start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=6
article-no=
start-page=2485
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250311
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Vesicular Glutamate Transporter 3 Is Involved in Glutamatergic Signalling in Podocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Glomerular podocytes act as a part of the filtration barrier in the kidney. The activity of this filter is regulated by ionotropic and metabotropic glutamate receptors. Adjacent podocytes can potentially release glutamate into the intercellular space; however, little is known about how podocytes release glutamate. Here, we demonstrated vesicular glutamate transporter 3 (VGLUT3)-dependent glutamate release from podocytes. Immunofluorescence analysis revealed that rat glomerular podocytes and an immortal mouse podocyte cell line (MPC) express VGLUT1 and VGLUT3. Consistent with this finding, quantitative RT-PCR revealed the expression of VGLUT1 and VGLUT3 mRNA in undifferentiated and differentiated MPCs. In addition, the exocytotic proteins vesicle-associated membrane protein 2, synapsin 1, and synaptophysin 1 were present in punctate patterns and colocalized with VGLUT3 in MPCs. Interestingly, approximately 30% of VGLUT3 colocalized with VGLUT1. By immunoelectron microscopy, VGLUT3 was often observed around clear vesicle-like structures in differentiated MPCs. Differentiated MPCs released glutamate following depolarization with high potassium levels and after stimulation with the muscarinic agonist pilocarpine. The depletion of VGLUT3 in MPCs by RNA interference reduced depolarization-dependent glutamate release. These results strongly suggest that VGLUT3 is involved in glutamatergic signalling in podocytes and may be a new drug target for various kidney diseases.
en-copyright=
kn-copyright=

en-aut-name=NishiiNaoko
en-aut-sei=Nishii
en-aut-mei=Naoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawaiTomoko
en-aut-sei=Kawai
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YasuokaHiroki
en-aut-sei=Yasuoka
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AbeTadashi
en-aut-sei=Abe
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TatsumiNanami
en-aut-sei=Tatsumi
en-aut-mei=Nanami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HaradaYuika
en-aut-sei=Harada
en-aut-mei=Yuika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiyajiTakaaki
en-aut-sei=Miyaji
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=LiShunai
en-aut-sei=Li
en-aut-mei=Shunai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TsukanoMoemi
en-aut-sei=Tsukano
en-aut-mei=Moemi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=WatanabeMasami
en-aut-sei=Watanabe
en-aut-mei=Masami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OgawaDaisuke
en-aut-sei=Ogawa
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TakeiKohji
en-aut-sei=Takei
en-aut-mei=Kohji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=YamadaHiroshi
en-aut-sei=Yamada
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Genomics and Proteomics, Advanced Science Research Center, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Genomics and Proteomics, Advanced Science Research Center, Okayama University
kn-affil=

affil-num=8
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Central Research Laboratory, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=VGLUT3
kn-keyword=VGLUT3
en-keyword=glutamate
kn-keyword=glutamate
en-keyword=podocyte
kn-keyword=podocyte
en-keyword=glutamatergic transmission
kn-keyword=glutamatergic transmission
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=
article-no=
start-page=113
end-page=120
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202503
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=In-house lawyers working in non-legal departments
kn-title=非法務部門で働くインハウス－内部監査、監査役スタッフ業務の魅力－
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MinamiYuko
en-aut-sei=Minami
en-aut-mei=Yuko
kn-aut-name=南裕子
kn-aut-sei=南
kn-aut-mei=裕子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=積水化学工業株式会社　監査室
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=19
end-page=52
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Mineralogy and geochemistry of magnetite-garnet bearing skarn deposits surrounding iron-smelting sites in the Kibi region of Japan
kn-title=吉備製鉄遺跡周辺地域の磁鉄鉱ざくろ石スカルン鉄鉱石の鉱物学的・地球化学的特徴
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We conducted mineralogical and geochemical analysis of ore samples taken from locations surrounding the Jinmu, Sanpō, and Kōmoto mines in order to determine the source of iron ore uncovered from archaeological sites. The mineral composition of the magnetite-garnet bearing skarn deposits varies from mine to mine: while clinopyroxene and amphibole are present in the Jinmu and Sanpō samples, only a small amount of clinopyroxene occurs in the Kōmoto samples. The chemical compositions of magnetite and garnet are distinctive for each mine. Among the trace elements contained in the magnetite, Mg and Mn tend to be higher in the Kōmoto samples, Ti in the Jinmu samples, and Ca and Si in the Sanpō samples. The garnet from all the mines is andradite, but while the Kōmoto samples contain almost no Al, it is present in the Jinmu and Sanpō samples. Although samples were taken from a limited number of mine areas (three), our analysis provides an index for comparison with iron ore uncovered from archaeological sites, which will aid in provenance determination.
en-copyright=
kn-copyright=

en-aut-name=TAKECHIYasushi
en-aut-sei=TAKECHI
en-aut-mei=Yasushi
kn-aut-name=武智泰史
kn-aut-sei=武智
kn-aut-mei=泰史
aut-affil-num=1
ORCID=

en-aut-name=NAKAMURADaisuke
en-aut-sei=NAKAMURA
en-aut-mei=Daisuke
kn-aut-name=中村大輔
kn-aut-sei=中村
kn-aut-mei=大輔
aut-affil-num=2
ORCID=

en-aut-name=SUZUKIShigeyuki
en-aut-sei=SUZUKI
en-aut-mei=Shigeyuki
kn-aut-name=鈴木茂之
kn-aut-sei=鈴木
kn-aut-mei=茂之
aut-affil-num=3
ORCID=

en-aut-name=RYANJoseph
en-aut-sei=RYAN
en-aut-mei=Joseph
kn-aut-name=ライアンジョセフ
kn-aut-sei=ライアン
kn-aut-mei=ジョセフ
aut-affil-num=4
ORCID=

en-aut-name=UWAGAKITakeshi
en-aut-sei=UWAGAKI
en-aut-mei=Takeshi
kn-aut-name=上栫武
kn-aut-sei=上栫
kn-aut-mei=武
aut-affil-num=5
ORCID=

en-aut-name=NAGAHARAMasato
en-aut-sei=NAGAHARA
en-aut-mei=Masato
kn-aut-name=長原正人
kn-aut-sei=長原
kn-aut-mei=正人
aut-affil-num=6
ORCID=

en-aut-name=YOSHIEYuta
en-aut-sei=YOSHIE
en-aut-mei=Yuta
kn-aut-name=吉江雄太
kn-aut-sei=吉江
kn-aut-mei=雄太
aut-affil-num=7
ORCID=

en-aut-name=IKEHATAKei
en-aut-sei=IKEHATA
en-aut-mei=Kei
kn-aut-name=池端慶
kn-aut-sei=池端
kn-aut-mei=慶
aut-affil-num=8
ORCID=

en-aut-name=KIMURAOsamu
en-aut-sei=KIMURA
en-aut-mei=Osamu
kn-aut-name=木村理
kn-aut-sei=木村
kn-aut-mei=理
aut-affil-num=9
ORCID=

en-aut-name=HATTORIRyoichi
en-aut-sei=HATTORI
en-aut-mei=Ryoichi
kn-aut-name=服部亮一
kn-aut-sei=服部
kn-aut-mei=亮一
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Kurashiki Museum of Natural History
kn-affil=

affil-num=2
en-affil=Okayama University, Department of Earth Sciences
kn-affil=

affil-num=3
en-affil=Okayama University, Department of Earth Sciences
kn-affil=

affil-num=4
en-affil=Okayama University, Research Institute for the Dynamics of Civilizations
kn-affil=

affil-num=5
en-affil=Okayama Prefectural Board of Education
kn-affil=

affil-num=6
en-affil=The Historical Study Group of Mining and Metallurgy of Japan
kn-affil=

affil-num=7
en-affil=Mitsui Mining & Smelting Co., Ltd.
kn-affil=

affil-num=8
en-affil=University of Tsukuba, Faculty of Life and Environmental Sciences
kn-affil=

affil-num=9
en-affil=Okayama University, Research Institute for the Dynamics of Civilizations
kn-affil=

affil-num=10
en-affil=Osaka University, Graduate School of Humanities
kn-affil=
en-keyword=Iron-smithing sites
kn-keyword=Iron-smithing sites
en-keyword=skarn deposits
kn-keyword=skarn deposits
en-keyword=mineral composition of ore
kn-keyword=mineral composition of ore
en-keyword=geochemical analysis
kn-keyword=geochemical analysis
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=16
article-no=
start-page=1373
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240817
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Synaptopodin 2-like protein (SYNPO2L) is localized in the sarcomere of cardiomyocytes and is involved in heart morphogenesis. However, the molecular function of SYNPO2L in the heart is not fully understood. We investigated the interaction of SYNPO2L with sarcomeric alpha-actinin and actin filaments in cultured mouse cardiomyocytes. Immunofluorescence studies showed that SYNPO2L colocalized with alpha-actinin and actin filaments at the Z-discs of the sarcomere. Recombinant SYNPO2La or SYNPO2Lb caused a bundling of the actin filaments in the absence of alpha-actinin and enhanced the alpha-actinin-dependent formation of actin bundles. In addition, high-speed atomic force microscopy revealed that SYNPO2La directly bound to alpha-actinin via its globular ends. The interaction between alpha-actinin and SYNPO2La fixed the movements of the two proteins on the actin filaments. These results strongly suggest that SYNPO2L cooperates with alpha-actinin during actin bundle formation to facilitate sarcomere formation and maintenance.
en-copyright=
kn-copyright=

en-aut-name=YamadaHiroshi
en-aut-sei=Yamada
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OsakaHirona
en-aut-sei=Osaka
en-aut-mei=Hirona
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TatsumiNanami
en-aut-sei=Tatsumi
en-aut-mei=Nanami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ArakiMiu
en-aut-sei=Araki
en-aut-mei=Miu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AbeTadashi
en-aut-sei=Abe
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KaiharaKeiko
en-aut-sei=Kaihara
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakahashiKen
en-aut-sei=Takahashi
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakashimaEizo
en-aut-sei=Takashima
en-aut-mei=Eizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=UchihashiTakayuki
en-aut-sei=Uchihashi
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NaruseKeiji
en-aut-sei=Naruse
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=TakeiKohji
en-aut-sei=Takei
en-aut-mei=Kohji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Science, Nagoya University
kn-affil=

affil-num=3
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Division of Malaria Research, Proteo-Science Center, Ehime University
kn-affil=

affil-num=9
en-affil=Graduate School of Science, Nagoya University
kn-affil=

affil-num=10
en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=SYNPO2L
kn-keyword=SYNPO2L
en-keyword=actinin
kn-keyword=actinin
en-keyword=actin
kn-keyword=actin
en-keyword=sarcomere
kn-keyword=sarcomere
en-keyword=cardiomyocyte
kn-keyword=cardiomyocyte
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=二酸化炭素を化学原料に用いる化学物質のワンポット合成
kn-title=One-Pot Synthesis of Chemicals Using CO2 as Chemical Feedstock
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NAKAOKAKoichi
en-aut-sei=NAKAOKA
en-aut-mei=Koichi
kn-aut-name=中岡弘一
kn-aut-sei=中岡
kn-aut-mei=弘一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama university
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=IRTA1及びMNDAの免疫組織化学が胃MALTリンパ腫と慢性胃炎/反応性リンパ過形成の鑑別において有用である
kn-title=Immunohistochemistry for IRTA1 and MNDA helps differentiate gastric MALT lymphoma from chronic gastritis/reactive lymphocyte hyperplasia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AYADAYoshiyuki
en-aut-sei=AYADA
en-aut-mei=Yoshiyuki
kn-aut-name=綾田善行
kn-aut-sei=綾田
kn-aut-mei=善行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=胃・大腸がんに対する初回化学療法中の亜鉛欠乏症状に関する前向き観察研究
kn-title=Prospective observational study of zinc deficiency symptoms during first-line chemotherapy for gastric and colorectal cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SAKAGUCHIChihiro
en-aut-sei=SAKAGUCHI
en-aut-mei=Chihiro
kn-aut-name=坂口智紘
kn-aut-sei=坂口
kn-aut-mei=智紘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Newsletter from Course for Prospective Museum Workers, Faculty of Letters, Okayama University
kn-title=学芸員課程 Newsletter 第14号
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=光本順
kn-aut-sei=光本
kn-aut-mei=順
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=阿部誠悟
kn-aut-sei=阿部
kn-aut-mei=誠悟
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=名村麻由子
kn-aut-sei=名村
kn-aut-mei=麻由子
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=若山聡良
kn-aut-sei=若山
kn-aut-mei=聡良
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松尾姫奈
kn-aut-sei=松尾
kn-aut-mei=姫奈
aut-affil-num=5
ORCID=

en-aut-name=
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en-title=Evaluator of adaptability of S. cerevisiae to grape juice using the oversxpression profiling ADOPT method
kn-title=過剰発現プロファイリングADOPT法を用いたS.cerevisiaeのワイン醸造用ブドウ果汁への適応性評価
en-subtitle=
kn-subtitle=
en-abstract=筆者らは最近，過剰発現プロファイリングADOPT 法を開発した．ADOPT 法では，出芽酵母Saccharomyces cerevisiae ゲノムのほとんどの遺伝子をそれぞれ過剰発現する酵母株を混合・競合培養し，その過程で濃縮されてきた株が過剰発現している遺伝子を体系的に同定する．さらに同定された遺伝子をたよりに，S. cerevisiae の与えられた条件での増殖に必要だが欠落しているボトルネック因子を明らかにできる．これまでの研究では，実験室で人為的に構築したストレス環境でのボトルネックの同定を行ってきたが，本研究では産業上のボトルネックを明らかにできるかをワイン醸造用のブドウ果汁を例として検証した．通常のワイン醸造に用いられる亜硫酸添加ブドウ果汁でのADOPT 実験は，亜硫酸ポンプSSU1とその転写因子FZF1の過剰発現株が強く濃縮された．SSU1機能の強化はワイン用酵母の馴養でも起きることが知られていることから，産業上のボトルネックを探索する際にもADOPT が有効であることが示された．一方，亜硫酸添加のないブドウ果汁ではADOPT で強く濃縮された遺伝子は見られず，ブドウ果汁はS. cerevisiae の増殖にとってボトルネックの少ないバランスのとれた培地であることが示唆された．
kn-abstract=The authors have recently developed the overexpression profiling ADOPT method. In the ADOPT method, yeast strains overexpressing most of the genes in the budding yeast Saccharomyces cerevisiae genome are mixed and competitively cultured, and the genes overexpressed in the enriched strains are systematically identified. Furthermore, the identified genes can be used to identify bottleneck factors that are necessary but lacking for growth of S. cerevisiae under given conditions. In our previous studies, we have identified bottlenecks in artificially created stress environments in the laboratory, but in this study, we used grape juice for winemaking as an example to see if industrial bottlenecks can be identified. ADOPT experiments with sulfite-added grape juice used in conventional winemaking resulted in a strong enrichment of strains overexpressing the sulfite pump SSU1 and its transcription factor FZF1. Since enhancement of SSU1 function is known to occur in wine yeast acclimation, ADOPT was also shown to be useful in the search for industrial bottlenecks. On the other hand, no genes were strongly enriched by ADOPT in grape juice without sulfite addition, suggesting that grape juice is a balanced medium with few bottlenecks for S. cerevisiae growth.
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en-keyword=yeast
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en-keyword=S. cerevisiae
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en-keyword=overexpression
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en-keyword=wine making
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END

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en-title=Leibniz on Matter: Focusing on Chemistry
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dt-pub-year=2023
dt-pub=20231201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 55th Annual Meeting of the Japanese Society for Matrix Biology and Medicine
kn-title=第55回日本結合組織学会学術大会開催報告
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OohashiToshitaka
en-aut-sei=Oohashi
en-aut-mei=Toshitaka
kn-aut-name=大橋俊孝
kn-aut-sei=大橋
kn-aut-mei=俊孝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Molecular Biology and Biochemistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学学術研究院医歯薬学域　分子医化学
END

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dt-pub-year=2023
dt-pub=20230925
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kn-subject=
en-title=
kn-title=化学療法を受ける大腸がん患者の手指に生じる末梢神経障害の特徴―横断的観察研究―
en-subtitle=
kn-subtitle=
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kn-abstract=
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kn-copyright=

en-aut-name=YASUDAChika
en-aut-sei=YASUDA
en-aut-mei=Chika
kn-aut-name=安田千香
kn-aut-sei=安田
kn-aut-mei=千香
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=岡山大学大学院保健学研究科
END

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dt-accepted=
dt-pub-year=2023
dt-pub=20230925
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en-subject=
kn-subject=
en-title=アルコールから乾燥調製した糖類アモルファスマトリクスの難水溶性薬剤の固体分散キャリアとしての応用とその物理化学的特性
kn-title=Application of amorphous sugar matrix dried from alcohol to solid dispersion of hydrophobic drug and its physicochemical characteristics
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TAKEDAKoji
en-aut-sei=TAKEDA
en-aut-mei=Koji
kn-aut-name=竹田昂司
kn-aut-sei=竹田
kn-aut-mei=昂司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama university
kn-affil=岡山大学大学院自然科学研究科
END

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dt-pub-year=2023
dt-pub=20230925
dt-online=
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en-subject=
kn-subject=
en-title=化学療法誘発性末梢神経障害モデルラットの前脛骨部筋膜におけるヒアルロン酸合成酵素およびヒアルロン酸含有細胞の減少
kn-title=Decreased expression of hyaluronan synthase and loss of hyaluronan-rich cells in the anterior tibial fascia of the rat model of chemotherapy-induced peripheral neuropathy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WANGRUILIN
en-aut-sei=WANG
en-aut-mei=RUILIN
kn-aut-name=王瑞林
kn-aut-sei=王
kn-aut-mei=瑞林
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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dt-pub-year=2023
dt-pub=20230925
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en-subject=
kn-subject=
en-title=臼蓋関節唇の血管内皮増殖因子および神経成長因子の発現は変形性股関節症の疼痛に直接関連する：免疫組織化学染色による検討
kn-title=Expression of Acetabular Labral Vascular Endothelial Growth Factor and Nerve Growth Factor Is Directly Associated with Hip Osteoarthritis Pain: Investigation by Immunohistochemical Staining
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SATOYoshihiro
en-aut-sei=SATO
en-aut-mei=Yoshihiro
kn-aut-name=佐藤嘉洋
kn-aut-sei=佐藤
kn-aut-mei=嘉洋
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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cd-journal=joma
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dt-pub-year=2005
dt-pub=20050930
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kn-subject=
en-title=グラム陰性菌における多剤排出ポンプの分子遺伝学的・生化学的解析
kn-title=Molecular genetic analysis and biochemical characterization of multidrug efflux pumps in Gram negative bacteria
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Anowara Begum
en-aut-sei=Anowara Begum
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
no-vol=135
cd-vols=
no-issue=2
article-no=
start-page=92
end-page=94
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dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Autophagy
kn-title=オートファジー
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakeiKohji
en-aut-sei=Takei
en-aut-mei=Kohji
kn-aut-name=竹居孝二
kn-aut-sei=竹居
kn-aut-mei=孝二
aut-affil-num=1
ORCID=

en-aut-name=YamadaHiroshi
en-aut-sei=Yamada
en-aut-mei=Hiroshi
kn-aut-name=山田浩司
kn-aut-sei=山田
kn-aut-mei=浩司
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Neurosience, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学学術研究院医歯薬学域　生化学

affil-num=2
en-affil=Department of Neurosience, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学学術研究院医歯薬学域　生化学
END

start-ver=1.4
cd-journal=joma
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dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=カーボンナノチューブ/デンドリマーハイブリッドによる水からの水素生成と生体イメージングのための光化学特性
kn-title=Photochemical properties of carbon nanotube/dendrimer hybrids for photocatalytic H2 evolution from water and biomedical imaging
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YAMAGAMIMasahiro
en-aut-sei=YAMAGAMI
en-aut-mei=Masahiro
kn-aut-name=山神将大
kn-aut-sei=山神
kn-aut-mei=将大
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
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dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=中央アナトリアにおける初期の鉄生産への取組：カマン・カレホユック（トルコ）において出土する青銅器時代の鉄分を多く含む石材、スラグ、金属製遺物の地球化学的解析
kn-title=Early Efforts for Iron Production in Central Anatolia: Geochemical Analysis of Iron-rich Stones, Slags and Metal Objects from the Bronze Age in Kaman-Kalehöyük (Turkey)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KUCUKARSLAN NURCAN
en-aut-sei=KUCUKARSLAN NURCAN
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama university
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
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dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=局在した光により誘起される化学反応とその金属ナノ加工への応用
kn-title=Chemical reactions induced by localized light and their application to metal nanofabrication
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TAKEUCHIYuki
en-aut-sei=TAKEUCHI
en-aut-mei=Yuki
kn-aut-name=竹内祐貴
kn-aut-sei=竹内
kn-aut-mei=祐貴
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama university
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
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start-page=
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dt-accepted=
dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=乳がんコホートより免疫関連遺伝子シグネチャーの化学療法の効果と予後予測能の検討
kn-title=Predictive value of immune genomic signatures from breast cancer cohorts containing data for both response to neoadjuvant chemotherapy and prognosis after surgery
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ZHUYIDAN
en-aut-sei=ZHU
en-aut-mei=YIDAN
kn-aut-name=朱一丹
kn-aut-sei=朱
kn-aut-mei=一丹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=134
cd-vols=
no-issue=3
article-no=
start-page=139
end-page=141
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2021 Incentive Award of the Okayama Medical Association in Neuroscience (2021 Niimi Prize)
kn-title=令和３年度岡山医学会賞　脳神経研究奨励賞（新見賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NojimaKojiro
en-aut-sei=Nojima
en-aut-mei=Kojiro
kn-aut-name=野島弘二郎
kn-aut-sei=野島
kn-aut-mei=弘二郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　分子医化学
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=2
article-no=
start-page=41
end-page=49
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=2022
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Interpretation of the official Japanese translation summary of the “MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy” (Updated 2019-2020)
kn-title=「MASCC/ISOO 口腔粘膜障害のマネジメントに関する臨床ガイドライン（2019-2020改訂版）」公式日本語訳概要の解釈について
en-subtitle=
kn-subtitle=
en-abstract=Adverse events frequently occur with chemotherapy, radiation therapy involving the oral cavity, and hematopoietic stem cell transplantation in cancer treatment. The Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology (MASCC/ISOO) have developed a systematic review methodology and published a updated version of the “MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy” in 2019-2020. In addition, an official Japanese translation of the summary overview was also published. However, because it is an international guideline, some references are made to unapproved drugs or off-label use in Japan. In addition, some parts of the summary outline do not convey the intent derived from the original text. This paper introduces the contents of the revised guideline and details the contents of the summary overview of the guideline with the above-mentioned problems in mind.
kn-abstract=がん治療における化学療法、口腔を照射野に含む放射線療法、および造血幹細胞移植では、有害事象として口腔粘膜障害がしばしば発生する。がん支持療法の国際学会であるMultinational Association of Supportive Care in Cancer および International Society for Oral Oncology (MASCC/ISOO)は、システマティックレビューの手法により、2019年から2020年にかけて、「MASCC/ISOO 口腔粘膜障害のマネジメントに関する臨床ガイドライン」の改訂版を発表した。さらに、総括の概要について、日本語の公式翻訳版も発表された。しかし、国際的なガイドラインであるが故に、日本での非承認薬あるいは適応外使用について言及されている内容が多い。また、総括の概要で、原文に由来する意図が伝わりにくい箇所がある。本稿では、改訂されたガイドラインの内容について紹介するとともに、上述した問題点を念頭に、ガイドラインの総括の概要に記載された内容について詳述した。
en-copyright=
kn-copyright=

en-aut-name=SOGAYoshihiko
en-aut-sei=SOGA
en-aut-mei=Yoshihiko
kn-aut-name=曽我賢彦
kn-aut-sei=曽我
kn-aut-mei=賢彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Division of Hospital Dentistry, Okayama University Hospital
kn-affil=岡山大学病院 医療支援歯科治療部
en-keyword=口腔粘膜障害
kn-keyword=口腔粘膜障害
en-keyword=口腔粘膜炎
kn-keyword=口腔粘膜炎
en-keyword=がん治療
kn-keyword=がん治療
en-keyword=ガイドライン
kn-keyword=ガイドライン
en-keyword=MASCC/ISOO
kn-keyword=MASCC/ISOO
END

start-ver=1.4
cd-journal=joma
no-vol=54
cd-vols=
no-issue=3
article-no=
start-page=61
end-page=79
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230320
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Report on the Questionary Survey Research in the Personnel Rating Systems of Enterprise
kn-title=企業の人事考課制度に関するアンケート調査の報告
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HatadaNoriko
en-aut-sei=Hatada
en-aut-mei=Noriko
kn-aut-name=畑田典子
kn-aut-sei=畑田
kn-aut-mei=典子
aut-affil-num=1
ORCID=

en-aut-name=MatsudaYoichi
en-aut-sei=Matsuda
en-aut-mei=Yoichi
kn-aut-name=松田陽一
kn-aut-sei=松田
kn-aut-mei=陽一
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科

