start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=116
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250416
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Colorectal cancer (CRC) is considered the third most common type of cancer worldwide. Tumor-associated macrophages (TAMs) have been shown to promote drug resistance. Adenosine-to-inosine RNA-editing, as regulated by adenosine deaminase acting on RNA (ADAR), is a process that induces the posttranscriptional modification of critical oncogenes. The aim of this study is to determine whether the signals from cancer cells would induce RNA-editing in macrophages.<br>
Methods The effects of RNA-editing on phenotypes in macrophages were analyzed using clinical samples and in vitro and in vivo models.<br>
Results The intensity of the RNA-editing enzyme ADAR1 (Adenosine deaminase acting on RNA 1) in cancer and mononuclear cells indicated a strong positive correlation between the nucleus and cytoplasm. The ADAR1-positive mononuclear cells were positive for CD68 and CD163, a marker for M2 macrophages. Cancer cells transport pro-inflammatory cytokines or ADAR1 protein directly to macrophages via the exosomes, promoting RNA-editing in AZIN1 (Antizyme Inhibitor 1) and GLI1 (Glioma-Associated Oncogene Homolog 1) and resulting in M2 macrophage polarization. GLI1 RNA-editing in the macrophages induced by cancer cells promotes the secretion of SPP1, which is supplied to the cancer cells. This activates the NF kappa B pathway in cancer cells, promoting oxaliplatin resistance. When the JAK inhibitors were administered, oncogenic RNA-editing in the macrophages was suppressed. This altered the macrophage polarization from M2 to M1 and decreased oxaliplatin resistance in cancer cells.<br>
Conclusions This study revealed that ADAR1-high TAMs are crucial in regulating drug resistance in CRC and that targeting ADAR1 in TAMs could be a promising treatment approach for overcoming drug resistance in CRC.
en-copyright=
kn-copyright=

en-aut-name=UmedaHibiki
en-aut-sei=Umeda
en-aut-mei=Hibiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShigeyasuKunitoshi
en-aut-sei=Shigeyasu
en-aut-mei=Kunitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakahashiToshiaki
en-aut-sei=Takahashi
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoriwakeKazuya
en-aut-sei=Moriwake
en-aut-mei=Kazuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KondoYoshitaka
en-aut-sei=Kondo
en-aut-mei=Yoshitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YoshidaKazuhiro
en-aut-sei=Yoshida
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakedaSho
en-aut-sei=Takeda
en-aut-mei=Sho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YanoShuya
en-aut-sei=Yano
en-aut-mei=Shuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MatsumiYuki
en-aut-sei=Matsumi
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KishimotoHiroyuki
en-aut-sei=Kishimoto
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=FujiTomokazu
en-aut-sei=Fuji
en-aut-mei=Tomokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=YasuiKazuya
en-aut-sei=Yasui
en-aut-mei=Kazuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=YamamotoHideki
en-aut-sei=Yamamoto
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=TakagiKosei
en-aut-sei=Takagi
en-aut-mei=Kosei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KayanoMasashi
en-aut-sei=Kayano
en-aut-mei=Masashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=MichiueHiroyuki
en-aut-sei=Michiue
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=NakamuraKeiichiro
en-aut-sei=Nakamura
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=MoriYoshiko
en-aut-sei=Mori
en-aut-mei=Yoshiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=TeraishiFuminori
en-aut-sei=Teraishi
en-aut-mei=Fuminori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=TazawaHiroshi
en-aut-sei=Tazawa
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=UmedaYuzo
en-aut-sei=Umeda
en-aut-mei=Yuzo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=GoelAjay
en-aut-sei=Goel
en-aut-mei=Ajay
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=24
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=15
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=16
en-affil=Neutron Therapy Research Center, Okayama University
kn-affil=

affil-num=17
en-affil=Department of Obstetrics and Gynecology, Okayama University Gradu�ate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=18
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=19
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=20
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=21
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=22
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=23
en-affil=Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute, City of Hope Comprehensive Cancer Center
kn-affil=

affil-num=24
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=RNA-editing
kn-keyword=RNA-editing
en-keyword=Macrophage
kn-keyword=Macrophage
en-keyword=Chemoresistance
kn-keyword=Chemoresistance
en-keyword=Biomarker
kn-keyword=Biomarker
en-keyword=Colorectal cancer
kn-keyword=Colorectal cancer
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=奥付
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=97
end-page=122
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Transition from Pit Structures to Surface Structures ― Comparing Japan with other Pit Dwelling Societies
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WESTStephen
en-aut-sei=WEST
en-aut-mei=Stephen
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences (Doctor's Course), Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=75
end-page=96
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the Difference between Japanese Language Textbooks Published in Japan and China ― The Aspect of Vocabulary
kn-title=日本と中国で出版された日本語教科書の比較研究―収録語彙の側面から―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=LUJianhui
en-aut-sei=LU
en-aut-mei=Jianhui
kn-aut-name=呂建輝
kn-aut-sei=呂
kn-aut-mei=建輝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学学術研究院社会文化科学学域
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=49
end-page=73
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Mechanism in Leibniz from a Medical-Philosophical Point of View
kn-title=ライプニッツの機械論―医学哲学的観点から
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MATSUDATsuyoshi
en-aut-sei=MATSUDA
en-aut-mei=Tsuyoshi
kn-aut-name=松田毅
kn-aut-sei=松田
kn-aut-mei=毅
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=33
end-page=48
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the Media Coverage of the State Visit to Holland in 2000 ― The Empress’s White Chrysanthemum
kn-title=2000年天皇訪蘭にかんするメディア報道について―「皇后さまと白い菊」―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NAKAOTomoyo
en-aut-sei=NAKAO
en-aut-mei=Tomoyo
kn-aut-name=中尾知代
kn-aut-sei=中尾
kn-aut-mei=知代
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=23
end-page=32
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ethical Life as “Living Good”: In Comparison with the Thought of the Young Hegel
kn-title=「生ける善」としての人倫―初期ヘーゲルの視点から―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TAKESHIMAAyumi
en-aut-sei=TAKESHIMA
en-aut-mei=Ayumi
kn-aut-name=竹島あゆみ
kn-aut-sei=竹島
kn-aut-mei=あゆみ
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=1
end-page=21
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Japanese “Ejaculate Responsibly”: Issues Raised, Responses, Succession
kn-title=日本の「射精責任」論―問題提起、応答、継承―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SAITOKeisuke
en-aut-sei=SAITO
en-aut-mei=Keisuke
kn-aut-name=齋藤圭介
kn-aut-sei=齋藤
kn-aut-mei=圭介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=学術研究院　社会文化科学学域
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=23
article-no=
start-page=7428
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241121
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Design and Implementation of Kerberos-Blockchain Vehicular Ad-Hoc Networks Authentication Across Diverse Network Scenarios
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Vehicular Ad-Hoc Networks (VANETs) play an essential role in the intelligent transportation era, furnishing users with essential roadway data to facilitate optimal route selection and mitigate the risk of accidents. However, the network exposure makes VANETs susceptible to cyber threats, making authentication crucial for ensuring security and integrity. Therefore, joining entity verification is essential to ensure the integrity and security of communication in VANETs. However, to authenticate the entities, authentication time should be minimized to guarantee fast and secure authentication procedures. We propose an authentication system for VANETs using blockchain and Kerberos for storing authentication messages in a blockchain ledger accessible to Trusted Authentication Servers (TASs) and Roadside Units (RSUs). We evaluate the system in three diverse network scenarios: suburban, urban with 1 TAS, and urban with 2 TASs. The findings reveal that this proposal is applicable in diverse network scenarios to fulfill the network requirements, including authentication, handover, and end-to-end delay, considering an additional TAS for an increasing number of vehicles. The system is also practicable in storing the authentication message in blockchain considering the gas values and memory size for all scenarios.
en-copyright=
kn-copyright=

en-aut-name=RahayuMaya
en-aut-sei=Rahayu
en-aut-mei=Maya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HossainMd. Biplob
en-aut-sei=Hossain
en-aut-mei=Md. Biplob
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HudaSamsul
en-aut-sei=Huda
en-aut-mei=Samsul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KoderaYuta
en-aut-sei=Kodera
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AliMd. Arshad
en-aut-sei=Ali
en-aut-mei=Md. Arshad
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NogamiYasuyuki
en-aut-sei=Nogami
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Green Innovation Center, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Faculty of CSE, Hajee Mohammad Danesh Science and Technology University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Vehicular Ad-Hoc Network
kn-keyword=Vehicular Ad-Hoc Network
en-keyword=Kerberos authentication
kn-keyword=Kerberos authentication
en-keyword=blockchain
kn-keyword=blockchain
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=22
article-no=
start-page=7382
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241119
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Microdetection of Nucleocapsid Proteins via Terahertz Chemical Microscope Using Aptamers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several methods have been employed, including the detection of viral ribonucleic acid (RNA), nucleocapsid (N) proteins, spike proteins, and antibodies. RNA detection, primarily through polymerase chain reaction tests, targets the viral genetic material, whereas antigen tests detect N and spike proteins to identify active infections. In addition, antibody tests are performed to measure the immune response, indicating previous exposure or vaccination. Here, we used the developed terahertz chemical microscope (TCM) to detect different concentrations of N protein in solution by immobilizing aptamers on a semiconductor substrate (sensing plate) and demonstrated that the terahertz amplitude varies as the concentration of N proteins increases, exhibiting a highly linear relationship with a coefficient of determination (R2 = 0.9881), indicating that a quantitative measurement of N proteins is achieved. By optimizing the reaction conditions, we confirmed that the amplitude of the terahertz wave was independent of the solution volume. Consequently, trace amounts (0.5 μL) of the N protein were successfully detected, and the detection process only took 10 min. Therefore, this study is expected to develop a rapid and sensitive method for the detection and observation of the SARS-CoV-2 virus at a microdetection level. It is anticipated that this research will significantly contribute to reducing the spread of novel infectious diseases in the future.
en-copyright=
kn-copyright=

en-aut-name=DingXue
en-aut-sei=Ding
en-aut-mei=Xue
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MurakamiMana
en-aut-sei=Murakami
en-aut-mei=Mana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangJin
en-aut-sei=Wang
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=InoueHirofumi
en-aut-sei=Inoue
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KiwaToshihiko
en-aut-sei=Kiwa
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=terahertz chemical microscope
kn-keyword=terahertz chemical microscope
en-keyword=aptamers
kn-keyword=aptamers
en-keyword=N protein
kn-keyword=N protein
en-keyword=microdetection
kn-keyword=microdetection
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=366
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241120
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The required experience of open pancreaticoduodenectomy before becoming a specialist in hepatobiliary and pancreatic surgeons: a multicenter, cohort study of 334 open pancreaticoduodenectomies
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Open pancreaticoduodenectomy (OPD) is an essential surgical procedure for expert hepato-biliary-pancreatic (HBP) surgeons. However, there is no standard for how many surgeries must be performed by a surgeon in training before they are considered to have enough experience to ensure surgical safety. <br>
Methods Cumulative Sum (CUSUM) analysis was performed using the surgical data of OPDs performed during the training period of board-certified expert surgeons of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. <br>
Results Fourteen HBP surgeons participated in this study and performed 334 OPDs during their training period. The median (interquartile range) values for operative time, blood loss, and length of hospital stay were 455 (397-519) minutes, 450 (234--716) ml, and 28 (21-38) days, respectively. CUSUM analysis showed inflection points at 20 surgeries performed for operative time. After 20 procedures, operative time was significantly shorter (461 min vs. 425 min, p = 0.021) and blood loss was significantly lower (470 ml vs. 340 ml, p = 0.038). No significant differences between within 20 and after 21 procedures were found in the complication rate (53% vs. 48%, p = 0.424) and rate of in-hospital deaths (1.5% vs.1.4%. p = 0.945). Up to 20 surgeries, PDAC and another malignant tumor had longer operative time than benign/low malignant diseases (486 min vs. 472 min vs. 429 min, p < 0.001), and higher blood loss (500 ml vs. 502 ml vs. 355 ml, p < 0.001). Mortality rate was higher at PDAC cases (5% vs. 0% vs. 0%, p = 0.01). After the 21 procedures, these outcomes were improved and no differences in by primary disease were observed. Multivariable analysis showed that within 20 surgeries were independent risk factors of longer operative time (HR2.6, p = 0.013) and higher blood loss (HR2.0, p = 0.049). <br>
Conclusions To stabilize the surgical outcome of OPD for malignant disease, at least 20 surgeries should be performed at a certified institution during surgeon training. Trial registrationClinical trial number: Not applicable.
en-copyright=
kn-copyright=

en-aut-name=FujiTomokazu
en-aut-sei=Fuji
en-aut-mei=Tomokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UmedaYuzo
en-aut-sei=Umeda
en-aut-mei=Yuzo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakagiKosei
en-aut-sei=Takagi
en-aut-mei=Kosei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HiokiMasayoshi
en-aut-sei=Hioki
en-aut-mei=Masayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshidaRyuichi
en-aut-sei=Yoshida
en-aut-mei=Ryuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=EndoYoshikatsu
en-aut-sei=Endo
en-aut-mei=Yoshikatsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YasuiKazuya
en-aut-sei=Yasui
en-aut-mei=Kazuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NobuokaDaisuke
en-aut-sei=Nobuoka
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterological Surgery Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Surgery, Fukuyama City Hospital
kn-affil=

affil-num=5
en-affil=Department of surgery, Hiroshima Citizens Hiroshima Citizens Hospital
kn-affil=

affil-num=6
en-affil=Department of Surgery, Japanese Red Cross Society Himeji Hospital
kn-affil=

affil-num=7
en-affil=Department of Gastroenterological Surgery Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterological Surgery, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=9
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Gastroenterological Surgery Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Education
kn-keyword=Education
en-keyword=High-volume hospital
kn-keyword=High-volume hospital
en-keyword=Learning curve
kn-keyword=Learning curve
en-keyword=Pancreaticoduodenectomy
kn-keyword=Pancreaticoduodenectomy
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=foae032
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241018
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Improving the Z3EV promoter system to create the strongest yeast promoter
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Promoters for artificial control of gene expression are central tools in genetic engineering. In the budding yeast Saccharomyces cerevisiae, a variety of constitutive and controllable promoters with different strengths have been constructed using endogenous gene promoters, synthetic transcription factors and their binding sequences, and artificial sequences. However, there have been no attempts to construct the highest strength promoter in yeast cells. In this study, by incrementally increasing the binding sequences of the synthetic transcription factor Z3EV, we were able to construct a promoter (P36) with ~1.4 times the strength of the TDH3 promoter. This is stronger than any previously reported promoter. Although the P36 promoter exhibits some leakage in the absence of induction, the expression induction by estradiol is maintained. When combined with a multicopy plasmid, it can express up to ~50% of total protein as a heterologous protein. This promoter system can be used to gain knowledge about the cell physiology resulting from the ultimate overexpression of excess proteins and is expected to be a useful tool for heterologous protein expression in yeast.
en-copyright=
kn-copyright=

en-aut-name=HiguchiRina
en-aut-sei=Higuchi
en-aut-mei=Rina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujitaYuri
en-aut-sei=Fujita
en-aut-mei=Yuri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NambaShotaro
en-aut-sei=Namba
en-aut-mei=Shotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoriyaHisao
en-aut-sei=Moriya
en-aut-mei=Hisao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=yeast
kn-keyword=yeast
en-keyword=overexpression
kn-keyword=overexpression
en-keyword=promoter
kn-keyword=promoter
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=1099
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240916
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Histological differences related to autophagy in the minor salivary gland between primary and secondary types of Sjögren's syndrome
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Some forms of Sjögren’s syndrome (SS) follow a clinical course accompanied by systemic symptoms caused by lymphocyte infiltration and proliferation in the liver, kidneys, and other organs. To better understand the clinical outcomes of SS, here we used minor salivary gland tissues from patients and examine their molecular, biological, and pathological characteristics. A retrospective study was performed, combining clinical data and formalin-fixed paraffin-embedded (FFPE) samples from female patients over 60 years of age who underwent biopsies at Okayama University Hospital. We employed direct digital RNA counting with nCounter® and multiplex immunofluorescence analysis with a PhenoCycler™ on the labial gland biopsies. We compared FFPE samples from SS patients who presented with other connective tissue diseases (secondary SS) with those from stable SS patients with symptoms restricted to the exocrine glands (primary SS). Secondary SS tissues showed enhanced epithelial damage and lymphocytic infiltration accompanied by elevated expression of autophagy marker genes in the immune cells of the labial glands. The close intercellular distance between helper T cells and B cells positive for autophagy-associated molecules suggests accelerated autophagy in these lymphocytes and potential B cell activation by helper T cells. These findings indicate that examination of FFPE samples from labial gland biopsies can be an effective tool for evaluating molecular histological differences between secondary and primary SS through multiplexed analysis of gene expression and tissue imaging.
en-copyright=
kn-copyright=

en-aut-name=Ono-MinagiHitomi
en-aut-sei=Ono-Minagi
en-aut-mei=Hitomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NohnoTsutomu
en-aut-sei=Nohno
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakabatakeKiyofumi
en-aut-sei=Takabatake
en-aut-mei=Kiyofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KatsuyamaTakayuki
en-aut-sei=Katsuyama
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyawakiKohta
en-aut-sei=Miyawaki
en-aut-mei=Kohta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IidaSeiji
en-aut-sei=Iida
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YoshinoTadashi
en-aut-sei=Yoshino
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SakaiTakayoshi
en-aut-sei=Sakai
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=OhuchiHideyo
en-aut-sei=Ohuchi
en-aut-mei=Hideyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Cytology and Histology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Cytology and Histology, Okayama University Medical School
kn-affil=

affil-num=3
en-affil=Department of Oral Pathology and Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Pathology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Division of Precision Medicine, Kyushu University School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Pathology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=11
en-affil=Department of Oral Pathology and Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Rehabilitation for Orofacial Disorders, Osaka University Graduate School of Dentistry
kn-affil=

affil-num=13
en-affil=Department of Cytology and Histology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Autoimmune disease
kn-keyword=Autoimmune disease
en-keyword=Xerostomia
kn-keyword=Xerostomia
en-keyword=Multiplex immunostaining
kn-keyword=Multiplex immunostaining
en-keyword=Spatial analysis
kn-keyword=Spatial analysis
en-keyword=Autophagy
kn-keyword=Autophagy
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=542
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240815
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluating the impact of a trial of labor after cesarean section on labor duration: a retrospective cohort study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Cesarean section (C-section) rates are increasing globally, and repeated C-sections are associated with increased maternal morbidity. Trial of labor after C-section (TOLAC) is an approach to reduce the recurrence of C-sections. However, limited research exists on the impact of cesarean scars on labor duration in TOLAC, considering the termination of labor through C-section and selection bias. This study aimed to investigate the impact of cesarean scars on labor duration in TOLAC participants, accounting for potential confounding factors and biases. <br>
Methods This retrospective cohort study included 2,964 women who attempted vaginal birth at a single center in Japan from 2012 to 2021. The study categorized participants into TOLAC (n = 187) and non-TOLAC (n = 2,777) groups. Propensity scores were calculated based on 14 factors that could influence labor duration, and inverse probability of treatment weighting (IPTW) was applied. Cox proportional hazards regression analysis estimated hazard ratios (HRs) for labor duration, with and without IPTW adjustment. Sensitivity analyses used propensity score matching, bootstrapping, and interval censoring to address potential biases, including recall bias in the reported onset of labor.<br>
Results The unadjusted HR for labor duration in the TOLAC group compared to the non-TOLAC group was 0.83 (95% CI: 0.70-0.98, P = 0.027), indicating a longer labor duration in the TOLAC group. After adjusting for confounding factors using IPTW, the HR was 0.98 (95% CI: 0.74-1.30, P = 0.91), suggesting no significant difference in labor duration between the groups. Sensitivity analyses using propensity score matching, bootstrapping, and interval censoring yielded consistent results. These findings suggested that the apparent association between TOLAC and longer labor duration was because of confounding factors rather than TOLAC itself.<br>
Conclusions After adjusting for confounding factors and addressing potential biases, cesarean scars had a limited impact on labor duration in TOLAC participants. Maternal and fetal characteristics may have a more substantial influence on labor duration.
en-copyright=
kn-copyright=

en-aut-name=OobaHikaru
en-aut-sei=Ooba
en-aut-mei=Hikaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MakiJota
en-aut-sei=Maki
en-aut-mei=Jota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MasuyamaHisashi
en-aut-sei=Masuyama
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Obstetrics and Gynecology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Obstetrics and Gynecology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Obstetrics and Gynecology, Okayama University Hospital
kn-affil=
en-keyword=Labor duration
kn-keyword=Labor duration
en-keyword=Trial of labor after cesarean section
kn-keyword=Trial of labor after cesarean section
en-keyword=Vaginal birth
kn-keyword=Vaginal birth
en-keyword=Cesarean section
kn-keyword=Cesarean section
en-keyword=Propensity scores
kn-keyword=Propensity scores
en-keyword=IPTW
kn-keyword=IPTW
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=341
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240813
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Pathological findings in enucleated eyes of patients with neurofibromatosis type 1: report of a case with 15-year follow-up and review of 14 patients in the literature
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Backgrounds Iris nodules are frequently noted as clinical manifestations of neurofibromatosis type 1 but the other intraocular manifestations are rare. The purpose of this study is to present a patient with a phthisic eye who underwent enucleation for a cosmetic reason after 15-year follow-up and also to review 14 patients with enucleation described in the literature.<br>
Case presentation A 17-year-old man with neurofibromatosis type 1 from infancy underwent the enucleation of phthisic left eye and also had the resection of eyelid subcutaneous mass lesions on the left side for a cosmetic reason. He had undergone four-time preceding surgeries for eyelid and orbital mass reduction on the left side in childhood and had developed total retinal detachment 10 years previously. Pathologically, the enucleated eye showed massive retinal gliosis positive for both S-100 and glial fibrillary acidic protein (GFAP) in the area with involvement of the detached retinal neuronal layer, together with a more fibrotic lesion along the choroid which were, in contrast, negative for both S-100 and GFAP. The choroid, ciliary body, and iris did not show apparent neurofibroma while episcleral neurofibroma was present.<br>
Literature review In review of enucleated eyes of 14 patients in the literature, buphthalmic eyes with early-onset glaucoma on the unilateral side was clinically diagnosed in 9 patients who frequently showed varying extent of hemifacial neurofibromatosis which involved the eyelid and orbit on the same side. Pathologically, neurofibromas in varying extent were found in the choroid of 12 patients. One patient showed choroidal malignant melanoma on the left side and fusiform enlargement of the optic nerve on the right side suspected of optic nerve glioma. The phthisic eye in another patient showed massive retinal gliosis similar to the present patient.<br>
Conclusions In summary of the 15 patients with neurofibromatosis type 1, including the present patient, buphthalmic or phthisic eyes with no vision were enucleated for cosmetic reasons and showed choroidal neurofibroma in most patients and massive retinal gliosis in two patients including the present patient.
en-copyright=
kn-copyright=

en-aut-name=MatsuoToshihiko
en-aut-sei=Matsuo
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishidaKenji
en-aut-sei=Nishida
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SenoTakaya
en-aut-sei=Seno
en-aut-mei=Takaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamadaKiyoshi
en-aut-sei=Yamada
en-aut-mei=Kiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OnoShigeki
en-aut-sei=Ono
en-aut-mei=Shigeki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Pathology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Pathology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Neurological Surgery, General Medical Center, Kawasaki Medical School
kn-affil=
en-keyword=Neurofibromatosis type 1
kn-keyword=Neurofibromatosis type 1
en-keyword=Enucleation
kn-keyword=Enucleation
en-keyword=Eye
kn-keyword=Eye
en-keyword=Pathology
kn-keyword=Pathology
en-keyword=Massive retinal gliosis
kn-keyword=Massive retinal gliosis
en-keyword=Choroidal neurofibroma
kn-keyword=Choroidal neurofibroma
en-keyword=Phthisis
kn-keyword=Phthisis
en-keyword=Buphthalmos
kn-keyword=Buphthalmos
en-keyword=Malignant melanoma
kn-keyword=Malignant melanoma
en-keyword=Cosmetic surgery
kn-keyword=Cosmetic surgery
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=13
article-no=
start-page=4293
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240701
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Optimizing IoT Intrusion Detection Using Balanced Class Distribution, Feature Selection, and Ensemble Machine Learning Techniques
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Internet of Things (IoT) devices are leading to advancements in innovation, efficiency, and sustainability across various industries. However, as the number of connected IoT devices increases, the risk of intrusion becomes a major concern in IoT security. To prevent intrusions, it is crucial to implement intrusion detection systems (IDSs) that can detect and prevent such attacks. IDSs are a critical component of cybersecurity infrastructure. They are designed to detect and respond to malicious activities within a network or system. Traditional IDS methods rely on predefined signatures or rules to identify known threats, but these techniques may struggle to detect novel or sophisticated attacks. The implementation of IDSs with machine learning (ML) and deep learning (DL) techniques has been proposed to improve IDSs' ability to detect attacks. This will enhance overall cybersecurity posture and resilience. However, ML and DL techniques face several issues that may impact the models' performance and effectiveness, such as overfitting and the effects of unimportant features on finding meaningful patterns. To ensure better performance and reliability of machine learning models in IDSs when dealing with new and unseen threats, the models need to be optimized. This can be done by addressing overfitting and implementing feature selection. In this paper, we propose a scheme to optimize IoT intrusion detection by using class balancing and feature selection for preprocessing. We evaluated the experiment on the UNSW-NB15 dataset and the NSL-KD dataset by implementing two different ensemble models: one using a support vector machine (SVM) with bagging and another using long short-term memory (LSTM) with stacking. The results of the performance and the confusion matrix show that the LSTM stacking with analysis of variance (ANOVA) feature selection model is a superior model for classifying network attacks. It has remarkable accuracies of 96.92% and 99.77% and overfitting values of 0.33% and 0.04% on the two datasets, respectively. The model's ROC is also shaped with a sharp bend, with AUC values of 0.9665 and 0.9971 for the UNSW-NB15 dataset and the NSL-KD dataset, respectively.
en-copyright=
kn-copyright=

en-aut-name=MusthafaMuhammad Bisri
en-aut-sei=Musthafa
en-aut-mei=Muhammad Bisri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HudaSamsul
en-aut-sei=Huda
en-aut-mei=Samsul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KoderaYuta
en-aut-sei=Kodera
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AliMd. Arshad
en-aut-sei=Ali
en-aut-mei=Md. Arshad
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ArakiShunsuke
en-aut-sei=Araki
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MwauraJedidah
en-aut-sei=Mwaura
en-aut-mei=Jedidah
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NogamiYasuyuki
en-aut-sei=Nogami
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Green Innovation Center, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Faculty of CSE, Hajee Mohammad Danesh Science and Technology University
kn-affil=

affil-num=5
en-affil=Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology
kn-affil=

