/ml for women. (2) Of the various organs of dogs the blood serum was the most abundant in the enzyme, and the liver, the lung, the bone marrow and the kidney followed in the order given. The distribution of the enzyme was not appreciable in other organs. (3) The blood, the liver, the lung and the bone marrow were thought to play a major part in the detoxication of parathion, because the afore-mentioned decomposition of this poison to the less toxic paranitrophenol was believed to imply detoxication. The blood will constitute the most important and the liver the next-important organ of detoxication, if volume of the organs is taken into account.
en-copyright=
kn-copyright=

en-aut-name=ShiigiTeiji
en-aut-sei=Shiigi
en-aut-mei=Teiji
kn-aut-name=椎木悌二
kn-aut-sei=椎木
kn-aut-mei=悌二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=山口県立医科大学臨床病理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=
article-no=
start-page=31
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1988
dt-pub=198808
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=気管支喘息および慢性気管支炎患者における抗ヒトIgEによる好塩基球からのヒスタミン遊離
kn-title=Basophil histamine release by anti-IgE in Subjects of chronic bronchitis and bronchial asthma
en-subtitle=
kn-subtitle=
en-abstract=気管支喘息50例，慢性気管支炎8例を対象に，抗ヒトIgE添加時の好塩基球からのヒスタミン遊離を全血法により行ない，その臨床的評価について検討を加えた。抗ヒトIgE海底時のMax　％　histamine releaseの平均は，健康人24.7±14.2％，慢性気管支炎27.7±22.1％，気管支喘息28.4±17.0％であり，3者間に有意の差はみられなかった。すなわち，抗ヒトIgE添加により健康人や慢性気管支炎患者の好塩基球からも有意のヒスタミン遊離が見られた。気管支喘息のなかでは，内因性喘息症例においてヒスタミン遊離（14.1±7.2％）の低い傾向が見られた。Dose-response curveの検討では，健康人，慢性気管支炎症例では全例E（2）からE（1）へかけてのnegative slopeを示した。気管支喘息症例では，血清IgE値500IU/ml以下の症例ではnegative slopeを示す症例が多く，一方501IU/ml以上の症例ではpositive slopeを示す症例がより多く見られた。
kn-abstract=Histamine release from basophils induced by anti-IgE was studied in 8 patients with chronic bronchitis and 50 patients with bronchial asthma by analyzing doseresponse curves. As the result, there were no significant differences in maximum percent histamine release from basophils among three groups of healthy subjects (24.7±
14.2%), patients with chronic bronchitis (27.7±22.1%) and those with bronchial asthma (28.4±17.0%). In the patients with bronchial asthma, the maximum percent histamine release was higher in accordance with higher serum IgE levels, and low maximum percent release was observed in patients with intrinsic asthma (14.1±7.2%).
Study of dose-response curves of anti-IgE-induced histamine release showed that a negative slope from E(2) to E(1) was observed in both healthy subjects and patients with chronic bronchitis. The majority of asthmatics with serum IgE levels of 501IU/ml or over showed a positive slope from E(2) to E(1).
en-copyright=
kn-copyright=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

en-aut-name=SudoMichiyasu
en-aut-sei=Sudo
en-aut-mei=Michiyasu
kn-aut-name=周藤真康
kn-aut-sei=周藤
kn-aut-mei=真康
aut-affil-num=2
ORCID=

en-aut-name=KitaniHikaru
en-aut-sei=Kitani
en-aut-mei=Hikaru
kn-aut-name=貴谷光
kn-aut-sei=貴谷
kn-aut-mei=光
aut-affil-num=3
ORCID=

en-aut-name=ArakiHiroyuki
en-aut-sei=Araki
en-aut-mei=Hiroyuki
kn-aut-name=荒木洋行
kn-aut-sei=荒木
kn-aut-mei=洋行
aut-affil-num=4
ORCID=

en-aut-name=TsujiMitsuaki
en-aut-sei=Tsuji
en-aut-mei=Mitsuaki
kn-aut-name=辻光朗
kn-aut-sei=辻
kn-aut-mei=光朗
aut-affil-num=5
ORCID=

en-aut-name=TakahashiKiyoshi
en-aut-sei=Takahashi
en-aut-mei=Kiyoshi
kn-aut-name=高橋清
kn-aut-sei=高橋
kn-aut-mei=清
aut-affil-num=6
ORCID=

en-aut-name=KimuraIkuro
en-aut-sei=Kimura
en-aut-mei=Ikuro
kn-aut-name=木村郁郎
kn-aut-sei=木村
kn-aut-mei=郁郎
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部三朝分院内科

affil-num=2
en-affil=
kn-affil=岡山大学医学部三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学医学部三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学医学部三朝分院内科

affil-num=5
en-affil=
kn-affil=岡山大学医学部三朝分院内科

affil-num=6
en-affil=
kn-affil=岡山大学医学部第2内科

affil-num=7
en-affil=
kn-affil=岡山大学医学部第2内科
en-keyword=Basophil response (好塩基球の反応性)
kn-keyword=Basophil response (好塩基球の反応性)
en-keyword=Anti-lgE (抗ヒトIgE)
kn-keyword=Anti-lgE (抗ヒトIgE)
en-keyword=Histamine release (ヒスタミン遊離)
kn-keyword=Histamine release (ヒスタミン遊離)
en-keyword=chronic bronchitis (慢性気管支炎)
kn-keyword=chronic bronchitis (慢性気管支炎)
en-keyword=bronchial asthma (気管支喘息)
kn-keyword=bronchial asthma (気管支喘息)
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=
article-no=
start-page=5
end-page=11
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1987
dt-pub=198708
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study on anti-allergic action of Terfenadine
kn-title=Terfenadineの抗アレルギー作用について
en-subtitle=
kn-subtitle=
en-abstract=Anti-allergic action of terfenadine, one of the H(1) receptor inhibitors, was examined by human basophil histamine release induced by anti-IgE or a specific allergen (house dust), and the release of leukotriens from leucocytes stimulated by Ca ionophore A23187. 1. Terfenadine did not inhibit the release of histamine from basophils of healthy subjects induced by anti-IgE, and also of patients with bronchial asthma induced by house dust when the in vitro examination was performed by a whole blood method. 2. Histamine release from basophils of patients with bronchial asthma was significantly inhibited
when washed leucocytes was preincubated with terfenadine in vitro. The release of LT B(4) from leucocytes was also inhibited. 3. In vivo examination of inhibitory action of terfenadine showed no effect on basophil histamine release of healthy subjects by anti-IgE and of asthmatic subjects by house dust, although skin test by house dust in these subjects was inhibited 60 min after administration in vivo.
These results show that terfenadine inhibits the release of chemical mediators from tissue mast cells, and basophils migrating into local allergic sites.
kn-abstract=選択的H(1)受容体拮抗薬であるTerfenadineの抗アレルギー作用，特にIgE系反応によるヒスタミン，およびCa ionophore A23187による好中球からのleukotrienes遊離に対する抑制作用を，ヒト末梢血白血球を用いて検討した。１．Terfenadineは，抗ヒトIgE刺激による健康人好塩基球および特異抗原刺激による気管支喘息患者好塩基球からのヒスタミン遊離に対して，全血法でのin vitro添加実験では有意の抑制作用を示さなかった。
2．洗浄白血球法によるin vitro添加実験では，Terfenadineは特異抗原および抗ヒトIgE刺激時の気管支喘息患者好塩基球からのヒスタミン，Ca ionophore　A23187刺激時のleukotriene B(4)遊離に対して有意の抑制効果を示した。3．Terfenadineの内服によるin vivoの抑制実験では，IgE系反応による健康人および気管支喘息患者好塩基球からのヒスタミン遊離に対して有意の抑制効果は見られなかったが，特異抗原による皮膚反応に対しては明らかな抑制作用が観察された。以上より，Terfenadineは，組織肥満細胞および組織へと遊走してきた好塩基球に対してはある程度の抑制作用を有しているものと考えられた。
en-copyright=
kn-copyright=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

en-aut-name=KomagoeHaruki
en-aut-sei=Komagoe
en-aut-mei=Haruki
kn-aut-name=駒越春樹
kn-aut-sei=駒越
kn-aut-mei=春樹
aut-affil-num=2
ORCID=

en-aut-name=SudoMichiyasu
en-aut-sei=Sudo
en-aut-mei=Michiyasu
kn-aut-name=周藤真康
kn-aut-sei=周藤
kn-aut-mei=真康
aut-affil-num=3
ORCID=

en-aut-name=KitaniHikaru
en-aut-sei=Kitani
en-aut-mei=Hikaru
kn-aut-name=貴谷光
kn-aut-sei=貴谷
kn-aut-mei=光
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部三朝分院内科

affil-num=2
en-affil=
kn-affil=岡山大学医学部三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学医学部三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学医学部三朝分院内科
en-keyword=夕一フェナンジン (Terfenadine)
kn-keyword=夕一フェナンジン (Terfenadine)
en-keyword=lgE系反応 (IgE-mediated reaction)
kn-keyword=lgE系反応 (IgE-mediated reaction)
en-keyword=ヒスタミン (histamine)
kn-keyword=ヒスタミン (histamine)
en-keyword=好塩基球 (basophils)
kn-keyword=好塩基球 (basophils)
END

start-ver=1.4
cd-journal=joma
no-vol=57
cd-vols=
no-issue=
article-no=
start-page=42
end-page=45
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=198607
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on anti-allergic actions of tranilast (Rizaben?)
kn-title=Tranilast(Rizaben?)の抗アレルギー作用について
en-subtitle=
kn-subtitle=
en-abstract=Tlanilast is clinically used for bronchial asthma as one of the prophylactic agents for asthma attacks. In this study, anti-allergic actions of tranilast were examined in (45)Ca uptake of and histamine release from target cells of IgE after stimulation with antigen, anti-IgE and camp. 48/80. 1. (45)Ca uptake of and histamine release from rat peritoneal mast cells stimulated by antigen were significantly inhibited by preincubation of the cells with tranilast. Inhibition by tranilast of increased (45)Ca uptake of mast cells by addition of phosphatidylserine were less, although inhibition of histamine release was not so affected by addition of phosphatidylserine. No significant inhibition by tranilast of (45)Ca uptake and histamine release was not observed when the cells were stimulated by camp. 48/80. 2. Tranilast showed any inhibitory effects on basophil histamine release induced by antigen and anti-IgE.
kn-abstract=抗アレルギー剤（脱顆粒抑制剤）の1つであるtranilastの肥満細胞の遊離機序に対する抑制作用について検討を加えた。1．抗原刺激時の肥満細胞の(45)Ca uptakeおよびヒスタミン遊離に対して，tranilastは有意の抑制作用を示したが，comp.48/80刺激時にはtranilastの(45)Ca uptake，ヒスタミン遊離に対する抑制作用はほとんどみられなかった。2．phosphatidylserine添加時には，(45)Ca uptakeに対するtranilastの抑制作用は減弱傾向を示し，この傾向はヒスタミン遊離に対する作用に比べより高度であった。3．抗原および抗ヒトIgEによる好塩基球からのヒスタミン遊離に対して，tranilastは明らかな抑制作用を示さなかった。
en-copyright=
kn-copyright=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