affil-num=2
en-affil=
kn-affil=岡山大学学術研究院社会文化学域
END

start-ver=1.4
cd-journal=joma
no-vol=112
cd-vols=
no-issue=
article-no=
start-page=13
end-page=18
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on l-Glutamate Oxidase with Strict Substrate Specificity from Streptomyces sp.
kn-title=Streptomyces属放線菌由来の高基質特異性l-グルタミン酸オキシダーゼに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=l-glutamate oxidase (LGOX) from Streptomyces sp. is a heterohexameric flavin enzyme that catalyzes the oxidative deamination of l-glutamate to form α-ketoglutarate with ammonia and hydrogen peroxide. LGOX shows strict substrate specificity for l-Glu. In addition, it is highly thermostable and pH stable. Because of these properties, LGOX is currently used as a biosensor for the trace determination of l-Glu in the food industry and clinical laboratories. The full-length cDNA is 2103 bp and is encoded by a single polypeptide chain consisting of 701 residues including subunits α-γ-β. The LGOX gene was heterologously expressed in Escherichia coli JM109. The LGOX precursor expressed in E. coli is a homodimer with weak enzymatic activity and becomes a heterohexamer upon activation by protease treatment. X-ray crystallography and docking studies of purified recombinant LGOX suggest that the Arg305 residue is a key residue for substrate recognition. Mutant analysis showed that Arg305 is essential for substrate recognition, as the activity toward l-Glu was greatly reduced and substrate specificity was changed in some enzymes. The functional analysis of R305E-LGOX, which is an l-Arg oxidase, revealed that R305E-LGOX can be used as a enzyme biosensor for l-Arg.
en-copyright=
kn-copyright=

en-aut-name=NakayamaNatsume
en-aut-sei=Nakayama
en-aut-mei=Natsume
kn-aut-name=中山夏女
kn-aut-sei=中山
kn-aut-mei=夏女
aut-affil-num=1
ORCID=

en-aut-name=InagakiK.
en-aut-sei=Inagaki
en-aut-mei=K.
kn-aut-name=稲垣賢二
kn-aut-sei=稲垣
kn-aut-mei=賢二
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Course of Agrochemical Bioscience
kn-affil=農芸化学コース

affil-num=2
en-affil=
kn-affil=岡山大学学術研究院環境生命科学学域
en-keyword=l-glutamate oxidase
kn-keyword=l-glutamate oxidase
en-keyword=biosensor
kn-keyword=biosensor
en-keyword=substrate recognition
kn-keyword=substrate recognition
en-keyword=X-ray crystallography
kn-keyword=X-ray crystallography
en-keyword=modification of substrate specificity
kn-keyword=modification of substrate specificity
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220922
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=中皮腫の病原：アスベスト小体の形態学的および化学的分析
kn-title=The aetiology of mesothelioma: morphological and chemical analyses of asbestos ferruginous bodies
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AVRAMESCU MAYA LILIANA
en-aut-sei=AVRAMESCU MAYA LILIANA
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama university
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220922
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=現生サンゴ骨格中の地球化学的トレーサーに基づくインドネシア多島海表層環境の時空間的変動の復元
kn-title=Reconstructions of temporal and spatial variations in surface conditions of the Indonesian Seas based on geochemical tracers in modern coral skeletons
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=GENDAAi
en-aut-sei=GENDA
en-aut-mei=Ai
kn-aut-name=源田亜衣
kn-aut-sei=源田
kn-aut-mei=亜衣
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama university
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=
article-no=
start-page=992198
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220909
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Recruitment of Irgb6 to the membrane is a direct trigger for membrane deformation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Irgb6 is a member of interferon gamma-induced immunity related GTPase (IRG), and one of twenty "effector" IRGs, which coordinately attack parasitophorous vacuole membrane (PVM), causing death of intracellular pathogen. Although Irgb6 plays a pivotal role as a pioneer in the process of PVM disruption, the direct effect of Irgb6 on membrane remained to be elucidated. Here, we utilized artificial lipid membranes to reconstitute Irgb6-membrane interaction in vitro, and revealed that Irgb6 directly deformed the membranes. Liposomes incubated with recombinant Irgb6 were drastically deformed generating massive tubular protrusions in the absence of guanine nucleotide, or with GMP-PNP. Liposome deformation was abolished by incubating with Irgb6-K275A/R371A, point mutations at membrane targeting residues. The membrane tubules generated by Irgb6 were mostly disappeared by the addition of GTP or GDP, which are caused by detachment of Irgb6 from membrane. Binding of Irgb6 to the membrane, which was reconstituted in vitro using lipid monolayer, was stimulated at GTP-bound state. Irgb6 GTPase activity was stimulated by the presence of liposomes more than eightfold. Irgb6 GTPase activity in the absence of membrane was also slightly stimulated, by lowering ionic strength, or by increasing protein concentration, indicating synergistic stimulation of the GTPase activity. These results suggest that membrane targeting of Irgb6 and resulting membrane deformation does not require GTP, but converting into GTP-bound state is crucial for detaching Irgb6 from the membrane, which might coincident with local membrane disruption.
en-copyright=
kn-copyright=

en-aut-name=YamadaHiroshi
en-aut-sei=Yamada
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AbeTadashi
en-aut-sei=Abe
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NagaokaHikaru
en-aut-sei=Nagaoka
en-aut-mei=Hikaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakashimaEizo
en-aut-sei=Takashima
en-aut-mei=Eizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NittaRyo
en-aut-sei=Nitta
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamamotoMasahiro
en-aut-sei=Yamamoto
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakeiKohji
en-aut-sei=Takei
en-aut-mei=Kohji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Malaria Research, Proteo-Science Center, Ehime University
kn-affil=

affil-num=4
en-affil=Division of Malaria Research, Proteo-Science Center, Ehime University
kn-affil=

affil-num=5
en-affil=Division of Structural Medicine and Anatomy, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University
kn-affil=

affil-num=7
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=IFN-inducible GTPase
kn-keyword=IFN-inducible GTPase
en-keyword=Irgb6
kn-keyword=Irgb6
en-keyword=GTPase
kn-keyword=GTPase
en-keyword=membrane
kn-keyword=membrane
en-keyword=T
kn-keyword=T
en-keyword=gondii
kn-keyword=gondii
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=884509
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220510
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Dynamin is an endocytic protein that functions in vesicle formation by scission of invaginated membranes. Dynamin maintains the structure of foot processes in glomerular podocytes by directly and indirectly interacting with actin filaments. However, molecular mechanisms underlying dynamin-mediated actin regulation are largely unknown. Here, biochemical and cell biological experiments were conducted to uncover how dynamin modulates interactions between membranes and actin in human podocytes. Actin-bundling, membrane tubulating, and GTPase activities of dynamin were examined in vitro using recombinant dynamin 2-wild-type (WT) or dynamin 2-K562E, which is a mutant found in Charcot-Marie-Tooth patients. Dynamin 2-WT and dynamin 2-K562E led to the formation of prominent actin bundles with constant diameters. Whereas liposomes incubated with dynamin 2-WT resulted in tubule formation, dynamin 2-K562E reduced tubulation. Actin filaments and liposomes stimulated dynamin 2-WT GTPase activity by 6- and 20-fold, respectively. Actin-filaments, but not liposomes, stimulated dynamin 2-K562E GTPase activity by 4-fold. Self-assembly-dependent GTPase activity of dynamin 2-K562E was reduced to one-third compared to that of dynamin 2-WT. Incubation of liposomes and actin with dynamin 2-WT led to the formation of thick actin bundles, which often bound to liposomes. The interaction between lipid membranes and actin bundles by dynamin 2-K562E was lower than that by dynamin 2-WT. Dynamin 2-WT partially colocalized with stress fibers and actin bundles based on double immunofluorescence of human podocytes. Dynamin 2-K562E expression resulted in decreased stress fiber density and the formation of aberrant actin clusters. Dynamin 2-K562E colocalized with alpha-actinin-4 in aberrant actin clusters. Reformation of stress fibers after cytochalasin D-induced actin depolymerization and washout was less effective in dynamin 2-K562E-expressing cells than that in dynamin 2-WT. Bis-T-23, a dynamin self-assembly enhancer, was unable to rescue the decreased focal adhesion numbers and reduced stress fiber density induced by dynamin 2-K562E expression. These results suggest that the low affinity of the K562E mutant for lipid membranes, and atypical self-assembling properties, lead to actin disorganization in HPCs. Moreover, lipid-binding and self-assembly of dynamin 2 along actin filaments are required for podocyte morphology and functions. Finally, dynamin 2-mediated interactions between actin and membranes are critical for actin bundle formation in HPCs.
en-copyright=
kn-copyright=

en-aut-name=HamasakiEriko
en-aut-sei=Hamasaki
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WakitaNatsuki
en-aut-sei=Wakita
en-aut-mei=Natsuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YasuokaHiroki
en-aut-sei=Yasuoka
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NagaokaHikaru
en-aut-sei=Nagaoka
en-aut-mei=Hikaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MoritaMasayuki
en-aut-sei=Morita
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakashimaEizo
en-aut-sei=Takashima
en-aut-mei=Eizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=UchihashiTakayuki
en-aut-sei=Uchihashi
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakedaTetsuya
en-aut-sei=Takeda
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AbeTadashi
en-aut-sei=Abe
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=LeeJi-Won
en-aut-sei=Lee
en-aut-mei=Ji-Won
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=IimuraTadahiro
en-aut-sei=Iimura
en-aut-mei=Tadahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SaleemMoin A.
en-aut-sei=Saleem
en-aut-mei=Moin A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=OgoNaohisa
en-aut-sei=Ogo
en-aut-mei=Naohisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=AsaiAkira
en-aut-sei=Asai
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=NaritaAkihiro
en-aut-sei=Narita
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=TakeiKohji
en-aut-sei=Takei
en-aut-mei=Kohji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=YamadaHiroshi
en-aut-sei=Yamada
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

affil-num=1
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Division of Malaria Research, Proteo-Science Center, Ehime University
kn-affil=

affil-num=5
en-affil=Division of Malaria Research, Proteo-Science Center, Ehime University
kn-affil=

affil-num=6
en-affil=Division of Malaria Research, Proteo-Science Center, Ehime University
kn-affil=

affil-num=7
en-affil=Department of Physics, Nagoya University
kn-affil=

affil-num=8
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University
kn-affil=

affil-num=11
en-affil=Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University
kn-affil=

affil-num=12
en-affil=Bristol Renal, Translational Health Sciences, Bristol Medical School, University of Bristol
kn-affil=

affil-num=13
en-affil=Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka
kn-affil=

affil-num=14
en-affil=Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka
kn-affil=

affil-num=15
en-affil=Graduate School of Science, Nagoya University
kn-affil=

affil-num=16
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=17
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=dynamin
kn-keyword=dynamin
en-keyword=podocyte
kn-keyword=podocyte
en-keyword=actin
kn-keyword=actin
en-keyword=bundle
kn-keyword=bundle
en-keyword=GTPase
kn-keyword=GTPase
en-keyword=CMT
kn-keyword=CMT
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=集光性クロロフィルa/b複合体の分子集合に関与するインセルターゼAlb3.1の生化学的解析
kn-title=Biochemical characterization of the insertase Alb3.1 involved in the assembly of light-harvesting chlorophyll a/b complexes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MITHUN KUMAR RATHOD
en-aut-sei=MITHUN KUMAR RATHOD
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ベトナムに産する後期新生代火山岩の地球化学的研究：東南アジアにおけるプレート内火山活動とマントル内部の化学的不均質性の要因解明
kn-title=Geochemical study of Late Cenozoic mafic volcanic rocks from Vietnam: Implications for genesis of intraplate volcanism and mantle heterogeneity in Southeast Asia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=DAO VAN NGHIEM
en-aut-sei=DAO VAN NGHIEM
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama university
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=111
cd-vols=
no-issue=
article-no=
start-page=7
end-page=14
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on antitumor enzyme l-lysine α-oxidase from Trichoderma viride
kn-title=糸状菌Trichoderma viride由来の抗腫瘍性酵素L-リシン α-オキシダーゼに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=L-Lysine α-oxidase (LysOX) from Trichoderma viride is a homodimeric flavoenzyme that catalyzes the oxidative deamination of L-Lysine to produce α-keto-ε-aminocaproate with ammonia and hydrogen per-oxide. LysOX inhibited the growth of cancer cells but showed relatively low toxicity for normal cells. The full-length cDNA consists of 2,119 bp, and encodes a long N-terminal propeptide composed of 77 resi-dues (Met1-Arg77) and the mature protein (Ala78-Ile617). The LysOX gene was heterologously expressed in Streptomyces lividans TK24 or Escherichia coli SoluBL21. The enzymatic properties of the purified recombinant LysOX, such as substrate specificity, kinetic parameters and thermal stability, are the same as those of the native LysOX. The LysOX precursor (prLysOX) expressed in E. coli shows weak enzymatic activity and is activated by proteolytic processing. The crystal structure of prLysOX revealed that the propeptide of prLysOX indirectly changes the active site structure to inhibit enzyme activity. Moreover, the crystal structures of LysOX and its L-Lysine complex revealed that the hydrogen bonding network formed by Asp212, Asp315 and Ala440 with two water molecules is responsible for the recogni-tion of the ε-amino group of L-Lysine. In addition, a narrow substrate-binding site and acidic surface at the active site entrance both contribute to strict substrate specificity. Mutational analysis demonstrated that Asp212 and Asp315 are essential for substrate recognition, and the D212A/D315A LysOX prefers aromatic amino acids. Furthermore, the structural basis of the substrate specificity change has also been revealed by the structural analysis of the D212A/D315A LysOX and its substrate complexes. 
en-copyright=
kn-copyright=

en-aut-name=SaitoMasaya
en-aut-sei=Saito
en-aut-mei=Masaya
kn-aut-name=齋藤雅哉
kn-aut-sei=齋藤
kn-aut-mei=雅哉
aut-affil-num=1
ORCID=

en-aut-name=InagakiKenji
en-aut-sei=Inagaki
en-aut-mei=Kenji
kn-aut-name=稲垣賢二
kn-aut-sei=稲垣
kn-aut-mei=賢二
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Course of Agrochemical Bioscience
kn-affil=岡山大学農学部農芸化学コース

affil-num=2
en-affil=
kn-affil=学術研究院環境生命科学学域
en-keyword=L-lysine α-oxidase
kn-keyword=L-lysine α-oxidase
en-keyword=antitumor enzyme
kn-keyword=antitumor enzyme
en-keyword=substrate recognition
kn-keyword=substrate recognition
en-keyword=X-ray crystallography
kn-keyword=X-ray crystallography
en-keyword=enzyme activity regulation
kn-keyword=enzyme activity regulation
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210924
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=乳腺脂肪組織の微小環境下で成長する乳がん幹細胞の病理組織学的および免疫組織化学的研究)
kn-title=Histopathological and Immunohistochemical Studies on The Breast Cancer Stem Cells Developed in The Microenvironment of Mouse Mammary Fat Pads
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HAGAR ALI ABDUL RAHEEM ABU QUORA 
en-aut-sei=HAGAR ALI ABDUL RAHEEM ABU QUORA 
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=岡山大学大学院ヘルスシステム統合科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210924
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Nanogは食道がんにおける化学療法耐性のマーカーであり、鉄キレート剤の有用な治療標的である
kn-title=Nanog is a promising chemoresistant stemness marker and therapeutic target by iron chelators for esophageal cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NarusakaToru
en-aut-sei=Narusaka
en-aut-mei=Toru
kn-aut-name=鳴坂徹
kn-aut-sei=鳴坂
kn-aut-mei=徹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210924
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=腫瘍融解ウイルス治療はMDR1発現を抑制することにより骨肉腫における化学療法抵抗性を改善する
kn-title=Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SugiuKazuhisa
en-aut-sei=Sugiu
en-aut-mei=Kazuhisa
kn-aut-name=杉生和久
kn-aut-sei=杉生
kn-aut-mei=和久
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=141
cd-vols=
no-issue=10
article-no=
start-page=1155
end-page=1160
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=2021101
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Biophysical and Biochemical Research of Animal Rhodopsins
kn-title=光受容タンパク質・ロドプシンの生物物理化学研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Opsins (also called animal rhodopsins) are universal photoreceptive proteins that provide the molecular basis of visual and nonvisual photoreception in animals, including humans. Opsins consist of seven helical a-transmembrane domains and use retinal, a derivative of vitamin A, as a chromophore. In many opsins, light absorption triggers photoisomerization from 11-cis retinal to all-trans retinal, resulting in activation via dynamic structural changes in the protein moiety. Activated opsins stimulate cognate trimeric G proteins to induce signal transduction cascades in cells. Recently, molecular and physiological analyses of diverse opsins have progressively advanced. This review introduces the molecular basis and physiological  unctions of opsins. Based on the functions of opsins, I will discuss the potential of opsins as target molecules to treat and prevent visual and nonvisual diseases such as sleep disorder and depression.
en-copyright=
kn-copyright=

en-aut-name=KojimaKeiichi
en-aut-sei=Kojima
en-aut-mei=Keiichi
kn-aut-name=小島慧一
kn-aut-sei=小島
kn-aut-mei=慧一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学学術研究院医歯薬学域
en-keyword=rhodopsin
kn-keyword=rhodopsin
en-keyword=opsin
kn-keyword=opsin
en-keyword=retinal
kn-keyword=retinal
en-keyword=G protein coupled receptor
kn-keyword=G protein coupled receptor
en-keyword=vision
kn-keyword=vision
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=グラフェンの化学修飾による有機系電極材料の創出
kn-title=Robust functionalization of graphene for organic electrode materials
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=RIZWANKHAN
en-aut-sei=RIZWAN
en-aut-mei=KHAN
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama university
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=5-アミノレブリン酸を用いた光線力学療法は通常の化学療法に抵抗性の成人T細胞白血病/リンパ腫を標的とすることができる
kn-title=5-aminolevulinic acid-mediated photodynamic therapy can target aggressive adult T cell leukemia/lymphoma resistant to conventional chemotherapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SandoYasuhisa
en-aut-sei=Sando
en-aut-mei=Yasuhisa
kn-aut-name=三道康永
kn-aut-sei=三道
kn-aut-mei=康永
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=
article-no=
start-page=225
end-page=236
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210322
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Guidance Content Handled in the Compulsory Subjects ”Introduction to Industry”,”Technical Subject Teaching Methodology”and ”Topics of Vocational Guidance”for Obtaining an Industrial License Based on the Department Structure of Industrial High Schools and High School Course of Study
kn-title=工業の免許状取得の必修科目「工業概論」「工業科教育法」「職業指導概説」で取り扱う指導内容―工業系高校の学科構成と高等学校学習指導要領を踏まえて―
en-subtitle=
kn-subtitle=
en-abstract=The high school industrial department was established in response to the demands of the local industry, and has trained and produced many practical mid-career engineers. Content related to local industries is actively incorporated into education, and it is divided into specialized fields such as mechanical, electrical, chemical, architectural, civil engineering, and information systems. For this reason, faculty members in industrial departments are required to have  human resources in various specialized fields. In this paper, while clarifying the knowledge and skills required of teachers in the industrial department. Describe the guidance content that should be surely held in "Introduction to Industry", "Technical Subject Teaching Methodology (Basic I,Basic II,Applied I,Applied II)" and "Topics of Vocational Guidance ". 
kn-abstract=高等学校の工業系学科は地域の産業界の要請に応えて設置され，これまで多くの実践的な中堅技術者を育成し輩出してきた。教育には地域産業に関連した内容が積極的に取り入れられており，機械系・電気系・化学系・建築系・土木系・情報系等の専門分野に分かれている。このようなことから，工業系学科の教員には多様な専門分野の人材が必要とされる。本著では，工業系学科の教員に求められる知識・技術を明確にするとともに，「工業概論」「工業科教育法（基礎Ⅰ，基礎Ⅱ，応用Ⅰ，応用Ⅱ）」「職業指導概説」で確実に押さえておくべき指導内容について述べる。 
en-copyright=
kn-copyright=

en-aut-name=KOBAYASHISeitaro
en-aut-sei=KOBAYASHI
en-aut-mei=Seitaro
kn-aut-name=小林清太郎
kn-aut-sei=小林
kn-aut-mei=清太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Center for Teacher Education and Development, Okayama University
kn-affil=岡山大学教師教育開発センター
en-keyword=工業概論 (Introduction to Industry)
kn-keyword=工業概論 (Introduction to Industry)
en-keyword=工業科教育法（基礎Ⅰ，基礎Ⅱ，応用Ⅰ，応用Ⅱ）(Technical Subject Teaching Methodology (Basic I, Basic II, Applied I, Applied II))
kn-keyword=工業科教育法（基礎Ⅰ，基礎Ⅱ，応用Ⅰ，応用Ⅱ）(Technical Subject Teaching Methodology (Basic I, Basic II, Applied I, Applied II))
en-keyword=職業指導概説 (Topics of Vocational Guidance)
kn-keyword=職業指導概説 (Topics of Vocational Guidance)
en-keyword=基幹学科別にみた主な学科別学級数 (Number of Classes by Major Departments by Core Department)
kn-keyword=基幹学科別にみた主な学科別学級数 (Number of Classes by Major Departments by Core Department)
en-keyword=高等学校学習指導要領 (High School Course of Study)
kn-keyword=高等学校学習指導要領 (High School Course of Study)
END

start-ver=1.4
cd-journal=joma
no-vol=45
cd-vols=
no-issue=2
article-no=
start-page=121
end-page=130
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=2020
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The activity of AMPA-type glutamate receptor is involved in insulin release from pancreatic β-cells. However, the mechanism and dynamics that underlie AMPA receptor-mediated insulin release in β-cells is largely unknown. Here, we show that AMPA induces internalization of glutamate receptor 2/3 (GluR2/3), AMPA receptor subtype, in the mouse β-cell line MIN6. Immunofluorescence experiments showed that GluR2/3 appeared as fine dots that were distributed throughout MIN6 cells. Intracellular GluR2/3 co-localized with AP2 and clathrin, markers for clathrin-coated pits and vesicles. Immunoelectron microscopy revealed that GluR2/3 was also localized at plasma membrane. Surface biotinylation and immunofluorescence measurements showed that addition of AMPA caused an approximate 1.8-fold increase in GluR2/3 internalization under low-glucose conditions. Furthermore, internalized GluR2 largely co-localized with EEA1, an early endosome marker. In addition, GluR2/3 co-immunoprecipitated with cortactin, a F-actin binding protein. Depletion of cortactin by RNAi in MIN6 cells altered the intracellular distribution of GluR2/3, suggesting that cortactin is involved in internalization of GluR2/3 in MIN6 cells. Taken together, our results suggest that pancreatic β-cells adjust the amount of AMPA-type GluR2/3 on the cell surface to regulate the receptive capability of the cell for glutamate.
en-copyright=
kn-copyright=

en-aut-name=LaThe Mon
en-aut-sei=La
en-aut-mei=The Mon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamadaHiroshi
en-aut-sei=Yamada
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SeirikiSayaka
en-aut-sei=Seiriki
en-aut-mei=Sayaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=LiShun-AI
en-aut-sei=Li
en-aut-mei=Shun-AI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiseKenshiro
en-aut-sei=Fujise
en-aut-mei=Kenshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KatsumiNatsuho
en-aut-sei=Katsumi
en-aut-mei=Natsuho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=AbeTadashi
en-aut-sei=Abe
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=WatanabeMasami
en-aut-sei=Watanabe
en-aut-mei=Masami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TakeiKohji
en-aut-sei=Takei
en-aut-mei=Kohji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 
kn-affil=

affil-num=6
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 
kn-affil=

affil-num=7
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=endocytosis
kn-keyword=endocytosis
en-keyword=GluR2
kn-keyword=GluR2
en-keyword=AMPA
kn-keyword=AMPA
en-keyword=cortactin
kn-keyword=cortactin
en-keyword=MIN6
kn-keyword=MIN6
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=電気化学的手法によるグラフェンの作製と機能化および蓄電デバイスへの適用
kn-title=Electrochemical synthesis and functionalization of graphene materials for energy storage devices
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=CampéonBenoît Denis Louis
en-aut-sei=Campéon
en-aut-mei=Benoît Denis Louis
kn-aut-name=CAMPEONBENOIT DENIS LOUIS
kn-aut-sei=CAMPEON
kn-aut-mei=BENOIT DENIS LOUIS
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=フィラメンタス窒素固定シアノバクテリアであるアナベナsp. PCC 7120由来光化学系 I 四量体の精製と特性・構造解析
kn-title=Isolation, characterization and structural analysis of tetrameric photosystem I from a filamentous N2 fixing cyanobacterium Anabaena sp. PCC 7120
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=JiangTianyi
en-aut-sei=Jiang
en-aut-mei=Tianyi
kn-aut-name=蒋天翼
kn-aut-sei=蒋
kn-aut-mei=天翼
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=34
cd-vols=
no-issue=12
article-no=
start-page=16449
end-page=16463
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201017
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Dynamin 1 is a neuronal endocytic protein that participates in vesicle formation by scission of invaginated membranes. Dynamin 1 is also expressed in the kidney; however, its physiological significance to this organ remains unknown. Here, we show that dynamin 1 is crucial for microtubule organization and stabilization in glomerular podocytes. By immunofluorescence and immunoelectron microscopy, dynamin 1 was concentrated at microtubules at primary processes in rat podocytes. By immunofluorescence of differentiated mouse podocytes (MPCs), dynamin 1 was often colocalized with microtubule bundles, which radially arranged toward periphery of expanded podocyte. In dynamin 1-depleted MPCs by RNAi, alpha-tubulin showed a dispersed linear filament-like localization, and microtubule bundles were rarely observed. Furthermore, dynamin 1 depletion resulted in the formation of discontinuous, short acetylated alpha-tubulin fragments, and the decrease of microtubule-rich protrusions. Dynamins 1 and 2 double-knockout podocytes showed dispersed acetylated alpha-tubulin and rare protrusions. In vitro, dynamin 1 polymerized around microtubules and cross-linked them into bundles, and increased their resistance to the disassembly-inducing reagents Ca(2+)and podophyllotoxin. In addition, overexpression and depletion of dynamin 1 in MPCs increased and decreased the nocodazole resistance of microtubules, respectively. These results suggest that dynamin 1 supports the microtubule bundle formation and participates in the stabilization of microtubules.
en-copyright=
kn-copyright=

