start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=インプラント周囲炎患者の患部歯槽骨密度を定量測定する新規評価法の信頼性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SHIMOMURAYuji en-aut-sei=SHIMOMURA en-aut-mei=Yuji kn-aut-name=下村侑司 kn-aut-sei=下村 kn-aut-mei=侑司 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=トランスサイレチン型心アミロイドーシス患者の心筋組織における微小石灰化と、骨代謝の亢進に関連しないピロリン酸シンチグラフィの集積 kn-title=Microcalcification and 99mTc-Pyrophosphate Uptake without Increased Bone Metabolism in Cardiac Tissue from Patients with Transthyretin Cardiac Amyloidosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MORIAtsushi en-aut-sei=MORI en-aut-mei=Atsushi kn-aut-name=森淳史 kn-aut-sei=森 kn-aut-mei=淳史 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=リウマチ患者の母指ボタン穴変形に対するMCP人工関節置換術においてAVANTAシリコンインプラントは高率に折損する kn-title=High Fracture Rate of AVANTA Silicone Implant Following Arthroplasty of the Thumb MCP Joint of Rheumatoid Arthritis Patients with Boutonniere Deformities en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KANEDADaisuke en-aut-sei=KANEDA en-aut-mei=Daisuke kn-aut-name=兼田大輔 kn-aut-sei=兼田 kn-aut-mei=大輔 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=化学療法を受ける大腸がん患者の手指に生じる末梢神経障害の特徴―横断的観察研究― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YASUDAChika en-aut-sei=YASUDA en-aut-mei=Chika kn-aut-name=安田千香 kn-aut-sei=安田 kn-aut-mei=千香 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=慢性腎臓病患者の病気認知パターンと病気認知パターンにおけるセルフケア行動の違いの検討 kn-title=Identification of illness representational patterns and examining differences of self-care behavior in the patterns in chronic kidney disease en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KAJIWARAYuki en-aut-sei=KAJIWARA en-aut-mei=Yuki kn-aut-name=梶原右揮 kn-aut-sei=梶原 kn-aut-mei=右揮 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肝臓のShear wave dispersion slpoeは肺高血圧症患者の予後を予測し得る kn-title=Shear Wave Dispersion Slope of the Liver Can Predict Adverse Outcomes in Patients with Pulmonary Hypertension　 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=URABEChikara en-aut-sei=URABE en-aut-mei=Chikara kn-aut-name=卜部力 kn-aut-sei=卜部 kn-aut-mei=力 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=欠神発作を示す日本人てんかん患者のGABRA1遺伝子、GABRB2遺伝子およびGABRG2遺伝子解析 kn-title=Mutation screen of GABRA1, GABRB2 and GABRG2 genes in Japanese patients with absence seizures en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ItoMinako en-aut-sei=Ito en-aut-mei=Minako kn-aut-name=伊藤美奈子 kn-aut-sei=伊藤 kn-aut-mei=美奈子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=心不全患者の血圧による細胞外水分量の違い kn-title=Differences in extracellular fluid volume between acute heart failure patients with and without high systolic blood pressure en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NAMBAYusuke en-aut-sei=NAMBA en-aut-mei=Yusuke kn-aut-name=難波悠介 kn-aut-sei=難波 kn-aut-mei=悠介 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=進行がん患者のせん妄に対するリスペリドンと比較したペロスピロンの安全性と有効性：サイコオンコロジーの臨床現場における多施設共同前向き観察研究) kn-title=Safety and effectiveness of perospirone in comparison to risperidone for treatment of delirium in patients with advanced cancer：A multicenter prospective observational study in real-world psycho-oncology settings en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=InoueShinichiro en-aut-sei=Inoue en-aut-mei=Shinichiro kn-aut-name=井上真一郎 kn-aut-sei=井上 kn-aut-mei=真一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=年齢によって異なるインフルエンザ患者の臨床特徴：瀬戸内マリンエリアにおける多施設共同前向き研究 kn-title=Clinical Manifestations of Patients with Influenza Differ by Age: A Prospective, Multi-centered Study in the Setouchi Marine Area en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakaseRyosuke en-aut-sei=Takase en-aut-mei=Ryosuke kn-aut-name=髙瀬了輔 kn-aut-sei=髙瀬 kn-aut-mei=了輔 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=酸素吸入はバルーン肺動脈拡張術前の慢性血栓塞栓性肺高血圧症患者の肺動脈を選択的に拡張する kn-title=Oxygen inhalation can selectively dilate pulmonary arteries in patients with chronic thromboembolic pulmonary hypertension before balloon angioplasty en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShigetoshiMasataka en-aut-sei=Shigetoshi en-aut-mei=Masataka kn-aut-name=重歳正尚 kn-aut-sei=重歳 kn-aut-mei=正尚 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本語版Patient-rated elbow evaluationは、人工肘関節全置換術を受けた関節リウマチ患者の手指機能を反映する可能性のある有用なアウトカム指標である kn-title=Japanese version of Patient-Rated Elbow Evaluation is a useful outcome measure that potentially reflects hand function in patients with rheumatoid arthritis who underwent total elbow arthroplasty en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HarataRyozo en-aut-sei=Harata en-aut-mei=Ryozo kn-aut-name=原田遼三 kn-aut-sei=原田 kn-aut-mei=遼三 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=膵管内乳頭粘液性腫瘍患者の悪性度評価における液状化検体細胞診を用いた膵液細胞診の有用性 kn-title=The efficacy of pancreatic juice cytology with liquid-based cytology for evaluating malignancy in patients with intraductal papillary mucinous neoplasm en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyamotoKazuya en-aut-sei=Miyamoto en-aut-mei=Kazuya kn-aut-name=宮本和也 kn-aut-sei=宮本 kn-aut-mei=和也 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=脳梗塞患者の回収血栓に認められる4-HNE局所性集積パターンはアテローム血栓性脳塞栓症と関連がある kn-title=4-Hydroxyl-2-Nonenal Localized Expression Pattern in Retrieved Clots is Associated with Large Artery Atherosclerosis in Stroke Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OsakadaYosuke en-aut-sei=Osakada en-aut-mei=Yosuke kn-aut-name=小坂田陽介 kn-aut-sei=小坂田 kn-aut-mei=陽介 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本人IgA腎症患者の唾液マイクロバイオームの特徴と慢性扁桃腺炎患者・潰瘍性大腸炎患者との比較 kn-title=Characterization of salivary microbiome of Japanese IgA nephropathy patients in comparison with chronic tonsillitis and ulcerative colitis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KHASNOBISH Anushka en-aut-sei=KHASNOBISH Anushka en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=2 型糖尿病患者の心血管イベントを予測する新規尿糖鎖バイオマーカー: 5 年間の追跡調査による多施設前向き研究 (U-CARE 研究 2） kn-title=Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients with Type 2 Diabetes: A Multicenter Prospective Study with 5-year Follow up（U-CARE Study 2) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ImamuraMariko en-aut-sei=Imamura en-aut-mei=Mariko kn-aut-name=今村麻理子 kn-aut-sei=今村 kn-aut-mei=麻理子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Integrated pulmonary indexは麻酔後回復室において高リスク患者の呼吸障害の予測を可能にする：前向き観察研究 kn-title=Integrated pulmonary index can predict respiratory compromise in high-risk patients in the post-anesthesia care unit: a prospective, observational study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuroeYasutoshi en-aut-sei=Kuroe en-aut-mei=Yasutoshi kn-aut-name=黒江泰利 kn-aut-sei=黒江 kn-aut-mei=泰利 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=全弓部置換術を施行された患者の急性腎不全発症のリスクファクターおよび人工心肺中の温度管理との関係；単施設後方視的観察研究 kn-title=Factors for Acute Kidney Injury Following Total Arch Replacement and Association with Temperature Management during Cardiopulmonary Bypass: A Single-center Retrospective Observational Study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OmiyaHiroki en-aut-sei=Omiya en-aut-mei=Hiroki kn-aut-name=大宮浩揮 kn-aut-sei=大宮 kn-aut-mei=浩揮 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=133 cd-vols= no-issue=2 article-no= start-page=109 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effectiveness of the National Early Warning Score in the diagnosis of sepsis as defined by Sepsis-3 criteria in cancer patients kn-title=担がん患者のSepsis-3 敗血症診断における早期警告スコアの有用性に関する検討：quick SOFA との比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The third international consensus definition of sepsis (Sepsis-3) recommends the quick sequential organ failure assessment (qSOFA) screening tool in patients with suspected infection. The Early Warning Score (EWS) helps to estimate mortality risk in emergency patients. The National EWS (NEWS) is a bedside score of six routine vital parameters. Few studies have compared qSOFA and NEWS in detecting suspected sepsis in cancer patients, so we compared them as a Sepsis-3 prognostic tool. [Methods] This is a retrospective observational single-center study. The study population consisted of cancer patients who entered the intensive care unit (ICU) between 2014 and 2016 for Sepsis-1 (based on systemic inflammatory response syndrome [SIRS] criteria). We calculated and compared the sensitivity and specificity of qSOFA and NEWS. We performed a receiver operating characteristic (ROC) curve analysis of NEWS in the diagnosis of Sepsis-3. [Results] Of the 62 patients admitted to the ICU for Sepsis-1, 42 had Sepsis-3. For qSOFA, sensitivity was 0.71 and specificity was 0.75. Exploratory analysis using the Youden index suggested that 9 may be the optimal score for NEWS. The sensitivity and specificity of NEWS at 9 points were 0.81 and 0.95, respectively. [Conclusion] We found NEWS to be more accurate than qSOFA in screening for Sepsis-3. en-copyright= kn-copyright= en-aut-name=LiuDan en-aut-sei=Liu en-aut-mei=Dan kn-aut-name=劉丹 kn-aut-sei=劉 kn-aut-mei=丹 aut-affil-num=1 ORCID= en-aut-name=MatsumiJunya en-aut-sei=Matsumi en-aut-mei=Junya kn-aut-name=松三絢弥 kn-aut-sei=松三 kn-aut-mei=絢弥 aut-affil-num=2 ORCID= en-aut-name=SaitaKosuke en-aut-sei=Saita en-aut-mei=Kosuke kn-aut-name=税田絋輔 kn-aut-sei=税田 kn-aut-mei=絋輔 aut-affil-num=3 ORCID= en-aut-name=SatoTetsufumi en-aut-sei=Sato en-aut-mei=Tetsufumi kn-aut-name=佐藤哲文 kn-aut-sei=佐藤 kn-aut-mei=哲文 aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Anesthesia and Intensive Care, National Cancer Center Hospital kn-affil=国立がん研究センター中央病院　麻酔・集中治療科 affil-num=2 en-affil=Department of Anesthesia and Intensive Care, National Cancer Center Hospital kn-affil=国立がん研究センター中央病院　麻酔・集中治療科 affil-num=3 en-affil=Department of Anesthesia and Intensive Care, National Cancer Center Hospital kn-affil=国立がん研究センター中央病院　麻酔・集中治療科 affil-num=4 en-affil=Department of Anesthesia and Intensive Care, National Cancer Center Hospital kn-affil=国立がん研究センター中央病院　麻酔・集中治療科 en-keyword=敗血症（sepsis） kn-keyword=敗血症（sepsis） en-keyword=スクリーニング（screcning） kn-keyword=スクリーニング（screcning） en-keyword=qSOFA kn-keyword=qSOFA en-keyword=EWS kn-keyword=EWS en-keyword=SOFA score kn-keyword=SOFA score END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=舌切除患者の音声改善のために新しく設計した平面型人工舌の有用性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NagatsukaHiroaki en-aut-sei=Nagatsuka en-aut-mei=Hiroaki kn-aut-name=長塚弘亮 kn-aut-sei=長塚 kn-aut-mei=弘亮 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=低アンドロゲン状態にある男性２型糖尿病患者の臨床的特徴 kn-title=Clinical Characteristics of Low Androgen Status in Males with Type 2 Diabetes Mellitus en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HamaharaJun en-aut-sei=Hamahara en-aut-mei=Jun kn-aut-name=浜原潤 kn-aut-sei=浜原 kn-aut-mei=潤 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=レクチンアレイによる新規尿中糖鎖プロファイリングは、IgA腎症患者の腎予後予測バイオマーカーである kn-title=Novel urinary glycan profiling by lectin array serves as the biomarkers for predicting renal prognosis in patients with IgA nephropathy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KawakitaChieko en-aut-sei=Kawakita en-aut-mei=Chieko kn-aut-name=川北智英子 kn-aut-sei=川北 kn-aut-mei=智英子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=同一家系における２人目の乳がん患者の家族性乳がんへの対処過程 kn-title=Coping process against familial breast cancer by second patients within blood relatives en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MoritaKumiko en-aut-sei=Morita en-aut-mei=Kumiko kn-aut-name=森田公美子 kn-aut-sei=森田 kn-aut-mei=公美子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=血清REIC/Dkk-3蛋白濃度による肝癌患者の病勢制御予測 kn-title=Serum REIC/Dickkopf-3 Protein Level Predicts Disease-Free Survival in Patients with Hepatocellular Carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OyamaAtsushi en-aut-sei=Oyama en-aut-mei=Atsushi kn-aut-name=大山淳史 kn-aut-sei=大山 kn-aut-mei=淳史 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=血清マロンジアルデヒド修飾 LDLの値は経皮的冠動脈形成術を施行された急性冠症候群患者の予後を予測する kn-title=Serum malondialdehyde-modified low-density lipoprotein levels on admission predict prognosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AmiokaNaofumi en-aut-sei=Amioka en-aut-mei=Naofumi kn-aut-name=網岡尚史 kn-aut-sei=網岡 kn-aut-mei=尚史 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=血中脂肪酸結合タンパクはPCIを受けた安定狭心症患者の心血管イベントの予測因子となる kn-title=Circulating adipocyte fatty acid-binding protein is a predictor of cardiovascular events in patients with stable angina undergoing percutaneous coronary intervention en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakagiWataru en-aut-sei=Takagi en-aut-mei=Wataru kn-aut-name=髙木航 kn-aut-sei=髙木 kn-aut-mei=航 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=高IgG4血症患者の臨床的および生化学的特徴 kn-title=Clinical and biochemical characteristics of patients having general symptoms with increased serum IgG4 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HasegawaKo en-aut-sei=Hasegawa en-aut-mei=Ko kn-aut-name=長谷川功 kn-aut-sei=長谷川 kn-aut-mei=功 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=高エネルギー外傷患者の入院後投与酸素濃度と背側無気肺形成の関連 kn-title=Relationship between a High-inspired Oxygen Concentration and Dorsal Atelectasis in High-energy Trauma Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IshiiKenzo en-aut-sei=Ishii en-aut-mei=Kenzo kn-aut-name=石井賢造 kn-aut-sei=石井 kn-aut-mei=賢造 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue=1 article-no= start-page=59 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=2019 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ポリドカノール硬化療法が有効であった遺伝性出血性末梢血管拡張症（オスラー病）による難治性鼻出血の2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= 難治性鼻出血をきたす基礎疾患の一つに遺伝性出血性末梢血管拡張症（ Hereditary hemorrhagictelangiectasia：HHT，別名：オスラー病）がある．鼻出血を繰り返していた症例にポリドカノール硬化療法を行い，症状が改善した 2 例を経験したため報告する．症例 1：60 歳代男性．鼻出血を繰り返し，近医で鼻粘膜焼灼を反復したが改善せず当院受診．受診時は毎日鼻出血を繰り返していた．口腔・手指の拡張性小血管病変，胃の末梢血管拡張所見，肝動静脈奇形を認め，HHT と診断した．ポリドカノール硬化療法を実施したところ鼻出血回数は著減した．初回から現在までの 4 年間に計 4 回行い，経過は良好である．症例 2：40 歳代女性．父がHHT と診断されている．鼻出血を週 3 回ほど繰り返すため当院受診．手指・舌の拡張性小血管病変および肝動静脈奇形を認め，HHT と診断した．ポリドカノール硬化療法を 1 回実施し，2 年 7 ヶ月経過した現在も鼻出血なく経過している．簡便な手技で年単位の止血効果が得られ，患者の QOL 向上に寄与するポリドカノール硬化療法は HHT 患者で考慮すべき治療法と考える． en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=假谷彰文 kn-aut-sei=假谷 kn-aut-mei=彰文 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤澤郁 kn-aut-sei=藤澤 kn-aut-mei=郁 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤さやか kn-aut-sei=藤 kn-aut-mei=さやか aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=赤木成子 kn-aut-sei=赤木 kn-aut-mei=成子 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小橋春彦 kn-aut-sei=小橋 kn-aut-mei=春彦 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=竹内彩子 kn-aut-sei=竹内 kn-aut-mei=彩子 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山赤十字病院 affil-num=2 en-affil= kn-affil=岡山赤十字病院 affil-num=3 en-affil= kn-affil=岡山赤十字病院 affil-num=4 en-affil= kn-affil=岡山赤十字病院 affil-num=5 en-affil= kn-affil=岡山赤十字病院 affil-num=6 en-affil= kn-affil=岡山赤十字病院 affil-num=7 en-affil= kn-affil=岡山赤十字病院 affil-num=8 en-affil=岡山赤十字病院 kn-affil= en-keyword=Rendu-Osler-Weber disease kn-keyword=Rendu-Osler-Weber disease en-keyword=hereditary hemorrhagic telangiectasia kn-keyword=hereditary hemorrhagic telangiectasia en-keyword=refractory epistaxis kn-keyword=refractory epistaxis en-keyword=sclerotherapy kn-keyword=sclerotherapy en-keyword=polydocanol kn-keyword=polydocanol END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=2型糖尿病患者の末梢神経障害の実態とその障害が ADLへ及ぼす影響 kn-title=Prevalence of peripheral neuropathy and its impact on activities of daily living in people with type 2 diabetes mellitus en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MI MI THET MON WIN en-aut-sei=MI MI THET MON WIN en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=－腸内細菌叢解析およびメタボローム解析による評価－ kn-title=アルツハイマー型認知症患者の腸内細菌叢によるヒト型モデルマウスの構築とこの構築マウスの認知行動に腸内環境が及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujiiYusuke en-aut-sei=Fujii en-aut-mei=Yusuke kn-aut-name=藤井祐介 kn-aut-sei=藤井 kn-aut-mei=祐介 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IBARA AF studyにおける一般人口における心房細動患者の医療機関への低受診率について kn-title=Low Consultation Rate of General Population With Atrial Fibrillation: From the Ibara-AF Study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsumiHitoaki en-aut-sei=Matsumi en-aut-mei=Hitoaki kn-aut-name=松三博明 kn-aut-sei=松三 kn-aut-mei=博明 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=てんかんを持つ小児患者の福祉制度利用の現状と課題－大学病院小児神経科における実態調査－ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UmenoJunko en-aut-sei=Umeno en-aut-mei=Junko kn-aut-name=梅野潤子 kn-aut-sei=梅野 kn-aut-mei=潤子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=上腕動脈の内膜中膜複合体肥厚は糖尿病患者の冠動脈の動脈硬化と関連する kn-title=Brachial intima-media thickness is associated with coronary artery atherosclerosis in patients with diabetes mellitus en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OnoTamaki en-aut-sei=Ono en-aut-mei=Tamaki kn-aut-name=小野環 kn-aut-sei=小野 kn-aut-mei=環 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=20 article-no= start-page=39 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Difficulties in school life can be seen from the medical records of patients with gender dysphoria kn-title=性別違和をもつ患者の診療録から見える学校生活場面での困難さ en-subtitle= kn-subtitle= en-abstract= kn-abstract= A school should be a place where every child can feel comfortable and safe. We aimed to shed light upon difficulties in school life in children with gender dysphoria (GD) and find a way to support them. We extracted the episodes in school life from the medical records of 59 patients with GD. They suffered from using gender segregated bookbags, school uniforms, swimming wears, and bathrooms. Sex education was not enough for them to understand GD. Children with male-to-female GD were bullied at school more often than those with female-to-male GD. Teachers should take note of children with GD, and should provide necessary supports in their school life, including the facilities and their relationships with their peers. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=天野佑美 kn-aut-sei=天野 kn-aut-mei=佑美 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐々木 新 kn-aut-sei=佐々木 kn-aut-mei= 新 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松本洋輔 kn-aut-sei=松本 kn-aut-mei=洋輔 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大守伊織 kn-aut-sei=大守 kn-aut-mei=伊織 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil=Okayama University hospital Gender Center kn-affil=岡山大学病院ジェンダーセンター affil-num=4 en-affil=Okayama University kn-affil=岡山大学大学院教育学研究科 en-keyword=gender dysphoria kn-keyword=gender dysphoria en-keyword=gender identity disorder kn-keyword=gender identity disorder en-keyword=school education kn-keyword=school education en-keyword=gender and sexual diversity kn-keyword=gender and sexual diversity en-keyword=difficulties kn-keyword=difficulties END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=在宅療養がん患者のターミナル期における訪問看護支援に影響を及ぼす要因の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UchidaFumie en-aut-sei=Uchida en-aut-mei=Fumie kn-aut-name=内田史江 kn-aut-sei=内田 kn-aut-mei=史江 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=電気的除細動抵抗性の心室細動/無脈性心室頻拍成人患者の生存に対するアミオダロンおよびニフェカラントの有効性評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SatoShiho en-aut-sei=Sato en-aut-mei=Shiho kn-aut-name=佐藤志帆 kn-aut-sei=佐藤 kn-aut-mei=志帆 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=食道がん患者の周術期における舌圧減少とICU滞在日数との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MoritaAya en-aut-sei=Morita en-aut-mei=Aya kn-aut-name=森田彩 kn-aut-sei=森田 kn-aut-mei=彩 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=進行肝細胞癌に対するソラフェニブ治療患者の血管新生サイトカインの測定 kn-title=Monitoring serum proangiogenic cytokines from hepatocellular carcinoma patients treated with sorafenib en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AdachiTakuya en-aut-sei=Adachi en-aut-mei=Takuya kn-aut-name=足立卓哉 kn-aut-sei=足立 kn-aut-mei=卓哉 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=短母指伸筋腱の停止様式が関節リウマチ患者の母指ボタン穴変形発症に与える影響 kn-title=A high incidence of extensor pollicis brevis insertion into the distal phalanx in rheumatoid arthritis patients who required the surgical reconstruction for thumb boutonni?re deformity en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkitaShunji en-aut-sei=Okita en-aut-mei=Shunji kn-aut-name=沖田駿治 kn-aut-sei=沖田 kn-aut-mei=駿治 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=視床下核刺激術を施行した、姿勢異常を伴うパーキンソン病患者の特徴とその予後因子の検討 kn-title=Characteristics and prognostic factors of Parkinson’s disease patients with abnormal postures subjected to subthalamic nucleus deep brain stimulation en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkazakiMihoko en-aut-sei=Okazaki en-aut-mei=Mihoko kn-aut-name=岡﨑三保子 kn-aut-sei=岡﨑 kn-aut-mei=三保子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ago2タンパク質に関連した循環マイクロRNA測定を用いた大腸癌化学療法患者の抗腫瘍効果のモニタリング kn-title=Detection of Circulating MicroRNAs with Ago2 Complexes to Monitor the Tumor Dynamics of Colorectal Cancer Patients during Chemotherapy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujiTomokazu en-aut-sei=Fuji en-aut-mei=Tomokazu kn-aut-name=藤智和 kn-aut-sei=藤 kn-aut-mei=智和 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=低リスクドナー肺は、高い肺分配スコア患者の肺移植後の転帰を最適化する kn-title=Low-risk donor lungs optimize the post-lung transplant outcome for high lung allocation score patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurosakiTakeshi en-aut-sei=Kurosaki en-aut-mei=Takeshi kn-aut-name=黒﨑毅史 kn-aut-sei=黒﨑 kn-aut-mei=毅史 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=3-4 article-no= start-page=382 end-page=362 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190319 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Current Issues Surrounding Doctor’s Duty of Responding to Call-up kn-title=応招義務を巡る今日的問題 : 渡航移植患者の受入拒否事例について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShishidoK. en-aut-sei=Shishido en-aut-mei=K. kn-aut-name=宍戸圭介 kn-aut-sei=宍戸 kn-aut-mei=圭介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山商科大学法学部 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180927 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本人アルツハイマー病患者の腸内細菌叢解析とその細菌叢から分離された酪酸産生菌の特徴 kn-title=Analysis of the gut microbiota of Japanese Alzheimer’s disease patients and characterization of their butyrate-producing bacteria en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Nguyen Thi Thuy Tien en-aut-sei=Nguyen Thi Thuy Tien en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180927 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=外来発熱患者の臨床的特徴に関する研究：甲状腺機能の熱性頻脈への関与 kn-title=Clinical Characteristics of Febrile Outpatients: Possible Involvement of Thyroid Dysfunction in Febrile Tachycardia en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkaKosuke en-aut-sei=Oka en-aut-mei=Kosuke kn-aut-name=岡浩介 kn-aut-sei=岡 kn-aut-mei=浩介 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue= article-no= start-page=34 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201711 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=岡山赤十字病院における2016年度の夜間・休日耳鼻咽喉科救急患者の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=当院における耳鼻咽喉科の救急診療の実態について検討した。対象は2016年度に当院救急外来を夜間・休日に受診し、耳鼻咽喉科医の診察を受けた144例である。平均年齢44.6歳(1～94歳)、男性93例、女性51例であった。曜日別検討では、最多は土曜日の43例、次に日曜日の28例であった。平日は15例前後で大きな差は認めなかった。時間帯別検討では、休日日勤帯38例(入院19例、救急搬送6例)、準夜帯88例(入院48例、救急搬送19例)、深夜帯18例(入院13例、救急搬送12例)であった。疾患別検討では、上気道急性炎症が39例(扁桃周囲膿瘍および周囲炎14例、急性扁桃炎10例、急性喉頭蓋炎9例)であり、続いて異物30例、外傷22例、鼻出血17例の順であった。救急搬送された症例は144例中37例(外傷10例、上気道急性炎症6例、鼻出血7例)であった。当院をとりまく医療環境は変化しており、地域の実情に対応した耳鼻咽喉科救急医療体制が必要と思われた。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name= 石原久司 kn-aut-sei= 石原 kn-aut-mei=久司 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name= 藤澤郁 kn-aut-sei= 藤澤 kn-aut-mei=郁 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=竹内彩子 kn-aut-sei=竹内 kn-aut-mei=彩子 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name= 赤木成子 kn-aut-sei= 赤木 kn-aut-mei=成子 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山赤十字病院 耳鼻咽喉科 affil-num=2 en-affil= kn-affil=岡山赤十字病院 耳鼻咽喉科 affil-num=3 en-affil= kn-affil=岡山赤十字病院 耳鼻咽喉科 affil-num=4 en-affil= kn-affil=岡山赤十字病院 耳鼻咽喉科 affil-num=5 en-affil= kn-affil=岡山赤十字病院 耳鼻咽喉科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=冠動脈疾患患者の雑音低減技術による放射線量低下時の画質の検討 kn-title=Image Quality of the Coronary Angiography with Noise Reduction Technology to Decrease the Radiation Dose en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KumashiroMasayuki en-aut-sei=Kumashiro en-aut-mei=Masayuki kn-aut-name=熊代正行 kn-aut-sei=熊代 kn-aut-mei=正行 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=乳がん患者の性生活 : 治療に伴う変化に対するコーピング kn-title=The sexual lives of breast cancer patients: Coping with changes associated with treatment en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YoshikawaAyumi en-aut-sei=Yoshikawa en-aut-mei=Ayumi kn-aut-name=吉川あゆみ kn-aut-sei=吉川 kn-aut-mei=あゆみ aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=運動負荷試験はBrugada症候群患者の隠れたS-ICD不適合性を明らかにする kn-title=Exercise stress test reveals ineligibility for subcutaneous implantable cardioverter defibrillator in patients with Brugada syndrome en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TachibanaMotomi en-aut-sei=Tachibana en-aut-mei=Motomi kn-aut-name=橘元見 kn-aut-sei=橘 kn-aut-mei=元見 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=関節リウマチ患者の前足部変形に対する切除関節形成術と関節温存手術の治療成績 kn-title=Outcomes of resection and joint-preserving arthroplasty for forefoot deformities in patients with rheumatoid arthritis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HoritaMasahiro en-aut-sei=Horita en-aut-mei=Masahiro kn-aut-name=堀田昌宏 kn-aut-sei=堀田 kn-aut-mei=昌宏 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=2 article-no= start-page=93 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The development of a scale to measure stress recognition during the treatment of diabetes patients kn-title=糖尿病患者の「治療に伴うストレス認知尺度」の開発 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　The purpose of this study was to establish a measurement scale for "stress recognition in receiving treatment" in patients with diabetes. A self-completed questionnaire was distributed to 149 type-2 diabetes outpatients in March-May 2015 after authorization from Okayama Prefectural University and the ethics committee of the hospital. 　