start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=22
article-no=
start-page=e038137
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241119
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Eight-Year Outcomes of Cardiosphere-Derived Cells in Single Ventricle Congenital Heart Disease
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Cardiosphere‐derived cell (CDC) infusion was associated with better clinical outcomes at 2 years in patients with single ventricle heart disease. The current study investigates time‐to‐event outcomes at 8 years.
Methods and Results: This cohort enrolled patients with single ventricles who underwent stage 2 or stage 3 palliation from January 2011 to January 2015 at 8 centers in Japan. The primary outcomes were time‐dependent CDC treatment effects on death and late complications during 8 years of follow‐up, assessed by restricted mean survival time. Among 93 patients enrolled (mean age, 2.3±1.3 years; 56% men), 40 received CDC infusion. Overall survival for CDC‐treated versus control patients did not differ at 8 years (hazard ratio [HR], 0.60 [95% CI, 0.21–1.77]; P=0.35). Treatment effect had nonproportional hazards for death favoring CDCs at 4 years (restricted mean survival time difference +0.33 years [95% CI, 0.01–0.66]; P=0.043). In patients with heart failure with reduced ejection fraction, CDC treatment effect on survival was greater over 8 years (restricted mean survival time difference +1.58 years [95% CI, 0.05–3.12]; P=0.043). Compared with control participants, CDC‐treated patients showed lower incidences of late failure (HR, 0.45 [95% CI, 0.21–0.93]; P=0.027) and adverse events (subdistribution HR, 0.50 [95% CI, 0.27–0.94]; P=0.036) at 8 years.
Conclusions: By 8 years, CDC infusion was associated with lower hazards of late failure and adverse events in single ventricle heart disease. CDC treatment effect on survival was notable by 4 years and showed a durable clinical benefit in patients with heart failure with reduced ejection fraction over 8 years.
Registration: URL: https://www.clinicaltrials.gov; Unique identifiers: NCT01273857 and NCT01829750.
en-copyright=
kn-copyright=
en-aut-name=HiraiKenta
en-aut-sei=Hirai
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SawadaRyusuke
en-aut-sei=Sawada
en-aut-mei=Ryusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=HayashiTomohiro
en-aut-sei=Hayashi
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=ArakiToru
en-aut-sei=Araki
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NakagawaNaomi
en-aut-sei=Nakagawa
en-aut-mei=Naomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KondoMaiko
en-aut-sei=Kondo
en-aut-mei=Maiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=YasudaKenji
en-aut-sei=Yasuda
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=HirataTakuya
en-aut-sei=Hirata
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=SatoTomoyuki
en-aut-sei=Sato
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=NakatsukaYuki
en-aut-sei=Nakatsuka
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=YoshidaMichihiro
en-aut-sei=Yoshida
en-aut-mei=Michihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=KasaharaShingo
en-aut-sei=Kasahara
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
en-aut-name=BabaKenji
en-aut-sei=Baba
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=
en-aut-name=OhHidemasa
en-aut-sei=Oh
en-aut-mei=Hidemasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=
en-aut-name=the TICAP/PERSEUS Study Group
en-aut-sei=the TICAP/PERSEUS Study Group
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=
affil-num=1
en-affil=Department of Pediatrics Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Pharmacology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Pediatrics Kurashiki Central Hospital
kn-affil=
affil-num=4
en-affil=Department of Pediatrics National Hospital Organization Fukuyama Medical Center
kn-affil=
affil-num=5
en-affil=Department of Pediatric Cardiology Hiroshima City Hiroshima Citizens Hospital
kn-affil=
affil-num=6
en-affil=Department of Pediatrics Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
affil-num=7
en-affil=Department of Pediatrics Shimane University Faculty of Medicine
kn-affil=
affil-num=8
en-affil=Department of Pediatrics Kyoto University Graduate School of Medicine
kn-affil=
affil-num=9
en-affil=Department of Pediatrics Jichi Medical University
kn-affil=
affil-num=10
en-affil=Department of Data Science, Center for Innovative Clinical Medicine Okayama University Hospital
kn-affil=
affil-num=11
en-affil=Department of Data Science, Center for Innovative Clinical Medicine Okayama University Hospital
kn-affil=
affil-num=12
en-affil=Department of Cardiovascular Surgery Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
affil-num=13
en-affil=Department of Pediatrics Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
affil-num=14
en-affil=Department of Regenerative Medicine, Center for Innovative Clinical Medicine Okayama University Hospital
kn-affil=
affil-num=15
en-affil=
kn-affil=
en-keyword=cardiosphere
kn-keyword=cardiosphere
en-keyword=heart failure
kn-keyword=heart failure
en-keyword=restricted mean survival time
kn-keyword=restricted mean survival time
en-keyword=single ventricle
kn-keyword=single ventricle
en-keyword=survival
kn-keyword=survival
END
start-ver=1.4
cd-journal=joma
no-vol=67
cd-vols=
no-issue=6
article-no=
start-page=645
end-page=651
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230810
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Accuracy of ultrasound vs. Fourier-domain optic biometry for measuring preoperative axial length in cases of rhegmatogenous retinal detachment
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose To identify a method for accurately measuring preoperative axial length (AL) in cases of rhegmatogenous retinal detachment (RRD).
Study design Retrospective study.
Methods This retrospective study included 83 eyes of 83 patients who underwent vitrectomy for RRD and had both preoperative and postoperative data for AL. Preoperative AL measurements for the affected eye were obtained using ultrasound (aUS-AL) and compared with those for affected and fellow eyes measured using optical biometry (aOB-AL and fOB-AL, respectively). Absolute differences between preoperative aUS-AL, aOB-AL, or fOB-AL measurements and postoperative AL (aPost-AL) were examined.
Results In the 41 eyes without macular detachment, the absolute difference between aOB-AL and aPost-AL (0.06±0.07 mm) was significantly smaller than between aUS-AL and aPost-AL (0.21±0.18 mm) and that between fOB-AL and aPost-AL (0.29±0.35 mm) (P = 0.017 and P < 0.001, respectively). In the 42 eyes with macular detachment, the absolute difference between aOB-AL and aPost-AL (1.22±2.40 mm) was significantly larger than between aUS-AL and aPost-AL (0.24±0.24 mm) and between fOB-AL and aPost-AL (0.35±0.49 mm) (P = 0.006, P = 0.016, respectively).
Conclusion The current findings suggest that aOB-AL is more accurate than aUS-AL or fOB-AL in cases of RRD without macular detachment, while aUS-AL or fOB-AL is more accurate than aOB-AL in cases with macular detachment.
en-copyright=
kn-copyright=
en-aut-name=KimuraShuhei
en-aut-sei=Kimura
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=HosokawaMio Morizane
en-aut-sei=Hosokawa
en-aut-mei=Mio Morizane
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=ShiodeYusuke
en-aut-sei=Shiode
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MatobaRyo
en-aut-sei=Matoba
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KanzakiYuki
en-aut-sei=Kanzaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=GotoYasuhito
en-aut-sei=Goto
en-aut-mei=Yasuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=KanenagaKeisuke
en-aut-sei=Kanenaga
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=SuzukiEtsuji
en-aut-sei=Suzuki
en-aut-mei=Etsuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=MorizaneYuki
en-aut-sei=Morizane
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
affil-num=1
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=5
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=6
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=7
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=8
en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Axial length
kn-keyword=Axial length
en-keyword=Rhegmatogenous retinal detachment
kn-keyword=Rhegmatogenous retinal detachment
en-keyword=Macular detachment
kn-keyword=Macular detachment
en-keyword=Fourier-domain optic biometry
kn-keyword=Fourier-domain optic biometry
en-keyword=Ultrasound
kn-keyword=Ultrasound
END
start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=4
article-no=
start-page=585
end-page=593
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202304
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=IMPACT OF MACULAR INTRARETINAL HEMORRHAGE AND MACULAR HOLE ON THE VISUAL PROGNOSIS OF SUBMACULAR HEMORRHAGE DUE TO RETINAL ARTERIAL MACROANEURYSM RUPTURE
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose: To compare the effects of macular intraretinal hemorrhage (IRH) and macular hole (MH) on best-corrected visual acuity (BCVA) after displacement of submacular hemorrhage (SMH) due to retinal arterial macroaneurysm (RAM) rupture.