en-aut-name=LaThe Mon
en-aut-sei=La
en-aut-mei=The Mon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TachibanaHiromi
en-aut-sei=Tachibana
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=LiShun-Ai
en-aut-sei=Li
en-aut-mei=Shun-Ai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AbeTadashi
en-aut-sei=Abe
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SeirikiSayaka
en-aut-sei=Seiriki
en-aut-mei=Sayaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NagaokaHikaru
en-aut-sei=Nagaoka
en-aut-mei=Hikaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakashimaEizo
en-aut-sei=Takashima
en-aut-mei=Eizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakedaTetsuya
en-aut-sei=Takeda
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OgawaDaisuke
en-aut-sei=Ogawa
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MakinoShin-Ichi
en-aut-sei=Makino
en-aut-mei=Shin-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AsanumaKatsuhiko
en-aut-sei=Asanuma
en-aut-mei=Katsuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=WatanabeMasami
en-aut-sei=Watanabe
en-aut-mei=Masami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TianXuefei
en-aut-sei=Tian
en-aut-mei=Xuefei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=IshibeShuta
en-aut-sei=Ishibe
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=SakaneAyuko
en-aut-sei=Sakane
en-aut-mei=Ayuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=SasakiTakuya
en-aut-sei=Sasaki
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=TakeiKohji
en-aut-sei=Takei
en-aut-mei=Kohji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=YamadaHiroshi
en-aut-sei=Yamada
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

affil-num=1
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Division of Malaria Research, Proteo-Science Center, Ehime University
kn-affil=

affil-num=7
en-affil=Division of Malaria Research, Proteo-Science Center, Ehime University
kn-affil=

affil-num=8
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Nephrology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=11
en-affil=Department of Nephrology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=12
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Department of Internal Medicine, Section of Nephrology, Yale University School of Medicine
kn-affil=

affil-num=14
en-affil=Department of Internal Medicine, Section of Nephrology, Yale University School of Medicine
kn-affil=

affil-num=15
en-affil=Department of Biochemistry, Tokushima University Graduate School of Medical Sciences
kn-affil=

affil-num=16
en-affil=Department of Biochemistry, Tokushima University Graduate School of Medical Sciences
kn-affil=

affil-num=17
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=18
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=19
en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=dynamin
kn-keyword=dynamin
en-keyword=microtubules
kn-keyword=microtubules
en-keyword=podocyte
kn-keyword=podocyte
en-keyword=primary process
kn-keyword=primary process
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=化学療法誘発性末梢神経障害が婦人科がんサバイバーにおける生活の質に及ぼす影響
kn-title=The Influence of Chemotherapy-Induced Peripheral Neuropathy on Quality of Life of Gynecologic Cancer Survivors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsuokaHirofumi
en-aut-sei=Matsuoka
en-aut-mei=Hirofumi
kn-aut-name=松岡敬典
kn-aut-sei=松岡
kn-aut-mei=敬典
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=10
article-no=
start-page=103
end-page=115
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=19820301
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=『連環記』論――「連環」の形態と世界への展開――
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=林正子
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affil-num=1
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en-title=Drug interaction（46. Blending change and interaction of an injection drug）
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affil-num=3
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en-title=The 2018 Incentive Award of the Okayama Medical Association in Neuroscience (2018 Niimi Prize)
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en-aut-name=EdamatsuMidori
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affil-num=1
en-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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en-title=高IgG4血症患者の臨床的および生化学的特徴
kn-title=Clinical and biochemical characteristics of patients having general symptoms with increased serum IgG4 
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en-aut-name=HasegawaKo
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affil-num=1
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kn-title=1,10-Phenanthroline- or Electron-Promoted Cyanation of Aryl Iodides
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A 1,10-phenanthroline-promoted cyanation of aryl iodides has been developed. 1,10-Phenanthroline worked as an organocatalyst for the reaction of aryl iodides with tetraalkylammonium cyanide to afford aryl cyanides. A similar reaction occurred through an electroreductive process.
en-copyright=
kn-copyright=

en-aut-name=MitsudoKoichi
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en-aut-name=YoshiokaKazuki
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en-aut-name=HirataTakayuki
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en-aut-name=MandaiHiroki
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en-aut-name=MidorikawaKoji
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en-aut-name=SugaSeiji
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aut-affil-num=6
ORCID=

affil-num=1
en-affil= Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil= Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil= Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil= Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil= Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil= Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=cyanation
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en-keyword=organocatalysis
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en-keyword=electrochemistry
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en-keyword=aryl iodides
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END

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cd-journal=joma
no-vol=21
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start-page=2171
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dt-accepted=
dt-pub-year=2019
dt-pub=20190307
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en-title=
kn-title=Iodide-Mediated or Iodide-Catalyzed Demethylation and Friedel-Crafts C-H Borylative Cyclization Leading to Thiophene-Fused 1,2-Oxaborine Derivatives
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The first synthesis of dithieno-1,2-oxaborine derivatives was achieved via iodide-mediated or iodide-catalyzed demethylation of 3-methoxy-2,2'-bithiophene and subsequent C-H borylation. A wide variety of thiophene-fused oxaborines could be synthesized by the procedure.
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affil-num=1
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kn-affil=

affil-num=2
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Institute for Chemical Research, Kyoto University
kn-affil=

affil-num=6
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=7
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
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END

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kn-title=ラットを用いた化学物質曝露による生体内ホルモンレベルの変動要因解析
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en-aut-name=YamaguchiTakafumi
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aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
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kn-subject=
en-title=光化学的内在化（PCI）の機構解明，およびマウス初期胚へのRNAデリバリーへの応用
kn-title=The influence of physicochemical parameters on photochemical internalization (PCI) mechanism and application of PCI as a photo-dependent RNA delivery strategy to mouse embryo
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en-aut-name=TET HTUT SOE
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aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
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en-title=腫瘍関連マクロファージにより誘導された上皮間葉移行は膵臓癌腹膜において化学療法抵抗性を引き起こす
kn-title=The epithelial-to-mesenchymal transition induced by tumor-associated macrophages confers chemoresistance in peritoneally disseminated pancreatic cancer
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kn-subtitle=
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en-aut-name=KuwadaKazuya
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kn-aut-mei=和也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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cd-journal=joma
no-vol=131
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start-page=13
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dt-pub-year=2019
dt-pub=20190401
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kn-subject=
en-title=The 2017 Incentive Award of the Okayama Medical Association in General Medical Science (2017 Yuuki Prize)
kn-title=平成29年度岡山医学会賞 総合研究奨励賞（結城賞）
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kn-subtitle=
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en-aut-name=TakedaTetsuya
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kn-aut-mei=哲也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　生化学
END

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cd-journal=joma
no-vol=35
cd-vols=
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article-no=
start-page=22
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dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
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en-subject=
kn-subject=
en-title=Biochemical Evaluation of Maternal Stress by Separating Infant Mice for Animal Experiments
kn-title=新生児マウスを用いる動物実験が母マウスにもたらすストレスの生化学的評価
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Corticosterone, the glucocorticoid in rodents, is released from adrenal cortex in response to stress. Sometimes, for use in experiments, infants may be separated from their mother mouse. We studied the stress of mother mouse when she separates from infants. As a result, the concentration of corticosterone in the blood of the mother mouse tended to increase, by pulling her infants apart. In the case of using infant mice for animal experiments, it was suggested that it is necessary to consider the maternal stress.
en-copyright=
kn-copyright=

en-aut-name=YataNorio
en-aut-sei=Yata
en-aut-mei=Norio
kn-aut-name=矢田範夫
kn-aut-sei=矢田
kn-aut-mei=範夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Advanced Science Research Center, Okayama University
kn-affil=岡山大学 自然生命科学研究支援センター
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=酸素発生光化学系IIの構造・機能解析
kn-title=Structural and functional studies of oxygen-evolving photosystem II
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakajimaYoshiki
en-aut-sei=Nakajima
en-aut-mei=Yoshiki
kn-aut-name=中島芳樹
kn-aut-sei=中島
kn-aut-mei=芳樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=総合内科診療における、主訴と年齢に着目した血液生化学マーカーの変化について
kn-title=Changes in Serum Biochemical Markers in Relation to Chief Complaints and Aging in General Medicine
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OmuraDaisuke
en-aut-sei=Omura
en-aut-mei=Daisuke
kn-aut-name=大村大輔
kn-aut-sei=大村
kn-aut-mei=大輔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=化学放射線併用治療中に測定されたGPS(Glasgow prognostic score)は子宮頚癌において重要な予後因子となる
kn-title=The Glasgow Prognostic Score Determined During Concurrent Chemoradiotherapy Is an Independent Predictor of Survival for Cervical Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NishidaTakeshi
en-aut-sei=Nishida
en-aut-mei=Takeshi
kn-aut-name=西田傑
kn-aut-sei=西田
kn-aut-mei=傑
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ago2タンパク質に関連した循環マイクロRNA測定を用いた大腸癌化学療法患者の抗腫瘍効果のモニタリング
kn-title=Detection of Circulating MicroRNAs with Ago2 Complexes to Monitor the Tumor Dynamics of Colorectal Cancer Patients during Chemotherapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujiTomokazu
en-aut-sei=Fuji
en-aut-mei=Tomokazu
kn-aut-name=藤智和
kn-aut-sei=藤
kn-aut-mei=智和
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=130
cd-vols=
no-issue=3
article-no=
start-page=129
end-page=133
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20181203
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Two Nobel laureates, Alexis Carrel and Peyton Rous, intended to use cells in culture for theirresearch at the beginning of the 20th century
kn-title=20世紀初頭に培養細胞に関心を示した 2人のノーベル賞受賞者 : Alexis Carrelと Peyton Rous
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=21世紀になって2017年までに，34件のノーベル生理学・医学賞と化学賞が出ているが，その約半数の研究に培養細胞（動物の細胞，あるいは，イースト）が使われている．すなわち，現代の生命科学の研究には，培養細胞がきわめて大きな役割を果たしているといえる．今回は，今から約100年前，細胞を培養して研究を進めようとした先見性に富んだ 2人のノーベル生理学・医学賞受賞者，Alexis Carrel（以下，本文ではカレルとする）と Peyton Rous（以下，ラウス）の経歴と業績を紹介し，彼等の培養細胞との係りについて述べる．
en-copyright=
kn-copyright=

en-aut-name=NambaMasayoshi
en-aut-sei=Namba
en-aut-mei=Masayoshi
kn-aut-name=難波正義
kn-aut-sei=難波
kn-aut-mei=正義
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Okayama Medical Foundation
kn-affil=岡山医学振興会
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=3-4
article-no=
start-page=634
end-page=599
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190319
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=事実婚・内縁の死亡解消における居住権と夫婦財産制 : 2018年相続法改正による生存配偶者の居住権の新設を契機に
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FurukawaY.
en-aut-sei=Furukawa
en-aut-mei=Y.
kn-aut-name=古川瓔子
kn-aut-sei=古川
kn-aut-mei=瓔子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=福山大学人間文化学科
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=13
end-page=22
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190320
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Departure From "I Do Not Want to Learn These Matters Over and Over" 3 Years Challenge in Okayama Prefecture Board of Education
kn-title=「またやるのですか？」からの出発 : 岡山県教委の不祥事対策の3年
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　岡山県教育委員会が取り組んできた不祥事対策について，その特徴を回顧的に述べた上で，3年が経過した現在の成果について紹介した。ともすると不祥事対策は「言われるからやりました」というアリバイ作り的なものになりやすく，研修の場での発言も形式的なものに傾きやすい。そうした動機づけの低さを「多忙な教員として自然な反応」と認識したうえで，生徒理解を超え，教師自身の人生理解に役に立つように研修資料を作りこんできた結果，現場では「研修を受けてよかった」「研修を繰り返すことに意味があると思える」という声も聞かれるようになった
en-copyright=
kn-copyright=

en-aut-name=TsukamotoChiaki
en-aut-sei=Tsukamoto
en-aut-mei=Chiaki
kn-aut-name=塚本千秋
kn-aut-sei=塚本
kn-aut-mei=千秋
aut-affil-num=1
ORCID=

en-aut-name=HiraShinji
en-aut-sei=Hira
en-aut-mei=Shinji
kn-aut-name=平伸二
kn-aut-sei=平
kn-aut-mei=伸二
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科

affil-num=2
en-affil=
kn-affil=福山大学人間文化学部
en-keyword=不祥事対策
kn-keyword=不祥事対策
en-keyword=動機づけの低さ
kn-keyword=動機づけの低さ
en-keyword=研修資料
kn-keyword=研修資料
en-keyword=作成の工程
kn-keyword=作成の工程
en-keyword=現場の声
kn-keyword=現場の声
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20181227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=線量体積因子は非小細胞肺癌に対する導入同時併用化学放射線療法おける術後の放射線肺臓炎を予測する
kn-title=Dose-Volume Parameters Predict Radiation Pneumonitis after Surgery with Induction Concurrent Chemoradiotherapy for Non-small Cell Lung Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OgataTakeshi
en-aut-sei=Ogata
en-aut-mei=Takeshi
kn-aut-name=尾形毅
kn-aut-sei=尾形
kn-aut-mei=毅
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=108
cd-vols=
no-issue=
article-no=
start-page=5
end-page=13
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of boron deficiency on tip burn and malformed fruit incidence in strawberries
kn-title=B（ホウ素）欠乏処理がイチゴのチップバーンおよび受精不良果発生に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=　B（ホウ素）は植物にとって必須な微量要素であり，イチゴの受精不良果発生要因の1 つである．そこで2015年度と2016年度の2 回にわたりB 欠乏がイチゴの受精不良果発生に及ぼす影響について調査した．また，2016年度はB 欠乏処理後にB 回復処理を行い，その後のイチゴの果実形態の変化についても調査した．その結果，B欠乏処理を行うと蒸散機能の低い新葉や花芽においてチップバーンが発生し，種浮き果や部分不受精を主とした受精不良果が多発した．しかし，B 回復処理を行うことでこれらの症状が改善することが明らかになった．B は受精不良果発生に関係しており，欠乏条件下で根から吸収させると急速に若い成長中の組織に転流することが示されたことから，B 栄養をコントロールすることでB 不足によるイチゴの受精不良果発生を軽減できる可能性があると考えられる．
kn-abstract=Boron (B) is an essential micro element for plants and plays important roles in the synthesis and functions of cell wall. B deficiency has been reported as one of the causes of fruit malformation in strawberries. We investigated the effect of B deficiency on flower and fruit development of forced strawberries for two cropping seasons (2015-2017). In the second season, B was resupplied for B-deficient plants and we investigated changes in fruit development. When B-free nutrient solutions were supplied, tip burn began to occur in newly emerging leaves and calyx 2 to 3 months later, and fruit malformation including seedy or only partly developed fruits with undeveloped achenes occurred frequently. However, these deficient symptoms were quickly disappeared by supplying B containing nutrient solutions. In conclusion, B nutrition is closely related to the occurrence of fruit malformation through fertility of pollen and pistils, and also development of receptacle tissue in strawberries. It should be possible to reduce fruit malformation in strawberries by proper control of B nutrition.
en-copyright=
kn-copyright=

en-aut-name=SesumiMiho
en-aut-sei=Sesumi
en-aut-mei=Miho
kn-aut-name=瀬角美穂
kn-aut-sei=瀬角
kn-aut-mei=美穂
aut-affil-num=1
ORCID=

en-aut-name=YoshidaYuichi
en-aut-sei=Yoshida
en-aut-mei=Yuichi
kn-aut-name=吉田裕一
kn-aut-sei=吉田
kn-aut-mei=裕一
aut-affil-num=2
ORCID=

en-aut-name=KinjoAkari
en-aut-sei=Kinjo
en-aut-mei=Akari
kn-aut-name=金城朱理
kn-aut-sei=金城
kn-aut-mei=朱理
aut-affil-num=3
ORCID=

en-aut-name=HidakaKei
en-aut-sei=Hidaka
en-aut-mei=Kei
kn-aut-name=日高啓
kn-aut-sei=日高
kn-aut-mei=啓
aut-affil-num=4
ORCID=

en-aut-name=GotoTanjuro
en-aut-sei=Goto
en-aut-mei=Tanjuro
kn-aut-name=後藤丹十郎
kn-aut-sei=後藤
kn-aut-mei=丹十郎
aut-affil-num=5
ORCID=

en-aut-name=YasubaKen-ichiro
en-aut-sei=Yasuba
en-aut-mei=Ken-ichiro
kn-aut-name=安場健一郎
kn-aut-sei=安場
kn-aut-mei=健一郎
aut-affil-num=6
ORCID=

en-aut-name=TanakaYoshiyuki
en-aut-sei=Tanaka
en-aut-mei=Yoshiyuki
kn-aut-name=田中義行
kn-aut-sei=田中
kn-aut-mei=義行
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Graduate school of Environmental and Life Science
kn-affil=岡山大学大学院　環境生命科学研究科

affil-num=2
en-affil=Graduate school of Environmental and Life Science
kn-affil=岡山大学大学院　環境生命科学研究科

affil-num=3
en-affil=Graduate school of Environmental and Life Science
kn-affil=岡山大学大学院　環境生命科学研究科

affil-num=4
en-affil=Asahi Kagaku Kogyo Co., Ltd.)
kn-affil=旭化学工業

affil-num=5
en-affil=Graduate school of Environmental and Life Science
kn-affil=岡山大学大学院　環境生命科学研究科

affil-num=6
en-affil=Graduate school of Environmental and Life Science
kn-affil=岡山大学大学院　環境生命科学研究科

affil-num=7
en-affil=Graduate school of Environmental and Life Science
kn-affil=岡山大学大学院　環境生命科学研究科
en-keyword=floral organs
kn-keyword=floral organs
en-keyword=Fragaria × ananassa Duch.
kn-keyword=Fragaria × ananassa Duch.
en-keyword=pistil fertility
kn-keyword=pistil fertility
en-keyword=receptacle growth
kn-keyword=receptacle growth
en-keyword=seedy fruit
kn-keyword=seedy fruit
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180927
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=化学合成依存動物の無機窒素栄養源に関する地球化学的研究
kn-title=Geochemical studies of inorganic nitrogen source for chemosynthesis-based animals
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnishiYuji
en-aut-sei=Onishi
en-aut-mei=Yuji
kn-aut-name=大西雄二
kn-aut-sei=大西
kn-aut-mei=雄二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=37
cd-vols=
no-issue=
article-no=
start-page=21
end-page=35
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=2018
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Der Entwurf Friedrich Schinkels zur Aufstellung der Gemälde im Alten Museum Berlin
kn-title=フリードリヒ・シンケルの建築と美術史 : ベルリン旧博物館における絵画の展示をめぐって
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Dieser Aufsatz behandelt die Anordnung der Gemälde im Alten Museum Berlin bei seiner Eröffnung im Jahr 1830. Damals vertraten die Teilnehmer der Kommission zur Einrichtung des Museums sehr unterschiedliche Meinungen über die mögliche Aufhängung der Exponate. Das Alte Museum Berlin war eines der ersten Museen in Deutschland und es gab damals noch keine grundsätzlichen Empfehlungen oder Vorgaben zur Anordnung von Kunstwerken.
 In diesem Zusammenhang sind bisher vor allem die Bemerkungen des Vorsitzenden der Kommission, Wilhelm von Humboldt, mit Blick auf seine Sprachphilosophie untersucht worden. Der Schwerpunkt der folgenden Betrachtung liegt auf der von dem Architekten des Museums, Karl Friedrich Schinkel, vertretenen Auffassung zur Anordnung der Ausstellungsstücke. Dabei soll nicht nur die Kunstanschauung Schinkels selbst, sondern auch die Bedeutung des Museums als moderne Institution Berlins berücksichtigt werden.
 Einer Vorlesung des Archäologen Aloys Hirt im Jahr 1797 ist zu entnehmen, dass er das Museum besonders für Künstler und Wissenschaftler einrichten wollte. Er betrachtete ein Museum als ein Institut, das dazu dienen sollte, den Geschmack von Künstlern und Fachleuten auszubilden und die Industrie Preußens zu entwickeln. Dagegen hielten Schinkel und der Kunsthistoriker Friedrich Waagen, deren Vorschläge erst 1828 geäußert wurden, es vielmehr für wichtig, dem „Publikum“ Kenntnisse über Kunstgeschichte zu vermitteln. Dem Entwurf von Schinkel und Waagen fügten Humboldt und der Kunsthistoriker Carl Friedrich von Rumohr ein Gutachten über ästhetische Aspekte hinzu. Obwohl Humboldts und Rumohrs Vorschläge für die Aufhängung der Gemälde sich von denen Schinkels und Waagens unterschieden, spielte Schinkels Architektur des Museumsgebäudes eine wichtige Rolle dabei, die Ziele beider Seiten zu verwirklichen.
 Der Aufsatz kommt zu dem Schluss, dass das Alte Museum für Schinkel nicht nur Ausdruck seiner Verehrung für die Antike war, wie oft gesagt wird, sondern auch ein Mittel darstellte, das Publikum des 19. Jahrhunderts durch kunstgeschichtliche Kenntnisse mit der Antike zu verbinden.
en-copyright=
kn-copyright=

en-aut-name=MitsuiMao
en-aut-sei=Mitsui
en-aut-mei=Mao
kn-aut-name=三井麻央
kn-aut-sei=三井
kn-aut-mei=麻央
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=130
cd-vols=
no-issue=1
article-no=
start-page=19
end-page=23
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180402
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Metaplastic carcinoma of the breast : Two cases
kn-title=症例報告 乳腺化生癌の2例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We treated two patients with a rare metaplastic carcinoma of the breast. Patient 1：A 32-year-old woman presented with a rapidly growing mass（ 7cm） in her right breast. We diagnosed cT3N0M0 Stage IIB breast cancer and performed a radical resection. The pathological diagnosis was triple-negative metaplastic carcinoma with a Ki-67 value ＞30%. Postoperative adjuvant chemotherapy and radiotherapy were performed. Patient 2：A 66-year-old postmenopausal woman presented with a left breast mass. We diagnosed cT1N0M0 Stage I breast cancer and performed a radical resection. The pathological diagnosis was triple-negative metaplastic carcinoma with a Ki-67 value ＞30%. Postoperative adjuvant chemotherapy was performed. Patients 1 and 2 have achieved relapse-free survivals of 1 year＋2 months and 10 months, respectively. Metaplastic carcinoma of the breast is a rare tumor, and its prognosis is not favorable. The only available treatment is that used for invasive ductal carcinoma；a more specific treatment has not been established. The accumulation of further similar cases and the development of a novel effective treatment are desired.
en-copyright=
kn-copyright=

en-aut-name=MotokiTakayuki
en-aut-sei=Motoki
en-aut-mei=Takayuki
kn-aut-name=元木崇之
kn-aut-sei=元木
kn-aut-mei=崇之
aut-affil-num=1
ORCID=

en-aut-name=IwamotoTakayuki
en-aut-sei=Iwamoto
en-aut-mei=Takayuki
kn-aut-name=岩本高行 
kn-aut-sei=岩本
kn-aut-mei=高行 
aut-affil-num=2
ORCID=

en-aut-name=OmoriMasako
en-aut-sei=Omori
en-aut-mei=Masako
kn-aut-name=大森昌子
kn-aut-sei=大森
kn-aut-mei=昌子
aut-affil-num=3
ORCID=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=松岡順治
kn-aut-sei=松岡
kn-aut-mei=順治
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Surgery, Okayama Saiseikai General Hospital
kn-affil=岡山済生会総合病院　外科

affil-num=2
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=岡山大学病院　新医療研究開発センター

affil-num=3
en-affil=Department of Diagnostic Pathology, Kurashiki Medical Center
kn-affil=倉敷成人病センター　病理診断科

affil-num=4
en-affil=Department of Palliative and Supportive Medicine, Okayama University Hospital
kn-affil=岡山大学病院　緩和支持医療科
en-keyword=乳癌（breast cancer）
kn-keyword=乳癌（breast cancer）
en-keyword=化生癌（metaplastic carcinoma）
kn-keyword=化生癌（metaplastic carcinoma）
en-keyword=化学療法（chemotherapy）
kn-keyword=化学療法（chemotherapy）
END