affil-num=6
en-affil=Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=intrusion detection system
kn-keyword=intrusion detection system
en-keyword=feature selection
kn-keyword=feature selection
en-keyword=class balancing
kn-keyword=class balancing
en-keyword=ensemble technique
kn-keyword=ensemble technique
en-keyword=stacked long short-term memory
kn-keyword=stacked long short-term memory
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=140
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240422
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Endoscopic manifestation of intestinal transplant-associated microangiopathy after stem cell transplantation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Endoscopic features of intestinal transplant-associated microangiopathy (iTAM) have not been comprehensively investigated. This study aimed to examine the endoscopic characteristics of patients diagnosed with iTAM.<br>
Methods This retrospective analysis included 14 patients pathologically diagnosed with iTAM after stem cell transplantation for hematolymphoid neoplasms (n = 13) or thalassemia (n = 1). The sex, age at diagnosis, endoscopic features, and prognosis of each patient were assessed. Serological markers for diagnosing transplant-associated thrombotic microangiopathy were also evaluated.<br>
Results The mean age at the time of iTAM diagnosis was 40.2 years. Patients diagnosed based on the pathognomonic pathological changes of iTAM presented with diverse symptoms at the times of endoscopic examinations, including diarrhea (n = 10), abdominal pain (n = 5), nausea (n = 4), appetite loss (n = 2), bloody stools (n = 2), abdominal discomfort (n = 1), and vomiting (n = 1). At the final follow-up, six patients survived, while eight patients succumbed, with a median time of 100.5 days (range: 52-247) post-diagnosis. Endoscopic manifestations included erythematous mucosa (n = 14), erosions (n = 13), ulcers (n = 9), mucosal edema (n = 9), granular mucosa (n = 9), and villous atrophy (n = 4). Erosions and/or ulcers were primarily observed in the colon (10/14, 71%), followed by the ileum (9/13, 69%), stomach (4/10, 40%), cecum (5/14, 36%), duodenum (3/10, 30%), rectum (4/14, 29%), and esophagus (1/10, 10%). Cytomegalovirus infection (n = 4) and graft-versus-host disease (n = 2) coexisted within the gastrointestinal tract. Patients had de novo prolonged or progressive thrombocytopenia (6/14, 43%), decreased hemoglobin concentration (4/14, 29%), reduced serum haptoglobin level (3/14, 21%), and a sudden and persistent increase in lactate dehydrogenase level (2/14, 14%). Peripheral blood samples from 12 patients were evaluated for schistocytes, with none exceeding 4%.<br>
Conclusions This study provides a comprehensive exploration of the endoscopic characteristics of iTAM. Notably, all patients exhibited erythematous mucosa throughout the gastrointestinal tract, accompanied by prevalent manifestations, such as erosions (93%), ulcers (64%), mucosal edema (64%), granular mucosa (64%), and villous atrophy (29%). Because of the low positivity for serological markers of transplant-associated thrombotic microangiopathy in patients with iTAM, endoscopic evaluation and biopsy of these lesions are crucial, even in the absence of these serological features.
en-copyright=
kn-copyright=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=EnnishiDaisuke
en-aut-sei=Ennishi
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiiNobuharu
en-aut-sei=Fujii
en-aut-mei=Nobuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsuokaKen-Ichi
en-aut-sei=Matsuoka
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=InokuchiToshihiro
en-aut-sei=Inokuchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HiraokaSakiko
en-aut-sei=Hiraoka
en-aut-mei=Sakiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OtsukaMotoyuki
en-aut-sei=Otsuka
en-aut-mei=Motoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Hematology and Oncology, Okayama University  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Hematology and Oncology, Okayama University  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hematology and Oncology, Okayama University  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Pathology, Okayama University Graduate School of  Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University  Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Colonoscopy
kn-keyword=Colonoscopy
en-keyword=Esophagogastroduodenoscopy
kn-keyword=Esophagogastroduodenoscopy
en-keyword=Graft-versus-host disease
kn-keyword=Graft-versus-host disease
en-keyword=Hematopoietic stem cell transplantation
kn-keyword=Hematopoietic stem cell transplantation
en-keyword=Intestinal transplant-associated microangiopathy
kn-keyword=Intestinal transplant-associated microangiopathy
en-keyword=iTAM
kn-keyword=iTAM
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=7
article-no=
start-page=2173
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240328
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Application of Throughput Request Satisfaction Method for Maximizing Concurrent Throughput in WLAN for IoT Application System
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the wide applications of the Internet of Things (IoT) in smart home systems, IEEE 802.11n Wireless Local Area Networks (WLANs) have become a frequently chosen communication technology due to their adaptability and affordability. In a high-density network of devices such as the smart home scenerio, a host often meets interferences from other devices and unequal Received Signal Strength (RSS) from Access Points (APs). This results in throughput unfairness/insufficiency problems between hosts communicating concurrently in WLAN. Previously, we have studied the throughput request satisfaction method to address this problem. It calculates the target throughput from measured single and concurrent throughputs of hosts and controls the actual throughput at this target one by applying traffic shaping at the AP. However, the insufficiency problem of maximizing the throughput is not solved due to interferences from other hosts. In this paper, we present an extension of the throughput request satisfaction method to maximize the throughput of a high-priority host under concurrent communications. It recalculates the target throughput to increase the actual throughput as much as possible while the other hosts satisfy the least throughput. For evaluations, we conduct experiments using the test-bed system with Raspberry Pi as the AP devices in several topologies in indoor environments. The results confirm the effectiveness of our proposal.
en-copyright=
kn-copyright=

en-aut-name=WuBin
en-aut-sei=Wu
en-aut-mei=Bin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FunabikiNobuo
en-aut-sei=Funabiki
en-aut-mei=Nobuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=RoySujan Chandra
en-aut-sei=Roy
en-aut-mei=Sujan Chandra
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=RahmanMd. Mahbubur
en-aut-sei=Rahman
en-aut-mei=Md. Mahbubur
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KongDezheng
en-aut-sei=Kong
en-aut-mei=Dezheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FangShihao
en-aut-sei=Fang
en-aut-mei=Shihao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Raspberry Pi
kn-keyword=Raspberry Pi
en-keyword=WLAN
kn-keyword=WLAN
en-keyword=traffic shaping
kn-keyword=traffic shaping
en-keyword=access point
kn-keyword=access point
en-keyword=target throughput
kn-keyword=target throughput
en-keyword=throughput maximization
kn-keyword=throughput maximization
en-keyword=high-density IoT networks
kn-keyword=high-density IoT networks
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=257
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240315
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Long-term, patient-centered, frailty-based outcomes of older critical illness survivors from the emergency department: a post hoc analysis of the LIFE Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Evidence indicates frailty before intensive care unit (ICU) admission leads to poor outcomes. However, it is unclear whether quality of life (QOL) and activities of daily living (ADL) for survivors of critical illness admitted to the ICU via the emergency department remain consistent or deteriorate in the long-term compared to baseline. This study aimed to evaluate long-term QOL/ADL outcomes in these patients, categorized by the presence or absence of frailty according to Clinical Frailty Scale (CFS) score, as well as explore factors that influence these outcomes.<br>
Methods This was a post-hoc analysis of a prospective, multicenter, observational study conducted across Japan. It included survivors aged 65 years or older who were admitted to the ICU through the emergency department. Based on CFS scores, participants were categorized into either the not frail group or the frail group, using a threshold CFS score of < 4. Our primary outcome was patient-centered outcomes (QOL/ADL) measured by the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) and the Barthel Index six months post-ICU admission, comparing results from baseline. Secondary outcomes included exploration of factors associated with QOL/ADL six months post-ICU admission using multiple linear regression analyses.<br>
Results Of 514 candidates, 390 participants responded to the EQ-5D-5L questionnaire, while 237 responded to the Barthel Index. At six months post-admission, mean EQ-5D-5L values declined in both the not frail and frail groups (0.80 to 0.73, p = 0.003 and 0.58 to 0.50, p = 0.002, respectively); Barthel Index scores also declined in both groups (98 to 83, p < 0.001 and 79 to 61, p < 0.001, respectively). Multiple linear regression analysis revealed that baseline frailty (β coefficient, -0.15; 95% CI, − 0.23 to − 0.07; p < 0.001) and pre-admission EQ-5D-5L scores (β coefficient, 0.14; 95% CI, 0.02 to 0.26; p = 0.016) affected EQ-5D-5L scores at six months. Similarly, baseline frailty (β coefficient, -12.3; 95% CI, − 23.9 to − 0.80; p = 0.036) and Barthel Index scores (β coefficient, 0.54; 95% CI, 0.30 to 0.79; p < 0.001) influenced the Barthel Index score at six months.<br>
Conclusions Regardless of frailty, older ICU survivors from the emergency department were more likely to experience reduced QOL and ADL six months after ICU admission compared to baseline.
en-copyright=
kn-copyright=

en-aut-name=HongoTakashi
en-aut-sei=Hongo
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YumotoTetsuya
en-aut-sei=Yumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=InabaMototaka
en-aut-sei=Inaba
en-aut-mei=Mototaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TaitoShunsuke
en-aut-sei=Taito
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=the LIFE Study Investigators
en-aut-sei=the LIFE Study Investigators
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Okayama University Graduate School of Medicine, Dentistry,  and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Okayama University Graduate School of Medicine, Dentistry,  and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Okayama University Graduate School of Medicine, Dentistry,  and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Clinical Practice and Support, Hiroshima University Hospital
kn-affil=

affil-num=5
en-affil=Department of Epidemiology, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Okayama University Graduate School of Medicine, Dentistry,  and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Okayama University Graduate School of Medicine, Dentistry,  and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Okayama University Graduate School of Medicine, Dentistry,  and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=ADL
kn-keyword=ADL
en-keyword=Clinical frailty scale
kn-keyword=Clinical frailty scale
en-keyword=Critical illness
kn-keyword=Critical illness
en-keyword=Emergency department
kn-keyword=Emergency department
en-keyword=Intensive care
kn-keyword=Intensive care
en-keyword=QOL
kn-keyword=QOL
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=1161
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240209
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Enhancement of Outdoor Location-Based Augmented Reality Anchor Precision through VSLAM and Google Street View
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Outdoor Location-Based Augmented Reality (LAR) applications require precise positioning for seamless integrations of virtual content into immersive experiences. However, common solutions in outdoor LAR applications rely on traditional smartphone sensor fusion methods, such as the Global Positioning System (GPS) and compasses, which often lack the accuracy needed for precise AR content alignments. In this paper, we introduce an innovative approach to enhance LAR anchor precision in outdoor environments. We leveraged Visual Simultaneous Localization and Mapping (VSLAM) technology, in combination with innovative cloud-based methodologies, and harnessed the extensive visual reference database of Google Street View (GSV), to address the accuracy limitation problems. For the evaluation, 10 Point of Interest (POI) locations were used as anchor point coordinates in the experiments. We compared the accuracies between our approach and the common sensor fusion LAR solution comprehensively involving accuracy benchmarking and running load performance testing. The results demonstrate substantial enhancements in overall positioning accuracies compared to conventional GPS-based approaches for aligning AR anchor content in the real world.
en-copyright=
kn-copyright=

en-aut-name=BrataKomang Candra
en-aut-sei=Brata
en-aut-mei=Komang Candra
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FunabikiNobuo
en-aut-sei=Funabiki
en-aut-mei=Nobuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=PandumanYohanes Yohanie Fridelin
en-aut-sei=Panduman
en-aut-mei=Yohanes Yohanie Fridelin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FajriantiEvianita Dewi
en-aut-sei=Fajrianti
en-aut-mei=Evianita Dewi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=location-based
kn-keyword=location-based
en-keyword=augmented reality
kn-keyword=augmented reality
en-keyword=SLAM
kn-keyword=SLAM
en-keyword=cloud-based matching
kn-keyword=cloud-based matching
en-keyword=Android
kn-keyword=Android
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=548
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Ultrathin Platinum Film Hydrogen Sensors with a Twin-T Type Notch Filter Circuit
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In recent years, hydrogen energy has garnered attention as a potential solution for mitigating greenhouse gas emissions. However, concerns regarding the inherent risk of hydrogen gas leakage and potential explosions have necessitated the development of advanced sensors. Within our research group, we have innovated an ultrathin platinum (Pt) film hydrogen sensor that gauges resistance changes in Pt thin films when exposed to hydrogen gas. Notably, the sensitivity of each sensor is contingent upon the thickness of the Pt film. To address the challenge of detecting hydrogen using multiple sensors, we integrated the ultrathin Pt film as a resistance element within a twin-T type notch filter. This filter exhibits a distinctive reduction in output signals at a specific frequency. The frequency properties of the notch filter dynamically alter with changes in the resistance of the Pt film induced by hydrogen exposure. Consequently, the ultrathin Pt film hydrogen sensor monitors output signal variations around the notch frequency, responding to shifts in frequency properties. This innovative approach enables the electrical control of sensor sensitivity by adjusting the operating frequency in proximity to the notch frequency. Additionally, the simultaneous detection of hydrogen by multiple sensors was successfully achieved by interconnecting sensors with distinct notch frequencies in series.
en-copyright=
kn-copyright=

en-aut-name=WakabayashiShoki
en-aut-sei=Wakabayashi
en-aut-mei=Shoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhYuki
en-aut-sei=Oh
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakayamaHaruhito
en-aut-sei=Nakayama
en-aut-mei=Haruhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WangJin
en-aut-sei=Wang
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KiwaToshihiko
en-aut-sei=Kiwa
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=hydrogen sensor
kn-keyword=hydrogen sensor
en-keyword=ultrathin film
kn-keyword=ultrathin film
en-keyword=twin-T
kn-keyword=twin-T
en-keyword=notch filter
kn-keyword=notch filter
en-keyword=platinum
kn-keyword=platinum
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=55
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Influence of the coronavirus disease 2019 pandemic on the post-graduate career paths of medical students: a cross-sectional study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background The World Health Organization first declared the coronavirus disease 2019 (COVID-19) pandemic in March 2020 and announced the end of the emergency in May 2023. Additionally, the COVID-19 pandemic significantly impacted individuals globally, including medical students. Although the COVID-19 pandemic increased online education, it restricted clinical training, extracurricular activities, and interprovincial travel. Therefore, this study aimed to examine whether the COVID-19 pandemic influenced the choice of training hospitals and career paths among 3rd- to 6th-year medical students in Japan.<br>
Methods We developed a questionnaire comprising 21 multiple-choice and 1 open-ended questions, which was administered anonymously via online platforms. The survey targeted Japanese medical students to obtain insights into their preferences for training hospitals and career paths during the COVID-19 pandemic. Participants included 4th- to 6th-year medical students from 51 medical schools in Japan. The survey was conducted through student networks from 8 February 2022 to 20 March 2022.<br>
Results Overall, 507 medical students participated in the survey, with representation from various academic years as follows: 102 (20.1%), 134 (26.4%), 121 (23.9%), and 150 (29.6%) students from the 3rd, 4th, 5th, and 6th year, respectively. Of these, 338 (66.6%) students reported that the COVID-19 pandemic had influenced their choice of training hospitals. The degree of the influence varied based on the university region and the student year. However, most of the students (473, 93.3%) did not change their course for clinical, basic research, or administrative pathways due to the COVID-19 pandemic. Among the clinically oriented students, 391 (77.2%) did not change their preferred speciality.<br>
Conclusions The COVID-19 pandemic influenced medical students' choice of training hospitals. Although many students believed that the pandemic would not change their career choices, our results indicate a potential subconscious trend to avoid internal medicine, which is the speciality most directly involved in treating patients with COVID-19.
en-copyright=
kn-copyright=

en-aut-name=NishimuraAyumu
en-aut-sei=Nishimura
en-aut-mei=Ayumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyoshiTomoko
en-aut-sei=Miyoshi
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsukawaAkihiro
en-aut-sei=Matsukawa
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Okayama University Medical School Faculty of Medicine
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Graduate School of Medicine,  Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Graduate School of Medicine,  Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Pathology and Experimental Medicine, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=COVID-19 pandemic
kn-keyword=COVID-19 pandemic
en-keyword=Medical students
kn-keyword=Medical students
en-keyword=Career path
kn-keyword=Career path
en-keyword=Training hospitals
kn-keyword=Training hospitals
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=18
article-no=
start-page=14128
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230915
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Advanced Techniques Using In Vivo Electroporation to Study the Molecular Mechanisms of Cerebral Development Disorders
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The mammalian cerebral cortex undergoes a strictly regulated developmental process. Detailed in situ visualizations, imaging of these dynamic processes, and in vivo functional gene studies significantly enhance our understanding of brain development and related disorders. This review introduces basic techniques and recent advancements in in vivo electroporation for investigating the molecular mechanisms underlying cerebral diseases. In utero electroporation (IUE) is extensively used to visualize and modify these processes, including the forced expression of pathological mutants in human diseases; thus, this method can be used to establish animal disease models. The advent of advanced techniques, such as genome editing, including de novo knockout, knock-in, epigenetic editing, and spatiotemporal gene regulation, has further expanded our list of investigative tools. These tools include the iON expression switch for the precise control of timing and copy numbers of exogenous genes and TEMPO for investigating the temporal effects of genes. We also introduce the iGONAD method, an improved genome editing via oviductal nucleic acid delivery approach, as a novel genome-editing technique that has accelerated brain development exploration. These advanced in vivo electroporation methods are expected to provide valuable insights into pathological conditions associated with human brain disorders.
en-copyright=
kn-copyright=

en-aut-name=YangChen
en-aut-sei=Yang
en-aut-mei=Chen
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShitamukaiAtsunori
en-aut-sei=Shitamukai
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YangShucai
en-aut-sei=Yang
en-aut-mei=Shucai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawaguchiAyano
en-aut-sei=Kawaguchi
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Human Morphology, Okayama University Graduate School of Medicine, Density and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Human Morphology, Okayama University Graduate School of Medicine, Density and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Human Anatomy and Histology and Embryology, School of Basic Medicine, Harbin Medical University
kn-affil=

affil-num=4
en-affil=Department of Human Morphology, Okayama University Graduate School of Medicine, Density and Pharmaceutical Sciences
kn-affil=
en-keyword=in vivo electroporation
kn-keyword=in vivo electroporation
en-keyword=in utero electroporation
kn-keyword=in utero electroporation
en-keyword=genome editing
kn-keyword=genome editing
en-keyword=IUE
kn-keyword=IUE
en-keyword=iON
kn-keyword=iON
en-keyword=TEMPO
kn-keyword=TEMPO
en-keyword=iGONAD
kn-keyword=iGONAD
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=24
article-no=
start-page=17294
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20231209
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Positive Regulation of S-Adenosylmethionine on Chondrocytic Differentiation via Stimulation of Polyamine Production and the Gene Expression of Chondrogenic Differentiation Factors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=S-adenosylmethionine (SAM) is considered to be a useful therapeutic agent for degenerative cartilage diseases, although its mechanism is not clear. We previously found that polyamines stimulate the expression of differentiated phenotype of chondrocytes. We also found that the cellular communication network factor 2 (CCN2) played a huge role in the proliferation and differentiation of chondrocytes. Therefore, we hypothesized that polyamines and CCN2 could be involved in the chondroprotective action of SAM. In this study, we initially found that exogenous SAM enhanced proteoglycan production but not cell proliferation in human chondrocyte-like cell line-2/8 (HCS-2/8) cells. Moreover, SAM enhanced gene expression of cartilage-specific matrix (aggrecan and type II collagen), Sry-Box transcription factor 9 (SOX9), CCN2, and chondroitin sulfate biosynthetic enzymes. The blockade of the methionine adenosyltransferase 2A (MAT2A) enzyme catalyzing intracellular SAM biosynthesis restrained the effect of SAM on chondrocytes. The polyamine level in chondrocytes was higher in SAM-treated culture than control culture. Additionally, Alcian blue staining and RT-qPCR indicated that the effects of SAM on the production and gene expression of aggrecan were reduced by the inhibition of polyamine synthesis. These results suggest that the stimulation of polyamine synthesis and gene expression of chondrogenic differentiation factors, such as CCN2, account for the mechanism underlying the action of SAM on chondrocytes.
en-copyright=
kn-copyright=

en-aut-name=HoangLoc Dinh
en-aut-sei=Hoang
en-aut-mei=Loc Dinh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AoyamaEriko
en-aut-sei=Aoyama
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HiasaMiki
en-aut-sei=Hiasa
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OmoteHiroshi
en-aut-sei=Omote
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KubotaSatoshi
en-aut-sei=Kubota
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KubokiTakuo
en-aut-sei=Kuboki
en-aut-mei=Takuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakigawaMasaharu
en-aut-sei=Takigawa
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Advanced Research Center for Oral and Craniofacial Sciences (ARCOCS), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Advanced Research Center for Oral and Craniofacial Sciences (ARCOCS), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Advanced Research Center for Oral and Craniofacial Sciences (ARCOCS), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=S-adenosylmethionine
kn-keyword=S-adenosylmethionine
en-keyword=chondrocyte differentiation
kn-keyword=chondrocyte differentiation
en-keyword=CCN2
kn-keyword=CCN2
en-keyword=polyamine
kn-keyword=polyamine
en-keyword=ODC
kn-keyword=ODC
en-keyword=gene expression
kn-keyword=gene expression
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=20
article-no=
start-page=15450
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20231022
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Roles of Oxidative Injury and Nitric Oxide System Derangements in Kawasaki Disease Pathogenesis: A Systematic Review
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Kawasaki disease (KD) is an acute febrile vasculitis that occurs mostly in children younger than five years. KD involves multiple intricately connected inflammatory reactions activated by a cytokine cascade. Despite therapeutic advances, coronary artery damage may develop in some patients, who will be at risk of clinical cardiovascular events and even sudden death. The etiology of KD remains unclear; however, it may involve both genetic and environmental factors leading to aberrant inflammatory responses. Given the young age of onset, prenatal or perinatal exposure may be etiologically relevant. Multisystem inflammatory syndrome in children, a post-infectious hyper-inflammatory disorder associated with severe acute respiratory syndrome coronavirus 2, has features that overlap with those of KD. Available evidence indicates that vascular endothelial dysfunction is a critical step in the sequence of events leading to the development of cardiovascular lesions in KD. Oxidative stress and the dysregulation of the nitric oxide (NO) system contribute to the pathogenesis of inflammatory responses related to this disease. This review provides current evidence and concepts highlighting the adverse effects of oxidative injury and NO system derangements on the initiation and progression of KD and potential therapeutic strategies for cardiovascular pathologies in affected children.
en-copyright=
kn-copyright=

en-aut-name=TsugeMitsuru
en-aut-sei=Tsuge
en-aut-mei=Mitsuru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UdaKazuhiro
en-aut-sei=Uda
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=EitokuTakahiro
en-aut-sei=Eitoku
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsumotoNaomi
en-aut-sei=Matsumoto
en-aut-mei=Naomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TsukaharaHirokazu
en-aut-sei=Tsukahara
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Pediatrics, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Epidemiology, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Epidemiology, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=biomarker
kn-keyword=biomarker
en-keyword=coronary artery lesions
kn-keyword=coronary artery lesions
en-keyword=Kawasaki disease
kn-keyword=Kawasaki disease
en-keyword=multisystem inflammatory syndrome in children
kn-keyword=multisystem inflammatory syndrome in children
en-keyword=nitric oxide
kn-keyword=nitric oxide
en-keyword=nitrosative stress
kn-keyword=nitrosative stress
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=systemic inflammation
kn-keyword=systemic inflammation
en-keyword=vascular endothelial dysfunction
kn-keyword=vascular endothelial dysfunction
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=80
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20231004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Radiation in an emergency situation: attempting to respect the patient's beliefs as reported by a minor
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background　Each individual's unique health-related beliefs can greatly impact the patient-clinician relationship. When there is a conflict between the patient's preferences and recommended medical care, it can create a serious ethical dilemma, especially in an emergency setting, and dramatically alter this important relationship.<br>
Case presentation　A 56-year-old man, who remained comatose after out-of-hospital cardiac arrest, was rushed to our hospital. The patient was scheduled for emergency coronary angiography when his adolescent daughter reported that she and her father held sincere beliefs against radiation exposure. We were concerned that she did not fully understand the potential consequences if her father did not receive the recommended treatment. A physician provided her with in depth information regarding the risks and benefits of the treatment. While we did not want to disregard her statement, we opted to save the patient's life due to concerns about the validity of her report.<br>
Conclusions　Variations in beliefs regarding medical care force clinicians to incorporate patient beliefs into medical practice. However, an emergency may require a completely different approach. When faced with a patient in a life-threatening condition and unconscious, we should take action to prioritize saving their life, unless we are highly certain about the validity of their advance directives.
en-copyright=
kn-copyright=

en-aut-name=YumotoTetsuya
en-aut-sei=Yumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HongoTakashi
en-aut-sei=Hongo
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KoideYasuhiro
en-aut-sei=Koide
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ObaraTakafumi
en-aut-sei=Obara
en-aut-mei=Takafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsukaharaKohei
en-aut-sei=Tsukahara
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty  of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Emergency service
kn-keyword=Emergency service
en-keyword=Informed consent
kn-keyword=Informed consent
en-keyword=Radiation
kn-keyword=Radiation
en-keyword=Treatment refusal
kn-keyword=Treatment refusal
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=727
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Increased quadriceps muscle strength after medial meniscus posterior root repair is associated with decreased medial meniscus extrusion progression
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background　This study aimed to assess quadriceps muscle strength after medial meniscus (MM) posterior root repair and determine its relationship with clinical scores and MM extrusion (MME). <br>
Methods　Thirty patients who underwent pullout repair for MM posterior root tear and were evaluated for quadriceps muscle strength preoperatively and at 1 year postoperatively were included in this study. Quadriceps muscle strength was measured using the Locomo Scan-II instrument (ALCARE, Tokyo, Japan). MME and clinical scores (i.e., Knee Injury and Osteoarthritis Outcome Score [KOOS], International Knee Documentation Committee score, Lysholm score, Tegner score, and visual analog scale pain score) were evaluated preoperatively and at 1 year postoperatively, and second-look arthroscopy was performed at 1 year postoperatively. Wilcoxon ' s signed-rank test was used to compare each measure pre-and postoperatively. Pearson ' s correlation coefficient was used to assess the correlation with quadriceps muscle strength values. Multiple regression analysis was performed to identify factors associated with the change in MME (.MME). <br>
Results　Second-look arthroscopy confirmed continuity of the posterior root in all patients. The quadriceps muscle strength measured at 1 year postoperatively (355.1 +/- 116.2 N) indicated significant improvement relative to the quadriceps muscle strength measured preoperatively (271.9 +/- 97.4 N, p < 0.001). The MME at 1 year postoperatively (4.59 +/- 1.24 mm) had progressed significantly relative to the MME preoperatively (3.63 +/- 1.01 mm, p < 0.001). The clinical scores at 1 year postoperatively were improved significantly relative to the scores preoperatively (p < 0.001). The postoperative quadriceps muscle strength was correlated with.MME (correlation coefficient = -0.398, p = 0.030), and the change in quadriceps muscle strength was correlated with the KOOS-Quality of Life (correlation coefficient = 0.430, p = 0.018). Multiple regression analysis showed that the postoperative quadriceps muscle strength had a significant effect on.MME even when the body mass index and time from injury to surgery were included. <br>
Conclusions　After MM posterior root repair, patients with greater quadriceps muscle strength showed less MME progression. In addition, patients with greater improvement in quadriceps muscle strength had better clinical scores; therefore, continued rehabilitation aimed at improving quadriceps muscle strength after MM posterior root repair is recommended.
en-copyright=
kn-copyright=