en-aut-name=KomagoeHaruki
en-aut-sei=Komagoe
en-aut-mei=Haruki
kn-aut-name=駒越春樹
kn-aut-sei=駒越
kn-aut-mei=春樹
aut-affil-num=2
ORCID=

en-aut-name=SudoMichiyasu
en-aut-sei=Sudo
en-aut-mei=Michiyasu
kn-aut-name=周藤真康
kn-aut-sei=周藤
kn-aut-mei=真康
aut-affil-num=3
ORCID=

en-aut-name=MorinagaHiroshi
en-aut-sei=Morinaga
en-aut-mei=Hiroshi
kn-aut-name=森永寛
kn-aut-sei=森永
kn-aut-mei=寛
aut-affil-num=4
ORCID=

en-aut-name=OhtaniJun
en-aut-sei=Ohtani
en-aut-mei=Jun
kn-aut-name=大谷純
kn-aut-sei=大谷
kn-aut-mei=純
aut-affil-num=5
ORCID=

en-aut-name=KimuraIkuro
en-aut-sei=Kimura
en-aut-mei=Ikuro
kn-aut-name=木村郁郎
kn-aut-sei=木村
kn-aut-mei=郁郎
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属環境病態研究施設基礎環境病態学分野

affil-num=2
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=3
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=4
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=5
en-affil=
kn-affil=岡山大学医学部第2内科

affil-num=6
en-affil=
kn-affil=岡山大学医学部第2内科
en-keyword=トラニラスト (tranilast)
kn-keyword=トラニラスト (tranilast)
en-keyword=(45)Ca取り込み ((45)Ca uptake)
kn-keyword=(45)Ca取り込み ((45)Ca uptake)
en-keyword=ヒスタミン遊離 (histamine release)
kn-keyword=ヒスタミン遊離 (histamine release)
en-keyword=肥満細胞 (mast cell)
kn-keyword=肥満細胞 (mast cell)
en-keyword=好塩基球 (basophils)
kn-keyword=好塩基球 (basophils)
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=5-1
article-no=
start-page=2293
end-page=2301
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590415
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Experimental Study of the Specific Protein Contained in Human Fetal Serum Globulin
kn-title=ヒト胎児血清グロブリン中に含有する特異蛋白に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1) When rabbits are immunized by human fetal serum, high titer precipitin reaction on human serum can be obtained by injecting ten times. 2) When rabbits are immunized by human fetal serum with Globulin and Albumin precipitin productions can be obtained easier than that of human fetal serum. As for each antigenity, the remarkable difference can not be seen and the antigenity of fetal serum Albumin is by no means inferior to that of Globulin. 3) In case of fetal serum Albumin as antigen, precipitin quantity is lower than that of Globulin, and appearance of reaction is less. 4) Specific protein contained in fetal serum, exists in serum Globulin, not in Albumin.
en-copyright=
kn-copyright=

en-aut-name=MiyoshiYoshinori
en-aut-sei=Miyoshi
en-aut-mei=Yoshinori
kn-aut-name=三好義則
kn-aut-sei=三好
kn-aut-mei=義則
aut-affil-num=1
ORCID=

en-aut-name=OchiaiYoshiyuki
en-aut-sei=Ochiai
en-aut-mei=Yoshiyuki
kn-aut-name=落合義幸
kn-aut-sei=落合
kn-aut-mei=義幸
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=2-1
article-no=
start-page=555
end-page=565
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Sero-immunological Studies of the Specific Protein Contained in Human Meconium
kn-title=ヒト胎便中に含有する特異蛋白の血清免疫学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Author intended the sero-immunologic studies of human meconium as the series of studies concerning fetal serum, placenta and so on, and then obtained the results as follows; 1) When rabbits are injected repeatedly with the extract of human meconium, the antiserum can be obtained high titer precipitin reaction on human serum. 2) Researching production of precipitin about rabbit's serum immunized with human meconium of the 7, 8, 9 and 10th pregnant months separatedly, author cannot find striking differences on antigenity in each months. 3) Rabbit's serum immunized with human meconium has very strong species specifity. 4) In human meconium exist specific protein fractions which are not contained in the adult human serum and these fractions are considered to coincide with those exist in the fetal serum and there were very small quantities.
en-copyright=
kn-copyright=

en-aut-name=MiyoshiYoshinori
en-aut-sei=Miyoshi
en-aut-mei=Yoshinori
kn-aut-name=三好義則
kn-aut-sei=三好
kn-aut-mei=義則
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=7
article-no=
start-page=2415
end-page=2426
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=1958
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the Allergic Histological Changes that have occurred on the Organs of Pregnant Rabbits due to Injection of Human Placental Extract as well as Fetal Serum Protein
kn-title=ヒト胎盤ならびに胎児血清蛋白による妊娠ウサギ臓器のアレルギー性組織変化について 第2編 ヒト胎児血清,胎盤ならびに羊水蛋白による妊娠ウサギ臓器のアレルギー性組織変化について
en-subtitle=
kn-subtitle=
en-abstract=It has been discovered that there exists, within the fetal serum, as well as human placental extract and an amniotic fluid, the specific protein that hadn't found out in any human adult serum; which has the similar subjects to above. They were repeatedly injected to pregnant rabbits as antigens, and the following are the results. There are caused the allergic histological changes on liver and kidney outstandingly, the changes are alike to the organs of pregnant toxicosis, and are the most strongest when injected placental protein, more stonger fetal serum than amniotic fluid. However any differences cann't find out among themselves histologically, so the author has considered that the specific protein is caused to the above said changes.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkamuraYasumasa
en-aut-sei=Okamura
en-aut-mei=Yasumasa
kn-aut-name=岡村安政
kn-aut-sei=岡村
kn-aut-mei=安政
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=1
article-no=
start-page=97
end-page=103
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the Allergic Histologial Changes that have occurred due to Human Placenta as well as Fetus Serum Protein in Pregnant Rabbit's Organs
kn-title=ヒト胎盤ならびに胎児血清蛋白による妊娠ウサギ臓器のアレルギー性組織変化について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=It has been discovered that there exists, within the fetus serum, as well as human placenta, a similar specific protein that one cannot find out in any human serum; which has been considered to have been formulated in placenta; further, one can probe out the abovesaid unique protein part in a show alike.
en-copyright=
kn-copyright=

en-aut-name=OkamuraYasumasa
en-aut-sei=Okamura
en-aut-mei=Yasumasa
kn-aut-name=岡村安政
kn-aut-sei=岡村
kn-aut-mei=安政
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部法医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=5-7
article-no=
start-page=1463
end-page=1469
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600730
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Influences of Electrical Stimulation (In Vitro) on the Metabolism of the Brain Part 3. Influences of Electrical Stimulation (in vitro) on the Cerebral Transamination
kn-title=電気刺戟（in vitro）の脳物質代謝におよぼす影響 第3編 電気刺戟（in vitro）の大脳トランスアミネーションにおよぼす影響
en-subtitle=
kn-subtitle=
en-abstract=With the use of homogenate of the brains and cerebral cortex slices obtained from albino rats, Pithecus monkey and human, the author observed the influences of electrical stimulation (in vitro) on the fransamination, and obtained the following results. 1. In the case of albino rat cerebrum the electrical stimulation inhibited the synthesis of glutamic acid from the aspatic acid 14.6 per cent with homogenate and 9.6 per cent with slices. Namely, the rate of such inhibition seems to he greater in the case of homogenate than in the case of slices. In addition, in the alanine series ne marked changes could be recognired but in GABA series all tended to receive a slight inhibitory effect. In all cases, however, the rate of reactivity is diminished more with slices than with homogenates. 2. In the case of the cerebral cortex homogenate of monkey, the electrical stimulation inhibited the glutamic and production in the aspartic acid seriet about 11 per cent on the average. In the case of the normal human cerebral cortex slices, the electrical stimulation accelerated the glutamic acid production about 11.3 per cent on the average, while in the case of atrophic human cerebral cortex homogenate hardly any changes could be recognized. In comparing the rats of reactivity in the case of the normal human cerebral cortex slices it is about 20 per cent higher both in the control group and experimental group than in the case of the slices of albino rats. In the cisa of the atrophic human cerebral cortex homogenate the reactivity was slightly lower than in the case of albino rats.
kn-abstract=1) ダイコクネズミ,タイワンザル,ヒト脳の大脳ホモジネートおよび大脳皮質切片を用いて電気刺戟(in vitro)のトランスアミネーションにおよぼす影響をみた. 2) ダイコクネズミ大脳においてはAsGT活性は電気刺戟によつてホモジネートでは14.6%切片では9.6%阻害された.すなわちホモジネートの方が切片より阻害率は著明なようであつた.またAIGT活性は電気刺戟によつてホモジネート,切片とも著変なく,γAGT活性は電気刺戟によつてホモジネート,切片とも阻害傾向を示した.そこでAIGTは酵素系が異なるためではないかと推論した.また反応率はいづれの場合も切片の方がホモジネートより減少していた. 3) タイワンザル大脳皮質ホモジネートにおいてはAsGT活性は電気刺戟によつて平均約11%阻害された.またヒト健常大脳皮質切片においてはAsGT活性は電気刺戟によつて平均約11.3%の促進をみ,ヒト萎縮大脳皮質ホモジネートにおいては殆ど変化をみなかつた.また反応率を比較するとヒト健常大脳皮質切片ではダイコクネズミの切片の場合に比し対照時,刺戟時ともに約20%高く,ヒト萎縮大脳皮質ホモジネートではダイコクネズミのそれに比しやや低い値を示した.すなわち萎縮脳のAsGT活性の低下が考えられる.
en-copyright=
kn-copyright=

en-aut-name=KumashiroHisashi
en-aut-sei=Kumashiro
en-aut-mei=Hisashi
kn-aut-name=熊代永
kn-aut-sei=熊代
kn-aut-mei=永
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=10
article-no=
start-page=903
end-page=912
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19631030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 3. Megakaryocytes in the Human Spleen
kn-title=脾組織培養法による脾内巨核球に関する研究 第3編 ヒト脾内巨核球について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Followings are the results of studies by our clinical tissue culture method mainly on motility and ability of platelet formation of megakaryocytes in the spleen of human embryo and a patient with osteomyelofibrosis. 1) Megakaryocytes are always found in the spleen of human embryo, and no significant morphological differences are noted from those in the bone marrow. 2) Deformated movement, pseudopodial movement, and tentacle formation for the platelet formation are noted on megakaryocytes in the spleen of human embryos. As for functions of megakaryocytes, motility and ability of the platelet formation are significantly found at 4 month of age, but are remarkably decreased after 5 month of age. 3) A correlation is noted in human embryo between the functions of megakaryocytes and erythropoiesis in the spleen, a rise and fall of the one being accompanied by the other. 4) In a patient with osteomyelofibrosis, megakaryocytes found in the spleen show a remarkable decrease in the functions.
en-copyright=
kn-copyright=