The "stress recognition in receiving treatment" scale was designed as a second-order factor model consisting of 14 items and the following four factors : the respondent's sense of (1) the burden of being sick, (2) the burden on interpersonal relationships, (3) the burden of treatment, and (4) the burden of medical expenses. 　Stress recognition in treatment means recognition of being stressed in the burdens related to the illness, interpersonal relationships, treatment and medical expenses. 　The suitability of the questionnaire data was then evaluated with a structural equation model. The suitability of the factor model to the data satisfied the statistically acceptable standards as Comparative Fit Index (CFI) ＝0.931, Root Mean Square Error of Approximation (RMSEA) ＝0.096, Tucker-Lewis Index (TLI) ＝0.946. 　As the construct validity was not examined by the scale created in this study or by existing scale, it was verified by using the degrees of mental healthiness and HbA1c that were proved to be associated with the sense of burden. 　In addition, the construct validity of the questionnaire was supported by a significant correlation between the Japanese version of the WHO-Five Well-being Index (S-WHO-5-J) and the patients' HbA1c levels. The use of this measure is expected to contribute to the early detection of a decline in a diabetic patient's activities of daily living and to the early confirmation of patients' support status. en-copyright= kn-copyright= en-aut-name=SumiyoshiKazuko en-aut-sei=Sumiyoshi en-aut-mei=Kazuko kn-aut-name=住吉和子 kn-aut-sei=住吉 kn-aut-mei=和子 aut-affil-num=1 ORCID= en-aut-name=KawataChieko en-aut-sei=Kawata en-aut-mei=Chieko kn-aut-name=川田智恵子 kn-aut-sei=川田 kn-aut-mei=智恵子 aut-affil-num=2 ORCID= en-aut-name=OkamotoTatsuo en-aut-sei=Okamoto en-aut-mei=Tatsuo kn-aut-name=岡本辰夫 kn-aut-sei=岡本 kn-aut-mei=辰夫 aut-affil-num=3 ORCID= en-aut-name=OhashiMutsuko en-aut-sei=Ohashi en-aut-mei=Mutsuko kn-aut-name=大橋睦子 kn-aut-sei=大橋 kn-aut-mei=睦子 aut-affil-num=4 ORCID= en-aut-name=MikaneSakae en-aut-sei=Mikane en-aut-mei=Sakae kn-aut-name=實金栄 kn-aut-sei=實金 kn-aut-mei=栄 aut-affil-num=5 ORCID= en-aut-name=TakabayashiNoriko en-aut-sei=Takabayashi en-aut-mei=Noriko kn-aut-name=高林範子 kn-aut-sei=高林 kn-aut-mei=範子 aut-affil-num=6 ORCID= en-aut-name=FutoyuYoshiko en-aut-sei=Futoyu en-aut-mei=Yoshiko kn-aut-name=太湯好子 kn-aut-sei=太湯 kn-aut-mei=好子 aut-affil-num=7 ORCID= en-aut-name=KimWoesook en-aut-sei=Kim en-aut-mei=Woesook kn-aut-name=金外淑 kn-aut-sei=金 kn-aut-mei=外淑 aut-affil-num=8 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name=和田淳 kn-aut-sei=和田 kn-aut-mei=淳 aut-affil-num=9 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name=四方賢一 kn-aut-sei=四方 kn-aut-mei=賢一 aut-affil-num=10 ORCID= en-aut-name=NakajimaKazuo en-aut-sei=Nakajima en-aut-mei=Kazuo kn-aut-name=中嶋和夫 kn-aut-sei=中嶋 kn-aut-mei=和夫 aut-affil-num=11 ORCID= affil-num=1 en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University kn-affil=岡山県立大学　保健福祉学部 affil-num=2 en-affil=Health and Nursing Sciences Masters Program, Wakayama Medical University kn-affil=和歌山県立医科大学　大学院保健看護学研究科 affil-num=3 en-affil=Ryobi General Research Institute of Community Care kn-affil=両備地域ケア総合研究所 affil-num=4 en-affil=Department of Nursing, Okayama University Hospital kn-affil=岡山大学病院 看護部 affil-num=5 en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University kn-affil=岡山県立大学　保健福祉学部 affil-num=6 en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University kn-affil=岡山県立大学　保健福祉学部 affil-num=7 en-affil=School of Health Science and Social Welfare, Kibi International University kn-affil=吉備国際大学　保健医療福祉学部 affil-num=8 en-affil=College of Nursing Art and Science, University of Hyogo kn-affil=兵庫県立大学　看護学部 affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=10 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=岡山大学病院　新医療研究開発センター affil-num=11 en-affil=Ryobi General Research Institute of Community Care kn-affil=両備地域ケア総合研究所 en-keyword=糖尿病患者 (diabetes patients) kn-keyword=糖尿病患者 (diabetes patients) en-keyword=治療 (treatment) kn-keyword=治療 (treatment) en-keyword=ストレス認知 (stress recognition) kn-keyword=ストレス認知 (stress recognition) en-keyword=尺度開発 (development of a scale) kn-keyword=尺度開発 (development of a scale) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=白内障術前患者の結膜嚢内細菌検査が陽性となる臨床的要因と糖尿病との関連 kn-title=Positive bacterial culture in conjunctival sac before cataract surgery with night stay is related to diabetes mellitus en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KawataTetsuhiro en-aut-sei=Kawata en-aut-mei=Tetsuhiro kn-aut-name=河田哲宏 kn-aut-sei=河田 kn-aut-mei=哲宏 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The process of initial treatment choice among female patients with breast cancer who received a second opinion kn-title=セカンドオピニオンを受けた女性乳がん患者の初期治療選択過程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuiMiyuki en-aut-sei=Matsui en-aut-mei=Miyuki kn-aut-name=松井美由紀 kn-aut-sei=松井 kn-aut-mei=美由紀 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=患者の健康状態と療養環境の違いによる手指衛生の有効性 kn-title=The effectiveness of hand hygiene depends on the patient’s health condition and care environment en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YanoJunko en-aut-sei=Yano en-aut-mei=Junko kn-aut-name=矢野淳子 kn-aut-sei=矢野 kn-aut-mei=淳子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=筋・筋膜痛患者の歯根膜感覚閾値と咬筋筋活動時間についての研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HirataAtsutoshi en-aut-sei=Hirata en-aut-mei=Atsutoshi kn-aut-name=平田敦俊 kn-aut-sei=平田 kn-aut-mei=敦俊 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=3 article-no= start-page=203 end-page=207 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20151201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Non-high-output cardiac failure in patients undergoing hemodialysis through an arteriovenous shunt kn-title=透析シャント心不全―非過大シャント心不全 “Non-High-Output Cardiac Failure”の病態― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Hemodialysis-related heart failure has been considered to be associated with excessive blood flow through the arteriovenous (AV) shunt used for vascular access. However, some patients undergoing dialysis have heart failure in the absence of an increase in cardiac output (CO) related to shunt blood-flow loading because the loading cannot be compensated for by increasing CO. This condition may be challenging to manage ; thus, early diagnosis is important. Methods and Results: Twelve patients (mean age, 71 years ; 9 men) with end-stage renal disease, dialysis-related heart failure, a high brain natriuretic peptide (BNP) level, and a mean New York Heart Association (NYHA) class of II underwent AV shunt closure. Their cardiac index (CI), pre- and post-dialysis BNP levels, and several cardiac variables were assessed pre- and postoperatively. All patients achieved relief of heart failure symptoms and a reduction in NYHA class after AV closure, but six patients had a postoperative increase in CI (the "non-high-output" cardiac failure group), whereas the other six had a decrease in CI (the "high-output" cardiac failure group). The high-output patients had greater improvements in BNP levels and most cardiac variables compared to the non-high-output group ; therefore, the heart failure in the non-high-output patients was considered more serious than that in the high-output group. Conclusions: The selection of effective strategies for treating dialysis-related heart failure may depend partly on identifying which patients have non-high-output failure. Such identification requires serial measurements of BNP levels and evaluations of cardiac variables other than the ejection fraction. en-copyright= kn-copyright= en-aut-name=UgawaToyomu en-aut-sei=Ugawa en-aut-mei=Toyomu kn-aut-name=鵜川豊世武 kn-aut-sei=鵜川 kn-aut-mei=豊世武 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 en-keyword=心拍出量（cardiac output） kn-keyword=心拍出量（cardiac output） en-keyword=心不全（heart failure） kn-keyword=心不全（heart failure） en-keyword=脳性ナトリウム利尿ペプチド（brain natriuretic peptide） kn-keyword=脳性ナトリウム利尿ペプチド（brain natriuretic peptide） en-keyword=非過大シャント心不全（non-high-output cardiac failure） kn-keyword=非過大シャント心不全（non-high-output cardiac failure） en-keyword=腎臓（kidney） kn-keyword=腎臓（kidney） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=無症候性PBC患者の予後不良例の早期発見におけるケラチン7染色の有用性 kn-title=Aberrant Expression of Keratin 7 in Hepatocytes as a Predictive Marker of Rapid Progression to Hepatic Failure in Asymptomatic Primary Biliary Cirrhosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SekiHiroyuki en-aut-sei=Seki en-aut-mei=Hiroyuki kn-aut-name=關博之 kn-aut-sei=關 kn-aut-mei=博之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=サイトメガロウイルス血中抗原検査に基づいて治療された潰瘍性大腸炎患者の長期経過観察 kn-title=Long-term follow-up of ulcerative colitis patients treated on the basis of their cytomegalovirus antigen status en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name=井口俊博 kn-aut-sei=井口 kn-aut-mei=俊博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cholelithiasis with a cholecystoduodenal fistula complicated with paroxysmal nocturnal hemoglobinuria kn-title=胆嚢十二指腸瘻に対し合併症なく手術を行えた発作性夜間血色素尿症の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　In cases of paroxysmal nocturnal hemoglobinuria (PNH), attention must be paid to potential complications such as thrombosis and hemolysis due to perioperative stress and infection from complement activation. Here we present the case of a 61-year-old Japanese woman with PNH. We made the diagnosis of PNH when she was 28 years old, and we administered repeated steroid medication and erythrocyte transfusion. The patient's cholecystocholedocholithiasis with a cholecystoduodenal fistula was diagnosed based on a survey of the right hypochondriac pain. We performed endoscopic nasobiliary drainage (ENBD) for the prophylaxis of perioperative infection, plus a cholecystectomy and fistulectomy. There were no complications, including hemolysis attack, infection, thrombosis with irrigation erythrocyte transfusion, steroid cover, or the need for heparin administration during the perioperative period. The reduction of the complement activation is necessary in the perioperative management of PNH patients. The prevention of the development of acidosis and hypoxemia, the selection of washed red blood cells, steroid use, appropriate infection measures and thrombosis prophylaxis are all important for the prevention of complications. en-copyright= kn-copyright= en-aut-name=KatoTakuya en-aut-sei=Kato en-aut-mei=Takuya kn-aut-name=加藤卓也 kn-aut-sei=加藤 kn-aut-mei=卓也 aut-affil-num=1 ORCID= en-aut-name=MatsukawaHiroyoshi en-aut-sei=Matsukawa en-aut-mei=Hiroyoshi kn-aut-name=松川啓義 kn-aut-sei=松川 kn-aut-mei=啓義 aut-affil-num=2 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=塩崎滋弘 kn-aut-sei=塩崎 kn-aut-mei=滋弘 aut-affil-num=3 ORCID= en-aut-name=FujiTomokazu en-aut-sei=Fuji en-aut-mei=Tomokazu kn-aut-name=藤智和 kn-aut-sei=藤 kn-aut-mei=智和 aut-affil-num=4 ORCID= en-aut-name=FujiwaraYasuhiro en-aut-sei=Fujiwara en-aut-mei=Yasuhiro kn-aut-name=藤原康宏 kn-aut-sei=藤原 kn-aut-mei=康宏 aut-affil-num=5 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=二宮基樹 kn-aut-sei=二宮 kn-aut-mei=基樹 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=2 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil= kn-affil=広島市立広島市民病院　外科 en-keyword=発作性夜間血色素尿症（PNH）（paroxysmal nocturnal hemoglobinuria (PNH)） kn-keyword=発作性夜間血色素尿症（PNH）（paroxysmal nocturnal hemoglobinuria (PNH)） en-keyword=胆嚢十二指腸瘻（cholecystoduodenal fistula） kn-keyword=胆嚢十二指腸瘻（cholecystoduodenal fistula） en-keyword=溶血発作（hemolysis） kn-keyword=溶血発作（hemolysis） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=脂質異常症患者のインスリン抵抗性および心臓手術患者の術後経過に対するエイコサペンタエン酸の保護効果：アディポネクチン関与の可能性 kn-title=Protective Effect of Eicosapentaenoic Acid on Insulin Resistance in Hyperlipidemic Patients and on the Postoperative Course of Cardiac Surgery Patients: The Possible Involvement of Adiponectin en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamamotoTsuyoshi en-aut-sei=Yamamoto en-aut-mei=Tsuyoshi kn-aut-name=山本剛 kn-aut-sei=山本 kn-aut-mei=剛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=関節リウマチ患者のMRI評価： 生物学的製剤投与患者評価におけるOMERACT (Outcome Measures in Rheumatology Clinical Trials) スコアシステム評価と滑膜体積の比較 kn-title=MRI of Rheumatoid Arthritis: Comparing the Outcome Measures in Rheumatology Clinical Trials (OMERACT) Scoring and Volume of Synovitis for the Assessment of Biologic Therapy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakaharaRyuichi en-aut-sei=Nakahara en-aut-mei=Ryuichi kn-aut-name=中原龍一 kn-aut-sei=中原 kn-aut-mei=龍一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=2型糖尿病患者の尿中アンジオテンシノーゲンは尿細管障害のマーカーである kn-title=Urinary angiotensinogen is a marker for tubular injuries in patients with type 2 diabetes en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TeramiTakahiro en-aut-sei=Terami en-aut-mei=Takahiro kn-aut-name=寺見隆宏 kn-aut-sei=寺見 kn-aut-mei=隆宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=159 end-page=163 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (30. combination with therapeutic drugs for chronic pain) kn-title=薬物相互作用 (30―慢性疼痛治療薬の相互作用） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OgawaAtsushi en-aut-sei=Ogawa en-aut-mei=Atsushi kn-aut-name=小川敦 kn-aut-sei=小川 kn-aut-mei=敦 aut-affil-num=1 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name=北村佳久 kn-aut-sei=北村 kn-aut-mei=佳久 aut-affil-num=2 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=2 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=3 en-affil= kn-affil=岡山大学病院　薬剤部 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=133 end-page=135 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Treatment for a non-compliant patient with cancer and epilepsy kn-title=癌告知後の精神症状の治療に難渋したてんかん既往のある癌患者の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 58-year-old man with cervical esophageal cancer and a history of epilepsy was treated with chemoradiotherapy from May of 2013. When tube feeding was initiated due to aspiration pneumonitis, the patient showed a degree of irritability that affected routine staff work and treatment compliance. We attempted to perform supportive care for maladjustment by the notice, the fast, and the tube feeding, but there was no improvement. After we added carbamazepine, primidone, and propericiazine (which had been canceled at the initiation of the tube feeding) to the patient's intravenous phenytoin, the symptoms and treatment compliance improved significantly. We concluded that the causes of the patient's irritability were maladjustment and his epilepsy. en-copyright= kn-copyright= en-aut-name=MinamiDaisuke en-aut-sei=Minami en-aut-mei=Daisuke kn-aut-name=南大輔 kn-aut-sei=南 kn-aut-mei=大輔 aut-affil-num=1 ORCID= en-aut-name=IchiharaEiki en-aut-sei=Ichihara en-aut-mei=Eiki kn-aut-name=市原英基 kn-aut-sei=市原 kn-aut-mei=英基 aut-affil-num=2 ORCID= en-aut-name=OkabeNobuyuki en-aut-sei=Okabe en-aut-mei=Nobuyuki kn-aut-name=岡部伸幸 kn-aut-sei=岡部 kn-aut-mei=伸幸 aut-affil-num=3 ORCID= en-aut-name=YokomichiNaosuke en-aut-sei=Yokomichi en-aut-mei=Naosuke kn-aut-name=横道直佑 kn-aut-sei=横道 kn-aut-mei=直佑 aut-affil-num=4 ORCID= en-aut-name=KougeNoriko en-aut-sei=Kouge en-aut-mei=Noriko kn-aut-name=高下典子 kn-aut-sei=高下 kn-aut-mei=典子 aut-affil-num=5 ORCID= en-aut-name=KajizonoMakoto en-aut-sei=Kajizono en-aut-mei=Makoto kn-aut-name=鍛治園誠 kn-aut-sei=鍛治園 kn-aut-mei=誠 aut-affil-num=6 ORCID= en-aut-name=AkimotoYutaka en-aut-sei=Akimoto en-aut-mei=Yutaka kn-aut-name=秋元悠 kn-aut-sei=秋元 kn-aut-mei=悠 aut-affil-num=7 ORCID= en-aut-name=HoriKeisuke en-aut-sei=Hori en-aut-mei=Keisuke kn-aut-name=堀圭介 kn-aut-sei=堀 kn-aut-mei=圭介 aut-affil-num=8 ORCID= en-aut-name=MatsubaraMinoru en-aut-sei=Matsubara en-aut-mei=Minoru kn-aut-name=松原稔 kn-aut-sei=松原 kn-aut-mei=稔 aut-affil-num=9 ORCID= en-aut-name=NasuJunichiro en-aut-sei=Nasu en-aut-mei=Junichiro kn-aut-name=那須淳一郎 kn-aut-sei=那須 kn-aut-mei=淳一郎 aut-affil-num=10 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=11 ORCID= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=12 ORCID= en-aut-name=MatsuokaJunzi en-aut-sei=Matsuoka en-aut-mei=Junzi kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　緩和支持医療科 affil-num=2 en-affil= kn-affil=岡山大学病院　血液・腫瘍・呼吸器内科 affil-num=3 en-affil= kn-affil=岡山大学病院　精神科神経科 affil-num=4 en-affil= kn-affil=岡山大学病院　緩和支持医療科 affil-num=5 en-affil= kn-affil=岡山大学病院　看護部 affil-num=6 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=7 en-affil= kn-affil=岡山大学病院　消化器内科 affil-num=8 en-affil= kn-affil=岡山大学病院　消化器内科 affil-num=9 en-affil= kn-affil=岡山大学病院　消化器内科 affil-num=10 en-affil= kn-affil=岡山大学病院　消化器内科 affil-num=11 en-affil= kn-affil=岡山大学病院　血液・腫瘍・呼吸器内科 affil-num=12 en-affil= kn-affil=岡山大学病院　血液・腫瘍・呼吸器内科 affil-num=13 en-affil= kn-affil=岡山大学病院　緩和支持医療科 en-keyword=てんかん（epilepsy） kn-keyword=てんかん（epilepsy） en-keyword=易怒性（irritability） kn-keyword=易怒性（irritability） en-keyword=適応障害（maladjustment） kn-keyword=適応障害（maladjustment） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=外来外照射療法開始前のがん患者が必要とする情報と患者の内的世界 ―患者のセルフケアを促進する治療開始前の看護支援の検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurodaSumie en-aut-sei=Kuroda en-aut-mei=Sumie kn-aut-name=黒田寿美恵 kn-aut-sei=黒田 kn-aut-mei=寿美恵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=矯正歯科治療患者の口腔関連Quality of Lifeの評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KomoriHiroki en-aut-sei=Komori en-aut-mei=Hiroki kn-aut-name=古森紘基 kn-aut-sei=古森 kn-aut-mei=紘基 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=テストステロン置換療法はGIDのFTM患者の血清尿酸値を上げる kn-title=Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurahashiHiroaki en-aut-sei=Kurahashi en-aut-mei=Hiroaki kn-aut-name=倉橋寛明 kn-aut-sei=倉橋 kn-aut-mei=寛明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=5 article-no= start-page=1200 end-page=1207 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199209 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=脳卒中片麻痺患者の骨塩量とその意義に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=片麻痺患者131例の全身及び第2～4腰椎の骨塩量をDEXAにて測定した。a)麻痺側の上肢下肢のみ骨塩量の減少を認めた。b)健側の上肢,下肢,腰椎の骨塩量には有意の変化はなかった。c)骨塩量の減少は下肢よりも上皮,男よりも女にきたしやすかった。d)発症後1ヵ月以上,Br. stage 4以下の例は有意に骨塩量が減少していた。2)骨萎縮防止のため早期のリハビリテーション開始と歩行能力の獲得が大切であると考えられた en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=吉村一穂 kn-aut-sei=吉村 kn-aut-mei=一穂 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=血清可溶型Klothoの低下は慢性腎臓病患者の動脈スティフネスを規定する独立したバイオマーカーである kn-title=A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KitagawaMasashi en-aut-sei=Kitagawa en-aut-mei=Masashi kn-aut-name=北川正史 kn-aut-sei=北川 kn-aut-mei=正史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=緩和ケア病棟入院中で余命3週間程度と予測されている終末期がん患者の1日の過ごし方に対する意思決定の内容 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=EguchiHitomi en-aut-sei=Eguchi en-aut-mei=Hitomi kn-aut-name=江口瞳 kn-aut-sei=江口 kn-aut-mei=瞳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=55歳またはそれ以上の高齢で診断された無症候性原発性胆汁性肝硬変患者の死亡率は健常人の死亡率と同等である kn-title=Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KubotaJunichi en-aut-sei=Kubota en-aut-mei=Junichi kn-aut-name=窪田淳一 kn-aut-sei=窪田 kn-aut-mei=淳一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=潰瘍性大腸炎患者の大腸粘膜におけるDNAメチル化について：その炎症状態との関連 kn-title=DNA Methylation of Colon Mucosa in Ulcerative Colitis Patients: Correlation with Inflammatory Status en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SaitoShunsuke en-aut-sei=Saito en-aut-mei=Shunsuke kn-aut-name=齊藤俊介 kn-aut-sei=齊藤 kn-aut-mei=俊介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=岡山大学病院における不明熱患者の検討：原因疾患の特徴と検査の有用性の解析 kn-title=A Comprehensive Analysis of 174 Febrile Patients Admitted to Okayama University Hospital en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=RyukoHiromasa en-aut-sei=Ryuko en-aut-mei=Hiromasa kn-aut-name=立古浩雅 kn-aut-sei=立古 kn-aut-mei=浩雅 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=喉頭全摘術を受ける頭頸部がん患者の術前から退院後１年間の他者とのコミュニケーションを通したコミュニケーション方法の再構築過程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamauchiEiko en-aut-sei=Yamauchi en-aut-mei=Eiko kn-aut-name=山内栄子 kn-aut-sei=山内 kn-aut-mei=栄子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=筋ジストロフィー患者の個人の生活の質評価法における当事者視点の導入とその意義 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HukudaMari en-aut-sei=Hukuda en-aut-mei=Mari kn-aut-name=福田茉莉 kn-aut-sei=福田 kn-aut-mei=茉莉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=再灌流療法を受けた急性心筋梗塞患者の入浴による生体反応 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HigoSumiko en-aut-sei=Higo en-aut-mei=Sumiko kn-aut-name=肥後すみ子 kn-aut-sei=肥後 kn-aut-mei=すみ子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=少量のミダゾラム投与による高血圧歯科患者の血圧安定化効果—二重盲検ランダム化比較試験— en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeYoshihisa en-aut-sei=Watanabe en-aut-mei=Yoshihisa kn-aut-name=渡辺禎久 kn-aut-sei=渡辺 kn-aut-mei=禎久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=訪問診療患者の在宅死成立因子の研究：在宅療養支援診療所の後ろ向きコホート研究 kn-title=Study on the factors determining home death of patients during home care: A historical cohort study at a home care support clinic en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KawagoeSeiji en-aut-sei=Kawagoe en-aut-mei=Seiji kn-aut-name=川越誠志 kn-aut-sei=川越 kn-aut-mei=誠志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=血清シアル化糖蛋白KL-6上昇はゲフィチニブで治療された非小細胞肺癌患者の予後不良因子である kn-title=Elevated serum level of sialylated glycoprotein KL-6 predicts a poor prognosis in patients with non-small cell lung cancer treated with gefitinib en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HujiwaraYoshirou en-aut-sei=Hujiwara en-aut-mei=Yoshirou kn-aut-name=藤原義朗 kn-aut-sei=藤原 kn-aut-mei=義朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺静脈閉塞症患者および肺毛細血管腫症患者の胸部高分解能CTにおける小葉中心性すりガラス様陰影サイズの違い kn-title=Different sizes of centrilobular ground-glass opacities in chest high-resolution computed tomography of patients with pulmonary veno-occlusive disease and patients with pulmonary capillary hemangiomatosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiuraAya en-aut-sei=Miura en-aut-mei=Aya kn-aut-name=三浦綾 kn-aut-sei=三浦 kn-aut-mei=綾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ロサルタン/ヒドロクロロチアジドは高用量ARBより早朝高血圧患者の早朝家庭血圧の降圧において優れる kn-title=Losartan/Hydrochlorothiazide Combination Therapy Surpasses High-dose Angiotensin Receptor Blocker in the Reduction of Morning Home Blood Pressure in Patients with Morning Hypertension en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HanayamaYoshihisa en-aut-sei=Hanayama en-aut-mei=Yoshihisa kn-aut-name=花山宜久 kn-aut-sei=花山 kn-aut-mei=宜久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120927 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=食道切除術後の回復過程において補助療法を受けた患者の術後生活再構築課程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MoriKeiko en-aut-sei=Mori en-aut-mei=Keiko kn-aut-name=森恵子 kn-aut-sei=森 kn-aut-mei=恵子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=顎変形症患者の手術後の咀嚼機能評価に関する検討－主観的評価と客観的評価の相関性について－ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OnoYuko en-aut-sei=Ono en-aut-mei=Yuko kn-aut-name=尾野裕子 kn-aut-sei=尾野 kn-aut-mei=裕子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=人工網膜手術の対象である網膜色素変性患者の視力に関連した客観的指標としての光干渉断層計所見 kn-title=Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NawataMiho en-aut-sei=Nawata en-aut-mei=Miho kn-aut-name=縄田美帆 kn-aut-sei=縄田 kn-aut-mei=美帆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=膀胱尿路上皮内癌患者のp16,pRbおよびp53の発現様式とBCG膀胱注入療法に対する応答との関連性 kn-title=Association between the expression pattern of p16, pRb and p53 and the response to intravesical bacillus Calmette-Guerin therapy in patients with urothelial carcinoma in situ of the urinary bladder en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SatoMasakazu en-aut-sei=Sato en-aut-mei=Masakazu kn-aut-name=佐藤正和 kn-aut-sei=佐藤 kn-aut-mei=正和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=1-2 suppl article-no= start-page=29 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Seasonal Distribution of Mosquitoes and the Incidence of Japanese B Encephalitis in Okayama Prefecture during 1979 kn-title=1979年岡山県下における蚊の出現状態と 日本脳炎発生状況について en-subtitle= kn-subtitle= en-abstract=Mosquito collections were done at nine spots in Okayama Prefecture twice a week from April till September in 1979. The day-light type light-trap was used for the mosquito collection and the trap was set all night long. 1. The mean temperature of the day became higher than the average one after June and was higher than 25℃ for 40 days from July 19 till August 28. The term was 20 days shorter than that of last year. The rainly season lasted from June 6 till July 25. Typhoon No. 11 passed bv Okayama Prefecture in August and No.12 & No. 16 in September. 2. The numbers of collected Culex pipiens pallens were more than those of last year at Okayama (1.5 times). Seto (1.3 times). Nariwa (1.6 times) and Tsuyama (3.4 times) respectively. While the numbers decreased at Kurashiki and Niimi (1/2 time). 