Methods: This multicenter retrospective study included 48 eyes with SMH due to RAM rupture. Cases underwent vitrectomy to displace SMH and were followed up for 6 months. We classified cases according to the presence of IRH and MH and compared the postoperative BCVA among the groups.
Results: We classified the eyes into IRH(+)MH(+) group (10 eyes), IRH(+)MH(−) group (23 eyes), and IRH(−)MH(−) group (15 eyes). The postoperative BCVA was significantly worse in the IRH(+)MH(+) and IRH(+)MH(−) groups than in the IRH(−)MH(−) group (0.91 ± 0.41 in logarithm of the minimal angle of resolution units, Snellen equivalent 20/163, 0.87 ± 0.45, 20/148, and 0.18 ± 0.21, 20/30, respectively; P < 0.001). The postoperative central retinal thickness was significantly lower in the IRH(+) group (IRH(+)MH(+) and IRH(+)MH(−) groups combined) than in the IRH(−) group (IRH(−)MH(−) group) (121.4 ± 70.1 µm and 174.3 ± 32.9 µm, respectively, P = 0.008). The postoperative external limiting membrane and ellipsoid zone continuities were significantly discontinuous in the IRH(+) group (P < 0.001, P = 0.001, respectively). The multiple linear regression analysis showed that both IRH(+)MH(+) and IRH(+)MH(−) were associated with the postoperative BCVA (regression coefficient, 0.799 and 0.711, respectively; P < 0.001 for both).
Conclusion: Both IRH and MH were poor prognostic indicators in cases with SMH due to RAM rupture.
en-copyright=
kn-copyright=
en-aut-name=DoiShinichiro
en-aut-sei=Doi
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KimuraShuhei
en-aut-sei=Kimura
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SaitoShoko
en-aut-sei=Saito
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=InoueMakoto
en-aut-sei=Inoue
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=SakuraiToshiya
en-aut-sei=Sakurai
en-aut-mei=Toshiya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KoboriAkira
en-aut-sei=Kobori
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=HisatomiToshio
en-aut-sei=Hisatomi
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=ImaiHisanori
en-aut-sei=Imai
en-aut-mei=Hisanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=KuriyamaShoji
en-aut-sei=Kuriyama
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=TakasuIppei
en-aut-sei=Takasu
en-aut-mei=Ippei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=HosokawaMio Morizane
en-aut-sei=Hosokawa
en-aut-mei=Mio Morizane
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=ShiodeYusuke
en-aut-sei=Shiode
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
en-aut-name=MatobaRyo
en-aut-sei=Matoba
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=
en-aut-name=SuzukiEtsuji
en-aut-sei=Suzuki
en-aut-mei=Etsuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=
en-aut-name=MorizaneYuki
en-aut-sei=Morizane
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=
affil-num=1
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Kyorin Eye Center, Kyorin University School of Medicine
kn-affil=
affil-num=4
en-affil=Kyorin Eye Center, Kyorin University School of Medicine
kn-affil=
affil-num=5
en-affil=Department of Ophthalmology, Tane Memorial Eye Hospital
kn-affil=
affil-num=6
en-affil=Department of Ophthalmology, Fukui Red Cross Hospital
kn-affil=
affil-num=7
en-affil=Department of Ophthalmology, Chikushi Hospital, Fukuoka University
kn-affil=
affil-num=8
en-affil=Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine
kn-affil=
affil-num=9
en-affil=Otowa Eye Center
kn-affil=
affil-num=10
en-affil=Takasu Eye Clinic
kn-affil=
affil-num=11
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=12
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=13
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=14
en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=15
en-affil=Department of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=macular intraretinal hemorrhage
kn-keyword=macular intraretinal hemorrhage
en-keyword=macular hole
kn-keyword=macular hole
en-keyword=submacular hemorrhage
kn-keyword=submacular hemorrhage
en-keyword=retinal arterial macroaneurysm
kn-keyword=retinal arterial macroaneurysm
en-keyword=fluffy sign
kn-keyword=fluffy sign
en-keyword=tissue plasminogen activator
kn-keyword=tissue plasminogen activator
END
start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=1
article-no=
start-page=15449
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220914
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of luseogliflozin and voglibose on high-risk lipid profiles and inflammatory markers in diabetes patients with heart failure
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Sodium-glucose cotransporter 2 inhibitors could reduce cardiovascular events in patients with heart failure irrespective of diabetes status. In this prespecified sub-analysis of randomised-controlled trial, we investigated the efficacy of luseogliflozin (2.5 mg daily), a sodium-glucose cotransporter 2 inhibitor, with that of voglibose (0.6 mg daily), an alpha-glucosidase inhibitor, on high-risk lipid profile and inflammatory markers in patients with type-2 diabetes and heart failure. Among the 157 patients studied, there were no significant differences in the mean malondialdehyde LDL or small-dense LDL cholesterol levels between the luseogliflozin and voglibose groups (percent change: 0.2% vs. - 0.6%, p = 0.93; - 1.7% vs. - 8.6%, p= 0.21) after 12 weeks in comparison to levels at the baseline. No significant difference was observed between the two groups in the adiponectin and high-sensitivity C-reactive protein levels after 12 weeks compared to the baseline levels (percent change, - 1.6% vs. - 4.0% and 22.5% vs. 10.0%; p = 0.52 and p = 0.55, respectively). In conclusion, in patients with type-2 diabetes and heart failure, compared to voglibose, luseogliflozin did not significantly improve the high-risk lipoprotein profile including malondialdehyde LDL and small-dense LDL cholesterol or the levels of inflammatory markers, including adiponectin and high-sensitivity C-reactive protein.