start-ver=1.4
cd-journal=joma
no-vol=130
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180402
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Adjuvant chemotherapy for non small-cell lung cancer
kn-title=非小細胞肺癌に対する術後補助化学療法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=豊岡伸一 
kn-aut-sei=豊岡
kn-aut-mei=伸一 
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　呼吸器・乳腺内分泌外科学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=エチオピア火山地域の多様な火山岩の岩石学・地球科学的特徴 : マグマ発生におけるマントルプルームの熱および化学的影響
kn-title=Petrologic and geochemical evidence for diversity of magma compositions at the Ethiopian volcanic province: implications for thermo-chemical plume influence
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=Dejene Hailemariam Feyissa
kn-aut-sei=Dejene Hailemariam Feyissa
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=中国地方の後期新生代火山岩の岩石学、年代学および地球化学的研究 : 沈み込み帯と火山弧の進化の解明
kn-title=Petrological, geochronological and geochemical study of late Cenozoic volcanic rocks from the Chugoku district, southwest Japan: Implications for the evolution of subduction zone and volcanic arc
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=Nguyen Truong Tai
kn-aut-sei=Nguyen Truong Tai
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=原発性乳癌における腫瘍浸潤リンパ球（TILs）関連遺伝子マーカーは化学療法の治療効果を予測する
kn-title=Tumour-infiltrating lymphocytes (TILs)-related genomic signature predicts chemotherapy response in breast cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KochiMariko
en-aut-sei=Kochi
en-aut-mei=Mariko
kn-aut-name=河内麻里子
kn-aut-sei=河内
kn-aut-mei=麻里子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=
article-no=
start-page=19
end-page=32
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180322
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Luo Zhenyu's Book-shopping Activities during his Visit to Japan in the Late Qing Dynasty
kn-title=清末における羅振玉の日本視察と訪書活動
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=LuShunchang
en-aut-sei=Lu
en-aut-mei=Shunchang
kn-aut-name=呂順長
kn-aut-sei=呂
kn-aut-mei=順長
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=浙江工商大学東方語言文化学院
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=
article-no=
start-page=87
end-page=106
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Japanese translation of “Lunyu Jizhu”(1) : Xi ZHU’s Interpretation of “Confucian Analects”
kn-title=『論語集注』（朱熹撰）の日本語訳（學而第一） : 『論語集注』を主とする朱子の『論語』解釈
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　周知の通り、朱憙（一一三○～一二○○。朱子は尊称）の『論語』解釈は、中国思想の発展に寄与しただけではなく、日本や朝鮮半島などの東アジアの思想の発展にも大きな影響を与えたものである。だが、『論語』には「道」「心」「徳」「君子」などの中国哲学の概念が随所に現れており、朱子哲学においてのそれらの概念の含意を明確に解明しない限り、朱子の『論語』解釈の全内容を理解することは極めて難しいと思われるのである。筆者は、長年に渡って朱子哲学の研究に力を注ぎ、いままでは既に、「朱子の「太極」と「気」（岡山大学『大学教育研究紀要』第七号、二○一一年）「朱子の「神」」（岡山大学『大学教育研究紀要』第八号、二○一二年）「朱子の「心」」（京都大学『中國思想史研究』第三十四號、二○一三年）「朱子の「理」」（岡山大学『大学教育研究紀要』第十号、二○一四年）「朱子の「情」」（岡山大学『大学教育研究紀要』第十一号、二○一五年）「朱子の「変化気質」」（『岡山大学大学院社会文化学科研究科紀要』第四三号、二○一七年）「朱子の「君子」」（『岡山大学大学院社会文化学科研究科紀要』第四四号、二○一七年）などの論文を発表した。その朱子哲学の研究を通じて、筆者は、上記の諸論文、及び『四書章句集注』（新編諸子集成、中華書局、一九八三年）と『朱子語類』（全八冊、宋・黎靖徳編、王星賢点校、一九九四年）、特に『朱子語類』に所収の「論語（一～三十二）」（巻第十九～五十）に基づいての、『論語集注』を主とする朱子の『論語』解釈の現代日本語の完全翻訳を作成することが必要だと強く思うようになったのである。本稿では、『論語集注』（前掲の『四書章句集注』に所収）の「學而第一」の朱子の集注を和訳することと、『論語』學而第一の原文を主に『朱子語類』（前掲）に所収の「論語（一～三十二）」に記録されている朱子の説明に基づいて和訳することを試 みる。
en-copyright=
kn-copyright=

en-aut-name=SunLuyi
en-aut-sei=Sun
en-aut-mei=Luyi
kn-aut-name=孫路易
kn-aut-sei=孫
kn-aut-mei=路易
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Institute for Education and Student Services, Okayama University
kn-affil=岡山大学全学教育・ 学生支援機構
en-keyword=理
kn-keyword=理
en-keyword=道
kn-keyword=道
en-keyword=徳
kn-keyword=徳
en-keyword=性
kn-keyword=性
en-keyword=敬
kn-keyword=敬
en-keyword=君子
kn-keyword=君子
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170929
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=カメルーン火山列の地球化学的研究：パッシブ・マージンプレート内マグマの成因）
kn-title=Geochemical Study of the Cameroon Volcanic Line: Implication for the Genesis of Passive Margin Intraplate Magmatism 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Iyasu Getachew Belay
en-aut-sei=Iyasu Getachew Belay
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Tchnology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170929
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト腎におけるVasohibin-2の免疫組織化学的評価：　耐糖能障害と腎機能障害への意義
kn-title=Immunohistochemistry of Vasohibin-2 in Human Kidney Disease: Implication in Impaired Glucose Tolerance and Reduced Renal Function
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ArataYuka
en-aut-sei=Arata
en-aut-mei=Yuka
kn-aut-name=荒田夕佳
kn-aut-sei=荒田
kn-aut-mei=夕佳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=BRAF V600E変異はStageⅣ結腸直腸癌に対する術前化学療法の適応予測因子である
kn-title=BRAF V600E mutation is a predictive indicator of upfront chemotherapy for stage IV colorectal cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MorikawaTatsuya
en-aut-sei=Morikawa
en-aut-mei=Tatsuya
kn-aut-name=森川達也
kn-aut-sei=森川
kn-aut-mei=達也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=マウスモデルを用いた大気中の化学物質により引き起こされる吸入アレルギーの病態解明に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TajikiRisako
en-aut-sei=Tajiki
en-aut-mei=Risako
kn-aut-name=田食里沙子
kn-aut-sei=田食
kn-aut-mei=里沙子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=低分子医薬品を指向したペプチドミメティクスの工業的化学合成法の開発研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SawaiYasuhiro
en-aut-sei=Sawai
en-aut-mei=Yasuhiro
kn-aut-name=澤井泰宏
kn-aut-sei=澤井
kn-aut-mei=泰宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=西南日本の新生代アダカイトの地球化学的および年代学的研究：若く温かい沈み込み帯におけるスラブ・マントル相互作用
kn-title=Geochemical and Geochronological Study of the Cenozoic Adakitic Lavas from SW Japan: Implications for the Slab-Mantle Interactions in a Hot Subduction System
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Pineda VelascoIvan
en-aut-sei=Pineda Velasco
en-aut-mei=Ivan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Tchnology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=抗糖尿病作用を有する亜鉛錯体の生体内挙動の可視化と生体内化学形態変化の解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MunekaneMasayuki
en-aut-sei=Munekane
en-aut-mei=Masayuki
kn-aut-name=宗兼将之
kn-aut-sei=宗兼
kn-aut-mei=将之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=口腔扁平上皮癌に対する術前化学療法のがん微小環境に及ぼす免疫学的変化
kn-title=The Immunological Impact of Chemotherapy on the Tumor Microenvironment of Oral Squamous Cell Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakakuraHiroaki
en-aut-sei=Takakura
en-aut-mei=Hiroaki
kn-aut-name=高倉裕明
kn-aut-sei=高倉
kn-aut-mei=裕明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=61
end-page=70
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170327
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Self-Reliance Activities Based on Self-Understanding for Autistic Child Have Probrems in Emotional Stability : An Analysis of Teaching Records Focused on Self-Regulation Scales
kn-title=情緒の安定に課題のある自閉症児への自己理解に基づく自立活動 : 自己制御機能に着目した指導記録の分析
en-subtitle=
kn-subtitle=
en-abstract=　In this study, we focused on teaching record of self-reliance activity whose actions an autistic child who has intellectual disabilities and present behavioral problems due to the emotional stability problem improved; We investigated the involvement of self-understanding in the course of setting and guidance. For the record analysis, we adapted the self-regulation scale, which is considered to play an important role in improving the behavioral problem, to verify the effectiveness of goal and content setting and to grasp the mode of guidance of self-understanding. The results showed that the guidance targets and guidance contents set for the child who presented behavioral problems while taking mental burdens into account, as a result, elements of the self-regulation function were set stepwise and resulted in improved behavior Furthermore, introduction of the teaching method to encourage self-understanding has revealed that the targeted child urges the child to acquire the ability to resolve the difficulty subjectively. From the results, it is clear that even if children with autistic disorders with intellectual impairment are used, using the teaching method to encourage self-understanding based on task setting according to the actual situation, it is possible that the target child will develop the ability to subject the difficulty to subjective improvement It was suggested that it is possible.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=大野呂浩志
kn-aut-sei=大野呂
kn-aut-mei=浩志
aut-affil-num=1
ORCID=

en-aut-name=NakayaAkitaka
en-aut-sei=Nakaya
en-aut-mei=Akitaka
kn-aut-name=仲矢明孝
kn-aut-sei=仲矢
kn-aut-mei=明孝
aut-affil-num=2
ORCID=

affil-num=1
en-affil=The University of Hiroshima Bunka Gakuen
kn-affil=広島文化学園大学 学芸学部 子ども学科

affil-num=2
en-affil=Graduate School of Education,Okayama University
kn-affil=岡山大学大学院教育学研究科
en-keyword=自閉症 (autism)
kn-keyword=自閉症 (autism)
en-keyword=情緒の安定 (emotional stability)
kn-keyword=情緒の安定 (emotional stability)
en-keyword=自立活動 (self-reliance activities)
kn-keyword=自立活動 (self-reliance activities)
en-keyword=自己理解 (self-perception)
kn-keyword=自己理解 (self-perception)
en-keyword=自己制御機能 (self-regulation)
kn-keyword=自己制御機能 (self-regulation)
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=11
end-page=20
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170327
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=How Can We Practice Life-Education as Moral Education in Junior High School?（2）
kn-title=中学校の道徳教育において〈いのち〉の教育を どのように実践するか（２）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　阪神・淡路大震災と東日本大震災では，大人だけでなく，多くの子どもたちが犠牲となった。改めて｢命の教育｣の重要性が指摘されている。また，青少年，特に中学生による殺傷事件やいじめによる自殺も後を絶たない現状にある。一方，2019（平成31）年度から中学校の「道徳の時間」は「特別の教科􀀃 道徳」という名称の教科となる。その理由は様々であるが，教育再生実行会議の第一次提言によれば，同会議が教科化提言に踏み切った直接の要因は，いじめ問題への実効性のある道徳教育を求めることにあった。しかし，学校の道徳教育や「命の教育」は役に立たないという指摘もあり，教科となった道徳科における道徳教育は，これまでの諸課題を確実に見直し，確たる実践的基盤を打ち立てなければならない。本稿（２）では，前号の（１）で論じた〈いのち〉とその教育に関する独自の観点によりながら，「〈いのち〉の教育」に取り組む「道徳科の授業」の新しい展開を提案したい。
en-copyright=
kn-copyright=

en-aut-name=WatanabeMichiru
en-aut-sei=Watanabe
en-aut-mei=Michiru
kn-aut-name=渡邉満
kn-aut-sei=渡邉
kn-aut-mei=満
aut-affil-num=1
ORCID=

en-aut-name=KokayashiMariko
en-aut-sei=Kokayashi
en-aut-mei=Mariko
kn-aut-name=小林万里子
kn-aut-sei=小林
kn-aut-mei=万里子
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Hiroshima Bunka Gakuen University
kn-affil=広島文化学園大学

affil-num=2
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科
en-keyword=ビオスとゾーエー (bios and zoé)
kn-keyword=ビオスとゾーエー (bios and zoé)
en-keyword=〈いのち〉の教育  (life-education)
kn-keyword=〈いのち〉の教育  (life-education)
en-keyword=発達段階 (development stages)
kn-keyword=発達段階 (development stages)
en-keyword=コミュニケーション的行為 (communicative action)
kn-keyword=コミュニケーション的行為 (communicative action)
en-keyword=討議 (Diskurs)
kn-keyword=討議 (Diskurs)
END

start-ver=1.4
cd-journal=joma
no-vol=129
cd-vols=
no-issue=1
article-no=
start-page=35
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170403
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A refractory cutaneous-rectovesical fistula complicated with abdominal actinomycosis successfully treated with antibiotic therapy
kn-title=抗菌化学療法で保存的に閉鎖した放線菌症による 難治性皮膚直腸膀胱瘻の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The patient was a 35-year-old Japanese man diagnosed with appendicitis with abscess formation. An appendectomy was performed, but a refractory surgical wound infection developed, and eventually a cutaneous-rectovesical fistula was detected. In a review of the first-time CT scan, a small high-density construction resembling a bone from a fish was detected in the ileum. The histopathological examination revealed granules of actinomyces. These findings suggested that abdominal actinomycosis due to intestinal mucosal breakage by the fish bone caused the secondary appendicitis, and that after the appendectomy, residual actinomyces caused the cutaneous-rectovesical fistula.
 After the diagnosis, total parenteral nutrition and a long-term administration of antibiotics improved the patient's clinical symptoms, and the fistula closed within a month. Antibiotics were administered for 6 months, and there has been no recurrence for 6-1/2 years. Because actinomycosis is difficult to diagnose based on the typical clinical features, a direct identification of the infecting organism from a tissue sample or from sulfur granules is required for the definitive diagnosis. Actinomyces is also known to cause fistula formation, and intestinal penetration caused by a fish bone may indicate abdominal actinomycosis. A rectovesical fistula requires surgical intervention in most cases, but in cases caused by abdominal actinomycosis, such a fistula may be cured by conservative therapy, as in our patient's case. It is important to consider the possibility of actinomycosis when a refractory rectovesical fistula is observed.
en-copyright=
kn-copyright=

en-aut-name=KatsuraYuki
en-aut-sei=Katsura
en-aut-mei=Yuki
kn-aut-name=桂佑貴
kn-aut-sei=桂
kn-aut-mei=佑貴
aut-affil-num=1
ORCID=

en-aut-name=MatsukawaHiroyoshi
en-aut-sei=Matsukawa
en-aut-mei=Hiroyoshi
kn-aut-name=松川啓義
kn-aut-sei=松川
kn-aut-mei=啓義
aut-affil-num=2
ORCID=

en-aut-name=KatoTakuya
en-aut-sei=Kato
en-aut-mei=Takuya
kn-aut-name=加藤卓也
kn-aut-sei=加藤
kn-aut-mei=卓也
aut-affil-num=3
ORCID=

en-aut-name=SugiharaMasahiro
en-aut-sei=Sugihara
en-aut-mei=Masahiro
kn-aut-name=杉原正大
kn-aut-sei=杉原
kn-aut-mei=正大
aut-affil-num=4
ORCID=

en-aut-name=OjimaYasutomo
en-aut-sei=Ojima
en-aut-mei=Yasutomo
kn-aut-name=小島康知
kn-aut-sei=小島
kn-aut-mei=康知
aut-affil-num=5
ORCID=

en-aut-name=ShiozakiShigehiro
en-aut-sei=Shiozaki
en-aut-mei=Shigehiro
kn-aut-name=塩崎滋弘
kn-aut-sei=塩崎
kn-aut-mei=滋弘
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital
kn-affil=広島市立広島市民病院　外科

affil-num=2
en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital
kn-affil=広島市立広島市民病院　外科

affil-num=3
en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital
kn-affil=広島市立広島市民病院　外科

affil-num=4
en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital
kn-affil=広島市立広島市民病院　外科

affil-num=5
en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital
kn-affil=広島市立広島市民病院　外科

affil-num=6
en-affil=Department of Surgery, Hiroshima City Hiroshima Citizens Hospital
kn-affil=広島市立広島市民病院　外科
en-keyword=放線菌症 (actinomycosis)
kn-keyword=放線菌症 (actinomycosis)
en-keyword=皮膚直腸膀胱瘻 (cutaneous-rectovesical fistula) 
kn-keyword=皮膚直腸膀胱瘻 (cutaneous-rectovesical fistula) 
en-keyword=急性虫垂炎 (appendicitis) 
kn-keyword=急性虫垂炎 (appendicitis) 
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20161227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ウイルスが誘導するマイクロRNA-29はMCL1発現抑制を介してヒト骨肉腫細胞における化学療法抵抗性を改善する
kn-title=Ablation of MCL1 expression by virally induced microRNA-29 reverses chemoresistance in human osteosarcomas
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OsakiShuhei
en-aut-sei=Osaki
en-aut-mei=Shuhei
kn-aut-name=尾﨑修平
kn-aut-sei=尾﨑
kn-aut-mei=修平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=
article-no=
start-page=5
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Ginkgo biloba α-fucosidase with activity towards plant complex type N-glycans containing the Lewis a epitope: Purification and characterization
en-subtitle=
kn-subtitle=
en-abstract=　銀杏種子から高分子量 （SDS-PAGE で120 kDa） を有し，α-フコース含有オリゴ糖に活性を示すα-フコシダーゼ（α-fucosidase Gb）を均一に精製した．ルイス a エピトープ含有 N-グリカンを基質とした場合，α-fucosidase Gb の至適 pH は 5.5 付近であることから，本酵素は液胞のような酸性環境で機能していることが示唆された．N‒末端アミノ酸配列が化学修飾のため同定できなかったため，本酵素が GH29 ファミリーに属するかどうかは不明である．α-Fucosidase Gb は，Lacto-N-fucopentaose IIIの α1,3-フコース残基やルイス a エピトープ含有の植物複合型N-グリカンのα1,4-フコース残基を加水分解することから，α-フコース含有オリゴ糖やN 型糖タンパク質の分解プロセスに関与することが示唆された．
kn-abstract=　We have identified, and purified to homogeneity, a high molecular weight Ginkgo biloba α-fucosidase (α-fucosidase Gb, 120 kDa estimated by SDS‒PAGE) with activity against α-fucosylated oligosaccharides. When a Lewis a epitope-containing N-glycan was used as a substrate, α-fucosidase Gb showed optimum activity at approximately pH 5.5, suggesting that it functions in acidic environments such as the vacuole. It remains uncertain, however, whether this Ginkgo α-fucosidase belongs to the GH29 family, since its N-terminal sequence could not be determined, probably due to a chemical modification. α-Fucosidase Gb showed substantial activity towards the α1,3-fucosyl linkage in Lacto-N-fucopentaose III and an α1,4-fucosyl linkage in the Lewis a epitope found in plant complex type N-glycans, indicating an involvement in the degradation process of α-fucosylated oligosaccharides or N-glycoproteins.
en-copyright=
kn-copyright=

en-aut-name=ItanoSatsuki
en-aut-sei=Itano
en-aut-mei=Satsuki
kn-aut-name=板野紗月
kn-aut-sei=板野
kn-aut-mei=紗月
aut-affil-num=1
ORCID=

en-aut-name=MaedaMegumi
en-aut-sei=Maeda
en-aut-mei=Megumi
kn-aut-name=前田恵
kn-aut-sei=前田
kn-aut-mei=恵
aut-affil-num=2
ORCID=

en-aut-name=Md. Ziaur Rahman
en-aut-sei=Md. Ziaur Rahman
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KimuraYoshinobu
en-aut-sei=Kimura
en-aut-mei=Yoshinobu
kn-aut-name=木村吉伸
kn-aut-sei=木村
kn-aut-mei=吉伸
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=2
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=3
en-affil=Institute of Food and Radiation Biology, Atomic Energy Research Establishment, Bangladesh Atomic Energy Commission
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
en-keyword=α-fucosidase
kn-keyword=α-fucosidase
en-keyword=plant N-glycan
kn-keyword=plant N-glycan
en-keyword=N-glycan degradation
kn-keyword=N-glycan degradation
en-keyword=Ginkgo biloba
kn-keyword=Ginkgo biloba
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=電気化学的呼吸量測定による豚胚の客観的評価と胚移植による種豚生産システムの開発に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SakagamiNobutada
en-aut-sei=Sakagami
en-aut-mei=Nobutada
kn-aut-name=坂上信忠
kn-aut-sei=坂上
kn-aut-mei=信忠
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=マイクロ波表面波プラズマ化学気相成長法を用いたグラフェンおよびアモルファスカーボン膜の成長と物性評価
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IchimuraSusumu
en-aut-sei=Ichimura
en-aut-mei=Susumu
kn-aut-name=市村進
kn-aut-sei=市村
kn-aut-mei=進
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=3
article-no=
start-page=207
end-page=212
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20161201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Long-term survival of two patients with esophageal neuroendocrine carcinoma who underwent multidisciplinary therapy
kn-title=集学的治療により長期生存が得られた食道神経内分泌癌の2 例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　Esophageal neuroendocrine carcinoma （ECC） is rare and has a poor prognosis when presenting with vascular invasion and distant metastasis from an early stage. Multidisciplinary therapy with surgery, chemotherapy, and radiation therapy may prolong survival in patients with advanced ECC, but there is as yet no standard therapy for advanced ECC. We treated two patients who have achieved long-term survival （＞ 4 years） who underwent multidisciplinary therapy, including chemotherapy, for ECC. Our experience with these two cases suggests that multidisciplinary therapy, including chemotherapy, may be effective for treating ECC at an advanced stage.
en-copyright=
kn-copyright=

en-aut-name=GotodaTatsuhiro
en-aut-sei=Gotoda
en-aut-mei=Tatsuhiro
kn-aut-name=後藤田達洋
kn-aut-sei=後藤田
kn-aut-mei=達洋
aut-affil-num=1
ORCID=

en-aut-name=KawanoSeiji
en-aut-sei=Kawano
en-aut-mei=Seiji
kn-aut-name=川野誠司
kn-aut-sei=川野
kn-aut-mei=誠司
aut-affil-num=2
ORCID=

en-aut-name=KonoYoshiyasu
en-aut-sei=Kono
en-aut-mei=Yoshiyasu
kn-aut-name=河野吉泰
kn-aut-sei=河野
kn-aut-mei=吉泰
aut-affil-num=3
ORCID=

en-aut-name=MiuraKou
en-aut-sei=Miura
en-aut-mei=Kou
kn-aut-name=三浦公
kn-aut-sei=三浦
kn-aut-mei=公
aut-affil-num=4
ORCID=

en-aut-name=KanzakiHiromitsu
en-aut-sei=Kanzaki
en-aut-mei=Hiromitsu
kn-aut-name=神崎洋光
kn-aut-sei=神崎
kn-aut-mei=洋光
aut-affil-num=5
ORCID=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=岩室雅也
kn-aut-sei=岩室
kn-aut-mei=雅也
aut-affil-num=6
ORCID=

en-aut-name=KawaharaYoshiro
en-aut-sei=Kawahara
en-aut-mei=Yoshiro
kn-aut-name=河原祥朗
kn-aut-sei=河原
kn-aut-mei=祥朗
aut-affil-num=7
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=田中健大
kn-aut-sei=田中
kn-aut-mei=健大
aut-affil-num=8
ORCID=

en-aut-name=YoshinoTadashi
en-aut-sei=Yoshino
en-aut-mei=Tadashi
kn-aut-name=吉野正
kn-aut-sei=吉野
kn-aut-mei=正
aut-affil-num=9
ORCID=

en-aut-name=ShirakawadYasuhiro
en-aut-sei=Shirakawad
en-aut-mei=Yasuhiro
kn-aut-name=白川靖博
kn-aut-sei=白川
kn-aut-mei=靖博
aut-affil-num=10
ORCID=

en-aut-name=TabataMasahiro
en-aut-sei=Tabata
en-aut-mei=Masahiro
kn-aut-name=田端雅弘
kn-aut-sei=田端
kn-aut-mei=雅弘
aut-affil-num=11
ORCID=

en-aut-name=TanimotoMitsune
en-aut-sei=Tanimoto
en-aut-mei=Mitsune
kn-aut-name=谷本光音
kn-aut-sei=谷本
kn-aut-mei=光音
aut-affil-num=12
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=岡田裕之
kn-aut-sei=岡田
kn-aut-mei=裕之
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=7
en-affil=Department of Endoscopy, Okayama University Hospital
kn-affil=岡山大学病院　光学医療診療部

affil-num=8
en-affil=Department of Pathology, , Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　病理学（腫瘍病理）

affil-num=9
en-affil=Department of Pathology, , Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　病理学（腫瘍病理）

affil-num=10
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化管外科学

affil-num=11
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍内科学

affil-num=12
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍内科学

affil-num=13
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学
en-keyword=食道神経内分泌腫瘍（esophageal neuroendocrine carcinoma）
kn-keyword=食道神経内分泌腫瘍（esophageal neuroendocrine carcinoma）
en-keyword=小細胞癌（small cell carcinoma）
kn-keyword=小細胞癌（small cell carcinoma）
en-keyword=集学的治療（multidisciplinary therapy）
kn-keyword=集学的治療（multidisciplinary therapy）
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=2
article-no=
start-page=117
end-page=120
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Incisional hernia repair after wide excision of the iliac bone
kn-title=腸骨広範囲切除術後に発生した腹壁瘢痕ヘルニアに対しメッシュ修復術を行った一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　The patient was a 46-year old Japanese female who had undergone wide excision of the iliac bone and hip transposition at our institute's orthopedics department 2 years earlier. She presented with a growing incisional hernia and was transferred to our gastroenterological surgery department for surgical treatment. We planned a mesh repair for the incisional hernia, which protruded over the right iliac bone. The dimensions of the abdominal defect were 15×9 cm, and we used prolene mesh to repair the defect. The mesh was fixed at the inner part of the iliac bone, folded back at the iliac horn and fixed to the abdominal oblique muscles. The postoperative course was smooth, and recurrence was not seen at 3.5 years after the operation. An incisional hernia as seen in this patient's case is very rare, but we found that the underlay technique and prolene mesh were very useful for the three-dimensional hernia repair.
en-copyright=
kn-copyright=

en-aut-name=TsukudaKazunori
en-aut-sei=Tsukuda
en-aut-mei=Kazunori
kn-aut-name=佃和憲
kn-aut-sei=佃
kn-aut-mei=和憲
aut-affil-num=1
ORCID=

en-aut-name=AsanoHiroaki
en-aut-sei=Asano
en-aut-mei=Hiroaki
kn-aut-name=浅野博昭
kn-aut-sei=浅野
kn-aut-mei=博昭
aut-affil-num=2
ORCID=

en-aut-name=MandaiYasuhiro
en-aut-sei=Mandai
en-aut-mei=Yasuhiro
kn-aut-name=万代康弘
kn-aut-sei=万代
kn-aut-mei=康弘
aut-affil-num=3
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Minimally Invasive Therapy Center, Okayama University Hospital
kn-affil=岡山大学病院　低侵襲治療センター

affil-num=2
en-affil=Minimally Invasive Therapy Center, Okayama University Hospital
kn-affil=岡山大学病院　低侵襲治療センター

affil-num=3
en-affil=Center of the Development and Health Care Education, Okayama University
kn-affil=岡山大学医療教育統合開発センター