en-aut-name=KawadaKoki
en-aut-sei=Kawada
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FukubaMikao
en-aut-sei=Fukuba
en-aut-mei=Mikao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TamuraMasanori
en-aut-sei=Tamura
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HigashiharaNaohiro
en-aut-sei=Higashihara
en-aut-mei=Naohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkazakiYuki
en-aut-sei=Okazaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YokoyamaYusuke
en-aut-sei=Yokoyama
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KatayamaYoshimi
en-aut-sei=Katayama
en-aut-mei=Yoshimi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HamadaMasanori
en-aut-sei=Hamada
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School  of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Clinical score
kn-keyword=Clinical score
en-keyword=Medial meniscus
kn-keyword=Medial meniscus
en-keyword=Medial meniscus extrusion
kn-keyword=Medial meniscus extrusion
en-keyword=Muscle strength
kn-keyword=Muscle strength
en-keyword=Posterior root tear
kn-keyword=Posterior root tear
en-keyword=Quadriceps
kn-keyword=Quadriceps
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=5
article-no=
start-page=382
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220913
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Investigation of bone invasion and underlying mechanisms of oral cancer using a cell line‑derived xenograft model
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The cancer stroma regulates bone invasion in oral squamous cell carcinoma (OSCC). However, data on normal stroma are limited. In the present study, the effects of gingival and periodontal ligament tissue‑derived stromal cells (G‑SCs and P‑SCs, respectively) and human dermal fibroblasts (HDFs) on bone resorption and osteoclast activation were assessed using hematoxylin and eosin and tartrate‑resistant acid phosphatase staining in a cell line‑derived xenograft model. The results demonstrated that G‑SCs promoted bone invasion and osteoclast activation and inhibited osteoclast proliferation following crosstalk with the human OSCC HSC‑3 cell line, whereas P‑SCs inhibited bone resorption and promoted osteoclast proliferation in vitro but had a minimal effect on osteoclast activation both in vitro and in vivo following crosstalk with HSC‑3 cells. Furthermore, the effects of G‑SCs, P‑SCs and HDFs on protein expression levels of matrix metalloproteinase (MMP)‑9, membrane type 1 MMP (MT1‑MMP), Snail, parathyroid hormone‑related peptide (PTHrP) and receptor activator of NF‑κB ligand (RANKL) in HSC‑3 cells in OSCC bone invasion regions were assessed using immunohistochemistry. The results demonstrated that G‑SCs had a more prominent effect on the expression of MMP‑9, MT1‑MMP, Snail, PTHrP, and RANKL, whereas P‑SCs only promoted RANKL and PTHrP expression and exerted a minimal effect on MMP‑9, MT1‑MMP and Snail expression. The potential genes underlying the differential effects of G‑SCs and P‑SCs on bone invasion in OSCC were evaluated using a microarray, which indicated that cyclin‑dependent kinase 1, insulin, aurora kinase A, cyclin B1 and DNA topoisomerase II alpha underlaid these differential effects. Therefore, these results demonstrated that G‑SCs promoted bone invasion in OSCC by activating osteoclasts on the bone surface, whereas P‑SCs exerted an inhibitory effect. These findings could indicate a potential regulatory mechanism for bone invasion in OSCC.
en-copyright=
kn-copyright=

en-aut-name=ShanQiusheng
en-aut-sei=Shan
en-aut-mei=Qiusheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakabatakeKiyofumi
en-aut-sei=Takabatake
en-aut-mei=Kiyofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OmoriHaruka
en-aut-sei=Omori
en-aut-mei=Haruka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OoMay Wathone
en-aut-sei=Oo
en-aut-mei=May Wathone
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SukegawaShintaro
en-aut-sei=Sukegawa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=FujiiMasae
en-aut-sei=Fujii
en-aut-mei=Masae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=InadaYasunori
en-aut-sei=Inada
en-aut-mei=Yasunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SanoSho
en-aut-sei=Sano
en-aut-mei=Sho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NakanoKeisuke
en-aut-sei=Nakano
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=oral squamous cell carcinoma
kn-keyword=oral squamous cell carcinoma
en-keyword=bone invasion
kn-keyword=bone invasion
en-keyword=gingival ligament tissue‑derived stromal cell
kn-keyword=gingival ligament tissue‑derived stromal cell
en-keyword=periodontal ligament tissue‑derived stromal cell
kn-keyword=periodontal ligament tissue‑derived stromal cell
en-keyword=xenograft model
kn-keyword=xenograft model
en-keyword=microarray
kn-keyword=microarray
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=18
article-no=
start-page=13692
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230905
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Germinal Origin of Salivary and Lacrimal Glands and the Contributions of Neural Crest Cell-Derived Epithelium to Tissue Regeneration
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The vertebrate body comprises four distinct cell populations: cells derived from (1) ectoderm, (2) mesoderm, (3) endoderm, and (4) neural crest cells, often referred to as the fourth germ layer. Neural crest cells arise when the neural plate edges fuse to form a neural tube, which eventually develops into the brain and spinal cord. To date, the embryonic origin of exocrine glands located in the head and neck remains under debate. In this study, transgenic TRiCK mice were used to investigate the germinal origin of the salivary and lacrimal glands. TRiCK mice express fluorescent proteins under the regulatory control of Sox1, T/Brachyury, and Sox17 gene expressions. These genes are representative marker genes for neuroectoderm (Sox1), mesoderm (T), and endoderm (Sox17). Using this approach, the cellular lineages of the salivary and lacrimal glands were examined. We demonstrate that the salivary and lacrimal glands contain cells derived from all three germ layers. Notably, a subset of Sox1-driven fluorescent cells differentiated into epithelial cells, implying their neural crest origin. Also, these Sox1-driven fluorescent cells expressed high levels of stem cell markers. These cells were particularly pronounced in duct ligation and wound damage models, suggesting the involvement of neural crest-derived epithelial cells in regenerative processes following tissue injury. This study provides compelling evidence clarifying the germinal origin of exocrine glands and the contribution of neural crest-derived cells within the glandular epithelium to the regenerative response following tissue damage.
en-copyright=
kn-copyright=

en-aut-name=Ono-MinagiHitomi
en-aut-sei=Ono-Minagi
en-aut-mei=Hitomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NohnoTsutomu
en-aut-sei=Nohno
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SerizawaTakashi
en-aut-sei=Serizawa
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UsamiYu
en-aut-sei=Usami
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SakaiTakayoshi
en-aut-sei=Sakai
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkanoHideyuki
en-aut-sei=Okano
en-aut-mei=Hideyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OhuchiHideyo
en-aut-sei=Ohuchi
en-aut-mei=Hideyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cytology and Histology, Okayama University Medical School
kn-affil=

affil-num=3
en-affil=Department of Physiology, Keio University School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Pathology, Osaka University Graduate School of Dentistry
kn-affil=

affil-num=5
en-affil=Department of Rehabilitation for Orofacial Disorders, Osaka University Graduate School of Dentistry
kn-affil=

affil-num=6
en-affil=Department of Physiology, Keio University School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Cytology and Histology, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=salivary and lacrimal glands
kn-keyword=salivary and lacrimal glands
en-keyword=development
kn-keyword=development
en-keyword=three germ layers
kn-keyword=three germ layers
en-keyword=neural crest
kn-keyword=neural crest
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=345
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220817
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of bacterium in the malignant wounds of soft tissue sarcoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Malignant wounds (MWs) are rare skin lesions, which accompany ulceration, necrosis and infection caused by infiltration or damage by malignant tumor. The present study aimed to investigate the bacterial etiology implicated in MW in soft tissue sarcoma (STS), and the effectiveness of culture‑guided perioperative antibacterial administration. A retrospective evaluation was conducted on medical records of patients who presented with MW between 2006 and 2020. A total of seven patients were included in the present study, in whom all tumors were relatively large (>5 cm) and high‑grade. Subsequently, five patients underwent limb‑sparing surgery, and three patients had distant metastases with a 5‑year overall survival of 71%. Preoperative microbiological sampling from the wound identified 11 different bacterial strains in five patients. The infections were polymicrobial with an average of 2.6 strains isolated per patient (1 aerobic, 1.6 anaerobic bacteria). They were predominantly methicillin‑sensitive Staphylococcus aureus. Patients with MWs from STS reported symptoms, including bleeding (71%), exudation (71%) and malodorous wound (43%) at the initial presentation; these completely resolved after surgery. All but one patient reported pain at the MW site with an average numeric rating scale of 4.4 at presentation that decreased to 1.4 (P=0.14) and 0.6 (P=0.04) one and two weeks after surgery, respectively. The patients had elevated C‑reactive protein (71%), anemia (57%), low albumin (86%) and renal/liver dysfunction (14‑29%). One patient was diagnosed with sepsis. Surgical resection afforded symptomatic relief and resolution of abnormal laboratory values. Although selected antibiotics were administered in four patients based on the preoperative antibiotic sensitivity test, surgical site infection (SSI) occurred in three patients. Therefore, the effectiveness of the selected antibiotics based on the results of the preoperative culture in preventing SSI needs to be investigated in the future. In conclusion, physicians should keep in mind that although surgical resection can improve the symptoms and abnormal values in laboratory examination form MW, it is accompanied with a high rate of SSI and poor prognosis.
en-copyright=
kn-copyright=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KatayamaHaruyoshi
en-aut-sei=Katayama
en-aut-mei=Haruyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ItanoTakuto
en-aut-sei=Itano
en-aut-mei=Takuto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KunisadaToshiyuki
en-aut-sei=Kunisada
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=
en-keyword=malignant wounds
kn-keyword=malignant wounds
en-keyword=soft tissue sarcoma
kn-keyword=soft tissue sarcoma
en-keyword=microbiological analysis
kn-keyword=microbiological analysis
en-keyword=surgical site infection
kn-keyword=surgical site infection
en-keyword=prognosis
kn-keyword=prognosis
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=319
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220719
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Clinicopathological and histological analysis of secondary malignant giant cell tumors of bone without radiotherapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Giant cell tumor of bone (GCTB) is an intermediate bone tumor that rarely undergoes malignant transformation. Secondary malignant GCTB (SMGCTB) is defined as a lesion in which high‑grade sarcoma occurs at the site of previously treated GCTB. The present study retrospectively reviewed the medical records of patients with GCTB treated at Okayama University Hospital between April 1986 and April 2020. The clinicopathological and histological features of patients with SMGCTB without prior radiotherapy were investigated. A total of three patients (4%) with SMGCTB were detected, and the tumor sites were the distal ulna, distal femur and sacrum. Two of the patients had been treated with curettage and bone graft, and one had been treated with denosumab. In all cases, the lesions were made up of two components, the conventional GCTB component and the malignant component. The Ki67 labeling index was higher in the malignant components of SMGCTB and metastatic lesions compared with that in primary and recurrent conventional GCTB, or the conventional GCTB component of SMGCTB. Moreover, p53 expression was higher in these same components in patients who underwent curettage and bone grafting; however, there was no difference in the patient that received denosumab treatment. In this patient, clinical cancer genomic profiling revealed loss of CDKN2A, CDKN2B and MTAP expression. All three patients developed distant metastasis. The patients with SMGCTB in the ulna and femur died 13 and 54 months after detection of malignant transformation, respectively. The patient with SMGCTB in the sacrum received carbon‑ion radiotherapy to the sacrum and pazopanib; the treatment was effective and the patient was alive at the last follow‑up 3 years later. In conclusion, p53 may be associated with malignant transformation in GCTB. Future studies should investigate the association of between denosumab treatment and malignant transformation, as well as molecular targeted therapy to improve the clinical outcomes of SMGCTB.
en-copyright=
kn-copyright=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KunisadaToshiyuki
en-aut-sei=Kunisada
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=InoueHirofumi
en-aut-sei=Inoue
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FutagawaMashu
en-aut-sei=Futagawa
en-aut-mei=Mashu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KatayamaHaruyoshi
en-aut-sei=Katayama
en-aut-mei=Haruyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ItanoTakuto
en-aut-sei=Itano
en-aut-mei=Takuto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Pathology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Clinical Genomic Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=
en-keyword=giant cell tumor of bone
kn-keyword=giant cell tumor of bone
en-keyword=malignant transformation
kn-keyword=malignant transformation
en-keyword=p53
kn-keyword=p53
en-keyword=denosumab
kn-keyword=denosumab
en-keyword=molecular targeted therapy
kn-keyword=molecular targeted therapy
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=8
article-no=
start-page=1429
end-page=1438
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220518
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Rationale, design and baseline characteristics of the effect of canagliflozin in patients with type 2 diabetes and microalbuminuria in the Japanese population: The CANPIONE study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Aim: To evaluate the effect of canagliflozin, a sodium-glucose co-transporter-2 (SGLT2) inhibitor, on albuminuria and the decline of estimated glomerular filtration rate (eGFR) in participants with type 2 diabetes and microalbuminuria.<br>
Methods: The CANPIONE study is a multicentre, randomized, parallel-group and open-labelled study consisting of a unique 24-week preintervention period, during which the rate of eGFR decline before intervention is estimated, followed by a 52-week intervention and a 4-week washout period. Participants with a geometric mean urinary albumin-to-creatinine ratio (UACR) of 50 and higher and less than 300 mg/g in two consecutive first-morning voids at two different time points, and an eGFR of 45 ml/min/1.73m2 or higher, are randomly assigned to receive canagliflozin 100 mg daily or to continue guideline-recommended treatment, except for SGLT2 inhibitors. The first primary outcome is the change in UACR, and the second primary outcome is the change in eGFR slope.<br>
Results: A total of 258 participants were screened and 98 were randomized at 21 sites in Japan from August 2018 to May 2021. The mean baseline age was 61.4 years and 25.8% were female. The mean HbA1c was 7.9%, mean eGFR was 74.1 ml/min/1.73m2 and median UACR was 104.2 mg/g.<br>
Conclusions: The CANPIONE study will determine whether the SGLT2 inhibitor canagliflozin can reduce albuminuria and slow eGFR decline in participants with type 2 diabetes and microalbuminuria.
en-copyright=
kn-copyright=

en-aut-name=MiyamotoSatoshi
en-aut-sei=Miyamoto
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HeerspinkHiddo J. L.
en-aut-sei=Heerspink
en-aut-mei=Hiddo J. L.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=de ZeeuwDick
en-aut-sei=de Zeeuw
en-aut-mei=Dick
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ToyodaMasao
en-aut-sei=Toyoda
en-aut-mei=Masao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SuzukiDaisuke
en-aut-sei=Suzuki
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HatanakaTakashi
en-aut-sei=Hatanaka
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakamuraTohru
en-aut-sei=Nakamura
en-aut-mei=Tohru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KameiShinji
en-aut-sei=Kamei
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MuraoSatoshi
en-aut-sei=Murao
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HidaKazuyuki
en-aut-sei=Hida
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AndoShinichiro
en-aut-sei=Ando
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=AkaiHiroaki
en-aut-sei=Akai
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TakahashiYasushi
en-aut-sei=Takahashi
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KoyaDaisuke
en-aut-sei=Koya
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KitadaMunehiro
en-aut-sei=Kitada
en-aut-mei=Munehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=SuganoHisashi
en-aut-sei=Sugano
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=NunoueTomokazu
en-aut-sei=Nunoue
en-aut-mei=Tomokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=NakamuraAkihiko
en-aut-sei=Nakamura
en-aut-mei=Akihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=SasakiMotofumi
en-aut-sei=Sasaki
en-aut-mei=Motofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=NakatouTatsuaki
en-aut-sei=Nakatou
en-aut-mei=Tatsuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=FujimotoKei
en-aut-sei=Fujimoto
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=KawanamiDaiji
en-aut-sei=Kawanami
en-aut-mei=Daiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=WadaTakashi
en-aut-sei=Wada
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

en-aut-name=MiyatakeNobuyuki
en-aut-sei=Miyatake
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=24
ORCID=

en-aut-name=YoshidaMichihiro
en-aut-sei=Yoshida
en-aut-mei=Michihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=25
ORCID=

en-aut-name=ShikataKenichi
en-aut-sei=Shikata
en-aut-mei=Kenichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=26
ORCID=

en-aut-name=the CANPIONE study Investigators
en-aut-sei=the CANPIONE study Investigators
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=27
ORCID=

affil-num=1
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen
kn-affil=

affil-num=3
en-affil=Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen
kn-affil=

affil-num=4
en-affil=Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine
kn-affil=

affil-num=5
en-affil=Suzuki Diadetes Clinic
kn-affil=

affil-num=6
en-affil=Department of Diabetes and Endocrinology, National Hospital Organization Fukuyama Medical Center
kn-affil=

affil-num=7
en-affil=Diabetes Internal Medicine, Sumitomo Besshi Hospital
kn-affil=

affil-num=8
en-affil=Department of Diabetic Medicine, Kurashiki Central Hospital
kn-affil=

affil-num=9
en-affil=Department of Diabetes and Endocrinology, Takamatsu Hospital
kn-affil=

affil-num=10
en-affil=Department of Diabetology and Metabolism, National Hospital Organization Okayama Medical Center
kn-affil=

affil-num=11
en-affil=Department of Internal Medicine Diabetic Center, Okayama City Hospital
kn-affil=

affil-num=12
en-affil=Division of Diabetes and Metabolism, Faculty of Medicine, Tohoku Medical and Pharmaceutical University
kn-affil=

affil-num=13
en-affil=Department of Diabetes, Ochiai General Hospital
kn-affil=

affil-num=14
en-affil=Department of Diabetology and Endocrinology, Kanazawa Medical University
kn-affil=

affil-num=15
en-affil=Department of Diabetology and Endocrinology, Kanazawa Medical University
kn-affil=

affil-num=16
en-affil=Department of Diabetes and Endocrinology, Kochi Health Sciences Center
kn-affil=

affil-num=17
en-affil=Nunoue Clinic
kn-affil=

affil-num=18
en-affil=Internal Medicine, Osafune Clinic, Setouchi
kn-affil=

affil-num=19
en-affil=Department of Diabetes and Endocrinology, Matsue City Hospital
kn-affil=

affil-num=20
en-affil=Diabetes Center, Okayama Saiseikai General Hospital
kn-affil=

affil-num=21
en-affil=Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University Kashiwa Hospital
kn-affil=

affil-num=22
en-affil=Department of Endocrinology and Diabetes Mellitus, Fukuoka University School of Medicine
kn-affil=

affil-num=23
en-affil=Department of Nephrology and Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University
kn-affil=

affil-num=24
en-affil=Department of Hygiene, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=25
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=26
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=27
en-affil=
kn-affil=
en-keyword=canagliflozin
kn-keyword=canagliflozin
en-keyword=CANPIONE study
kn-keyword=CANPIONE study
en-keyword=diabetic kidney disease
kn-keyword=diabetic kidney disease
en-keyword=eGFR slope
kn-keyword=eGFR slope
en-keyword=SGLT2 inhibitor
kn-keyword=SGLT2 inhibitor
en-keyword=urinary albumin-to-creatinine ratio
kn-keyword=urinary albumin-to-creatinine ratio
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=16
article-no=
start-page=12559
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230808
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Interaction of Orexin and Bone Morphogenetic Proteins in Steroidogenesis by Human Adrenocortical Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Orexins are neuropeptides that play important roles in sleep-wake regulation and food intake in the central nervous system, but their receptors are also expressed in peripheral tissues, including the endocrine system. In the present study, we investigated the functions of orexin in adrenal steroidogenesis using human adrenocortical H295R cells by focusing on its interaction with adrenocortical bone morphogenetic proteins (BMPs) that induce adrenocortical steroidogenesis. Treatment with orexin A increased the mRNA levels of steroidogenic enzymes including StAR, CYP11B2, CYP17, and HSD3B1, and these effects of orexin A were further enhanced in the presence of forskolin. Interestingly, orexin A treatment suppressed the BMP-receptor signaling detected by Smad1/5/9 phosphorylation and Id-1 expression through upregulation of inhibitory Smad7. Orexin A also suppressed endogenous BMP-6 expression but increased the expression of the type-II receptor of ActRII in H295R cells. Moreover, treatment with BMP-6 downregulated the mRNA level of OX1R, but not that of OX2R, expressed in H295R cells. In conclusion, the results indicate that both orexin and BMP-6 accelerate adrenocortical steroidogenesis in human adrenocortical cells; both pathways mutually inhibit each other, thereby leading to a fine-tuning of adrenocortical steroidogenesis.
en-copyright=
kn-copyright=

en-aut-name=SoejimaYoshiaki
en-aut-sei=Soejima
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IwataNahoko
en-aut-sei=Iwata
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishiokaRan
en-aut-sei=Nishioka
en-aut-mei=Ran
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HondaMako
en-aut-sei=Honda
en-aut-mei=Mako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakanoYasuhiro
en-aut-sei=Nakano
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamamotoKoichiro
en-aut-sei=Yamamoto
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SuyamaAtsuhito
en-aut-sei=Suyama
en-aut-mei=Atsuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=bone morphogenetic protein (BMP)
kn-keyword=bone morphogenetic protein (BMP)
en-keyword=orexin
kn-keyword=orexin
en-keyword=steroidogenesis and adrenal
kn-keyword=steroidogenesis and adrenal
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=14
article-no=
start-page=11768
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230721
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of Hydrophobic Cell-Penetrating Stapled Peptides as Drug Carriers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cell-penetrating peptides (CPPs) are widely used for the intracellular delivery of a variety of cargo molecules, including small molecules, peptides, nucleic acids, and proteins. Many cationic and amphiphilic CPPs have been developed; however, there have been few reports regarding hydrophobic CPPs. Herein, we have developed stapled hydrophobic CPPs based on the hydrophobic CPP, TP10, by introducing an aliphatic carbon side chain on the hydrophobic face of TP10. This side chain maintained the hydrophobicity of TP10 and enhanced the helicity and cell penetrating efficiency. We evaluated the preferred secondary structures, and the ability to deliver 5(6)-carboxyfluorescein (CF) as a model small molecule and plasmid DNA (pDNA) as a model nucleotide. The stapled peptide F-3 with CF, in which the stapling structure was introduced at Gly residues, formed a stable & alpha;-helical structure and the highest cell-membrane permeability via an endocytosis process. Meanwhile, peptide F-4 demonstrated remarkable stability when forming a complex with pDNA, making it the optimal choice for the efficient intracellular delivery of pDNA. The results showed that stapled hydrophobic CPPs were able to deliver small molecules and pDNA into cells, and that different stapling positions in hydrophobic CPPs can control the efficiency of the cargo delivery.
en-copyright=
kn-copyright=

en-aut-name=TsuchiyaKeisuke
en-aut-sei=Tsuchiya
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HorikoshiKanako
en-aut-sei=Horikoshi
en-aut-mei=Kanako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujitaMinami
en-aut-sei=Fujita
en-aut-mei=Minami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HiranoMotoharu
en-aut-sei=Hirano
en-aut-mei=Motoharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MiyamotoMaho
en-aut-sei=Miyamoto
en-aut-mei=Maho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YokooHidetomo
en-aut-sei=Yokoo
en-aut-mei=Hidetomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=DemizuYosuke
en-aut-sei=Demizu
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Division of Organic Chemistry, National Institute of Health Sciences
kn-affil=

affil-num=2
en-affil=Division of Organic Chemistry, National Institute of Health Sciences
kn-affil=

affil-num=3
en-affil=Division of Organic Chemistry, National Institute of Health Sciences
kn-affil=

affil-num=4
en-affil=Division of Organic Chemistry, National Institute of Health Sciences
kn-affil=

affil-num=5
en-affil=Division of Organic Chemistry, National Institute of Health Sciences
kn-affil=

affil-num=6
en-affil=Division of Organic Chemistry, National Institute of Health Sciences
kn-affil=

affil-num=7
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=cell-penetrating peptide
kn-keyword=cell-penetrating peptide
en-keyword=stapled peptide
kn-keyword=stapled peptide
en-keyword=hydrophobic peptide
kn-keyword=hydrophobic peptide
en-keyword=helical structure
kn-keyword=helical structure
en-keyword=plasmid DNA delivery
kn-keyword=plasmid DNA delivery
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=5
article-no=
start-page=317
end-page=319
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230725
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Task shifting of medical office works: A preliminary questionnaire survey for generalists
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To reduce physician burden, task shifting of clerical work from physicians to medical assistants is being promoted; however, it depends on hospitals. A questionnaire survey was conducted among 40 general physicians at Okayama University Hospital in December 2022 to investigate physicians' preferences toward task shifting. Compared to other tasks, most physicians thought that ordering examinations (14, 47%), replying to referral letters (19, 63%), and prescriptions (21, 70%) and medical record entries (22, 73%) should not be task shifted. Physicians' controversial opinions on task shifting maybe the reason behind the slow progress in task shifting.
en-copyright=
kn-copyright=

en-aut-name=OtsukaYuki
en-aut-sei=Otsuka
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SunadaNaruhiko
en-aut-sei=Sunada
en-aut-mei=Naruhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=burnout
kn-keyword=burnout
en-keyword=clerical work
kn-keyword=clerical work
en-keyword=medical assistant
kn-keyword=medical assistant
en-keyword=overwork
kn-keyword=overwork
en-keyword=task shift
kn-keyword=task shift
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=8
article-no=
start-page=7394
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230417
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Neuropilin 1 (NRP1) Positively Regulates Adipogenic Differentiation in C3H10T1/2 Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Neuropilin 1 (NRP1), a non-tyrosine kinase receptor for several ligands, is highly expressed in many kinds of mesenchymal stem cells (MSCs), but its function is poorly understood. In this study, we explored the roles of full-length NRP1 and glycosaminoglycan (GAG)-modifiable NRP1 in adipogenesis in C3H10T1/2 cells. The expression of full-length NRP1 and GAG-modifiable NRP1 increased during adipogenic differentiation in C3H10T1/2 cells. NRP1 knockdown repressed adipogenesis while decreasing the levels of Akt and ERK1/2 phosphorylation. Moreover, the scaffold protein JIP4 was involved in adipogenesis in C3H10T1/2 cells by interacting with NRP1. Furthermore, overexpression of non-GAG-modifiable NRP1 mutant (S612A) greatly promoted adipogenic differentiation, accompanied by upregulation of the phosphorylated Akt and ERK1/2. Taken together, these results indicate that NRP1 is a key regulator that promotes adipogenesis in C3H10T1/2 cells by interacting with JIP4 and activating the Akt and ERK1/2 pathway. Non-GAG-modifiable NRP1 mutant (S612A) accelerates the process of adipogenic differentiation, suggesting that GAG glycosylation is a negative post-translational modification of NRP1 in adipogenic differentiation.
en-copyright=
kn-copyright=

en-aut-name=YuYaqiong
en-aut-sei=Yu
en-aut-mei=Yaqiong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Uchida-FukuharaYoko
en-aut-sei=Uchida-Fukuhara
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WengYao
en-aut-sei=Weng
en-aut-mei=Yao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HeYuhan
en-aut-sei=He
en-aut-mei=Yuhan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IkegameMika
en-aut-sei=Ikegame
en-aut-mei=Mika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=WangZiyi
en-aut-sei=Wang
en-aut-mei=Ziyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YoshidaKaya
en-aut-sei=Yoshida
en-aut-mei=Kaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OkamuraHirohiko
en-aut-sei=Okamura
en-aut-mei=Hirohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=QiuLihong
en-aut-sei=Qiu
en-aut-mei=Lihong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases
kn-affil=

affil-num=2
en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases
kn-affil=

affil-num=5
en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral Healthcare Education, Institute of Biomedical Sciences, Tokushima University Graduate School
kn-affil=