en-copyright=
kn-copyright=
en-aut-name=EjiriKentaro
en-aut-sei=Ejiri
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MiyoshiToru
en-aut-sei=Miyoshi
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KiharaHajime
en-aut-sei=Kihara
en-aut-mei=Hajime
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=HataYoshiki
en-aut-sei=Hata
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NaganoToshihiko
en-aut-sei=Nagano
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=TakaishiAtsushi
en-aut-sei=Takaishi
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=TodaHironobu
en-aut-sei=Toda
en-aut-mei=Hironobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=NambaSeiji
en-aut-sei=Namba
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=NakamuraYoichi
en-aut-sei=Nakamura
en-aut-mei=Yoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=AkagiSatoshi
en-aut-sei=Akagi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=SakuragiSatoru
en-aut-sei=Sakuragi
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=MinagawaTaro
en-aut-sei=Minagawa
en-aut-mei=Taro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
en-aut-name=KawaiYusuke
en-aut-sei=Kawai
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=
en-aut-name=NishiiNobuhiro
en-aut-sei=Nishii
en-aut-mei=Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=
en-aut-name=FukeSoichiro
en-aut-sei=Fuke
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=
en-aut-name=YoshikawaMasaki
en-aut-sei=Yoshikawa
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=
en-aut-name=NakamuraKazufumi
en-aut-sei=Nakamura
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=
en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=
en-aut-name=The MUSCAT-HF Study Investigators
en-aut-sei=The MUSCAT-HF Study Investigators
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=
affil-num=1
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Internal Medicine, Kihara Cardiovascular Clinic
kn-affil=
affil-num=4
en-affil=Department of Cardiology, Minamino Cardiovascular Hospital
kn-affil=
affil-num=5
en-affil=Department of Internal Medicine, Iwasa Hospital
kn-affil=
affil-num=6
en-affil=Department of Cardiology, Mitoyo General Hospital
kn-affil=
affil-num=7
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=8
en-affil=Department of Cardiology, Okayama Rosai Hospital
kn-affil=
affil-num=9
en-affil=Department of Cardiovascular Medicine, Specifed Clinic of Soyokaze Cardiovascular Medicine and Diabetes Care
kn-affil=
affil-num=10
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=11
en-affil=Department of Cardiovascular Medicine, Iwakuni Clinical Center
kn-affil=
affil-num=12
en-affil=Department of Internal Medicine, Minagawa Cardiovascular Clinic
kn-affil=
affil-num=13
en-affil=Department of Cardiovascular Medicine, Okayama City Hospital
kn-affil=
affil-num=14
en-affil=Department of Internal Medicine, Yoshinaga Hospital
kn-affil=
affil-num=15
en-affil=Department of Cardiovascular Medicine, Japanese Red Cross Okayama Hospital
kn-affil=
affil-num=16
en-affil=Department of Cardiology, Fukuyama City Hospital
kn-affil=
affil-num=17
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=18
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=19
en-affil=
kn-affil=
END
start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=1
article-no=
start-page=28
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210113
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effectiveness, safety, and factors associated with the clinical success of endoscopic biliary drainage for patients with hepatocellular carcinoma: a retrospective multicenter study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background
Only a few reports have assessed the effectiveness of endoscopic biliary drainage (EBD) in hepatocellular carcinoma (HCC) patients with obstructive jaundice and liver dysfunction.
Methods
This was a retrospective study based on the clinical databases from the Okayama University Hospital and 10 affiliated hospitals. All patients received EBD for jaundice or liver dysfunction. The indication for EBD was aggravation of jaundice or liver dysfunction with intrahepatic bile duct (IHBD) dilation. The technical and clinical success rate, complications, factors associated with clinical failure, and survival duration were evaluated.
Results
A total of 107 patients were enrolled in this study. Technical success was achieved in 105 of 107 patients (98.1%). Clinical success was achieved in 85 of 105 patients (81%). Complications related to endoscopic retrograde cholangiography (ERC) occurred in 3 (2.8%) patients. Child–Pugh class C (odds ratio 3.90, 95% confidence interval [CI] 1.47–10.4, p = 0.0046) was the only factor associated with clinical failure, irrespective of successful drainage. The median survival duration was significantly longer in patients with clinical success than in those without clinical success (5.0 months vs. 0.93 months; hazard ratio [HR] 3.2, 95% CI 1.87–5.37). HCC Stage I/II/III (HR 0.57, CI 0.34–0.95, p = 0.032), absence of portal thrombosis (HR 0.52, CI 0.32–0.85, p = 0.0099), and clinical success (HR 0.39, CI 0.21–0.70, p = 0.0018) were significant factors associated with a long survival.
Conclusions
EBD for obstructive jaundice and liver dysfunction in patients with HCC can be performed safely with a high technical success rate. Clinical success can improve the survival duration, even in patients expected to have a poor prognosis.
en-copyright=
kn-copyright=
en-aut-name=MatsumiAkihiro
en-aut-sei=Matsumi
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=UekiToru
en-aut-sei=Ueki
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=IshidaEtsuji
en-aut-sei=Ishida
en-aut-mei=Etsuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=TakataniMasahiro
en-aut-sei=Takatani
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=FujiiMasakuni
en-aut-sei=Fujii
en-aut-mei=Masakuni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=WatoMasaki
en-aut-sei=Wato
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=ToyokawaTatsuya
en-aut-sei=Toyokawa
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=HaradaRyo
en-aut-sei=Harada
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=MatsubaraMinoru
en-aut-sei=Matsubara
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=MatsushitaHiroshi
en-aut-sei=Matsushita
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=
affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Internal Medicine, Fukuyama City Hospital
kn-affil=
affil-num=4
en-affil=Department of Gastroenterology, Kurashiki Central Hospital
kn-affil=
affil-num=5
en-affil=Department of Internal Medicine, Japanese Red Cross Society Himeji Hospital
kn-affil=
affil-num=6
en-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital
kn-affil=
affil-num=7
en-affil=Department of Gastroenterology, Kagawa Prefectural Central Hospital
kn-affil=
affil-num=8
en-affil=Department of Gastroenterology, National Hospital Organization Fukuyama Medical Center
kn-affil=
affil-num=9
en-affil=Department of Gastroenterology, Japanese Red Cross Okayama Hospital
kn-affil=
affil-num=10
en-affil=Department of Internal Medicine, Tsuyama Central Hospital
kn-affil=
affil-num=11
en-affil=Department of Internal Medicine, Sumitomo Besshi Hospital
kn-affil=
affil-num=12
en-affil=Department of Gastroenterology, Okayama City Hospital
kn-affil=
affil-num=13
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Endoscopic retrograde cholangiopancreatography
kn-keyword=Endoscopic retrograde cholangiopancreatography
en-keyword=Jaundice
kn-keyword=Jaundice
en-keyword=Hepatocellular carcinoma
kn-keyword=Hepatocellular carcinoma
en-keyword=Liver dysfunction
kn-keyword=Liver dysfunction
END
start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=3
article-no=
start-page=191
end-page=198
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Risk Factors for Chronic Damage Accumulation Across Different Onset Eras in Systemic Lupus Erythematosus: A Cross-sectional Analysis of a Lupus Registry of Nationwide Institutions (LUNA)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity.
en-copyright=
kn-copyright=
en-aut-name=OhashiKeiji
en-aut-sei=Ohashi
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SadaKen-Ei
en-aut-sei=Sada
en-aut-mei=Ken-Ei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=AsanoYosuke
en-aut-sei=Asano
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=HayashiKeigo
en-aut-sei=Hayashi
en-aut-mei=Keigo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YamamuraYuriko
en-aut-sei=Yamamura
en-aut-mei=Yuriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=AsanoSumie Hiramatsu
en-aut-sei=Asano
en-aut-mei=Sumie Hiramatsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MiyawakiYoshia
en-aut-sei=Miyawaki
en-aut-mei=Yoshia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=MorishitaMichiko
en-aut-sei=Morishita
en-aut-mei=Michiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=KatsuyamaEri
en-aut-sei=Katsuyama
en-aut-mei=Eri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=WatanabeHaruki
en-aut-sei=Watanabe
en-aut-mei=Haruki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=TatebeNoriko
en-aut-sei=Tatebe
en-aut-mei=Noriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=NarazakiMariko
en-aut-sei=Narazaki
en-aut-mei=Mariko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
en-aut-name=MatsumotoYoshinori
en-aut-sei=Matsumoto
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=
en-aut-name=Sunahori-WatanabeKatsue
en-aut-sei=Sunahori-Watanabe
en-aut-mei=Katsue
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=
en-aut-name=KawabataTomoko
en-aut-sei=Kawabata
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=
en-aut-name=YajimaNobuyuki
en-aut-sei=Yajima
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=
en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=
affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=4
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=5
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=6
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=7
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=8
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=9
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=10
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=11
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=12
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=13
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=14
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=15
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=16
en-affil=Division of Rheumatology, Department of Medicine, Showa University School of Medicine
kn-affil=
affil-num=17
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=systemic lupus erythematosus
kn-keyword=systemic lupus erythematosus
en-keyword=chronic damage
kn-keyword=chronic damage
en-keyword=glucocorticoids, disease activity
kn-keyword=glucocorticoids, disease activity
en-keyword=disease duration
kn-keyword=disease duration
END
start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200129
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Association between maternal periodontal status and ultrasonographic measurement of fetal growth: A longitudinal study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this prospective cohort study was to investigate the association between intrauterine fetal growth patterns and periodontal status in pregnant women. Fifty-three pregnant women were recruited. Periodontitis was diagnosed based on probing pocket depth and clinical attachment level. Maternal urinary 8-hydroxy-2'-deoxyguanosine levels and body mass index were recorded. Ultrasonographic measurements of the biparietal diameter (BPD), abdominal circumference (AC), and femur length (FL) were recorded, and estimated fetal weight (EFW) was calculated. In addition, approximation spline curves of BPD, AC, FL, and EFW were obtained throughout the gestation period. Recorded delivery outcomes were gestational age (GA), birth weight and length, sex, placental weight, and umbilical cord length. Forty-four participants (34.1 +/- 4.9 years) were analyzed. Mean neonatal birth weight was 2906.0 +/- 544.4g. On multiple regression analysis, birth weight was related with periodontitis (standardized beta=-0.21, P=0.001). For EFW and BPD, the curves of the periodontitis group were located lower than those of the non-periodontitis group, with significant differences after 32 weeks and 20 weeks of GA, respectively. In conclusion, periodontal treatment before conception may be recommended and a good periodontal condition in the early stage of pregnancy at the latest is desirable for infant growth.