3. The numbers of collected Culex tritaeniorhynchus increased comparing to those of last year at Kasaoka (3.5 times). Seto (2.9 times), Nariwa (1.3 times) and Niimi (5 times). While they decreased at Kurashiki (1/1.1 time) and Okayama (1/1.6 time). 4. In Anopheles sinensis the collected numbers decreased comparing to those of last year at Kurashiki (1/2 time) and Seto (1/1.5 time). Only three femal and three male mosquitoes were caught at Okayama, one female at Saidaiji, and no Anopheles sinensis was caught at the compus of Okayama University Medical School. 5. The numbers of collected mosquitoes were very few at Saidaiji (where mosquito collection was started newly from 1979) and Okayama University Medical School. 6. The collected numbers in all Culex pipiens pallens. Culex tritaeniorhynchus and Anopheles sinensis increased at Kasaoka, Nariwa and Tsuyama. While the numbers in all these three species decreased at Kurashiki. At Seto the numbers of collected mosquitoes increased only in Culex pipiens pallens and Culex tritaeniorhynchus. 7. There was no human case of Japanese B encephalitis in 1979. kn-abstract=県下9ヶ所の定点において，light-trapによる蚊の終夜採集を，4月より9月迄行った。1. 本年の平均気温が平年より上回ったのは6月に入ってからで，4月の降雨量は，平年より少なく，県南では，平年の50％以下であった。6月6日梅雨入りし，7月25日に明けた。8月に台風11号，9月に台風12号，16号が岡山附近を通った。本年の平均気温が，本格的に25℃を越えたのは，7月19日～8月28日の40日間で，昨年より20日間も短くなっている。2. アカイエカの採集総数が，昨年より増えたのは，岡山（保）で1.5倍，瀬戸で1.3倍，成羽で1.6倍，津山で3.4倍であった。一方倉敷，新見では，1/2に減少している。3. コガタイエカの採集総数が，昨年より増えたのは，笠岡で3.5倍，瀬戸で2.9倍，成羽で1.3倍，新見で5倍であった。一方減ったのは，倉敷で1/1.1，岡山（保）で1/1.6に減少している。4. シナハマダラカの採集総数が昨年より減ったのは，倉敷で1/2，瀬戸で1/1.5に，減少した。また岡山（保）では，雌3羽，雄3羽と少なく，西大寺保健所では，雌1羽だけで，岡大・医学部構内では，全然採集されなかった。5. 本年は新たに，岡山市西大寺保健所が定点に加えられ，一方岡大・医学部構内でも採集を行ったが，高い塀で囲まれている関係で，採集数も少なかった。6. 本年の採集蚊数で，アカイエカ，コガタイエカ，シナハマダラカ共に，昨年より増えたのは，笠岡，成羽，津山で共に昨年より減ったのは，倉敷のみであった。瀬戸では，アカイエカ，コガタイエカの増加がみられた。7. 本年は，日本脳炎患者の発生は，疑似患者のみで真性患者の発生は見られなかった。 en-copyright= kn-copyright= en-aut-name=InatomiSeiiti en-aut-sei=Inatomi en-aut-mei=Seiiti kn-aut-name=稲臣成一 kn-aut-sei=稲臣 kn-aut-mei=成一 aut-affil-num=1 ORCID= en-aut-name=ItanoKazuo en-aut-sei=Itano en-aut-mei=Kazuo kn-aut-name=板野一男 kn-aut-sei=板野 kn-aut-mei=一男 aut-affil-num=2 ORCID= en-aut-name=SuguriSetsuo en-aut-sei=Suguri en-aut-mei=Setsuo kn-aut-name=村主節雄 kn-aut-sei=村主 kn-aut-mei=節雄 aut-affil-num=3 ORCID= en-aut-name=TonguYasumasa en-aut-sei=Tongu en-aut-mei=Yasumasa kn-aut-name=頓宮廉正 kn-aut-sei=頓宮 kn-aut-mei=廉正 aut-affil-num=4 ORCID= en-aut-name=AjiToshiki en-aut-sei=Aji en-aut-mei=Toshiki kn-aut-name=安治敏樹 kn-aut-sei=安治 kn-aut-mei=敏樹 aut-affil-num=5 ORCID= en-aut-name=HaradaMasakazu en-aut-sei=Harada en-aut-mei=Masakazu kn-aut-name=原田正和 kn-aut-sei=原田 kn-aut-mei=正和 aut-affil-num=6 ORCID= en-aut-name=KaiJim-Shung en-aut-sei=Kai en-aut-mei=Jim-Shung kn-aut-name=頼俊雄 kn-aut-sei=頼 kn-aut-mei=俊雄 aut-affil-num=7 ORCID= en-aut-name=HoLi-Hsing en-aut-sei=Ho en-aut-mei=Li-Hsing kn-aut-name=何黎星 kn-aut-sei=何 kn-aut-mei=黎星 aut-affil-num=8 ORCID= en-aut-name=YamamotoTomoko en-aut-sei=Yamamoto en-aut-mei=Tomoko kn-aut-name=山本友子 kn-aut-sei=山本 kn-aut-mei=友子 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=3 en-affil= kn-affil=香川医科大学病理学講座寄生虫学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部寄生虫学教室 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=145 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Secondary prevention for myocardial infarction kn-title=心筋梗塞の二次予防戦略 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KohnoKunihisa en-aut-sei=Kohno en-aut-mei=Kunihisa kn-aut-name=河野晋久 kn-aut-sei=河野 kn-aut-mei=晋久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　整形外科 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=119 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The study of "physicians' explanations" in medical malpractice lawsuits kn-title=医療訴訟における「医師の説明」に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this study, a subset of medical malpractice lawsuits that are preventable was evaluated using qualitative data. The objective of this study is to help reduce the number of avoidable medical malpractice lawsuits. This qualitative study could pave the way to future quantitative studies. The analysis of the qualitative data revealed that in the vast majority of medical malpractice lawsuits filed by patients and their families there were ① an occurrence of unexpected bad outcomes, ② inadequate explanation by the patient's physician, and ③ involvement of an instigator who encouraged the lawsuit. That is, the failure of a physician to provide an adequate explanation to a patient or the inappropriate conduct of a physician after unexpected bad results, with or without an instigator's involvement, is the main reason patients file medical malpractice lawsuits. The physician providing an adequate explanation to patients after unexpected bad results (adequate post-event explanation) is the pivotal determinative factor in preventing avoidable medical malpractice lawsuits. en-copyright= kn-copyright= en-aut-name=FukumotoYoshiyuki en-aut-sei=Fukumoto en-aut-mei=Yoshiyuki kn-aut-name=福本良之 kn-aut-sei=福本 kn-aut-mei=良之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 en-keyword=医療訴訟 (medical malpractice lawsuits) kn-keyword=医療訴訟 (medical malpractice lawsuits) en-keyword=医師の説明 (physicians' explanation) kn-keyword=医師の説明 (physicians' explanation) en-keyword=インフォームド・コンセント (informed consent) kn-keyword=インフォームド・コンセント (informed consent) en-keyword=説明義務 (accountability) kn-keyword=説明義務 (accountability) en-keyword=関与者 (instigator) kn-keyword=関与者 (instigator) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=インプラント義歯ならびに可撤性部分床義歯を装着した多数歯欠損患者の残存歯の予後に関する10年間の後ろ向きコホート研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamazakiSeiya en-aut-sei=Yamazaki en-aut-mei=Seiya kn-aut-name=山崎聖也 kn-aut-sei=山崎 kn-aut-mei=聖也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=構造面接におけるワンメッセージクエスチョン：小児期及び思春期摂食障害患者の母親への心理的欲求の調査 kn-title=A One-Message Question in a Structured Interview: Investigating Psychological Needs of Children and Adolescents with Eating Disorders Directed toward Their Mothers en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name=渡邉久美 kn-aut-sei=渡邉 kn-aut-mei=久美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=内膜剥離術後またはステント留置術後の頚動脈における患者の画像データと超音波流速データを使用した流体力学的コンピュータシミュレーション kn-title=Computational Fluid Dynamics of Carotid Arteries after Carotid Endarterectomy or Carotid Artery Stenting Based on Postoperative Patient-Specific CT Angiography and Ultrasound Flow Data en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HayaseHitoshi en-aut-sei=Hayase en-aut-mei=Hitoshi kn-aut-name=早瀬仁志 kn-aut-sei=早瀬 kn-aut-mei=仁志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=3 article-no= start-page=106 end-page=111 dt-received= dt-revised= dt-accepted= dt-pub-year=1951 dt-pub=19510531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=健康人竝に正常ビリルビン血を呈する患者の尿中ビリルビン量に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=有地滋 kn-aut-sei=有地 kn-aut-mei=滋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學第一（山岡）内科教室 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=8 article-no= start-page=1708 end-page=1712 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=胸廓成形術の手術時出血量を対象とした肺結核患者の出血性素因に関する研究 第4編 胸廓成形術の手術時出血量と毛細血管抵抗との関聯に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=津下逸雄 kn-aut-sei=津下 kn-aut-mei=逸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=国立岩国病院 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=8 article-no= start-page=1704 end-page=1707 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=胸廓成形術の手術時出血量を対象とした肺結核患者の出血性素因に関する研究 第3編 胸廓成形術の手術時出血量と血液凝固機能との関聯に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=津下逸雄 kn-aut-sei=津下 kn-aut-mei=逸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=国立岩国病院 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=8 article-no= start-page=1701 end-page=1704 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=胸廓成形術の手術時出血量を対象とした肺結核患者の出血性素因に関する研究 第2編 胸廓成形術を実施せる肺結核患者の出血時間並びに血液凝固時間と手術時出血量との関聯に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=津下逸雄 kn-aut-sei=津下 kn-aut-mei=逸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=国立岩国病院 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=8 article-no= start-page=1693 end-page=1701 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=胸廓成形術の手術時出血量を対象とした肺結核患者の出血性素因に関する研究 第1編 胸廓成形術の血液諸性状に及ぼす影響と手術時出血量との関聯に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=津下逸雄 kn-aut-sei=津下 kn-aut-mei=逸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=国立岩国病院 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=8 article-no= start-page=1625 end-page=1631 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=眞正癲癇患者並に實験的癲癇家兎の腦髓に於けるアセチールコリン代謝に関する研究 第I編 真正癲癇患者の大脳皮質に於けるアセチールコリン代謝に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=沖修之 kn-aut-sei=沖 kn-aut-mei=修之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=1 article-no= start-page=107 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=肺切除の蛋白代謝について 第1編 肺切除患者の術前における蛋白代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西純雄 kn-aut-sei=西 kn-aut-mei=純雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=国立療養所山陽荘 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=1 article-no= start-page=75 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=鉤虫症に関する研究 第二編 鉤虫症患者の血液及び血漿「カタラーゼ」に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石合亨 kn-aut-sei=石合 kn-aut-mei=亨 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=10 article-no= start-page=1795 end-page=1796 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=子宮癌患者の核酸代謝 第2編 子宮癌患者尿中Uracil, Thymin劃分の濾紙クロマトグラフ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=花岡恒夫 kn-aut-sei=花岡 kn-aut-mei=恒夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部生化学教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=10 article-no= start-page=1789 end-page=1794 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=子宮癌患者の核酸代謝 第1編 子宮癌患者尿中Uracil量の測定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=花岡恒夫 kn-aut-sei=花岡 kn-aut-mei=恒夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部生化学教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=10 article-no= start-page=1783 end-page=1784 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19531031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=日本腦炎患者の髓液中酪酸値に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤森明良 kn-aut-sei=藤森 kn-aut-mei=明良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=6 article-no= start-page=783 end-page=788 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=柵原鑛山に於ける珪肺症の研究 第I報 珪肺症患者の血液像並びに臨床像 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=淵本昭 kn-aut-sei=淵本 kn-aut-mei=昭 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤井幸雄 kn-aut-sei=藤井 kn-aut-mei=幸雄 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=白髪克也 kn-aut-sei=白髪 kn-aut-mei=克也 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=水田勝 kn-aut-sei=水田 kn-aut-mei=勝 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部 affil-num=2 en-affil= kn-affil=岡山大学医学部 affil-num=3 en-affil= kn-affil=岡山大学医学部 affil-num=4 en-affil= kn-affil=岡山大学医学部 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=5 article-no= start-page=599 end-page=602 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=胃癌患者に於ける無機物質特にK代謝に就て 第2編 胃癌患者の血清，筋肉，肝臟内のK量に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=村川浩正 kn-aut-sei=村川 kn-aut-mei=浩正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=2 article-no= start-page=245 end-page=257 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=胃癌患者に於ける蛋白代謝に關する研究 第2編 胃癌患者のアミノ酸代謝に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐藤亀弘 kn-aut-sei=佐藤 kn-aut-mei=亀弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=2 article-no= start-page=229 end-page=244 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=胃癌患者に於ける蛋白代謝に關する研究 第1編 胃癌患者の窒素代謝及び胃切除術による影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐藤亀弘 kn-aut-sei=佐藤 kn-aut-mei=亀弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=2 article-no= start-page=225 end-page=228 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=第三編 癌患者の血清，尿，胃液の抗原性に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=磯田義明 kn-aut-sei=磯田 kn-aut-mei=義明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=1 article-no= start-page=79 end-page=85 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ストレプトマイシン治療を受けた患者の結核性腸潰瘍に於ける光輝細胞の増殖 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=谷弘光 kn-aut-sei=谷 kn-aut-mei=弘光 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2491 end-page=2499 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=STUDIES ON THE TYROSINE LEVELS OF NON-HEAT PRECIPITATED, PROTEIN-LIKE MATERIALS OF HUMAN SERUM AND GASTRIC JUICE IN CANCER PATIENTS Chapter II Studies on the Tyrosine Levels of Non-heat Precipitated Protein-like Materials of Human Gastric Juice in Gastric Cancer Patients kn-title=胃癌患者の胃液に含まれる対熱非凝固物質各分屑中のチロジン量について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The protein-like materials of gastric juice consists of many kinds of non-heat precipitated mucous materials. By means of the quantitative analysis of the tyrosine levels contained in these materials and the isolated tyrosine level of gastric juice, the resolution of protein in cancer patients has been examined. In the case of the quantitative analysis of the tyrosine in total dissolved mucin and isolated tyrosine using trichlor acetic acid filtrate of gastric juice which was gathered after the subcutaneous injection of histamin, the tyrosine levels in total dissolved mucin in the cases of gastric cancer, gastric ulcer and gastritis were almost all the same. The isolated tyrosine levels in the cases of ulcer and gastritis, however, were 2-11 mg%, while that in the case of the gastric cancer was 9-26 mg%. It means the increase of isolated amino acid in gastric juice of cancer patients. According to Glass, Boyd and so forth, dissolved mucin was classified into mucoprotein and mucoproteose, and quantified the tyrosine levels of each of them. In the case of gastric cancer the tyrosine level of mucoprotein evidently decreased, but that of mucoproteose increased rather than that in the case of ulcer and gastritis. On the other hand the secretory volme of gastric juice showed clear decrease in patients with cancer. Consequently the tyrosine level of secretory mucoprotein (the tyrosine level of mucoprotein mg% × the secretory volume cc.) markedly decreased in the case of gastric cancer in comparison with the cases of ulcer and gastritis: that is, in the cases of gastric cancer the average level was 19 mg. in half an hour and 5 mg in 30 to 60 minutes after histamin injection, while in the cases of ulcer and gastritis the average levels were 201 mg and 107 mg respectively. The tyrosine levels of secretory mucoproteose did not show so clear distinction as that of mucoprotein Then fifteen cases of gastric cancer were classified into the following four groups. hydrochloric acid the tyrosine level of mucoprotein Group I (1 case) (+) normal Group II (3 cases) (-) normal Group III (7 cases) (-) decrease Group IV (4 cases) (-) little and impossible to quantitative analysis Comparing with clinical appearance, the anemia level was the highest in the group IV, which was followed by the group III, that of the group II was the lowest, and no anemia was noticed in the group I. In the view-points of the growth of cancer and indication of gastric resection, radical operations were possible in all the cases of group I, II and in the 4 cases of group III. On the other hand only the exploratory laparotomy was performed in the remaining 3 cases of group III and all the cases of group IV. According to Glass, Boyd, Rubinstein and so forth, mucoprotein is secreted from so-called “mucoid cells” in the neck of gastric gland, and it is similar to Castle's intrinsic factor from the physical and physiological points of view. We often become aware in daily clinical experiences that the degree of anemia is often higher in the case of cancer of stomack than the other viscera such as breast, lung, esophagus, colon, rectum, and so forth. Therefore the deficiency of gastric mucoprotein may be related to the anemia level in gastric cancer patients. en-copyright= kn-copyright= en-aut-name=TaninoJyunzo en-aut-sei=Tanino en-aut-mei=Jyunzo kn-aut-name=谷野順造 kn-aut-sei=谷野 kn-aut-mei=順造 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2485 end-page=2489 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=STUDIES ON THE TYROSINE LEVELS OF NON-HEAT PRECIPITATED, PROTEIN-LIKE MATERIALS OF HUMAN SERUM AND GASTRIC JUICE IN CANCER PATIENTS Chapter I Studies on the Tyrosine Levels of Non-heat Precipitated, Protein-like Materials of Human Serum kn-title=癌患者の血清対熱非凝固物質中チロジン量について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Human serum contains resolved materials of protein and these resolution shows one section of protein metabolism. It is observed that the consumption of protein is clear in patients with cancer, and the quantity of non-heat precipitated protein-like materials increases in certain periods during the course of this disease. The examination of the resolving condition of protein was performed by means of the quantitative analysis of the tyrosine content in non-heat precipitated protein-like materials using the phenol reagent. In comparison with 3.2 mg% (2-5 mg%) which was the average tyrosine level of healthy human serum (10 cases), that of cancer of the lung (3 cases) was 11.2 mg% (8-17 mg%); of the stomach (42 cases) was 8.4 mg% (3-13 mg%); of the breast (8 cases) was 5.8 mg% (2-8 mg); of the rectum (5 cases) was 4.9 mg% (2-8 mg%); and of the sarcoma (5 cases) was 11.8 mg% (8-16 mg%). The tyrosine level of ulcer of the stomach and duodenum (35 cases) was 4.7 mg% (2-8 mg%), and this is lower than the level of cancer of the stomach. The tyrosine level of penetrating ulcer (5 cases), however, was 9.3 mg% (8-12 mg%) and it is higher than that of cancer of the stomach. In such diseases the resolution of protein is supposed to be evident, and this fact suggests hypoproteinemia and shows the necessity of supplying protein prior to operation in order to be favourable prognosis. Futhermore, the fact that the tyrosine level in the terminal stadium of cancer of the stomach with cancerous peritonitis becomes the same with that in healthy condition suggests us to be cautious in making diagnosis in the case of hypoproteinemia and cancer. Moreover, in the case of inflammatory and wasting disease except cancer. for instance, abscess of the lung, tuberculosis of the intestine, that of the kidney, and peripleural abscess, the tyrosine level becomes higher than 7-10 mg%. en-copyright= kn-copyright= en-aut-name=TaninoJyunzo en-aut-sei=Tanino en-aut-mei=Jyunzo kn-aut-name=谷野順造 kn-aut-sei=谷野 kn-aut-mei=順造 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2379 end-page=2384 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the far Examination Result about Patients of Infectious Hepatitis 1st Report. Ist Examination Result in Akaiwa Area kn-title=流行性肝炎患者の遠隔成績について 第1報 赤磐地区に於ける第一回検診成績 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Re-examining 153 cases of infectious hepatitis patients in Akaiwa area, Okayama Prefecture, the result was that some cases seemed to have distinctly shifted to chronic hepatitis, along with cases of latent hepatitis without conscious symptoms, to the extent of about 1/8 of total cases; moreover, there were pretty many who should be taken care of: where, there were few cases of perfect recovery. Besides, 2 cases were recognized which shifted tohepatic cirrhosis, one of which could be given testimony owing to autopsy. The chronic turn like this was of course seen in serious cases, but even in slightly-affected cases, if thorough treatment was out of use (esp., quiet repose); so that, in its treatment, utmost care should be taken; besides, as to the decision of recovery, one should take resort to every means to ensure it. en-copyright= kn-copyright= en-aut-name=KosakaKiyowo en-aut-sei=Kosaka en-aut-mei=Kiyowo kn-aut-name=小坂淳夫 kn-aut-sei=小坂 kn-aut-mei=淳夫 aut-affil-num=1 ORCID= en-aut-name=SetoKeitaro en-aut-sei=Seto en-aut-mei=Keitaro kn-aut-name=瀬戸桂太郎 kn-aut-sei=瀬戸 kn-aut-mei=桂太郎 aut-affil-num=2 ORCID= en-aut-name=MorimotoKaichi en-aut-sei=Morimoto en-aut-mei=Kaichi kn-aut-name=森本嘉一 kn-aut-sei=森本 kn-aut-mei=嘉一 aut-affil-num=3 ORCID= en-aut-name=OginoShigemi en-aut-sei=Ogino en-aut-mei=Shigemi kn-aut-name=荻野重美 kn-aut-sei=荻野 kn-aut-mei=重美 aut-affil-num=4 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=5 ORCID= en-aut-name=ShimadaNobuhiro en-aut-sei=Shimada en-aut-mei=Nobuhiro kn-aut-name=島田宜浩 kn-aut-sei=島田 kn-aut-mei=宜浩 aut-affil-num=6 ORCID= en-aut-name=IoriyaTsuneo en-aut-sei=Ioriya en-aut-mei=Tsuneo kn-aut-name=庵谷恒夫 kn-aut-sei=庵谷 kn-aut-mei=恒夫 aut-affil-num=7 ORCID= en-aut-name=IwaharaMasao en-aut-sei=Iwahara en-aut-mei=Masao kn-aut-name=岩原正雄 kn-aut-sei=岩原 kn-aut-mei=正雄 aut-affil-num=8 ORCID= en-aut-name=AmakoTakashi en-aut-sei=Amako en-aut-mei=Takashi kn-aut-name=尼子隆士 kn-aut-sei=尼子 kn-aut-mei=隆士 aut-affil-num=9 ORCID= en-aut-name=HinoMasuo en-aut-sei=Hino en-aut-mei=Masuo kn-aut-name=日野益雄 kn-aut-sei=日野 kn-aut-mei=益雄 aut-affil-num=10 ORCID= en-aut-name=KawaguchiMasamitsu en-aut-sei=Kawaguchi en-aut-mei=Masamitsu kn-aut-name=川口正光 kn-aut-sei=川口 kn-aut-mei=正光 aut-affil-num=11 ORCID= en-aut-name=IshidaTatsuo en-aut-sei=Ishida en-aut-mei=Tatsuo kn-aut-name=石田立夫 kn-aut-sei=石田 kn-aut-mei=立夫 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=12 en-affil= kn-affil=岡山県衛生部公衆衛生課 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=11 article-no= start-page=2217 end-page=2228 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=1. Studies on extracellular fluid in cancer patients kn-title=癌患者の細胞外液相量に関する研究 第1編 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The recent studies on the extracellular fluid in cancer patients have demonstrated a reduced blood volume and an increased interstitial fluid volume. By measurements of the extracellular fluid in patients with gastric cancer and gastric ulcer. I could compare them with the fluid in healthy persons and the following results were obtained: 1. On the extracellular fluid, each of cancer and ulcer patients has an increased volume more than that of healthy persons and the remarkable increase was observed in especially the former and the patients in such poor condition that lost the body weight as much as 12kg. or more than that, but the influence of passage disturbance of the pylorus was not recognized npon the extracellular fluid of gastric cancer. 2. The circulatory plasma volume was also recognized its increase more than the volume of healthy adults. The parallel relation between the plasma volume and the extracellular fluid was not confirmed on the whole except a few cases. 3. On the circulatory blood volume, there was no special difference among them. 4. The cell mass was reduced more in cancer and ulcer patients either than in healthy persons and in cancer patients the reduction was remarkable. 5. The alteration on the extracellular fluid which caused by blood transfusion was very little in a short term. The character of extracellular fluid is very complicated and is very difficult to explain about it, but I can assume that the remarkable increase in cancer patients is caused by the spread of the thiocyanate space. en-copyright= kn-copyright= en-aut-name=NakamuraTetsuro en-aut-sei=Nakamura en-aut-mei=Tetsuro kn-aut-name=中邑哲郎 kn-aut-sei=中邑 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=819 end-page=823 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=鉤虫症に関する研究 第一編 鉤虫症患者の糞便に就て種々精査 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=柴田雅男 kn-aut-sei=柴田 kn-aut-mei=雅男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=1227 end-page=1248 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Plasma Proteins of Patients with Gastric Cancer and the Effect of Operation them III. Circulating Blood Volume, Circulating Plasma Volume, Circulating Cell Volume, Total Circulating Plasma Protein Mass and Total Circulating Hemoglobin Mass in Patients with Gastric Cancer kn-title=胃癌患者の血漿蛋白並びに之に及ぼす手術の影響について 第III編 胃癌患者の循環血液量，同血漿量，同血球量，循環血漿蛋白量，同ヘモグロビン量並びに之に及ぼす手術の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The data presented in the second paper indicated that in Patients with gastric cancer the preoperative determinations of albumin content and albuminglobulin ratio were of value for judging the patient's condition of nutrition and operative prognosis, but that the alternation occurring in the concentrations of plasma protein fractions following operation was not always proportional to the preoperative degree of protein deficiency and the clinical picture. Therefore this paper is concerned with the study on hypoproteinemia in patients with gastric cancer on the base of the examination of both the concentration and the total circulating mass of plasma protein. Blood volume, plasma volume, cell volume, total circulating plasma protein mass, total circulating hemoglobin mass, plasma protein contration and hemoglobin concentration in 14 patients with gastric cancer were measured before and after operation. As control material similar studies were made in 11 normal persons, in 13 patients with gastroduodenal ulcer, in 5 cases of cancer of the brest and in 4 cases of Graves' disease. Additional studies were done to determine a standard of blood requirement to be transfused by investigating the effect of transion in the cases in which blnod had been administered before and after operation. The resnlts of these studies were as follows: 1. In patients with gastric cancer there was a decrease in blood volume and in cell volume. 