en-aut-name=HanzawaAtsumasa
en-aut-sei=Hanzawa
en-aut-mei=Atsumasa
kn-aut-name=半澤敦正
kn-aut-sei=半澤
kn-aut-mei=敦正
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=5-7
article-no=
start-page=1299
end-page=1306
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600730
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Free Amino Acids in the Brains XIII A Study on the Free Amino Acids in Various Parts of Human Brain
kn-title=脳の遊離アミノ酸について(XIII) ヒト脳各部位の遊離アミノ酸およびその関連物質
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By means of ion exchange column chromatography the author carried out quantitative analyses of 14 kinds of free amino acids including the related compounds using the brain of the person who died of acute loss of blood. The parts of the brain used for the analysis were frontal cortex, corpus callosum, caudate nucleus, globus pallidus, thalamus, hypothalamus and medulla oblongata. The results are as follows. 1. In corpus callosum which contains little cellular components extremely minute quantities of phosphoethanolamine, aspartic acid, glutamic acid and γ-aminobutyric acid could be detected. 2. In globus pallidus a surprisingly large quantity of γ-aminobutyric acid could be found and it was far greater than that contained in hypothalamus. 3. In medulla oblongata only small quantities of phosphoethanolamine, aspartic acid, and glutamic acid could be detected. Likewise γ-aminobutyric acid was found not so abundant. This seems to be due to the fact that the present experiment was conducted with medulla oblongata including white matter. 4. Although only in a small quantity, cystathionine could be assayed in all these parts except globus pallidus and thalamus. 5. Even from the comparative biochemistry the present quantitative analyses gave an interesting contrast to the values obtainable in the brains of lower animals. 6. Although it was difficult to recognize any distinct difference in the pattern of amino acids between the adult brain and the infant brain, there was a clear-cut difference in the amino acid pattern of the adult brain and that of the fetal brain. Namely, in the adult human brain there exist far greater quantities of aspartic acid, glutamic acid, γ-aminobutyrie acid, and N-acetylaspartic acid than those in the fetal brain and conversely far less quantities of phosphoethanolamine and taurine than in the latter. Likewise tyrosine detected in the fetal brain could not be recognized in the adult human brain.
en-copyright=
kn-copyright=

en-aut-name=NishiokaHirosuke
en-aut-sei=Nishioka
en-aut-mei=Hirosuke
kn-aut-name=西岡博輔
kn-aut-sei=西岡
kn-aut-mei=博輔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=2
article-no=
start-page=507
end-page=513
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Transaminase of Brain (I) Transaminase Activities of the Monkey and Human Brain
kn-title=脳のトランスアミナーゼ 第1編 タイワンザル脳およびヒト脳におけるトランスアミナーゼ活性について
en-subtitle=
kn-subtitle=
en-abstract=The author measured the transaminase activities of eighteen amino acids with α-keto-glutarate in a Pithecus monkey brain and in two human brains, one obtained from a man died from accident and another from a woman died of senile psychosis due to brain atrophy. 1. In the monkey brain, alanine and valine showed low activities in the cerebral cortex in comparison with other parts but γ-amino-β-hydroxybutyric acid showed a low activity. 2. In normal human brain, lower activities of valine, leucine and three ω-amino acids were showed in the cerebral cortex, which were different from the monkey and lower vertebrates. 3. The markedly atrophic cerebral cortex was more similar to the lower vertebrates than to the normal human brain in high activities of alanine, leucine, valine and γ-amino-β-hydroxybutyric acid. But an increase of activities of histidine, proline and ornithine was not similar to both of normal human and animal brain. These high activities of histidine and praline correspond unlikely to the transamination only.
kn-abstract=タイワンザル脳，事故死ヒト脳の大脳皮質，大脳白質および小脳皮質，さらに高度の脳萎縮を伴い老人性痴呆にて死亡したヒト脳の大脳皮質を用い， 11種のα-アミノ酸， 3種のω-アミノ酸， 3種のヂアミノ酸，システイン酸，タウリンについて，組織のトランスアミナーゼ活性を測定した. 1. タイワンザル脳では，大脳皮質においてアラニンとバリンの活性が他部より低く，γ-アミノ酪酸とγ-アミノ-β-オキシ酪酸が高い. 2. 健常人脳では，アスパラギン酸，セリンが大脳皮質に，ヒスチジン，ロイシン，バリンが小脳皮質にて他部より高く，アラニン，フエニールアラニン，システイン酸は大脳白質において低い活性を示した. 3. タイワンザルおよび健常ヒト脳の大脳皮質では，いずれもアスパラギン酸，グリシン，フエニールアラニン，オルニチン，システイン酸の高い活性，およびアラニンの低い活性の点で他の下等動物脳と異なる. 4. 健常ヒト大脳皮質は，バリン，ロイシンおよび3種のω-アミノ酸の低い活性を以つてサルおよび下等動物と異なる. 5. 萎縮したヒト大脳皮質は，アラニン，ロイシン，バリン，γ-アミノ-β-オキシ酪酸の活性が健常ヒト大脳皮質より高く，むしろ下等動物のそれに近い.ヒスチジン，プロリン，オルニチンのグルタミン酸生成の著しい増加は健常ヒト脳および下等動物脳のいずれとも異なるが，ヒスチジンとプロリンはトランスアミナーゼ活性増加のみによるものかどうか疑わしい.
en-copyright=
kn-copyright=

en-aut-name=OnoMasaya
en-aut-sei=Ono
en-aut-mei=Masaya
kn-aut-name=小野昌也
kn-aut-sei=小野
kn-aut-mei=昌也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=80
cd-vols=
no-issue=7-8
article-no=
start-page=665
end-page=676
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1968
dt-pub=19680830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Enzyme Histochemistry of the Cerebellum with a special reference to α-glycerophosphate dehydrogenase in Purkinje cells and the problem of the fixation of the material
kn-title=小脳の酵素組織化学―特にプルキンエ細胞のα-グリセロ燐酸脱水酵素と「固定の問題」をめぐつて―
en-subtitle=
kn-subtitle=
en-abstract=With the cerebellum of albino rat, human and cat as the material the activities of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), and α-glycerophosphate dehydro-genase (α-GPDH) were studied histochemically. For the identification of SDH and α-GPDH, menadione (MD) was added to the incubation medium as an intermediator. In the freshly-prepares cryostat sections of the cerebellum, the activities of LDH and SDH, as has already been reported, have been found in the granular layer (glomeruli cerebellosi), molecular layer and Purkinje cells (P-cells), but the activity of α-GPDH has hardly been detected in P-cell layer. In contrast to this findings, when the tissue block was first fixed with cold formalin solution and then frozen sections were prepared, in the course of identification of α-GPDH the formation of Nitro-BT formazans was observed in P-cells. This fact in dicates that a special precaution is required in the selection of methods and the determination of results inthe enzyme histochemistry. From this point of view, the establishment of various experimental conditions optimal for such a study have been tried　with a specal reference to the problem of the fixation.
The following results have been fouud with regard to the reaction in the sections fixed with formalin: 1) there is no marked difference due to the length of fixation time: 2) there is little effect due to the change in pH: 3) no specific inhibitory effect can be observed: 4) the presence of MD is prerequisite;　5) SH-group is involved; and 6) the enhancement of incorporation (adsorption; cf: substativity; Pearse) of Nitro-BT to the tissue is associated with the reaction. From these findings I have postulated that the reaction observable in the formalinfixed sections results from non-enzymic reaction in which SH-group and MD are involved, on the assumption that Nitro-BT is bound to the tissue protein. Furthevmore, the findings that P-cells do hardly exhibit the activity of α-GPDH in the non-fixed sections different from other cellular components of cerebellar tissue, as well as the fact that the non-enzymic recuction of Nitro-BT appears markedly in P-cells of the formalin-fixed specimen, seem to reflect one aspect of the cytochemical specificity of the P-cells.
kn-abstract=(1) ダイコクネズミ及びヒト,ネコの小脳について,乳酸脱水素酵素(LDH),コハク酸脱水素酵素(SDH),α-グリセロ燐酸脱水素酵素(α-GPDH)活性を組織化学的に検索した. SDH,α-GPDHの検出にあたつてはintermediatorとしてmenadione (MD)を反応液に添加した. 新鮮凍結クリオスタット切片にて,LDHは顆粒層の“gloneruli cerebellosi”に相当して最も強く,分子層ではformazan顆粒はびまん性に形成されて反応は顆粒層よりやや弱くPurkinje細胞(P-細胞)は核を除いて細胞体に強度〜中等度の活性を示し,白質には活性はほとんど証明されなかつた. SDHは全体としてLDHの反応態度に似た像を示し,顆粒層に最も強く,ついでP-細胞層,分子層の順で活性が認められ,白質にはほとんど証明されなかつた. α-GPDH反応は,顆粒層,分子層においてはLDH, SDHとほぼ同じであるが,P-細胞層にはformazanの形成がほとんどなく,あたかも顆粒層と分子層の間に空隙がある様な像を示した.白質には活性はほとんど証明されなかつた,これらの所見は,これまでの報告にほぼ一致するものである. (2) 上記酵素活性の検出にあたり,新鮮凍結クリオスタット切片とともに,同一材料について組織塊をまず10%冷フォルマリンで固定した後に作製した凍結切片をあわせて使用した. SDH,α-GPDH, LDHともに反応は全般に減弱されるが,LDHの反応の減弱の度合は他の2者にくらべて少ないようであつた.
ここで注目すべきことは,非固定切片のP-細胞層において,α-GPDHの活性がほとんど認められなかつたにもかかわらず固定切片のP-細胞には反応が認められ,しかもformazan形成は他の部よりもむしろ強度であつた点である.この事実は酵素組織化学における方法の選定や結果の判定にあたつては常に慎重な配慮が要求されることを示す現象であるとみなされ,この点に着目し特に固定の問題をめぐつて諸種の条件を実験的に設定してしらべた. (3) フォルマリン固定切片における反応には, i) 固定時間の長さによる著明な差異がみられない. ii) pHの変化による影響が少ない. iii) 特異的抑制剤による影響がみられない. iv) MDの存在が不可欠である. v) SH-基の関与がある. vi) Nitro-BTの組織への吸着性の増強が関連している. ということを認めた. このことからフォルマリン固定切片に見られる反応は,Nitro-BTの組織蛋白との結合性を前提とて,SH-groupとMDとが関与している非酵素的作用の結果であることを推論した. (4) 小脳組織でP-細胞が他の細胞要素と異なり,非固定切片においてα-GPDH活性をほとんど示さないこと,およびフォルマリン固定によりP-細胞に非酵素的なNitro-BT還元が著明にあらわれることは,P-細胞の細胞化学的特異性の一面を示すものであろう.
en-copyright=
kn-copyright=