en-copyright=
kn-copyright=
en-aut-name=Taniguchi-TabataAyano
en-aut-sei=Taniguchi-Tabata
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=TakeuchiNoriko
en-aut-sei=Takeuchi
en-aut-mei=Noriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=UchidaYoko
en-aut-sei=Uchida
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=EkuniDaisuke
en-aut-sei=Ekuni
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=MoritaManabu
en-aut-sei=Morita
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=Department of Preventive Dentistry, Okayama University Hospital
kn-affil=
affil-num=2
en-affil=Department of Preventive Dentistry, Okayama University Hospital
kn-affil=
affil-num=3
en-affil=Department of Preventive Dentistry, Okayama University Hospital
kn-affil=
affil-num=4
en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=5
en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Periodontitis
kn-keyword=Periodontitis
en-keyword=Risk factors
kn-keyword=Risk factors
END
start-ver=1.4
cd-journal=joma
no-vol=49
cd-vols=
no-issue=5
article-no=
start-page=478
end-page=483
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190621
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Arousal from Tonic Immobility by Vibration Stimulus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Tonic immobility (TI) is an effective anti-predator strategy. However, long immobility status on the ground increases the risk of being eaten by predators, and thus insects must rouse themselves when appropriate stimulation is provided. Here, the strength of vibration causing arousal from the state of TI was examined in strains artificially selected for longer duration of TI (L-strains: long sleeper) in a beetle. We provided different strengths of vibration stimuli to the long sleepers in Tribolium castaneum. Although immobilized beetles were never awakened by the stimuli from 0.01 to 0.12 mm in amplitude, almost of the beetles were aroused from immobilized status by the stimulus at 0.21 mm. There was a difference in sensitivity of individuals when the stimuli of 0.14 mm and 0.18 mm were provided. F2 individuals were also bred by crossing experiments of the strains selected for shorter and longer duration of TI. The arousal sensitivity to vibration was well separated in the F2 individuals. A positive relationship was observed between the duration of TI and the vibration amplitude, suggesting that immobilized beetles are difficult to arouse from a deep sleep, while light sleepers are easily aroused by even small vibrations. The results indicate a genetic basis for sensitivity to arousal from TI.
en-copyright=
kn-copyright=
en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KitayamaRyota
en-aut-sei=Kitayama
en-aut-mei=Ryota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=OtsukiKeiichi
en-aut-sei=Otsuki
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=JiYuhao
en-aut-sei=Ji
en-aut-mei=Yuhao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=FujisawaRyusuke
en-aut-sei=Fujisawa
en-aut-mei=Ryusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=NagayaNaohisa
en-aut-sei=Nagaya
en-aut-mei=Naohisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
affil-num=1
en-affil=Department of Evolutionary Ecology, Graduate School of Environmental and Life ScienceOkayama University
kn-affil=
affil-num=2
en-affil=Department of Evolutionary Ecology, Graduate School of Environmental and Life ScienceOkayama University
kn-affil=
affil-num=3
en-affil=Department of Evolutionary Ecology, Graduate School of Environmental and Life ScienceOkayama University
kn-affil=
affil-num=4
en-affil=Faculty of Computer Science and Engineering Kyoto Sangyo University
kn-affil=
affil-num=5
en-affil=Department of Evolutionary Ecology, Graduate School of Environmental and Life ScienceOkayama University
kn-affil=
affil-num=6
en-affil=School of Computer Science and Systems EngineeringKyushu Institute of Technology
kn-affil=
affil-num=7
en-affil=Faculty of Computer Science and Engineering Kyoto Sangyo University
kn-affil=
en-keyword=Beetle
kn-keyword=Beetle
en-keyword=Crossing experiment
kn-keyword=Crossing experiment
en-keyword=Death feigning
kn-keyword=Death feigning
en-keyword=Selection experiment
kn-keyword=Selection experiment
en-keyword=Thanatosis
kn-keyword=Thanatosis
en-keyword=Tribolium
kn-keyword=Tribolium
END
start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=9
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20131212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of repeated Waon therapy on exercise tolerance and pulmonary function in patients with chronic obstructive pulmonary disease: a pilot controlled clinical trial
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose: Controlled clinical trials evaluating the efficacy of repeated Waon therapy for patients with chronic obstructive pulmonary disease (COPD) have yet to be conducted. The purpose of the present study was to evaluate whether repeated Waon therapy exhibits an adjuvant effect on conventional therapy for COPD patients.
Patients and methods: This prospective trial comprised 20 consecutive COPD patients who satisfied the criteria of the Global initiative for chronic Obstructive Lung Disease (GOLD) guidelines, stages 1–4. They were assigned to either a Waon or control group. The patients in the Waon group received both repeated Waon therapy and conventional therapy, including medications, such as long-acting inhaled β2 agonists, long-acting anticholinergics and xanthine derivatives, and pulmonary rehabilitation. The Waon therapy consisted of sitting in a 60°C sauna room for 15 minutes, followed by 30 minutes of being warmed with blankets once a day, 5 days a week, for a total of 20 times. The patients in the control group received only conventional therapy. Pulmonary function and the 6-minute walk test were assessed before and at 4 weeks after the program.
Results: The change in vital capacity (0.30 ± 0.4 L) and in peak expiratory flow (0.48 ± 0.79 L/s) in the Waon group was larger than the change in the vital capacity (0.02 ± 0.21 L) (P=0.077) and peak expiratory flow (−0.11 ± 0.72 L/s) (P=0.095) in the control group. The change in forced expiratory flow after 50% of expired forced vital capacity in the Waon group, 0.08 (0.01–0.212 L/s), was larger than that in the control group, −0.01 (−0.075–0.04 L/s) (P=0.019). Significant differences were not observed in the change in any parameters in the 6-minute walk test. Data are presented as means ± standard deviation or median (25th–75th percentile).