2. Plasma volume was above normal in many patients with gastric cancer and decreased in only a few cases. 3. The decreased blood volume in patients with gastric cancer chiefly was due to a reduction of cell volume, and there were a few cases where plasma volume was concerned in it. 4. The prognosis of the patients with gastric cancer who had a decreased blood volume was poor. 5. In patients with gastric cancer a decrease of both total circulating hemoglobin mass was noted, the loss of the later being more pronounced. 6. In patients with gastric cancer the transfusion of at least 1000 cc each of whole blood and plasma was considered necessary before operation. 7. In patients with gastric cancer blood volume, plasma volune and cell volume were reduced 4 to 8 days after the resection of the stomach. After the 12th postoperative day, plasma volume increased, whereas cell volume did little. 8. Total circulating plasma protein mass in patients with gastric cancer decreased 4 to 8 days after operation, but increased after the 12th postoperative day. 9. Total circulating hemoglobin mass in patientients with gastric cancer.was markedly decreased following resection of the stomach. The value showed a especially sharp decrease on the 4th postoperative day and still further decreased gradually afterwards and there were a few cases in which it shifted to the increase on discharge from the hospital. 10. There were the cases of gastric cancer where a discrepancy between the concentration and the total circulating mass of blasma protein was noted and this tendency was more striking in both of hemoglobin. It was often difficult, therefore, to estimate total circulating mass of plasma protein and hemoglobin by the determination of only concentration of plasma protein and hemoglobin. 11. Total plasma protein mass rather than total total hemoglbin mass was suitable as an index of tissue protein deficiency in the postoperative course of patients with gastric cancer. 12. The variations in values of blood determined after operation in patiens with gastric cancer depended on the preoperative state of body nutrition and on the amount of blood postoperatively transfused. In well nourished patients and in those transfused over 800cc of blood, the degree of reduction in blood volume aud plasma volume was low, and on discharge from the hospital, there was a tendency for total circulating plasma protein mass to increase above the preoperative value. en-copyright= kn-copyright= en-aut-name=ShiotaBenjiro en-aut-sei=Shiota en-aut-mei=Benjiro kn-aut-name=塩田弁治郎 kn-aut-sei=塩田 kn-aut-mei=弁治郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=1209 end-page=1226 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Plasma Proteins of Patients with Gastric Cancer and the Effect of Operation them II. Plasma Protein Fractions in Patients with Gastric Cancer and the Efiect of Operatlon on them kn-title=胃癌患者の血漿蛋白並びに之に及ぼす手術の影響について 第II編 胃癌患者の血漿蛋白分劃並びに之に及ぼす手術の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The data presented in the first paper demonstrated that patients with gastric cancer suffered from a significant decrease in plasma proteins concentration on admission to the hospital, but that the postoperative course was frequently associated with a increased plasma protein content. It is the purpose of this paper to discuss these findings by the determination of plasma protein fractions. The pre- and post-operative concentrations of plasma protein protein fractions in 47 patients with gastric cancer were measured by refractometry and electrophoresis. As control material 15 normal individuals including mild patients near normal, 13 cases of rectal cancer, 13 cases of various types of cancer other than that of the alimentary tract, 9 cases of sarcoma and 29 patients with gastroduodenal ulcer-a total of 90 cases-were selected. The following results were obtained: 1. Patients with gastric cancer showed a marked decrease of albumin fraction. This is the cause of the hypoproteinemia in these patients. 2. The decreased albumin concentration in patients with gastric cancr was noted to become more profound with the progress of the disease. 3. The reduction of albumin content in patients with gastric cancer was more pronounced in the cases where the passageway of the stomach was not patent than in those where it was patent. 4. In patients with gastric cancer an increase of both globulin and fibrinogen fraction was demonstrated. 5. With the occurrence of metastasis of gastric cancer in the liver, there was found an increase in β- and γ-globulins. 6. Albumin-globulin ratio in patients with gastric cancer was lowered and became lower with the progress of the disease. 7. The albumin level and the albumin-globulin ratio in patients with gastric cancer proved to be the index of the prognosis, and albumin levels below 2.70g/dl and albumin-globnlin ratio under 1.0 were associated with an increased incidence of the cases where radical operation was not indicated and of postoperative complications. 8. The determination of plasma protein fractions was of little significance in the differential diagnosis between gastric cancer and gastroduodenal ulcer. 9. The albumin concentrations in patients with gastric cancer decreased after gastric resection. The degree of the decrease was more profound in the cases where preoperative levels of albumin were higher. On discharge from the hospital the albumin contents were, in most cases, found to increase over those before operation. 10. An increase in both fibrinogen and globulin fractions occurred after gastric resection for cancer. On discharge from the hospital these levels, although lowered, yet remained slightly higher than those before operation. en-copyright= kn-copyright= en-aut-name=ShiotaBenjiro en-aut-sei=Shiota en-aut-mei=Benjiro kn-aut-name=塩田弁治郎 kn-aut-sei=塩田 kn-aut-mei=弁治郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=1195 end-page=1207 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Plasma Proteins of Patients with Gastric Cancer and the Effect of Operation them I. Plasma Protein Concentrations in Patients with Gastric Cancer and the Effect of Operation on them kn-title=胃癌患者の血漿蛋白並びに之に及ぼす手術の影響について 第1編 胃癌患者の血漿蛋白並びに之に及ぼす手術の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Patients with gastric cancer today coming under the care of surgeon often considerably malnourished. Because of a high incidence of postoperative complications and deaths in these patients, a study was instituted to investigate the state of their plasma proteins. This paper deals with the plasma protein concentrations in patients with gastic cancer, the effect of operation on them and the significance of plasma protein determination in therapy and as a prognostic aid. The concentrations of plasma protein in 43 patients with gastric cancer were pre- and post-operatively measured by copper sulfate specific gravity method, and 10 normal persons and 26 patients with gastroduodenal ulcer were studied as the control. The results obtained were as follows: 1. A significant decrease in the preoperative concentrations of plasma protein was observed in patients with gastric cancer. 2. Whether radical operation could be performed or not, and whether the gastric passageway was patent or not, made no difference in the plasma protein levels of patients with gastric cancer. 3. The determination of plasma protein was of little significance in the differential diagnosis between gastric cancer and gastroduodenal ulcer except in special cases. In the absence of massive hemorrhage or severe obstruction, plasma protein concentrations below 6.5 g/dl had some significance, those below 6.0 g/dl having a important significance. 4. The lowest level of plasma protein concentration in the patients who overcame a partial gastrectomy for gastric cancer was 4.72 g/dl. 5. Following resection of the stomach for gastric cancer, it was in most cases found that a decrease in plasma protein concentration occurred in the patients having the preoperative level abov 6.5 g/dl, whereas an increase occurred in those showing a level lower than 6.5 g/dl before operation. 6. The most pronounced drop in plasma protein concentration occurred about 7 to 12 days after gastric resection for cancer of the stomach. 7. Most of the patients with gastric cancer who underwent merely exploratory laparotomy or gastrojejunostomy because radical operation was impossible to be performed, showed a increased concentration of plasma protein after operation. 8. Death following operation for gastric cancer was found to occur in the patients who had low levels of plasma protein concentration. en-copyright= kn-copyright= en-aut-name=ShiotaBenjiro en-aut-sei=Shiota en-aut-mei=Benjiro kn-aut-name=塩田弁治郎 kn-aut-sei=塩田 kn-aut-mei=弁治郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=12 article-no= start-page=3199 end-page=3206 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19571231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinical study of the general anesthesia for the patients with anemia and hypoproteinemia Part 2. The interrelationships between the induction time of cyclopropane anesthesia and the blood components in anemic and hypoproteinemic patients kn-title=貧血ならびに低蛋白血症患者の全身麻酔に関する臨床的研究 第2編 貧血および低蛋白血症患者全身麻酔時における麻酔導入時間と血液諸成分との関係について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty-two patients with anemia and hypoproteinemia were anesthetized with cyclopropane and the interrelationships between the induction time of anesthesia and the peripheral blood corpuscles or plasma protein were investigated. 1) A reverse interrelationship was seen between the induction time of cyclopropane anesthesia and the water content of the plasma. 2) A parallel interrelationship was seen between the induction time of cyclopropane anesthesia and the total plasma protein. 3) The interrelationships were not found between the induction time of cyclopropane anesthesia and hemoglobin, the erythrocytes, the increased rate of the leucocytes, hemoglobin concentration, hematcrit, the water content of blood and each fraction of the plasmaprotein. 4) In the patients with hypoproteinemia, the stage of anesthesia easily tends to be deeper. Therefore, coutious attention should be called. 5) On the contrary, in the patients with anemia there were not the tendency to be deeper. I imagine cyclopropane is well available for the patients with anemia. en-copyright= kn-copyright= en-aut-name=KunitomoKeiichi en-aut-sei=Kunitomo en-aut-mei=Keiichi kn-aut-name=国友桂一 kn-aut-sei=国友 kn-aut-mei=桂一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=12 article-no= start-page=3181 end-page=3198 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19571231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinical study of the general anesthesia for the patients with anemia and hypoproteinemia Part 1. The changes of the blood components before and after cyclopropane anesthesia in anemic and hypoproteinemic patients kn-title=貧血ならびに低蛋白血症患者の全身麻酔に関する臨床的研究 第1編 貧血および低蛋白血症患者の全身麻酔前後における血液諸成分の変動について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Thirty-three patients with anemia and hypoproteinemia were anesthetized with cyclopropane and the changes in the peripheral blood corpuscles and the plasma protein were observed before and after anesthesia. 1) The number of the erythrocytes slightly increased already 20 minutes after starting anesthesia, while the leucocytes markedly increased. In the increase of the leucocytes, An increase of the neutrophils and an marked increase of the lymphocyte were observed. Hemoglobin as well as hematcrit increased, while the water content of blood and plasma decreased. 2) Total plasma protein increased and its fractioning revealed an increase of A/G ratio, slight increase of albumin, decrease of α-globulin as well as φ, slight increase of γ-grobulin and no change of β-globulin in percentage. From the quantitative point, there were observed an increase of Al. slight increase of β-Gl., decrease of φ, increase of γ-Gl. and no change of α-Gl.. 3) These changes in the peripheral blood corpuscles and the plasma protein are considered to be due to the temporary increase of adrenalin secretion caused by cyclopropane as stressor, though there may be some exemia (concentration of the blood) due to general anesthesia. en-copyright= kn-copyright= en-aut-name=KunitomoKeiichi en-aut-sei=Kunitomo en-aut-mei=Keiichi kn-aut-name=国友桂一 kn-aut-sei=国友 kn-aut-mei=桂一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=12 article-no= start-page=3037 end-page=3052 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19571231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental studies on the metabolism of erythrocytes of acatalasemia patients Report 2 The influences of various substances on the oxygen consumption of erythrocytes both in acatalasemia patients and the normal kn-title=無カタラーゼ血液症患者の赤血球代謝に関する実験的研究 第2編 無カタラーゼ血液症患者及び健康人の赤血球酸素消費に及ぼす数種物質の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By examining the influences of protoporphyrin and of four kinds of metal ions, namely, those of iron, zinc, magnesium, and manganese, and the influences of glucose, lactate, glycerophosphate, acetate, pyruvate, glutamate, succinate, fumarate, malate, and aspartate, methylene blue and DPN, on the oxygen consumption of erythrocytes both in acatalasemia patients and the normal, and by further spectroscopic studies on the changes of the hemoglobin accompanying the respiration of erythrocytes when malate and aspartate of these had been used as substrates, the author reached the following conclusions: namely, in the respiration of erythrocytes of these patients as compared with the normal, no marked difference other than a comparatively weaker enzymatic action of malic dehydrogenase and the enzymes concerning aspartic acid oxidation can be recognized; and as for the disposal of small amounts of H(2)O(2) supposedly to be liberated during respiration of erythrocytes, the compensation by peroxidase, hemoglobin, or other hemin proteins may be thought to be sufficient. en-copyright= kn-copyright= en-aut-name=YoshidaKiyoaki en-aut-sei=Yoshida en-aut-mei=Kiyoaki kn-aut-name=吉田清明 kn-aut-sei=吉田 kn-aut-mei=清明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=12 article-no= start-page=3031 end-page=3036 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19571231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental studies on the metabolism of erythrocytes of acatalasemia patients Report 1 The fluctuation of the pyruvic acid contents accompanying the respiration of erythrocytes both in acatalasemia patients and the normal kn-title=無カタラーゼ血液症患者の赤血球代謝に関する実験的研究 第1編 無カタラーゼ血液症患者及び健康人の赤血球呼吸に伴う焦性ブドウ酸量の消長 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By adding various substrates such as glucose, lactate, pyruvate, aspartate, malate, and alanine to both acatalasemia patients and the normal, the fluctuation of the pyruvic acid contents accompanying the respiration of erythrocytes had been investigated, but no difference of the contents could be observed between the two groups. Thus it has now become clear that even in these patients the pyruvic acid in erythrocytes, in so far as the respiration of erythrocytes, takes hardly any acitve part in the disposal of H(2)O(2)supposedly to be liberated during respiration. en-copyright= kn-copyright= en-aut-name=YoshidaKiyoaki en-aut-sei=Yoshida en-aut-mei=Kiyoaki kn-aut-name=吉田清明 kn-aut-sei=吉田 kn-aut-mei=清明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=431 end-page=446 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Epidemiologic and Symptomatologic Observations on the Gastric Cancer Patients (Hospitalized Patients, 1945-1956 and Outpatients, 1954-1955) kn-title=胃癌患者の疫学的並びに症候的観察―昭和20～31年の入院患者並びに昭和29, 30年の外来患者について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Conceding that a great progress of cancer researches is opening up a new phase in the treatment of cancers and realizing an early operation is at the present a sole approach to the gastric-cancer therapy, an early diagnosis seems to be the most important, daily clinical problem we have to face. In view of this we have attempted to grasp the true nature of gastric-cancer patients by a series of epidemiologic and symptomatologic observations statistically on the hospitalized patients during the past 12 years, and outpatients for the past 2 years of our clinic. From our observations we find that the most likely ages of the onset of cancers range from 50 to 60, and that the gastric cancer developing at an early age is found more predominantlyin female. Moreover, in the farm districts, the proportion of female patients far surpasses that of any other occupation. Of all the cancer cases treated during the 12-year periods, the gastric cancer occupied 45 per cent. Of all the outpatients during the two-year periods, 27.8 per cent proved to be suffering from digestive organs; and the gastric cancer cases occupied 5.7 per cent of the latter. Now, it is impossible, simply by its symptoms, to differentiate the gastric cancer from such diseases as the gastric and the duodenal ulcers, and gastritis; as the symptom and chief complaint of the patients at its onset are epigastric pain, the foremost, followed by feeling of full and tension in the epigastrium, and eructation and heart burn, and since all of these have practically no distinguishable difference from those of the latter. Of the total patients, the cases impossible of operation reached as high as 39 per cent while those being operated on but ending only in laparotomy proved to be 15 per cent, and the ones on whom the gastric resection had proved a success were merely 8.8 per cent. It is, moreover, interesting to note that despite as high as 75.8 per cent of the cases having palpable abdominal tumors at the time of admission, the ones whose Virchow's gland and other lymphatic glands had been palpable were extremely little: no more than 0.6 per cent. The occult blood reaction of stool was positive in 71 per cent, and 18 per cent of gastric cancer patients were of either normal or hyper acidity; and 61 per cent of the total had abnormal defecation (constipation, diarrhea, etc.). As for complications, helminthiasis is predominant (30%). This fact is worthy of an attention, for symptoms resulting from helminth's attacks often obscure those of gastric cancer. Reviewing the statistical data so far mentioned, we realize keenly how little early diagnosis of gastric cancer is being carried out and how difficult it is to carry this out; at the same time we have learned, on the other hand, how essential and beneficial it is to grasp epidemiologic and symptomatologic problems for its diagnosis. en-copyright= kn-copyright= en-aut-name=UeharaHideo en-aut-sei=Uehara en-aut-mei=Hideo kn-aut-name=上原偉男 kn-aut-sei=上原 kn-aut-mei=偉男 aut-affil-num=1 ORCID= en-aut-name=OkuhashiAtsumu en-aut-sei=Okuhashi en-aut-mei=Atsumu kn-aut-name=奥橋褒 kn-aut-sei=奥橋 kn-aut-mei=褒 aut-affil-num=2 ORCID= en-aut-name=MoritaniHideo en-aut-sei=Moritani en-aut-mei=Hideo kn-aut-name=森谷秀男 kn-aut-sei=森谷 kn-aut-mei=秀男 aut-affil-num=3 ORCID= en-aut-name=HattoriSusumu en-aut-sei=Hattori en-aut-mei=Susumu kn-aut-name=服部進 kn-aut-sei=服部 kn-aut-mei=進 aut-affil-num=4 ORCID= en-aut-name=UetsukaKaoru en-aut-sei=Uetsuka en-aut-mei=Kaoru kn-aut-name=上塚香 kn-aut-sei=上塚 kn-aut-mei=香 aut-affil-num=5 ORCID= en-aut-name=SanadaHiroshi en-aut-sei=Sanada en-aut-mei=Hiroshi kn-aut-name=真田浩 kn-aut-sei=真田 kn-aut-mei=浩 aut-affil-num=6 ORCID= en-aut-name=MotokuraKiyoshi en-aut-sei=Motokura en-aut-mei=Kiyoshi kn-aut-name=本倉潔 kn-aut-sei=本倉 kn-aut-mei=潔 aut-affil-num=7 ORCID= en-aut-name=HayashiKazuo en-aut-sei=Hayashi en-aut-mei=Kazuo kn-aut-name=林和雄 kn-aut-sei=林 kn-aut-mei=和雄 aut-affil-num=8 ORCID= en-aut-name=MiyaiMonziro en-aut-sei=Miyai en-aut-mei=Monziro kn-aut-name=宮井絞治郎 kn-aut-sei=宮井 kn-aut-mei=絞治郎 aut-affil-num=9 ORCID= en-aut-name=NishiuchiMichio en-aut-sei=Nishiuchi en-aut-mei=Michio kn-aut-name=西内道雄 kn-aut-sei=西内 kn-aut-mei=道雄 aut-affil-num=10 ORCID= en-aut-name=MatsuyamaTsuneo en-aut-sei=Matsuyama en-aut-mei=Tsuneo kn-aut-name=松山恒男 kn-aut-sei=松山 kn-aut-mei=恒男 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=387 end-page=393 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistical Observations on the so-called Cachexia in Patients of Cancer of the Uterine Cervix (Survey in Okayama University Hospital) kn-title=子宮頸癌患者の所謂悪液質に関する統計的観察 （岡大婦人科における最近21年間の統計） en-subtitle= kn-subtitle= en-abstract= kn-abstract=The authors studied patients of cancer of the uterine cervix treated by radiation duriug 1934 to 1954, in the Gynecoloèical Department of Okayama Univ. Med. Sch., with especial reference to the so-called “cachexia” in carcinoma. The so-called cachexia were 96 cases (4.8%) out of 1, 974 cases in all, and many of them were in their fifties. There were no relation to the delivery, cancer disposition nor to tuberculous history. The so-called cachexia increased in number with progress of cancer, and 81% of them were seen in Stages III & IV. Although, the primary location of cancer had no relation to its frequency, there were many cases with cancerous infiltration in the vaginal wall and 6 cases which were complicated with metastatic Virchow's glands. Most of the cases showed haemograms for example, R. B. C.: less than 2 millions, W. B. C.: more than 9, 000, Haemoglobin: less than 60% Sahli, Sediment test: more than 80 mm an hour. During the radiological treatment they were frequently complicated with primary death during hospitalisation, parametritis, severe hemorrhage, thrombosis and vaginal fistula. Blood tranfusion to such cachectic patients revealed that no serious by-effects were observed, but a febrile reaction was 38.0%. As to the fate of the cachectics it was noted that primary death 15.7%, death cases within 1 year was about 2/3 and that the 5 year survival was 11.4%. en-copyright= kn-copyright= en-aut-name=SarataniK. en-aut-sei=Saratani en-aut-mei=K. kn-aut-name=更谷一夫 kn-aut-sei=更谷 kn-aut-mei=一夫 aut-affil-num=1 ORCID= en-aut-name=HiraiS. en-aut-sei=Hirai en-aut-mei=S. kn-aut-name=平井栄 kn-aut-sei=平井 kn-aut-mei=栄 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産婦人科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部産婦人科教室 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IgA腎症患者の扁桃Bリンパ球における糖転移酵素遺伝子の特異的発現が蛋白尿および腎機能障害と関連する kn-title=Differential expression of glycogenes in tonsillar B lymphocytes in association with proteinuria and renal dysfunction in IgA nephropathy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=InoueTatsuyuki en-aut-sei=Inoue en-aut-mei=Tatsuyuki kn-aut-name=井上達之 kn-aut-sei=井上 kn-aut-mei=達之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=12-2 article-no= start-page=8363 end-page=8373 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bronchospirometry with Carlens' Double Lumen Catheter Part 1. Bronchospirometry in Different Positions: Study on Patients with Pulmonary Tuberculosis kn-title=Carlens気管支カテーテルによる左右別気管支肺容量測定に関する研究 第1編 肺結核患者の各体位における呼吸機能について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bronchospirometries in the supine and both lateral positions have been performed on 20 patients with pulmonary tuberculosis. Ten of them had also determination made while sitting. Following results were obtained. 1) The total oxygen consumption showed a slight increase in both right and left lateral positions as compared with while supine. A definite increase both in the absolute amount and in the percentage of oxygen consumption was noted in the under lung in the lateral position. 2) A slight increase in absolute amount and a definite increase in the percentage of minute volume and tidal volume were noted in the under lung. 3) The ventilation equivalent decreased in the under lung, indicating increased efficiency. 4) Both total and differential vital capacity showed no change in both lateral positions. However, a definite decrease both in the absolute amount and in the percentage of reserve air was noted in the under lung in the lateral position. 5) In the sitting position pulmonary function improved in every respects. This position was considered less resistant for respiration than the other positions. These findings were entirely similar as found in the study of the same kind made on normal persons. en-copyright= kn-copyright= en-aut-name=KishimotoSeibi en-aut-sei=Kishimoto en-aut-mei=Seibi kn-aut-name=岸本済美 kn-aut-sei=岸本 kn-aut-mei=済美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=国立岡山療養所 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=12-2 article-no= start-page=8319 end-page=8324 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Reduction Process of Bilirubin in the Intestine Part 2 Studies on the reduction of bilirubin by the fecal filtrate of the patient with the administration of antibiotics kn-title=腸管内bilirubinの還元過程に関する研究 第2編 抗生剤内服患者の屎濾液を以てするbilirubinの還元について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The separation of bilirubinoide in the anaerobic cultured solution of bilirubin with the fecal filtrate of the patient taking antibiotics and the cultured solution of the above fecal filrate in the phosphate pepton solution for 24hours under the anaerobic condition was attempted. And the results were as follows. 