affil-num=8
en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases
kn-affil=
en-keyword=neuropilin 1
kn-keyword=neuropilin 1
en-keyword=adipogenic differentiation
kn-keyword=adipogenic differentiation
en-keyword=mesenchymal stem cells
kn-keyword=mesenchymal stem cells
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=6
article-no=
start-page=5168
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Stress-Inducible SCAND Factors Suppress the Stress Response and Are Biomarkers for Enhanced Prognosis in Cancers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The cell stress response is an essential system present in every cell for responding and adapting to environmental stimulations. A major program for stress response is the heat shock factor (HSF)-heat shock protein (HSP) system that maintains proteostasis in cells and promotes cancer progression. However, less is known about how the cell stress response is regulated by alternative transcription factors. Here, we show that the SCAN domain (SCAND)-containing transcription factors (SCAN-TFs) are involved in repressing the stress response in cancer. SCAND1 and SCAND2 are SCAND-only proteins that can hetero-oligomerize with SCAN-zinc finger transcription factors, such as MZF1(ZSCAN6), for accessing DNA and transcriptionally co-repressing target genes. We found that heat stress induced the expression of SCAND1, SCAND2, and MZF1 bound to HSP90 gene promoter regions in prostate cancer cells. Moreover, heat stress switched the transcript variants' expression from long noncoding RNA (lncRNA-SCAND2P) to protein-coding mRNA of SCAND2, potentially by regulating alternative splicing. High expression of HSP90AA1 correlated with poorer prognoses in several cancer types, although SCAND1 and MZF1 blocked the heat shock responsiveness of HSP90AA1 in prostate cancer cells. Consistent with this, gene expression of SCAND2, SCAND1, and MZF1 was negatively correlated with HSP90 gene expression in prostate adenocarcinoma. By searching databases of patient-derived tumor samples, we found that MZF1 and SCAND2 RNA were more highly expressed in normal tissues than in tumor tissues in several cancer types. Of note, high RNA expression of SCAND2, SCAND1, and MZF1 correlated with enhanced prognoses of pancreatic cancer and head and neck cancers. Additionally, high expression of SCAND2 RNA was correlated with better prognoses of lung adenocarcinoma and sarcoma. These data suggest that the stress-inducible SCAN-TFs can function as a feedback system, suppressing excessive stress response and inhibiting cancers.
en-copyright=
kn-copyright=

en-aut-name=ShetaMona
en-aut-sei=Sheta
en-aut-mei=Mona
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YoshidaKunihiro
en-aut-sei=Yoshida
en-aut-mei=Kunihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KanemotoHideka
en-aut-sei=Kanemoto
en-aut-mei=Hideka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=CalderwoodStuart K.
en-aut-sei=Calderwood
en-aut-mei=Stuart K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=EguchiTakanori
en-aut-sei=Eguchi
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
kn-affil=

affil-num=5
en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=cell stress response
kn-keyword=cell stress response
en-keyword=heat shock protein 90 (HSP90)
kn-keyword=heat shock protein 90 (HSP90)
en-keyword=SCAN domain (SCAND)-containing proteins
kn-keyword=SCAN domain (SCAND)-containing proteins
en-keyword=MZF1
kn-keyword=MZF1
en-keyword=ZSCAN6
kn-keyword=ZSCAN6
en-keyword=heat shock factor (HSF)
kn-keyword=heat shock factor (HSF)
en-keyword=long noncoding RNA (lncRNA)
kn-keyword=long noncoding RNA (lncRNA)
en-keyword=co-expression correlation
kn-keyword=co-expression correlation
en-keyword=Kaplan-Meier plot
kn-keyword=Kaplan-Meier plot
en-keyword=cancer patient prognosis
kn-keyword=cancer patient prognosis
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=2183710
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Electrochemical control of bone microstructure on electroactive surfaces for modulation of stem cells and bone tissue engineering
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Controlling stem cell behavior at the material interface is crucial for the development of novel technologies in stem cell biology and regenerative medicine. The composition and presentation of bio-factors on a surface strongly influence the activity of stem cells. Herein, we designed an electroactive surface that mimics the initial process of trabecular bone formation, by immobilizing chondrocyte-derived plasma membrane nanofragments (PMNFs) on its surface for rapid mineralization within 2 days. Moreover, the electroactive surface was based on the conducting polymer polypyrrole (PPy), which enabled dynamic control of the presentation of PMNFs on the surface via electrochemical redox switching, further resulting in the formation of bone minerals with different morphologies. Furthermore, bone minerals with contrasting surface morphologies had differential effects on the differentiation of human bone marrow-derived stem cells (hBMSCs) cultured on the surface. Together, this electroactive surface showed multifunctional characteristics, not only allowing dynamic control of PMNF presentation but also promoting the formation of bone minerals with different morphologies within 2 days. This electroactive substrate could be valuable for more precise control of stem cell growth and differentiation, and further development of more suitable microenvironments containing bone apatite for housing a bone marrow stem cell niche, such as biochips/bone-on-chips.
en-copyright=
kn-copyright=

en-aut-name=CaoDanfeng
en-aut-sei=Cao
en-aut-mei=Danfeng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MartinezJose G.
en-aut-sei=Martinez
en-aut-mei=Jose G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AnadaRisa
en-aut-sei=Anada
en-aut-mei=Risa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HaraEmilio Satoshi
en-aut-sei=Hara
en-aut-mei=Emilio Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=JagerEdwin W. H.
en-aut-sei=Jager
en-aut-mei=Edwin W. H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Sensor and Actuator Systems, Department of Physics, Chemistry and Biology (IFM), Linköping University
kn-affil=

affil-num=2
en-affil=Sensor and Actuator Systems, Department of Physics, Chemistry and Biology (IFM), Linköping University
kn-affil=

affil-num=3
en-affil=Advanced Research Center for Oral and Craniofacial Sciences Dental School, Graduate School of Medicine, Dentistry and Pharmaceutical  Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Advanced Research Center for Oral and Craniofacial Sciences Dental School, Graduate School of Medicine, Dentistry and Pharmaceutical  Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Sensor and Actuator Systems, Department of Physics, Chemistry and Biology (IFM), Linköping University
kn-affil=
en-keyword=Polypyrrole
kn-keyword=Polypyrrole
en-keyword=plasma membrane
kn-keyword=plasma membrane
en-keyword=redox switching
kn-keyword=redox switching
en-keyword=bone
kn-keyword=bone
en-keyword=chip
kn-keyword=chip
en-keyword=organ-on-chip
kn-keyword=organ-on-chip
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=5
article-no=
start-page=4996
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230305
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The downregulation of SPRED2, a negative regulator of the ERK1/2 pathway, was previously detected in human cancers; however, the biological consequence remains unknown. Here, we investigated the effects of SPRED2 loss on hepatocellular carcinoma (HCC) cell function. Human HCC cell lines, expressing various levels of SPRED2 and SPRED2 knockdown, increased ERK1/2 activation. SPRED2-knockout (KO)-HepG2 cells displayed an elongated spindle shape with increased cell migration/invasion and cadherin switching, with features of epithelial-mesenchymal transition (EMT). SPRED2-KO cells demonstrated a higher ability to form spheres and colonies, expressed higher levels of stemness markers and were more resistant to cisplatin. Interestingly, SPRED2-KO cells also expressed higher levels of the stem cell surface markers CD44 and CD90. When CD44(+)CD90(+) and CD44(-)CD90(-) populations from WT cells were analyzed, a lower level of SPRED2 and higher levels of stem cell markers were detected in CD44(+)CD90(+) cells. Further, endogenous SPRED2 expression decreased when WT cells were cultured in 3D, but was restored in 2D culture. Finally, the levels of SPRED2 in clinical HCC tissues were significantly lower than those in adjacent non-HCC tissues and were negatively associated with progression-free survival. Thus, the downregulation of SPRED2 in HCC promotes EMT and stemness through the activation of the ERK1/2 pathway, and leads to more malignant phenotypes.
en-copyright=
kn-copyright=

en-aut-name=GaoTong
en-aut-sei=Gao
en-aut-mei=Tong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YangXu
en-aut-sei=Yang
en-aut-mei=Xu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujisawaMasayoshi
en-aut-sei=Fujisawa
en-aut-mei=Masayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OharaToshiaki
en-aut-sei=Ohara
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WangTianyi
en-aut-sei=Wang
en-aut-mei=Tianyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YoshimuraTeizo
en-aut-sei=Yoshimura
en-aut-mei=Teizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MatsukawaAkihiro
en-aut-sei=Matsukawa
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Cell Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=cancer stem cells
kn-keyword=cancer stem cells
en-keyword=epithelial-mesenchymal transition
kn-keyword=epithelial-mesenchymal transition
en-keyword=ERK1/2-MAPK
kn-keyword=ERK1/2-MAPK
en-keyword=tumorigenesis
kn-keyword=tumorigenesis
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=82
end-page=87
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Statistical evaluation of the effectiveness of dual amplitude-gated stereotactic body radiotherapy using fiducial markers and lung volume
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background and purpose: The low tracking accuracy of lung stereotactic body radiotherapy (SBRT) risks reduced treatment efficacy. We used four-dimensional computed tomography (4DCT) images to determine the correlation between changes in fiducial marker positions and lung volume for lung tumors, and we evaluated the effectiveness of the combined use of these images in lung SBRT.<br>
Materials and methods: Data of 30 patients who underwent fiducial marker placement were retrospectively analyzed. We calculated the motion amplitudes of the center of gravity coordinates of the lung tumor and fiducial markers in each phase and the ipsilateral, contralateral, and bilateral lung volumes using 4DCT. Moreover, we calculated the cross-correlation coefficient between the fiducial marker position and the lung volume changes waveform for the motion amplitude waveform of the lung tumor over three gating windows (all phases, ≤2 mm3, and ≤3 mm3).<br>
Results: Compared with the lung volume, approximately 30 % of the fiducial markers demonstrated a low correlation with the lung tumor. In the ≤2 mm3 and ≤3 mm3 gating windows, the cross-correlation coefficients between the lung tumor and the optimal marker (r > 0.9: 83 % and 86 %) were significantly different for all fiducial markers (r > 0.9: 39 %, 53 %) and the ipsilateral (r > 0.9: 35 % and 40 %), contralateral (r > 0.9: 44 % and 41 %), and bilateral (r > 0.9: 39 % and 45 %) lung volumes.<br>
Conclusions: Some of the fiducial markers showed a low correlation with the lung tumor. This study indicated that the combined use of lung volume monitoring can improve tracking accuracy.
en-copyright=
kn-copyright=

en-aut-name=TanabeYoshinori
en-aut-sei=Tanabe
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TanakaHidekazu
en-aut-sei=Tanaka
en-aut-mei=Hidekazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Radiation Oncology, Yamaguchi University Graduate School of Medicine
kn-affil=
en-keyword=Fiducial marker
kn-keyword=Fiducial marker
en-keyword=Respiratory gating method
kn-keyword=Respiratory gating method
en-keyword=Stereotactic body radiotherapy
kn-keyword=Stereotactic body radiotherapy
en-keyword=Tumor tracking
kn-keyword=Tumor tracking
en-keyword=Lung cancer
kn-keyword=Lung cancer
en-keyword=4DCT
kn-keyword=4DCT
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=1925
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230118
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Are Non-Invasive Modalities for the Assessment of Atherosclerosis Useful for Heart Failure Predictions?
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Heart failure (HF) is becoming an increasingly common issue worldwide and is associated with significant morbidity and mortality, making its prevention an important clinical goal. The criteria evaluated using non-invasive modalities such as coronary artery calcification, the ankle-brachial index, and carotid intima-media thickness have been proven to be effective in determining the relative risk of atherosclerotic cardiovascular disease. Notably, risk assessments using these modalities have been proven to be superior to the traditional risk predictors of cardiovascular disease. However, the ability to assess HF risk has not yet been well-established. In this review, we describe the clinical significance of such non-invasive modalities of atherosclerosis assessments and examine their ability to assess HF risk. The predictive value could be influenced by the left ventricular ejection fraction. Specifically, when the ejection fraction is reduced, its predictive value increases because this condition is potentially a result of coronary artery disease. In contrast, using these measures to predict HF with a preserved ejection fraction may be difficult because it is a heterogeneous condition. To overcome this issue, further research, especially on HF with a preserved ejection fraction, is required.
en-copyright=
kn-copyright=

en-aut-name=OsawaKazuhiro
en-aut-sei=Osawa
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyoshiToru
en-aut-sei=Miyoshi
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of General Internal Medicine 3, Kawasaki Medical School General Medical Center
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=heart failure
kn-keyword=heart failure
en-keyword=coronary artery calcification
kn-keyword=coronary artery calcification
en-keyword=ankle-brachial index
kn-keyword=ankle-brachial index
en-keyword=carotid intima-media thickness
kn-keyword=carotid intima-media thickness
en-keyword=cardio-ankle vascular index
kn-keyword=cardio-ankle vascular index
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=5
article-no=
start-page=4411
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230223
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Revisiting Cryptocyanine Dye, NK-4, as an Old and New Drug: Review and Future Perspectives
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=NK-4 plays a key role in the treatment of various diseases, such as in hay fever to expect anti-allergic effects, in bacterial infections and gum abscesses to expect anti-inflammatory effects, in scratches, cuts, and mouth sores from bites inside the mouth for enhanced wound healing, in herpes simplex virus (HSV)-1 infections for antiviral effects, and in peripheral nerve disease that causes tingling pain and numbness in hands and feet, while NK-4 is used also to expect antioxidative and neuroprotective effects. We review all therapeutic directions for the cyanine dye NK-4, as well as the pharmacological mechanism of NK-4 in animal models of related diseases. Currently, NK-4, which is sold as an over-the-counter drug in drugstores, is approved for treating allergic diseases, loss of appetite, sleepiness, anemia, peripheral neuropathy, acute suppurative diseases, wounds, heat injuries, frostbite, and tinea pedis in Japan. The therapeutic effects of NK-4’s antioxidant and neuroprotective properties in animal models are now under development, and we hope to apply these pharmacological effects of NK-4 to the treatment of more diseases. All experimental data suggest that different kinds of utility of NK-4 in the treatment of diseases can be developed based on the various pharmacological properties of NK-4. It is expected that NK-4 could be developed in more therapeutic strategies to treat many types of diseases, such as neurodegenerative and retinal degenerative diseases.
en-copyright=
kn-copyright=

en-aut-name=LiuShihui
en-aut-sei=Liu
en-aut-mei=Shihui
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsuoToshihiko
en-aut-sei=Matsuo
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AbeTakumi
en-aut-sei=Abe
en-aut-mei=Takumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=2926
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Expression of Acetabular Labral Vascular Endothelial Growth Factor and Nerve Growth Factor Is Directly Associated with Hip Osteoarthritis Pain: Investigation by Immunohistochemical Staining
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The acetabular labrum enhances hip joint stability and plays a key role in osteoarthritis (OA) progression. Labral nerve endings contribute to hip OA pain. Moreover, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) are associated with pain. Consequently, we analysed VEGF and NGF expression levels in the labrum and their roles in OA. Labra obtained from OA patients were stained immunohistochemically, and labral cells were cultured and subjected to a reverse transcription (RT)-polymerase chain reaction (PCR) to analyse VEGF and NGF mRNA expression. VEGF and NGF expression were compared in each region of the labrum. Correlations between VEGF and NGF expression and age, body mass index, Kellgren-Lawrence grade, Harris Hip Score, the visual analogue scale (VAS), and Krenn score were analysed, and the RT-PCR confirmed the findings. VEGF and NGF expression were high on the labral articular side, negatively correlated with the Krenn score, and positively correlated with the VAS in early OA. VEGF and NGF mRNA expression increased significantly in patients with severe pain and decreased significantly in severely degenerated labra. In early OA, VEGF and NGF expression in the acetabular labrum was associated with the occurrence of hip pain; therefore, these factors could be effective targets for pain management.
en-copyright=
kn-copyright=

en-aut-name=SatoYoshihiro
en-aut-sei=Sato
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TetsunagaTomonori
en-aut-sei=Tetsunaga
en-aut-mei=Tomonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamadaKazuki
en-aut-sei=Yamada
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawamuraYoshi
en-aut-sei=Kawamura
en-aut-mei=Yoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshidaAki
en-aut-sei=Yoshida
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Intelligent Orthopaedic System, Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Medical Materials for Musculoskeletal Reconstruction, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=hip osteoarthritis (OA)
kn-keyword=hip osteoarthritis (OA)
en-keyword=acetabular labrum
kn-keyword=acetabular labrum
en-keyword=vascular endothelial growth factor (VEGF)
kn-keyword=vascular endothelial growth factor (VEGF)
en-keyword=nerve growth factor (NGF)
kn-keyword=nerve growth factor (NGF)
en-keyword=immunochemical staining
kn-keyword=immunochemical staining
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=1921
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202302
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Microcalcification and Tc-99m-Pyrophosphate Uptake without Increased Bone Metabolism in Cardiac Tissue from Patients with Transthyretin Cardiac Amyloidosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Transthyretin cardiac amyloidosis (ATTR-CA) is characterized by high Tc-99m-labeled bone tracer uptake in the heart. However, the mechanism of bone tracer uptake into the heart remains controversial. Since bone tracer uptake into metastatic bone tumors is thought to be associated with increased bone metabolism, we examined Tc-99m-pyrophosphate (PYP) scintigraphy findings, endomyocardial biopsy (EMB) tissue findings, and the expression of bone metabolism-related genes in the EMB tissues in patients with ATTR-CA, amyloid light-chain cardiac amyloidosis (AL-CA), and noncardiac amyloidosis (non-CA) in this study. The uptake of Tc-99m-PYP in the heart was significantly higher in the ATTR-CA patients than in the AL-CA and non-CA patients. A higher percentage of ATTR-CA EMB tissue showed von Kossa-positive microparticles: ATTR-CA, 62%; AL-CA, 33%; and non-CA, 0%. Calcified microparticles were identified using transmission electron microscopy. However, none of the osteogenic marker genes, osteoclastic marker genes, or phosphate/pyrophosphate-related genes were upregulated in the EMB samples from ATTR-CA patients compared to those from AL-CA and non-CA patients. These results suggest that active calcification-promoting mechanisms are not involved in the microcalcification observed in the heart in ATTR-CA. The mechanisms explaining bone tracer uptake in the heart, which is stronger than that in the ribs, require further investigation.
en-copyright=
kn-copyright=

en-aut-name=MoriAtsushi
en-aut-sei=Mori
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SaitoYukihiro
en-aut-sei=Saito
en-aut-mei=Yukihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamuraKazufumi
en-aut-sei=Nakamura
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IidaToshihiro
en-aut-sei=Iida
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AkagiSatoshi
en-aut-sei=Akagi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YoshidaMasashi
en-aut-sei=Yoshida
en-aut-mei=Masashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TaniyamaMakiko
en-aut-sei=Taniyama
en-aut-mei=Makiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MiyoshiToru
en-aut-sei=Miyoshi
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Medicine, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Chronic Kidney Disease and Cardiovascular Disease, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of General Medicine, Tamano Division, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=ATTR
kn-keyword=ATTR
en-keyword=Tc-99m-labeled bone scintigraphy
kn-keyword=Tc-99m-labeled bone scintigraphy
en-keyword=calcified microparticle
kn-keyword=calcified microparticle
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=822
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230103
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cycloartenyl Ferulate Is the Predominant Compound in Brown Rice Conferring Cytoprotective Potential against Oxidative Stress-Induced Cytotoxicity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since brown rice extract is a rich source of biologically active compounds, the present study is aimed to quantify the major compounds in brown rice and to compare their cytoprotective potential against oxidative stress. The content of the main hydrophobic compounds in brown rice followed the order of cycloartenyl ferulate (CAF) (89.00 +/- 8.07 nmol/g) >> alpha-tocopherol (alpha T) (19.73 +/- 2.28 nmol/g) > gamma-tocotrienol (gamma T3) (18.24 +/- 1.41 nmol/g) > alpha-tocotrienol (alpha T3) (16.02 +/- 1.29 nmol/g) > gamma-tocopherol (gamma T) (3.81 +/- 0.40 nmol/g). However, the percent contribution of CAF to the radical scavenging activity of one gram of whole brown rice was similar to those of alpha T, alpha T3, and gamma T3 because of its weaker antioxidant activity. The CAF pretreatment displayed a significant cytoprotective effect on the hydrogen peroxide-induced cytotoxicity from 10 mu M, which is lower than the minimal concentrations of alpha T and gamma T required for a significant protection. CAF also enhanced the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation coincided with the enhancement of the heme oxygenase-1 (HO-1) mRNA level. An HO-1 inhibitor, tin protoporphyrin IX (SnPP), significantly impaired the cytoprotection of CAF. The cytoprotective potential of CAF is attributable to its cycloartenyl moiety besides the ferulyl moiety. These results suggested that CAF is the predominant cytoprotector in brown rice against hydrogen peroxide-induced cytotoxicity.
en-copyright=
kn-copyright=

en-aut-name=WuHongyan
en-aut-sei=Wu
en-aut-mei=Hongyan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraToshiyuki
en-aut-sei=Nakamura
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=GuoYingnan
en-aut-sei=Guo
en-aut-mei=Yingnan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsumotoRiho
en-aut-sei=Matsumoto
en-aut-mei=Riho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=School of Food Science and Technology, Dalian Polytechnic University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=School of Food Science and Technology, Dalian Polytechnic University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=cycloartenyl ferulate
kn-keyword=cycloartenyl ferulate
en-keyword=antioxidative effect
kn-keyword=antioxidative effect
en-keyword=cytoprotective potential
kn-keyword=cytoprotective potential
en-keyword=heme oxygenase-1
kn-keyword=heme oxygenase-1
en-keyword=nuclear factor erythroid 2-related factor 2
kn-keyword=nuclear factor erythroid 2-related factor 2
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=755
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230101
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Metformin and Its Immune-Mediated Effects in Various Diseases
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Metformin has been a long-standing prescribed drug for treatment of type 2 diabetes (T2D) and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are also recognized. Metformin modulates the differentiation and activation of various immune-mediated cells such as CD4+ and CD+8 T cells. The activation of adenosine 5 '-monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1) pathway may be involved in this process. Recent studies using Extracellular Flux Analyzer demonstrated that metformin alters the activities of glycolysis, oxidative phosphorylation (OXPHOS), lipid oxidation, and glutaminolysis, which tightly link to the modulation of cytokine production in CD4+ and CD+8 T cells in various disease states, such as virus infection, autoimmune diseases, aging and cancers.
en-copyright=
kn-copyright=

en-aut-name=NojimaIchiro
en-aut-sei=Nojima
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=CD8 T cells
kn-keyword=CD8 T cells
en-keyword=AMPK
kn-keyword=AMPK
en-keyword=mTORC
kn-keyword=mTORC
en-keyword=OXPHOS
kn-keyword=OXPHOS
en-keyword=autoimmune disease
kn-keyword=autoimmune disease
en-keyword=aging
kn-keyword=aging
en-keyword=cancer
kn-keyword=cancer
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=裏表紙・英文目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=奥付
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=執筆者紹介
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=39
end-page=41
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Summary of Research Activities : Okayama Administrative Law Research Group
kn-title=岡山行政法実務研究会　研究会記録（第33回～第35回）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Okayama Administrative Law Research Group
en-aut-sei=Okayama Administrative Law Research Group
en-aut-mei=
kn-aut-name=岡山行政法実務研究会
kn-aut-sei=岡山行政法実務研究会
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=27
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Constitutional Theory of Public Transportation and Traffic Regulation in the Region
kn-title=地域における公共交通と交通規制のあり方をめぐる憲法論～2020年司法試験論述問題・公法系第１問（憲法）を素材として～
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AraiMakoto
en-aut-sei=Arai
en-aut-mei=Makoto
kn-aut-name=新井誠
kn-aut-sei=新井
kn-aut-mei=誠
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=広島大学大学院人間社会科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=17
end-page=25
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Enhancing Initial Response to Expanding and Intensifying Disasters 　― Thinking about the Future Disaster Prevention System after the Heavy Rain Disaster of July 2018 ―
kn-title=広域化、激甚化する災害への初動対応の充実に向けて ～平成30年7月豪雨災害から今後の防災体制を考える～
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YoshidaKunishige
en-aut-sei=Yoshida
en-aut-mei=Kunishige
kn-aut-name=吉田邦成
kn-aut-sei=吉田
kn-aut-mei=邦成
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=元　岡山県危機管理監
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=1
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Comment on Case ― What is the Serious Illegality ? ―
kn-title=緊急逮捕手続書の虚偽記載が重大な違法にあたるとされた事例 ―山形地裁令和4年2月21日判決―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KouraMiho
en-aut-sei=Koura
en-aut-mei=Miho
kn-aut-name=小浦美保
kn-aut-sei=小浦
kn-aut-mei=美保
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学学術研究院法務学域
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙・目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=42
article-no=
start-page=7845
end-page=7849
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221020
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Total Synthesis of Scabrolide F
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The first total synthesis of scabrolide F, a norcembranolide isolated from the soft coral Sinularia scabra, is described. Hydroxycarboxylic acid, which is the key synthetic intermediate, was synthesized in a convergent manner by fragment coupling. The obtained hydroxycarboxylic acid was subjected to macrolactonization and subsequent transannular ring-closing metathesis (RCM) to furnish scabrolide F. The synthetic protocol can be extended to the total synthesis of other norcembranolides.
en-copyright=
kn-copyright=

en-aut-name=TakamuraHiroyoshi
en-aut-sei=Takamura
en-aut-mei=Hiroyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugitaniYuki
en-aut-sei=Sugitani
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MorishitaRyohei
en-aut-sei=Morishita
en-aut-mei=Ryohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KadotaIsao
en-aut-sei=Kadota
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=60
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Patients with triple-negative breast cancer (TNBC) often have poorer prognosis than those with other subtypes because of its aggressive behaviors. Cancer cells are heterogeneous, and only a few highly metastatic subclones metastasize. Although the majority of subclones may not metastasize, they could contribute by releasing factors that increase the capacity of highly metastatic cells and/or provide a favorable tumor microenvironment (TME). Here, we analyzed the interclonal communication in TNBC which leads to efficient cancer progression, particularly lung metastasis, using the polyclonal murine 4T1 BC model. Methods We isolated two 4T1 subclones, LM.4T1 and HM.4T1 cells with a low and a high metastatic potential, respectively, and examined the effects of LM.4T1 cells on the behaviors of HM.4T1 cells using the cell scratch assay, sphere-forming assay, sphere invasion assay, RT-qPCR, and western blotting in vitro. We also examined the contribution of LM.4T1 cells to the lung metastasis of HM.4T1 cells and TME in vivo. To identify a critical factor which may be responsible for the effects by LM.4T1 cells, we analyzed the data obtained from the GEO database. Results Co-injection of LM.4T1 cells significantly augmented lung metastases by HM.4T1 cells. LM.4T1-derived exosomes promoted the migration and invasion of HM.4T1 cells in vitro, and blocking the secretion of exosome abrogated their effects on HM.4T1 cells. Analyses of data obtained from the GEO database suggested that Wnt7a might be a critical factor responsible for the enhancing effects. In fact, a higher level of Wnt7a was detected in LM.4T1 cells, especially in exosomes, than in HM.4T1 cells, and deletion of Wnt7a in LM.4T1 cells significantly decreased the lung metastasis of HM.4T1 cells. Further, treatment with Wnt7a increased the spheroid formation by HM.4T1 cells via activation of the PI3K/Akt/mTOR signaling pathway. Finally, infiltration of alpha SMA-positive fibroblasts and angiogenesis was more prominent in tumors of LM.4T1 cells and deletion of Wnt7a in LM.4T1 cells markedly reduced angiogenesis. Conclusions We demonstrated, for the first time, that a low metastatic subclone can enhance lung metastasis of highly metastatic subclone via exosomal Wnt7a and propose Wnt7a as a molecular target to treat TNBC patients.
en-copyright=
kn-copyright=