Conclusion: The addition of repeated Waon therapy to conventional therapy for COPD patients can possibly improve airway obstruction.
en-copyright=
kn-copyright=
en-aut-name=KikuchiHiroshi
en-aut-sei=Kikuchi
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=ShiozawaNobuyoshi
en-aut-sei=Shiozawa
en-aut-mei=Nobuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Okayama Univ Hosp, Misasa Med Ctr, Div Med
affil-num=2
en-affil=
kn-affil=Okayama Univ Hosp, Misasa Med Ctr, Div Med
affil-num=3
en-affil=
kn-affil=Okayama Univ Hosp, Misasa Med Ctr, Div Med
affil-num=4
en-affil=
kn-affil=Okayama Univ Hosp, Misasa Med Ctr, Div Med
affil-num=5
en-affil=
kn-affil=Okayama Univ Hosp, Misasa Med Ctr, Div Med
en-keyword=modified Borg scale
kn-keyword=modified Borg scale
en-keyword=airway obstruction
kn-keyword=airway obstruction
en-keyword=6-minute walk test
kn-keyword=6-minute walk test
en-keyword=quality of life
kn-keyword=quality of life
END
start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=6
article-no=
start-page=1205
end-page=1219
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1929
dt-pub=19290630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Über die Veränderungen des Blutzuckers und des Zuckers im Harn bei mit verschiedenem Fett und Lipoiden gefütterten Kaninchen (I. Bei mit Lanolin gefütterten Kaninchen)
kn-title=種々ノ脂肪質及ビ類脂肪質飼食ニ因スル家兎血糖ノ變化竝ニ糖尿ニ就テ（第1「ラノリン」飼養家兎ニ就テ）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1) Die lange andauernde Fütterung von Kaninchen mit Lanolin hat eine ziemlich beträchtliche Steigerung des Blutzuckers zur Folge. 2) Die Lanolinmenge, welche diese Hyperglykämie verursachen kann, beläuft sich auf ca. 100g. 3) Der Zuckergehalt zu nüchterner Zeit beträgt 0.14-0.16, nach Speiseaufnahme 0.17-0.21. 4) Die Hyperglykämie bei diesem Experiment ist von ziemlicher Dauer, nicht nur vorübergehend wie in dem Falle von Sakurai. Betreffs der Ursache ist aus dem oben angegebenen Grunde nicht an eine vorübergehende Verschiebung des Leberglykogens zu denken, in Analogie mit Sakurai's Erklärung. 5) Die Intensität sowie die Zeitdauer der Entstehung dieser Hyperglykämie sind gänzlich individuell verschieden. 6) Bei verhältnismässig stärkerer Hyperglykämie ist bereits nach einer Stunde seit der Nahrungsaufnahme Glykosurie nachweisbar. Jedoch ist die Intensität der Zuckerreaktion in der Regel eine schwache und tatsächlich nur spurweise erkennbar, selten einigermassen in die Augen fallend. 7) Falls die Lanolinverfütterung weiterhin längere Zeit hindurch ausgeführt wird, und die verschiedenen Veränderungen wie Abmagerung in die Erscheinung treten, nimmt der Blutzuckergehalt wieber ab und scheint sich dem Normalen zu nähern. Besonders bei Anwesenheit eines Eiterungsherdes ist die Abnahme des Blutzuckergehaltes deutlich. 8) Am Pankreas, insbesondere an den Langerhans'schen Inseln, bei solchen Kaninchen, an welchen Hyperglykämie und insbesondere Glykosurie in die Erscheinung traten, sind keine besonderen pathologisch-histologischen Veränderungen wahrnehmbar.
en-copyright=
kn-copyright=
en-aut-name=KohashiMasaka
en-aut-sei=Kohashi
en-aut-mei=Masaka
kn-aut-name=小橋政香
kn-aut-sei=小橋
kn-aut-mei=政香
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=兵庫縣立神戸病院病理科研究室
END
start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=11
article-no=
start-page=2672
end-page=2703
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1940
dt-pub=19401130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Klinische Untersuchungen über Resorption und Ausscheidung I von Wismutpräparaten. (I. Teil) Untersuchung über Resorption und Ausscheidung von Milaneuen, Thiobis und Perbismol.
kn-title=蒼鉛劑ノ吸收竝ニ排泄ニ關スル臨牀的研究（第1編）Milaneuen, Thiobis及ビPerbismolノ吸收竝ニ排泄ニ關スル研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I) Der Verfasser ist bei der Gesundheitsprufüngsstelle der staatlichen Volksversicherung Tamasima, Okayama-ken, angestellt. Seine Untersuchungen betreffen Syphiliskranke: Die Kranken erhielten von ihm Milaneuen-, Perbismol-und Thiobis-Injektionen. 1. Nach den einzelnen, verschiedenen Injektionen wurdan die Bi-Ausscheidungsprodukte des Harns untersucht. 2. Bei den Milaneuen-Injektionen wurden die Bi-Ausscheidungen sowohl des Harnsvom Tage als auch von der Nacht untersucht. 3. 141 Tage hindürch wurden diese Untersuchungen bei Milaneuen jede Stunde durchgefuhrt. II) Die stündlich untersuchten Bi-Ausscheidungen nach Injektion von Milaneuen (2.0cc=96.4mg Bi) und Perbismol (20cc=45.8mg) ergaben eine ungleiche Menge, aber nahezu das gleiche Ausscheidungsbild. Nach den Thiobis-Injektionen (1.4cc=52.22mg) waren die Ausscheidungen des Bi znerst sehr hoch, um dann plötzlich stark zu fallen, so dass die Ausscheidungsmenge sich nunmehr ungefähr in der Höhe der Ausscheidungsmenge nach Injektionen von Milaneuen und Perbismol hielt. 1. D.h. bei Milaneuen, Perbismol, Thiobis ist die Ausscheidungsmenge innerhalb der ersten Stunde jeweils 0.0032mg, O.0110mg und 3.1325mg. Vergleicht man die In- jektionsmenge mit der Ausscheidungsmenge, so ergibt sich für Milaneuen, Perbismol, Thiobis jeweils ein Prozentsatz von 0.003%, 0.024%, 5.99%. D.h. die Ausscheidungsmenge ist bei Perbismol das 8-fache derjenigen von Milaneuen. Der Prozentsatz bei Thiobis ist sehr hoch, nämlich das 250-fache der Ausscheidungsmenge bei Perbismol, und das 2000-fache der Ausscheidungsmenge bei Milaneuen-Injektionen. 2. Damit verglichen waren die Ausscheidungsprodukte nach der zweiten Stunde das 4-fache bei Milaneuen, das 3-fache bei Perbismol, dagegen nur 1/3 bei Thiobis. Darauf verlief der Ausscheidungsprozess folgendermassen: a) Bei Milaneuen sehr langsam zunehmend: nach der 7 Stunde beträgt die Ausscheidungsmenge 0.025%, die sich nach der 11. Stunde noch nicht geandert hat. b) Bei Perbismol ist der Aussche dungsprozess, verglichen mit dem beim Milaneuen, nach der 6. St. das 5-6-fache; von der 7.-9. St. das 2.7-3.8-fache; in der 10. und 11. St. wieder zunehmend das 5-6-fache. c) Thiobis dagegen zeigt lediglich stundlich eine treppenartige Abnahme, so dass. schliesslich seine Ausscheidungsmenge sich der von Milaneuen und Perbismol sehr stark nähert. So ist nach der 11. St. der Prozentsatz bei Thiobis derselbe wie der von Perbismo1 (1.03%). III) Die Untersuchung der Bi-Ausscheidungsprodukte im Harn bis zur elften St ergab bei Perbismol ungefähr das 5-fache ale bei Milaneuen. Thiobis ergab den höchsten Prozentsatz, nämlich 12.07%, d.h. das 12-fache des Prozentsatzes bei Perbismol (1.03%) und das 60-fache des Prozentsatzes bei Milaneuen (0.21%).