affil-num=4
en-affil=Department of Gastrointestinal Sugery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬総合研究科　消化器外科学
en-keyword=腹壁瘢痕ヘルニア（incisional hernia）
kn-keyword=腹壁瘢痕ヘルニア（incisional hernia）
en-keyword=腸骨軟骨肉腫（chondrosarcoma of the iliac bone）
kn-keyword=腸骨軟骨肉腫（chondrosarcoma of the iliac bone）
en-keyword=腸骨広範囲切除術（wide excision of the iliac bone）
kn-keyword=腸骨広範囲切除術（wide excision of the iliac bone）
en-keyword=プロリーンメッシュ（prolene mesh）
kn-keyword=プロリーンメッシュ（prolene mesh）
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=スパッタ法により作製されたナノアイランド構造を有する非晶質酸化ニオブの光電気化学特性と構造解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SajikiGo
en-aut-sei=Sajiki
en-aut-mei=Go
kn-aut-name=桟敷剛
kn-aut-sei=桟敷
kn-aut-mei=剛
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=置換ピセンの合成物理化学的性質
kn-title=Synthesis and Physicochemical Properties of Substituted Picenes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ChenXi-chao
en-aut-sei=Chen
en-aut-mei=Xi-chao
kn-aut-name=陳璽朝
kn-aut-sei=陳
kn-aut-mei=璽朝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=
article-no=
start-page=131
end-page=153
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Preliminary Investigation for the Construction of Teaching Materials for Studying Muslim Culture : Japanese Students' Responses to the Trial Version of Muslim Culture Assimilators
kn-title=ムスリム文化学習の教材構成に向けた予備調査： 日本人学生を対象とした文化アシミレーター試作版への反応
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakanoSachiko
en-aut-sei=Nakano
en-aut-mei=Sachiko
kn-aut-name=中野祥子
kn-aut-sei=中野
kn-aut-mei=祥子
aut-affil-num=1
ORCID=

en-aut-name=TanakaTomoko
en-aut-sei=Tanaka
en-aut-mei=Tomoko
kn-aut-name=田中共子
kn-aut-sei=田中
kn-aut-mei=共子
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科

affil-num=2
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=1
article-no=
start-page=21
end-page=25
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of mucinous adenocarcinoma of the duodenum and literature review of 16 cases reported in Japan
kn-title=原発性十二指腸粘液癌の一例― 本邦報告16例の検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　Primary mucinous adenocarcinoma of the duodenum is rare. Here we report a case we recently encountered, and we review 16 cases reported in Japan. An 82-year-old Japanese woman was admitted to our hospital complaining of abdominal pain and heartburn. An endoscopic examination revealed a Type 2 tumor in the descending limb of the duodenum, and endoscopically obtained specimens revealed a poorly differentiated adenocarcinoma. We performed a curative pancreatoduodenectomy with lymph node resection, and the surgical specimen revealed that the duodenum was the primary site of the mucinous adenocarcinoma. The patient is currently alive ＞ 1 year after the operation without any evidence of recurrence. Of the 16 patients reviewed, all patients had advanced tumors those depth were T3-T4. 9 patients had lymph node metastasis and 4 patients had peritoneal dissemination at the time of surgery. Since mucinous adenocarcinoma of the duodenum is often progressive cancer at a diagnosis, which is tend to have a worse prognosis than other histological types.
en-copyright=
kn-copyright=

en-aut-name=HamanoIkumi
en-aut-sei=Hamano
en-aut-mei=Ikumi
kn-aut-name=浜野郁美
kn-aut-sei=浜野
kn-aut-mei=郁美
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoYusuke
en-aut-sei=Matsumoto
en-aut-mei=Yusuke
kn-aut-name=松本祐介
kn-aut-sei=松本
kn-aut-mei=祐介
aut-affil-num=2
ORCID=

en-aut-name=EndoYoshikatsu
en-aut-sei=Endo
en-aut-mei=Yoshikatsu
kn-aut-name=遠藤芳克
kn-aut-sei=遠藤
kn-aut-mei=芳克
aut-affil-num=3
ORCID=

en-aut-name=WatanabeNaoki
en-aut-sei=Watanabe
en-aut-mei=Naoki
kn-aut-name=渡邊直樹
kn-aut-sei=渡邊
kn-aut-mei=直樹
aut-affil-num=4
ORCID=

en-aut-name=KaiKyouhei
en-aut-sei=Kai
en-aut-mei=Kyouhei
kn-aut-name=甲斐恭平
kn-aut-sei=甲斐
kn-aut-mei=恭平
aut-affil-num=5
ORCID=

en-aut-name=SatoShizou
en-aut-sei=Sato
en-aut-mei=Shizou
kn-aut-name=佐藤四三
kn-aut-sei=佐藤
kn-aut-mei=四三
aut-affil-num=6
ORCID=

en-aut-name=WaniYoji
en-aut-sei=Wani
en-aut-mei=Yoji
kn-aut-name=和仁洋治
kn-aut-sei=和仁
kn-aut-mei=洋治
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=2
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=3
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=4
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=5
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=6
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=7
en-affil=
kn-affil=姫路赤十字病院　病理診断科
en-keyword=原発性十二指腸癌（primary duodenal cancer）
kn-keyword=原発性十二指腸癌（primary duodenal cancer）
en-keyword=粘液癌（mucinous carcinoma）
kn-keyword=粘液癌（mucinous carcinoma）
en-keyword=膵頭十二指腸切除（pancreatoduodenectomy）
kn-keyword=膵頭十二指腸切除（pancreatoduodenectomy）
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20151231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=エストロゲン陽性乳癌において術前化学療法にホルモン療法を同時併用するかどうか：ランダム化多施設第2相試験
kn-title=Neoadjuvant Chemotherapy with or without Concurrent Hormone Therapy in Estrogen Receptor -Positive Breast Cancer: NACED-Randomized Multicenter Phase Ⅱ Trial
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SugiuKumi
en-aut-sei=Sugiu
en-aut-mei=Kumi
kn-aut-name=杉生久実
kn-aut-sei=杉生
kn-aut-mei=久実
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院
END

start-ver=1.4
cd-journal=joma
no-vol=22
cd-vols=
no-issue=
article-no=
start-page=49
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030315
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=《L'homme est perissable.....》 -sur un passage de la Lettre XC d'Obermann-
kn-title=「人間は滅ぶものである……」 -『オーベルマン』第90信の一筋について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HagiwaraNaoyuki
en-aut-sei=Hagiwara
en-aut-mei=Naoyuki
kn-aut-name=萩原直幸
kn-aut-sei=萩原
kn-aut-mei=直幸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=
article-no=
start-page=75
end-page=92
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020315
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Vendange a Meterville -sur la reception de la Lettre IX d'Obermann-
kn-title=メテルヴィルの葡萄摘み ―「オーベルマン」第9信の受容について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HagiwaraNaoyuki
en-aut-sei=Hagiwara
en-aut-mei=Naoyuki
kn-aut-name=萩原直幸
kn-aut-sei=萩原
kn-aut-mei=直幸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=127
cd-vols=
no-issue=3
article-no=
start-page=213
end-page=218
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20151201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case report of giant ectopic pheochromocytoma conversion therapy with radioisotope therapy and chemotherapy followed by curative resection
kn-title=術前内照射および化学療法が著効し,根治切除し得た巨大異所性褐色細胞腫の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 46-year-old man was found to be positive for occult blood at a medical checkup and was revealed to have a 14-cm tumor on the right side of abdominal aorta by a subsequent abdominal CT scan. The endocrinology laboratory data showed elevations in the levels of serum noradrenaline, and ectopic pheochromocytoma was suspected.
 The tumor was compressing the inferior vena cava and portal vein, the superior mesenteric artery and the pancreas. Since it would be difficult to cure by operation, neoadjuvant therapy was started using radioisotope therapy by I-131 metaiodobenzylguanidine (131I-MIBG) and chemotherapy (CVD therapy ; cyclophosphamide, vincristine, dacarbazine). He was treated with three courses of radioisotope therapy and 16 courses of chemotherapy, which significantly reduced the tumor size. This made radical resection possible ; we were able to avoid the merger excision of great vessels and other organs.
 On pathological and immunopathological findings, the tumor was diagnosed as ectopic　pheochromocytoma. Regarding the safety and curability of the treatment, neoadjuvant therapy may be useful in treating very large tumors that show invasion of other organs.
en-copyright=
kn-copyright=

en-aut-name=YasuiKazuya
en-aut-sei=Yasui
en-aut-mei=Kazuya
kn-aut-name=安井和也
kn-aut-sei=安井
kn-aut-mei=和也
aut-affil-num=1
ORCID=

en-aut-name=UmedaYuzo
en-aut-sei=Umeda
en-aut-mei=Yuzo
kn-aut-name=楳田祐三
kn-aut-sei=楳田
kn-aut-mei=祐三
aut-affil-num=2
ORCID=

en-aut-name=KumanoKenjiro
en-aut-sei=Kumano
en-aut-mei=Kenjiro
kn-aut-name=熊野健二郎
kn-aut-sei=熊野
kn-aut-mei=健二郎
aut-affil-num=3
ORCID=

en-aut-name=TabataMasahiro
en-aut-sei=Tabata
en-aut-mei=Masahiro
kn-aut-name=田端雅弘
kn-aut-sei=田端
kn-aut-mei=雅弘
aut-affil-num=4
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=大塚文男
kn-aut-sei=大塚
kn-aut-mei=文男
aut-affil-num=5
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=6
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科
en-keyword=異所性褐色細胞腫（ectopic pheochromocytoma）
kn-keyword=異所性褐色細胞腫（ectopic pheochromocytoma）
en-keyword=化学療法（chemo therapy）
kn-keyword=化学療法（chemo therapy）
en-keyword=131I-MIBG
kn-keyword=131I-MIBG
END

start-ver=1.4
cd-journal=joma
no-vol=127
cd-vols=
no-issue=3
article-no=
start-page=187
end-page=195
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20151201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Basic and clinical research regarding vascular endothelial function
kn-title=血管内皮機能を対象にした基礎および臨床医学研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TsukaharaHirokazu
en-aut-sei=Tsukahara
en-aut-mei=Hirokazu
kn-aut-name=塚原宏一
kn-aut-sei=塚原
kn-aut-mei=宏一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科
en-keyword=アルギニン代謝
kn-keyword=アルギニン代謝
en-keyword=一酸化窒素
kn-keyword=一酸化窒素
en-keyword=ガス生物学
kn-keyword=ガス生物学
en-keyword=血管内皮学
kn-keyword=血管内皮学
en-keyword=酸化ストレス
kn-keyword=酸化ストレス
END

start-ver=1.4
cd-journal=joma
no-vol=127
cd-vols=
no-issue=2
article-no=
start-page=151
end-page=154
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug interaction (33. Combination with antimicrobial agents)
kn-title=薬物相互作用（33―抗菌薬の薬物相互作用）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TasakaKen
en-aut-sei=Tasaka
en-aut-mei=Ken
kn-aut-name=田坂健
kn-aut-sei=田坂
kn-aut-mei=健
aut-affil-num=1
ORCID=

en-aut-name=ShiraishiNaoko
en-aut-sei=Shiraishi
en-aut-mei=Naoko
kn-aut-name=白石奈緒子
kn-aut-sei=白石
kn-aut-mei=奈緒子
aut-affil-num=2
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=北村佳久
kn-aut-sei=北村
kn-aut-mei=佳久
aut-affil-num=3
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=千堂年昭
kn-aut-sei=千堂
kn-aut-mei=年昭
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院

affil-num=2
en-affil=
kn-affil=岡山大学病院

affil-num=3
en-affil=
kn-affil=岡山大学病院

affil-num=4
en-affil=
kn-affil=岡山大学病院
END

start-ver=1.4
cd-journal=joma
no-vol=127
cd-vols=
no-issue=2
article-no=
start-page=127
end-page=132
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A prospective cohort study to define the clinical and pathological features of lung cancers harboring HER2 gene aberrations (the HER2-CS Study) and a phase II study of trastuzumab emtansine (recombinant) in patients with HER2-positive non-small cell lung cancer who recurred, progressed after standard chemotherapy, or were primarily refractory to standard chemotherapy
kn-title=HER2異常等の低頻度の分子異常を有する非小細胞肺癌の臨床病理学的特徴を明らかにするための前向き観察研究（HER2-CS Study）と標準化学療法後再発・増悪または標準化学療法不応性のHER2陽性非小細胞肺癌患者を対象としたトラスツズマブエムタンシン（遺伝子組換え）の第2相試験
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KiuraKatsuyuki
en-aut-sei=Kiura
en-aut-mei=Katsuyuki
kn-aut-name=木浦勝行
kn-aut-sei=木浦
kn-aut-mei=勝行
aut-affil-num=1
ORCID=

en-aut-name=HottaKatsuyuki
en-aut-sei=Hotta
en-aut-mei=Katsuyuki
kn-aut-name=堀田勝幸
kn-aut-sei=堀田
kn-aut-mei=勝幸
aut-affil-num=2
ORCID=

en-aut-name=SatoAkiko
en-aut-sei=Sato
en-aut-mei=Akiko
kn-aut-name=佐藤晃子
kn-aut-sei=佐藤
kn-aut-mei=晃子
aut-affil-num=3
ORCID=

en-aut-name=OhashiKadoaki
en-aut-sei=Ohashi
en-aut-mei=Kadoaki
kn-aut-name=大橋圭明
kn-aut-sei=大橋
kn-aut-mei=圭明
aut-affil-num=4
ORCID=

en-aut-name=NinomiyaTakashi
en-aut-sei=Ninomiya
en-aut-mei=Takashi
kn-aut-name=二宮崇
kn-aut-sei=二宮
kn-aut-mei=崇
aut-affil-num=5
ORCID=

en-aut-name=MinnamiDaisuke
en-aut-sei=Minnami
en-aut-mei=Daisuke
kn-aut-name=南大輔
kn-aut-sei=南
kn-aut-mei=大輔
aut-affil-num=6
ORCID=

en-aut-name=TabataMasahiro
en-aut-sei=Tabata
en-aut-mei=Masahiro
kn-aut-name=田端雅弘
kn-aut-sei=田端
kn-aut-mei=雅弘
aut-affil-num=7
ORCID=

en-aut-name=KuboToshio
en-aut-sei=Kubo
en-aut-mei=Toshio
kn-aut-name=久保寿夫
kn-aut-sei=久保
kn-aut-mei=寿夫
aut-affil-num=8
ORCID=

en-aut-name=KatoYuka
en-aut-sei=Kato
en-aut-mei=Yuka
kn-aut-name=加藤有加
kn-aut-sei=加藤
kn-aut-mei=有加
aut-affil-num=9
ORCID=

en-aut-name=HirataTaizo
en-aut-sei=Hirata
en-aut-mei=Taizo
kn-aut-name=平田泰三
kn-aut-sei=平田
kn-aut-mei=泰三
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院

affil-num=2
en-affil=
kn-affil=岡山大学病院

affil-num=3
en-affil=
kn-affil=岡山大学病院

affil-num=4
en-affil=
kn-affil=岡山大学病院

affil-num=5
en-affil=
kn-affil=岡山大学病院

affil-num=6
en-affil=
kn-affil=岡山大学病院

affil-num=7
en-affil=
kn-affil=岡山大学病院

affil-num=8
en-affil=
kn-affil=岡山大学病院

affil-num=9
en-affil=
kn-affil=岡山大学病院

affil-num=10
en-affil=
kn-affil=岡山大学病院
en-keyword=臨床研究中核病院
kn-keyword=臨床研究中核病院
en-keyword=国立研究開発法人日本医療研究開発機構
kn-keyword=国立研究開発法人日本医療研究開発機構
en-keyword=文部科学省橋渡し研究加速ネットワークプログラム
kn-keyword=文部科学省橋渡し研究加速ネットワークプログラム
en-keyword=HER2-CS study
kn-keyword=HER2-CS study
en-keyword=trastuzumab emtansine
kn-keyword=trastuzumab emtansine
END

start-ver=1.4
cd-journal=joma
no-vol=127
cd-vols=
no-issue=2
article-no=
start-page=123
end-page=126
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of laparoscopic and endoscopic cooperative surgery for sigmoidovesical fistula
kn-title=腹腔鏡内視鏡合同手術（Laparoscopy and Endoscopy Cooperative Surgery；LECS） を施行したＳ状結腸膀胱瘻の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We performed laparoscopic and endoscopic cooperative surgery (LECS) for partial colectomy with partial cystectomy in an 80-year-old woman with sigmoidovesical fistula secondary to sigmoid diverticulitis. LECS was designed for local resection of the stomach for gastric submucosal tumors using the endoscopic submucosal dissection (ESD) technique. While conventional open abdominal surgery is very invasive, LECS has enabled surgeons to perform minimally invasive surgery. Although there have been no reported cases in which the bladder was laparoscopically resected after sigmoidovesical fistula division, we were able to safely resect the fistula and preserve the urethral opening by performing laparoscopic and cystoscopic cooperative surgery. There are no previously reported cases in which LECS was performed for partial sigmoidectomy and partial cystectomy ; therefore, we report this as a valuable case, with a review of the literature. We hope that further studies involving more patients will lead to the establishment of this procedure.
en-copyright=
kn-copyright=

en-aut-name=KatoHiroshi
en-aut-sei=Kato
en-aut-mei=Hiroshi
kn-aut-name=加藤大
kn-aut-sei=加藤
kn-aut-mei=大
aut-affil-num=1
ORCID=

en-aut-name=OishiMasahiro
en-aut-sei=Oishi
en-aut-mei=Masahiro
kn-aut-name=大石正博
kn-aut-sei=大石
kn-aut-mei=正博
aut-affil-num=2
ORCID=

en-aut-name=KoderaMasahito
en-aut-sei=Kodera
en-aut-mei=Masahito
kn-aut-name=小寺正人
kn-aut-sei=小寺
kn-aut-mei=正人
aut-affil-num=3
ORCID=

en-aut-name=YamamuraMasao
en-aut-sei=Yamamura
en-aut-mei=Masao
kn-aut-name=山村方夫
kn-aut-sei=山村
kn-aut-mei=方夫
aut-affil-num=4
ORCID=

en-aut-name=IkedaHideaki
en-aut-sei=Ikeda
en-aut-mei=Hideaki
kn-aut-name=池田秀明
kn-aut-sei=池田
kn-aut-mei=秀明
aut-affil-num=5
ORCID=

en-aut-name=MizunoKenji
en-aut-sei=Mizuno
en-aut-mei=Kenji
kn-aut-name=水野憲治
kn-aut-sei=水野
kn-aut-mei=憲治
aut-affil-num=6
ORCID=

en-aut-name=TaniYuma
en-aut-sei=Tani
en-aut-mei=Yuma
kn-aut-name=谷悠真
kn-aut-sei=谷
kn-aut-mei=悠真
aut-affil-num=7
ORCID=

en-aut-name=YamashitaYutaka
en-aut-sei=Yamashita
en-aut-mei=Yutaka
kn-aut-name=山下裕
kn-aut-sei=山下
kn-aut-mei=裕
aut-affil-num=8
ORCID=

en-aut-name=HayataShunji
en-aut-sei=Hayata
en-aut-mei=Shunji
kn-aut-name=早田俊司
kn-aut-sei=早田
kn-aut-mei=俊司
aut-affil-num=9
ORCID=

en-aut-name=KurashigeTakushi
en-aut-sei=Kurashige
en-aut-mei=Takushi
kn-aut-name=倉繁拓志
kn-aut-sei=倉繁
kn-aut-mei=拓志
aut-affil-num=10
ORCID=

en-aut-name=NishiyamaYasuhiro
en-aut-sei=Nishiyama
en-aut-mei=Yasuhiro
kn-aut-name=西山康弘
kn-aut-sei=西山
kn-aut-mei=康弘
aut-affil-num=11
ORCID=

en-aut-name=NishikawaDaisuke
en-aut-sei=Nishikawa
en-aut-mei=Daisuke
kn-aut-name=西川大祐
kn-aut-sei=西川
kn-aut-mei=大祐
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=鳥取市立病院

affil-num=2
en-affil=
kn-affil=鳥取市立病院

affil-num=3
en-affil=
kn-affil=鳥取市立病院

affil-num=4
en-affil=
kn-affil=鳥取市立病院

affil-num=5
en-affil=
kn-affil=鳥取市立病院

affil-num=6
en-affil=
kn-affil=鳥取市立病院

affil-num=7
en-affil=
kn-affil=鳥取市立病院

affil-num=8
en-affil=
kn-affil=鳥取市立病院

affil-num=9
en-affil=
kn-affil=鳥取市立病院

affil-num=10
en-affil=
kn-affil=鳥取市立病院

affil-num=11
en-affil=
kn-affil=鳥取市立病院

affil-num=12
en-affil=
kn-affil=鳥取市立病院
en-keyword=結腸膀胱瘻（sigmoidovesical fistula）
kn-keyword=結腸膀胱瘻（sigmoidovesical fistula）
en-keyword=腹腔鏡内視鏡合同手術（laparoscopic and endoscopic cooperative surgery（LECS））
kn-keyword=腹腔鏡内視鏡合同手術（laparoscopic and endoscopic cooperative surgery（LECS））
END

start-ver=1.4
cd-journal=joma
no-vol=69
cd-vols=
no-issue=3
article-no=
start-page=145
end-page=153
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=201506
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Eosinophil Cationic Protein Shows Survival Effect on H9c2 Cardiac Myoblast Cells with Enhanced Phosphorylation of ERK and Akt/GSK-3β under Oxidative Stress
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis.
en-copyright=
kn-copyright=

en-aut-name=IshiiHiroko
en-aut-sei=Ishii
en-aut-mei=Hiroko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KamikawaShigeshi
en-aut-sei=Kamikawa
en-aut-mei=Shigeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HirohataSatoshi
en-aut-sei=Hirohata
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MizutaniAkifumi
en-aut-sei=Mizutani
en-aut-mei=Akifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AbeKoji
en-aut-sei=Abe
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SenoMasaharu
en-aut-sei=Seno
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OohashiToshitaka
en-aut-sei=Oohashi
en-aut-mei=Toshitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NinomiyaYoshifumi
en-aut-sei=Ninomiya
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine

affil-num=2
en-affil=
kn-affil=Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine

affil-num=3
en-affil=
kn-affil=Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine

affil-num=4
en-affil=
kn-affil=Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University

affil-num=5
en-affil=
kn-affil=Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,

affil-num=6
en-affil=
kn-affil=Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University

affil-num=7
en-affil=
kn-affil=Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine

affil-num=8
en-affil=
kn-affil=Departments of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine
en-keyword=ECP
kn-keyword=ECP
en-keyword=reactive oxygen species
kn-keyword=reactive oxygen species
en-keyword=Akt
kn-keyword=Akt
en-keyword=ERK
kn-keyword=ERK
END

start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=
article-no=
start-page=59
end-page=63
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=201504
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Institute of Laboratory Animal Research, Center for Animal Research and Education, Nagoya University
kn-title=名古屋大学動物実験支援センター東山動物実験施設
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The Institute of Laboratory Animal Research（ILAR）within the Center for Animal Research and Education (CARE), Nagoya University was established in July 2013. The aim of ILAR is to provide care for laboratory animals in safe and sanitary manner that enables researchers in the Nagoya University Higashiyama Campus to conduct proper experiments. We will now give an outline and
introduce the characteristics of the new ILAR.
en-copyright=
kn-copyright=

en-aut-name=ItohMariko
en-aut-sei=Itoh
en-aut-mei=Mariko
kn-aut-name=伊藤麻里子
kn-aut-sei=伊藤
kn-aut-mei=麻里子
aut-affil-num=1
ORCID=

en-aut-name=InagakiHideaki
en-aut-sei=Inagaki
en-aut-mei=Hideaki
kn-aut-name=稲垣秀晃
kn-aut-sei=稲垣
kn-aut-mei=秀晃
aut-affil-num=2
ORCID=

en-aut-name=MoriRarami
en-aut-sei=Mori
en-aut-mei=Rarami
kn-aut-name=森ララミ
kn-aut-sei=森
kn-aut-mei=ララミ
aut-affil-num=3
ORCID=

en-aut-name=TodaMayumi
en-aut-sei=Toda
en-aut-mei=Mayumi
kn-aut-name=戸田真弓
kn-aut-sei=戸田
kn-aut-mei=真弓
aut-affil-num=4
ORCID=

en-aut-name=AonoShuichi
en-aut-sei=Aono
en-aut-mei=Shuichi
kn-aut-name=青野修一
kn-aut-sei=青野
kn-aut-mei=修一
aut-affil-num=5
ORCID=

en-aut-name=SatoJun
en-aut-sei=Sato
en-aut-mei=Jun
kn-aut-name=佐藤純
kn-aut-sei=佐藤
kn-aut-mei=純
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=名古屋大学動物実験支援センター東山動物実験施設

affil-num=2
en-affil=
kn-affil=名古屋大学動物実験支援センター東山動物実験施設

affil-num=3
en-affil=
kn-affil=岡山大学名古屋大学動物実験支援センター東山動物実験施設大学院医歯薬学総合研究科・分子医化学分野

affil-num=4
en-affil=
kn-affil=名古屋大学動物実験支援センター東山動物実験施設

affil-num=5
en-affil=
kn-affil=名古屋大学動物実験支援センター東山動物実験施設

affil-num=6
en-affil=
kn-affil=名古屋大学動物実験支援センター東山動物実験施設
END

start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=
article-no=
start-page=55
end-page=58
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=201504
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunological identification of H+-coupled myo-inositol cotransporter in the lateral wall of the cochlea duct
kn-title=蝸牛管側壁におけるミオイノシトール輸送体タンパク質の発現
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamajiMayumi
en-aut-sei=Yamaji
en-aut-mei=Mayumi
kn-aut-name=山地真裕美
kn-aut-sei=山地
kn-aut-mei=真裕美
aut-affil-num=1
ORCID=