en-aut-name=LiChunning
en-aut-sei=Li
en-aut-mei=Chunning
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YoshimuraTeizo
en-aut-sei=Yoshimura
en-aut-mei=Teizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TianMiao
en-aut-sei=Tian
en-aut-mei=Miao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WangYuze
en-aut-sei=Wang
en-aut-mei=Yuze
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KondoTakamasa
en-aut-sei=Kondo
en-aut-mei=Takamasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamamotoKen-Ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=FujisawaMasayoshi
en-aut-sei=Fujisawa
en-aut-mei=Masayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OharaToshiaki
en-aut-sei=Ohara
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MatsukawaAkihiro
en-aut-sei=Matsukawa
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Pathology and Experimental Medicine, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Pathology and Experimental Medicine, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Pathology and Experimental Medicine, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Pathology and Experimental Medicine, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Pathology and Experimental Medicine, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Pathology and Experimental Medicine, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Pathology and Experimental Medicine, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Pathology and Experimental Medicine, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Cell Biology,  Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Pathology and Experimental Medicine, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Breast cancer
kn-keyword=Breast cancer
en-keyword=Metastasis
kn-keyword=Metastasis
en-keyword=Exosomes
kn-keyword=Exosomes
en-keyword=Epithelial mesenchymal transition
kn-keyword=Epithelial mesenchymal transition
en-keyword=Tumor microenvironment
kn-keyword=Tumor microenvironment
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=6
article-no=
start-page=780
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Transition Probability Test for an RO-Based Generator and the Relevance between the Randomness and the Number of ROs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A ring oscillator is a well-known circuit used for generating random numbers, and interested readers can find many research results concerning the evaluation of the randomness with a packaged test suit. However, the authors think there is room for evaluating the unpredictability of a sequence from another viewpoint. In this paper, the authors focus on Wold's RO-based generator and propose a statistical test to numerically evaluate the randomness of the RO-based generator. The test adopts the state transition probabilities in a Markov process and is designed to check the uniformity of the probabilities based on hypothesis testing. As a result, it is found that the RO-based generator yields a biased output from the viewpoint of the transition probability if the number of ROs is small. More precisely, the transitions 01 -> 01 and 11 -> 11 happen frequently when the number l of ROs is less than or equal to 10. In this sense, l > 10 is recommended for use in any application, though a packaged test suit is passed. Thus, the authors believe that the proposed test contributes to evaluating the unpredictability of a sequence when used together with available statistical test suits, such as NIST SP800-22.
en-copyright=
kn-copyright=

en-aut-name=KoderaYuta
en-aut-sei=Kodera
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SatoRyoichi
en-aut-sei=Sato
en-aut-mei=Ryoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AliMd Arshad
en-aut-sei=Ali
en-aut-mei=Md Arshad
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KusakaTakuya
en-aut-sei=Kusaka
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NogamiYasuyuki
en-aut-sei=Nogami
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Computer Science and Engineering, Hajee Mohammad Danesh Science and Technology University (HSTU)
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=true random number generator
kn-keyword=true random number generator
en-keyword=ring oscillator
kn-keyword=ring oscillator
en-keyword=Markov process
kn-keyword=Markov process
en-keyword=hypothesis testing
kn-keyword=hypothesis testing
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=5
article-no=
start-page=781
end-page=792
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160915
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Design of Function for Tracing Diffusion of Classified Information for IPC on KVM
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The leaking of information has increased in recent years. To address this problem, we previously proposed a function for tracing the diffusion of classified information in a guest OS using a virtual machine monitor (VMM). This function makes it possible to grasp the location of classified information and detect information leakage without modifying the source codes of the guest OS. The diffusion of classified information is caused by the file operation, child process creation, and inter-process communication (IPC). In a previous study, we implemented the proposed function for a file operation and child process creation excluding IPC using a kernel-based virtual machine (KVM). In this paper, we describe the design of the proposed function for IPC on a KVM without modifying the guest OS. The proposed function traces the local and remote IPCs inside the guest OS from the outside so as to trace the information diffusion. Because IPC with an outside computer might cause an information leakage, tracing the IPCs enables the detection of such a leakage. We also report the evaluation results including the traceability and performance of the proposed function.
en-copyright=
kn-copyright=

en-aut-name=FujiiShota
en-aut-sei=Fujii
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SatoMasaya
en-aut-sei=Sato
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamauchiToshihiro
en-aut-sei=Yamauchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TaniguchiHideo
en-aut-sei=Taniguchi
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Information Leakage Prevention
kn-keyword=Information Leakage Prevention
en-keyword=Inter-Process Communication
kn-keyword=Inter-Process Communication
en-keyword=Virtualization
kn-keyword=Virtualization
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=18
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211023
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Synthesis and characterization of conductive flexible cellulose carbon nanohorn sheets for human tissue applications
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background<br>
Conductive sheets of cellulose and carbon nanomaterials and its human skin applications are an interesting research aspect as they have potential for applications for skin compatibility. Hence it is needed to explore the effects and shed light on these applications.<br>
Method<br>
To fabricate wearable, portable, flexible, lightweight, inexpensive, and biocompatible composite materials, carbon nanohorns (CNHs) and hydroxyethylcellulose (HEC) were used as precursors to prepare CNH-HEC (Cnh-cel) composite sheets. Cnh-cel sheets were prepared with different loading concentrations of CNHs (10, 20 50,100mg) in 200mg cellulose. To fabricate the bio-compatible sheets, a pristine composite of CNHs and HEC was prepared without any pretreatment of the materials.<br>
Results<br>
The obtained sheets possess a conductivity of 1.83x10(-10)S/m and bio-compatible with human skin. Analysis for skin-compatibility was performed for Cnh-cel sheets by h-CLAT in vitro skin sensitization tests to evaluate the activation of THP-1 cells. It was found that THP-1 cells were not activated by Cnh-cel; hence Cnh-cel is a safe biomaterial for human skin. It was also found that the composite allowed only a maximum loading of 100mg to retain the consistent geometry of free-standing sheets of <100<mu>m thickness. Since CNHs have a unique arrangement of aggregates (dahlia structure), the composite is homogeneous, as verified by transmission electron microscopy (TEM) and, scanning electron microscopy (SEM), and other functional properties investigated by Raman spectroscopy, Fourier transform infrared spectroscopy (FT-IR), conductivity measurement, tensile strength measurement, and skin sensitization.<br>
Conclusion<br>
It can be concluded that cellulose and CNHs sheets are conductive and compatible to human skin applications.
en-copyright=
kn-copyright=

en-aut-name=SelvamKarthik Paneer
en-aut-sei=Selvam
en-aut-mei=Karthik Paneer
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NagahataTaichi
en-aut-sei=Nagahata
en-aut-mei=Taichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KatoKosuke
en-aut-sei=Kato
en-aut-mei=Kosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KoreishiMayuko
en-aut-sei=Koreishi
en-aut-mei=Mayuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraToshiyuki
en-aut-sei=Nakamura
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NishikawaTakeshi
en-aut-sei=Nishikawa
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SatohAyano
en-aut-sei=Satoh
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HayashiYasuhiko
en-aut-sei=Hayashi
en-aut-mei=Yasuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Carbon Nanohorns
kn-keyword=Carbon Nanohorns
en-keyword=Cellulose
kn-keyword=Cellulose
en-keyword=Skin sensitization
kn-keyword=Skin sensitization
en-keyword=Composites
kn-keyword=Composites
en-keyword=Bio-compatible
kn-keyword=Bio-compatible
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=5
article-no=
start-page=367
end-page=382
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201214
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mechanisms Underlying the Comorbidity of Schizophrenia and Type 2 Diabetes Mellitus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The mortality rate of patients with schizophrenia is high, and life expectancy is shorter by 10 to 20 years. Metabolic abnormalities including type 2 diabetes mellitus (T2DM) are among the main reasons. The prevalence of T2DM in patients with schizophrenia may be epidemiologically frequent because antipsychotics induce weight gain as a side effect and the cognitive dysfunction of patients with schizophrenia relates to a disordered lifestyle, poor diet, and low socioeconomic status. Apart from these common risk factors and risk factors unique to schizophrenia, accumulating evidence suggests the existence of common susceptibility genes between schizophrenia and T2DM. Functional proteins translated from common genetic susceptibility genes are known to regulate neuronal development in the brain and insulin in the pancreas through several common cascades. In this review, we discuss common susceptibility genes, functional cascades, and the relationship between schizophrenia and T2DM. Many genetic and epidemiological studies have reliably associated the comorbidity of schizophrenia and T2DM, and it is probably safe to think that common cascades and mechanisms suspected from common genes' functions are related to the onset of both schizophrenia and T2DM. On the other hand, even when genetic analyses are performed on a relatively large number of comorbid patients, the results are sometimes inconsistent, and susceptibility genes may carry only a low or moderate risk. We anticipate future directions in this field.
en-copyright=
kn-copyright=

en-aut-name=MizukiYutaka
en-aut-sei=Mizuki
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SakamotoShinji
en-aut-sei=Sakamoto
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkahisaYuko
en-aut-sei=Okahisa
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YadaYuji
en-aut-sei=Yada
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HashimotoNozomu
en-aut-sei=Hashimoto
en-aut-mei=Nozomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakakiManabu
en-aut-sei=Takaki
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamadaNorihito
en-aut-sei=Yamada
en-aut-mei=Norihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=DISC1
kn-keyword=DISC1
en-keyword=kalirin
kn-keyword=kalirin
en-keyword=ARHGEF11
kn-keyword=ARHGEF11
en-keyword=Akt/GSK3 beta
kn-keyword=Akt/GSK3 beta
en-keyword=Wnt beta-catenin
kn-keyword=Wnt beta-catenin
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=23
end-page=28
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Steep posterior slope of the medial tibial plateau is associated with ramp lesions of the medial meniscus and a concomitant anterior cruciate ligament injury
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Medial meniscus (MM) tears are associated with both acute and chronic anterior cruciate ligament (ACL) insufficiency and can lead to degenerative changes in the knee. ACL reconstruction (ACLR) combined with the meniscal repair was reported to result in decreased anterior knee joint laxity with evidence of improved patient-reported outcomes in the long term. However, a subtle tear of the MM posterior segment, also known as a ramp lesion, is difficult to detect on conventional magnetic resonance imaging (MRI) and is frequently missed in ACL-deficient knees. However, there are few studies about the associations between bone geometry and ramp lesion of the MM. This study aimed to compare sagittal medial tibial slope (MTS), medial tibial plateau depth (MTPD), and coronal tibial slope (CTS) between ACL-injured knees with and without ramp lesion of the MM. We hypothesised that patients with ramp lesion of the MM and a concomitant ACL injury have a steeper MTS and shallower MTPD than those without ramp lesion of the MM. Methods: Twenty-seven patients who underwent ACLR (group A), and 15 patients with combined MM repair (group AM) were included in the study. Anterior tibial translation (ATT) was measured under general anaesthesia just before surgery using a knee arthrometer. MRI was performed in the 10 degrees-knee-flexed position. The MTS and MTPD were measured on sagittal view, and the CTS was measured on coronal view. These parameters were compared between the groups. Differences in MRI measurements or patient demographics between the groups were evaluated using the Mann-Whitney U test. Results: No significant difference was observed in demographic data and post-operative side-to-side difference in ATT between both groups. Pre-operative ATT was significantly higher in group AM than in group A (P < 0.05), whereas post-operative ATT was similar in both groups. Further, Pre-operative ATT was significantly higher in patients with MTS >= 5.0 degrees than in those with MTS <5.0 degrees (P < 0.05). In groups A and AM, the MTS were 3.6 degrees +/- 1.8 degrees and 6.2 degrees +/- 2.9 degrees, the MTPD were 2.0 +/- 0.5 mm and 2.1 +/- 0.6 mm, and the CTS were 2.5 degrees +/- 1.8 degrees and 2.4 degrees +/- 1.6 degrees, respectively. Patients in group AM had a significantly steeper MTS compared to those in group A (P < 0.01), whereas MTPD and CTS were nearly the same in both groups. When the MTS cut-off value was set at 5.0 degrees, the sensitivity and specificity for ACL injury with concomitant ramp lesion of the MM were 0.73 and 0.76, respectively. Conclusion: A steep posterior slope of the medial tibial plateau is a risk factor for ramp lesion of the MM associated with an ACL injury. Especially in patients with MTS >= 5.0 degrees, an occult MM ramp lesion should be strongly suspected, and surgeons should prepare for MM repair in combination with ACLR.
en-copyright=
kn-copyright=

en-aut-name=OkazakiYuki
en-aut-sei=Okazaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HiranakaTakaaki
en-aut-sei=Hiranaka
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KintakaKeisuke
en-aut-sei=Kintaka
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KodamaYuya
en-aut-sei=Kodama
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KamatsukiYusuke
en-aut-sei=Kamatsuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Anterior cruciate ligament
kn-keyword=Anterior cruciate ligament
en-keyword=Ramp lesion
kn-keyword=Ramp lesion
en-keyword=Risk factor
kn-keyword=Risk factor
en-keyword=Magnetic resonance imaging
kn-keyword=Magnetic resonance imaging
en-keyword=Proximal tibial geometry
kn-keyword=Proximal tibial geometry
en-keyword=Medial tibial slope
kn-keyword=Medial tibial slope
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=376
end-page=382
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Swarming and mating behavior in Ephemera orientalis Mclachlan, 1875 (Ephemeroptera: Ephemeridae) with morphological analyses
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Swarming and mating behaviors of a mayfly species, Ephemera orientalis Mclachlan, 1875 were observed in 2015, 2016, and 2018 at a river bank of the Asahi River, Japan. Males started to make swarms between late April and middle May in 2016 and 2018. The numbers of mated pairs in a swarm correlated with the numbers of flying males in a swarm in 2016 and 2018. Swarms were formed during a limited period at dusk most probably because that interval is free from natural enemies. Males competed with each other to copulate with females in swarms. We clarified the function of the forelegs of males, which are significantly longer than those of females. Males used their forelegs to hold up a female from below. Besides forelegs, males have longer tails than females. We will discuss why sexual differences are found in these traits. Our results represent the first observation of swarm mating behavior in E. orientalis.
en-copyright=
kn-copyright=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugeTaichi
en-aut-sei=Suge
en-aut-mei=Taichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzakiShunsuke
en-aut-sei=Suzaki
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanabeShintaro
en-aut-sei=Tanabe
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshiharaRyo
en-aut-sei=Ishihara
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Aquatic insect
kn-keyword=Aquatic insect
en-keyword=Emergence
kn-keyword=Emergence
en-keyword=Copulation
kn-keyword=Copulation
en-keyword=Foreleg
kn-keyword=Foreleg
en-keyword=Mayfly
kn-keyword=Mayfly
en-keyword=Swarm
kn-keyword=Swarm
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=13
article-no=
start-page=2495
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190708
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=BACKGROUND/AIM:Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers.<br/>
METHODS:The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model.<br/>
RESULTS:A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, 1H-NMR and 13C-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 µg/mL, respectively.<br/>
CONCLUSION:Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet.
en-copyright=
kn-copyright=

en-aut-name=ZahraMaram Hussein
en-aut-sei=Zahra
en-aut-mei=Maram Hussein
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SalemTarek A. R.
en-aut-sei=Salem
en-aut-mei=Tarek A. R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=El-AaragBishoy
en-aut-sei=El-Aarag
en-aut-mei=Bishoy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YosriNermeen
en-aut-sei=Yosri
en-aut-mei=Nermeen
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=EL-GhlbanSamah
en-aut-sei=EL-Ghlban
en-aut-mei=Samah
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ZakiKholoud
en-aut-sei=Zaki
en-aut-mei=Kholoud
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MareiAmel H.
en-aut-sei=Marei
en-aut-mei=Amel H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=Abd El-WahedAida
en-aut-sei=Abd El-Wahed
en-aut-mei=Aida
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SaeedAamer
en-aut-sei=Saeed
en-aut-mei=Aamer
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KhatibAlfi
en-aut-sei=Khatib
en-aut-mei=Alfi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AlAjmiMohamed F.
en-aut-sei=AlAjmi
en-aut-mei=Mohamed F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=ShathiliAbdulrahman M.
en-aut-sei=Shathili
en-aut-mei=Abdulrahman M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=XiaoJianbo
en-aut-sei=Xiao
en-aut-mei=Jianbo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KhalifaShaden A. M.
en-aut-sei=Khalifa
en-aut-mei=Shaden A. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=El-SeediHesham R.
en-aut-sei=El-Seedi
en-aut-mei=Hesham R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Biochemistry, College of Medicine, Qassim University
kn-affil=

affil-num=3
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=5
en-affil=Biochemistry Division, Chemistry Department, Faculty of Science, Menoufia University
kn-affil=

affil-num=6
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=7
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=8
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=9
en-affil=Department of Chemistry, Quaid-i-Azam University
kn-affil=

affil-num=10
en-affil=Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia
kn-affil=

affil-num=11
en-affil=Pharmacognosy Group, College of Pharmacy, King Saud University
kn-affil=

affil-num=12
en-affil=Al-Rayan Research and Innovation Center, Al-Rayan Colleges
kn-affil=

affil-num=13
en-affil=Institute of Chinese Medical Sciences, University of Macau
kn-affil=

affil-num=14
en-affil=Clinical Research Centre, Karolinska University Hospital
kn-affil=

affil-num=15
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
en-keyword=Alpinia zerumbet
kn-keyword=Alpinia zerumbet
en-keyword=5,6-dehydrokawain
kn-keyword=5,6-dehydrokawain
en-keyword=Ehrlich ascites carcinoma
kn-keyword=Ehrlich ascites carcinoma
en-keyword=anti-tumor
kn-keyword=anti-tumor
en-keyword=anti-oxidant
kn-keyword=anti-oxidant
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=18
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190911
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The current study aimed to synthesize new metal coordination complexes with potential biomedical applications. Metal complexes were prepared via the reaction of isatin-N(4)anti- pyrinethiosemicarbazone ligand 1 with Cu(II), Ni(II), Co(II), Zn(II), and Fe(III) ions. The obtained metal complexes 2–12 were characterized using elemental, spectral (1H-NMR, EPR, Mass, IR, UV-Vis) and thermal (TGA) techniques, as well as magnetic moment and molar conductance measurements. In addition, their geometries were studied using EPR and UV–Vis spectroscopy. To evaluate the in vivo anti-cancer activities of these complexes, the ligand 1 and its metal complexes 2, 7 and 9 were tested against solid tumors. The solid tumors were induced by subcutaneous (SC) injection of Ehrlich ascites carcinoma (EAC) cells in mice. The impact of the selected complexes on the reduction of tumor volume was determined. Also, the expression levels of vascular endothelial growth factor (VEGF) and cysteine aspartyl-specific protease-7 (caspase-7) in tumor and liver tissues of mice bearing EAC tumor were determined. Moreover, their effects on alanine transaminase (ALT), aspartate transaminase (AST), albumin, and glucose levels were measured. The results revealed that the tested compounds, especially complex 9, reduced tumor volume, inhibited the expression of VEGF, and induced the expression of caspase-7. Additionally, they restored the levels of ALT, AST, albumin, and glucose close to their normal levels. Taken together, our newly synthesized metal complexes are promising anti-cancer agents against solid tumors induced by EAC cells as supported by the inhibition of VEGF and induction of caspase-7.
en-copyright=
kn-copyright=

en-aut-name=El-SaiedFathy
en-aut-sei=El-Saied
en-aut-mei=Fathy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=El-AaragBishoy
en-aut-sei=El-Aarag
en-aut-mei=Bishoy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SalemTarek
en-aut-sei=Salem
en-aut-mei=Tarek
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SaidGhada
en-aut-sei=Said
en-aut-mei=Ghada
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KhalifaShaden A. M.
en-aut-sei=Khalifa
en-aut-mei=Shaden A. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=El-SeediHesham R.
en-aut-sei=El-Seedi
en-aut-mei=Hesham R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=2
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Molecular Biology, Genetic Engineering & Biotechnology Institute, University of Sadat City
kn-affil=

affil-num=4
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=5
en-affil=Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
kn-affil=

affil-num=6
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
en-keyword=metal complexes
kn-keyword=metal complexes
en-keyword=isatin-N(4)antipyrinethiosemicarbazone
kn-keyword=isatin-N(4)antipyrinethiosemicarbazone
en-keyword=Ehrlich ascites carcinoma
kn-keyword=Ehrlich ascites carcinoma
en-keyword=tumor volume
kn-keyword=tumor volume
en-keyword=VEGF
kn-keyword=VEGF
en-keyword=caspase-7
kn-keyword=caspase-7
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=8
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190416
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Melittin Exerts Beneficial Effects on Paraquat-Induced Lung Injuries in Mice by Modifying Oxidative Stress and Apoptosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Melittin (MEL) is a 26-amino acid peptide with numerous biological activities. Paraquat (PQ) is one of the most widely used herbicides, although it is extremely toxic to humans. To date, PQ poisoning has no effective treatment, and therefore the current study aimed to assess for the first time the possible effects of MEL on PQ-induced lung injuries in mice. Mice received a single intraperitoneal (IP) injection of PQ (30 mg/kg), followed by IP treatment with MEL (0.1 and 0.5 mg/kg) twice per week for four consecutive weeks. Histological alterations, oxidative stress, and apoptosis in the lungs were studied. Hematoxylin and eosin (H&E) staining indicated that MEL markedly reduced lung injuries induced by PQ. Furthermore, treatment with MEL increased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity, and decreased malonaldehyde (MDA) and nitric oxide (NO) levels in lung tissue homogenates. Moreover, immunohistochemical staining showed that B-cell lymphoma-2 (Bcl-2) and survivin expressions were upregulated after MEL treatment, while Ki-67 expression was downregulated. The high dose of MEL was more effective than the low dose in all experiments. In summary, MEL efficiently reduced PQ-induced lung injuries in mice. Specific pharmacological examinations are required to determine the effectiveness of MEL in cases of human PQ poisoning.
en-copyright=
kn-copyright=

en-aut-name=El-AaragBishoy
en-aut-sei=El-Aarag
en-aut-mei=Bishoy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MagdyMohamed
en-aut-sei=Magdy
en-aut-mei=Mohamed
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AlAjmiMohamed F.
en-aut-sei=AlAjmi
en-aut-mei=Mohamed F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KhalifaShaden A. M.
en-aut-sei=Khalifa
en-aut-mei=Shaden A. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=El-SeediHesham R.
en-aut-sei=El-Seedi
en-aut-mei=Hesham R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=3
en-affil=Department of Pharmacognosy, College of Pharmacy, King Saud University
kn-affil=

affil-num=4
en-affil=Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
kn-affil=

affil-num=5
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
en-keyword=paraquat
kn-keyword=paraquat
en-keyword=lung injury
kn-keyword=lung injury
en-keyword=melittin
kn-keyword=melittin
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=apoptosis
kn-keyword=apoptosis
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=11
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190605
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel. 
en-copyright=
kn-copyright=

en-aut-name=WangNing
en-aut-sei=Wang
en-aut-mei=Ning
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ŚwitalskaMarta
en-aut-sei=Świtalska
en-aut-mei=Marta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangLi 
en-aut-sei=Wang
en-aut-mei=Li 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShabanElkhabiry
en-aut-sei=Shaban
en-aut-mei=Elkhabiry
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HossainMd Imran
en-aut-sei=Hossain
en-aut-mei=Md Imran
kn-aut-name=  
kn-aut-sei=
kn-aut-mei=  
aut-affil-num=5
ORCID=

en-aut-name=El SayedIbrahim El Tantawy 
en-aut-sei=El Sayed
en-aut-mei=Ibrahim El Tantawy 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=WietrzykJoanna
en-aut-sei=Wietrzyk
en-aut-mei=Joanna
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=InokuchiTsutomu
en-aut-sei=Inokuchi
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
kn-affil=

affil-num=3
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=7
en-affil=Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
kn-affil=

affil-num=8
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=cryptolepine
kn-keyword=cryptolepine
en-keyword=neocryptolepine
kn-keyword=neocryptolepine
en-keyword=isocryptolepine
kn-keyword=isocryptolepine
en-keyword=antiproliferative activity
kn-keyword=antiproliferative activity
en-keyword=structure activity relationships
kn-keyword=structure activity relationships
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=6
article-no=
start-page=1058
end-page=1063
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190820
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Posttraumatic cartilage degradation progresses following anterior cruciate ligament reconstruction: A second-look arthroscopic evaluation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=BACKGROUND:<br/>
Several studies have demonstrated that posttraumatic knee osteoarthritis progresses even after anterior cruciate ligament reconstruction. Few reports described zone-specific cartilaginous damages after anterior cruciate ligament reconstruction. This study aimed to compare the status of articular cartilage at anterior cruciate ligament reconstruction with that at second-look arthroscopy.<br/>
METHODS:<br/>
This study included 20 patients (20 knees, 10 males and 10 females, mean age 22.4 years, Body mass index 24.4 kg/m2) that underwent arthroscopic anatomic double-bundle anterior cruciate ligament reconstruction and second-look arthroscopy. Mean periods from injury to reconstruction and from reconstruction to second-look arthroscopy were 3.4 and 15.3 months, respectively. Cartilage lesions were evaluated arthroscopically in the 6 articular surfaces and 40 articular subcompartments independently, and these features were graded with the International Cartilage Repair Society articular cartilage injury classification; comparisons were made between the grades at reconstruction and at second-look arthroscopy. Furthermore, clinical outcomes were assessed at reconstruction and at second-look arthroscopy, using the Lysholm knee score, Tegner activity scale, International Knee Documentation Committee score, Knee injury and Osteoarthritis Outcome Score, side-to-side difference of the KT-2000 arthrometer, and pivot shift test.<br/>
RESULTS:<br/>
Each compartment showed a deteriorated condition at second-look arthroscopy compared with the pre-reconstruction period. A significant worsening of the articular cartilage was noted in all compartments except the lateral tibial plateau and was also observed in the central region of the medial femoral condyle and trochlea after reconstruction. However, each clinical outcome was significantly improved postoperatively.<br/>
CONCLUSIONS:<br/>
Good cartilage conditions were restored in most subcompartments at second-look arthroscopy. Furthermore, posttraumatic osteoarthritic changes in the patellofemoral and medial compartments progressed even in the early postoperative period, although good knee stability and clinical outcomes were obtained. Care is necessary regarding the progression of osteoarthritis and the appearance of knee symptoms in patients undergoing anterior cruciate ligament reconstruction.
en-copyright=
kn-copyright=