1. Indirect, direct bilirubin and mesobilirubin were separated at the 12th hour, same products at the 24th hour, dihydromesobilirubin and the above products at the 36th hour and urobilin and the above products at the 48th hour after the action of fecal filtrate to bilirubin, but only urobilin was identified after 72hours. 2. Indirect-, direct bilirubin, dihydromesobilirubin were separated at the 12th hour, indirect bilirubin and mesobilirubin at the 24th hour, dihydromesobilirubin at the 36th hour, and indirect bilirubin, mesobilirubin, dihydromesobilirubin and urobilin at the 48th hour after the anaerobic incubation of bilirubin with the cultured solution of a small amount of fecal filtrate in the phosphate pepton solution, but only urobilin was identified after 72hours. 3. Bilirubin was reduced to urobilinogen pasing though mesobilirubin, dihydromesobilirubin by anaerobic bacterial flora and it's reduction process was same to the reduction process of bilirubin by colloidal palladium, clarified by H. Fischer. en-copyright= kn-copyright= en-aut-name=ImaiHarujiro en-aut-sei=Imai en-aut-mei=Harujiro kn-aut-name=今井春路郎 kn-aut-sei=今井 kn-aut-mei=春路郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=12-1 article-no= start-page=7941 end-page=7955 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Iron and Copper Metabolisms in the So-Called Banti's Disease Part 1. On the Serum Iron and Copper Contents, Visceral Iron and Copper Contents, and the Iron and Copper Excreted in the Urine of Patients kn-title=所謂Banti氏病の鉄及び銅代謝にする研究 第1編 患者の血清鉄及び銅量臓器鉄及び銅量並びに尿中排泄鉄及び銅量に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=With 29 patients of the so-called Banti's disease the author carried out clinical investigations mainly on the iron and copper metabolisms, and obtained the following results. 1. In the patients suffering from this disease a decrease in the serum iron content and an increase in the serum copper content can be recognized. 2. In this diseasa the deerease in visceral iron fractions, PI and PII in the liver, is marked, while in the spleen although PII is decreased, PI, on the contrary, is increased. 3. In this disease the gram unit content of visceral copper in the liver is increassed when compared with that in the spleen. 4. The iron content excreted in the urine of this disease is less than that in normal persons, whereas the copper content is greater than that in normal persons. 5. At the time of ACTH-gel test the decrease in the serum iron content and the increase in the serum copper are more marked in the patient than those in normal persons, while on the day and second day of the test the iron and copper contents excreted in the urine of the patient do not decrease so markedly as those in normal person. 6. The serum iron content five minutes after the iron tolerance test shows a lower value in the patient than that in normal person, and likewise the serum copper content shows somewhat a similar decrease. 7. On the basis of these findings the author discussed from various angles the iron and copper metabolism in the patient with this disease. en-copyright= kn-copyright= en-aut-name=OkadaYoshio en-aut-sei=Okada en-aut-mei=Yoshio kn-aut-name=岡田由夫 kn-aut-sei=岡田 kn-aut-mei=由夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=11-2 article-no= start-page=7803 end-page=7812 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Oxidation-Reduction Potential and the Bilirubin Deposition of Skin in Jaundiced Patients Part II. Studies on the Bilirubin Deposition of Skin in Jaundiced Patients kn-title=黄疸患者の皮膚の酸化還元電位とbilirubinの沈着に関する研究 第2編 黄疸患者の皮膚に於けるbilirubinの沈着に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to clarify the deposited region of bilirubin and the cause of green tone in the skin of jaundiced patients, the author made the histochemical observation, employing the frezing-drying and also made the observation on the stainability of both fibers, being chiefly composed by collagen and elastoid, to the serum of jaundiced patient and various bilibubin solutions in vitro, using the tail's tendon of young white rat. And the results were as follows. 1. The author applied the freezing-drying to the histochemical studies on the skin stained by bilirubin and got the satisfactory results. 2. As for the staining condition of bilirubin in the skin of jaundiced patient, it was diffuse, but not the paticular region or fiber. 3. Staining the fiber, being chiefly composed by collagen and elastoid, by each solution of cristallin bilirubin, bilirubin soda salt, natural salt-form and ester-form bilirubin and serum of jaundiced patients in the buffer solutions with various pH value, the stainability was the best on the use of ester-form bilirubin and the best pH value was 7.0, and the deposited bilurbin was easily changed to biliverdin on the shift of pH to alkaline side. 4. Staining the above both fibers by biliverdin as same as bilirubin, it's staining deposition was the same degree with that of bilirubin. 5. Therefore, the staining deposition of skin in jaundice was not in the elastin of elastic fiber as put forward by F. Rosenthal, it was diffusely seen in the whole of skin and it was rather strong in the collagenous fiber than elastoid. Shifting the pH of skin to akaline side, the deposited bilirubin was easlly changed to biliverdin and Verdinikterus was occured from it. en-copyright= kn-copyright= en-aut-name=IshimitsuTetsusaburo en-aut-sei=Ishimitsu en-aut-mei=Tetsusaburo kn-aut-name=石光鉄三郎 kn-aut-sei=石光 kn-aut-mei=鉄三郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=11-2 article-no= start-page=7783 end-page=7802 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Oxidation-Reduction Potential and the Bilirubin Deposition of Skin in Jaundiced Patients Part I Studies on the Oxidation-Reduction Potential of Skin in Jaundiced Patients kn-title=黄疸患者の皮膚の酸化還元電位とbilirubinの沈着に関する研究 第1編 黄疸患者の皮膚の酸化還元電位に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to clarify the condition of oxidation-reduction potential in the skin of jaundiced patients, the author made the preliminary experiment by the injection of 2. 3. 5. triphenyl tetrazolium chloride, neo tetrazolium chloride and blue tetrazolium into dogs and rabbits, employing the Arakawa's method, and it was recognized the T. T. C. test by Arakawa was the best method to apply to human body. Therefore, the test was attempted on 20 cases of healthy human, 110 cases of various liver and bile ducts diseases (75 cases of them showed hyperbilirubinemia over 1 mg/dl) and 21 cases of other diseases, and the above results was compared with various clinical symptoms and clinical courses. And the results were as follows. 1. Using the above agents as a oxidation-reduction. dicator of skin in living body, the sensitivity was in order of N. T C., T. T. C. and B. T., but the side effect was the most scanty in T. T. C., Therefore, the T. T. C. test by Arakawa was the best for the application to human body, and N. T. C. had the utility value on the animal experiment since the stability and sensitivity to light, but B. T. could not use. 2. The difference of oxidation-reduction potential among healty human, dog and rabbit was clearly observed, and this test was the most in rabbit, and then in dog, and the most low in human. 3. The T. T. C. test was almost negative in healthy human, but in was positive in all cases of mechanical jaundice, and it showed positive by the stadium or symptom in acute hepatitis and livercirrhosis, and it was seen at the early period of acute stadium in the former and it was seen in the cases of the latter with continuous jaundice over 60 days. In and it was negative or slight positive in chronic hepatitis. It was negative in hemolytic jaundice and others. 4. Comparing T. T. C. test with various clinical symptoms and various clinical tests, it had relation to serum total bilirubin especially direct bilirubin, alkaline phosphatase and skin itching, and it had considerable relation to serum colloidal reaction in acute hepatitis and BSP-test. 5. Therefore, it was thought that there were close correlation between the oxidationreduction potential of skin and the mechanism in which Verdinikterus was occured from the change of disposed bilirubin in skin to biliverdin. en-copyright= kn-copyright= en-aut-name=IshimitsuTetsusaburo en-aut-sei=Ishimitsu en-aut-mei=Tetsusaburo kn-aut-name=石光鉄三郎 kn-aut-sei=石光 kn-aut-mei=鉄三郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=11-2 article-no= start-page=7643 end-page=7651 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Metabolism of Pyro-Racemic Acid in Lung Tuberculosis Part II Studies on the Influence of Various Vitamin to the Vicissitude of Pyro-Racemic Acid in Urine, in Lung Tuberculosis kn-title=肺結核患者の焦性ブドー酸代謝 第2編 肺結核患者における尿中焦性ブドー酸の消長に及ぼす各種ビタミンの影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influence of glucose and various vitamin to the excreted dosis of pyro-racemic acid in urine was observed on 40 cases (male 19, female 21) of lung tuberculosis. And the results were as follows. 1. The dosis of vitamin B(1) and B(2) in urine for one day had relation to the severity of disease and the excreted dosis of visamin B(1) and B(2) into urine decreased with severe case. 2. The decrease of the excreted dosis of pyro-racemic acid in urine was observed on the 30 cases of 40 cases with the intravenous injection of 20% glucose 0.1 cc per kg and it was observed on the 20 cases of 40 cases with the administration of 20% glucose 0.2 cc per kg. In other words, glucose activated the disposal function of Pyro-racemic acid in some degree. And at that time, the considerable correlation between the severity of disease and the above function was observed, but it had no relation with cavity, excretion of bacillus, erythrocyte sedimentation rate liver function or subjective symptoms. 3. Giving vitamin B(1) 5 mg at 1 hour before the administration of 20% glucose 0.2 cc per kg, the decrease of pyroracemic acid was observed on the 6 cases of 20 cases which did not show the decrease or pyro-racemic acid, and it was shown in the 4 more cases on the use of cocarboxylase 5 mg instead of vitamin B(1). Furthermore, it was seen in the 4 cases of 10 cases, which did not show the decrease of pyro-racemic acid on the use of cocarboxylase, on the mixed use of cocarboxylase and vitamin B(2) 5 mg and it was seen in the 6 cases of them on the use of cocarboxylase and glucose after the adminstration of pantotenic acid calcium 200 mg for 3 day. The above cases included the 4 cases showing the decrease on the mixed use of vitamin B2. And it was seen in the 6 cases of them on the administration of thioctic acid 10 mg at 1 hour the administration of glucose, and the 3 cases of them were same to the cases showing the decrease on the mixed use of cocarboxylase and pantotenic acid and other 3 cases was the cases which did not show the decrease on the mixed use of the above drugs. And the decrease of pyro-racemic acid was seen in all of 10 cases on the mixed use of thioctic acid 10 mg and glucose. 4. The disposition of pyroracemic acid became smooth by the addition of cocarboxylase, pantotenic acid and thioctic acid etc. with the combination of phosphorus in vitamin B1 in lung tubercuosis. In other words, the latent deficiency of vitamin and enzyme, especially the deficiency of thioctic acid, was noticed. en-copyright= kn-copyright= en-aut-name=NakanishiYoji en-aut-sei=Nakanishi en-aut-mei=Yoji kn-aut-name=中西洋二 kn-aut-sei=中西 kn-aut-mei=洋二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=11-2 article-no= start-page=7635 end-page=7641 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Metabolism of Pyro-Racemic Acid in Lung Tuberculosis Part I Studies on the Vicissitude of Pyro-Racemic Acid in Urine and the Influence of Vitamin B to it, in Lung Tuberculosis kn-title=肺結核患者の焦性ブドー酸代謝 第1編 肺結核患者における尿中焦性ブドー酸の消長とこれに及ぼすビタミンBの影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The vicissitude of B. T. S. dosis in urine and the infuluence of vitamin B to it were observed on 20 cases of female lung tuberculosis patients of various degree to severe cases from mild cases with the administration of glucose. And the results were as follows. 1. Vitamin B(1) and B. T. S. in urine decreased after the administration of 20% glucose 20 cc, in the 5 cases of 20 cases, and those were mild moderate cases. The cases showing the increase of them were moderate and severe ones. 2. B. T. S. in urine increased after the administration of 50% glucose 20 cc, in all cases. 3. In mild cases, the disposal function of B. T. S. was activated with the fixed dosis of glucose, but the function was not activated with the excess dosis of glucose. 4. The decrease of B. T. B. dosis in urine was observed on the 5 cases of the 15 cases, which did not show the decrease of B. T. B. dosis on the administration of glucose only, with the intravenous administration of vitamin B(1) 5 mg at 1 hour before the administration of 20% glucose 20 cc. 5. The cases which did not show the decrease of B. T. S. dosis in urine by the administration of vitamin B1 was mostly severe cases and most of the cases showed liver damage, promotion of erythrocyte sedimentation reaction and positive bacillus in sputum. 6. The correlation between the Sawada's reaction and the vicissitude of B. T. S. dosis urine was not always observed. 7. No difference between the simple use of vitamin B1 5 mg and the mixed use of vitamin B(1) and B(2) 5 mg was observed. 8. Using T. O. E. D. 20 mg instead of vitamin B(1) 5 mg by intravenous injection, the effect was observed on the 3 cases of 10 cases without the effect of vitamin B(1) 5 mg. In other words, it was understood that there were cases with lack of vitamin B(1) in cases of lung tuberculosis. 9. No differences among the mixed use of T. O. E. D. and vitamin B(2) grucuronic acid soda and the simple use of T. O. E. D. were observed. en-copyright= kn-copyright= en-aut-name=NakanishiYoji en-aut-sei=Nakanishi en-aut-mei=Yoji kn-aut-name=中西洋二 kn-aut-sei=中西 kn-aut-mei=洋二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=8-2 article-no= start-page=5163 end-page=5172 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590815 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Influences of the Bacterial Infection upon the Hematopoietic Mechanism in Bone Marrow chiefly by means of Bone-Marrow Tissue Culture Part 3. Results of the Bone-Marrow Tissue Culture of Patients with Subacute Bacterial Endocarditis kn-title=細菌感染の骨髄造血機転に及ぼす影響に関する研究―主として骨髄組織培養による― 第3編 悪急性細菌性心内膜炎患者の骨髄組織培養成績に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the bone-marrow tissue culture of the patients with subacute bacterial endocarditis the author obtained the following results: 1. In the case of cover-slip culture, the relative growth rate is normal both before and and after the treatment of patients, but the cell-density index is normal or in some cases with a decrease in bone-marrow nucleated cells it is diminished. 2. In the case of the tissue culture in a fluid medium, the increasing rate of erythrocytes, reticulocytes, and hemoglobin is markedly low before the treatment, but it recovers with treatment. 3. The wandering velocity of neutrophils in the bone marrow has been found to be normal or slightly accelerated. 4. The carbon-particle phagocytotic ability of neutrophils in the bone marrow is markedly decreased before the treatment, but it recovers to normal when the patient is treated. 5. As for the neutral-red vital staining of bone-marrow neutrophils, these cells stain quickly and deeply, indicating a decrease in the functions, but this condition is restored to normal by treatment. In the present paper the author stated that the examinations of the bone marrow by tissue culture with emphasis on the carbon-particle phagocytosis served a quite significant purpose for clinical course observations. en-copyright= kn-copyright= en-aut-name=NaitoTakakazu en-aut-sei=Naito en-aut-mei=Takakazu kn-aut-name=内藤孝和 kn-aut-sei=内藤 kn-aut-mei=孝和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=8-2 article-no= start-page=5025 end-page=5040 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590815 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on LEUKEMIA Part 1. Clinical Statistics of Leukemia Admitted in the Leading Hospitals in the Chugoku-Shikoku District kn-title=白血病に関する臨床的研究 第1編 中国四国地方主要病院入院白血病患者の臨床統計 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to take the statistics of clinical records of leukemia, the author analyzed the total of 242 cases of leukemia admitted in the leading hospitals of the Chugoku-Shikoku District (excluding Hiroshima Prefecture) and obtained the following results. 1. The total cases of leukemia can be divided into 88 cases of acute myelogenous leukemia, 70 cases of chronic myelogenous leukemia, 48 cases of acute lymphocytic leukemia, 4 cases of chronic lymphocytic leukemia, 2 cases of erythro-leukemia, 17 cases of monocytic leukemia, 8 cases of unclassified acute leukemia, and one completely unclassified case. 2. As for the difference in the incidence by sex, the male occupies 62 per cent of the whole, but 75 per cent of lymphocytic leukemia proving to occupy a far greater proportion of male whereas in monocytic leukemia the female occupies a far greater proportion as much as 53 per cent. 3. As for the age distribution those under 25 years of age occupy the majority. According to the types, in the acute leukemia, especially in lymphocytic leukemia the greater part is occupied by younger persons, while in chronic leukemia those in the age range between 35-and 39 years present the peak, and even in the age beyond this range can be found quite many cases. The same also applies to monocytic leukemia. 4. No characteristic feature attributable to occupation can be recognized. 5. There have been 3 cases (1.3%) showing family history of leukemia and 17 cases (7.0%) showing family history of cancer. 6. There are included 5 cases of atomic bomb survivors. As for the anamnestic history there are 6 cases of malaria and 5 cases each of pleurisy and pneumonia. 7. When the symptoms at the Onset of the disease such as subjective complaints and somatic symptoms are arranged in the order of the frequency by the types, they are as follows. Initial symptoms: in acute myelogenous leukemia: fever, general malaise, anemia, hemorrhagic tendency; in acute lymphocytic leukemia: fever, general malaise, anemia, the swelling of the lymph nodes, and pain; in chronic myelogenous leukemia: general malaise, the swelling of spleen, anemia, bulging of the abdomen, fever; in monocytic leukemia: fever, general malaise and hemorrhagic tendency. Subjective complaints: In acute myelogenous leukemia: fever, bleeding tendency, anemia, general malaise; in acute lymphocytic leukemia: fever, anemia, swelling of the lymph nodes, general malaise, hemorrhagic tendency; in chronic myelogenous leukemia: tumor in the abdomen, (bulging of the abdomen and swelling of the spleen), general malaise, fever, anemia, pain; in monocytic leukemia: fever, general malaise, bleeding tendency, anemia, and pain. Somatic symptoms: in acute myelogenous leukemia: anemia, fever, general malaise, fatigue, general emaciation; in acute lymphocytic leukemia: anemia, fever, general malaise, fatigue, emaciation; in chronic myelogenous leukemia: anemia, general malaise, fatigue, fever, emaciation: in monocytic leukemia: anemia, fever, general malaise, fatigue and general emaciation. 8. Dilatation of lymph nodes and swelling of the spleen can be found in 77.3 per cent and 49.0 per cent respectively of acute myelogenous leukemia: in 93.8 and 66.7 per cent of acute lymphocytic leukemia; in 61.5 and 94.3 per cent of chronic myelogenous leukemia; in 100.00 and 100.0 per cent in chronic lymphocytic leukemia; and in 76.4 and 23.5 per cent of monocytic leukemia, especially the enlargement of the spleen in chronic myelogenous leukemia is marked. 9. Hemorrhagic tendency can be observed in 70 per cent of acute myelogenous leukemia and acute lymphocytic leukemia, and in 40-60 per cent of other types. 10. Symptoms of the digestive organs are stronger in acute leukemia than in chronic leukemia. In the latter the feeling of bulging abdomen is frequent, while in acute myelogenous leukemia and monocytic leukemia stomatitis and buccal ulcers are more frequently encountered. en-copyright= kn-copyright= en-aut-name=NagamatsuHiroshi en-aut-sei=Nagamatsu en-aut-mei=Hiroshi kn-aut-name=永松洋 kn-aut-sei=永松 kn-aut-mei=洋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=8-2 article-no= start-page=5007 end-page=5024 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590815 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Investigation on Thiamine Metabolism in Rheumatoid Arthritis kn-title=リウマチ患者のビタミンB(1)代謝に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinical investigation regarding to vitamin B(1) metabolism was performed on rheumatoid arthritis during one month of admission, during which period the various antirheumatic agents were given to these patients. 1) The total thiamine levels of blood in rheumatoid arthritis was low compared with normal healthy people, specifically low in ester type suggesting the decrease of phosphorylation. There was also present the advancements of erythrocyte sedimentation rate and disturbed function of liver with advance of "stage" and "class" of this disease. The decrease of rate of phosphorylation was seemed to be parallel to them. 2) It is able to consider that the vitamin B(1) deficient of rheumatoid arthritis is due to the decrease of vitamin B(1) level in blood resulted from the lower efficiency of vitamin utilization. 3) It is concluded from the observations of clinical symptoms at the rheumatoid arthritis that as the temporary elevation of vitamin B(1) level in blood by administration of large dosage of vitamin B(1) appears to be insufficient in analgetic activity for rheumatoid arthritis, so it seems better in the treatment by corticoids with small dosage of vitamin B(1) administration for long period rather than by large dosage for short period. 4) For the improvement of vitamin B(1) metabolism, thiamine propyl disulfide and cocarboxylase are more effective than the other, and the combind administration of vitamin B(1) with ATP was effective, specifically for the elevation of ester type of vitamin B(1). It will be concluded that the protecting treatment of liver function is also useful not only for elevation of the value of vitamin B(1) in blood but also for the improvement of general symptoms of rheumatoid arthritis. en-copyright= kn-copyright= en-aut-name=KodamaHiroshi en-aut-sei=Kodama en-aut-mei=Hiroshi kn-aut-name=児玉寛 kn-aut-sei=児玉 kn-aut-mei=寛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部整形外科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=8-1 article-no= start-page=4613 end-page=4627 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590810 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Adrenal Cortical Function in Hypoplastic Anemia Part 3. The Function of Adrenal Cortex of Patients with this Disease kn-title=再生不良性貧血における副腎皮質機能に関する研究 第3編 患者の副腎皮質機能 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With a view to clarify the cause of hypoplastic anemia the author studied the adrenal cortical function in patients with this disease, and obtained the following results. 1. The basic metabolic rates show not any definite inclinations. 2. In the insulin tolerance test, the insulin index has been found to have declined. 3. As for electrolytes in serum, chlorine is decreased but phosphorus is increased to a high degree, and ratio Na/K is slightly high while calcium, sodium and potassium show no definite inclinations. 4. Robinson-Power-Kepler water test is almost positive. 5. On measuring 17-KS and free chemocortioids (Ch. C.) excreted in the urine, the amount of 17-KS is decreased conspicuously but Ch. C. is increased. 6. In the gel-ACTH loading test the adrenal cortical reserve function has been found to have declined highly. 7. From these facts stated above, it is possible to assume that there is a decline in the adrenal cortical function in this disease. en-copyright= kn-copyright= en-aut-name=KurozumiJiro en-aut-sei=Kurozumi en-aut-mei=Jiro kn-aut-name=黒住治郎 kn-aut-sei=黒住 kn-aut-mei=治郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=4-1 article-no= start-page=1347 end-page=1367 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Vital Observations on the Movement of the Spceific Granules of Granulocytes in Bone-Marrow Tissue Culture Part 3. A Study on Neutrophils and Eosinophils in Normal Persons and Patients with Various Diseases kn-title=骨髄体外組織培養に於ける顆粒球の固有顆粒運動の生態観察 第3編 健康人並びに各種疾病患者の好中球，好酸球に就て 附．