1. Nach der In jektion von Milaneuen war die stündliche Ausscheidungsmenge von der 25. St. bis zur 1. St. am 6. Tage fast gleich; sie betrug das 6-10-fache des in der 10. und 11. St. ausgeschiedenen Bi. In der 1. St. des 13. Tages zeigte sich eine Abnahme. Bei Perbismol war die Ausscheidungsmenge in der Zeit von der 25. St. bis zur 1. St. des 8. Tages nach der Injektion ungefähr gleich oder etwas weniger als in der 10. und 11. St. nach der gleichen Injektion. Bei Thiobis war die Bi-Ausscheidungsmenge der 25. St. ungefähr der der 11. St. gleich. Danach zeigt sich eine plötzlich Abnahme. Die vom 6. bis zum 9. Tage stündlich ausgeschiedene Menge, verglichen mit der von der 11. St., beträgt nur noch 1/2-1/3, am 14. und 15. Tage nur noch 1/5-1/10; am 20. Tage nach der 1. St. ist Bi kaum nachweisbar. Bei fräheren Untersuchungen wurde jeweils nur 1.0cc der Harnmenge auf das ausgeschiedene Bi hin untersucht und zur Darstellung gebracht. Nahrungsaufnahme und Blutdruck haben auf die Bi-Ausscheidungen keinen Einfluss. Milaneuen und Perbismol zeigen nach der Injektion keine diuretischen Wirkungen, wohl dagegen in hohem Grade Thiobis und zwar in der 1.-3. Stunde nach der Injektion. Diese diuretische Wirkung, d.h. eine starke Harnaussckeidung, tritt nach der Thiobis-Injektion entweder gleichzeitig mit oder unmilttelbar nach der höchsten Bi-Ausscheidung ein. Die Ursache dafür dürfte in der beträchtlichen Zahl der Bi-Ionen, die der Körper resorbiert, zu suchen sein. IV) Die Wirkung der gleichen Injektionsmenge desselben Bi-Praparates ist bei den einzelnen Kranken, was die Menge der Bi-Ausscheidung angeht, individuell verschieden, zeigt aber immer das nahezu gleiche Ausscheidungsbild. Gibt man zu verschiedenen Zeiten demselben Kranken die gleiche Injektionsmenge des gleichen Bi-Präparates, so ist die Bi-Auescheidungsmenge nach der 1. Injektion grösser als die nach der 2. Injektion, aber das Kurvenbild bleibt wiederum nachezu das gleiche. Die Injizierungend er verschiedenen Bi-Präparate am selben Kranken ergeben jeweils ein ganz verschiedenes Ausscheidungsbild. V) Bei Milaneuen ist die durchschnittliche sündliche Bi-Ausscheidungsmenge in der Wachzeit grösser als in der Schlafzeit, wenn der Schlaf normal war. War dagegen der Schlaf gestört, so war die Bi-Ausscheidungsmenge grösser als in der Wachzeit. In der Wachzeit war die stündlich ausgeschiedene Harnmenge im allgemeinen vormittags grösser als nachmittags. Doch ist natürlich der Einfluss der Nahrungs- und Flüssigkeitsaufnahme zu berücksichtigen. VI) Bei Milaneuen verläuft der Ausscheidungsprozess von Bi sehr träge ; es handelt sich um die sogenannte lineare Ausscheidung. Doch istd ie durcitschnittliche stündliche Bi-Ausscheidungsmenge in der Wachzeit stets grösser-bisweilen beträchtlich grösser - als
in der Schlafzeit. Bei gestörtem Schlaf war die durchschnittliche stündliche Bi-Ausscheidungsmenge
die gleiche oder etwas grösser als in der Wachzeit. Im grossen und ganzen genommen ist die stündliche Bi-Ausscheidungsmenge in der Wachzeit für die Nachbarzeiten nachezu gleich (lineare Ausscheidung); doch ist, genauer gesprochen, die stündliche Bi-Ausscheidungsmenge am Vormittag im allgemeinen grösser als am Nachmittag. Die Nahrungsaufnahme übt auf die Bi-Ausscheidungsmenge der Wachzeit keinen besonderen Einfluss aus. Ferner, wenn die Harnmenge zunimmt, nimmt auch die Bi-Ausscheidungsmenge zu. Wenn dagegen die Harnmenge abnimmt, vermindert sich die Bi-Ausscheidungsmenge nicht dementsprechend ; sie sinkt vielmehr nie unter eine bestimmte
Menge. VII) Die Untersuchung der Bi-Ausscheidungsmenge, die nach 15 Injektionen zur
gleichen, festgesetzten Stunde in gewissen Zeitabschnitten einmal, und zwar lange Zeit hindurch, stattfand, hatte folgende Ergebnisse : a) Zur Zeit der grössten Bi-Ausscheidung findet im allgemeinen auch die Diurese statt. b) Bei jeder stündlichen Untersuchung zeigte die ausgeschiedene Bi-Menge in der Harnmenge einer Stunde eine fortlaufende allmähliche Verminderung. Starke Bi-Ausscheidungen entspricht eine schnelle Ausscheidungssenkung. Schwachen Bi-Ausscheidungen entspricht eine sehr träge Abnahme ; jedoch war nach vier Monaten eine weitere Bi-Abnahme kaum mehr bemerkbar. In der letzten Untersuchung am 141. Tage wurde in der Harnmenge einer Stunde eine Bi-Menge von 0.02494mg festgestellt.
en-copyright=
kn-copyright=
en-aut-name=SekiTensisu
en-aut-sei=Seki
en-aut-mei=Tensisu
kn-aut-name=石天之樞
kn-aut-sei=石
kn-aut-mei=天之樞
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山醫科大學皮膚科泌尿器科教室
END
start-ver=1.4
cd-journal=joma
no-vol=69
cd-vols=
no-issue=3
article-no=
start-page=727
end-page=729
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1957
dt-pub=19570331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=EXPERIMENTAL STUDY ON PREVENTION AGAINST EXPLOSION OF ANESTHETIC GAS (ETHER AND CYCLOPROPANE) PART IV. ON THE CONCENTRATION OF ETHER GAS AND CYCLOPROPANE IN THE AIR BY EXPIRATION
kn-title=麻酔用ガス（ether及びcyclopropane）の爆発防止に関する基礎的研究 第4篇 呼気排泄による空気中のetherガス並びにcyclopropane濃度に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Guinea pigs anesthesized with ether or cyclopropane were confined in a closed box and the concentration of anesthetic gas in the box was measured by interferometer with the lapse of time. 1) The gases in the closed box showed the highest concentration from 40 to 60 minutes later and the maximum concentration was about 0.16% in case of ether gas, but in case of cyclopropane the former was after 40 minutes and the latter was 0.21%. These concentrations were about one-twelfth of the lower explosive limits. 2) This condition corresponded to the case, that a human adult was confined in a room with a size of 7m3. Therefore, it is concluded that, the only anesthetic gases from expiration of patients cannot reach an inflammable concentration.
en-copyright=
kn-copyright=
en-aut-name=SakashitaNoboru
en-aut-sei=Sakashita
en-aut-mei=Noboru
kn-aut-name=坂下昇
kn-aut-sei=坂下
kn-aut-mei=昇
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
END
start-ver=1.4
cd-journal=joma
no-vol=63
cd-vols=
no-issue=6
article-no=
start-page=325
end-page=330
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inverse Correlation between Adiponectin and the Risk of Metabolic Syndrome in Middle-aged Japanese Male Workers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Despite a close association between adiponectin and both hypertension and type 2 diabetes, the relationship between adiponectin and metabolic syndrome has not yet been well-investigated. To examine and evaluate the association between serum adiponectin levels and metabolic syndrome based on Japanese diagnostic criteria, we analyzed adiponectin and anthropometric parameters in 869 male employees aged 40-59 who belonged to a health insurance society in Fukuoka Prefecture and who underwent annual health check-ups from August 2006 to July 2007. Two hundred and thirty-two of the 869 subjects (26.7%) were diagnosed with metabolic syndrome. The serum adiponectin levels were significantly higher in the non-metabolic syndrome group. In a multiple logistic regression analysis, the subjects in the top quartile of serum adiponectin (adjusted odds ratio:0.36;95% confidence interval:0.21-0.63) and the second (adjusted odds ratio:0.51;95% confidence interval:0.31-0.84) quartile had a significantly decreased risk for metabolic syndrome in comparison to the bottom quartile. The dose-response relationship between serum adiponectin levels and metabolic syndrome was significant (p for trend 0.0001) after adjusting for age, body mass index, smoking status, and drinking status. The current findings suggest that hypoadiponectinemia is inversely correlated with the risk of metabolic syndrome in middle-aged Japanese male workers.