en-aut-name=HiranakaTakaaki
en-aut-sei=Hiranaka
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KamatsukiYusuke
en-aut-sei=Kamatsuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SugiuKazuhisa
en-aut-sei=Sugiu
en-aut-mei=Kazuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OkazakiYoshiki
en-aut-sei=Okazaki
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MasudaShin
en-aut-sei=Masuda
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkazakiYuki
en-aut-sei=Okazaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakihiraShota
en-aut-sei=Takihira
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MiyazawaShinichi
en-aut-sei=Miyazawa
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Intelligent Orthopaedic System Development, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Musculoskeletal Traumatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=377
end-page=381
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A rare manifestation of extraskeletal myxoid chondrosarcoma with a huge expanding hematoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OmoriToshinori
en-aut-sei=Omori
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KunisadaToshiyuki
en-aut-sei=Kunisada
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakedaKen
en-aut-sei=Takeda
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HaseiJoe
en-aut-sei=Hasei
en-aut-mei=Joe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YoshidaAki
en-aut-sei=Yoshida
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YanaiHiroyuki
en-aut-sei=Yanai
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Diagnostic Pathology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=337
end-page=341
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mini-open excision of osteoid osteoma using intraoperative O-arm/Stealth navigation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background</br>
Although osteoid osteomas have traditionally been treated by surgical excision, radiofrequency ablation (RFA) has gained favor as a less invasive procedure. However, RFA is contraindicated for osteoid osteomas close to the skin or crucial neurovascular structures, and is not covered by national health insurance in Japan. The aim of the present study was to evaluate the efficacy of surgical excision of osteoid osteomas using intraoperative navigation.</br>
Methods</br>
We performed a retrospective review of five patients with osteoid osteoma who underwent a mini-open excision using O-arm/Stealth navigation at our institution. The osteoid osteomas were excised using a cannulated cutter or curetted out with the assistance of navigation.</br>
Results</br>
Complete excision was achieved in all patients, which was confirmed by pathological examination. The mean skin incision was 2.1 cm (range, 1.5 to 3.0 cm) and the mean duration required for setup three-dimensional image was 15 min (range, 12 to 20 min). Although the mean visual analog scale score was 7 (range, 4 to 8) before surgery, all patients experienced relief from their characteristic pain immediately after surgery, with the mean scores of 2.2 (range, 1 to 3) and 0 at 2 days and 4 weeks after surgery, respectively. There was no intra-operative complication related to the navigation and no recurrence was observed during the mean follow-up period of 25 months (range, 13 to 33 months).</br>
Conclusions</br>
Mini-open excision using intraoperative O-arm/Stealth navigation is a safe and accurate procedure for patients with osteoid osteoma, which could cover the limitation of RFA.
en-copyright=
kn-copyright=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KunisadaToshiyuki
en-aut-sei=Kunisada
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakedaKen
en-aut-sei=Takeda
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HaseiJoe
en-aut-sei=Hasei
en-aut-mei=Joe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MochizukiYusuke
en-aut-sei=Mochizuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KiyonoMasahiro
en-aut-sei=Kiyono
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YoshidaAki
en-aut-sei=Yoshida
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=奥付
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境理工学部
kn-aut-sei=岡山大学環境理工学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=55
end-page=56
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=2018年 環境理工学部 博士論文 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境理工学部
kn-aut-sei=岡山大学環境理工学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=53
end-page=54
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=2018年 環境理工学部 研究受賞等 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境理工学部
kn-aut-sei=岡山大学環境理工学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=39
end-page=52
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=2018年 環境物質工学科 学術論文等 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境理工学部
kn-aut-sei=岡山大学環境理工学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=21
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=2018年 環境管理工学科 学術論文等 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境理工学部
kn-aut-sei=岡山大学環境理工学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=20
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=2018年 環境デザイン工学科 学術論文等 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境理工学部
kn-aut-sei=岡山大学環境理工学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=2018年 環境数理学科 学術論文等 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境理工学部
kn-aut-sei=岡山大学環境理工学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=目次 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境理工学部
kn-aut-sei=岡山大学環境理工学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境理工学部
kn-aut-sei=岡山大学環境理工学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=368
end-page=371
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=201803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=小論文自動採点データ構築と理解力および妥当性評価手法の構築
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OhnoMasayuki
en-aut-sei=Ohno
en-aut-mei=Masayuki
kn-aut-name=大野雅幸
kn-aut-sei=大野
kn-aut-mei=雅幸
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=泉仁宏太
kn-aut-sei=泉仁
kn-aut-mei=宏太
aut-affil-num=2
ORCID=

en-aut-name=TakeuchiKoichi
en-aut-sei=Takeuchi
en-aut-mei=Koichi
kn-aut-name=竹内孔一
kn-aut-sei=竹内
kn-aut-mei=孔一
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小畑友也
kn-aut-sei=小畑
kn-aut-mei=友也
aut-affil-num=4
ORCID=

en-aut-name=TaguchiMasahiro
en-aut-sei=Taguchi
en-aut-mei=Masahiro
kn-aut-name=田口雅弘
kn-aut-sei=田口
kn-aut-mei=雅弘
aut-affil-num=5
ORCID=

en-aut-name=InadaYoshihiko
en-aut-sei=Inada
en-aut-mei=Yoshihiko
kn-aut-name=稲田佳彦
kn-aut-sei=稲田
kn-aut-mei=佳彦
aut-affil-num=6
ORCID=

en-aut-name=IizukaMasaya
en-aut-sei=Iizuka
en-aut-mei=Masaya
kn-aut-name=飯塚誠也
kn-aut-sei=飯塚
kn-aut-mei=誠也
aut-affil-num=7
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=阿保達彦
kn-aut-sei=阿保
kn-aut-mei=達彦
aut-affil-num=8
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=上田均
kn-aut-sei=上田
kn-aut-mei=均
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=3
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=4
en-affil=
kn-affil=岡山大学工学

affil-num=5
en-affil=
kn-affil=岡山大学院社会文化科学研究

affil-num=6
en-affil=
kn-affil=岡山大学院教育学研究科

affil-num=7
en-affil=
kn-affil=岡山大学全学教育・学生支援機構

affil-num=8
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=9
en-affil=
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=裏表紙・目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Department of Earth Sciences, Faculty of Science, Okayama University 
en-aut-sei=Department of Earth Sciences, Faculty of Science, Okayama University 
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学地球科学研究報告 投稿規定（約款）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Department of Earth Sciences, Faculty of Science, Okayama University 
en-aut-sei=Department of Earth Sciences, Faculty of Science, Okayama University 
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=5
end-page=18
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Interdisciplinary class for high school students on the climate environment around Japan and "seasonal feeling" expressed in the school songs with attention to the asymmetric seasonal march from autumn to the next spring
kn-title=日本の気候環境と愛唱歌などにみる季節感に関する高校での学際的授業の開発（冬を挟む日本の季節進行の非対称性に注目して）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= This study is a part of the activity to develop an interdisciplinary lesson plan for high school students on the climate environment around Japan and the "seasonal feeling". This time, we focused our attention to the asymmetric seasonal march from autumn to the next spring as proposed by Kato et al. (2013). Comparison of the climate between early winter and early spring was made in the class not only on that around the Japan but also on the relation to the larger-scale systems such as the Siberian air mass, including the brief data analysis. The students also compared the detailed "seasonal feeling" between the two seasons expressed in the school songs and the Japanese classic poems called "Wa-Ka". This paper reports the contents and results of this joint activity at the two high schools.
en-copyright=
kn-copyright=

en-aut-name=KatoKuranoshin
en-aut-sei=Kato
en-aut-mei=Kuranoshin
kn-aut-name=加藤内藏進
kn-aut-sei=加藤
kn-aut-mei=内藏進
aut-affil-num=1
ORCID=

en-aut-name=KatoHaruko
en-aut-sei=Kato
en-aut-mei=Haruko
kn-aut-name=加藤晴子
kn-aut-sei=加藤
kn-aut-mei=晴子
aut-affil-num=2
ORCID=

en-aut-name=MiyakeShoji
en-aut-sei=Miyake
en-aut-mei=Shoji
kn-aut-name=三宅昭二
kn-aut-sei=三宅
kn-aut-mei=昭二
aut-affil-num=3
ORCID=

en-aut-name=MoriTaizo
en-aut-sei=Mori
en-aut-mei=Taizo
kn-aut-name=森泰三
kn-aut-sei=森
kn-aut-mei=泰三
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科（理科）

affil-num=2
en-affil=Faculty of Education, Gufu Shotoku Gakuen University
kn-affil=岐阜聖徳学園大学教育学部（音楽）

affil-num=3
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科（理科）

affil-num=4
en-affil=Okayama-Ichinomiya High School
kn-affil=岡山県一宮高等学校（地理）
en-keyword= Interdisciplinary activity on climate and cultural understanding education
kn-keyword= Interdisciplinary activity on climate and cultural understanding education
en-keyword= Climate environment around Japan
kn-keyword= Climate environment around Japan
en-keyword=Seasonal cycle and "seasonal feeling"
kn-keyword=Seasonal cycle and "seasonal feeling"
en-keyword=Asymmetric seasonal march from autumn to the next spring
kn-keyword=Asymmetric seasonal march from autumn to the next spring
en-keyword=ESD
kn-keyword=ESD
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=4
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Rounded pebble of metamorphosed iron-formations from conglomerate of the Miocene deposits in Yatakayama, Kibi Plateau, Okayama Prefecture
kn-title=岡山県吉備高原弥高山地域に分布する中新統礫岩から変成鉄鉱石礫の発見
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The Kibi Plateau was a part of the Eurasian Continent and separated by the event of opening of Japan Sea. The rounded pebble which is considered to be continental origin was discovered. The pebble is siliceous and attracts magnets. Prepared thin-sections were observed under microscope. Selected minerals were analyzed by EPMA. The rock is composed of recrystallized quartz, magnetite, riebeckite, stilpnomelane and associated with very tiny minerals with very high relief and interference colors. The assemblage suggests that there is a possibility that the rock is a metamorphic rock of iron-formations and derived from continent.
en-copyright=
kn-copyright=

en-aut-name=SuzukiShigeyuki
en-aut-sei=Suzuki
en-aut-mei=Shigeyuki
kn-aut-name=鈴木茂之
kn-aut-sei=鈴木
kn-aut-mei=茂之
aut-affil-num=1
ORCID=

en-aut-name=小網晴男
en-aut-sei=小網
en-aut-mei=晴男
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=臼井まゆみ
en-aut-sei=臼井
en-aut-mei=まゆみ
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科

affil-num=2
en-affil=Okayama Prefectural Okayama Asahi Senior High School
kn-affil=岡山県立岡山朝日高等学校

affil-num=3
en-affil=Fujigakuin-Okayama
kn-affil=富士学院
en-keyword=Continental origin
kn-keyword=Continental origin
en-keyword=Miocene conglomerate
kn-keyword=Miocene conglomerate
en-keyword=rounded pebble
kn-keyword=rounded pebble
en-keyword=iron-formations
kn-keyword=iron-formations
en-keyword=Kibi Plateau
kn-keyword=Kibi Plateau
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Title Page
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Department of Earth Sciences, Faculty of Science, Okayama University 
en-aut-sei=Department of Earth Sciences, Faculty of Science, Okayama University 
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙・英文目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Department of Earth Sciences, Faculty of Science, Okayama University 
en-aut-sei=Department of Earth Sciences, Faculty of Science, Okayama University 
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=1
end-page=54
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Annual report, Institute of Plant Science and Resources, Okayama University
kn-title=岡山大学資源植物科学研究所報告24巻
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name= Institute of Plant Science and Resources, Okayama University
en-aut-sei= Institute of Plant Science and Resources, Okayama University
en-aut-mei=
kn-aut-name=岡山大学資源植物科学研究所
kn-aut-sei=岡山大学資源植物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=奥付
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学算数・数学教育学会 
kn-aut-sei=岡山大学算数・数学教育学会 
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学算数・数学教育学会誌規定
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学算数・数学教育学会 
kn-aut-sei=岡山大学算数・数学教育学会 
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学算数・数学教育学会会則
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学算数・数学教育学会 
kn-aut-sei=岡山大学算数・数学教育学会 
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第24回　岡山大学算数・数学教育学会「談話会」報告
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学算数・数学教育学会 
kn-aut-sei=岡山大学算数・数学教育学会 
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=学会だより
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学算数・数学教育学会 
kn-aut-sei=岡山大学算数・数学教育学会 
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=53
end-page=65
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=「数学的な見方・考え方」と「深い学び」とのつながりについての考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　平成29年3月31日，新学習指導要領が告示された。算数科の目標は，「数学的な見方・考え方を働かせ～」の言葉から始まっている。この「数学的な見方・考え方」とは何か。算数科では算数的活動という言葉を数学的活動に変えて，充実を求めている。数学的活動は算数的活動とどう違うのか。新指導要領では「どのように学ぶか」に応えて「主体的・対話的で深い学び」による不断の授業改善を求めている。この「深い学び」とはどのような学びなのか。新しい小学校学習指導要領解説算数編では，「深い学び」の鍵として「見方・考え方」を働かせることが重要であると述べられているが，この2つはどのようにつながっているのか。
「深い学び」とは，算数科の新しい数学的活動（問題解決の過程を遂行すること）の一部である。子どもが考えを振り返り「統合・発展」していく過程のことであり，そこで気付いた「数学的な見方・考え方」のよさを自覚していくことだと考える。具体的な授業場面を通して，「数学的な見方・考え方」と「深い学び」とのつながりを考察する。
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=杉能道明
kn-aut-sei=杉能
kn-aut-mei=道明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=ノートルダム清心女子大学
en-keyword=数学的な見方・考え方
kn-keyword=数学的な見方・考え方
en-keyword=深い学び
kn-keyword=深い学び
en-keyword=数学的活動
kn-keyword=数学的活動
en-keyword=統合的・発展的
kn-keyword=統合的・発展的
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=47
end-page=52
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=次期学習指導要領での新領域「データの活用」における一考察 : 小学校算数第6学年の『データの考察』を通して
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= 本年度、2017年3月に小学校学習指導要領が、続く6月にその解説が改訂された。中でも、新たな領域「Dデータの活用」での第6学年における学習事項では、現行同様、度数分布表・柱状グラフが扱われるとはいえ、統計的な問題解決活動や結論の妥当性についての批判的な考察が取り入れられ、新たな教科書には大きな改変が見込まれる。
本稿では、現行の教科書に関する分析を更に行い、また次期学習指導要領・同解説を精査し、特徴や問題点を吟味する。このことは次期教科書に求められる対応につながる考察となる。
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=富永雅
kn-aut-sei=富永
kn-aut-mei=雅
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=大阪教育大学初等教育講座
en-keyword=小学校学習指導要・同解説
kn-keyword=小学校学習指導要・同解説
en-keyword=データの活用
kn-keyword=データの活用
en-keyword=算数科教科書
kn-keyword=算数科教科書
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=39
end-page=46
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=統合的者え方を育てる「図形の面積」の授業の構想（2) : ひし形の面積公式の適用範囲を広げる実践を遇して
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　次期学習指導要領の目標には「数学的な見方・考え方を働かせ、数学的活動を通して、数学的に考える資質・能力を次の通り育成することを目指す。」と述べ（ 2 ）で「～、基礎的・基本的な数量や図形の性質などを見いだし統舎的・発展的に考察する力、～を養う。」ことを述べている。
そこで、本稿では「数学的な考え方」の中でも、特に、「統合的・発展的考え方」の「統合的考え方」に的を絞り、「高次への統合」「包含的統合」「拡張的統合」を育てるための、5年生「図形の面積」の授業の構想とともに、ひし形の面積の公式の適用範囲を広げる「高次への統合」の実践を行った。その構想に基づいた授業実践を省察し、実践の成果と課題を明確にした。
その結果、統合的に考えることの良さを、多くの児童が感得したことが分かった。
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山野定寿
kn-aut-sei=山野
kn-aut-mei=定寿
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山県真庭市立中津井小学綬
en-keyword=数学的考え方
kn-keyword=数学的考え方
en-keyword=統合・発展的考え方
kn-keyword=統合・発展的考え方
en-keyword=数学的活動
kn-keyword=数学的活動
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=33
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=主体的・対話的で深い学びの実現に向けた算数科の授業づくり : 第5学年「四角形の内角の和」の実践を通して
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　平成29年6月に示された文部科学省『小学校学習指導要領解説総則編』では，各教科等において，主体的・対話的で深い学びの実現に向けた授業改善を行うこと，その際，各教科等の「見方・考え方」を働かせ，各教科等の学習の過程を重視して充実を図ることが示されている。
算数科では，「数学的な見方・考え方を働かせながら，日常の事象を数理的に捉え，数学の問題を見いだし，問題を自立的，協働的に解決し，学習の過程を振り返り，概念を形成するなどの学習の充実を図ること」が求められている。
本研究では，第5学年「四角形の内角の和」の実践を通して，主体的・対話的で深い学びの実現に向けた授業づくりについて考察を行った。
en-copyright=
kn-copyright=

en-aut-name=Nobukiyo
en-aut-sei=Nobukiyo
en-aut-mei=
kn-aut-name=信清亜希子
kn-aut-sei=信清
kn-aut-mei=亜希子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教育学部附属小学校
en-keyword=四角形の内角の和
kn-keyword=四角形の内角の和
en-keyword=主体的・対話的で深い学び
kn-keyword=主体的・対話的で深い学び
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=25
end-page=32
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=統計的な見方・考え方の育成に関する実践研究（ I ) : 小学校第3学年「表とグラフ」の指導を通して
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　本研究の目的は、統計的な見方・考え方の大まかな枠組みと、それを基にした各学年における統計的な見方・考え方を作成し、その指導可能性と妥当性を実践授業において検討することで、統計的な見方・考え方を具体化・体系化することである。
本事例では、小学校第3学年における統計的な見方・考え方を想定し、実践を通してその指導可能性と妥当性を検討した。
その結果、棒グラフの棒の長さといった見た目や表の不十分さを批判的に考察する姿が観察されたことから、本研究で想定した統計的な見方・考え方の枠組みの妥当性が高まったと考えられる。今後は、授業実践を通して第3学年以外における統計的な見方・考え方の具体化を図り、体系的な指導の在り方を探求したい。
en-copyright=
kn-copyright=

en-aut-name=KusachiTakayuki
en-aut-sei=Kusachi
en-aut-mei=Takayuki
kn-aut-name=草地貴幸
kn-aut-sei=草地
kn-aut-mei=貴幸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教育学部附属小学校
en-keyword=統計的な見方・考え方
kn-keyword=統計的な見方・考え方
en-keyword=批判的な考察
kn-keyword=批判的な考察
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=15
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=「主体的・対話的で深い学び」の実現を目指す授業改善の在り方に関する研究 : 低学年における統計指導を通して
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　2017年3月に新たに学習指導要領（2017a）が告示され，これからの教育の向かっていく方向性として，「資質・能力の育成」や「主体的・対話的で深い学びの伴った授業」が読み取れる。
また，中央教育審議会答申（2016a）から，「社会生活などの様々な場面において，必要なデーターを収集して分析し，その傾向を踏まえて課題を解決したり意思決定をしたりすること」が求められており，学習指導要領（2017a）では，新領域として，「データの活用」が設定され，内容の系統や各学年での指導の重点について明確にされ，統計教育の充実が図られている。
情報化がめまぐるしく進むこの時代において，統計教育の在り方が重要視されている今日における，統計教育の初期指導の在り方と低学年における授業デザインについて提案していく。
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=圓井大介
kn-aut-sei=圓井
kn-aut-mei=大介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山市立津島小学校
en-keyword=「主体的・対話的で深い学び」
kn-keyword=「主体的・対話的で深い学び」
en-keyword=「統計指導」
kn-keyword=「統計指導」
en-keyword=「表とグラフ」
kn-keyword=「表とグラフ」
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=9
end-page=14
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=深い学びを実現させる「整数」の授業づくり
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　本研究の目的は，深い学びの実現を目指し，数学的に考える資質・能力を育成するための授業づくりを追究することである。新学習指導要領が公示され，育成すべき数学的に考える資質・能力などが明らかになった。深い学びを実現させることで，その資質・能力を児童に獲得させる必要がある。本事例研究では，特に第5学年の「整数Jについての事例研究を取り上げる。2カ年にわたる授業実践から深い学びを促す数学的活動の工夫が，「整数」の性質としての理解の獲得につながることを明らかにする。
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山崎湧太
kn-aut-sei=山崎
kn-aut-mei=湧太
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山市立福島小学校
en-keyword=「深い学び」
kn-keyword=「深い学び」
en-keyword=「数学的に考える資質・能力」
kn-keyword=「数学的に考える資質・能力」
en-keyword=「数学的活動」
kn-keyword=「数学的活動」
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=「数学的な見方・考え方を働かせる」授業 : 新しい算数教育へのパラダイムの転換
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　AIの進展による変動の激しい時代を生きる子どもには、如何に社会が変動しようとも、能動的に対応できる資質・能力の育成が叫ばれている。算数教育においても、新しい資質・能力の育成が求められ、新学習指導要領の算数科の総括呂標には「数学的な見方・考え方を働かせ、数学的活動を通して、数学的に考える資質・能力の育成を目指す」という方向性が告示された。従前の育成すべき「数学的見方・考え方」の位置づけが、目的ではなく、数学的活動や数学的に考えるための「機能する道具」として位置付けられている。本研究では、数学的な見方・考え方の位置づけが変更された意図実現にむけ、新しく算数教育において「数学的な見方・考え方を働かせる」ことによって、従前の算数教育をどのように授業改善すべきかを検討する。
en-copyright=
kn-copyright=

en-aut-name=KurosakiToyoo
en-aut-sei=Kurosaki
en-aut-mei=Toyoo
kn-aut-name=黒崎東洋郎
kn-aut-sei=黒崎
kn-aut-mei=東洋郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山理科大学
en-keyword=数学的な見方・考え方
kn-keyword=数学的な見方・考え方
en-keyword=機能する道具
kn-keyword=機能する道具
en-keyword=文脈的なアプローチ
kn-keyword=文脈的なアプローチ
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=巻頭言 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HiraiYasuhisa
en-aut-sei=Hirai
en-aut-mei=Yasuhisa
kn-aut-name=平井安久
kn-aut-sei=平井
kn-aut-mei=安久
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教育学部
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学算数・数学教育学会 
kn-aut-sei=岡山大学算数・数学教育学会 
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学算数・数学教育学会 
kn-aut-sei=岡山大学算数・数学教育学会 
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=288
end-page=298
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201703
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of a Japanese version of the BREAST-Q and the traditional psychometric test of the mastectomy module for the assessment of HRQOL and patient satisfaction following breast surgery
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=BACKGROUND:　
An understanding of health-related quality of life (HRQOL) is of utmost importance in both oncological and esthetic breast surgery. The BREAST-Q is a patient-reported outcome (PRO) measure that investigates HRQOL and patient satisfaction before and after breast surgery. The aim of this study was to develop a Japanese version of the BREAST-Q including the mastectomy module, the reconstruction module, the augmentation module and the reduction/mastopexy module, and to assess the psychometric properties of the mastectomy module among Japanese women.　
METHODS:　
The Japanese version of the BREAST-Q was developed through forward translation, backward translation and patient testing. Traditional psychometric testing of the mastectomy module was administered to 45 post-mastectomy patients.　
RESULTS:　
The mastectomy, reconstruction, augmentation and reduction/mastopexy modules were formally developed into Japanese. Despite cultural difference between Japanese women and original target population, the contents were considered to be valid among Japanese woman. With the exception of the sexual well-being subscale, good reliability and validity were evident for the mastectomy module (Test-retest reliability 0.76-0.95, Chronbach's alpha coefficient 0.77-0.98).　
CONCLUSIONS:　
The BREAST-Q Japanese version is a useful PRO measure for investigating the impact of breast surgery on HRQOL and patient satisfaction. Further validation in younger Japanese women is needed to determine the usefulness of the sexual well-being subscale.
en-copyright=
kn-copyright=

en-aut-name=SaigaMiho
en-aut-sei=Saiga
en-aut-mei=Miho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TairaNaruto
en-aut-sei=Taira
en-aut-mei=Naruto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KimataYoshihiro
en-aut-sei=Kimata
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WatanabeSatoko
en-aut-sei=Watanabe
en-aut-mei=Satoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MukaiYuko
en-aut-sei=Mukai
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShimozumaKojiro
en-aut-sei=Shimozuma
en-aut-mei=Kojiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MizooTaeko
en-aut-sei=Mizoo
en-aut-mei=Taeko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NogamiTomohiro
en-aut-sei=Nogami
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IwamotoTakayuki
en-aut-sei=Iwamoto
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MotokiTakayuki
en-aut-sei=Motoki
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=ShienTadahiko
en-aut-sei=Shien
en-aut-mei=Tadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=DoiharaHiroyoshi
en-aut-sei=Doihara
en-aut-mei=Hiroyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University
kn-affil=

affil-num=7
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=
en-keyword=BREAST-Q
kn-keyword=BREAST-Q
en-keyword=Breast cancer
kn-keyword=Breast cancer
en-keyword=Breast reconstruction
kn-keyword=Breast reconstruction
en-keyword=Health-related quality of life
kn-keyword=Health-related quality of life
en-keyword=Satisfaction
kn-keyword=Satisfaction
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=593
end-page=600
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201707
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Accuracy assessment methods of tissue marker clip placement after 11-gauge vacuum-assisted stereotactic breast biopsy: comparison of measurements using direct and conventional methods
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=BACKGROUND:　
The objective of the study was to compare direct measurement with a conventional method for evaluation of clip placement in stereotactic vacuum-assisted breast biopsy (ST-VAB) and to evaluate the accuracy of clip placement using the direct method.　
METHODS:　
Accuracy of clip placement was assessed by measuring the distance from a residual calcification of a targeted calcification clustered to a clip on a mammogram after ST-VAB. Distances in the craniocaudal (CC) and mediolateral oblique (MLO) views were measured in 28 subjects with mammograms recorded twice or more after ST-VAB. The difference in the distance between the first and second measurements was defined as the reproducibility and was compared with that from a conventional method using a mask system with overlap of transparent film on the mammogram. The 3D clip-to-calcification distance was measured using the direct method in 71 subjects.　
RESULTS:　
The reproducibility of the direct method was higher than that of the conventional method in CC and MLO views (P = 0.002, P < 0.001). The median 3D clip-to-calcification distance was 2.8 mm, with an interquartile range of 2.0-4.8 mm and a range of 1.1-36.3 mm.　
CONCLUSION:　
The direct method used in this study was more accurate than the conventional method, and gave a median 3D distance of 2.8 mm between the calcification and clip.
en-copyright=
kn-copyright=

en-aut-name=YatakeHidetoshi
en-aut-sei=Yatake
en-aut-mei=Hidetoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SawaiYuka
en-aut-sei=Sawai
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishiToshio
en-aut-sei=Nishi
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakanoYoshiaki
en-aut-sei=Nakano
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishimaeAyaka
en-aut-sei=Nishimae
en-aut-mei=Ayaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KatsudaToshizo
en-aut-sei=Katsuda
en-aut-mei=Toshizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YabunakaKoichi
en-aut-sei=Yabunaka
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakedaYoshihiro
en-aut-sei=Takeda
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=InajiHideo
en-aut-sei=Inaji
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Radiology, Breast Cancer Center, Kaizuka City Hospital
kn-affil=

affil-num=2
en-affil= Department of Radiology, Breast Cancer Center, Kaizuka City Hospital
kn-affil=

affil-num=3
en-affil= Department of Breast Surgery, Breast Cancer Center, Kaizuka City Hospital
kn-affil=

affil-num=4
en-affil=Department of Breast Surgery, Breast Cancer Center, Kaizuka City Hospital
kn-affil=

affil-num=5
en-affil=Department of Breast Surgery, Breast Cancer Center, Kaizuka City Hospital
kn-affil=

affil-num=6
en-affil=Department of Health Science, Osaka Butsuryo University
kn-affil=

affil-num=7
en-affil=Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, University of Tokyo
kn-affil=

affil-num=8
en-affil= Graduate School of Health Science, Okayama University
kn-affil=