全編の総括 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the bone-marrow tissue culture of the sternal bone marrow obtained from normal persons and patients with various diseases the author observed the granular movements of neutrophils and eosinophils with the aid of the phase-contrast microscope, and obtained the following results: 1. The granular movements of neutrophils and eosinophils in normal persons do not differ much from those in normal rabbits, but in the granules of neutrophils can be observed a movement more minute than in pseudoeosinophils, and the molecular movement can be recognized relatively frequently in the granules of eosinophils. 2. In neutrophils and eosinophils of the cases with hyperfunction of the thyroid gland, the granular movements are vigorous, and a marked acceleration in the motility of cells can be recognized. 3. In neutrophils and eosinophils of hypoplastic anemia. myxedema, cachexia from the stomach cancer, and chronic myelogenous leukemia the granular movement has been found to have slackened in all with a resultant decrease in the cell motility, and this decrease in the functions is most marked in hypoplastic anemia. 4. In the case of eosinophils in anchylostomiasis and bronchial asthma the acceleration of the cell motility can be recognized from the modes of the granular movements. Especially in the eosniphilic granules in anchylostomiasis an abnormal acceleration in the motility can be observed, showing a marked semi-radial linear forward movement of granules. 5. As has been noted in the previous report, the reverse-flow of granaules in the tail end at the early stage of the movement cycle can be seen frequently in the hyperfunction of the thyroid gland (neutrophils and eosinophils), bronchial asthma (eosinophils), and anchylostomiasis (eosinophils), in which already known that the cell motility is accelerated. In contrast to these. the reverse flow movement of granules in the tail end at the terminal stage of the cycle can be observed frequently in hypoplastic anemia and chronic myeolgenous leukemia (all neutrophils and eosinophils), apparetnly showing the decreased functions. 6. From the relationship between the appearance of the reverse-flow movement of grauules in the tail end and the cycle of the cell movement it is possible to estimate the conditions of the cell motility, and clinically ths application of this estimation will offer some criteria for the differential diagnosis and the prognosis of diseases. en-copyright= kn-copyright= en-aut-name=AndoSaburo en-aut-sei=Ando en-aut-mei=Saburo kn-aut-name=安東三郎 kn-aut-sei=安東 kn-aut-mei=三郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=5-6 article-no= start-page=529 end-page=540 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Malignant neoplasms among patients with certified chronic arsenic poisoning in Toroku kn-title=土呂久における慢性ヒ素中毒認定患者の悪性新生物についての疫学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=An epidemiological study has been made to assess the carcinogenic effect of arsenic exposure by analyzing a group of patients with certified chronic arsenic poisoning at “Toroku”, a small mountainous village in Japan. The number of deaths from cancer of the respiratory system and cancer of bladder, kidney and other and unspecified urinary organs showed a significant excess over the expected value, compared with expected number of deaths, based on sex and age-specific mortality of Japanese in 1975, 80 and 85. The number of patients from all cancers, respiratory cancer and urinary tract cancer showed a significant exess of former workers, using data classified by employment history. Classified by employment history and smoking habits, the number of respiratory cancers showed a significant excess only in the cohort of former workers with a smoking history. This finding suggests that there is an interaction between exposure to arsenic and smoking. Eleven of seventeen cancer cases were accompanied by cancer of other organs, including Bowen's disease. These results demonstrated that a follow-up study on these patients should be conducted with a particular emphasis on cancers. en-copyright= kn-copyright= en-aut-name=TsudaToshihide en-aut-sei=Tsuda en-aut-mei=Toshihide kn-aut-name=津田敏秀 kn-aut-sei=津田 kn-aut-mei=敏秀 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳代謝研究施設病態生化学部門 en-keyword=ヒ素 kn-keyword=ヒ素 en-keyword=産業中毒 kn-keyword=産業中毒 en-keyword=疫学 kn-keyword=疫学 en-keyword=悪性新生物 kn-keyword=悪性新生物 en-keyword=公害 kn-keyword=公害 END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=1-2 article-no= start-page=175 end-page=187 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Discriminant analysis of asthmatic patients and healthy adults using maximal expiratory indices kn-title=”喘息患者の最大呼気指標による判別分析”―有効な指標の選択― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The selection of effective maximal expiratory was evaluated using discriminant analysis of asthmatic patients and healthy adults in this review. Maximal expiratory volume-time and flow-volume (MEVT and MEFV) curves were drawn for young non-smoking healthy subjects and for young male non-smoking asthmatic patients. Eleven indices, two MEVT (%FVC and FEV(1.0%)), six MEFV (PEFR, Flow(75), Flow(50), Flow(25), Flow(10) and Flow(50)/Flow(25)) and three mean time constant (MTC) indices (MTC(75-50), MTC(50-25) and MTC(25-RV)) were used for the discriminant analysis using an all possible selection procedure (APSP). In the eleven-indices discriminant analysis using a single index, Flow(75), Flow(50) and Flow(25) were effective indices. In the discriminant analysis through APSP, PEFR, Flow(75), MTC(75-50) and FEV(1.0%), which were at high lung volumes, were the set of the most effective four indices. These four indices appear to be effective in assessing bronchial asthma through a visual evaluation of MEFV curves. Therefore, discriminant analysis is appropriate in assessing the MEFV curves. en-copyright= kn-copyright= en-aut-name=MeguroTadamichi en-aut-sei=Meguro en-aut-mei=Tadamichi kn-aut-name=目黒忠道 kn-aut-sei=目黒 kn-aut-mei=忠道 aut-affil-num=1 ORCID= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=緒方正名 kn-aut-sei=緒方 kn-aut-mei=正名 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=MEFV曲線 kn-keyword=MEFV曲線 en-keyword=最大呼気指標判別分析 kn-keyword=最大呼気指標判別分析 en-keyword=最良選択法 kn-keyword=最良選択法 END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue= article-no= start-page=31 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Studies on Anemia in Rheumatoid Arthritis (II) kn-title=関節リウマチの貧血に関する臨牀的研究 第2報： 関節リウマチ患者の血清鉄量の消長について. 付血清銅量 en-subtitle= kn-subtitle= en-abstract= kn-abstract=II. Iron Metabolism 1. The serum iron: The serum iron was estimated by the method of Umemoto and Yamamoto (by means of o-nitroso resorcinmonomethylether) The average serum iron level of 33 cases with rheumatoid arthritis was 47γ/100 ml., and in 27 of 33 cases (82%) the serum iron levels were shown to be below　the lower limit of the normal range (5% rejection limit: 54-141γ/100 ml. ), but the concentrations of serum iron of neuralgias (degenerative Spondylosis, sciatica and painful shoulder) were mostly within the normal range. 2. Iron absorption: To investigate the possible role of poor absorption in preventing a response to oral iron therapy, the changes in serum iron were followed after a test of iron by mouth in 16 caseS with rheumatoid arthritis. The test dose was 1 gm. of reduced iron given with 30 mI. of lemonade-pepsin solution to preserve the iron in the ferrous state and obviate the effects of possible achlorhydria in rheumatoid patients. The results may be grouped under three headings: a) Large rise in serum iron: good adsorption. Three caseS (19%) showed a very large rise in serum iron after the test dose, which is similar to simple iron-deficiency anemia. b) Slight rise in serum iron: presumed poor absorption. Six cases (38%) showed a very small or negligible rise after the test dose, so that at its peak the serum iron was below the normal range. c) In the remaining 7 cases, a maximal rise in serum iron after the test dose was within the normal range. 3. The iron-binding capacity of the serum: The iron-binding capacity of the serum was estimated by means of intravenous injection of Gluferricon (Fe content: 10 mg.). The mean total iron-binding capacity of the serum in the present 13 cases with rheumatoid arthritis was 273γ/100ml., virtually the same as the normal figure (287γ /100 ml.). The degree of saturation of the iron-binding protein with iron was found to lie between 18 and 45% (average: 34%) in control sUbjects and between 7 and 24% (average: 16%) in rheumatoid patients. 4. The serum copper: The serum copper was estimated by means of diethyldithiocarbamate in rheumatoid arthritis with the following results. Healthy subjects: men (15 cases): mean 89.9±14.8γ /l00 ml., women (15 cases): mean 99.9± 12.6γ/100 ml. There is no significant difference between the two. In 10 of 17 cases (57%) with rheumatoid arthritis, the serum copper levels were shown to be above the upper limit of the normal range (57-138γ/100 ml. ・・・5% rejection limit), neuralgias were mostly (92%) within the normal range. The results of investigations upon alternations in iron metabolism of rheumatoid anemia are reported. 1. The serum iron concentration was usually reduced. 2. The intestinal absorption of iron after a single dose of 1 gm. of reduced iron was variable. Strong presumptive evidence of impaired absorption waS recognised in many cases, but some cases gave the excellent absorption. From these results, it seems that simple iron deficiency exist in some anemic caseS of rheumatoid arthritis. 3. The total iron-binding capacity of the serum was slightly reduced. 4. The degree of Saturation of iron-binding protein with iron was below nornal. 5. The serum copper concentration waS usually elevated. en-copyright= kn-copyright= en-aut-name=YamamotoYasuhisa en-aut-sei=Yamamoto en-aut-mei=Yasuhisa kn-aut-name=山本泰久 kn-aut-sei=山本 kn-aut-mei=泰久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所内科 END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=13 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on electromyographic changes in rheumatoid arthritis Part II. Electromyographic changes in treated rheumatoid arthritis during 3 months after admission kn-title=慢性関節リウマチの筋電図に関する臨床的研究 第II編. 慢性関節リウマチ患者の治療に伴う筋電図の変動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Electromyograms were recorded on 15 patients with rheumatoid arthritis (12 cases of classical rheumatoid arthritis and 3 cases of definite rheumatoid arthritis) and 5 cases of healthy controls. The muscles selected were the biceps brachii, opponens pollicis and abductor pollieis brevis, and following results were obtained: 1) The amplitude and mean potential duration in rheumatoid arthritis were less than controls, the differences being statistically significant. 2) Electromyographic evidence of myogenic atrophy was demonstrated in the small hand muscles and proximal muscles. 3) Myogenic atrophy due to steroid therapy was considered in proximal muscles, while the small hand muscles were affected more rarely. 4) Myogenic atrophy in stage III-IV were less than those in stage I-II, but in the m. opponens pollicis there were little differences. 5) Myogenic atrophy in inactive rheumatoid arthritis were significantly less than those in active, but in the m. opponens pollicis no marked changes were observed. 6) Myogenic atrophy of the m. opponens pollicis were more than that of m. abductor pollicis brevis. en-copyright= kn-copyright= en-aut-name=IkegamiTadaoki en-aut-sei=Ikegami en-aut-mei=Tadaoki kn-aut-name=池上忠興 kn-aut-sei=池上 kn-aut-mei=忠興 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉医学部門 END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=1 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on electromyographic changes in rheumatoid arthritis Part I. Electromyographic changes in rheumatoid arthritis kn-title=慢性関節リウマチの筋電図に関する臨床的研究 第l編. 慢性関節リウマチ患者の筋電図 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Electromyograms were recorded on 15 patients with rheumatoid arthritis (12 cases of classical rheumatoid arthritis and 3 cases of definite rheumatoid arthritis) and 5 cases of healthy controls. The muscles selected were the biceps brachii, opponens pollicis and abductor pollieis brevis, and following results were obtained: 1) The amplitude and mean potential duration in rheumatoid arthritis were less than controls, the differences being statistically significant. 2) Electromyographic evidence of myogenic atrophy was demonstrated in the small hand muscles and proximal muscles. 3) Myogenic atrophy due to steroid therapy was considered in proximal muscles, while the small hand muscles were affected more rarely. 4) Myogenic atrophy in stage III - IV were less than those in stage I·II, but in the m. opponens pollicis there were little differences. 5) Myogenic atrophy in inactive rheumatoid arthritis were significantly less than those in active, but in the m. opponens pollicis no marked changes were observed. 6) Myogenic atrophy of the m. opponens pollicis were more than that of m. abductor pollicis brevis. en-copyright= kn-copyright= en-aut-name=IkegamiTadaoki en-aut-sei=Ikegami en-aut-mei=Tadaoki kn-aut-name=池上忠興 kn-aut-sei=池上 kn-aut-mei=忠興 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉医学部門 END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page=1 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=1971 dt-pub=19710326 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on electromyographic changes in rheumatoid arthritis Part III. Effect of radioactive hot spring baths kn-title=慢性関節リウマチの筋電図に関する臨床的研究 第III編 慢性関節リウマチ患者の温泉入浴に伴う筋電図の変動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author observed the changes in electromyographic patterns of 14 patients with rheumatoid arthritis (13 cases of classical rheumatoid arthritis and one case of definite rheumatoid arthritis) bathed 2 or 3 times daily in hot spring water at Misasa Spa, at a temperature of 40±1℃, 5-10 minutes. The electromyographic examination was performed on the biceps brachii, opponens pollicis and the abductor pollicis brevis. Intramuscular temperature was measured in the deltoid muscle. The results were as follows. 1) The intramuscular temperature in cases of rheumatoid arthritis did not deviate from normal subjects. 2) After the general spring bathing the intramuscular temperature increased about 1℃ and it had no difference between the patients with rheumatoid arthritis and normal subjects. 3) With increasing intramuscular temperature by the general spring bathing in cases of active rheumatoid arthritis the mean potential amplitude decreased and the mean potential duration increased. 4) With increasing intramuscular temperature by the general spring bathing in cases of inactive rheumatiod arthritis the mean amplitude increased and the mean duration decreased. 5) The patterns of potential duration and amplitude before and after a bath on re-examination, one month after a series of the general spring baths, showed a tendency of reverse of the initial patterns. 6) After two months of a series of the general spring baths, the patterns of electromyographic changes of patients with rheumatoid arthritis following the bathing were similar to the initial patterns. en-copyright= kn-copyright= en-aut-name=IkegamiTadaoki en-aut-sei=Ikegami en-aut-mei=Tadaoki kn-aut-name=池上忠興 kn-aut-sei=池上 kn-aut-mei=忠興 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉医学部門 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ループス腎炎患者の腎組織における予後予測スコアの臨床的有用性 kn-title=Clinical Usefulness of a Prognostic Score in Histological Analysis of Renal Biopsy in Patients with Lupus Nephritis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KojoShoichiro en-aut-sei=Kojo en-aut-mei=Shoichiro kn-aut-name=古城昭一郎 kn-aut-sei=古城 kn-aut-mei=昭一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=25 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The involvement of ear and throat in rheumatoid arthritis II. On the Rheumatoid Arthritis of Cricoaryenoid Joint kn-title=慢性関節リウマチの耳科･咽喉科領域における障害について 第2報 : 慢性関節リウマチ患者の喉頭所見について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Until 1955 a few reports had been made concerning this problem. On December 1955. Montgomery, Perone and Schall reported four cases of rheumatoid arthritis of cricoarytenoid joint. It seemed to have interested other authors so that Saunders, Pearson, BakerBywaters, Copeman and Polisar reported their clinical findings. In 1957 Pearson presented a histological section of cricoarytenoid joint, showing villous synovial proliferation. In 1959 Montgomery reported another series of additional cases and microscopical findings of the cricoarytenoid joint of two patients with rheumatoid arthritis. This study did not show a complete fibrous ankylosis but severe arthritic changes were seen. In the same year Copeman et al. reported an autopsy case of rheumatoid arthritis with ankylosis of cricoarytenoid joint. In early 1960's Grossman et al. examined 55 patients with rheumatoid arthritis and found 18 patients with some suggestive evidence of cricoarytenoid arthritis. Lofgren and Montgomery examined 100 patients of rheumatoid arthritis, finding 26% of them had involvement of cricoarytenoid joint. They stated that this disease seemed to be more common and more severe in female. Bienenstock stated 17 cases of 64 randomly selected patients with rheumatoid arthritis had one or more symptoms considered to be characteristic of cricoarytenoid arthritis. He claimed that arthritis of cricoarytenoid joint occured much more frequently in patients with rheumatoid arthritis than had been suspected. At postmortem examination Grossman saw histological changes of cricoarytenoid joint characteristics of rheumatoid arthritis in 5 of 11 autopsied patients with rheumatoid arthritis and Bienenstock found the same in 7 of 8 patients. In 1963 for the third time Montgomery discussed of cricoarytenoid arthritis, based on his own experiences and many available literatures. Pathologic changes range between the mere synovial thickning and the complete disruption. Montgomery believed as others did, that in ankylosing chronic stage inspiratory bowing of both vocal cords and absolute fixation of arytenoid cartilage were diagnostic signs of rheumatoid arthritis of cricoarytenoid joint. In 1958 Darke, Wolman and Young reported five cases of laryngeal stridor, where in four cases tracheotomy became necessary. Two of them were brought to autopsy and histological examination. They found evidence of the nerve degeneration and mobile cricoarytenoid joint. The cause of nerve degeneration in the second case was an ischaemic neuropathy from rheumatoid arteritis of vasa nervorum. These findings were different from those of Montgomery and others. In 1965 Wolman, Darke and Young had an opportunity of six more autopsy examples. They confirmed from their own pathologic findings that laryngeal stridor occuring in rheumatoid arthritis was due mainly to arteritis of the vasa nervorum causing ischaemic neuropathy and that polymyositis and joint disease might augment this effect. Woldorf and Webb et aI. introduced both of these opinions. Anyhow, in U. S. A. and in England 25%-28% of rheumatoid arthritis seems to have rheumatoid arthritis of cricoarytenoid joint. On the other hand in our country there has been seen no report on rheumatoid arthritis of cricoarytenoid joint. In order, therefore, to investigate this problem author examined in medical clinic of Misasa branch hospital of Okayama university school of medicine 76 patients of classical and definite rheumatoid arthritis. Their complaints were as follows. 1) dryfeeling of throat 17 (22.4%) 2) slight hoarseness 11 (14.5%) 3) choking by long conversation 1 (1.32%) 4) slight dysphagia 2 (2.6%) The larynx was mirrored indirectly by Türk's, Killian's and Avellis's position. Any redness, swelling of mucous membrane, abnormality of vocal cords and arytenoid cartilage were not found. en-copyright= kn-copyright= en-aut-name=OdaRei en-aut-sei=Oda en-aut-mei=Rei kn-aut-name=小田昤 kn-aut-sei=小田 kn-aut-mei=昤 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=2 article-no= start-page=143 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Sanyo-area Network for patients with intractable neurological disorders kn-title=山陽地区神経難病ネットワークの活動 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuuraTohru en-aut-sei=Matsuura en-aut-mei=Tohru kn-aut-name=松浦徹 kn-aut-sei=松浦 kn-aut-mei=徹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経内科学 en-keyword=ネットワーク kn-keyword=ネットワーク en-keyword=神経難病 kn-keyword=神経難病 en-keyword=神経内科 kn-keyword=神経内科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本における性感染症患者の適切な管理に影響する因子について kn-title=Factors Affecting Appropriate Management of Patients with Sexually Transmitted Infections in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KodamaTomoe en-aut-sei=Kodama en-aut-mei=Tomoe kn-aut-name=兒玉とも江 kn-aut-sei=兒玉 kn-aut-mei=とも江 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=糖尿病性腎症患者の食事療法に影響を与える要因 kn-title=Influencing Factors for Dietary behaviors of Patients with Diabetic Nephropathy en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SumiyoshiKazuko en-aut-sei=Sumiyoshi en-aut-mei=Kazuko kn-aut-name=住吉和子 kn-aut-sei=住吉 kn-aut-mei=和子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=シンバスタチンによる特発性肺動脈性肺高血圧患者の肺動脈平滑筋細胞における血小板由来増殖因子のシグナル伝達に対する抑制効果 kn-title=Inhibitory Effects of Simvastatin on Platelet-derived Growth Factor Signaling in Pulmonary Artery Smooth Muscle Cells From Patients With Idiopathic Pulmonary Arterial Hypertension en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkedaTetsuya en-aut-sei=Ikeda en-aut-mei=Tetsuya kn-aut-name=池田哲也 kn-aut-sei=池田 kn-aut-mei=哲也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=31 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Electrcardiographic Changes in Rheumatoid Arthritis: Part 2. Frequency of Electrocardiographic Changes in Rheumatoid Arthritis and Other Diseases kn-title=慢性多発性関節リウマチ患者の心電図に就いて（第二報）"慢関リ"及び其の他の疾患群での心電図異常所見の頻度 en-subtitle= kn-subtitle= en-abstract= kn-abstract=As reported in Part 1 of this paper, the author observed a variety of electrocardiographic aberrations in 27 patients with rheumatoid arthritis. This report will compare the frequency of electrocardiographic aberrations in 45 such cases with the frequencies shown by other groups, namely : a group of 122 patients with normal blood pressure and noncardiac diseases, a group of 121 patients with hypertension, and a group of 14 patients with mitral valve diseases. The results are as follows : 1) The electrocardiographic patterns reported in Part 1 occurred more frequently in both the group of rheumatoid arthritis patients and the groups of hypertension and mitral valve disease patients than in the group with normal blood pressure and noncardiac diseases. 2) On the basis of the electrocardiographic findings, it may be assumed that many of the patients with rheumatoid arthritis suffered from pathological heart conditions, such as heart diseases or cardiac involvement, not accessible to clinical observation. 3) Patients with unequivocal cardiac involvement constituted 21 (46.6%) of the rheumatoid arthritis patients, 65 (53.7%) of the hypertension patients, 9 (64.3%) of the mitral valve didease patients, and 21 (17.2%) of the normal blood pressure and noncardiac disease patients. 4) Patients with suspected cardiac involvement, as defined in Part 1 of this paper constituted 4 (8.9%) of the rheumatoid arthritis patients, 10 (8.3%) of the hypertension patients, 1 (7.1%) of the mitral valve disease patients and 2 (1.6%) of the normal blood pressure and noncardiac disease patients. en-copyright= kn-copyright= en-aut-name=KitayamaMinoru en-aut-sei=Kitayama en-aut-mei=Minoru kn-aut-name=北山稔 kn-aut-sei=北山 kn-aut-mei=稔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所医学部門内科 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=10 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Electrcardiographic Changes in Rheumatoid Arthritis: Part 1. Relationship between Electrocardiographic and Clinical Findings kn-title=慢性多発性関節リウマチ患者の心電図所見に就いて（第一報）classical rheumatoid arthritisに属する27名の臨床像との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied the relationship between electrocardiographic and clinical findings in 27 patients with classical rheumatoid arthritis, as defined by the criteria for the diagnosis of rheumatoid arthritis proposed by the American Rheumatism Association. The results obtained were as follows: 1) In 26 of the cases, such electrocardiographic aberrations were observed as the following: broad P waves; mitral P-like patterns (either double peaked or with the mean P vector veering to the left in the frontal plane) ; prolongation of the P-Q interval; high amplitude of R in the left precordial lead; elevation or depression of S-T segments; low or flat T waves in the left precodial lead; prolongation of QTc ; and changes of directions of mean QRS and T vectors to the left in the frontal plane. 2) The frequecies of plainly pathologic findings were as follows: prolonged P-Q interval - 1 case (3.7%) ; RV5≧30mm - 3 cases (11.1%) ; elevation of S-T segment - 1 case (3.7%) ; depression of S-T segment - 3 cases (11.1%) ; and prolongation of QTc - 9 cases (33.3%). 