en-copyright=
kn-copyright=
en-aut-name=TaniharaShinichi
en-aut-sei=Tanihara
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=ImatohTakuya
en-aut-sei=Imatoh
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MomoseYoshito
en-aut-sei=Momose
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MiyazakiMotonobu
en-aut-sei=Miyazaki
en-aut-mei=Motonobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=UneHiroshi
en-aut-sei=Une
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University
affil-num=2
en-affil=
kn-affil=Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University
affil-num=3
en-affil=
kn-affil=Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University
affil-num=4
en-affil=
kn-affil=Department of Health and Welfare, Saitama City Government
affil-num=5
en-affil=
kn-affil=Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University
en-keyword=metabolic syndrome
kn-keyword=metabolic syndrome
en-keyword=epidemiology
kn-keyword=epidemiology
en-keyword=adiponectin
kn-keyword=adiponectin
en-keyword=body mass index
kn-keyword=body mass index
en-keyword=waist circumference
kn-keyword=waist circumference
END
start-ver=1.4
cd-journal=joma
no-vol=51
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=11
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=199702
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Measurements of axial length and radius of corneal curvature in the rabbit eye
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The axial length of the eye, the radius of the anterior corneal surface, and the diameter of the cornea were measured on 40 eyes of 20 New Zealand White rabbits. The ultrasonographic measurements of the axial length of the eye showed a mean value of 15.12 ± 0.51mm (15.33 ± 0.50mm in males, 14.96 ± 0.46mm in females). The mean corneal radius was 7.26 ± 0.26mm (7.18 ± 0.9mm in males, 7.32 ± 0.33 mm in females); the mean value of the difference in corneal curvature between two principle meridians was 0.21 ± 0.12mm; and the mean horizontal and vertical diameters of the cornea were 13.41 ± 0.34mm and 13.02 ± 0.30mm, respectively. Although the diameter of the cornea of rabbits was bigger than that of humans (average, horizontal 11.75mm, vertical 10.55mm), the axial length of the eye was 0.7 times that of humans (23-24mm), and the radius of corneal curvature was relatively smaller than that in humans (7.7-7.8mm).
en-copyright=
kn-copyright=
en-aut-name=BozkirGulhal
en-aut-sei=Bozkir
en-aut-mei=Gulhal
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=BozkirMurat
en-aut-sei=Bozkir
en-aut-mei=Murat
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=DoganHakki
en-aut-sei=Dogan
en-aut-mei=Hakki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=AycanKenan
en-aut-sei=Aycan
en-aut-mei=Kenan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=GulerBaki
en-aut-sei=Guler
en-aut-mei=Baki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=The Çukurova University
affil-num=2
en-affil=
kn-affil=The Erciyes University
affil-num=3
en-affil=
kn-affil=The Erciyes University
affil-num=4
en-affil=
kn-affil=The Erciyes University
affil-num=5
en-affil=
kn-affil=The Erciyes University
en-keyword=rabbit eye
kn-keyword=rabbit eye
en-keyword=bulbus oculi
kn-keyword=bulbus oculi
en-keyword=radius of cornea
kn-keyword=radius of cornea
en-keyword=axial length
kn-keyword=axial length
END
start-ver=1.4
cd-journal=joma
no-vol=56
cd-vols=
no-issue=
article-no=
start-page=1
end-page=4
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19850330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Radioactivity and chromosome aberrations of residents of Misasa Spa
kn-title=三朝温泉地の自然放射能と住民の末梢血染色体異常について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Misasa Spa is one of the most highly radioactive hot springs in Japan, the waters of which contain mainly (222)Rn (437±132 Bq/liter). Radon contents of indoor air of private houses and health resort hotels (built of wood) at Misasa Spa range from 18.5 to 55.5 mBq/liter and 22.2 to
129.5 mBq/liter, respectively. Radon contents in the air of facilities using spring waters at Misasa Branch Hospital of Okayama University were measured to be ; bathroom 807±78 mBq/liter; Hubbardtank bathroom 5306±2568 mBq/liter ; the drinking hall 1491±178 mBq/liter. The environmental and dose rate inside private houses has been measured to be 14.0±1.8 μR/h. Chromosome aberrations (dicentrics) in the peripheral blood lymphocytes of residents of Misasa Spa were investigated in 14 persons; the mean value of aberration frequencies were 0.21%.
en-copyright=
kn-copyright=
en-aut-name=MorinagaHiroshi
en-aut-sei=Morinaga
en-aut-mei=Hiroshi
kn-aut-name=森永寛
kn-aut-sei=森永
kn-aut-mei=寛
aut-affil-num=1
ORCID=
en-aut-name=MifuneMasaaki
en-aut-sei=Mifune
en-aut-mei=Masaaki
kn-aut-name=御船政明
kn-aut-sei=御船
kn-aut-mei=政明
aut-affil-num=2
ORCID=
en-aut-name=FurunoKatsuaki
en-aut-sei=Furuno
en-aut-mei=Katsuaki
kn-aut-name=古野勝志
kn-aut-sei=古野
kn-aut-mei=勝志
aut-affil-num=3
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院
affil-num=2
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院
affil-num=3
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院
END
start-ver=1.4
cd-journal=joma
no-vol=99
cd-vols=
no-issue=9-10
article-no=
start-page=1205
end-page=1221
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1987
dt-pub=19871031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on respiratory diseases by bronchoalveolar lavage fluid Part 1. Estimation of immunoglobulins and histamine in bronchoalveolar lavage fluid
kn-title=気道液性成分からみた呼吸器疾患の研究 第1編 気管支肺胞洗浄液における免液グロブリン及びヒスタミン
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Immunoglobulins and histamine were estimated in bronchoalveolar lavage fluid (BALF) of 25 patients with bronchial asthma, 7 patients with hypersensitivity pneumonitis, 8 patients with sarcoidosis and 3 patients with bronchiolitis. In 8 healthy subjects, relation levels of immunoglobulins and histamine in BALF were: IgG/alb ratio, 0.28±0.17 (mg/mg); IgA/alb ratio, 0.19±0.15; IgM/alb ratio, 0.01±0.01; IgE/alb ratio, 0.36±0.29×10(2)(IU/mg), and His/alb ratio, 0.67±0.29 (ng/mg). In asthmatic patients, the relation levels of immunoglobulins and histamine in BALF were: IgG/alb ratio, 0.26±0.21; IgA/alb ratio, 0.11±0.06; IgM/alb ratio, 0.01±0.01; IgE/alb ratio, 0.89±0.99×10(2), and His/alb ratio, 1.38±0.84. These patients showed a moderately higher His/alb ratio than healthy subjects. The increased His/alb ratio was closely related to immediate skin tests and serum IgE levels, especially in atopic patients. An inverse relationship was noted between an elevated IgE/alb ratio and/or His/alb ratio and the degree of peripheral airway obstruction. There was a relationship between an elevated IgG/alb ratio and peripheral airway obstruction, although there was no significant relationship between immunoglobulins/alb and/or His/alb ratios and the results of pulmonary function tests. Somewhat higher IgG/ alb and IgM/alb ratios were found in the patients with hypersensitivity pneumonitis than in the healthy subjects, although significantly higher ratios were not observed in patients with sarcoidosis or bronchiolitis. In conclusion, the estimation of immunoglobulins and histamine in BALF is considered to be useful for the explication of the pathogenic mechanism of bronchial asthma.