affil-num=9
en-affil= Department of Breast Surgery, Breast Cancer Center, Kaizuka City Hospital
kn-affil=
en-keyword=Breast cancer
kn-keyword=Breast cancer
en-keyword=Direct methods
kn-keyword=Direct methods
en-keyword=Mammography
kn-keyword=Mammography
en-keyword=Mask methods
kn-keyword=Mask methods
en-keyword=Stereotactic vacuum assisted biopsy
kn-keyword=Stereotactic vacuum assisted biopsy
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=奥付
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学文学部
kn-aut-sei=岡山大学文学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=33
end-page=94
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=イラストレイテド・ロンドン・ニュースに見る19世紀後半のビルマ（ミャンマー）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WatanabeYoshinari
en-aut-sei=Watanabe
en-aut-mei=Yoshinari
kn-aut-name=渡邊佳成
kn-aut-sei=渡邊
kn-aut-mei=佳成
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=21
end-page=31
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=From Image to Icon : Making of the Idea of Representation
kn-title=イメージ（像）からイコン（聖像）へ : 表象論の成立
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SuzukiMichitaka
en-aut-sei=Suzuki
en-aut-mei=Michitaka
kn-aut-name=鐸木道剛
kn-aut-sei=鐸木
kn-aut-mei=道剛
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=9
end-page=19
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=錦絵新聞に描かれた欧米人
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SasakiMoritoshi
en-aut-sei=Sasaki
en-aut-mei=Moritoshi
kn-aut-name=佐々木守俊
kn-aut-sei=佐々木
kn-aut-mei=守俊
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=みたび印画紙に焼き付けられた西太后
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YusaToru
en-aut-sei=Yusa
en-aut-mei=Toru
kn-aut-name=遊佐徹
kn-aut-sei=遊佐
kn-aut-mei=徹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=はじめに
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学文学部
kn-aut-sei=岡山大学文学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学文学部
kn-aut-sei=岡山大学文学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学文学部
kn-aut-sei=岡山大学文学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=121
end-page=152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19951218
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A List of Characters in Feng-Shen-Yen-I  -- A Study of Feng-Shen-Yen-I (封神演義) (1)
kn-title=『封神演義』人物表 ――『封神演義』研究の1――
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YusaToru
en-aut-sei=Yusa
en-aut-mei=Toru
kn-aut-name=遊佐徹
kn-aut-sei=遊佐
kn-aut-mei=徹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=33
end-page=57
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19951218
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A post -Skinnerian perspective in behavior analysis (5) : Preventing contingencies
kn-title=スキナー以後の行動分析学(5) 阻止の随伴性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HasegawaYoshinori
en-aut-sei=Hasegawa
en-aut-mei=Yoshinori
kn-aut-name=長谷川芳典
kn-aut-sei=長谷川
kn-aut-mei=芳典
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=6
article-no=
start-page=670
end-page=675
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=201411
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Little is known about the immunological milieu of the skin-draining lymph nodes (LNs) in mycosis fungoides (MF). Objectives: We studied dendritic cell (DC) subsets in the dermatopathic lymphadenitis of MF patients. Methods: We immunohistochemically examined DC subsets and their distribution in 16 LN samples from 14 patients with MF (N1 LN, eight patients; N2, four; and N3, four), and we compared them with non-metastatic sentinel LNs from eight patients with melanoma. Results: The number of S-100 protein+ DCs was markedly increased in the LNs from the MF patients and the major component was DC-LAMP+ mature DCs in the outer and paracortex areas, where DC-SIGN+ immature DCs were relatively decreased in proportion. In contrast, DC-SIGN+ cells were relatively increased in proportion compared to DC-LAMP+ cells in the medulla. Although no significant difference was observed in the proportions of CD1a+ or Langerin+ DCs among the N1, N2, and N3 nodes, CD163+ M2-type macrophages were increased in number in the N2 and N3 nodes. Conclusions: Our observations indicate that mature DCs accumulate in the outer and paracortex areas in dermatopathic lymphadenitis and M2-type macrophages might increase in number during disease progression.
en-copyright=
kn-copyright=

en-aut-name=TadaKotaro
en-aut-sei=Tada
en-aut-mei=Kotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HamadaToshihisa
en-aut-sei=Hamada
en-aut-mei=Toshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AsagoeKenji
en-aut-sei=Asagoe
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UmemuraHiroshi
en-aut-sei=Umemura
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=Mizuno-IkedaKazuko
en-aut-sei=Mizuno-Ikeda
en-aut-mei=Kazuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AoyamaYumi
en-aut-sei=Aoyama
en-aut-mei=Yumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OtsukaMasaki
en-aut-sei=Otsuka
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YamasakiOsamu
en-aut-sei=Yamasaki
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IwatsukiKeiji
en-aut-sei=Iwatsuki
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Dermatology, Okayama Medical Center

affil-num=4
en-affil=
kn-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=7
en-affil=
kn-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=8
en-affil=
kn-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=9
en-affil=
kn-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
en-keyword=Mycosis fungoides
kn-keyword=Mycosis fungoides
en-keyword=dendritic cell
kn-keyword=dendritic cell
en-keyword=dermatopathic lymphadenitis
kn-keyword=dermatopathic lymphadenitis
en-keyword=DC-LAMP
kn-keyword=DC-LAMP
en-keyword=DC-SIGN
kn-keyword=DC-SIGN
en-keyword=M2-type macrophage
kn-keyword=M2-type macrophage
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=3
end-page=6
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=201306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=First Synthesis of Asperopterin A, an Isoxanthopterin Glycoside from Aspergillus Oryzae
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The key precursor, N-2-(N,N -dimethylaminomethylene)-6-hydroxymethyl-8-methyl-3-[2-(4-nitrophenyl)ethyl]-7-xanthopterin (16) was efficiently prepared from 2,5-diamino-6-methylamino-3H-pyrimidin-4-one (5) and ethyl 3-(tert-butyldimethylsilyloxy)-2-oxopropionate (12), followed by the protection of the pteridine ring. Glycosylation of 16 with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose (18) in the presence of tin(IV) chloride yielded the corresponding beta-D-ribofuranoside. Successive removal of the protecting groups of the resulting D-ribofuranoside provided asperopterin A (4b).
en-copyright=
kn-copyright=

en-aut-name=HanayaTadashi
en-aut-sei=Hanaya
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoHiroshi
en-aut-sei=Yamamoto
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Fac Sci, Dept Chem

affil-num=2
en-affil=
kn-affil=Shujitsu Univ, Sch Pharm
en-keyword=asperopterin
kn-keyword=asperopterin
en-keyword=glycosylation
kn-keyword=glycosylation
en-keyword=isoxanthopterin
kn-keyword=isoxanthopterin
en-keyword=protecting groups
kn-keyword=protecting groups
en-keyword=pterin glycoside
kn-keyword=pterin glycoside
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=198402
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=成羽町の歴史と現在 : 岡山県成羽町
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学教育学部社会科教室内地域研究会
kn-aut-sei=岡山大学教育学部社会科教室内地域研究会
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=10
article-no=
start-page=566
end-page=571
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Vascularized peripheral nerve grafting promotes myelination of regrowing optic nerve
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated whether the use of vascularized peripheral nerve grafts on the optic nerve stump enhances axonal regeneration of retinal ganglion cells compared with isolated nonvascularized grafts. The rat median nerve was microsurgically sutured with its supplying artery and vein to the optic nerve stump. The number of retinal ganglion cells with regenerating axons was evaluated by retrograde labeling into the grafted peripheral nerve, and the myelination of the regenerating axon fibers was examined by electron microscopy. The number of retinal ganglion cells with regenerating axons was significantly higher in the vascularized graft than in the nonvascularized graft. The ratio of myelinated axon fibers was also increased in vascularized grafts. Thus, grafting with their supplying arteries and veins to an injured nerve stump represents a promising strategy to accelerate axonal regeneration from neurons of the central nervous system.
en-copyright=
kn-copyright=

en-aut-name=KomatsuSeiji
en-aut-sei=Komatsu
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WakabayashiTaketoshi
en-aut-sei=Wakabayashi
en-aut-mei=Taketoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamadaKiyoshi
en-aut-sei=Yamada
en-aut-mei=Kiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsumotoKumiko
en-aut-sei=Matsumoto
en-aut-mei=Kumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KimataYoshihiro
en-aut-sei=Kimata
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KosakaJun
en-aut-sei=Kosaka
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg

affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Cytol & Histol

affil-num=3
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg

affil-num=4
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg

affil-num=5
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg

affil-num=6
en-affil=
kn-affil=Kansai Med Univ, Dept Anat & Cell Sci
en-keyword=graft
kn-keyword=graft
en-keyword=microsurgery
kn-keyword=microsurgery
en-keyword=optic nerve
kn-keyword=optic nerve
en-keyword=retinal ganglion cells
kn-keyword=retinal ganglion cells
en-keyword=Schwann cells
kn-keyword=Schwann cells
en-keyword=vascularized nerve
kn-keyword=vascularized nerve
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=260
end-page=267
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=19960801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=運動関連脳電位の年齢発達に伴う変化に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小川和則
kn-aut-sei=小川
kn-aut-mei=和則
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=399
end-page=454
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=本邦に於ける植物病害に關する文獻目錄（一九三四） 昭和九年度分
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=西門義一
kn-aut-sei=西門
kn-aut-mei=義一
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松本弘義
kn-aut-sei=松本
kn-aut-mei=弘義
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=345
end-page=397
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=本邦に於ける土壤肥料に關する文獻目錄 昭和九年度分
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=板野新夫
kn-aut-sei=板野
kn-aut-mei=新夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松浦章
kn-aut-sei=松浦
kn-aut-mei=章
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=317
end-page=344
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=邦產穀類の赤黴病に關する硏究（第一報） 麥類の赤黴病（黑點病）菌の小麥苗に對する病原性の分化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=西門義一
kn-aut-sei=西門
kn-aut-mei=義一
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松本弘義
kn-aut-sei=松本
kn-aut-mei=弘義
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山内己酉
kn-aut-sei=山内
kn-aut-mei=己酉
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=283
end-page=316
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=松材の靑變を起す「セラトストメラ･ピセエ｣菌に關する硏究 （木材の靑變に關する知見 第三報）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=西門義一
kn-aut-sei=西門
kn-aut-mei=義一
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山内己酉
kn-aut-sei=山内
kn-aut-mei=己酉
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=250
end-page=282
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=キンヒドロン電極法に依る自然状態に於ける土壤の水素イオン濃度測定法に就いて（第一報）水田土壤のPH測定
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=板野新夫
kn-aut-sei=板野
kn-aut-mei=新夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=辻康彦
kn-aut-sei=辻
kn-aut-mei=康彦
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=193
end-page=249
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=荳科植物の根瘤菌就いて（第五報） 根瘤菌の生育に及ぼす附帯要素として植物體汁液の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=板野新夫
kn-aut-sei=板野
kn-aut-mei=新夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松浦章
kn-aut-sei=松浦
kn-aut-mei=章
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=173
end-page=191
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Aerial-Earth Circuitの生物に及ぼす影響に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=板野新夫
kn-aut-sei=板野
kn-aut-mei=新夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=151
end-page=172
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=寒天に就て（續報）寒天の化學、物理的性質の研究及び寒天の品質の差異が微生物の生育に及ぼす影響に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=板野新夫
kn-aut-sei=板野
kn-aut-mei=新夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=辻康彦
kn-aut-sei=辻
kn-aut-mei=康彦
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=131
end-page=150
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=本邦土壤の沃素含量に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=板野新夫
kn-aut-sei=板野
kn-aut-mei=新夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=辻康彦
kn-aut-sei=辻
kn-aut-mei=康彦
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=112
end-page=130
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Azotobacterの生理的作用に及ぼす紫外線の研究（第二報）刺戟作用に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=板野新夫
kn-aut-sei=板野
kn-aut-mei=新夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松浦章
kn-aut-sei=松浦
kn-aut-mei=章
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=95
end-page=111
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=雜草種實の硏究 第一報 禾本科一
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=近藤萬太郎
kn-aut-sei=近藤
kn-aut-mei=萬太郎
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=笠原安夫
kn-aut-sei=笠原
kn-aut-mei=安夫
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=寺坂侑視
kn-aut-sei=寺坂
kn-aut-mei=侑視
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=85
end-page=93
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=藺フォトペリオヂズムに關する實驗的硏究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=笠原安夫
kn-aut-sei=笠原
kn-aut-mei=安夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=一色重夫
kn-aut-sei=一色
kn-aut-mei=重夫
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=73
end-page=84
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=豌豆、蠶豆のフォトペリオヂズムに關する實驗的硏究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=一色重夫
kn-aut-sei=一色
kn-aut-mei=重夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=笠原安夫
kn-aut-sei=笠原
kn-aut-mei=安夫
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=63
end-page=72
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=玄米を錐に入れ乾燥劑を添加したる貯藏試驗（二） 特に鹽化石灰の吸水狀況に就きて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=近藤萬太郎
kn-aut-sei=近藤
kn-aut-mei=萬太郎
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡村保
kn-aut-sei=岡村
kn-aut-mei=保
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=37
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=貯藏米殻の乾燥用として生石灰、鹽化石灰及び其他の價値比較
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=近藤萬太郎
kn-aut-sei=近藤
kn-aut-mei=萬太郎
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=一色重夫
kn-aut-sei=一色
kn-aut-mei=重夫
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=1
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=クロールピクリン燻蒸法に就きて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=春川忠吉
kn-aut-sei=春川
kn-aut-mei=忠吉
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=熊代三郎
kn-aut-sei=熊代
kn-aut-mei=三郎
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=109
end-page=115
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Screening of sperm velocity by fluid mechanical characteristics of a cyclo-olefin polymer microfluidic sperm-sorting device
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The microfluidic sperm-sorting (MFSS) device is a promising advancement for assisted reproductive technology. Previously, poly(dimethylsiloxiane) and quartz MFSS devices were developed and used for intracytoplasmic sperm injection. However, these disposable devices were not clinically suitable for assisted reproduction, so a cyclo-olefin polymer MFSS (COP-MFSS) device was developed. By micromachining, two microfluidic channels with different heights and widths (chip A: 0.3 x 0.5 mm; chip B: 0.1 x 0.6 mm) were prepared. Sorted sperm concentrations were similar in both microfluidic channels. Linear-velocity distribution using the microfluidic channel of chip B was higher than that of chip A. Using confocal fluorescence microscopy, it was found that the highest number of motile spermatozoa swam across the laminar flow at the bottom of the microfluidic channel. The time required to swim across the laminar flow was longer at the bottom and top of the microfluidic channels than in the middle because of the low fluid velocity. These results experimentally demonstrated that the width of microfluidic channels should be increased in the region of laminar flow from the semen inlet to the outlet for unsorted spermatozoa to selectively recover spermatozoa with high linear velocity.
en-copyright=
kn-copyright=

en-aut-name=MatsuuraKoji
en-aut-sei=Matsuura
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakenamiMami
en-aut-sei=Takenami
en-aut-mei=Mami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KurodaYuka
en-aut-sei=Kuroda
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HyakutakeToru
en-aut-sei=Hyakutake
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YanaseShinichiro
en-aut-sei=Yanase
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NaruseKeiji
en-aut-sei=Naruse
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University

affil-num=2
en-affil=
kn-affil=Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

affil-num=3
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University

affil-num=4
en-affil=
kn-affil=Faculty of Engineering, Yokohama National University

affil-num=5
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=6
en-affil=
kn-affil=Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
en-keyword=laminar flow
kn-keyword=laminar flow
en-keyword=linear velocity
kn-keyword=linear velocity
en-keyword=microfluidic sperm sorting
kn-keyword=microfluidic sperm sorting
en-keyword=motility
kn-keyword=motility
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=10
article-no=
start-page=1503
end-page=1528
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=2010
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of an Intelligent Chair Tool System Applying New Intelligent Pneumatic Actuators
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper develops an Intelligent Chair Tool (ICT) - a new chair-type human and machine interaction seating system powered by 36 intelligent pneumatic actuators. This tool can be used to facilitate investigation of chair shapes from spring and damping effects of seating and backrest surfaces. Each actuator used consists of five extensive elements of encoder, laser strip rod, pressure sensor, valves and PSoC microcontroller incorporated in a single device. By using the ICT, different shapes, spring and damping characteristics can be obtained to aid the design of chairs from the control inputs, i.e., position x, stiffness k(s) and viscous coefficient c. Several control algorithms are presented to realize the communication and control system, and to obtain all data in real-time. The control methodology presented contains an inner force loop and an outer position loop implemented using a unified control system. The specification, development design and experimental evaluation of the ICT control system and actuator used are presented and discussed.
en-copyright=
kn-copyright=

en-aut-name=FaudziAhmad 'Athif Mohd
en-aut-sei=Faudzi
en-aut-mei=Ahmad 'Athif Mohd
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SuzumoriKoichi
en-aut-sei=Suzumori
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WakimotoShuichi
en-aut-sei=Wakimoto
en-aut-mei=Shuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=3
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University
en-keyword=Intelligent Chair Tool
kn-keyword=Intelligent Chair Tool
en-keyword=seating system
kn-keyword=seating system
en-keyword=intelligent pneumatic actuator
kn-keyword=intelligent pneumatic actuator
en-keyword=physical human machine interaction
kn-keyword=physical human machine interaction
en-keyword=control application in mechatronics
kn-keyword=control application in mechatronics
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=10
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Necessity of Hospital Dentistry to Support Paticnts Undergoig Medical Treatment: Discussion based on a Case of Intensive lnterventions in Perioperative Management
kn-title=病院医療支援を目的とした口腔の管理学および専門診療分野の必要性―周術期医療への歯科的介入を例として―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SogaYoshihiko
en-aut-sei=Soga
en-aut-mei=Yoshihiko
kn-aut-name=曽我賢彦
kn-aut-sei=曽我
kn-aut-mei=賢彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院中央診療施設医療支援歯科治療部
en-keyword=hospital dentistry
kn-keyword=hospital dentistry
en-keyword=collaborative approaches
kn-keyword=collaborative approaches
en-keyword=perioperative management
kn-keyword=perioperative management
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=5
article-no=
start-page=455
end-page=465
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=1989
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Spontaneous Cell Mediated Cytotoxicity (SCMC) against Rat Skin Epidermal Cells - Comparison of Natural Cytotoxicity Cell (NC) with Killer Cell (KC) -
kn-title=ラット皮膚細胞に対する natural cytotoxicity (SCMC) の検討―natural cytotoxicity 細胞(NC)とキラー細胞(KC)との比較
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We have reported that normal rat spleen cells show spontaneous cell-mediated cytotoxicity (SCMC) against rat skin epidermal cells and that the cold target inhibition assay reveals that NC and immune spleen cells belonged to different cell populations. This time, we attempted to separate NC and KC from skin allografted immune spleen cells by using Percoll sedimentation and compare their cytotoxicity with that of normal spleen cells. Normal and skin grafted immune spleen cells were fractionated by 30-50% (grading by 5%) Percoll, and each fraction was used as an effector in the (51)Cr release cytotoxicity assay with the target of allogeneic or syngeneic rat tail epidermal cells. The results were; Fr. 40% as NC and Fr. 50% as KC population. Cytotoxicity of nonadherent cells to the plastic dish and nylon wool column showed approximately the same distribution. Cold target inhibition assay was then performed with each fraction, confirming the results in our previous report. Each fraction was treated with antiasialo GM1 serum and complement and drastic elimination of the cytotoxicity was seen only in Fr. 40%. In addition, cytotoxicity of Fr. 40% and Fr. 50% of 0, 1, 2, 3, 4, 7, 10, 13 and 16th days, following the syngeneic and allogeneic skin graft, was mointored in order to determine the kinetics of NC and KC activities.
en-copyright=
kn-copyright=

en-aut-name=FujimotoHideo
en-aut-sei=Fujimoto
en-aut-mei=Hideo
kn-aut-name=藤本英雄
kn-aut-sei=藤本
kn-aut-mei=英雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=First Department of Surgery, Okayama University Medical School
en-keyword=natural cytotoxicity cell
kn-keyword=natural cytotoxicity cell
en-keyword=killer cell
kn-keyword=killer cell
en-keyword=Percoll sedimentation
kn-keyword=Percoll sedimentation
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=241
end-page=247
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=200703
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Alternative Leader-Exon Usage in Mouse IGF-I mRNA Variants: Class 1 and Class 2 IGF-I mRNAs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The mouse IGF-I gene contains six exons, and exon 1 and exon 2 gene are considered to be leader exons. The regulatory mechanism of alternative usage of the leader exons is unclear in mice. The present study, was aimed at clarifying changes in class 1 (derived from exon 1) and class 2 (derived from exon 2) IGF-I mRNA expression in mice under various conditions. Both class 1 and class 2 IGF-I mRNAs were expressed in the mouse uterus, liver and kidney, and class 1 IGF-I mRNA was the major transcript in all organs studied. In the uterus, both class 1 and class 2 IGF-I mRNA expression changed markedly during the estrous cycle, with the highest level at proestrus, but in the liver and kidney there were no significant changes in IGF-I mRNA expression during the estrous cycle. Estrogen treatment increased both class 1 and class 2 IGF-I mRNA levels in the uterus of ovariectomized mice, but class 1 mRNA expression increased more in response to estrogen treatment than class 2 mRNA expression. These findings suggest that estrogen stimulates IGF-I gene expression in, uterine cells, and that a promoter involved in transcription of class 1 IGF-I mRNA is more responsive to estrogen. In conclusion, the present study revealed that two leader exons of mouse IGF-I gene are used in the uterus, liver and kidney. IGF-I mRNA levels of both classes changed during the estrous cycle in the uterus, but not in the liver or kidney. Estrogen increased IGF-I mRNA levels of both classes in the uterus.
en-copyright=
kn-copyright=

en-aut-name=OhtsukiTakashi
en-aut-sei=Ohtsuki
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OtsukiMariko
en-aut-sei=Otsuki
en-aut-mei=Mariko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MurakamiYousuke
en-aut-sei=Murakami
en-aut-mei=Yousuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HirataKensaku
en-aut-sei=Hirata
en-aut-mei=Kensaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakeuchiSakae
en-aut-sei=Takeuchi
en-aut-mei=Sakae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakahashiSumio
en-aut-sei=Takahashi
en-aut-mei=Sumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Biology, Faculty of Science, Okayama University

affil-num=2
en-affil=
kn-affil=Department of Biology, Faculty of Science, Okayama University

affil-num=3
en-affil=
kn-affil=Department of Biology, Faculty of Science, Okayama University

affil-num=4
en-affil=
kn-affil=Department of Biology, Faculty of Science, Okayama University

affil-num=5
en-affil=
kn-affil=Department of Biology, Faculty of Science, Okayama University

affil-num=6
en-affil=
kn-affil=Department of Biology, Faculty of Science, Okayama University
en-keyword=IGF-I
kn-keyword=IGF-I
en-keyword=leader exon
kn-keyword=leader exon
en-keyword=estrogen
kn-keyword=estrogen
en-keyword=uterus
kn-keyword=uterus
en-keyword=mouse
kn-keyword=mouse
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=6
article-no=
start-page=604
end-page=610
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=200706
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Unilateral Compound-Eye Removal on the Photoperiodic Responses of Nymphal Development in the Cricket Modicogryllus siamensis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The cricket, Modicogryllus siamensis, shows clear photoperiodic responses at 25 degrees C in nymphal development. Under long-day conditions (LD16:8), nymphs became adults about 50 days after hatching, while under short-day conditions (LD8:16) the duration of nymphal stage extended to more than 130 days. Under constant dark conditions, two developmental patterns were observed: about 60% of crickets became adults slightly slower than under the long-day conditions, and the rest at later than 100 days after hatching, like those under the short-day conditions. When the compound eye was unilaterally removed on the 2nd day of hatching, an increase of molting and an extension of the nymphal period were observed under the long-day conditions, while under the short-day conditions, some crickets developed faster and others slower than intact crickets. These results suggest that this cricket receives photoperiodic information through the compound eye, that a pair of the compound eyes is required for a complete photoperiodic response, and that interaction between bilateral circadian clocks may be also involved in the response.
en-copyright=
kn-copyright=