3) Pathologic cardiac involvement was found in 13 patients (48.2% of the total group) while 3 other patients were classified as suspected cardiac involvement cases, defined as those characterized by more than three abnormal but non-pathologic findings. 4) Thus, the majority of the test group were characterized by some abnormal or pathologic electrocardiographic finddings, although clinically no heart diseases or cardiac insufficiency had been detected. en-copyright= kn-copyright= en-aut-name=KitayamaMinoru en-aut-sei=Kitayama en-aut-mei=Minoru kn-aut-name=北山稔 kn-aut-sei=北山 kn-aut-mei=稔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所医学部門内科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=29 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effect of A Single Bath in Radioactive Hot Spring Water on Variability in Electrocardiograms of Patients with Internal Diseases　(1) Repeat Variability in Electrocardiograms of the 100 Patients without Bathing kn-title=三朝温泉の入浴が諸種内科疾患患者の心電図に及ぼす影響（第一報）非入浴時の心電図の変化に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The authors studied time-to-time variability of 100 patients with internal diseases in 100 ECG's over a period of 15 minutes. The variavirity were observed on eleven electrocardiographic items which were measured in 12 leads (I～III, (a)V(R)～(a)V(F), V(1～6)). The electrocardiograms were recorded by same technician, who carefully recorded in confomity to the description on the variability due to techinical and biologocal sources in Simonson's writing and were measured by one of the authors. Frequency distribution of differences between each two electrocardiograms of the same patients are shown in Figures (from 1 to 11) and 5% rejection limits of these differences, which were calculated in use of the stochastics, were as follows : P duration (sec. ) : + 0.022 >X(0)> - 0.021 P-Q duration (sec.) : + 0.029 >X(0)> - 0.024 QRS duration (sec.) : + 0.018 > X(0)> - 0.013 R-R interval (sec.) : + 0.168 >X(0)> - 0.141 QT Ratio (%) + 10.01 >X(0)> - 7.89 QT(c) : + 0.032 >X(0)> - 0.022 P/PR segment : + 0.914 >X(0)> - 0.832 QT/TQ + 0.192 >X(0)> - 0.190 T/R V(5) : + 0.116 >X(0)> - 0.090 AQRS (front. plane) : + 13. 29°>X(0)> - 13.83° AT (front. Plane) : + 14.88°>X(0)> - 16.94° en-copyright= kn-copyright= en-aut-name=KitayamaMinoru en-aut-sei=Kitayama en-aut-mei=Minoru kn-aut-name=北山稔 kn-aut-sei=北山 kn-aut-mei=稔 aut-affil-num=1 ORCID= en-aut-name=KawadaYoshiro en-aut-sei=Kawada en-aut-mei=Yoshiro kn-aut-name=河田義郎 kn-aut-sei=河田 kn-aut-mei=義郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所医学部門内科 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所医学部門内科 END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue= article-no= start-page=55 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19750325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A report on the physically handicapped persons caused by rheumatoid arthritis in Tottori Prefecture, Japan kn-title=鳥取県における身体障害者手帳の交付を受けた慢性関節リウマチ患者の調査成績 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The physically handicapped persons caused by rheumatoid arthritis were studied in Tottori prefecture in July 1973. The following results were obtained ; 1. The hand i capped per sons of 265, who were recognized as the handicapped by the government authori ties, were observed. The prevalence rate was 4.7 to 10,000 of the population and 15 to 1, 000 of the total number of the hand i capped. 2. The prevalence rate of the handicapped to the total number of patients with rheumatoid arthritis was 15.4%. 3. On a reginal distribution, the prevalence rate of the handicapped to the regional population were calculated between from 0.20‰ to 0.77‰. The result showed that it was higher at rural than at urban districts. 4. The prevalence rate to population gradually increased with aging, especially over the fiftieth years. The prevalence rate of the number of serious handicapped (class 1+2) to the total number of handicapped was regnlarly at 40% between 30 and 60 years of age, but it increased over 70 years of age. 5. The sex ratio of fernIe to male was 3.3 : 1 on the total handicapped and 2.9 : 1 on the serious handicapped persons. On the other hand, the ratio was 5.1 : 1 on the group under 59 year s of age and 2.4 : 1 on the groupe over 60 years of age at the total handicapped. And then, the ratio was 5.0 : 1 on the younger group and 2.6 : 1 on the older group at the serious handicapped persons. en-copyright= kn-copyright= en-aut-name=KitayamaMinoru en-aut-sei=Kitayama en-aut-mei=Minoru kn-aut-name=北山稔 kn-aut-sei=北山 kn-aut-mei=稔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉医学部門 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue= article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Determination of ferritin in serum and in synovial fluids of patients with rheumatoid arthritis kn-title=慢性関節リウマチ患者の血清および関節液中のフェリチンの測定について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ferritin in sera and in synovial fluids were determined by method of immunoradiometric assay (IRMA) and of radioimmunoassay (RIA). These methods have been proved to be reproducible. The coefficient variation was 7.4 to 9.9% in IRMA and 5.6 to 8.0% in RIA. There were a good correlation between methods of IRMA and of RIA (r=0.989). The mean recovery rate of ferritin in serum was 101.2% in IRMA and 101.0% in RIA, respectively. The determination of serum ferritin revealed a 16% reduction in average after preservation at -20℃ during over 100 days. The levels of serum ferritin in healthy controls were 131.4±52.1 ng/ml in 34 males and 58.4±39.9 ng/ml in 38 females. The sex differences were statisticalIy significant (p<0.01). Ferritin levels were shown to be below 30 ng/ml (the state of iron deficiency) in 2 of 34 (5.9%) males and in 8 of 38 (21%) females of healthy controls. The levels of serum ferritin in patients with rheumatoid arthritis (RA) were 337.0±293.4ng/ml in 10 males and 181.4±329.9ng/ml in 25 females. The serum ferritin in RA was significantly higher than in healthy controls of both sexes. The levels of ferritin in synovial fluids of patients with 14 RA and with 12 osteoarthritis were 2894±3017 ng/ml and 1429±1005 ng/ml, and no differences were observed in both groups. en-copyright= kn-copyright= en-aut-name=FurunoKatsushi en-aut-sei=Furuno en-aut-mei=Katsushi kn-aut-name=古野勝志 kn-aut-sei=古野 kn-aut-mei=勝志 aut-affil-num=1 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=2 ORCID= en-aut-name=IrinoShozo en-aut-sei=Irino en-aut-mei=Shozo kn-aut-name=入野昭三 kn-aut-sei=入野 kn-aut-mei=昭三 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue= article-no= start-page=13 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of swimming training in the hot spring pool on ventilatory function in bronchial asthma kn-title=気管支噴息患者のventilatory functionにおよぼす運動浴療法の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Effect of free swimming training in the hot spring pool (30℃) on ventilatory function were observed in nine patients with intractable asthma by measuring FVC, FEV(1.0), PEFR, MMF, V(50), V(25). 1. Swimming in the hot spring pool for three months allowed the reduction of glucocorticoid used for their asthma attack. 2. Although FVC was not affected by swimming training, EEV(1.0), PEFR, MMF, V(50), V(25) which represent obstructive ventilatory function were gradually improved by swimming training. The results show that free swimming training in the hot springpool is clinically available in intractable asthma. en-copyright= kn-copyright= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=1 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=2 ORCID= en-aut-name=OkadaChiharu en-aut-sei=Okada en-aut-mei=Chiharu kn-aut-name=岡田千春 kn-aut-sei=岡田 kn-aut-mei=千春 aut-affil-num=3 ORCID= en-aut-name=NakagoJitsuo en-aut-sei=Nakago en-aut-mei=Jitsuo kn-aut-name=中郷実雄 kn-aut-sei=中郷 kn-aut-mei=実雄 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue= article-no= start-page=1 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research for carbon dioxide bathing IV, Thermal effect of artificial CO(2)-bathing kn-title=人工炭酸浴に関する研究 第4報, 人工炭酸浴の効果 en-subtitle= kn-subtitle= en-abstract=The artificial CO(2)-bath was prepared with a tablet (50g), made from sodium bicarbonate and succinic acid, putting simply in plain water bathtub of 150-200 litre at 40℃. Thermal effect was evaluated by means of thermography in healthy 8 men; temperature areas of 34.5℃ or greater were recorded in average compared to a plain bathing and to an artificial Na(2)SO(4)-NaHCO(3) one 10 minutes later. Clinical evaluation by questionnairings of 24 patients suffering mainly from lumbago and 4-extremity coldness revealed a long lasting peripheral warmth in 90% and the ease from pain in 85%. The artificial CO(2)-bathing was effective for women whose health were adversely affected by the cold in 63.6% and for general fatigue or dullness in 56.5% of 664 female volunteers whom the questionnairings were conducted to. No side effect was encountered in the survey. kn-abstract=1) 炭酸塩と,コ-ク酸からなる錠剤型の｢炭酸ガス浴剤｣の保温作用を健康な男子8名について,サ-モグラフィーを用いて測定した. 入浴10分後の比較で明らかに,炭酸ガス浴はよく温まった結果,表面温度が高くなっている. 2) 腰痛,四肢冷感,その他の患者24名での臨床評価の結果,患者の90%以上が手足が温まり,湯ざめしにくいことを認めた.また,患者の85%は痛みがやわらぐことを認めた. 3) 主婦664名を対象とした使用評価の結果,常時手足の冷感を訴える者の63.6%,身体の疲労感･だるさ56.5%に効果を認めていることがわかった. 4) 副作用は全く認められなかった. en-copyright= kn-copyright= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=1 ORCID= en-aut-name=KuboYuichiro en-aut-sei=Kubo en-aut-mei=Yuichiro kn-aut-name=久保裕一郎 kn-aut-sei=久保 kn-aut-mei=裕一郎 aut-affil-num=2 ORCID= en-aut-name=EguchiYasuteru en-aut-sei=Eguchi en-aut-mei=Yasuteru kn-aut-name=江口泰輝 kn-aut-sei=江口 kn-aut-mei=泰輝 aut-affil-num=3 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=4 ORCID= en-aut-name=KohmotoTomoji en-aut-sei=Kohmoto en-aut-mei=Tomoji kn-aut-name=河本知二 kn-aut-sei=河本 kn-aut-mei=知二 aut-affil-num=5 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=6 ORCID= en-aut-name=Komoto]unko en-aut-sei=Komoto en-aut-mei=]unko kn-aut-name=古元順子 kn-aut-sei=古元 kn-aut-mei=順子 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=花王石鹸株式会社栃木研究所 affil-num=2 en-affil= kn-affil=花王石鹸株式会社栃木研究所 affil-num=3 en-affil= kn-affil=花王石鹸株式会社栃木研究所 affil-num=4 en-affil= kn-affil=岡山大学温泉研究所リハビリテーション医学部門 affil-num=5 en-affil= kn-affil=岡山大学温泉研究所リハビリテーション医学部門 affil-num=6 en-affil= kn-affil=岡山大学温泉研究所リハビリテーション医学部門 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院リハビリテーション部 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=10 article-no= start-page=1597 end-page=1622 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19561031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Electroencephalographic Study on Various Diseases by Aird's Method. Part Ⅰ. Electroencephalography in epilepsy by Aird's method kn-title=エアード氏法による各種脳疾患の脳波に関する研究 第1編 エアード氏法による癲癇患者の脳波に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fourty and eight cases of epileptjcs were studied electroencephalographjcally by Aird's method before and after the operation and their foci were determined. The foci were compared with those of other methods and they were investigated before and after the operation. The results were as follows : (1) The focus of idiopathic epilepsy in this method was mostly in temporal region, and reached 72% of all cases (total of both sides). (2) The elctroencephalographic focus was on the same side of the focus determined by provocation of the convulsion to 66.6% in idiopathic epilepsy and 88.8% in symptomatic epilepsy. (3) The side of electroencephalographic focus was on the same side of the focus determined by adversive movement to 72.7% in idiopathic epilepsy and 57.1% in symptomatic epilepsy. (4) The side of the electroencephalographic focus was on the same side of the focus determined by pneumoencephalography to 92.6% in idiopathic epilepsy and to 100% in symptomatic epilepsy. (5) The side of the electroenccphalographic focus was on the same side of the determined focus to 87.8% in idiopathic epilepsy to 100% in symptomatic epilepsy and totally 92.9%, (6) The side of the presumed focus by each examination was on the same side of the synthetically determined focus in the order of eleclroencephalography (92.9%), pneumoencephalography (86.5%), initial side of provocated convulsion (72.2%), adversive movement (57.1%). The order was evaluated to be similar in idiopathic as well as symptomatic epilepsy, but generally the grade of their coincidency was higher than symptomatic epilepsy. (7) The epileptics, who showed a displacement, of focus to the frontal lobe after operation, took a good course and the convulsion decreased or dispersed. On the contrary, those, in whom no traveling of the focus or the into the motor area of the same side was seen, usually took an unfavourable course of the convulsive seizure. (8) Most of the symptomatic epilepsy showed no focus in the electroencephalogram after the operation, and accordingly no more convulsion. (9) This method is able to be a good indicator for determination of epileptic focus and judgement of the effect of therapy. en-copyright= kn-copyright= en-aut-name=InagakiTakashi en-aut-sei=Inagaki en-aut-mei=Takashi kn-aut-name=稲垣節 kn-aut-sei=稲垣 kn-aut-mei=節 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=42 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Atopic asthma in patients of middle or advanced age kn-title=中高年令者のアトピー型喘息について en-subtitle= kn-subtitle= en-abstract=In order to elucidate the characteristics of atopic asthma in patients of middle or advanced age (over 41 years old), 88 atopic asthmatic patients were divided into 4 groups according to their ages, 0～20, 21～40, 41～60 and over 61 years old, and age, sex, age of onset, past history, family history, number of peripheral eosinophils, serum IgE and skin test were compared among these groups. The results were as follows: Atopic ashmatic patients of middle or advanced age were 1) less frequent in all asthmatic patients of same age group, 2) more frequent in males than in females, 3) higher in averaged age of onset, 4) more frequent in cases without other allergic past histories, 5) less frequently positive to house dust and more frequently positive to Candida and Aspergillus in skin test, 6) not different in family history, number of peripheral eosinophils and serum IgE compared to other groups. kn-abstract=中高年令（41才以上）のアトピー型喘息患者の特徴を明らかにするために，アトピー型喘息患者88例を0～20才，21～40才，41～60才，61才以上の各年令別に分け，年令，性別，発症年令，既往歴，家族歴，末梢血好酸球，血清IgE値，皮内反応の各項目について検討を加えた。結果は，中高年のアトピー型喘息患者は1）その年代の全喘息患者に占める割合は低く，2）男性が多く，3）平均発症年令は高く，4）その他のアレルギー性疾患の既往歴を持たない症例が比較的多く，5）皮内反応では，ハウスダスト陽性率が比較的低く，カンジダ，アスペルギルスの陽性率は比較的高い傾向にあった。6）家族歴，末梢血好酸球，血清IgE値では，明らかな傾向は認められなかった。 en-copyright= kn-copyright= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=アトピー (Atopy) kn-keyword=アトピー (Atopy) en-keyword=中高年令者 (patients of middle or advanced age) kn-keyword=中高年令者 (patients of middle or advanced age) en-keyword=喘息 (asthma) kn-keyword=喘息 (asthma) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=31 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息および慢性気管支炎患者における抗ヒトIgEによる好塩基球からのヒスタミン遊離 kn-title=Basophil histamine release by anti-IgE in Subjects of chronic bronchitis and bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息50例，慢性気管支炎8例を対象に，抗ヒトIgE添加時の好塩基球からのヒスタミン遊離を全血法により行ない，その臨床的評価について検討を加えた。抗ヒトIgE海底時のMax　％　histamine releaseの平均は，健康人24.7±14.2％，慢性気管支炎27.7±22.1％，気管支喘息28.4±17.0％であり，3者間に有意の差はみられなかった。すなわち，抗ヒトIgE添加により健康人や慢性気管支炎患者の好塩基球からも有意のヒスタミン遊離が見られた。気管支喘息のなかでは，内因性喘息症例においてヒスタミン遊離（14.1±7.2％）の低い傾向が見られた。Dose-response curveの検討では，健康人，慢性気管支炎症例では全例E（2）からE（1）へかけてのnegative slopeを示した。気管支喘息症例では，血清IgE値500IU/ml以下の症例ではnegative slopeを示す症例が多く，一方501IU/ml以上の症例ではpositive slopeを示す症例がより多く見られた。 kn-abstract=Histamine release from basophils induced by anti-IgE was studied in 8 patients with chronic bronchitis and 50 patients with bronchial asthma by analyzing doseresponse curves. As the result, there were no significant differences in maximum percent histamine release from basophils among three groups of healthy subjects (24.7± 14.2%), patients with chronic bronchitis (27.7±22.1%) and those with bronchial asthma (28.4±17.0%). In the patients with bronchial asthma, the maximum percent histamine release was higher in accordance with higher serum IgE levels, and low maximum percent release was observed in patients with intrinsic asthma (14.1±7.2%). Study of dose-response curves of anti-IgE-induced histamine release showed that a negative slope from E(2) to E(1) was observed in both healthy subjects and patients with chronic bronchitis. The majority of asthmatics with serum IgE levels of 501IU/ml or over showed a positive slope from E(2) to E(1). en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=4 ORCID= en-aut-name=TsujiMitsuaki en-aut-sei=Tsuji en-aut-mei=Mitsuaki kn-aut-name=辻光朗 kn-aut-sei=辻 kn-aut-mei=光朗 aut-affil-num=5 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=6 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Basophil response (好塩基球の反応性) kn-keyword=Basophil response (好塩基球の反応性) en-keyword=Anti-lgE (抗ヒトIgE) kn-keyword=Anti-lgE (抗ヒトIgE) en-keyword=Histamine release (ヒスタミン遊離) kn-keyword=Histamine release (ヒスタミン遊離) en-keyword=chronic bronchitis (慢性気管支炎) kn-keyword=chronic bronchitis (慢性気管支炎) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=5 article-no= start-page=211 end-page=218 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The statistical observations of the out-patients and in-patients during five years since the opening of the Department of Oral Surgery, Okayama University Medical School kn-title=岡山大学医学部歯科学教室開講5ケ年間に於ける外来患者並びに入院患者の統計的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The statistic observations were made about the inpatients and out-patients of the department of oral surgery, okayama university medical school during full five years from July in 1950 to June in 1955. The out-patients were classified into those of inflammation (pulpitis and gingivitis excepted), of caries (which was divided into what needed canal treatment and what was not so serious), of pyorrhea alveolaris, of gingivitis, of tumour, and of other diseases, and then each disease group was observed according to the difference year, season, tooth, sex, age, and occupation. Thereby, comparatively remarkable, interesting, statistical, numeral values were not only obtained concerning to each disease, but also the characteristics of the department of oral surgery of the attached hospitals of our government universities were apparently recognized here also. As the total number of the in-patients was only 237, the detailed statistical report being reserved, they were observed only according to the difference of year and disease. Thereby, inflammation and tumour were so many that they occupied about 80% of the number of all the in-patients. en-copyright= kn-copyright= en-aut-name=FujiokaYukio en-aut-sei=Fujioka en-aut-mei=Yukio kn-aut-name=藤岡幸雄 kn-aut-sei=藤岡 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= en-aut-name=OnoHajime en-aut-sei=Ono en-aut-mei=Hajime kn-aut-name=小野一 kn-aut-sei=小野 kn-aut-mei=一 aut-affil-num=2 ORCID= en-aut-name=NishijimaKatsumi en-aut-sei=Nishijima en-aut-mei=Katsumi kn-aut-name=西嶋克巳 kn-aut-sei=西嶋 kn-aut-mei=克巳 aut-affil-num=3 ORCID= en-aut-name=KagawaGaiji en-aut-sei=Kagawa en-aut-mei=Gaiji kn-aut-name=香川凱二 kn-aut-sei=香川 kn-aut-mei=凱二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部歯科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部歯科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部歯科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部歯科学教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1-4 article-no= start-page=142 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=1956 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=我が教室に於ける歯槽膿漏症に関する研究 歯槽膿漏症患者の歯肉嚢内滲出液の形態学的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=薗田芳澄 kn-aut-sei=薗田 kn-aut-mei=芳澄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1-4 article-no= start-page=139 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=1956 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=我が教室に於ける歯槽膿漏症に関する研究 齒槽膿漏症患者の切除齒肉に於けるヒスタミン量について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤岡幸雄 kn-aut-sei=藤岡 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1-4 article-no= start-page=126 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=1956 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=我が教室に於ける歯槽膿漏症に関する研究 齒槽膿漏症患者の血糖について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=薗田芳澄 kn-aut-sei=薗田 kn-aut-mei=芳澄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1-4 article-no= start-page=121 end-page=122 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=1956 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=我が教室に於ける歯槽膿漏症に関する研究 齒槽膿漏症患者の赤血球沈降反応について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤岡幸雄 kn-aut-sei=藤岡 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1-4 article-no= start-page=119 end-page=121 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=1956 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=我が教室に於ける歯槽膿漏症に関する研究 齒槽膿漏症患者の血液所見に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平井茂喜 kn-aut-sei=平井 kn-aut-mei=茂喜 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=12 article-no= start-page=4603 end-page=4612 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=1958 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Capillary Picture at the Root of the Nail in Infectious Hepatitis Part 3 Studies on the capillary picture at the root of the nail in infectious hepatitis on the mass medical examination kn-title=流行性肝炎患者の指爪根部毛細血管像に関する研究 第三編 集団検診時における流行性肝炎患者の指爪根部毛細血管像の観察 en-subtitle= kn-subtitle= en-abstract=The capillary picture at the root of the nail, on the exposed patients by the mass medical examination at the 6 districts of Okayama prefecture in where the mass occurence of infectious hepatitis were seen, were observed. The results are as follows. 1. At the district with many severe hepatitis, the form of capillary picture is simlar to the typical feature in hospital cases, at the district with many mild hepatitis it is similar to the feature in health, except a little abnormality, and at the district with relatively many mild hepatitis it is similar to the finding between the feature in healthy and hospital cases. 2. The slight dilatation of the arteriovenous limb in width, the slight contraction of the capillary loop in width and the extension of the loop length in some, but not in some, are observed on the exposed patients in those districts. But these findings are considerably stirred by the situation of epidemic mass occurence and their symptoms. 3. The delay in the rate of blood flow, the formation of granules and the incomplete continuation and intermittence of blood flow etc. are generally observed, but there are considerable differences in each epidemic district. However, the findings at the district with severe hepatitis is similar to the typical feature. 4. As compared with it in health, the capillary reaction judged summarily from the above findings of the exposed cases on the mass medical examination are abnormal in most cases of each group, especially at the districts with typical or severe hepatitis. 5. The typical capillary reaction is not invariably observed on the mass medical examination, especially on the mild form, as well as the capillary picture of the hepatitis cases observed with the progress, but the capillary reaction is still a useful finding for the diagnosis of infections hepatitis. 6. The relation between the capillary reaction and the clinical findings, blood picture, urobilinoge reaction in urine, various serum colloidal reactions, hepatomegaly and splenomegary etc. is observed, but no correlation between them is necessarily found on the mass examination's cases because there may be involving various complicated factors in the stage, course and symptom of disease. 7. The capillary picture of the 50 exposed cases as the latent and incomplete mild ases, which can not be definitely diagnosed as infectious hepatitis, but which are in denger being exposed as same as the patient and have the complaints of indistinct gastroentero-flue-symptoms, fatigue and general strange feeling etc. by which any diagnosis, other than hepatitis, can not be made, aend which show a typical picture on the hematological examination, are found on theit capillary picture. The cases with a definie abnormal capillary pictuere have the complaints of headache, general weariness and exhaustion etc, and 10 of them fall ill later on the occasion of overwork. 8. The theory of Prof. K. Yamaoka, which the general reaction as a primary change of infectious hepatitis is occured to center around the blood vesseles reaction, is supported with the above results. And the capillary picture also can be proved as a method to expose latent or incomplete mild caess of infectious hepatitis. kn-abstract= en-copyright= kn-copyright= en-aut-name=YoriyaTsuneo en-aut-sei=Yoriya en-aut-mei=Tsuneo kn-aut-name=庵谷恒夫 kn-aut-sei=庵谷 kn-aut-mei=恒夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=12 article-no= start-page=4593 end-page=4602 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Capillary Picture at the Root of the Nail in Ifeectious Hepatitis Part 2 Studies on the correlativity between the capillary picture at the root of the nail and the results of the clinical examinations kn-title=流行性肝炎患者の指爪根部毛細血管像に関する研究 第二編 指爪根部毛細血管像と各種臨床検査成績との相関性について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The capillary picture at the root of the nail was observed, comparing it with the results of the various clinical examinations, on 60 cases of hepatitis in our hospital and the correlativity between them was studies. The results are as follows. 