en-copyright=
kn-copyright=
en-aut-name=SudoMichiyasu
en-aut-sei=Sudo
en-aut-mei=Michiyasu
kn-aut-name=周藤眞康
kn-aut-sei=周藤
kn-aut-mei=眞康
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科学教室
en-keyword=気管支肺胞洗浄
kn-keyword=気管支肺胞洗浄
en-keyword=気管支喘息
kn-keyword=気管支喘息
en-keyword=免疫グロブリン
kn-keyword=免疫グロブリン
en-keyword=ヒスタミン
kn-keyword=ヒスタミン
END
start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=2
article-no=
start-page=145
end-page=152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Abnormal polyunsaturated fatty acid pattern in plasma physholipiods and its clinical significance in patients with hepatocellular carcinoma snd live cirrhosis
kn-title=肝細胞癌症例および非坦癌肝硬変症例にみられる血漿リン脂質多価不飽和脂肪酸形成の異常と臨床の意義
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of present syudy is to analyze fatty acid composition in plasma phospolipids in patients with hepatocellular carcinoma (HCC) and live cirrhosis (LC) and to elucidate the significance of polunsaturated fatty acid on hepatocarcinogenesis. Arachidonic acid/Linoleic acid (AA/LA) molar ratios in plasma phosphatidylinositol in LC (1.42±0.29,p<0.01) and in HCC (1.24±0.12,p<0.001) were significantly lower than that in control subjects (2.78±0.16). The AA/LA molar ratio in plasma phoshatidylethanolamine in HCC(1.07±0.13) was significantly lower than that in control subjecls (1.94±0.21,p<0.01). The plasma lysophospatidyclholine (LysoPC) concentration in HCC (71.6±8.4nmol/ml, p<0.001) and in LC(80.9±12.0 nmol/ml, p<0.001) were siginificantly lower than that in control subjects (146.7±5.7nmol/ml). Plasma arachidonoy-LysoPC was siginificantly in HCC(3.2±0.5mol%) compared with that in LC (1.5±0.3mol%,p<0.01) and in control subjecys (1.9±0.1mol%,p<0.01). Plasma arachidonoy-LysoPC may play an importhant role in the pathophysiology of HCC patients.
en-copyright=
kn-copyright=
en-aut-name=YokoyamaJunko
en-aut-sei=Yokoyama
en-aut-mei=Junko
kn-aut-name=横山純子
kn-aut-sei=横山
kn-aut-mei=純子
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry
en-keyword=plasma phospholipids
kn-keyword=plasma phospholipids
en-keyword=arachidonic acird
kn-keyword=arachidonic acird
en-keyword=lysophosphatidylcholine
kn-keyword=lysophosphatidylcholine
en-keyword=hepatocellular carcinoma
kn-keyword=hepatocellular carcinoma
en-keyword=liver chrrhosis
kn-keyword=liver chrrhosis
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=近視学童における部分的干渉測定法を用いた眼軸長測定について：測定のリピータビリティと屈折要素との比較
kn-title=Axial Length Measurement Using Partial Coherence Interferometry in Myopic Children: Repeatability of the Measurement and Comparison with Refractive Components
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=PURPOSE: To evaluate the test-retest repeatability of axial length (AL) measurements made with the IOLMaster in children with a wide range of myopic refractive errors, and to clarify the relationship between the AL and other refractive components. METHODS: The subjects were 95 children (mean age +/- SD, 10.8 +/- 1.3 years; range, 7-13 years; mean refractive error; -4.37 +/- 1.43 D; range, -1.50 to -8.19 D) who participated in a myopia-control trial. The AL of the right eye was measured three times using an IOLMaster, and the mean value was regarded as the representative measurement. After 5 min, the measurement was performed again, and the repeatability was evaluated by analyzing the distribution of differences between the two measurements. The relationships between the AL and age, cycloplegic autorefraction (RE), and corneal radius of curvature (CR) were also examined. RESULTS: The repeatability of the IOLMaster measurements was +/-0.05 mm (corresponding to a refractive error of +/-0.12 D) and was not affected by age or RE. AL was negatively correlated with RE (RE = -0.68 x AL + 12.74, r = -0.37) and positively correlated with CR (CR = 0.21 x AL + 2.53, r = 0.69). The highest correlation was found between the ratio of AL to CR and RE (AL/CR = -0.04 x RE + 3.08, r = -0.76). No association was observed between age and AL, nor between CR and RE. CONCLUSIONS: The IOLMaster provides high repeatability in AL measurement in myopic children. The associations between AL and each refractive component found in this study were consistent with those in previous studies that used the ultrasound A-mode method, except for slightly higher AL/CR ratios in our study.
en-copyright=
kn-copyright=
en-aut-name=KimuraShuhei
en-aut-sei=Kimura
en-aut-mei=Shuhei
kn-aut-name=木村修平
kn-aut-sei=木村
kn-aut-mei=修平
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学
en-keyword=axial length
kn-keyword=axial length
en-keyword=myopic children
kn-keyword=myopic children
en-keyword=partial coherence interferometry
kn-keyword=partial coherence interferometry
en-keyword=refractive components
kn-keyword=refractive components
en-keyword=repeatability
kn-keyword=repeatability
END
start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=1
article-no=
start-page=59
end-page=65
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=1996
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Population Increases of the Green Peach Aphid, Myzus persicae (Sulzer) and Cotton Aphid, Aphis gossypii Glover
kn-title=モモアカアブラムシとワタアブラムシの個体群増殖
en-subtitle=
kn-subtitle=
en-abstract=モモアカアブラムシとワタアブラムシについて、それぞれダイコンとキュウリを餌植物として、一連の温度条件での個体群増殖のパラメータを求めた。産子数はアカアブラムシの方が多かった。しかし、生存期間はワタアブラムシの方が長かった。羽化後の日別産子数と日別生存率から求めた純繁殖率と内的自然増加率は、モモアカアブラムシでは、15℃で、61.50と0.21、20℃で60.60と0.33であった。ワタアブラムシでは、15℃で37.90と0.22、20℃で45.70と0.32、25℃で40.60と0.42であった。
kn-abstract=The reproduction of Myzus persicae (Sulz.) on raddish and Aphis gossypii Glover on cucumber was studied at different temperatures. The parameters of population growth in these aphids were calculated by the age-specific fecundities (mx) and survival rate (lx). The net reproductive rate (R0) and intrinsic rate of natural increase (r) of M. persicae were 61.50 and 0.21 at 15℃, and 60.60 and 0.33 at 20℃, respectively. The net reproductive rate (R0) and intrinsic rate of natural increase (r) of A. gossypii were 37.90 and 0.22 at 15℃, 45.70 and 0.32 at 20℃, and 40.60 and 0.42 at 25℃, respectively.
en-copyright=
kn-copyright=
en-aut-name=MuraiTamotsu
en-aut-sei=Murai
en-aut-mei=Tamotsu
kn-aut-name=村井保
kn-aut-sei=村井
kn-aut-mei=保
aut-affil-num=1
ORCID=
en-aut-name=TsumukiHisaaki
en-aut-sei=Tsumuki
en-aut-mei=Hisaaki
kn-aut-name=積木久明
kn-aut-sei=積木
kn-aut-mei=久明
aut-affil-num=2
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学
affil-num=2
en-affil=
kn-affil=岡山大学
en-keyword=Population growth
kn-keyword=Population growth
en-keyword=Net reproductive rate
kn-keyword=Net reproductive rate
en-keyword=Intrinsic rate
kn-keyword=Intrinsic rate
en-keyword=Myzus persicae
kn-keyword=Myzus persicae
en-keyword=Aphis gossypii
kn-keyword=Aphis gossypii
END