en-aut-name=SakamotoTomoaki
en-aut-sei=Sakamoto
en-aut-mei=Tomoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TomiokaKenji
en-aut-sei=Tomioka
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
en-keyword=cricket
kn-keyword=cricket
en-keyword=nymphal development
kn-keyword=nymphal development
en-keyword=photoperiodism
kn-keyword=photoperiodism
en-keyword=circadian clock
kn-keyword=circadian clock
en-keyword=compound eye
kn-keyword=compound eye
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080321
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=津島岡大遺跡 18　―第28次調査―　（自然科学系総合研究棟新営）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岩﨑志保
kn-aut-sei=岩﨑
kn-aut-mei=志保
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=白石純
kn-aut-sei=白石
kn-aut-mei=純
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=200009
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学埋蔵文化財調査研究センター報  第24号
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学埋蔵文化財調査研究センター
kn-aut-sei=岡山大学埋蔵文化財調査研究センター
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=245
end-page=265
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Gerhard Schmidt, "Einführung in die moderne sächsische Verfassungsgeschichte" (VII)
kn-title=ゲルハルト・シュミット「近代ザクセン国制史入門」（VII）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsuoNobushige
en-aut-sei=Matsuo
en-aut-mei=Nobushige
kn-aut-name=松尾展成
kn-aut-sei=松尾
kn-aut-mei=展成
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=231
end-page=244
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Haruki Kandatsu: Changes in Rural Landscapes after World War II in Japan
kn-title=神立春樹著 『戦後村落景観の変貌』
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakashigeSusumu
en-aut-sei=Takashige
en-aut-mei=Susumu
kn-aut-name=髙重進
kn-aut-sei=髙重
kn-aut-mei=進
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=215
end-page=230
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On "The Seto Ohashi Bridge and Regional Economic Environmental Problems" edited by Prof. C. Sakamoto and Prof. R. Nakamura
kn-title=坂本忠次・中村良平編著 『瀬戸大橋と地域経済・環境問題』 （山陽新聞社刊．pp．239．1992年3月25日）―瀬戸大橋架橋の社会経済的影響に関する包括的な総括への接近―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HashimotoRyoichi
en-aut-sei=Hashimoto
en-aut-mei=Ryoichi
kn-aut-name=橋本了一
kn-aut-sei=橋本
kn-aut-mei=了一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=四国学院大学
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=199
end-page=213
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Running Turbo BASIC on SIM
kn-title=Turbo BASICをSIM上で走らせる
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujimotoTakao
en-aut-sei=Fujimoto
en-aut-mei=Takao
kn-aut-name=藤本喬雄
kn-aut-sei=藤本
kn-aut-mei=喬雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=177
end-page=198
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Some Problems in Collections of Books and Materials at Okayama University Library
kn-title=岡山大学附属図書館における収書の在り方―岡山大学における人文社会科学系の研究条件の整備の一環として―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KandatsuHaruki
en-aut-sei=Kandatsu
en-aut-mei=Haruki
kn-aut-name=神立春樹
kn-aut-sei=神立
kn-aut-mei=春樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=161
end-page=176
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Corporate Social Reporting and the Analysis of the Quality of Earnings
kn-title=社会関連会計と利質分析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SatohMichimasa
en-aut-sei=Satoh
en-aut-mei=Michimasa
kn-aut-name=佐藤倫正
kn-aut-sei=佐藤
kn-aut-mei=倫正
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=139
end-page=160
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Part-Time Job Problems for Chinese Students under the Revised IC & RR Act (II)
kn-title=入管法改正に伴う中国人私費留学生のアルバイト問題（II）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkaMasumi
en-aut-sei=Oka
en-aut-mei=Masumi
kn-aut-name=岡益巳
kn-aut-sei=岡
kn-aut-mei=益巳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=109
end-page=138
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Regulation Modes of the Wage Formation in Japan, 1956-1989 (I)
kn-title=戦後日本における賃金決定のレギュラシオン様式（I）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ShimizuKoichi
en-aut-sei=Shimizu
en-aut-mei=Koichi
kn-aut-name=清水耕一
kn-aut-sei=清水
kn-aut-mei=耕一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=81
end-page=107
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Seattle Labor Movement after the General Strike
kn-title=ゼネラル・ストライキ後のシアトル労働運動
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KurokawaKatsutoshi
en-aut-sei=Kurokawa
en-aut-mei=Katsutoshi
kn-aut-name=黒川勝利
kn-aut-sei=黒川
kn-aut-mei=勝利
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=49
end-page=80
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Die Stadtverfassungen vor demErscheinen der "Allgemeinen Städteordnung" von 1832 in Sachsen (I)
kn-title=市民的改革以前のザクセンにおける都市制度（I）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsuoNobushige
en-aut-sei=Matsuo
en-aut-mei=Nobushige
kn-aut-name=松尾展成
kn-aut-sei=松尾
kn-aut-mei=展成
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=25
end-page=48
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the Regional Input-Output Analysis of the Sight-Seeing Consumption
kn-title=観光消費の地域産業連関分析について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujimotoToshimi
en-aut-sei=Fujimoto
en-aut-mei=Toshimi
kn-aut-name=藤本利躬
kn-aut-sei=藤本
kn-aut-mei=利躬
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=4
article-no=
start-page=1
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Characteristic and Transfiguration of Local Finance in Japan
kn-title=日本の地方財政の特質と変貌
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SakamotoChuji
en-aut-sei=Sakamoto
en-aut-mei=Chuji
kn-aut-name=坂本忠次
kn-aut-sei=坂本
kn-aut-mei=忠次
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=133
end-page=152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19921125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Industrial Structure and Cooperative Society in the Okayama Prefecture since the Period of High Economic Growth
kn-title=高度経済成長期以後の岡山県の産業構造と生活協同組合
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ShimonoKatsumi
en-aut-sei=Shimono
en-aut-mei=Katsumi
kn-aut-name=下野克巳
kn-aut-sei=下野
kn-aut-mei=克巳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=115
end-page=132
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19921125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Public Finance in the Period of High Economic Growth Rates
kn-title=高経済成長期の財政（II）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HabuYoshito
en-aut-sei=Habu
en-aut-mei=Yoshito
kn-aut-name=土生芳人
kn-aut-sei=土生
kn-aut-mei=芳人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=91
end-page=113
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19921125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=New Business Development and Orgavizational Culture - An Analysis of Japanese Firms -
kn-title=日本企業の新事業開発と組織文化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamadaKōzō
en-aut-sei=Yamada
en-aut-mei=Kōzō
kn-aut-name=山田幸三
kn-aut-sei=山田
kn-aut-mei=幸三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=61
end-page=90
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19921125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Part-Time Job Problems for Chinese Students under the Revised IC & RR Act (I)
kn-title=入管法改正に伴う中国人私費留学生のアルバイト問題（I）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkaMasumi
en-aut-sei=Oka
en-aut-mei=Masumi
kn-aut-name=岡益巳
kn-aut-sei=岡
kn-aut-mei=益巳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=31
end-page=59
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19921125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Toward a Theory Building in Business History: the Case of The McLaughlin Motor Car Company
kn-title=経営史学の理論化に向けて―マクローリン自動車会社の事例を参考にして―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=EnomotoSatoru
en-aut-sei=Enomoto
en-aut-mei=Satoru
kn-aut-name=榎本悟
kn-aut-sei=榎本
kn-aut-mei=悟
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=3
article-no=
start-page=1
end-page=29
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19921125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Lural Life in Kanagawa Prefecture in the Late Meiji Era (I)
kn-title=明治後期の神奈川県一農村における村民生活―神奈川県都筑郡中川村の「村是調査書］による検討―（I）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KandatsuHaruki
en-aut-sei=Kandatsu
en-aut-mei=Haruki
kn-aut-name=神立春樹
kn-aut-sei=神立
kn-aut-mei=春樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=215
end-page=224
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Shozo Takayose, "The Management of Extra-departmental Bodies in Local Governments, 1991"
kn-title=高寄昇三著 『外郭団体の経営』 1991年
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SakamotoChuji
en-aut-sei=Sakamoto
en-aut-mei=Chuji
kn-aut-name=坂本忠次
kn-aut-sei=坂本
kn-aut-mei=忠次
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=201
end-page=213
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Simple Method to Incorporate a Japanese FEP into English Word Processors
kn-title=英文ワードプロセッサに日本語機能を付加する簡便法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujimotoTakao
en-aut-sei=Fujimoto
en-aut-mei=Takao
kn-aut-name=藤本喬雄
kn-aut-sei=藤本
kn-aut-mei=喬雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=163
end-page=199
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Gerhard Schmidt, "Einführung in die moderne sächsische Verfassungsgeschichte" (VI)
kn-title=ゲルハルト・シュミット「近代ザクセン国制史入門」（VI）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsuoNobushige
en-aut-sei=Matsuo
en-aut-mei=Nobushige
kn-aut-name=松尾展成
kn-aut-sei=松尾
kn-aut-mei=展成
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=157
end-page=162
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Bank of Japan Operations, 1955-1964: Question Raising - Regulation of International Capital Movement and the 'low Bank Rate -
kn-title=昭和30年代の日銀金融政策：問題設定―内外資本移動規制と「低い公定歩合」政策―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IchinoseAtsushi
en-aut-sei=Ichinose
en-aut-mei=Atsushi
kn-aut-name=一ノ瀬篤
kn-aut-sei=一ノ瀬
kn-aut-mei=篤
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=97
end-page=156
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Patterns and Processes of Japanese Urban Population Change
kn-title=都市の人ロ成長パターンの類型化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakamuraRyōhei
en-aut-sei=Nakamura
en-aut-mei=Ryōhei
kn-aut-name=中村良平
kn-aut-sei=中村
kn-aut-mei=良平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=61
end-page=95
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Human Resource Management in Foreign Companies in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=DebrouxPhilippe
en-aut-sei=Debroux
en-aut-mei=Philippe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=51
end-page=60
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparison of the Concept of Corporation between U. S. A. and Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WakabayashiMasashi
en-aut-sei=Wakabayashi
en-aut-mei=Masashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Faculty of Economics, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=25
end-page=49
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Development of Power Looms Production in the Meiji Era
kn-title=明治期における力織機生産の展開―最近の研究成果にもとづく一整理―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KandatsuHaruki
en-aut-sei=Kandatsu
en-aut-mei=Haruki
kn-aut-name=神立春樹
kn-aut-sei=神立
kn-aut-mei=春樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=1
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Public Finance in the Period of High Economic Growth Rates (I)
kn-title=高経済成長期の財政（I）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HabuYoshito
en-aut-sei=Habu
en-aut-mei=Yoshito
kn-aut-name=土生芳人
kn-aut-sei=土生
kn-aut-mei=芳人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=137
end-page=170
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920526
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Gerhard Schmidt,
kn-title=ゲルハルト・シュミット「近代ザクセン国制史入門」（V）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsuoNobushige
en-aut-sei=Matsuo
en-aut-mei=Nobushige
kn-aut-name=松尾展成
kn-aut-sei=松尾
kn-aut-mei=展成
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=117
end-page=122
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920526
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Labour Value of an Easily Duplicatable Commodity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujimotoTakao
en-aut-sei=Fujimoto
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=RanadeRavindra R.
en-aut-sei=Ranade
en-aut-mei=Ravindra R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=Department of Economics, University of Kagawa
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=83
end-page=115
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920526
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=New Business Development and Management System - An Analysis of Japanese Firms -
kn-title=明治期の岡山市における商工業の展開
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamadaKōzō
en-aut-sei=Yamada
en-aut-mei=Kōzō
kn-aut-name=神立春樹
kn-aut-sei=神立
kn-aut-mei=春樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=61
end-page=82
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920526
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=New Business Development and Management System - An Analysis of Japanese Firms -
kn-title=新事業開発の経営管理システム
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamadaKōzō
en-aut-sei=Yamada
en-aut-mei=Kōzō
kn-aut-name=山田幸三
kn-aut-sei=山田
kn-aut-mei=幸三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=37
end-page=59
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920526
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Reconsideration: Competition, Rivalry and Firm System - A Case of Semiconductor Industry -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakemuraShōsuke
en-aut-sei=Takemura
en-aut-mei=Shōsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920526
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=High Economic Growth Rate of Post-War Capitalism
kn-title=戦後資本主義の高経済成長
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HabuYoshito
en-aut-sei=Habu
en-aut-mei=Yoshito
kn-aut-name=土生芳人
kn-aut-sei=土生
kn-aut-mei=芳人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=96
end-page=103
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=195901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Case of Gastric Polip
kn-title=胃ポリープの1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We examine patients seeking for spa treatment about erythrocyte sedimentation rate, Takata's reaction, blood picture, gastric juice, urinalysis and so on on their admittion and then repeat these tests once weekly to investigate the reaction of bathing in radioactive hot spring. A 65-year-old patient showed achylia gastrica every time in the test, but he complained no gastric symptom. On x-ray examination we found gastric polyp and verified this on operation.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoKinshi
en-aut-sei=Matsumoto
en-aut-mei=Kinshi
kn-aut-name=松本欣之
kn-aut-sei=松本
kn-aut-mei=欣之
aut-affil-num=1
ORCID=

en-aut-name=WakutaniTohaku
en-aut-sei=Wakutani
en-aut-mei=Tohaku
kn-aut-name=涌谷卓伯
kn-aut-sei=涌谷
kn-aut-mei=卓伯
aut-affil-num=2
ORCID=

en-aut-name=IzumiTomokuni
en-aut-sei=Izumi
en-aut-mei=Tomokuni
kn-aut-name=泉友圀
kn-aut-sei=泉
kn-aut-mei=友圀
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学温泉研究所内科

affil-num=2
en-affil=
kn-affil=岡山大学温泉研究所内科

affil-num=3
en-affil=
kn-affil=岡山大学温泉研究所外科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=87
end-page=95
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=195901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Case of Agammaglobulinemia
kn-title=Agammaglobulinemiaの1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A case of agammaglobulinemia, probably of the secondary type, is reported in adult female (45-year-old) with tumor of the mediastinum. The authors described the bibliographical consideration and arose the attention of agammaglobulinemia. Reports on agammaglobulinemia may increase in practise if electrophoresis of the
serum protein-fraction is used as a routine examination method.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoKinshi
en-aut-sei=Matsumoto
en-aut-mei=Kinshi
kn-aut-name=松本欣之
kn-aut-sei=松本
kn-aut-mei=欣之
aut-affil-num=1
ORCID=

en-aut-name=WakutaniTohaku
en-aut-sei=Wakutani
en-aut-mei=Tohaku
kn-aut-name=涌谷卓伯
kn-aut-sei=涌谷
kn-aut-mei=卓伯
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学温泉研究所内科

affil-num=2
en-affil=
kn-affil=岡山大学温泉研究所内科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=80
end-page=86
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=195901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=General Survey of the Spa Treatment at Misasa Spa, Tottori Prefecture
kn-title=三朝温泉に於ける湯治概況調査
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Misasa Hot Spring is one of the most famous radioactiye hot springs in Japan. A general survey of the spa treatment at Misasa Spa was carried out in Feburary, 1957. The informations we have gathered may be summarized as follows: 1). The number of the spa visitors seeking for curative treatment was almost equally divided between men and women and the majority of the spa visitors was over 50 years old. 2). 65% of the spa visitors came to this hot spring with the specific purpose of balneotherapy. 19.3% came for rest, 13.3% for the purpose of after-care. 3). Those who visited Misasa Spa for the first time were 44.7%, the rest being those who visited this spa over 2 times. 18.3% of them had consultation with or were under the direction of a physician. 4). The length of time they stay at this spa for curative treatment: 41.6% of the spa visitors stay for 8～14 days, 17.9% of them 15～20 days and 31% of them over three weeks. 5). About 74% of the spa visitors bathe 3 to 5 times a day for curative treatment, and 82% of them drink hot spring water. 6). Symptoms of bathing reaction such as generalised fatigue, constipation, loss of
appetite, joint pain, abdominal pain and so on were observed in 50% of the spa visitors.
en-copyright=
kn-copyright=

en-aut-name=WakutaniTohaku
en-aut-sei=Wakutani
en-aut-mei=Tohaku
kn-aut-name=涌谷卓伯
kn-aut-sei=涌谷
kn-aut-mei=卓伯
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoKinshi
en-aut-sei=Matsumoto
en-aut-mei=Kinshi
kn-aut-name=松本欣之
kn-aut-sei=松本
kn-aut-mei=欣之
aut-affil-num=2
ORCID=

en-aut-name=YamamotoYasuhisa
en-aut-sei=Yamamoto
en-aut-mei=Yasuhisa
kn-aut-name=山本泰久
kn-aut-sei=山本
kn-aut-mei=泰久
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学温泉研究所内科

affil-num=2
en-affil=
kn-affil=岡山大学温泉研究所内科

affil-num=3
en-affil=
kn-affil=岡山大学温泉研究所内科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=54
end-page=79
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=195901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Paper-analysis in the Field of Balneology. (3) The Changes of the Serum Protein Fractions and Lipoprotein Fractions Following the Bathing in Radioactive Hot Spring
kn-title=温泉医学領域に於ける嘘紙分析法の研究　(III)．温泉入浴と血清蛋白分屑の変動　（付，リポ蛋白）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I. Some fundamental conditions and procedures on filter-paper electrophoresis were investigated. The electrophoretic apparatus of Natsume Seisakusho and Toyo No. 51 filter-paper were used. Electrophoresis was carried out under the current of 0.25 mA/cm. in 300 Volt during 5 hours, using veronal buffer pH 8.6 (μ=0.05). In
measuring of serum protein fractions, the adequate volume of the materials loaded is in the range of 0.005～0.01 ml. and in the case of lipoprotein, 0.02 ml. of serum is used. Paper-strip was stained with bromophenol blue or sudan black B, then making it transparent with heat-solved paraffin and photometered by Nataume's
densitometer. The reproducibility of the above-mentioned method with a confidence of 99% was as follows: 
Serum protein fractions 
Albumin 53.4±1.8% 
α(1)-Globulin 3.3±0.3 
α(2)-Globulin 6.0±0.5 
β-Globulin 12.2±0.7 
γ-Globulin 25.1±1.1 
Serum lipoprotein fractions
α 20.6±2.6% 
β+γ 79.4±2.6 
II. Changes in serum protein fractions and lipoprotein fractions following the radioactive hot spring bathing were as follows: 1). In rabbits, the albumin-fraction of serum protein increased after a series of baths in radioactive hot spring, and the β- and γ-globulin-fractions decreased. 2). By cholesterol-feeding, the albumin-fraction of serum protein of rabbits decreased and the β- and γ-globulin-fractions increased significantly but when a series of baths was carried out in cholesterol-fed rabbits the decrease in the albumin-fraction was slighter than the former. 3). α-globulin-fraction of serum lipoprotein increased after single bathing in
radioactive hot spring and (β+γ) -globulin-fractions showed an inverse change, but the changes of lipoprotein-fractions following a series of baths were not remarkable. 4). By cholesterol-feeding, the ratio of lipoprotein-fractions (β+γ/α) increased, but the ratio tended to decrease following a series of baths in radioactive hot spring.
en-copyright=
kn-copyright=

en-aut-name=IshibashiMaruo
en-aut-sei=Ishibashi
en-aut-mei=Maruo
kn-aut-name=石橋丸応
kn-aut-sei=石橋
kn-aut-mei=丸応
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学温泉研究所
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=29
end-page=53
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=195901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Paper-analysis in the Field of Balneology. (II) 1. A New Method for the Determination of Cobalt in Blood. 2. Effects of Radioactive Thermal Bathing and Internal Use of Vitriol Water upon Cobalt Levels in Blood.
kn-title=温泉医学領域に於ける濾紙分析法の研究　(II). 濾紙-Chromatographyによる血液コバルトに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. A new method for the determination of cobalt in blood. The author proposed a new method for the determination of cobalt in blood by means of paper-chromatography. The procedure is follows. In a Kjeldahl colben, 5 m!. of blood is taken, and turned into wet ash with 3 ml. of HNO(3), 0.5 ml. of H(2)SO(4) and 1.5 ml. of HClO(4) and the ash aqueus solution is then neutralized with ammonium hydroxid, the neutralization being indicated by the development of color of 0.1% of p-nitrophenol (one drop) added to the solution. After addition of 2 ml. of 40% ammonium citrate, 0.5 ml. of 20% Na(2)S(2)O(3), 3～5 drops of H(2)O(2) and 1 ml. of o-nitrosoresorcine monomethyl ether (hereafter N.R.M.E.), the mixture is left for at least 15 minutes and the aqueus solution is taken in a stoppered test tube (inside diameter: 1.3 cm., hight: 16.5 cm.). The mixture is shaken with 2 ml. of carbon tetrachloride. Carbon tetrachloride is shaken with 5 ml. of 20% Na(2)CO(3) solution. Then the excess of N.R.M.E. is removed and carbon tetrachloride is concentrated on water bath to 0.3～0.5 ml. and all CCl(4) is used for a determination sample. The sample is placed on the paper (Toyo-filter paper No. 50 or 51A) in a thin line at a distance of 3 cm. from the edge, and the spot is developed with a mixture of 20 ml. of CCl(4) and 1 ml. of 90% ethylalcohoI. After development for 30～40 min., an orange-colored linear spot appears at a distance of 9～10 em. from the origin point. Spot intensity is measured at 460 mμ with Natsume's densitometer and quantitative estimation is made comparing with the standard graph. 2. Effects of radioactive thermal spring bathing and internal use of vitriol water upon cobalt levels in blood. As the author's method above-mentioned is able to determine the cobalt level in a small amount of blood, it is very convenient in investigating cobalt metabolism in the field of balneology. The author examined the changes of cobalt levels in blood after radioactive thermal bathing as well as after internal use of acid vitriol water. a. By the author's method cobalt in normal human blood was 0.4～3.6γ/100ml. in man (average: 1.6±0.4γ/100ml.) and 0.2～2.2γ/100ml. in woman (average: 0.7±0.3γ/100ml.). b. The cobalt levels in blood were measured by the author's method before and 5, 30, 60 minutes after the radioactive thermal single bathing, and before and
1, 2, 3, 4 weeks after a series of radioactive thermal baths (Rn-content: 10～30 Mache, 42～3°C., for 10 minutes). The cobalt levels in the blood of healthy subjects showed no significant change after the thermal single bathing, but those of patients with rheumatoid arthritis showed a slight increase on 3rd or 7th day and a fall on 2nd week of a series of radioactive thermal baths and then tended to return to the initial levels during the 3rd and 4th weeks of spa treatment. c. Thirty ml. of Yanahara mineral water (an acid vitriol water, pH: 2.2) was diluted with plain water to 200 ml. (Co(++)content: ca.3γ) and administered to healthy fasting subjects orally. Blood samples were taken from the cubital vein before and 1, 3, 6 hours after the intake of the vitriol water. The cobalt levels in the blood showed an increase of 14% of the initial levels at 1 and 3 hours and a decrease of 22% at 6 hours after the drinking of Yanahara mineral water.
en-copyright=
kn-copyright=

en-aut-name=IshibashiMaruo
en-aut-sei=Ishibashi
en-aut-mei=Maruo
kn-aut-name=石橋丸応
kn-aut-sei=石橋
kn-aut-mei=丸応
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学温泉研究所
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=1
end-page=28
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=195901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical and Experimental Studies of Therapeutic Effects of Radioactive Thermal Bath on Peripheric Disorders of Circulation Part 4 Therapeutic Effects of Radioactive Thermal Bath on Blood pressure
kn-title=放射能泉浴の末梢循環器病に及ぼす効果に関する臨床的並に実験的研究　第4編　三朝温泉入浴の高血圧症及び動脈硬化症に及ぼす影響に関する臨床的並びに統計的観察（血圧の変動を中心として）　付　全編の総括と結論
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1) The effects of a single bath in the radioactive hot spring on the blood pressure and the pulse rate. The author observed the changes of the blood pressure and the pulse rate of subjects bathing for 20 minutes, 39°± 1°C, in temperature, in the radioactive hot spring in Misasa. It may be summerized as follows (Table 2, Fig. 1). a. In the hypertensive group (maximal blood pressure······181 mm. Hg. and over), the maximal blood pressure had decreased immediately after bathing, and remained at this level even 2 hours after bathing. The minimal blood pressure reacted in the same manner as the maximal blood pressure. b. The moderate hypertensive group (maximal blood pressure······180-161 mm. Hg.). In a few instances, the maximal blood pressure had increased immediately after bathing, but decreased within 30-90 minutes after bathing. Changes in the minimal blood pressure were not so remarkable. c. In the normal group (maximal blood pressure······160～101 mm. Hg.), the maximal blood pressure had lowered within 30-90 minutes after the radioactive hot spring bathing. The minimal blood pressure showed no significant changes. b. The pulse rate had increased immediately after bathing in all groups, but within 30 minntes had returned to the initial rate and there were no further changes for 2 hours (Table 2, Fig. 2). 2) The effects of a radioactive vapour bath on the blood pressure and the pulse rate. After a bathing in vapour bath (10～15 minutes), the maximal and the minimal
blood pressure showed mild decrease for 2 hours. The changes of the pulse rate and the pulse amplitude were not so remarkable (Table 3, Fig. 3). 3) The effects of a series of baths in the radioactive spring on the blood pressure. The author observed the changes in the blood pressure of the subjects bathed 2 or 3 times daily in the radioactive hot spring in Misasa, at a temperature of 42～43°C., 5～10 minutes. The blood pressure of subjects was measured once a day (at 7 a.m.) for the first week, and subsequently once weekly for two additional weeks. Subjects with an initial maximal blood pressure over 160 mm. Hg. showed a fall on the second day of the spa treatment followed by a temporary rise on the 3rd or 4th day, after which the pressure fell to the 2nd day level again, and then remained fairly constant to the end of the observation period. Subjects with an initial blood
pressure under 159 mm. Hg. also showed a fall in the course of the spa treatment, but the degree of the fall was slighter than that of the former (Table 4, Fig. 4). This tendency was also observed on the out-patients (Table 5, Fig. 5). The changes of the blood pressure and pulse rate of subjects after a bath for 20 minutes, in water 39±1°C. in temperature, on the first day of the spa therapy were compared with those occuring on the 6th or 7th day, and it was observed that the patterns of the changes in blood pressure following bathing on the two days were significantly different (i.e. on the latter, so called "the initial blood pressure increase following the bathing" was not observed) (Table 6,7,8, Fig.6,7,8,9,). 4) The remote investigation on the spa visitors with hypertension and/or arteriosclerosis. The author investigated the course of patients with hypertension and/or arteriosclerosis who received the spa treatment at Misasa after returned to home. The incidence of subjects who answered as being good was 86%, and it was observed the fall of the maximal and the minimal blood pressure, especially the fall was remakable in subjects who stayed at spa about 4 weeks (Table 10, 11, 12, 13, 14, 15, Fig. 10). 5) The incidence of hypertension among the residents in the spa resort and those residing in other places. The author measured the blood presssre of the out-patients of his institute over
41 years of age from June, 1956 to May, 1957. The incidence of patients with the maximal blood pressure over 160 mm. Hg. was 16.4% in spa resort, and 25.7% in places where there are no hot springs. Using x(2)-test, the difference between the two was recognised as being significant (Table 16, 18). 6) Comparison of the mortality rate of patients with hypertension between residents in the spa resort and those residing in other places. The author examined the mortality rate of persons with hypertension in the area under the jurisdiction of the Kurayoshi Sanitary Institute, Tottori prefecture, from 1954 to 1956. The rate of mortality in the spa resort was 17.5% as compared to 21.4% in other places (Table17).
en-copyright=
kn-copyright=

en-aut-name=MatsumotoKinshi
en-aut-sei=Matsumoto
en-aut-mei=Kinshi
kn-aut-name=松本欣之
kn-aut-sei=松本
kn-aut-mei=欣之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学温泉研究所
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=195901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学温泉研究所報告第24号正誤表
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Institute for Thermal Spring Research, Okayama University
en-aut-sei=Institute for Thermal Spring Research, Okayama University
en-aut-mei=
kn-aut-name=岡山大学温泉研究所
kn-aut-sei=岡山大学温泉研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=195901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙・目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学温泉研究所
kn-aut-sei=岡山大学温泉研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=441
end-page=416
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20067
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Control strategy and site selection of a shunt active filter for damping of harmonic propagation in power distribution systems
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AkagiHirofumi
en-aut-sei=Akagi
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=25
end-page=35
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An application of certain multiplicities of C∞ map germs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AndoYoshifumi
en-aut-sei=Ando
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Yamaguchi University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=53
end-page=71
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Subgroup SU(8)/Z2 of compact simple Lie group E7 and non-compact simple Lie group E{7(7)} of type E7
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YokotaIchiro
en-aut-sei=Yokota
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Shinshu University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=6
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Note on groups with isomorphic group algebras
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FurukawaTôru
en-aut-sei=Furukawa
en-aut-mei=Tôru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=21
end-page=23
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=On a theorem of M. S. Putcha and A. Yaqub
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KomatsuHiroaki
en-aut-sei=Komatsu
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Osaka City University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=15
end-page=19
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Some remarks on bisimple rings
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HiranoYasuyuki
en-aut-sei=Hirano
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TominagaHisao
en-aut-sei=Tominaga
en-aut-mei=Hisao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=73
end-page=97
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Surgery obstruction of twisted products
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YoshidaTomoyoshi
en-aut-sei=Yoshida
en-aut-mei=Tomoyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=7
end-page=13
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Some polynomial identities and commutativity of s-unital rings
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HiranoYasuyuki
en-aut-sei=Hirano
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KobayashiYuji
en-aut-sei=Kobayashi
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TominagaHisao
en-aut-sei=Tominaga
en-aut-mei=Hisao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Tokushima University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=45
end-page=51
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=On J-groups of S^l(RP(t-l)/RP(n-l))
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KônoSusumu
en-aut-sei=Kôno
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TamamuraAkie
en-aut-sei=Tamamura
en-aut-mei=Akie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University of Science
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=37
end-page=44
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=On the iterated Samelson product
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KachiHideyuki
en-aut-sei=Kachi
en-aut-mei=Hideyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Shinshu University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=137
end-page=152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A certain type of commutative Hopf Galois extensions and their groups
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakajimaAtsushi
en-aut-sei=Nakajima
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=167
end-page=178
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Notes on stable equivariant maps
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IzumiyaSyuichi
en-aut-sei=Izumiya
en-aut-mei=Syuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Nara Women's University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=99
end-page=109
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=On right p.p. rings
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HiranoYasuyuki
en-aut-sei=Hirano
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HonganMotoshi
en-aut-sei=Hongan
en-aut-mei=Motoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ÔhoriMasayuki
en-aut-sei=Ôhori
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Tsuyama College of Technology

affil-num=3
en-affil=
kn-affil=Shinshu University
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=2
article-no=
start-page=133
end-page=136
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=On the equational definability of addition in rings
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KomatsuHiroaki
en-aut-sei=Komatsu
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Osaka City University
END