en-aut-name=TokunagaIwao
en-aut-sei=Tokunaga
en-aut-mei=Iwao
kn-aut-name=徳永五輪雄
kn-aut-sei=徳永
kn-aut-mei=五輪雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=3-4
article-no=
start-page=271
end-page=280
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1967
dt-pub=19670430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Malic Dehydrogenese Isozyme Part �U. A Study on Malic Dehydrogenese Isozymes of Human Serum and Rat organs during Development
kn-title=リンゴ酸脱水素酵素のアイソザイムに関する研究 第2編 ヒト血清及び発育過程におけるラット臓器のリンゴ酸脱水素酵素アイソザイムについて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Malic dehydrogenese (MDH) activities in human serum of various diseases were studied. Elevation of MDH activities were observed in myocardial infarction, acute hepatitis, and some malignant tumors. Characteristic MDH isozyme patterns were obtained from serum of patients with myocardial infarction and acute hepatitis showing marked elevation of MDH activities. During the tetrazolium procedure for staining of electrophoreticaly separated serum malic or lactic dehydrogenese isozymes on agargel, without substrate and co-enzyme, two peaks were noticed and named serum "non-specific factor". These peaks were considered a kind of non specific reactions which resulted from a reduction of the tetrazolium salt electrostaticaly adsorbed on Alb. 〜 α(1), Glb. by SH-groups of these serum proteins. These reactions were accelerated by the elavation of PH or the temperature, exposure during staining and the prolonged staining time, as well as the rise of concentrations of NTB, PMS and CN- in the staining medium. Considering of optimal conditions of enzyme reaction, the minimum use of NTB, PMS and Na CN, washing stained agargels with PH 4.5 acetic acid SoL, and complete shading during procedure could minimize the influence of this factor. Two MDH isozymes were demonstrated in agargel isozymograms of rat organs, one migrating towards the cathod and the other toward the anode. The cathodal fraction was considered mitochondrial MDH (m-MDH), and the anodal one cytoplasmic MDH (c-MDH), respectively. During development, m-MDH showed marked increase in heart muscle. In contrast to this, cMDH of liver and gastric mucosa increased in procedure of development. On the other hand the ratio of m-MDH and c-MDH in kidney remained constant through development.
en-copyright=
kn-copyright=

en-aut-name=TakayasuMasao
en-aut-sei=Takayasu
en-aut-mei=Masao
kn-aut-name=高安正雄
kn-aut-sei=高安
kn-aut-mei=正雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=3-4
article-no=
start-page=259
end-page=270
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1967
dt-pub=19670430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Malic Dehydrogenese Isozyme Part �T. A Study on Malic Dehydrogenese Activities and Isozymes of Various Human Organs
kn-title=リンゴ酸脱水素酵素のアイソザイムに関する研究 第1編 ヒト各種臓器のリンゴ酸脱水素酵素活性及びアイソザイムについて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Malic dehydrogenese (MDH) activities and isozymes of various human organs were measured. The assays of isozyme were carried out by means of agargel electrophoresis. The highest MDH activity was demonstrated in heart muscle. Liver, skeletal muscle, kidney and brain showed considerably high MDH activities. Six fractions were distinguished in many MDH isozymograms. In order of movility towards the cathod, each MDH isozyme was named MD(1), MD(2)…MD(6). Intracellular distribution of each MDH isozyme was investigated by means of cell fractionation, and MD(1)〜MD(5) were confirmed mitochondrial, MD(6) cytoplasmic, in origin. MDH isozyme-patterns of human organs were divided into 3 groups according to the ratio of mitochondrial MDH (m-MDH) and cytoplasmic MDH (c-MDH).
Group �T (m-MDH>c-MDH): heart muscle, kidney, skeletal muscle, white blood cell, red blood cell and lung-tissues.
Group �U (m-MDH≒c-MDH): liver, pancreas. Group �V (This group situates between Group �T and Group �U): brain, gastric mucosa, and spleen. Studies on inhibitory effect of p-chlor-mercuri-benzoate (PCMB) on each MDH isozyme and heat stability of each MDH isozyme demonstrated that m-MDH was not inhibited by PCMB and stable to a heat test at 50℃ for 30,' when 1-malate was used as substrate. It was also observed that m-MDH was activated by a high concentration of 1-malate. According to the standard deviation of MD(6) and MD(3) activites, c-MDH considered regulatory enzyme and m-MDH constitutive enzyme, respectively.
en-copyright=
kn-copyright=

en-aut-name=TakayasuMasao
en-aut-sei=Takayasu
en-aut-mei=Masao
kn-aut-name=高安正雄
kn-aut-sei=高安
kn-aut-mei=正雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=82
cd-vols=
no-issue=5-6
article-no=
start-page=295
end-page=317
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1970
dt-pub=19700630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evoked Cortical Responses after the Stimulation of Specific and Unspecific Nuclei of the Thalamus of the Human and Cats
kn-title=ヒトおよびネコの視床核電気刺激による皮質誘発反応に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cortical evoked responses after single or repetitive stimulations of the nucleus ventralis lateralis (VL), n. centrum medianum (CM) and n. ventralis anterior (VA) were observed in 61 cases of parkinsonism, 7 cases of intractable pain and a case of dystonia musculorum deformans from February, 1968 to December, 1969. Experimental studies of the thalamic stimulations with 15 cats were performed as well and the results were compared with that of the human. Evoked responses were analysed with averaging computer technique. Results were as followings. 1) Cortical evoked potentials after single stimulation of the VL nucleus of the human thalamus. a) Evoked potentials appeared on the ipsilateral centro-frontal regions with weaker stimulation in EEG records. However, the evoked potentials showed clear bilateral distribution except the temporal region, predominantly on both centro-frontal regions, with stronger stimulation electroencephalogaphically. b) The evoked potentials of the central site showed clear three negative waves within 200 msec after the stimulation, that is, the first negative wave (�T-N) with the peak time of about 10 msec, the second (positive-) negative wave (�U-PN) with the peak time of about 50 msec and the third negative wave (�V-N) with that of 80-100 msec with averaging computer records. The peak time of the �T-N wave and the negative phase of the �U-PN wave were nearly constant, but that of the �V-N wave considerably varied according to the background activities of EEG. The evoked potentials showed no significant discrepancy between right and left patterns, and moreover, they maintained a similar pattern when the stimulating voltages were changed. c) Bilateral evoked potentials were clearly seen with averaging computer technique even when evoked potentials were small and hardly identified on the contralateral scalp with EEG records. When the stimulating voltages were gradually decreased, the ipsilateral and contralateral evoked potentials disappeared approximately at the same time. d) The latency of the �T-N wave was measured to be 5-6 msec with averaging computer records, and the amplitude of the �T-N wave increased proportionately with the increase of stimulating voltages.
en-copyright=
kn-copyright=

en-aut-name=NambaShimpei
en-aut-sei=Namba
en-aut-mei=Shimpei
kn-aut-name=難波真平
kn-aut-sei=難波
kn-aut-mei=真平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学脳神経外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=84
cd-vols=
no-issue=11-12
article-no=
start-page=575
end-page=593
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=19721230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Fine Structure of Human Normal Gall Bladder and Cholesterosis
kn-title=ヒト胆嚢粘膜及び胆嚢コレステローシスの電子顕微鏡的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Human gall bladders specimens obtained soon after cholecystectomy from 50 patients were observed under electron microscopy. Four types of cells were distinguished by light and electron microscopy in the human gall bladder epithelium, i.e.,"Ordinary epithelial cell", "Clear cell", "Dark cell", and" Basal cell". The Clear cell have been subdivided at least two types by electron microscopy. One was degenerative type and another was immatured one. It was also observed that the mechanism of discharge of secretory granules was the" Merocrine mode". In the cholesterosis, it was assemed that cholesterol was absorbed into the epithelial cells from the bile and accumlated in their basal area, then discharged through their basis. It was taken by phagocytes which gradually transformed into the foamy cells.
en-copyright=
kn-copyright=

en-aut-name=TakahashiKimio
en-aut-sei=Takahashi
en-aut-mei=Kimio
kn-aut-name=高橋公雄
kn-aut-sei=高橋
kn-aut-mei=公雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第�T外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=84
cd-vols=
no-issue=11-12
article-no=
start-page=395
end-page=396
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=19721230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=低カタラーゼ血液症の簡易検出法に関する研究 第2編 ヒト血液凍結保存によるカタラーゼ活性度の変動について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=高越良明
kn-aut-sei=高越
kn-aut-mei=良明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=84
cd-vols=
no-issue=11-12
article-no=
start-page=391
end-page=393
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=19721230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=低カタラーゼ血液症の簡易検出法に関する研究 第1編 ヒト血液保存によるカタラーゼ活性度の変動について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=高越良明
kn-aut-sei=高越
kn-aut-mei=良明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=84
cd-vols=
no-issue=9-10
article-no=
start-page=247
end-page=266
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=19721030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Thalamo-cortical Relationship in Evoked Cortical Responses Following Human Ventrolateral Thalamic Stimulation
kn-title=Thalamo-cortical Relationに関する電気生理学的研究-ヒト視床腹外側核刺激による皮質誘発反応の分析-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Electrophysiological studies on evoked cortical potentials following ventrolateral (VL) thalamic stimulation of man were performed with averaging computer technique for 41 patients of parkinsonism and other involuntary movement disorders during stereotaxic surgery for last 2 years. 1. Single stimulation of the VL nucleus demonstrated bilateral cortical activity with I-PN (first positive negative), �U-PN (second positive negative), �V-PN (third positive negative) and �W-PN (fourth positive negative) waves. �V-P wave was frequently superimposed on negative response between �U-N and �V-N wave, and �W-PN waves were frequently feeble in single stimulation of the VL nucleus. 2. Peak latencies of these waves were estimated 3.4±1.2 msec in �T-P, 10.6±1.8 msec in �T-N, 29±5 msec in �U-P, 55±6 msec in �U-N, 71±11 msec in �V-P, 90±11 msec in �V-N, 115±19 msec in �W-P and 160±24 msec in �W-N wave in ipsilateral central lead, and 4.0±1.5 msec in �T-P, 11.1±2.1 msec in �T-N, 31±4 msec in �U-P, 57±6 msec in �U-N, 74±13 msec in �V-P, 92±12 msec in �V-N, 118±24 msec in �W-P and 156±29 msec in �W-N wave in contralateral central lead. 3. The first deflection time of �T-P wave, which meant beginning of the evoked response, was 1.5-1.8 msec in stimulated side of central cortex and 2.2-2.9 msec in contralateral central lead, which were obtained in 5 cases precisely measured. 4. The impulse, which provoked �T-P N waves, was thought to be conducted from stimulated VL nucleus to the contralateral cortex directly via corpus callosum with 36-43m/sec of velocity. 5. Cortical evoked responses following suprathreshold low frequency stimulation (5-12Hz) of the VL nucleus showed invariably augmenting response and recruiting-like augmenting response. Augmenting response, which consisted of a train of growth in both. positive and negative components, was evoked when each stimulus was given on the descending phase from the peak of �V-N or augmented negativiy to the bottom of following positive wave of the preceding response. Analysis of augmentation suggested that synchronization of preceding evoked �W-P and present �U-P wave would be occured in augmented positivity and synchronization of preceding evoked �W-N and present �U-N or �V-N wave would be occured in augmented　negativity. Recruiting-like augmenting response was obtained when each stimulus was given on the ascending phase from the bottom of deep �W-P to the following negative wave of the preceding response. Recruiting-like augmentation was shown to be a similar response as augmenting response in the fundamental pattern of averaged evoked activity, although development of negativity and attenuation of positivity caused recruiting-like pattern. Component analysis of recruiting-like augmenting response revealed that predominant development of negativity was thought to be the result of the synchronization of preceding evoked �W-N and present �U-N or �V-N wave. And attenuation of �U-P wave was thought to be the result of the desynchronization of preceding �W-N and present �U-P wave. Responses following lower frequency stimulation with 4Hz or less were similar to responses following single stimulation. Subthreshold stimulation were thought to be difficult to induce any growth of negative cortical response. 6. It was clarified that cortical evoked response following stimulation of the VL nucleus was influenced by components and phases of the preceding cortical response, suggesting that human specific thalamic system would play a possible important role in modulation upon cortical electrical activity.
en-copyright=
kn-copyright=