en-aut-name=InoueRisa
en-aut-sei=Inoue
en-aut-mei=Risa
kn-aut-name=井上理佐
kn-aut-sei=井上
kn-aut-mei=理佐
aut-affil-num=2
ORCID=

en-aut-name=EdamatsuMidori
en-aut-sei=Edamatsu
en-aut-mei=Midori
kn-aut-name=枝松緑
kn-aut-sei=枝松
kn-aut-mei=緑
aut-affil-num=3
ORCID=

en-aut-name=AndoMotonori
en-aut-sei=Ando
en-aut-mei=Motonori
kn-aut-name=安藤元紀
kn-aut-sei=安藤
kn-aut-mei=元紀
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室

affil-num=2
en-affil=
kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科・分子医化学分野

affil-num=4
en-affil=
kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=日本化学繊維工業の発展と日中経済関係の展開に関する歴史的研究 －クラレにおけるレーヨン、ビニロン、人工皮革の工業化と対中技術移転を事例として－
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujimotoMasayuki
en-aut-sei=Fujimoto
en-aut-mei=Masayuki
kn-aut-name=藤本雅之
kn-aut-sei=藤本
kn-aut-mei=雅之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=キノリン-2-カルボアルデヒド(ピリジン-2-カルボニル)ヒドラゾンを配位子としたルテニウム錯体の配位化学
kn-title=Coordination Chemistry of Ruthenium Complexes with Quinoline-2-carbaldehyde (Pyridine-2-carbonyl)hydrazone
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MoriAsami
en-aut-sei=Mori
en-aut-mei=Asami
kn-aut-name=森麻美
kn-aut-sei=森
kn-aut-mei=麻美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=27
end-page=45
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150326
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Japan Seen from Vietnam
kn-title=ベトナムから見た日本
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=LeThi Thu Ha
en-aut-sei=Le
en-aut-mei=Thi Thu Ha
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=フエ大学付属外国語大学日本語日本文化学部
END

start-ver=1.4
cd-journal=joma
no-vol=36
cd-vols=
no-issue=
article-no=
start-page=20
end-page=22
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=201502
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=新規化学物質管理規程による化学物質管理の強化について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=加瀬野悟
kn-aut-sei=加瀬野
kn-aut-mei=悟
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学環境管理センター
END

start-ver=1.4
cd-journal=joma
no-vol=36
cd-vols=
no-issue=
article-no=
start-page=3
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=201502
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=平成26 年度環境管理センター公開講演会「環境と人と化学物質」
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=川本克也
kn-aut-sei=川本
kn-aut-mei=克也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学環境管理センター
END

start-ver=1.4
cd-journal=joma
no-vol=127
cd-vols=
no-issue=1
article-no=
start-page=41
end-page=45
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A phase I trial of 100㎎/㎡ docetaxel in advanced or recurrent breast cancer patients
kn-title=アンメットメディカルニーズを克服するためのプロジェクト「進行・再発乳癌に対するドセタキセル100㎎/㎡の第Ⅰ相試験」
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HirataTaizo
en-aut-sei=Hirata
en-aut-mei=Taizo
kn-aut-name=平田泰三
kn-aut-sei=平田
kn-aut-mei=泰三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院　新医療研究開発センター
en-keyword=進行・再発乳癌
kn-keyword=進行・再発乳癌
en-keyword=ドセタキセル
kn-keyword=ドセタキセル
en-keyword=100㎎/㎡
kn-keyword=100㎎/㎡
en-keyword=医師主導治験
kn-keyword=医師主導治験
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=岡山大学方式人工網膜を挿入したRCSラットの行動実験と免疫組織化学的評価
kn-title=Behavior tests and immunohistochemical retinal response analyses in RCS rats with subretinal implantation of Okayama-University-type retinal prosthesis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=阿拉木斯
kn-aut-sei=阿拉木斯
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=157
cd-vols=
no-issue=
article-no=
start-page=33
end-page=42
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20141127
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Differences in the Chemical Education in Upper Secondary Level between Japan and Swiss German Zone - A Comparative Study between the Recent Textbooks in Basic Stage -
kn-title=日本とスイス-ドイツ語圏-の後期中等教育段階における化学教育 : 化学基礎教科書の比較考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　スイス−ドイツ語圏−のギムナジウムと日本の高等学校とにおける化学基礎に焦点を当
て，後期中等教育段階における化学教育の比較考察を行った。スイスの化学基礎は，重点化
学・補充化学とは種類が異なるとともに，それらの基礎，日本の化学基礎は，化学履修前の
基礎である。そもそも，学習指導要領などが指示しているスイスと日本の化学基礎は，履修
年限（３か１），単位数（６か２），指示する内容分野の違いから，大きく異なっていた。教
科書も，その目次からは，酸−塩基と酸化還元反応があることでは同じであるが，生化学，
環境化学の設定の有無で異なっていること，索引からは，スイスでは１／８，日本では１／
３程度しか重複（共通）していないことなどで，大きく異なっていることを明らかにした。
en-copyright=
kn-copyright=

en-aut-name=TanakaKenji
en-aut-sei=Tanaka
en-aut-mei=Kenji
kn-aut-name=田中賢二
kn-aut-sei=田中
kn-aut-mei=賢二
aut-affil-num=1
ORCID=

en-aut-name=TanakaKeita
en-aut-sei=Tanaka
en-aut-mei=Keita
kn-aut-name=田中啓太
kn-aut-sei=田中
kn-aut-mei=啓太
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科

affil-num=2
en-affil=
kn-affil=津市立久居西中学校
en-keyword=日本
kn-keyword=日本
en-keyword=スイス−ドイツ語圏
kn-keyword=スイス−ドイツ語圏
en-keyword=後期中等教育段階
kn-keyword=後期中等教育段階
en-keyword=化学教育
kn-keyword=化学教育
en-keyword=教科書比較
kn-keyword=教科書比較
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=
article-no=
start-page=103
end-page=109
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20141025
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=数学教育における異校種間の連携・接続の視点　―生徒の発想を引き出す学習内容の関連付けを支援する架橋教員とその働き―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=佐藤学
kn-aut-sei=佐藤
kn-aut-mei=学
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=椎名美穂子
kn-aut-sei=椎名
kn-aut-mei=美穂子
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=秋田大学教育文化学部

affil-num=2
en-affil=
kn-affil=秋田県教育庁義務教育課
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=
article-no=
start-page=94
end-page=102
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20141025
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=場合の数における児童の指向性思考からの考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=佐藤学
kn-aut-sei=佐藤
kn-aut-mei=学
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=椎名美穂子
kn-aut-sei=椎名
kn-aut-mei=美穂子
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=秋田大学教育文化学部

affil-num=2
en-affil=
kn-affil=秋田県教育庁義務教育課
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=6
article-no=
start-page=147
end-page=149
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=文献と臨床の橋わたし　がん化学療法を受けている患者に対する口腔内管理の意義
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=曽我賢彦
kn-aut-sei=曽我
kn-aut-mei=賢彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院 中央診療施設医療支援歯科治療部
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=2
article-no=
start-page=151
end-page=153
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Guideline for the treatment of acute exacerbations of COPD and chronic bronchitis
kn-title=慢性呼吸器疾患（COPD，気管支拡張症，陳旧性肺結核等）の気道感染症治療ガイドライン
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TanimotoYasushi
en-aut-sei=Tanimoto
en-aut-mei=Yasushi
kn-aut-name=谷本安
kn-aut-sei=谷本
kn-aut-mei=安
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=国立病院機構南岡山医療センター　呼吸器・アレルギー内科
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=2
article-no=
start-page=127
end-page=131
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Fermented persimmon extract (kaki-shibu) is useful as a standard for component analyses of persimmon phytobezoars
kn-title=柿胃石の成分分析における標準物質としての柿渋の有用性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The definite diagnosis of persimmon phytobezoar (i.e., diospyrobezoar) is often accomplished by a component analysis using infrared spectroscopy. However, no studies have been conducted to investigate which substance is the best as a standard for the component analysis. Here we analyzed tannic acid, Japanese persimmon (kaki), fermented persimmon extract (kaki-shibu), conventional dried persimmon, and dried persimmon smoked in sulfur (ampo-kaki) by infrared spectroscopy to determine which would be optimal as a component analysis standard. The spectrum between 1,600 to 600cm－1 of a persimmon phytobezoar was quite similar to the spectrum of kaki-shibu rather than that of tannic acid. Consequently, we conclude that kaki-shibu should be used as a standard for infrared spectroscopy analyses of persimmon phytobezoars.
en-copyright=
kn-copyright=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=岩室雅也
kn-aut-sei=岩室
kn-aut-mei=雅也
aut-affil-num=1
ORCID=

en-aut-name=OkamotoYuko
en-aut-sei=Okamoto
en-aut-mei=Yuko
kn-aut-name=岡本裕子
kn-aut-sei=岡本
kn-aut-mei=裕子
aut-affil-num=2
ORCID=

en-aut-name=MurataToshihiro
en-aut-sei=Murata
en-aut-mei=Toshihiro
kn-aut-name=村田年弘
kn-aut-sei=村田
kn-aut-mei=年弘
aut-affil-num=3
ORCID=

en-aut-name=KawaiYoshinari
en-aut-sei=Kawai
en-aut-mei=Yoshinari
kn-aut-name=河合良成
kn-aut-sei=河合
kn-aut-mei=良成
aut-affil-num=4
ORCID=

en-aut-name=ShirahaHidenori
en-aut-sei=Shiraha
en-aut-mei=Hidenori
kn-aut-name=白羽英則
kn-aut-sei=白羽
kn-aut-mei=英則
aut-affil-num=5
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=岡田裕之
kn-aut-sei=岡田
kn-aut-mei=裕之
aut-affil-num=6
ORCID=

en-aut-name=YamamotoKazuhide
en-aut-sei=Yamamoto
en-aut-mei=Kazuhide
kn-aut-name=山本和秀
kn-aut-sei=山本
kn-aut-mei=和秀
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学

affil-num=2
en-affil=
kn-affil=井原市立井原市民病院　内科

affil-num=3
en-affil=
kn-affil=尾道市立市民病院 外科

affil-num=4
en-affil=
kn-affil=尾道市立市民病院 消化器内科

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学

affil-num=6
en-affil=
kn-affil=岡山大学病院　光学医療診療部

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学
en-keyword=柿胃石（gastric phytobezoar）
kn-keyword=柿胃石（gastric phytobezoar）
en-keyword=タンニン酸（tannic acid）
kn-keyword=タンニン酸（tannic acid）
en-keyword=消化管異物（gastrointestinal foreign body）
kn-keyword=消化管異物（gastrointestinal foreign body）
en-keyword=成分分析（component analysis）
kn-keyword=成分分析（component analysis）
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=2
article-no=
start-page=103
end-page=107
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Induction therapy followed by surgery for non small-cell lung cancer
kn-title=非小細胞肺癌に対する術前治療後外科切除療法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=豊岡伸一
kn-aut-sei=豊岡
kn-aut-mei=伸一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　臨床遺伝子医療学
en-keyword=非小細胞肺癌
kn-keyword=非小細胞肺癌
en-keyword=導入療法
kn-keyword=導入療法
en-keyword=放射線化学療法
kn-keyword=放射線化学療法
en-keyword=外科切除
kn-keyword=外科切除
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=マイクロ化学プロセス用三方電磁弁の開発と応用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KadowakiNobuhiro
en-aut-sei=Kadowaki
en-aut-mei=Nobuhiro
kn-aut-name=門脇信傑
kn-aut-sei=門脇
kn-aut-mei=信傑
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=
article-no=
start-page=31
end-page=32
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=201402
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=化学物質管理状況監査について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=加瀬野悟
kn-aut-sei=加瀬野
kn-aut-mei=悟
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学環境管理センター
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=1
article-no=
start-page=39
end-page=43
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil
kn-title=術前DCF療法が著効した食道原発内分泌細胞癌の１切除例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　Esophageal endocrine cell carcinoma is extremely rare. We report a case of esophageal endocrine cell carcinoma showing histological complete response to neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (DCF). A 66-year-old man had been experiencing epigastralgia, and a type 2 tumor in the thoracic part of esophagus was detected by upper endoscopy. The biopsy showed endocrine cell carcinoma. PET/CT, endoscopy and an esophagogram showed that the patient had a 70-mm scaled type 2 tumor in the middle thoracic esophagus, and they also revealed lymph node metastases (no. 106recR). We diagnosed a cT3cN1cM0 cStage III tumor. With two courses of DCF treatment, both the primary tumor and lymph node metastases showed a partial response. We performed a subtotal esophagectomy with three-field lymph node dissection. The pathological examination of the resected specimens revealed no malignant cells in the esophagus or lymph nodes, and we concluded that the pathological effect of the DCF treatment was Grade 3.
en-copyright=
kn-copyright=

en-aut-name=MaedaNaoaki
en-aut-sei=Maeda
en-aut-mei=Naoaki
kn-aut-name=前田直見
kn-aut-sei=前田
kn-aut-mei=直見
aut-affil-num=1
ORCID=

en-aut-name=ShirakawaYasuhiro
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cd-journal=joma
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cd-vols=
no-issue=10
article-no=
start-page=1889
end-page=1897
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Angiogenesis plays an important role in tumor progression. Several reports have demonstrated that a disintegrin and metalloproteinase with thrombospondin motifs1 (ADAMTS1) inhibited angiogenesis via multiple mechanisms. The aim of this study was to investigate the effect of ADAMTS1 on endothelial cells in vitro and on tumor growth with regard to angiogenesis in vivo. We examined the effects of the transfection of ADAMTS1 using two constructs, full-length ADAMTS1 (full ADAMTS1) and catalytic domain-deleted ADAMTS1 (delta ADAMTS1). Transfection of both the full ADAMTS1 and delta ADAMTS1 gene constructs demonstrated the secretion of tagged-ADAMTS1 protein into the conditioned medium, so we examined the effects of ADAMTS1-containing conditioned medium on endothelial cells. Both types of conditioned media inhibited endothelial tube formation, and this effect was completely abolished after immunoprecipitation of the secreted protein from the medium. Both types of conditioned media also inhibited endothelial cell migration and proliferation. We then examined the impact of ADAMTS1 on endothelial cell apoptosis. Both conditioned media increased the number of Annexin V-positive endothelial cells and caspase-3 activity and this effect was attenuated when z-vad was added. These results indicated that ADAMTS1 induced endothelial cell apoptosis. We next examined the effects of ADAMTS1 gene transfer into tumor-bearing mice. Both full ADAMTS1 and delta ADAMTS1 significantly inhibited the subcutaneous tumor growth. Collectively, our results demonstrated that ADAMTS1 gene transfer inhibited angiogenesis in vitro and in vivo, likely as a result of the induction of endothelial cell apoptosis by ADAMTS1 that occurs independent of the protease activity.
en-copyright=
kn-copyright=

en-aut-name=ObikaMasanari
en-aut-sei=Obika
en-aut-mei=Masanari
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OgawaHiroko
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en-aut-mei=Hiroko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakahashiKatsuyuki
en-aut-sei=Takahashi
en-aut-mei=Katsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=LiJiayi
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HatipogluOmer Faruk
en-aut-sei=Hatipoglu
en-aut-mei=Omer Faruk
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=CilekMehmet Zeynel
en-aut-sei=Cilek
en-aut-mei=Mehmet Zeynel
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiyoshiToru
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=InagakiJunko
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OhtsukiTakashi
en-aut-sei=Ohtsuki
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KusachiShozo
en-aut-sei=Kusachi
en-aut-mei=Shozo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NinomiyaYoshifumi
en-aut-sei=Ninomiya
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HirohataSatoshi
en-aut-sei=Hirohata
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem

affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem

affil-num=3
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem

affil-num=4
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem

affil-num=5
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem

affil-num=6
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem

affil-num=7
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem

affil-num=8
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem

affil-num=9
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem

affil-num=10
en-affil=
kn-affil=Okayama Univ, Grad Sch Hlth Sci, Dept Med Technol

affil-num=11
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem

affil-num=12
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Biol & Biochem
END

start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=4
article-no=
start-page=271
end-page=281
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199103
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Application of DNA Repair-Deficient Mutants of Yeast Saccharomyces cerevisiae for Genetic Toxicity Testing of Chemicals
kn-title=酵母Saccharomyces cerevisiaeのDNA修復機能欠損株を用いた化学物質の遺伝毒性評価への利用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AoyamaIsao
en-aut-sei=Aoyama
en-aut-mei=Isao
kn-aut-name=青山勳
kn-aut-sei=青山
kn-aut-mei=勳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=153
cd-vols=
no-issue=
article-no=
start-page=127
end-page=138
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130725
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Research on the Physics Education in the Lower Secondary Level in Swiss German Zone by Analysis of a Science Textbook
kn-title=スイス－ドイツ語圏－の前期中等教育段階における物理教育―科学(理科)教科書の分析―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=スイス−ドイツ語圏−の前期中等教育段階に焦点を当て，学習指導要領，教科書などに基
づき，物理教育の現状分析を行った。教科Naturlehre科学（理科）のもとに分野物理が位置
づけられている。学習指導要領で言及していることに対応して科学教科書も，物理，生物，
化学以外の第４の分野一般（その他）を，節単位で準備している。物理分野の節数や索引数
は，生物分野より少なく，化学分野より多かった。索引数の違いは，それぞれ，電気＞力＞
その他＞原子・核＞光＞熱＞音；人体＞動物＞植物＞その他＞一般生物；無機化学＞有機化
学＞その他＞物理化学であり，その他の割合では，生物と化学に比べて，物理は小さいこと，
また，活動・発展・追加の節が準備されている割合が最も少なく，人名索引数が最も多いと
いう特徴などを見いだした。
en-copyright=
kn-copyright=

en-aut-name=TanakaKenji
en-aut-sei=Tanaka
en-aut-mei=Kenji
kn-aut-name=田中賢二
kn-aut-sei=田中
kn-aut-mei=賢二
aut-affil-num=1
ORCID=

en-aut-name=TanakaKenta
en-aut-sei=Tanaka
en-aut-mei=Kenta
kn-aut-name=田中啓太
kn-aut-sei=田中
kn-aut-mei=啓太
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
en-keyword=スイス－ドイツ語圏
kn-keyword=スイス－ドイツ語圏
en-keyword=前期中等教育段階
kn-keyword=前期中等教育段階
en-keyword=物理教育
kn-keyword=物理教育
en-keyword=教科書
kn-keyword=教科書
en-keyword=現状分析
kn-keyword=現状分析
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=好熱性シアノバクテリアサーモシネココッカス・ブルカヌス由来光化学系IIに関する構造生物学的,生物物理学的研究
kn-title=Structural and Biophysical Studies of Photosystem II from a Thermophilic Cyanobacterium Thermosynechococcus vulcanus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Hammado Mekky KouaFaisal
en-aut-sei=Hammado Mekky Koua
en-aut-mei=Faisal
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=星間化学・大気化学で重要なイオン・ラジカル種の振動・回転スペクトル研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HujimoriRyuji
en-aut-sei=Hujimori
en-aut-mei=Ryuji
kn-aut-name=藤森隆彰
kn-aut-sei=藤森
kn-aut-mei=隆彰
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=2
article-no=
start-page=163
end-page=167
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug interaction (27. anti-emetics during anti-cancer chemotherapy)
kn-title=薬物相互作用（27―がん化学療法における制吐剤の薬物相互作用）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KurataYasuko
en-aut-sei=Kurata
en-aut-mei=Yasuko
kn-aut-name=蔵田靖子
kn-aut-sei=蔵田
kn-aut-mei=靖子
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraSatoko
en-aut-sei=Fujiwara
en-aut-mei=Satoko
kn-aut-name=藤原聡子
kn-aut-sei=藤原
kn-aut-mei=聡子
aut-affil-num=2
ORCID=

en-aut-name=KajizonoMakoto
en-aut-sei=Kajizono
en-aut-mei=Makoto
kn-aut-name=鍛治園誠
kn-aut-sei=鍛治園
kn-aut-mei=誠
aut-affil-num=3
ORCID=

en-aut-name=AoyagiMegumu
en-aut-sei=Aoyagi
en-aut-mei=Megumu
kn-aut-name=青柳恵
kn-aut-sei=青柳
kn-aut-mei=恵
aut-affil-num=4
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=北村佳久
kn-aut-sei=北村
kn-aut-mei=佳久
aut-affil-num=5
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=千堂年昭
kn-aut-sei=千堂
kn-aut-mei=年昭
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院 薬剤部

affil-num=2
en-affil=
kn-affil=岡山大学病院 薬剤部

affil-num=3
en-affil=
kn-affil=岡山大学病院 薬剤部

affil-num=4
en-affil=
kn-affil=岡山大学病院 薬剤部

affil-num=5
en-affil=
kn-affil=岡山大学病院 薬剤部

affil-num=6
en-affil=
kn-affil=岡山大学病院 薬剤部
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=2
article-no=
start-page=145
end-page=152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Molecular targeted therapies and gastroenterological neoplasia
kn-title=消化器がんと分子標的治療薬
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NagasakaTakeshi
en-aut-sei=Nagasaka
en-aut-mei=Takeshi
kn-aut-name=永坂岳司
kn-aut-sei=永坂
kn-aut-mei=岳司
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器外科学
en-keyword=消化器がん
kn-keyword=消化器がん
en-keyword=分子標的薬
kn-keyword=分子標的薬
en-keyword=化学療法
kn-keyword=化学療法
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=2
article-no=
start-page=103
end-page=107
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B cell characteristics
kn-title=十二指腸濾胞性リンパ腫はAIDの発現を欠くがBACH2の発現を有しmemoryB細胞としての性質を有する
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakataKatsuyoshi
en-aut-sei=Takata
en-aut-mei=Katsuyoshi
kn-aut-name=高田尚良
kn-aut-sei=高田
kn-aut-mei=尚良
aut-affil-num=1
ORCID=

en-aut-name=SatoYasuharu
en-aut-sei=Sato
en-aut-mei=Yasuharu
kn-aut-name=佐藤康晴
kn-aut-sei=佐藤
kn-aut-mei=康晴
aut-affil-num=2
ORCID=

en-aut-name=NakamuraNaoya
en-aut-sei=Nakamura
en-aut-mei=Naoya
kn-aut-name=中村直哉
kn-aut-sei=中村
kn-aut-mei=直哉
aut-affil-num=3
ORCID=

en-aut-name=TokunakaMami
en-aut-sei=Tokunaka
en-aut-mei=Mami
kn-aut-name=徳中摩美
kn-aut-sei=徳中
kn-aut-mei=摩美
aut-affil-num=4
ORCID=

en-aut-name=MikiYukari
en-aut-sei=Miki
en-aut-mei=Yukari
kn-aut-name=三木由香里
kn-aut-sei=三木
kn-aut-mei=由香里
aut-affil-num=5
ORCID=

en-aut-name=KikutiYara Yukie
en-aut-sei=Kikuti
en-aut-mei=Yara Yukie
kn-aut-name=菊池イアーラ幸江
kn-aut-sei=菊池
kn-aut-mei=イアーラ幸江
aut-affil-num=6
ORCID=

en-aut-name=IgarashiKazuhiko
en-aut-sei=Igarashi
en-aut-mei=Kazuhiko
kn-aut-name=五十嵐和彦
kn-aut-sei=五十嵐
kn-aut-mei=和彦
aut-affil-num=7
ORCID=

en-aut-name=ItoEtsuro
en-aut-sei=Ito
en-aut-mei=Etsuro
kn-aut-name=伊藤悦郎
kn-aut-sei=伊藤
kn-aut-mei=悦郎
aut-affil-num=8
ORCID=

en-aut-name=HarigaeHideo
en-aut-sei=Harigae
en-aut-mei=Hideo
kn-aut-name=張替秀雄
kn-aut-sei=張替
kn-aut-mei=秀雄
aut-affil-num=9
ORCID=

en-aut-name=KatoSeiichi
en-aut-sei=Kato
en-aut-mei=Seiichi
kn-aut-name=加藤省一
kn-aut-sei=加藤
kn-aut-mei=省一
aut-affil-num=10
ORCID=

en-aut-name=HayashiEiko
en-aut-sei=Hayashi
en-aut-mei=Eiko
kn-aut-name=林詠子
kn-aut-sei=林
kn-aut-mei=詠子
aut-affil-num=11
ORCID=

en-aut-name=OkaTakashi
en-aut-sei=Oka
en-aut-mei=Takashi
kn-aut-name=岡剛史
kn-aut-sei=岡
kn-aut-mei=剛史
aut-affil-num=12
ORCID=

en-aut-name=HoshiiYoshinobu
en-aut-sei=Hoshii
en-aut-mei=Yoshinobu
kn-aut-name=星井嘉信
kn-aut-sei=星井
kn-aut-mei=嘉信
aut-affil-num=13
ORCID=

en-aut-name=TariAkira
en-aut-sei=Tari
en-aut-mei=Akira
kn-aut-name=田利晶
kn-aut-sei=田利
kn-aut-mei=晶
aut-affil-num=14
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=岡田裕之
kn-aut-sei=岡田
kn-aut-mei=裕之
aut-affil-num=15
ORCID=

en-aut-name=MohamadoABD Alkader Lamia
en-aut-sei=Mohamado
en-aut-mei=ABD Alkader Lamia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=前田嘉信
kn-aut-sei=前田
kn-aut-mei=嘉信
aut-affil-num=17
ORCID=

en-aut-name=TanimotoMitsune
en-aut-sei=Tanimoto
en-aut-mei=Mitsune
kn-aut-name=谷本光音
kn-aut-sei=谷本
kn-aut-mei=光音
aut-affil-num=18
ORCID=

en-aut-name=KinoshitaTomohiro
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en-aut-mei=Tomohiro
kn-aut-name=木下朝博
kn-aut-sei=木下
kn-aut-mei=朝博
aut-affil-num=19
ORCID=

en-aut-name=YoshinoTadashi
en-aut-sei=Yoshino
en-aut-mei=Tadashi
kn-aut-name=吉野正
kn-aut-sei=吉野
kn-aut-mei=正
aut-affil-num=20
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理）

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科病理学（腫瘍病理）

affil-num=3
en-affil=
kn-affil=東海大学医学部　病理診断学講座

affil-num=4
en-affil=
kn-affil=東海大学医学部　病理診断学講座

affil-num=5
en-affil=
kn-affil=香川保健医療短期大学

affil-num=6
en-affil=
kn-affil=東海大学医学部　病理診断学講座

affil-num=7
en-affil=
kn-affil=東北大学大学院医学系研究科 生物化学分野

affil-num=8
en-affil=
kn-affil=弘前大学医学部　小児科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 血液・免疫病学分野

affil-num=10
en-affil=
kn-affil=名古屋大学病院　病理部

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理）

affil-num=12
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理）

affil-num=13
en-affil=
kn-affil=山口大学医学部　病理学

affil-num=14
en-affil=
kn-affil=広島赤十字・原爆病院　消化器内科

affil-num=15
en-affil=
kn-affil=岡山大学病院　光学診療部

affil-num=16
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理）

affil-num=17
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科血液・腫瘍・呼吸器内科学

affil-num=18
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科血液・腫瘍・呼吸器内科学

affil-num=19
en-affil=
kn-affil=愛知がんセンター　血液細胞療法部

affil-num=20
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理）
en-keyword=follicular lymphoma
kn-keyword=follicular lymphoma
en-keyword=gastrointestinal tract
kn-keyword=gastrointestinal tract
en-keyword=BACH2
kn-keyword=BACH2
en-keyword=memory B cell
kn-keyword=memory B cell
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=非小細胞肺癌に対する導入化学放射線療法における予後因子としての癌幹細胞関連マーカー
kn-title=Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SienKazuhiko
en-aut-sei=Sien
en-aut-mei=Kazuhiko
kn-aut-name=枝園和彦
kn-aut-sei=枝園
kn-aut-mei=和彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=転移性尿路上皮癌に対する全身抗癌化学療法後の救済手術は生存期間に強い影響を与える
kn-title=Could salvage surgery after chemotherapy have clinical impact on cancer survival of patients with metastatic urothelial carcinoma?
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=BekkuKensuke
en-aut-sei=Bekku
en-aut-mei=Kensuke
kn-aut-name=別宮謙介
kn-aut-sei=別宮
kn-aut-mei=謙介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=CD133やCD87を発現している肺小細胞癌の細胞亜集団は化学療法に対して抵抗性を示す
kn-title=Subpopulation of small-cell lung cancer cells expressing CD133 and CD87 show resistance to chemotherapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KuboToshio
en-aut-sei=Kubo
en-aut-mei=Toshio
kn-aut-name=久保寿夫
kn-aut-sei=久保
kn-aut-mei=寿夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=CA19-9とSPan-1のモニタリングにより膵がん化学療法中の早期増悪判定が可能である
kn-title=Monitoring of CA19-9 and SPan-1 can facilitate the earlier confirmation of progressing pancreatic cancer during chemotherapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TsumiKouichirou
en-aut-sei=Tsumi
en-aut-mei=Kouichirou
kn-aut-name=堤康一郎
kn-aut-sei=堤
kn-aut-mei=康一郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=2
article-no=
start-page=63
end-page=112
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=195810
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=東南アジア諸国の河川の化学的研究　タイ国の水質について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小林純
kn-aut-sei=小林
kn-aut-mei=純
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=40
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1955
dt-pub=19550125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=本邦河川の化学的硏究（第3報）　関東地方の水質について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小林純
kn-aut-sei=小林
kn-aut-mei=純
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=18
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19540331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=本邦河川の化学的研究　第3報　九州地方の水質について　後篇
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小林純
kn-aut-sei=小林
kn-aut-mei=純
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=37
cd-vols=
no-issue=4
article-no=
start-page=30
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1948
dt-pub=19480910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=灌漑水の化学（2）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小林純
kn-aut-sei=小林
kn-aut-mei=純
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20121231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=B細胞非ホジキンリンパ腫の免疫グロブリン軽鎖制限に対する細胞診による免疫細胞化学二重染色法の有用性
kn-title=Usefulness of immunoglobulin light-chain restriction on immunocytochemical double staining for the cytological diagnosis of B-cell non-Hodgkin's lymphoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ShimouraYasumasa
en-aut-sei=Shimoura
en-aut-mei=Yasumasa
kn-aut-name=下浦泰昌
kn-aut-sei=下浦
kn-aut-mei=泰昌
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=67
end-page=68
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Guideline for the prevention of postoperative infections
kn-title=術後感染予防のための抗菌薬使用ガイドライン
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ShinouraSusumu
en-aut-sei=Shinoura
en-aut-mei=Susumu
kn-aut-name=篠浦先
kn-aut-sei=篠浦
kn-aut-mei=先
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院　臓器移植医療センター

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=51
end-page=55
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A successful rechallenge with cetuximab for a case with metastatic rectal cancer
kn-title=一次治療でセツキシマブ不耐となった後，三次治療での再使用により奏功した進行大腸癌の一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　A 55-year-old man who had been diagnosed with rectal cancer with multiple liver metastases and lymph node metastases on colonoscopy and computed tomography (CT) was referred to Okayama University Hospital for treatment. Based on the diagnosis of non-curative rectal cancer, we planned to perform systematic chemotherapy after surgical resection. We performed a low anterior resection of a 36×35 mm upper rectal moderately differentiated adenocarcinoma with wil-type KRAS. After the resection, a FOLFIRI regimen with cetuximab was given as the first-line chemotherapy. Although metastatic lesions in the liver showed shrinkage, we decided to switch regimens because of intolerable adverse events. A modified FOLFOX6 regimen with bevacizumab was administered as the second-line treatment. There were no signs of disease progression until eight months later, when positron emission tomography (PET)/CT scans revealed that the new metastatic lesions appeared. As the third-line treatment, an irinotecan with cetuximab regimen was administered, leading to a good response for over 12 months.
　We experienced a successful rechallenge with cetuximab for a case with metastatic rectal cancer. For patients with wild-type KRAS colorectal cancer, rechallenge with cetuximab-based chemotherapy can be an effective therapeutic option.
en-copyright=
kn-copyright=

en-aut-name=InadaRyo
en-aut-sei=Inada
en-aut-mei=Ryo
kn-aut-name=稲田涼
kn-aut-sei=稲田
kn-aut-mei=涼
aut-affil-num=1
ORCID=

en-aut-name=NagasakaTakeshi
en-aut-sei=Nagasaka
en-aut-mei=Takeshi
kn-aut-name=永坂岳司
kn-aut-sei=永坂
kn-aut-mei=岳司
aut-affil-num=2
ORCID=

en-aut-name=MoriYoshiko
en-aut-sei=Mori
en-aut-mei=Yoshiko
kn-aut-name=母里淑子
kn-aut-sei=母里
kn-aut-mei=淑子
aut-affil-num=3
ORCID=

en-aut-name=UmedaYuzo
en-aut-sei=Umeda
en-aut-mei=Yuzo
kn-aut-name=楳田祐三
kn-aut-sei=楳田
kn-aut-mei=祐三
aut-affil-num=4
ORCID=

en-aut-name=KubotaNobuhito
en-aut-sei=Kubota
en-aut-mei=Nobuhito
kn-aut-name=久保田暢人
kn-aut-sei=久保田
kn-aut-mei=暢人
aut-affil-num=5
ORCID=

en-aut-name=MorikawaTatsuya
en-aut-sei=Morikawa
en-aut-mei=Tatsuya
kn-aut-name=森川達也
kn-aut-sei=森川
kn-aut-mei=達也
aut-affil-num=6
ORCID=

en-aut-name=KondoYoshitaka
en-aut-sei=Kondo
en-aut-mei=Yoshitaka
kn-aut-name=近藤喜太
kn-aut-sei=近藤
kn-aut-mei=喜太
aut-affil-num=7
ORCID=

en-aut-name=UnoFutoshi
en-aut-sei=Uno
en-aut-mei=Futoshi
kn-aut-name=宇野太
kn-aut-sei=宇野
kn-aut-mei=太
aut-affil-num=8
ORCID=

en-aut-name=SadamoriYu
en-aut-sei=Sadamori
en-aut-mei=Yu
kn-aut-name=貞森裕
kn-aut-sei=貞森
kn-aut-mei=裕
aut-affil-num=9
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=10
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
en-keyword=大腸癌（colorectal cancer）
kn-keyword=大腸癌（colorectal cancer）
en-keyword=化学療法（chemotherapy）
kn-keyword=化学療法（chemotherapy）
en-keyword=セツキシマブ再投与（cetuximab rechallenge）
kn-keyword=セツキシマブ再投与（cetuximab rechallenge）
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=47
end-page=50
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of metastatic cecal cancer with mutation in the BRAF oncogene and poor survival
kn-title=予後不良な経過をたどったBRAF遺伝子変異を伴うStage Ⅳ大腸癌の１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　A 79-year-old woman visited a previous hospital with a complaint of general fatigue. The patient was diagnosed with cecal cancer with multiple liver metastases and lymph node metastases on colonoscopy, abdominal ultrasonography and CT scan, and was referred to our division for treatment. Based on the diagnosis of non-curative colonic cancer, we planned to perform systematic chemotherapy after local surgical treatment. We performed an ileocecal resection, and the specimen showed poorly differentiated adenocarcinoma with mutation in the BRAF oncogene. After the surgical treatment, the tumor grew rapidly and the patient died from cancer on the 19th postoperative day without having the opportunity to undergo chemotherapy.
　Multiple genetic and epigenetic alterations in oncogenes and tumor suppressor genes are involved in the process of colorectal carcinogenesis. Some of the alterations have been identified as predictive and prognostic biomarkers. A mutation in the BRAF oncogene was reported to be associated with a very unfavorable prognosis in colorectal cancers. Some of the cases with rapid progression are suggested to have the BRAF oncogene mutation. According to our experience, chemotherapy before surgical treatment might improve the prognosis of cases with the BRAF mutation.
en-copyright=
kn-copyright=

en-aut-name=InadaRyo
en-aut-sei=Inada
en-aut-mei=Ryo
kn-aut-name=稲田涼
kn-aut-sei=稲田
kn-aut-mei=涼
aut-affil-num=1
ORCID=

en-aut-name=NagasakaTakeshi
en-aut-sei=Nagasaka
en-aut-mei=Takeshi
kn-aut-name=永坂岳司
kn-aut-sei=永坂
kn-aut-mei=岳司
aut-affil-num=2
ORCID=

en-aut-name=TakeharaKiyoto
en-aut-sei=Takehara
en-aut-mei=Kiyoto
kn-aut-name=竹原清人
kn-aut-sei=竹原
kn-aut-mei=清人
aut-affil-num=3
ORCID=

en-aut-name=SugiharaMasahiro
en-aut-sei=Sugihara
en-aut-mei=Masahiro
kn-aut-name=杉原正大
kn-aut-sei=杉原
kn-aut-mei=正大
aut-affil-num=4
ORCID=

en-aut-name=MoriYoshiko
en-aut-sei=Mori
en-aut-mei=Yoshiko
kn-aut-name=母里淑子
kn-aut-sei=母里
kn-aut-mei=淑子
aut-affil-num=5
ORCID=

en-aut-name=UmedaYuzo
en-aut-sei=Umeda
en-aut-mei=Yuzo
kn-aut-name=楳田祐三
kn-aut-sei=楳田
kn-aut-mei=祐三
aut-affil-num=6
ORCID=

en-aut-name=KubotaNobuhito
en-aut-sei=Kubota
en-aut-mei=Nobuhito
kn-aut-name=久保田暢人
kn-aut-sei=久保田
kn-aut-mei=暢人
aut-affil-num=7
ORCID=

en-aut-name=MorikawaTatsuya
en-aut-sei=Morikawa
en-aut-mei=Tatsuya
kn-aut-name=森川達也
kn-aut-sei=森川
kn-aut-mei=達也
aut-affil-num=8
ORCID=

en-aut-name=KondoYoshitaka
en-aut-sei=Kondo
en-aut-mei=Yoshitaka
kn-aut-name=近藤喜太
kn-aut-sei=近藤
kn-aut-mei=喜太
aut-affil-num=9
ORCID=

en-aut-name=UnoFutoshi
en-aut-sei=Uno
en-aut-mei=Futoshi
kn-aut-name=宇野太
kn-aut-sei=宇野
kn-aut-mei=太
aut-affil-num=10
ORCID=

en-aut-name=SadamoriYu
en-aut-sei=Sadamori
en-aut-mei=Yu
kn-aut-name=貞森裕
kn-aut-sei=貞森
kn-aut-mei=裕
aut-affil-num=11
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=12
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=13
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=12
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=13
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
en-keyword=大腸癌（colorectal cancer）
kn-keyword=大腸癌（colorectal cancer）
en-keyword=BRAF変異（BRAF mutation）
kn-keyword=BRAF変異（BRAF mutation）
en-keyword=化学療法（chemotherapy）
kn-keyword=化学療法（chemotherapy）
en-keyword=分子標的薬（molecular target therapy）
kn-keyword=分子標的薬（molecular target therapy）
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=35
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An epidemiologically rare case of Vibrio vulnificus infection that occurred in October in an inland city of Japan
kn-title=内陸地津山で発症した季節外れのVibrio vulnificus感染症
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　A 68-year-old man with alcohol addiction, who lived in the suburbs of Tsuyama, an inland city located in northeast Okayama prefecture, was transported to the emergency unit of the Tsuyama Central Hospital in a state of cardiopulmonary arrest (CPA). Despite rigorous systemic investigation and treatment, the patient died 2 hours after arrival. After his death, Vibrio vulnificus was isolated from his blood culture.
　Vibrio vulnificus causes fatal infection in humans, usually only in areas located close to the sea where appropriate temperature and suitable salt concentration for its growth are available. Therefore, its occurrence is epidemiologically restricted ; in Japan, the western coastal areas, especially in summers, are reported to be the high-risk regions. This is a rare case because it occurred in a city approximately 50 kilometers from both the Sea of Japan and the Pacific coast of Okayama, and at the end of October in 2011. Economic development and distribution systems have made it possible to transport various food products from coastal areas or abroad to any place in a short time, such that these infections can potentially develop in areas other than expected. We should be aware of the increasing risk of Vibrio vulnificus infection during any season and at any place, especially in patients with abnormal liver function.
en-copyright=
kn-copyright=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=萩谷英大
kn-aut-sei=萩谷
kn-aut-mei=英大
aut-affil-num=1
ORCID=

en-aut-name=ShiotaSumiko
en-aut-sei=Shiota
en-aut-mei=Sumiko
kn-aut-name=塩田澄子
kn-aut-sei=塩田
kn-aut-mei=澄子
aut-affil-num=2
ORCID=

en-aut-name=MiyoshiShin-ichi
en-aut-sei=Miyoshi
en-aut-mei=Shin-ichi
kn-aut-name=三好伸一
kn-aut-sei=三好
kn-aut-mei=伸一
aut-affil-num=3
ORCID=

en-aut-name=KuroeYasutoshi
en-aut-sei=Kuroe
en-aut-mei=Yasutoshi
kn-aut-name=黒江泰利
kn-aut-sei=黒江
kn-aut-mei=泰利
aut-affil-num=4
ORCID=

en-aut-name=NojimaHiroyoshi
en-aut-sei=Nojima
en-aut-mei=Hiroyoshi
kn-aut-name=野島宏悦
kn-aut-sei=野島
kn-aut-mei=宏悦
aut-affil-num=5
ORCID=

en-aut-name=OtaniShinkichi
en-aut-sei=Otani
en-aut-mei=Shinkichi
kn-aut-name=大谷晋吉
kn-aut-sei=大谷
kn-aut-mei=晋吉
aut-affil-num=6
ORCID=

en-aut-name=SugiyamaJunichi
en-aut-sei=Sugiyama
en-aut-mei=Junichi
kn-aut-name=杉山淳一
kn-aut-sei=杉山
kn-aut-mei=淳一
aut-affil-num=7
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=内藤宏道
kn-aut-sei=内藤
kn-aut-mei=宏道
aut-affil-num=8
ORCID=

en-aut-name=KawanishiSusumu
en-aut-sei=Kawanishi
en-aut-mei=Susumu
kn-aut-name=川西進
kn-aut-sei=川西
kn-aut-mei=進
aut-affil-num=9
ORCID=

en-aut-name=HagiokaShingo
en-aut-sei=Hagioka
en-aut-mei=Shingo
kn-aut-name=萩岡信吾
kn-aut-sei=萩岡
kn-aut-mei=信吾
aut-affil-num=10
ORCID=

en-aut-name=MorimotoNaoki
en-aut-sei=Morimoto
en-aut-mei=Naoki
kn-aut-name=森本直樹
kn-aut-sei=森本
kn-aut-mei=直樹
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=2
en-affil=
kn-affil=就実大学薬学部　病原微生物学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　衛生微生物化学

affil-num=4
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=5
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=6
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=7
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=8
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=9
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=10
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=11
en-affil=
kn-affil=津山中央病院　救命救急センター
en-keyword=Vibrio vulnificus
kn-keyword=Vibrio vulnificus
END

start-ver=1.4
cd-journal=joma
no-vol=152
cd-vols=
no-issue=
article-no=
start-page=65
end-page=74
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Changes in Physics Education for Learning Disabilities in Germany － Comparative Study between the Old and the New Textbook －
kn-title=ドイツにおける学習障害児のための物理教育の変遷 ― 新旧教科書の比較考察 ―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=ドイツにおける学習障害児のための新旧の学校種に焦点を当て，新旧教科書などに基づき，
物理教育の変遷を明らかにした。かつての学習障害児学校，今日の学習障害特別支援学校の
教科・分野の枠組みに対応して，25年程度の隔たりを有している旧教科書は，教科理化（物
理／化学）の第１分冊である物理教科書であり，新教科書は教科事象科の分冊の１つ，物理
分野を含むいわば科学（理科）教科書といえる。章立てなどから，気象，飛行がなくなった
こと，始まりが力でなく熱，終わりが電気でなく力に変わったこと，索引からは，７割程度
が消え，６割程度が更新されていること，しかし，物理内における６分野区分間の多少の順
は，新旧でほぼ同じであること，６分野以外は，無視できない割合を占め，技術関係が新旧
ともに大きな位置を占めていること，さらに，事例などからも，変化の一端を，明らかにした。
en-copyright=
kn-copyright=

en-aut-name=TanakaKenji
en-aut-sei=Tanaka
en-aut-mei=Kenji
kn-aut-name=田中賢二
kn-aut-sei=田中
kn-aut-mei=賢二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科自然教育学系理科教育講座
en-keyword=ドイツ
kn-keyword=ドイツ
en-keyword=学習障害児
kn-keyword=学習障害児
en-keyword=物理教育
kn-keyword=物理教育
en-keyword=教科書
kn-keyword=教科書
en-keyword=歴史的研究
kn-keyword=歴史的研究
END

start-ver=1.4
cd-journal=joma
no-vol=34
cd-vols=
no-issue=
article-no=
start-page=58
end-page=66
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=平成23年度業務報告
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境管理センター
kn-aut-sei=岡山大学環境管理センター
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=151
cd-vols=
no-issue=
article-no=
start-page=69
end-page=80
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20121127
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Research on the Physics Education of the Special School for Learning Disabilities of Germany by Analysis of a Science Textbook
kn-title=ドイツの学習障害特別支援学校における物理教育 ― 現行（科学）教科書の分析 ―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=ドイツの学習障害特別支援学校に焦点を当て，学習指導要領，検定済教科書などに基づき，
物理教育の現状分析を行った。初等教育段階においては，教科・分野・領域などの枠を持っ
た物理教育などが設定されておらず，前期中等教育段階においては，ほとんどの学校種で教
科，物理があるのとは違って，学習障害特別支援学校では，教科事象科のもとに分野物理が
位置づけられている。物理，化学，生物の合本のようになっている教科書において，物理分
野の節数や頁数は，生物分野より少なく，化学分野より多かった。索引数の違いは，電気＞
その他＞光＞力・機械・運動＞音＞熱＞磁気；無機化学＞有機化学＞物理化学＞その他；人
体＞動物＞植物＞その他＞一般生物；であり，生物・化学分野に比して物理分野においてそ
の他が大きな位置を占めているという特徴を見いだした。
en-copyright=
kn-copyright=

en-aut-name=TanakaKenji
en-aut-sei=Tanaka
en-aut-mei=Kenji
kn-aut-name=田中賢二
kn-aut-sei=田中
kn-aut-mei=賢二
aut-affil-num=1
ORCID=

en-aut-name=TanakaKeita
en-aut-sei=Tanaka
en-aut-mei=Keita
kn-aut-name=田中啓太
kn-aut-sei=田中
kn-aut-mei=啓太
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科自然教育学系理科教育講座

affil-num=2
en-affil=
kn-affil=津市立久居西中学校
en-keyword=ドイツ
kn-keyword=ドイツ
en-keyword=学習障害特別支援学校
kn-keyword=学習障害特別支援学校
en-keyword=物理教育
kn-keyword=物理教育
en-keyword=教科書
kn-keyword=教科書
en-keyword=現状分析
kn-keyword=現状分析
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=3
article-no=
start-page=243
end-page=247
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20121203
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of intracystic carcinoma of the breast showing pathological complete response by neoadjuvant chemotherapy
kn-title=術前化学療法により壁が菲薄化し組織学的寛解（pCR）となった巨大嚢胞内乳癌の１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　A 31-year-old woman presented to our hospital because of a lump 5cm in diameter in her right breast. Ultrasonography revealed a multilocular cystic mass with partial thickening of the wall and the septum. Core needle biopsy (CNB) of the septum confirmed invasive ductal carcinoma. The patient was administered neoadjuvant chemotherapy consisting of 12 cycles of weekly paclitaxel followed by 4 cycles of FEC (5FU, Epilubicin and cyclophosphamide). While the thickness of the wall and septum became thinner, the tumor size did not change in diameter. She underwent right mastectomy and sentinel node biopsy. Post-surgical histopathological findings showed a pathological complete response (pCR).<br>
　We report a rare case of invasive ductal carcinoma presenting a multilobular phenotype which showed pCR by neoadjuvant chemotherapy despite no size reduction of the tumor.
en-copyright=
kn-copyright=

en-aut-name=ImadaTakako
en-aut-sei=Imada
en-aut-mei=Takako
kn-aut-name=今田孝子
kn-aut-sei=今田
kn-aut-mei=孝子
aut-affil-num=1
ORCID=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=松岡順治
kn-aut-sei=松岡
kn-aut-mei=順治
aut-affil-num=2
ORCID=

en-aut-name=MotokiTakayuki
en-aut-sei=Motoki
en-aut-mei=Takayuki
kn-aut-name=元木崇之
kn-aut-sei=元木
kn-aut-mei=崇之
aut-affil-num=3
ORCID=

en-aut-name=IwamotoTakayuki
en-aut-sei=Iwamoto
en-aut-mei=Takayuki
kn-aut-name=岩本高行
kn-aut-sei=岩本
kn-aut-mei=高行
aut-affil-num=4
ORCID=

en-aut-name=OomoriMasako
en-aut-sei=Oomori
en-aut-mei=Masako
kn-aut-name=大森昌子
kn-aut-sei=大森
kn-aut-mei=昌子
aut-affil-num=5
ORCID=

en-aut-name=IhaSigemichi
en-aut-sei=Iha
en-aut-mei=Sigemichi
kn-aut-name=伊波茂道
kn-aut-sei=伊波
kn-aut-mei=茂道
aut-affil-num=6
ORCID=

en-aut-name=HongoToshie
en-aut-sei=Hongo
en-aut-mei=Toshie
kn-aut-name=本後登志江
kn-aut-sei=本後
kn-aut-mei=登志江
aut-affil-num=7
ORCID=

en-aut-name=HenmiNoriko
en-aut-sei=Henmi
en-aut-mei=Noriko
kn-aut-name=逸見典子
kn-aut-sei=逸見
kn-aut-mei=典子
aut-affil-num=8
ORCID=

en-aut-name=MakabeMikio
en-aut-sei=Makabe
en-aut-mei=Mikio
kn-aut-name=真壁幹夫
kn-aut-sei=真壁
kn-aut-mei=幹夫
aut-affil-num=9
ORCID=

en-aut-name=NogamiHiromi
en-aut-sei=Nogami
en-aut-mei=Hiromi
kn-aut-name=野上浩實
kn-aut-sei=野上
kn-aut-mei=浩實
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=5
en-affil=
kn-affil=岡山大学病院　病理診断科

affil-num=6
en-affil=
kn-affil=岡山大福クリニック

affil-num=7
en-affil=
kn-affil=岡山大福クリニック

affil-num=8
en-affil=
kn-affil=岡山大福クリニック

affil-num=9
en-affil=
kn-affil=岡山中央病院

affil-num=10
en-affil=
kn-affil=野上病院
en-keyword=嚢胞内乳癌（intracystic breast cancer）
kn-keyword=嚢胞内乳癌（intracystic breast cancer）
en-keyword=術前化学療法（neoadjuvant chemotherapy）
kn-keyword=術前化学療法（neoadjuvant chemotherapy）
en-keyword=組織学的完全奏功（pahthological CR）
kn-keyword=組織学的完全奏功（pahthological CR）
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=3
article-no=
start-page=207
end-page=210
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20121203
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Liposomal delivery of microRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitor resistance in lung cancer cells
kn-title=EGFRチロシンキナーゼ阻害薬耐性肺癌細胞に対するmicroRNA-7発現プラスミドのリポソームを用いた導入による克服の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=RaiKammei
en-aut-sei=Rai
en-aut-mei=Kammei
kn-aut-name=頼冠名
kn-aut-sei=頼
kn-aut-mei=冠名
aut-affil-num=1
ORCID=