en-aut-name=MiyamotoToshihiko
en-aut-sei=Miyamoto
en-aut-mei=Toshihiko
kn-aut-name=宮本俊彦
kn-aut-sei=宮本
kn-aut-mei=俊彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学脳神経外科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=86
cd-vols=
no-issue=7-8
article-no=
start-page=403
end-page=408
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1974
dt-pub=19740830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cultivation of Human Lymphoblastoid Cells in Diffusion Chambers Implanted in the Abdominal Cavity of Mice�U. Propagation of Rauscher Leukemia Virus to HumanLymphoblastoid Cells
kn-title=マウス腹腔内な挿入されたdiffusion chamber内でのヒトリンパ芽球様株細胞の培養 第2編 ヒトリンパ芽球様株細胞へのRauscher白血病ウィルスの感染
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Diffusion chambers containing EBV-bearing human lymphoblastoid cells were placed temporarily within the peritoneal cavity of BALB/c mice with Rauscher leukemia. Reestablished human leukocyte cultures became dually infected with C type and EBV particles and have continuously produced abundant C type particles. These virus particles were nonleukemogenic when inoculated into BALB/c mice but afforded some protection against challenge infection with spleen-derived leukemogenic RLV.
en-copyright=
kn-copyright=

en-aut-name=YoshimotoShuko
en-aut-sei=Yoshimoto
en-aut-mei=Shuko
kn-aut-name=吉本修子
kn-aut-sei=吉本
kn-aut-mei=修子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
END

start-ver=1.4
cd-journal=joma
no-vol=86
cd-vols=
no-issue=7-8
article-no=
start-page=393
end-page=401
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1974
dt-pub=19740830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cultivation of Human Lymphoblastoid Cells in Diffusion Chambers Implanted in the Abdominal Cavity of Mice �T. Morphologic Alteration of Human Lymphoblastoid Cells
kn-title=マウス腹腔内に挿入されたdiffusion chamber内でのヒトリンパ芽球様株細胞の培養 第1編 ヒトリンパ芽球様株細胞の形態学的変化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A clonal lymphoblastoid cell line derived from lymph node of a patient with Hodgkin's diseasewas cultivated in diffusion chambers implanted in the abdominal cavity of mice and cellular morphologic changes were sequentially studied for up to 8 weeks. The majority of cells before intraperitoneal implantation were lymphoblasts with approximately 16% mature lymphocytes. However, after 3 weeks of in vivo cultivation in diffusion chambers, macrophage-like cells began to increase and occupied 80-90% of cells after 4 and 5 weeks. These macrophage-like cells, when tested for phagocytic activity after 4 weeks, exhibited bacterial phagocytosis. Labeling studies with (3)H-thymidine indicated that active DNA synthesis continued for up to 2 weeks of in vivo diffusion chamber cultivation, during which mitotic figures were also observed morphologically. Further, it was attempted to recultivate in vitro cells that were taken out of diffusion chambers after 2, 3, and 4 weeks of in vivo implantation. These 3 separate attempts led to the development of lymphoblastoid cells that were morphologically and cytogenetically similar to those prior to diffusion chamber implantation. From these findings, it is suggested that human lymphoid cells undergo morphologic alteration to macrophages under certain circumstances.
en-copyright=
kn-copyright=

en-aut-name=YoshimotoShuko
en-aut-sei=Yoshimoto
en-aut-mei=Shuko
kn-aut-name=吉本修子
kn-aut-sei=吉本
kn-aut-mei=修子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
END

start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=11-12
article-no=
start-page=569
end-page=578
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=19711230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of lymphoblastoid cell lines derived from human peripheral blood leukocytes. Part 11. Immunofluorescence study
kn-title=ヒト末梢血由来リンパ芽球様株細胞に関する研究 第2編 蛍光抗体法による研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Three types of investigations by the immunofluorescence method were performed. Antibody to EB virus (EBV) in various sera and EBV antigen in the nine lymphoblastoid cell lines were tested by the indirect method and production of immunoglobulin in these cell lines was by the direct method. 1) It has been shown that the virus is widely disseminated among normal persons in Japan. 2) Newborn infants possess EBV antibody on delivery. This antibody is probably transmitted from mother to fetus via the placenta. 3) There is no difference in EBV antibody titers between normal individuals and donors from whom the lymphoblastoid cell lines were established. 4) EBV antigen appears in a small number of lymphocytes and macrophages within a few weeks after initiation of peripheral leukocyte cultures. 5) All the established cell lines persistly demonstrate a few percentage of EBV antigen-positive cells. 6 ) All the cell lines produce two or three classes of immunoglobulin but the proportion of the stained cells varies considerably during long-term culture.
en-copyright=
kn-copyright=

en-aut-name=HasegawaHarumi
en-aut-sei=Hasegawa
en-aut-mei=Harumi
kn-aut-name=長谷川晴巳
kn-aut-sei=長谷川
kn-aut-mei=晴巳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
END

start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=11-12
article-no=
start-page=553
end-page=567
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=19711230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of lymphoblastoid cell lines derived from human peripheral blood leukocytes. Part 1. Establishnent of 9 new cell lines
kn-title=ヒト末梢血由来リンパ芽球様株細胞に関する研究 第1編 リンパ芽球様株細胞の樹立
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Nine new lymphoblastoid cell lines have been established from peripheral blood leukocytes of patients with infectious mononucleosis, subacute myelo-optico-neuropathy (SMON), acute myelogenous leukemia and chronic lymphatic leukemia. All the cell lines grow in suspension and mostly consist of lymphoblastoid cells regardless of the cell source and clinical status of the donors. A few percentage of Epstein-Barr virus (EBV) antigen-positive cells were detected by the immunofluorescence method in all the cell lines. These cell lines have maintained karyotypes of predominantly normal diploid modes. It is suggested that the origin of these cell lines may be certain lymphocytes in peripheral leukocytes. From the present study, a following hypothesis may be offered on the establishment of the lymphoblastoid cell lines. It is conceivable that EBV which is harbored in vivo in lymphocytes might be activated and replicate in the early stage of leukocyte culture. The virus would, thereafter, exert an antigenic stimulation on some of the lymphocytes and consequently they would undergo blastoid transformation, yielding self-sustaining cell lines.
en-copyright=
kn-copyright=

en-aut-name=HasegawaHarumi
en-aut-sei=Hasegawa
en-aut-mei=Harumi
kn-aut-name=長谷川晴巳
kn-aut-sei=長谷川
kn-aut-mei=晴巳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
END

start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=7-8
article-no=
start-page=247
end-page=258
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=19710830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cytological Studies on the Endocrine Cells in the Mucosa of Human Stomach　Part �U. Histochemical and Ultrastructual Studies on the Endocrine Cells in the Pathological Antral Mucosa of Human Stomach
kn-title=ヒトの胃の内分泌細胞の細胞学的研究 第�U編 病的状態の胃前庭部粘膜における内分泌細胞の組織化学的・電子顕微鏡的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Normal and pathological antral mucosa (gastric ulcer, gastroduodenal ulcer, duodenal ulcer, gastric cancer, giant rugae, gastritis chronica and gastric polyp) were examined histochemically and electron microscopically. 1) It was clarified that the Ec-cells are observed only in the mucosa with intestinal metaplasia, and never in the normal mucosa. We tentatively classified the Ec-cells into two types; Ec-�T-cell and Ec-�U-cell. The specific granules in the Ec-�T-cells are polymorphous and contain a dense core enclosed by a limiting membrane which fits either tightly or loosely. The Ec-�U-cells have electron dense and polymorphous granules but do not contain a dense core in the limiting membrane. The ratio of Ec-�T-cells to Ec-�U-cells in the antral mucosa with intestinal metaplasia seems to be almost equal in gastric ulcer but smaller in gastric cancer. 2) Cell type �W-cell in the normal antral mucosa has three kinds of granules; electron dense granules (100-200 mμ in diameter), granules (about 400 mμ in diameter) which have cloud-like or bubble-like substances in the limiting membrane, and granules which are empty-looking in the limiting membrane. In gastric ulcer cases, the �W-type cells were apt to be granulated but there were no increse in the number. On the contrary, in atrophic gastritis, the �W-type cells had low electron dense granules which were empty-looking in the limiting membrane.
en-copyright=
kn-copyright=

en-aut-name=NabeyamaAkira
en-aut-sei=Nabeyama
en-aut-mei=Akira
kn-aut-name=鍋山晃
kn-aut-sei=鍋山
kn-aut-mei=晃
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=7-8
article-no=
start-page=235
end-page=245
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=19710830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cytological Studies on the Endocrine Cells in the Mucosa of Human Stomach Part �T. Ultrastructual Classification of Endocrine Cells in the Normal Antral Mucosa of Human Stomanch
kn-title=ヒトの胃の内分泌細胞の細胞学的研究 第�T編 ヒトの正常胃前庭部粘膜にみられる内分泌細胞の電子顕微鏡的分類
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The endocrine cells in te normal antral mucosa of the human stomach were examined by the electron microscope. According to their fine structural characteristics, they were classified into the following five types. 1) Cell-type �U is triangular in shape. The granules are round and vary in diameter (300-600mμ) and in electron density. 2) Cell-type �V is triangular in form and has many grnules (130mμ in diameter) with high electron density. These granules are characterized by their uniform size and homogeneous appearance. 3) Cell-type �W contains a prominent endoplasmic reticulum in the supranuclear region. These kinds of granules are recognizable in the basal part: smaller ones (100-200mμ), which are dense, larger ones (400mμ) which are pale and another larger ones (400mμ) which are empty-looking. 4) Cell-type �Xis contact with the glandular lumen and contains numerous secretory granules with various densities. 5) Cell-type �Y is oval in shape and characterized by small granules (100-150mμ) with moderate density, localized in the basal region. This cell type seems to have some features of an immature endocrine cells.
en-copyright=
kn-copyright=