en-aut-name=TakigawaNagio
en-aut-sei=Takigawa
en-aut-mei=Nagio
kn-aut-name=瀧川奈義夫
kn-aut-sei=瀧川
kn-aut-mei=奈義夫
aut-affil-num=2
ORCID=

en-aut-name=ItoSachio
en-aut-sei=Ito
en-aut-mei=Sachio
kn-aut-name=伊藤佐智夫
kn-aut-sei=伊藤
kn-aut-mei=佐智夫
aut-affil-num=3
ORCID=

en-aut-name=KashiharaHiromi
en-aut-sei=Kashihara
en-aut-mei=Hiromi
kn-aut-name=柏原宏美
kn-aut-sei=柏原
kn-aut-mei=宏美
aut-affil-num=4
ORCID=

en-aut-name=IchiharaEiki
en-aut-sei=Ichihara
en-aut-mei=Eiki
kn-aut-name=市原英基
kn-aut-sei=市原
kn-aut-mei=英基
aut-affil-num=5
ORCID=

en-aut-name=YasudaTatsuji
en-aut-sei=Yasuda
en-aut-mei=Tatsuji
kn-aut-name=保田立二
kn-aut-sei=保田
kn-aut-mei=立二
aut-affil-num=6
ORCID=

en-aut-name=ShimizuKenji
en-aut-sei=Shimizu
en-aut-mei=Kenji
kn-aut-name=清水憲二
kn-aut-sei=清水
kn-aut-mei=憲二
aut-affil-num=7
ORCID=

en-aut-name=TanimotoMitsune
en-aut-sei=Tanimoto
en-aut-mei=Mitsune
kn-aut-name=谷本光音
kn-aut-sei=谷本
kn-aut-mei=光音
aut-affil-num=8
ORCID=

en-aut-name=KiuraKatsuyuki
en-aut-sei=Kiura
en-aut-mei=Katsuyuki
kn-aut-name=木浦勝行
kn-aut-sei=木浦
kn-aut-mei=勝行
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　分子遺伝学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞化学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　分子遺伝学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学
en-keyword=microRNA7
kn-keyword=microRNA7
en-keyword=EGFR
kn-keyword=EGFR
en-keyword=oncogene addiction
kn-keyword=oncogene addiction
en-keyword=lung cancer
kn-keyword=lung cancer
en-keyword=liposome
kn-keyword=liposome
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=3
article-no=
start-page=477
end-page=494
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Die Abänderung vom § 21 Abs．1 des Gesetzes gegen den unlauteren Wettbewerb im Jahr 2009
kn-title=営業秘密侵害罪に係る不正競争防止法の平成二一年改正について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IchiharaA.
en-aut-sei=Ichihara
en-aut-mei=A.
kn-aut-name=一原亜貴子
kn-aut-sei=一原
kn-aut-mei=亜貴子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=3
article-no=
start-page=433
end-page=475
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=L’assistance publique en France pendant la Révolution sous la Convention（1）
kn-title=フランス革命期の公的扶助制度の形成―国民公会期を中心に（一）―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HatanoS.
en-aut-sei=Hatano
en-aut-mei=S.
kn-aut-name=波多野敏
kn-aut-sei=波多野
kn-aut-mei=敏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=2
article-no=
start-page=165
end-page=166
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Guidelines for the treatment of urinary tract infections
kn-title=尿路感染症治療ガイドライン
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=UeharaShinya
en-aut-sei=Uehara
en-aut-mei=Shinya
kn-aut-name=上原慎也
kn-aut-sei=上原
kn-aut-mei=慎也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=2
article-no=
start-page=129
end-page=136
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Antibacterial efficacy of photocatalytic reaction on titanium dioxide-coated ceramic air filters
kn-title=酸化チタン担持セラミックフィルターの光触媒反応による抗菌効果の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Titanium dioxide (TiO<sub>2</sub>) photocatalysis generates reactive oxygen species such as ・OH and ・O<sub>2</sub>-, which can effectively eliminate organic compounds. In the present study, we evaluated the antibacterial and antifungal effects of TiO<sub>2</sub>-coated ceramic air filters in both laboratory and hospital settings. Photocatalysis with the TiO<sub>2</sub>-coated ceramic filter effectively inactivated all 4 pathogenic organisms tested. Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. After the photocatalysis reaction for 4 h under UV-A (365nm, 250μW/㎠) irradiation, the percentage reductions of the number of E. coli, P. aeruginosa, S. aureus, C. albicans cells were 99.9%, 98.9%, 97.7% and 99.9%, respectively, indicating that Gram-negative bacteria are more susceptible to such photocatalysis than Gram-positive bacteria. Scanning electron microscopic analysis showed damage to the cytoplasmic membrane and cell wall by photocatalysis : consistent with above observations, the morphological change of Gram-negative E. coli was greater than that of Gram-positive S. aureus. 　Further, an air cleaner equipped with a TiO<sub>2</sub>-coated ceramic filter significantly decreased the number of bacteria floating in hospitals. 　These results indicate that air cleaners with TiO<sub>2</sub>-coated ceramic filters could be useful in reducing the incidence of nosocomial infections.
en-copyright=
kn-copyright=

en-aut-name=NakaoMiyuki
en-aut-sei=Nakao
en-aut-mei=Miyuki
kn-aut-name=中尾美幸
kn-aut-sei=中尾
kn-aut-mei=美幸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　病原細菌学
en-keyword=光触媒（photocatalysis）
kn-keyword=光触媒（photocatalysis）
en-keyword=酸化チタン担持セラミックフィルター（TiO<sub>2</sub>-coated ceramic air filters）
kn-keyword=酸化チタン担持セラミックフィルター（TiO<sub>2</sub>-coated ceramic air filters）
en-keyword=抗菌効果（antimicrobial effect）
kn-keyword=抗菌効果（antimicrobial effect）
en-keyword=院内感染（nosocomial infection）
kn-keyword=院内感染（nosocomial infection）
en-keyword=空気清浄機（air cleaner）
kn-keyword=空気清浄機（air cleaner）
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=3
article-no=
start-page=183
end-page=190
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Dynamin 2 in Charcot-Marie-Tooth Disease
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Charcot-Marie-Tooth disease (CMT) is an inherited neuronal disorder, and is induced by mutations of various genes associated with intracellular membrane traffic and cytoskeleton. A large GTPase, dynamin, which is known as a fission protein for endocytic vesicles, was identified as a gene responsible
for dominant-intermediate CMT type 2B (DI-CMT2B). Of these mutants, the PH domain, which is required for interaction with phosphoinositides, was mutated in several families. Interestingly, the expression of a deletion mutant, 551Δ3, did not impair endocytosis, but induced abnormal accumulation
of microtubules. Recent evidence has shown that dynamin 2 regulates the dynamic instability of microtubules, and 551Δ3 lacks this function. We propose a model for the regulation of the dynamic instability of microtubules by dynamin 2 and discuss the relationship between dynamin 2 and CMT.
en-copyright=
kn-copyright=

en-aut-name=TanabeKenji
en-aut-sei=Tanabe
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakeiKohji
en-aut-sei=Takei
en-aut-mei=Kohji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Neuroscience, Okayama University Graduate School of Medicine

affil-num=2
en-affil=
kn-affil=Department of Neuroscience, Okayama University Graduate School of Medicine
en-keyword=neuropathy
kn-keyword=neuropathy
en-keyword=Charcot-Marie-Tooth disease
kn-keyword=Charcot-Marie-Tooth disease
en-keyword=membrane traffic
kn-keyword=membrane traffic
en-keyword=dynamin
kn-keyword=dynamin
en-keyword=microtubules
kn-keyword=microtubules
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Paclitaxelの新規微粒子製剤化と血管新生阻害剤との併用によるがん化学療法の最適化を目指した基礎的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YoshizawaYuta
en-aut-sei=Yoshizawa
en-aut-mei=Yuta
kn-aut-name=吉澤雄太
kn-aut-sei=吉澤
kn-aut-mei=雄太
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=チョウジSyzygium aromaticumのタンニンおよび関連化合物の化学構造およびそれらの多剤耐性黄色ブドウ球菌に対する効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HouReimei
en-aut-sei=Hou
en-aut-mei=Reimei
kn-aut-name=包黎明
kn-aut-sei=包
kn-aut-mei=黎明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=化学物質の光毒性・光遺伝毒性試験における培養ヒトケラチノサイトの有用性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HorinouchiMayumi
en-aut-sei=Horinouchi
en-aut-mei=Mayumi
kn-aut-name=堀ノ内眞弓
kn-aut-sei=堀ノ内
kn-aut-mei=眞弓
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Aktの活性化は、小児のB前駆細胞性急性リンパ性白血病における予後不良と化学療法抵抗性に関連している
kn-title=Activation of Akt is Associated With Poor Prognosis and Chemotherapeutic Resistance in Pediatric B-Precursor Acute Lymphoblastic Leukemia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MorishitaNaoto
en-aut-sei=Morishita
en-aut-mei=Naoto
kn-aut-name=森下直人
kn-aut-sei=森下
kn-aut-mei=直人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=
article-no=
start-page=59
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Usefulness of ICR mice as genetic resources
kn-title=ICRマウスの遺伝子資源としての有用性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=ICR(Yok:ICR)mice were introduced into the National Instltute of Infectious Diseases in 1965,and have been bred and produced there.Two inbred mutant mouse strains,MPS and ICGN,were created using(originated from)Yok:ICR mice in 1986.The MPS and ICGN mouse strains have served as the
animal disease models of mycoplasma infectious disease and congenital nephritic syndrome,respectively.
Genetic variations were detected by the genetic monitoring of Yok:ICR mice using biochemical markers.However, no difference was detected in gene expression profiles between the MPS and ICGN mouse strains.ICR mice may harbor genes that are spontaneously mutated,thereby allowing the creation of
new pathological models through the segregation and/or selection(screening)of mutant genes.
en-copyright=
kn-copyright=

en-aut-name=YamamotoYoshie
en-aut-sei=Yamamoto
en-aut-mei=Yoshie
kn-aut-name=山本美江
kn-aut-sei=山本
kn-aut-mei=美江
aut-affil-num=1
ORCID=

en-aut-name=Uchio-YamadaKozue
en-aut-sei=Uchio-Yamada
en-aut-mei=Kozue
kn-aut-name=内尾-山田こずえ
kn-aut-sei=内尾-山田
kn-aut-mei=こずえ
aut-affil-num=2
ORCID=

en-aut-name=TakanoKaoru
en-aut-sei=Takano
en-aut-mei=Kaoru
kn-aut-name=高野薫
kn-aut-sei=高野
kn-aut-mei=薫
aut-affil-num=3
ORCID=

en-aut-name=OguraAtsuo
en-aut-sei=Ogura
en-aut-mei=Atsuo
kn-aut-name=小倉淳郎
kn-aut-sei=小倉
kn-aut-mei=淳郎
aut-affil-num=4
ORCID=

en-aut-name=AsanoToshihiko
en-aut-sei=Asano
en-aut-mei=Toshihiko
kn-aut-name=浅野敏彦
kn-aut-sei=浅野
kn-aut-mei=敏彦
aut-affil-num=5
ORCID=

en-aut-name=NakagawaMasarou
en-aut-sei=Nakagawa
en-aut-mei=Masarou
kn-aut-name=中川雅郎
kn-aut-sei=中川
kn-aut-mei=雅郎
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=国立感染症研究所

affil-num=2
en-affil=
kn-affil=医薬基盤研究所

affil-num=3
en-affil=
kn-affil=医薬基盤研究所

affil-num=4
en-affil=
kn-affil=理化学研究所

affil-num=5
en-affil=
kn-affil=国立感染症研究所

affil-num=6
en-affil=
kn-affil=国立感染症研究所
END

start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=
article-no=
start-page=58
end-page=66
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=平成22年度業務報告
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境管理センター
kn-aut-sei=岡山大学環境管理センター
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=2
article-no=
start-page=50
end-page=55
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201102
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=問われる産と学の決断と勇気
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OshikiToshiyuki
en-aut-sei=Oshiki
en-aut-mei=Toshiyuki
kn-aut-name=押木俊之
kn-aut-sei=押木
kn-aut-mei=俊之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=1
article-no=
start-page=63
end-page=66
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Pathological complete response of advanced gastric cancer with pyloric stenosis to neoadjuvant S-1/CDDP chemotherapy: A case report
kn-title=S-1/CDDP術前化学療法により組織学的CRが得られた幽門狭窄合併進行胃癌の１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 59-year-old man with epigastric discomfort and anorexia was referred to our hospital. Endoscopy revealed a type 3 advanced gastric cancer with pyloric stenosis diagnosed as a poorly differentiated adenocarcinoma in the biopsy specimens. A gastrojejunal bypass operation was performed because of direct invasion to the pancreas. The patient was treated by three courses of neoadjuvant chemotherapy with S-1/CDDP. Follow-up abdominal CT scan revealed that the primary tumor had become smaller, suggesting that a partial response had been achieved. Distal gastrectomy with D2 lymphadenectomy was performed. The histopathological examination showed no residual cancer cells in the primary lesion or dissected lymph nodes. Final chemotherapy efficacy was evaluated as Grade 3. The patient was treated with S-1 for one year after the gastrectomy and lymphadenectomy and has been followed up for 18 months without evidence of recurrence.
en-copyright=
kn-copyright=

en-aut-name=NishizakiMasahiko
en-aut-sei=Nishizaki
en-aut-mei=Masahiko
kn-aut-name=西崎正彦
kn-aut-sei=西崎
kn-aut-mei=正彦
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraYasuhiro
en-aut-sei=Fujiwara
en-aut-mei=Yasuhiro
kn-aut-name=藤原康宏
kn-aut-sei=藤原
kn-aut-mei=康宏
aut-affil-num=2
ORCID=

en-aut-name=ChoudaYasuhiro
en-aut-sei=Chouda
en-aut-mei=Yasuhiro
kn-aut-name=丁田泰宏
kn-aut-sei=丁田
kn-aut-mei=泰宏
aut-affil-num=3
ORCID=

en-aut-name=KanazawaTakashi
en-aut-sei=Kanazawa
en-aut-mei=Takashi
kn-aut-name=金澤卓
kn-aut-sei=金澤
kn-aut-mei=卓
aut-affil-num=4
ORCID=

en-aut-name=NinomiyaMotoki
en-aut-sei=Ninomiya
en-aut-mei=Motoki
kn-aut-name=二宮基樹
kn-aut-sei=二宮
kn-aut-mei=基樹
aut-affil-num=5
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=2
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=3
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=4
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=5
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
en-keyword=幽門狭窄 (pyloric stenosis)
kn-keyword=幽門狭窄 (pyloric stenosis)
en-keyword=進行胃癌 (advanced gastric cancer)
kn-keyword=進行胃癌 (advanced gastric cancer)
en-keyword=S-1/CDDP
kn-keyword=S-1/CDDP
en-keyword=術前化学療法 (neoadjuvant chemotherapy)
kn-keyword=術前化学療法 (neoadjuvant chemotherapy)
en-keyword=組織学的CR (pathological CR)
kn-keyword=組織学的CR (pathological CR)
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=1
article-no=
start-page=47
end-page=51
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical study of the prognostic factors in colorectal cancer patients with synchronous liver metastasis
kn-title=当院における大腸癌同時性肝転移症例の臨床病理学的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study was aimed to clarify the prognostic factors in colorectal cancer patients with synchronous liver metastasis. Fifty-four patients were assessed to evaluate prognoses according to various clinico-pathological factors and therapeutic procedures. The patients' survival was significantly related to extrahepatic distant metastasis and therapeutic procedures. Regarding therapeutic procedures, the liver resection group showed significantly improved survival compared with the chemotherapy group, especially in liver metastasis Grade B. For colorectal liver metastases, it is clear that liver resection is the most effective treatment at present. Further improvement of patient prognoses is expected to be achieved by future research on combination chemotherapy.
en-copyright=
kn-copyright=

en-aut-name=MiyasouHideaki
en-aut-sei=Miyasou
en-aut-mei=Hideaki
kn-aut-name=宮宗秀明
kn-aut-sei=宮宗
kn-aut-mei=秀明
aut-affil-num=1
ORCID=

en-aut-name=IwakawaKazuhide
en-aut-sei=Iwakawa
en-aut-mei=Kazuhide
kn-aut-name=岩川和秀
kn-aut-sei=岩川
kn-aut-mei=和秀
aut-affil-num=2
ORCID=

en-aut-name=InagakiMasaru
en-aut-sei=Inagaki
en-aut-mei=Masaru
kn-aut-name=稲垣優
kn-aut-sei=稲垣
kn-aut-mei=優
aut-affil-num=3
ORCID=

en-aut-name=KimuraYuuji
en-aut-sei=Kimura
en-aut-mei=Yuuji
kn-aut-name=木村祐司
kn-aut-sei=木村
kn-aut-mei=祐司
aut-affil-num=4
ORCID=

en-aut-name=NishieManabu
en-aut-sei=Nishie
en-aut-mei=Manabu
kn-aut-name=西江学
kn-aut-sei=西江
kn-aut-mei=学
aut-affil-num=5
ORCID=

en-aut-name=HamanoRyousuke
en-aut-sei=Hamano
en-aut-mei=Ryousuke
kn-aut-name=濱野亮輔
kn-aut-sei=濱野
kn-aut-mei=亮輔
aut-affil-num=6
ORCID=

en-aut-name=TokunagaNaoyuki
en-aut-sei=Tokunaga
en-aut-mei=Naoyuki
kn-aut-name=徳永尚之
kn-aut-sei=徳永
kn-aut-mei=尚之
aut-affil-num=7
ORCID=

en-aut-name=TunemitsuYousuke
en-aut-sei=Tunemitsu
en-aut-mei=Yousuke
kn-aut-name=常光洋輔
kn-aut-sei=常光
kn-aut-mei=洋輔
aut-affil-num=8
ORCID=

en-aut-name=OtsukaShinya
en-aut-sei=Otsuka
en-aut-mei=Shinya
kn-aut-name=大塚眞哉
kn-aut-sei=大塚
kn-aut-mei=眞哉
aut-affil-num=9
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=2
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=3
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=4
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=5
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=6
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=7
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=8
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=9
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=10
en-affil=
kn-affil=国立病院機構福山医療センター　外科
en-keyword=大腸癌 (colorectal cancer)
kn-keyword=大腸癌 (colorectal cancer)
en-keyword=同時性肝転移 (synchronous liver metastasis)
kn-keyword=同時性肝転移 (synchronous liver metastasis)
en-keyword=肝切除 (liver resection)
kn-keyword=肝切除 (liver resection)
en-keyword=化学療法 (chemotherapy)
kn-keyword=化学療法 (chemotherapy)
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=1
article-no=
start-page=15
end-page=26
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Hypoglycemic activity of Momordica charantia (bitter melon)
kn-title=ニガウリ抽出物の血糖降下作用に関する文献的考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Diabetes mellitus (DM) represents a global health and economical problem. Many patients with DM in Asia, South America, India and East Africa have traditionally used the water extract of unripe fruits of Momordica charantia (bitter melon) as some form of complementary and alternative medicine. Studies of laboratory animals have shown the beneficial blood-glucose lowering and anti-diabetic effects of this remedy. Some oral components that bring lower blood glucose level have been isolated : charantin (sterol glycosides), charantin (polypeptide) and cucurbine-type triterpenes. Part of their actions are related to AMP-activated kinase and repression of the oxidative stress that is increased in DM. Most clinical reports are not fully convincing due to the lack of randomized control studies. The present article reviews the pharmacological and clinical effects of bitter melon with special emphasis on the anti-diabetic effects, and some effects that would require caution in the context of human trials.
en-copyright=
kn-copyright=

en-aut-name=MankuraMitsumasa
en-aut-sei=Mankura
en-aut-mei=Mitsumasa
kn-aut-name=万倉三正
kn-aut-sei=万倉
kn-aut-mei=三正
aut-affil-num=1
ORCID=

en-aut-name=NodaYasuko
en-aut-sei=Noda
en-aut-mei=Yasuko
kn-aut-name=野田泰子
kn-aut-sei=野田
kn-aut-mei=泰子
aut-affil-num=2
ORCID=

en-aut-name=MoriAkitane
en-aut-sei=Mori
en-aut-mei=Akitane
kn-aut-name=森昭胤
kn-aut-sei=森
kn-aut-mei=昭胤
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　医療薬学・先端薬物療法開発学

affil-num=2
en-affil=
kn-affil=岡山大学医学部　病原細菌学

affil-num=3
en-affil=
kn-affil=岡山大学
en-keyword=ニガウリ (bitter melon)
kn-keyword=ニガウリ (bitter melon)
en-keyword=Momordica charantia
kn-keyword=Momordica charantia
en-keyword=糖尿病 (diabetes mellitus)
kn-keyword=糖尿病 (diabetes mellitus)
en-keyword=酸化ストレス (oxidative stress)
kn-keyword=酸化ストレス (oxidative stress)
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=4
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Perinodal ECM―its role in diffusion barrier formation and conduction velocity in the CNS
kn-title=ランビエ絞輪周囲のECMによるdiffusion barrier形成と跳躍伝導における役割
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=BekkuYoko
en-aut-sei=Bekku
en-aut-mei=Yoko
kn-aut-name=別宮洋子
kn-aut-sei=別宮
kn-aut-mei=洋子
aut-affil-num=1
ORCID=

en-aut-name=NinomiyaYoshifumi
en-aut-sei=Ninomiya
en-aut-mei=Yoshifumi
kn-aut-name=二宮善文
kn-aut-sei=二宮
kn-aut-mei=善文
aut-affil-num=2
ORCID=

en-aut-name=OohashiToshitaka
en-aut-sei=Oohashi
en-aut-mei=Toshitaka
kn-aut-name=大橋俊孝
kn-aut-sei=大橋
kn-aut-mei=俊孝
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　分子医化学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　分子医化学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　分子医化学
en-keyword=proteoglycan
kn-keyword=proteoglycan
en-keyword=node of Ranvier
kn-keyword=node of Ranvier
en-keyword=action potential
kn-keyword=action potential
en-keyword=extracellular space
kn-keyword=extracellular space
en-keyword=diffusion barrier
kn-keyword=diffusion barrier
END

start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=1
article-no=
start-page=18
end-page=26
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=1994
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Effect of Endotoxin on the Neutrophil Chemiluminescence in the Rabbit
kn-title=エンドトキシン血症家兎の好中球化学発光の変動
en-subtitle=
kn-subtitle=
en-abstract=To examine the effects of endotoxin on the neutrophil function, neutrophil-dependent microbicidal activities were evaluated by the chemiluminescence (CL) method in rabbits injected with endotoxin. Six rabbits in the first group were administered saline intravenously as control. Ten rabbits each in the second and third group received endotoxin 0.7 μg・kg(-1) and 70 μg・kg(-1) respectively. Luminol-dependent CL in whole blood (whole blood CL) and in isolated neutrophils (neutrophil CL) were examined before administration and 30, 60, 180 and 360 min after administration. Peak values of whole blood CL in the second group were significantly depressed at 30 and 60 min, and elevated at 360 min. Those in the third group were depressed more than in the second group at all times after endotoxin administration. Peak values of neutrophil CL in the second group at 180 and 360 min were significantly elevated, but those in the third group at 30, 60, 180 min were markedly depressed. Experiments combining neutrophils and pooled plasma revealed that these CL responses were associated with the neutrophils themselves. It is speculated that the neutrophil supression observed in the third group was caused by the overactivation of ncutrophils induced by the activated complements and some other stimulating factors, and/or may be due to the abundant appearance of immature granulocytes with lesser activities.
kn-abstract=好中球の貪食殺菌能を調べる方法として，増感剤を用いた化学発光(CL)法がある。好中球CLは細菌感染によって増大するが,重症感染症になると低下する場合がある。重症の細菌感染症における好中球CLの低下の原因を探るために，家兎に高濃度(70μg･kg(-1):III群)あるいは低濃度エンドトキシン(0.7μg･kg(-1):II群)を一回静注し，好中球の貪食殺菌能をCL法によって経時的に測定した。好中球を用いたCLピーク値は，II群では180分，360分で有意の上昇が認められ，III群では30分，60分，180分で有意の低下が認められた。好中球とプール血漿を組み合わせてCLを測定したところ，類似した結果が得られたため，好中球側に原因があることが示唆された。全血を用いたCLピーク値と白血球数とは類似の変化を示し，30分で有意に低下し，60分で最低を示したのちに回復した。以上より,軽度のエンドトキシン血症時には，好中球自体の貪食殺菌能が亢進する。しかし，重症エンドトキシン血症時には好中球数減少に伴う生体側の殺菌能の低下のほかに，好中球自体の貪食殺菌能の抑制が起こることが示された。
en-copyright=
kn-copyright=

en-aut-name=AsaoYasuhiro
en-aut-sei=Asao
en-aut-mei=Yasuhiro
kn-aut-name=浅雄保宏
kn-aut-sei=浅雄
kn-aut-mei=保宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔･蘇生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=2
article-no=
start-page=271
end-page=279
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=子宮頸部腺癌広汎全摘例における術前動注化学療法の有用性に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=廣瀬徹
kn-aut-sei=廣瀬
kn-aut-mei=徹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=
dt-pub=
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=高濃度ギ酸から水素を製造する化学触媒法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OshikiToshiyuki
en-aut-sei=Oshiki
en-aut-mei=Toshiyuki
kn-aut-name=押木俊之
kn-aut-sei=押木
kn-aut-mei=俊之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻
END