en-aut-name=NabeyamaAkira
en-aut-sei=Nabeyama
en-aut-mei=Akira
kn-aut-name=鍋山晃
kn-aut-sei=鍋山
kn-aut-mei=晃
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=85
cd-vols=
no-issue=7-8
article-no=
start-page=373
end-page=385
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1973
dt-pub=19730830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Mechanism of Cortical Synchronized Activities with Special Reference to the Ventrolateral Thalamic Nucleus
kn-title=大脳皮質電気活動の同期化における視床腹外側核の関与について-ヒトとネコにおける電気生理学的研究-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Spindle-like afterdischarges evoked by stimulation of ventrolateral thalamic nucleus and spontaneous spindle waves were analized to investigate the electrophysiological mechanism of cortical synchronized activities in man as well as in cat. In man, three positive and three negative waves, namely �T-P, �T-N, �U-P, �U-N, �V-P and �V-N, were observed as cortical evoked responses after single stimulation of the ventrolateral thalamic nucleus. And �W-P and �W-N were observed after the stronger stimulation which could provoke augmenting response with the repetitive volley. Later components of evoked cortical responses were investigated in cat immobilized under local anesthasia. Recording electrole was located on the anterior sigmoid gyrus. As the intensity of the thalamic stimulation was increased, afterdischarges of the negative waves, which appeared with long latency (about 200 msec.), increased in number and developed into spindle-like pattern with notches on afterdischarges. The long latencied negative wave in cat and �W-N in man were considered to correspond to Lehtinen's "precursor of the evoked spindle activity". It has been already reported by Miyamoto that �W-N was supposed to play an important role in augmenting response in man. Close relationship was indicated between augmenting response and spindle-like afterdischarges. Futhermore, the similarities of the pattern between spindle-like afterdischarges following thalamic stimulation and spontaneous spindle waves in cat, and attenuation of ipsilateral spontaneous spindle waves after destruction of the ventrolateral thalamic nucleus in cat as well as in man were also observed. From these facts these cortical synchronized activities, namely AR, spindle-like afterdischarges and spontaneous spindle waves were considered to be brought by similar neuronal mechanism with some varieties of synchronization ascribed to arousal levels under influences of activities of the ventrolateral thalamic nucleus. On the other hand, spindle-like afterdischarges and spontaneous spindle waves in cat were analized for investigating their waxing and waning phenomena. Notches were observed on each waves. When the wave grew with maximal amplilude in a train of spindle, the notch of the wave became obscure. The phenomenon was considered that the notch was synchronized with the wave, forming maximal amplilude of the wave in a train of spindle. In other words, mechanism of this phenomenon was supposed to be explained as a beat of two rhythmic activities slightly different in frequency.
en-copyright=
kn-copyright=

en-aut-name=BeckHiroichi
en-aut-sei=Beck
en-aut-mei=Hiroichi
kn-aut-name=別宮博一
kn-aut-sei=別宮
kn-aut-mei=博一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学脳神経外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=85
cd-vols=
no-issue=5-6
article-no=
start-page=223
end-page=229
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1973
dt-pub=19730630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cytotoxic effect of sensitized apleen lymphocytes with SV40 and SV40 induced tumor on SV40 transformed cells
kn-title=SV40ウイルス及びSV40誘発腫瘍細胞により感作されたリンパ球のSV40変異ヒト胎児細胞に対する細胞障碍作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Sensitized lymphocytes have been demonstrated to inhibit tumor growth in vivo systems. In SV40-viral oncogenesis, some specified immunization with virns and with virus-induced tumors to the animals results in rejection of further transplantation of the tumor cells. To analyze these phenomena by our specially devised cytotoxicity test, the authors have studied cell mediated immunity for tumor specific transplantation antigen (TSTA) in SV40 viral oncogenesis. The results suggest that sensitized lymphocytes inhibit the growth of heterogenic SV40-transformed target cells as well as syngenic ones. And the lymphocytes from tumor-bearing animals have lower ability of the inhibition on the target cells, which may be explained that the lymphocytes in tumor bearing animals are under the condition of immunologically insufficient state.
en-copyright=
kn-copyright=

en-aut-name=EgusaKuniyuki
en-aut-sei=Egusa
en-aut-mei=Kuniyuki
kn-aut-name=江草国之
kn-aut-sei=江草
kn-aut-mei=国之
aut-affil-num=1
ORCID=

en-aut-name=SatoKeiko
en-aut-sei=Sato
en-aut-mei=Keiko
kn-aut-name=佐藤啓子
kn-aut-sei=佐藤
kn-aut-mei=啓子
aut-affil-num=2
ORCID=

en-aut-name=OdaTakuzo
en-aut-sei=Oda
en-aut-mei=Takuzo
kn-aut-name=小田琢三
kn-aut-sei=小田
kn-aut-mei=琢三
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌研生化学

affil-num=2
en-affil=
kn-affil=岡山大学医学部癌研生化学

affil-num=3
en-affil=
kn-affil=岡山大学医学部癌研生化学
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=1-2
article-no=
start-page=97
end-page=100
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Structure of the thoracic duct wall in human
kn-title=ヒトの胸管壁の構造について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the human thoracic duct wall the direction and the ascending angle of the smooth muscle cells are not necessarily fixed according to the site, but as a rule the smooth muscle cells of the interior layer of the tunica media ascend longitudinally at about 80° with their origin at the internal elastic membrane and connect to the circular muscle of tunica media that ascends at angle of about 10° and terminates at the external elastic membrane. At the exterior side of tunica media it becomes often longitudinal and sometimes it forms the exterior layer. The smooth muscle cells which connect the middle layer and exterior layer from the interior layer run in a specific arc line. In the case where a pair of valves cover the thoracic wall, at the site between the two valves there can be observed no longitudinal muscle of the interior layer. Generally the internal elastic membrane is incomplete, and often it forms longitudinal networks, but there is sometimes the case where morphologically it forms a well arranged internal elastic membrane.
en-copyright=
kn-copyright=

en-aut-name=SuwaKiichi
en-aut-sei=Suwa
en-aut-mei=Kiichi
kn-aut-name=諏訪喜一
kn-aut-sei=諏訪
kn-aut-mei=喜一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一解剖学教室
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=11-12
article-no=
start-page=1023
end-page=1032
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1975
dt-pub=19751230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=�U. Histological Studies on Experimental Allergic Hepatitis with Appraisal of Mononuclear Cells in its Development
kn-title=実験的アレルギー性肝炎の研究 第2編 同種肝抽出液感作リンパ球の移入による肝の組織変化
en-subtitle=
kn-subtitle=
en-abstract=In an attempt to evaluate the significance of mononuclear cells in the experimental allergic hepatitis which was previously studied, lymphocytes from inbred strain C(57) BL mice with the hepatitis was passively transfered into x-ray irradiated isologous mice. Early histological changes in the liver of the recipient mice consisted of an extensive coagulation necrosis on the 2nd or 3rd day after the transfer, and delayed changes occurring on the 7th to 10th post-transfer day included a marked infiltration of mononuclear cells in the portal areas, various types of liver cell necrosis and degeneration, a mononuclear cell infiltration in the sinusoid as well as an activation of the Kupffer cells as compared with control groups. These histological changes, however, were transient and subsided in 2 to 3 weeks post to the transfer of the cells. There was no tendency to the development of a feature of chronic hepatitis. The present experiment indicated that the passive transfer of sensitized lymphocytes obtained from mice with the experimental allergic hepatitis made by the previous experiment produced an allergic hepatitis comprising a coagulation necrosis and others in isologous mice, but this hepatitic change was transient and by no means transformed to a chronic status similar to a human chronic hepatitis as in the previous experiment.
kn-abstract=ヒトの肝炎の進展,慢性化の過程において,肝のグリソン鞘に浸潤している単核細胞がいかなる役割を果しているかを究明する一つの試みとして, complete Freund's adjuvant添加同種肝抗原でC57Blマウスを長期感作して実験的アレルギー性肝炎を作成し,感作C57Blマウスの脾およびリンパ節より感作リンパ球を分離し,レントゲン全身照射後の同系マウスに移入し,受動転嫁実験を実施した.その結果,対照群に比して,39例中15例に肝の組織変化を認めた.そのうち,早期すなわち移入後2〜3日目に発生した広範な凝固壊死を14例中3例に,やゝ遅れた時期すなわち移入後5〜8日目に発生したpiecemeal necrosisを主体とする変化を25例中2例に認め,それらの変化は感作リンパ球による肝細胞性壊死であることを強く示唆した.以上の肝の組織変化はヒトのウイルス性肝炎の組織所見に類似しており, B型肝炎発症における主要因の1つ,すなわちHB抗原感作リンパ球の果す意義にも関連して重要な実験成績であると考えた.
en-copyright=
kn-copyright=

en-aut-name=HirataHiroaki
en-aut-sei=Hirata
en-aut-mei=Hiroaki
kn-aut-name=平田弘昭
kn-aut-sei=平田
kn-aut-mei=弘昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=11-12
article-no=
start-page=1009
end-page=1021
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1975
dt-pub=19751230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=�T. Histological Studies on Experimental Hepatitis after Sensitization with Homologous Liver Extract
kn-title=実験的アレルギー性肝炎の研究 第1編 AKRマウス肝抽出液によるC57Blマウス長期感作後の組織学的変化
en-subtitle=
kn-subtitle=
en-abstract=In an attempt to evaluate histologically an allergic phenomenon involved in the development of chronic hepatitis in man, the inbred strain C57BL mice were sensitized for prolonged durations from 5 to 19 weeks with a homologous liver extract from AKR mice as well as with complete Freund's adjuvant. Histological changes in the liver of the sensitized mice immediately after the treatment comprised a marked round cell infiltration in the portal areas, piece-meal necrosis, various types of liver cell necrosis and degeneration, and an activation of the Kupffer cells as compared with control groups. These histological changes somewhat resembled the findings of chronic hepatitis in human liver disease, but they have greatly subsided in 5 weeks post to the last sensitization. It may be assumed on the basis of the present experiment that a persistent sensitization for a longer duration is necessitated for the establishment of a chronic murine hepatitis similar to a human chronic hepatitis.
kn-abstract=ヒトのウイルス性肝炎の発症および慢性化のアレルギー性機序を解明するための一手段として, AKR肝抽出液を抗原としてC57Blに長期感作を施行し,肝グリソン氏鞘内に著明な円形細胞浸潤,piecemeal necrosis,肝細胞壊死,星細胞の反応を作成しえたが,リンパ?胞の形成,肝グリソン氏鞘の結合織の増生は認められなかった.以上の組織変化は肝炎B抗原,すなわち,　hetero抗原とその抗体とのアレルギー機序によって生じると考えられるヒトのウイルス性肝炎の組織表現にかなり類似している.しかし,長期感作を中止し放置すると,組織変化は消褪した.
en-copyright=
kn-copyright=

en-aut-name=HirataHiroaki
en-aut-sei=Hirata
en-aut-mei=Hiroaki
kn-aut-name=平田弘昭
kn-aut-sei=平田
kn-aut-mei=弘昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=9-10
article-no=
start-page=893
end-page=899
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1975
dt-pub=19751030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Infection of Human Cultured Leukocytes with Murine Rauscher Leukemia Virus 2. Heterotransplantation of a Human Lymphoblastoid Cell Line Chronically Infected with Epstein-Barr Virus and Rauscher Leukemia Virus
kn-title=マウス白血病ウイルスのヒト培養白血球への感染に関する研究 第2編EBウイルスとC型ウイルスの重複持続感染系ヒトリンパ芽球様株細胞の異種移植
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An Epstein-Barr virus (EBV) -positive human lymphoblastoid cell line chronically infected with Rauscher murine leukemia virus (RLV) was transplanted into antilymphocyte serum (ALS)- treated newborn hamsters. Four of 10 hamsters transplanted developed nonlethal regressive tumors which continued to shed C-type virus. Lymphoblastoid cell cultures reestablished from the heterotransplanted tumor cells were positive for both EBV capsid and murine gs-1 antigens. In contrast, all the hamsters transplanted with its parent cell line without RLV infection succumbed to lethal progressive tumors. The RLV-infected cells were shown to have cell surface antigen that was not found in the noninfected cells. It is postulated that new membrane antigen associated with C-type virus infection provoked more immunologic reaction even in ALS-treated hamsters, accounting for the reduced tumorigenicity of the RLV-infected human leukocytes.
en-copyright=
kn-copyright=

en-aut-name=HayashiTakehiko
en-aut-sei=Hayashi
en-aut-mei=Takehiko
kn-aut-name=林建彦
kn-aut-sei=林
kn-aut-mei=建彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=5-6
article-no=
start-page=549
end-page=556
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1975
dt-pub=19750630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Infection of Human Cultured Leukocytes with Murine Rauscher Leukemia Virus �T. Persistent Dual Infection of Human Lymphoblastoid Cells with EB Virus and C Type Virus
kn-title=マウス白血病ウィルスのヒト培養白血球への感染に関する研究 第1編 ヒトリンパ芽球様株細胞におけるEBウイルスとC型ウイルスの重複持続感染の成立
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An EB virus-carrying lymphoblastoid cell line established from peripheral blood of a patient with SMON was super-infected in vitro with murine Rauscher leukemia virus. Since then, the cell line has been dually infected with both viruses for more than 1.5 years, as repeatedly demonstrated by the presence of herpes type virus particles and C type virus particles. The C type virus particles liberated from the human cultured leukocytes were no longer leukemogenic when inoculated into otherwise susceptible BALB/c mice, but this procedure rendered them considerably resistant to challenge infection with leukemogenic Rauscher leukemia virus that had been maintained by passage through BALB/c mice. The infectivity of the human cell-derived C type virus to other lymphoblastoid cell lines established from different patients and to primary BALB/c mouse embryo cells could not be demonstrated by the method employed. The implication of these findings is discussed in the light of possible viral etiology of human malignancy.
en-copyright=
kn-copyright=

en-aut-name=HayashiTakehiko
en-aut-sei=Hayashi
en-aut-mei=Takehiko
kn-aut-name=林建彦
kn-aut-sei=林
kn-aut-mei=建彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=フコース除去抗体のヒト末梢血中における抗体依存性細胞傷害（ADCC）活性誘導作用及びその機序に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IidaShigeru
en-aut-sei=Iida
en-aut-mei=Shigeru
kn-aut-name=飯田茂
kn-aut-sei=飯田
kn-aut-mei=茂
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=5-6
article-no=
start-page=629
end-page=639
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19780630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Human embryonic liver cell in culture Part �U.
kn-title=ヒト胎児肝細胞の培養 第2報
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the previous report, we dealt with the method and the culture of human embryonic liver cells, and its difficulties in establishing epithelial cell lines from normal human liver. HuL-4 cell strain was published as an epithelial cell strain in the previous paper. We examined the cell morphologically, histochemically, and the cellular localisation of albumin and AFP (α-fetoprotein) immunofluorescently. Chromosome of the cells and uptake of Indian ink into the cell were also undertaken. We also calculated the growth curve of the strain and analyzed the liver specific enzymes. The results are summarized as follows. 1). HuL-4 cell strain derived from human embryonic liver disclosed dominant epithelial cell growth than fibroblastic cells, and it continued to cultivate up to 24 passages in 758 days. 2). Direct immunofluorescence method for albumin and AFP failed to show any positive stain. 3). PAS staining of the cell revealed weak positive, and it was digested by diastase. PAP silver staining was negative, and the uptake of Indian ink into the cells was negative for up to 12 hours. 4). Chromosome analysis of the cell was normal (46 numbers, diploid) and no marker chromosomes were detected. 5). Hul-4 cell strain was epithelial morphologically, but it contained no liver specific enzymes.
en-copyright=
kn-copyright=

en-aut-name=ImaiHiromichi
en-aut-sei=Imai
en-aut-mei=Hiromichi
kn-aut-name=今井寛途
kn-aut-sei=今井
kn-aut-mei=寛途
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部付属癌源研究施設病理部
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒトデ・プロテインキナーゼCアイソフォームおよびCdc25プロテインホスファターゼに関する研究
kn-title=Studies of Starfish Protein Kinase C Isoforms and Cdc25 Protein Phosphatase
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MiyakeYasuo
en-aut-sei=Miyake
en-aut-mei=Yasuo
kn-aut-name=三宅康夫
kn-aut-sei=三宅
kn-aut-mei=康夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=可逆性不死化ヒト骨髄間葉系幹細胞を用いた骨再生の検討
kn-title=Bone Repair by Transplantation of hTERT-Immortalized Human Mesenchymal Stem Cells in Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakaharaHiroyuki
en-aut-sei=Nakahara
en-aut-mei=Hiroyuki
kn-aut-name=中原啓行
kn-aut-sei=中原
kn-aut-mei=啓行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=11-12
article-no=
start-page=1597
end-page=1607
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19771230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Enzymic studies of breast cancer Part 2. Influences of hormonal incubation of human breast cancer tissue on glycolytic enzymic activity
kn-title=乳癌の酵素活性に関する研究 第2編 ヒト乳腺組織の酵素活性ならびにヒト乳癌組織の酵素活性に及ぼすホルモンの影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Glycolytic enzyme activities of human breast cancer was studied on age, menopausal status, T, N, Stage and pathology in benign and malignant tumor. Influences on incubation with additional hormones also were studied. Mastopathy, benign tumor and breast cancer showed varied enzymic activity. High enzymic activity was observed in breast cancer tissue, but the enzymic activity was not paralleled with tumor size. Enzymic activity changed by incubation with additional hormones. Pre menopausal state, T(1), negative lymph node metastasis, Stage I tissues were elevated enzymic activity. Post menopausal state, T(3), positive lymph node metastasis, and Stage III tissues were decreased enzymic activity.
en-copyright=
kn-copyright=

en-aut-name=InoueMakoto
en-aut-sei=Inoue
en-aut-mei=Makoto
kn-aut-name=井上真
kn-aut-sei=井上
kn-aut-mei=真
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=3-4
article-no=
start-page=265
end-page=294
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19780430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Transmission and scanning electron microscopic studies on human chronic gastritis
kn-title=ヒトの慢性胃炎胃粘膜の電子顕微鏡的走査型電子顕微鏡的観察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Thirty-six cases of human atrophic chronic gastritis were observed by transmission and scanning electron microscope. Generally, in the surface and neck mucous cells, vacuole formations and swelling of mitochondria were occasionally observed. Although, increase of young parietal cells were frequently noted, ultrastructural changes were hardly seen in the cytoplasm and the nucleus of both the parietal cells and the chief cells. Intestinal metaplastic mucosa was found in almost all cases of antral mucosa and in half cases of corporal mucosa of chronic gastritis. In the SEM observation, the gastric mucosa and the intestinal metaplastic mucosa were clearly bordered. In TEM observations, all types of normal small intestinal cells were found in the intestinal metaplastic mucosa, and there were no ultrastructural differences between normal intestinal cells and intestinal metaplastic mucosa cells. It was interesting that enterochromaffin cells, which were scarce in normal gastric mucosa and numerous in small intestine, were frequently observed in intestinal metaplastic mucosa. In the three cases of chronic gastritis, the peculiar type cells which had both endocrine cells granules and mucous granules were found and their origins were discussed.
en-copyright=
kn-copyright=

en-aut-name=ImajoTamotsu
en-aut-sei=Imajo
en-aut-mei=Tamotsu
kn-aut-name=今城保
kn-aut-sei=今城
kn-aut-mei=保
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=9-10
article-no=
start-page=1329
end-page=1357
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19771030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A cytochemical study of the absorption of horseradish peroxidase through the human gastrointestinal tract
kn-title=ヒト消化管からのHorseradish Peroxidaseの吸収の細胞化学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using horseradish peroxidase (HRP) which serves as its own tracers, the absorption of intact macromolecules through the human gastrointestinal tracts was observed. In healthy volunteers, HRP was poured into the stomach, the duodenum, and the ileum through the gastric, duodenal and colonofiberscopes at several days interval. Twenty minutes after the injection, small samples of mucosa were removed. The tissues thus obtained were treated in the manner of Karnovsky and embedded in Epon and observed under an electron microscope. The absorption of HRP through the human small intestine and the intestinal metaplastic epithelia of the stomach was clearly demonstrated. Moreover, in intestinalized epithelium of the stomach, HRP was absorbed and transferred into the capillary lumen. These results indicated the posibility of absorption of macromolecules through the human gastrointestinal tract, which may be a cause of food-allergy and food poisoning. At the same time, it showed the effectiveness of oral administration of some enzyme-containing medicines. The absorption through the intestinal metaplastic epithelium was considered to be especially significant, because eaten proteins are promptly absorbed before digestion occurred.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoTeruo
en-aut-sei=Matsumoto
en-aut-mei=Teruo
kn-aut-name=松本昭郎
kn-aut-sei=松本
kn-aut-mei=昭郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=9-10
article-no=
start-page=1221
end-page=1243
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19771030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A cytological study on the caveolated cells of the rat and the human digestive organs
kn-title=ラットおよびヒトにおけるcaveolated cellの細胞学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Firstly, the ultrastructure of the caveolated cells on the rat bile duct were examined by a transmission and a scanning electron microscope. Next, the author seeked whether caveolated cells were present or not in the human digestive organs. Lastly, functional study of the caveolated cells on the rat bile duct were investigated using horseradish peroxidase and pilocarpine. Then the facts mentioned below were clarified. 1) Caveolated cells in the rat bile duct were found most densely at the divelticulum-like recesses but on the luminal surface except this recesses caveolated cells were found partly densely and partly sparsely. 2) On the rat, the straight filaments of the caveolated cells of the bile duct were less developed than that of the digestive tract, but circular filaments were more developed than that of the digestive tract. 3) The apical vesicles of the caveolated cells were revealed to have no communication to outer lumen of these cells using lanthanum as a tracer. 4) The caveolated cell-like cells were found in the mucosa of a human colon. But these cells could not be identified clearly with caveolated cells. Because the vesicles were scanty and small in size and the inner substance was relatively electron opaque. 5) After intraluminal injection of peroxidase into ligated segments of bile duct, the marker was found within the apical vesicles. But it was not uncertain whether pre-existing apical vesicles had taken up the marker or vesicles containing the marker were formed newly by pinocytosis. 6) After intraperitoneal injection of pilocarpine, the supranuclear vesicles began to expand and the vesicles with granules moved toward the free surface suggesting eruption or diacrine secretion. And frequently apocrine secretion was also observed. In conclusion, the author supposes that caveolated cell may have both absorptive and secretory functions and this type cells may present in human digestive tract.
en-copyright=
kn-copyright=

en-aut-name=OkudaTakehiko
en-aut-sei=Okuda
en-aut-mei=Takehiko
kn-aut-name=奥田武彦
kn-aut-sei=奥田
kn-aut-mei=武彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=7-8
article-no=
start-page=1035
end-page=1047
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19770830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the distribution of lymphocyte subpopulations in human tissues Part 2. Identification of lymphocyte subpopulations infiltrating in autoimmune diseases
kn-title=ヒト組織内リンパ球subpopulationの分布に関する研究 第2編 臓器内浸潤リンパ球subpopulahonの分布-自己免疫性疾患を中心として.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The lymphocyte subpopulations were detected in the target organs obtained from various autoimmune disorders on the tissue cryosections. Thymus-derived lymphocytes (T cells) and bone marrow-derived lymphocytes (B cells) were detected by rosette formation with sheep erythrocytes (E) or with sheep erythrocytes coated with antibody and complement (EAC) respectively. Almost all infiltrating lymphocytes in the salivery glands in patients with Sjogren's syndrome were identified as B cells and T cells were detected only along the ducts. In Hashimoto's thyroiditis, infiltrating lymphocytes with the lymph follicles in the thyroid gland were mostly B cells whereas T cells localized as surrounded the thyroid follicles. T cells would not be detected in the spleen sections obtained from the patients with hypoplastic anemia at all. The white pulp was constituted by B cells, and the mononuclear cells in the red pulp might be macrophages of which these cell surfaces had IgG-Fc receptors. The lymph follicles of the thymus in a patient with myasthenia gravis complicated with thymoma was demonstrated to be formed with B cells. Therefore, it could be concluded that B cells were predominant lymphocytes in the target organs, while T cells localized in situ developing the autoimmune reactions in various autoimmune diseases.
en-copyright=
kn-copyright=

en-aut-name=KoriyamaKenji
en-aut-sei=Koriyama
en-aut-mei=Kenji
kn-aut-name=郡山健治
kn-aut-sei=郡山
kn-aut-mei=健治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=7-8
article-no=
start-page=1021
end-page=1033
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19770830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the distribution of lymphocyte subpopulations in human tissues Part 1. Fundamental studies on identification of lymphocyte subpopulations and their application to lymphoid organs
kn-title=ヒト組織内リンパ球Subpopulationの分布に関する研究 第l編 組織内リンパ球subpopulationの分布同定法の基礎的検討および各リンパ組織におけるその分布
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Thymus-derived lymphocytes (T-cells) and bone marrow-derived lymphocytes (B-cells) in the cryosection of human tissues were identified either by rosette formation with sheep erythrocytes (E) or with erythrocytes sensitized with antibody and complement (EAC), respectively. Invariable and stable reaction was obtained in EAC rosettes of the tissue lymphocytes while E binding of them was rather unstable. E could be adhered in the thymus sections which were obtained from normal infants during open heart surgery, but EAC did not bind to them at all. It was confirmed that B-cells located mostly in the lymph follicles of the lymph nodes as well as the palatine tonsils and T-cells were present predominantly in the paracortical area and interfollicular region. B-cells in the germinal centers would generally have more activated C(3) receptors than those of the mantle zones. In addition, B-cells of the lymph follicles both in the lymph nodes and in the palatine tonsils could be also detected utilizing the membrane immunofluorescence technique. The proportion of T and B-cells distribution in the lymphoid tissue was well correlated with that obtained on free cell suspension technique.Therefore, it could be concluded that T and B lymphocytes were able to identify respectively even in tissue level.
en-copyright=
kn-copyright=

en-aut-name=KoriyamaKenji
en-aut-sei=Koriyama
en-aut-mei=Kenji
kn-aut-name=郡山健治
kn-aut-sei=郡山
kn-aut-mei=健治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=7-8
article-no=
start-page=949
end-page=953
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19770830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Pattern of immunoglobulin production in human lymphoblastoid cell lines
kn-title=ヒトリンパ芽球様細胞株における免疫グロブリン産生の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Membrane-associated (M-Ig) and cytoplasmic immunoglobulins (C-Ig) of 4 human lymphoblastoid cell lines and 3 clones isolated from one of them were examined by immunofluorescence test. It was found that individual cells produced only a single type of light chain components and one or more types of heavy chain components of Ig. There was no specific correlation between the Ig types of M-Ig and C-Ig.
en-copyright=
kn-copyright=

en-aut-name=AkagiTadaatsu
en-aut-sei=Akagi
en-aut-mei=Tadaatsu
kn-aut-name=赤木忠厚
kn-aut-sei=赤木
kn-aut-mei=忠厚
aut-affil-num=1
ORCID=

en-aut-name=MatsudaYuzo
en-aut-sei=Matsuda
en-aut-mei=Yuzo
kn-aut-name=松田勇蔵
kn-aut-sei=松田
kn-aut-mei=勇蔵
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=高知県立中央病院:癌研究所

affil-num=2
en-affil=
kn-affil=岡山大学医学部:第2内科
END

start-ver=1.4
cd-journal=joma
no-vol=92
cd-vols=
no-issue=11-12
article-no=
start-page=1131
end-page=1139
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1980
dt-pub=19801230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Monocytes in patients with malignant diseases Part 2
kn-title=ヒト末梢血単球の検討 第2編 悪性腫瘍患者における末梢血単球数とlysosomal enzymeの検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Absolute peripheral blood monocyte counts and the β-galactosidase activity of monocytes were studied in 60 patients with lung cancer, 20 with malignant lymphoma, 17 with other malignant diseases, 13 with sarcoidosis and 28 normal individuals. The monocyte count was 296.3±176.8/cmm in lung cancer, 315.6±160.0/cmm in malignant lymphoma, 217.8±89.6/cmm in sarcoidosis, and 298.6±144.1/cmm in normal individuals. Although there was no significant differences in the monocyte count of malignant and non-malignant diseases, all patients with lung cancer or malignant lymphoma had monocyte counts less than 100/cmm. In patients with lung cancer and malignant lymphoma, there was no significant differences in histological types or clinical stages. The monocyte count in lung cancer patients treated with streptococcal agent OK-432 was elevated to 484.9±269.0/cmm, as compared with 315.5±107.7/cmm before administration. A nadir of monocyte counts was found at one week after combination chemotherapy but recovery to normal value was observed by 3 weeks after. On the other hand, white blood cell counts reached a nadir 2 weeks after chemotherapy and recovered by 4 weeks after. The percentages of β-galactosidase positive monocytes were 21.5±11.5% in patients with lung cancer, 20.1±7.5% in malignant lymphomas, 19.1±6.8% in other malignant diseases and 25.3±12.4% in normal individuals. There was no significant differences in β-galactosidase activity related to histological types or clinical stages of patients with lung cancer and malignant lymphoma. No changes in β-galactosidase activity were found between before and after combination chemotherapy.
en-copyright=
kn-copyright=

en-aut-name=TakasugiKenta
en-aut-sei=Takasugi
en-aut-mei=Kenta
kn-aut-name=高杉健太
kn-aut-sei=高杉
kn-aut-mei=健太
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第二内科学教室
en-keyword=悪性腫瘍
kn-keyword=悪性腫瘍
en-keyword=末梢血単球数
kn-keyword=末梢血単球数
en-keyword=β-ガラクトシダーゼ活性
kn-keyword=β-ガラクトシダーゼ活性
en-keyword=ライゾゾーム酵素活性
kn-keyword=ライゾゾーム酵素活性
END

start-ver=1.4
cd-journal=joma
no-vol=92
cd-vols=
no-issue=11-12
article-no=
start-page=1123
end-page=1130
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1980
dt-pub=19801230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Isolation of monocytes in human peripheral blood Part 1 by discontinuous density gradient
kn-title=ヒト末梢血単球の検討 第1編 ヒト末梢血単球の分離と同定
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The isolation of monocytes in human peripheral blood by discontinuous density gradients was studied. Discontinuous density gradients were obtained by successive layering of bovine serum albumins into three layers in 10ml glass tubes. Buffy coat cells were layered on top of a gradient and centrifuged under various conditions of centrifugation. Optimal isolation was achieved by centrifugation on a three layer of 35-32-28% bovine serum albumin at 490g for 60 minutes. The purity, yield and recovery of monocytes at the interface between 35% and 32% bovine serum albumin were 54.0%, 7.0×10(5) and 22.0% respectively. After centrifugation on Conray-Ficoll mixtures, the interface fraction containing lymphocytes was removed and the bottom fraction containing monocytes and other cells was centrifuged under various condition. The optimal condition was on a three layer of 35-32-28% bovine serum albumin at 400g for 40 minutes. The purity of monocytes by this method increased to 75% but the yield and recovery declined to 2.5×10(5) and 4.5% respectively. From these data I concluded that isolation of monocytes from blood only on density gradients was difficult because of a partial overlap between monocytes and lymphocytes in the density distribution profiles.
en-copyright=
kn-copyright=

en-aut-name=TakasugiKenta
en-aut-sei=Takasugi
en-aut-mei=Kenta
kn-aut-name=高杉健太
kn-aut-sei=高杉
kn-aut-mei=健太
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科教室
en-keyword=末梢血単球の分離
kn-keyword=末梢血単球の分離
en-keyword=比重遠沈法による末梢血単球の分離
kn-keyword=比重遠沈法による末梢血単球の分離
en-keyword=牛アルブミンによる末梢血単球の分離
kn-keyword=牛アルブミンによる末梢血単球の分離
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=5-6
article-no=
start-page=679
end-page=691
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19770630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A new rapid assay method of collagenase activity and its clinical applications Part 2. Determination of collagenase activity in human leucocytes and synovial fluids by the newly developed method
kn-title=コラゲナーゼ活性の新しい迅速測定法の検討とその応用 第2編 ヒト好中球および関節液コラゲナーゼ活性測定への溶液法の応用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A newly developed collagenase assay method using (14)C-labeled soluble collagen as substrate has been applied to the determination of collagenase activity in human leucocytes and synovial fluids. The results indicated that collagenase activity in the both samples could be measured by this method as observed with tadpole collagenase, except that 35 % dioxane was preferable for the extraction of the enzyme digestion products in the case of synovial fluids. Collagenase activity determined by the present method was well correlated with that obtained by the conventional assay method using reconstituted collagen fiblils as substrate (r=0.963 and 0.829 (p<0.01) respectively). In preliminary experiments with leucocytes from patients with diabetes mellitus (DM), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), it was observed that collagenase activity in leucocytes increased significantly in SLE and from some patients with RA, while no appreciable differences were observed in diabetics, compared to that in normals. In synovial fluids from patients with RA and osteoarthritis (OA), the accumulation of large amount of inactive (latent) form of collagenase was demonstrated by the treatment of synovial fluids with 3M KI. And it was varied significantly in one patient at different time while no appreciable amount of the active form was observed during the period.
en-copyright=
kn-copyright=

en-aut-name=TeratoKuniaki
en-aut-sei=Terato
en-aut-mei=Kuniaki
kn-aut-name=寺戸国昭
kn-aut-sei=寺戸
kn-aut-mei=国昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第3内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=5-6
article-no=
start-page=609
end-page=613
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19770630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Identification of tyramine and octopamine in human serum by mass fragmentography
kn-title=Mass fragmentographyによるヒト血清中tyramineおよびoctopamineの同定
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Tyramine and octopamine were identified by means of mass fragmentography in human serum. The peaks identical to the retention time of tyramine and octopamine were found on gaschromatogram obtained from serum sample. Two fragments, M/e 316 and M/e 303 in mass spectrum of tyramine were used in tyramine identification, and M/e 528 and M/e 515 were used in octopamine identification. As the experimental results, the ratio M/e 303 : M/e 316 of the sample was identical to that of authentic tyramine, and ratio M/e 515 : M/e 528 was identical to that of authentic octopamine. These results suggest that tyramine and octopamine could exist in human serum.
en-copyright=
kn-copyright=

en-aut-name=OkitaMisako
en-aut-sei=Okita
en-aut-mei=Misako
kn-aut-name=沖田美佐子
kn-aut-sei=沖田
kn-aut-mei=美佐子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳代謝研究施設病態生化学部門
END