1. The correlation between hepatomegaly and the capillary reaction is observed. 2. The correlation between splenomegaly or enlargement of the splenic dulness and the capillary reaction is observed. 3. The severe capillary reaction is observed in the cases with the decrease of hemoglobin in volume and erythrocyte in number, and also in the cases with the decrease of leucocyte in number and the remarkable increase of monocvte. 4. The correlation between the capillary reaction and the liver functions, i.d. urobilinogen and bilirubin in urine, bilirubin in serum jaundice and also the serum colloidal reaction, excretory process of foreign bodies antidotal function. The severe capillary reaction is also observed in the cases with the decreased ratio of albumin/globulin. 5. The special correlation between the sedimentation rate and the capillary reaction is not observed. 6. The correlation between the hemorrhagic tendency and the capillary reaction is not observed, but the correlation is observed in the cases with a hemorrhage on the capillary picture. 7. The opposite attitude is observed between the cases with the star-form capillary dilatation in the body surface and the capillary reaction at the root of the nail. 8. The capillary reaction has relation to the biopsy findings of the liver, especially the parenchymal damage of the liver, but no relation to the change of the Glisson's capsule. However, no differences of the capillary reaction are observed between the cases with the parenchymal and stromal change. 9. The disorder of the autonomic nervous system is greatly observed in the cases of chronic hepatitis with the normal liver function, but with the capillary reaction. 10. The capillary picture at the root of the nail is expected to achieve the important roles on making the diagnosis, observing the course and judging the prognosis of hepatitis, since it finely agrees with the results of the various clinical examinations. en-copyright= kn-copyright= en-aut-name=YoriyaTsuneo en-aut-sei=Yoriya en-aut-mei=Tsuneo kn-aut-name=庵谷恒夫 kn-aut-sei=庵谷 kn-aut-mei=恒夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=12 article-no= start-page=4585 end-page=4592 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Capilary Picture at the Root of the Nail in Infectious Hepatitis Part 1 Studies on the Capillary Picture in Acute and Chronic Hepatitis kn-title=流行性肝炎患者の指爪根部毛細血管像に関する研究 第一編 急性竝に慢性型の毛細血管像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The capillary picture at the root of the nail was observed on 608 cases of epidemic hepatitis in connection with the results of their clinical findings, and was compared with the capillary picture at the root of the nail in health. The results are as follows. 1. In the cases being able to examine in the prodromal stage, the Ⅱ to Ⅴ form on morphological classification are greatly observed and the pathologic findings, the increase in the length and width of the capillary loop, the decrease in the number of capillary, the delay in the rate of blood flow, the formation of granules and the incomplete continuation and intermittence of blood flow etc, being accompanied with an indefinite findings on the cases with the severe pathologic change, are observed in some cases. 2. The most remarkable findings in the early stage to the predominant stage of hepatitis are edema and collapse-bleeding in the capillary loop, and the various changes observed in the prodromal stage are more reinforced in this stage. 3. The various capillary changes in the predominant stage are decreased in proportion to the course of disease, i.e. the convalescent stage and postponement or chronic stage. 4. The changes of the capillary picture at the root of the nail in epidemic hepatitis are also clarified being observed on the capillary of the various organ in the body, comparing the results of the above studies with the histological observations of the starform capillary dilatation on the surface of the living body, of the capillary picture of the various organs in the cadavers of hepatitis patients and also the pathohistological studies of their tissues. en-copyright= kn-copyright= en-aut-name=YoriyaTsuneo en-aut-sei=Yoriya en-aut-mei=Tsuneo kn-aut-name=庵谷恒夫 kn-aut-sei=庵谷 kn-aut-mei=恒夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=10 article-no= start-page=3889 end-page=3903 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Leucocyte Function in Pulmonary Tuberculosis Part 3. The Effect of Thoraco-Surgical Treatment on the Leucocyte Function in Pulmonary Tuberculosis kn-title=肺結核患者の白血球機能に関する研究 第三編 肺結核患者の白血球機能に及ぼす胸部外科手術の影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to see the effects of thoraco-surgical treatment on leucocyte function in pulmonary tuberculosis, the author examined the picture, wandering velocity, and phagocytesis of leucocytes in the patients with pulmonary tuberculosis, starting before operation and continued for three months; and obtained the following results; Pulmonary Resection 1. The total leucocyte count: The effect of surgical treatment is most marked on the day of operation, namely the leucocyte count increases up to 10,000-20,000, but rapidly decreasing thereafter, it returns to the pre-operation level by the 20th day and it keeps its normal level thereon. And the increase or decrease in the leucocyte count more or less parallels with the extent of operation and the increase or decrease in the neutrophil count. 2. Fluctuations of various leucocytes: The change in the neutrophil count takes about the same course as that of the leucocyte total. The eosinophil count begins to disappear immediately after operation and appear on the third day; thereafter, it returns to the pre-opsration level. As for the basophil count, with the exception of a transient increase on the third day, it shows no fixed trend neither monocytes. As for the percentage of lymphocytes, a marked decrease can be observed on the day of operation, and thereafter, recovering gradually, it takes somewhat the opposite course to that taken by neutrophils, but the absolute count shows no marked change. 3. The leucocyte function: The wandering velocity of leucocytes is accelerated on the day of operation, and declining thereafter, shows its minimum on the third day after operation, but by the 10th day it returns to the preoperation level, thereon it surpasses that level. The phagocytosis of leucocytes is promoted on the day of operation, and falling down to its minimum on the second day after operation, it returns to the preoperation level on the fifth day, and later it surpasses that level. Namely, on the day of operation leucocytes show what Sugiyama calls "progressive left-shift of the nucleus", and the second day as the turning point their picture is transferred to "regressive left-shift of the nucleus", and it returns to that before operation on the 5th to 10th day. Thereafter the leucocyte function is accelerated, and also it is obvious that the phagocytosis of leucocytes is more responsive to reaction than the wandering velocity Thoracoplasty Leucocyte findings and their function by this treatment show rather similar tendency observed in the Pulmonary resection. The improvement up to the 20th day after the treatment in this case, however, is relatively more rapid than that in the Pulmonary resection, while after one month the improvement is a little inferior to that by the former method. Group Showing Postoperative Complication About the 5th day after operation the decrease in the leucocyte count of this group is less than that of the group with good postoperative improvement, and also the recovery of the leucocyte function is slower, showing no return to the preoperation level. Summarizing the above, the thoraco-surgical treatment essentailly acts as a stress on patient, and the response to the operation appearing most markedly on the day of operation, the direct influence of operation disappears by the 20th day. Moreover, the group with postoperative complication the recovery of leucocyte findings and their function is prolonged. It is believed that the follow-up examinations of the leucocytes and the leucocyte function offer some important clues for the determination of postoperative conditions. en-copyright= kn-copyright= en-aut-name=HaraMasao en-aut-sei=Hara en-aut-mei=Masao kn-aut-name=原正夫 kn-aut-sei=原 kn-aut-mei=正夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=10 article-no= start-page=3879 end-page=3888 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=1958 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Leucocyte Function in Pulmonary Tuberculosis Part 2. The Effects of Combination Therapy of Various Medicaments on the Leucocyte Function in Pulmonary Tuberculosis kn-title=肺結核患者の白血球機能に関する研究 第二編 肺結核患者の白血球機能に及ぼす各種薬剤併用療法の影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the successive administration of combination of such drugs as SM-PAS, PAS-INH, SM-PAS-INH, and PZA-INH to 23 patients with pulmonary tuberculosis, the author investigated the effects of these combination therapies on the leucocyte count and on the neutrophil function in the course of treatment, and obtained the following results: 1. Leucocyte count: The leucocyte count decreases up to the 5 th clay in the case of SM-PAS-INH combination; up to the 10 th day in the SM-PAS or PZA-INH combination; and up to the 20 th day in the PAS-INH combination, and thereafter it gradually increases in everyone of these combinations, until finally losing the effectiveness of the combination drug therapy by the end of one-month treatment. There on the leucocyte count is controlled by the conditions of disease. 2. Various Icucocytes: In every combination neutrophils decrease up to the 5 th-20 th day; monocytes up to the 10 th-20 th day; and lymphocytes up to the 5 th-10 th day, but in eosinophils only an increase has been observed, After one month various leucocytes change in number according to the changes in the condition of disease itself rather than to the effect of drugs. 3. Leucocyte function: The influence of each combination therapy appears most effectively between the 10 th and 20 th days; and in the combinations of Styl-PAS and PAS-INH marked acceleration of the function is brough about; while the combinations of SM-PAS-INH and PZA-INH acts inhibitorily on the function. One month after the initiation of the combination treatment and thereafter the function is influenced secondarily by changes in the conditions of a patient due to drugs administered rather than by the effect of drugs itself. 4. In other words, admitting marked clinical effects of the combination thbrapy of anti-tuberculous agents, it is important to bear in mind a possibility of some unfavorable effects of the combination therapy on the leucocyte function. en-copyright= kn-copyright= en-aut-name=HaraMasao en-aut-sei=Hara en-aut-mei=Masao kn-aut-name=原正夫 kn-aut-sei=原 kn-aut-mei=正夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=10 article-no= start-page=3869 end-page=3878 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Leucocyte Function in Pulmonary Tuberculosis Part 1. The Leucocyte Function and Conditions of Disease in Pulmonary Tuberculosis kn-title=肺結核患者の白血球機能に関する研究 第一編 肺結核患者の白血球機能と病状に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=After the general examination of blood and examinations of the leucocyte function and the pattern of their movement in 48 patients with pulmonary tuberculosis, the author studied the relationship between the results of examinations and conditions of disease; and obtained the following results: 1. The leucocyte count inceases along with aggravation of disease; and there can be observed a marked increase of lymphocytes in minimal cases; of monocytes, neutrophils and lymphocytes in moderately advanced cases; and of monocytes and neutrophils in far advanced cases. In other words, the increase in monocytes and neutrophils becomes marked as tuberculosis advances in severity. On the other hand, the percentage of lymphocytes indicates the advance of tuberculosis. Moreover, the farther advanced the disease, the more marked is the tendency of the left-shift of the nucleus in neutrophils, and also the ratio L: M decreases accordingly. Although a decrease in eosinophils can generally be observed, there is no di stinct correlation between this decrease and the condition of disease. 2. Leucocyte function: The leucocyte function in minimal cases generally is about the same as that of the normal persons, but as the disease advances to moderately advanced and to far advanced stages, it decreases along with the advance. The leucocyte function declines in proportion to the increase in erythrocyte sedimentaion rate, and those with over 25 mm erythrocyte sedimentation rate show a marked decline in the function. According to Oka's classification based on X-ray findings, the function in Type Ⅶ is markedly lower than that in Types Ⅵ, Ⅳ and Ⅴ. And according to the NTA classification as the extensiveness of lesions advances from the minimal to moderately advanced and far advanced, or according to the clinical classification as the inactive type moves to the arrest and to the active typse, the leucocyte function proportionately decreases more and more markedly. Relative to number of tuberculous bacilli, in those who are negative to bacillus culture the leucocyte function does not differ much from that of the normal, but as the culture, bacillus collection and smear specimens turn to positive, the leucocyte function gradually declines. As for the relationship with the body temperature and pulses, along with the rise in body temperature and increase in pulse-beats the leucocyte function diminishes, especially the decline is quite marked in the case with the body temperature of over 38℃ and pulses over 100. Moreover, in the case when the leucocyte count increases, the leucocyte function is enhanced up to the count of 8,000, but beyond 10,000 the function is extremely diminis hed. The greater the average number of nuclei, the greater in the acceleration of leucocyte function, and in those whose L/M ratio is 16-23, the leucocyte function is highest. Of those patients with pulmonary tuberculosis of moderately advanced stage or far advanced showing an increase in leucocyte count, a decrease in the average nucleus count, and a low L/M ratio; the ones with accelerated leucocyte function later improve, while ones with lowered leucocyte function still get worse and worse. 3. Movement pattern of leucocytes in pulmonary tuberculosis: As the disease aggravates, Types A(3), B(2), and D with low wandering velocity increase in number. In addition, even in those with the same movement pattern, as the disease aggravates, the wandering velocity decreases that much more. en-copyright= kn-copyright= en-aut-name=HaraMasao en-aut-sei=Hara en-aut-mei=Masao kn-aut-name=原正夫 kn-aut-sei=原 kn-aut-mei=正夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=9 article-no= start-page=3381 end-page=3391 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serum Protein in Alkylphosphate Poisoning Part Ⅰ. Serum Protein in Patients with Parathion Poisoning kn-title=有機燐製剤中毒と血清蛋白 第一編 パラチオン中毒患者の血清蛋白像 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the aid of electrophoresis the author pursued serum protein in fifteen patients stricken with parathion poisoning that broke out in the summer from 1955 to 1957; and obtained the following results: 1. As for the pathological changes common to all an increase in serum total protein could be observed at the onset and this increase was mainly due to an increase in the albumin fraction. Consequently the A/G ratio is also increased. The severer the parathion poisoning the more marked is the increrase, suggesting that in all probability a stimulation of the parasympathetic nervous system by poisoning is responsible for it. 2. The decrease in the serum total protein, albumin fraction and A/G ratio 2-3 days after the onset seems to be due to the paralysis of the parasymathetic nervous system by a large dosage dosage of atropine administration. In contrast to this, PAM (pyridine-2-aldoxime methiodide), without inducing change in the serum protein but improving symptoms of poisoning, namely, restoring the balance of the autonomous nerves, brings the protein picture back to normal. en-copyright= kn-copyright= en-aut-name=KurodaYuichi en-aut-sei=Kuroda en-aut-mei=Yuichi kn-aut-name=黒田祐一 kn-aut-sei=黒田 kn-aut-mei=祐一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=8 article-no= start-page=3041 end-page=3051 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The P.H. and Proteins in the Saliva of Patients with Cervical Carcinoma kn-title=子宮頸癌患者の唾液P.H.及び蛋白質に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=As the auxiliary diagnosis for carcinoma of the cervix the author evaluated the pH, whole proteins. and protein fractions in the saliva; and obtained the following results: 1) The pH of the saliva in patients with cervical carcinoma is lower than that in the case of normal non-pregnant women, and it becomes more marked with the lapse of time. In 25.6 per cent of the patients in Stage Ⅰ an abnormally low pH of under 6.2 can be observed, showing a significant difference as compared with the normal non-pregnant women; but as the percentage is low, it can not be so useful for an early diagnosis. 2) In 9.6 per cent of those whose improvement is good at follow-up examinations after treatment such an abnormally low pH can be found, and in them pH returns to the normal level only after one year. In 33.3 per cent of those whose prognosis is poor, an abnormally low pH value can be recognized. In the follow-up examinations successively abnormally low pH can be found in 8.0 per cent of those with a good improvement, and in 66.6 per cent of those with a poor improvement. Sixty per cent of those showing abnormally low pH successively are those with a poor prognosis. 3) The amount of whole protein in the saliva of patient with cervical carcinoma shows a slight increase over 46.2 mg/dl in the case of normal non-pregnant women. Statistically a significant difference at 79.0 mg/dl can only be recognized in those at Stage Ⅳ. As for the percentage of those showing as abnormally high as 72.26 mg/dl, 28.9 per cent of those in Stage Ⅱ show abnormally high value as compared with normal non-pregnant women, but it has little value for diagnosis. 4) An increase in whole protein can be recognized in the anemic patient showing sahli value of under 59 per cent. 5) No significant difference can be recognized in the protein fractions of the saliva in the patients with cervical carcinoma as compared with normal non-pregnant women. From these data it is assumed that the evaluations of the whole protein content and protein fractions in the saliva are not so useful as an auxiliary diagnosis of cervical carcinoma, but the continuous follow-up estimations of pH of the saliva for the purpose of discovering the recurrence of cervical carcinoma at an early stage enable us to foresee it, and such follow-up examinations will offer us an important criterion for the judging of the conditions after treatment. en-copyright= kn-copyright= en-aut-name=KawadaKenji en-aut-sei=Kawada en-aut-mei=Kenji kn-aut-name=河田謙二 kn-aut-sei=河田 kn-aut-mei=謙二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=7 article-no= start-page=2517 end-page=2524 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Eosinophils in the Bone-Marrow Tissue Culture Part 2. Observation on the Motility of Eosinophils in the Bone-Marrow Tissue Culture of the Sternum of various Patients with Eosinophilia kn-title=骨髓体外組織培養による好酸球に関する研究 第2編 各種好酸球増多症患者の胸骨骨髓培養における好酸球運動の観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By performing bone-marrow tissue culture (simple method devised in our laboratory) of the sternum in normal person, patients wish anchylostomiasis and with bronchial asthma, the author observed the pattern of movement and wandering velocity of these eosinophils and obtained the following results: 1. Patterns of movement of eosinophils in the human bone marrow have been newly classified. 2. Among the eosinophils of human anchylostomiasis there are ones that show a peculiar pattern of movement, Type IB, which may be considered to be the acceleration in the ability of retraction of the exoplasm. In addition, a picture of scattered granules can often be recognized. The wandering velocity of eosinophils in this disease is markedly accelerated, showing the veloeity somewhat superior to that of neutrophils. 3. In the eosinophils of bronchial asthma there are cells suggesting an abnormally accelerated adhesive property, for example, possessing abnormally distended tail or filamentous tail with many branches; and also granule-movement is quite active. As can be seen from the above findings, there are eosinophils in anchylostomiasis and bronchial asthma, that show the pattern of movement that can not be observed in those of normal persons, and therefore, it has been clarified that those eosinophils of the bone marrow in patient not only multiply in number but also their pattern of movement undergoes morphological changes simultaneously. en-copyright= kn-copyright= en-aut-name=InoueMasakatsu en-aut-sei=Inoue en-aut-mei=Masakatsu kn-aut-name=井上正勝 kn-aut-sei=井上 kn-aut-mei=正勝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=5 article-no= start-page=1725 end-page=1736 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Active Estrogen in the Urine of Uterine Cancer Patient kn-title=子宮癌患者の尿中活性Estrogenに就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=For a quite long time a considerable attention has been focused on the relationship between the etiology of cancer and estrogen, and experimental and clinical studies have been conducted from various angles. However, studies on this problem by a direct quantitative analysis of estrogen are still meager. The methods of quantitative analysis of estrogen, on the other hand, namely, both the biological and the chemical determinations, have recently been so improved that it is now possible to conduct microdetection of estrogen. Moreover, by chemical determination estrogne can now be estimated so that the actual estrogen metabolism in vivo is being clarified. Therefore, an attempt has been made to explore the relationship between cancer and estrogen. First women over three years past menopause were selected so as to avoid the effect of variations in menstrual period as well as the effect of fluctuations in estrogen at menopause. Active estrogen in urine was then determined in order to estimate indirectly the active estrogen in vivo. These procedures were undertaken for both the non-cancer and the cancer cases for the comparison: and at the same time the active estrogen in cases with cervical cancer were studied in detail by dividing the duration of cancer progress into various stages. The purpose of this paper is to present the findings obtained from the foregoing study. 1) As for the sensitivity of the biological microdetection method devised by us and applied in experimental animals that proved to be over 60 per cent positive, it has been possible to detect 0.00075 γ estradiol. Moreover, in the application of this method for comparative study of estrogen excreted into urine, it has been found that the use of urine during 12 hours at night is simpler and more adequate. 2) As for the average estrogen quantity, cases with uterine cancer tend to show an increase as compared with that in non-cancer cases; in comparing solely the cases with cervical cancer the quantity likewise tends to show an increase in contrast with non-cancer cases; and in the cases with cervical cancer at various progressive stages it has been observed that the further advanced the cancer the greater tends to be the estrogen excreted in urine. 3) Among the patients with cervical cancer, only 17.6 per cent showed a marked abnormality in estrogen as compared with non-cancer cases; and the majority of them showed estrogen distribution within the range of that in non-cancer cases. 4) Excepting these abnormally increased cases, and designating those that clearly surpassed the average of estrogen content over the control (non-cancer group) as a relatively increased group, the rate of incidence of this relatively-increased group is higher in the cases with cervical cancer than that in the control; and the rate of such incidence is higher in a more advanced case. 5) However, even in the cases of cervical cancers in stage Ⅱ and stage Ⅲ, there were some cases showing about the same proportion of relatively low quantity of estrogen as in the control; and these results rather coincided accidentally with those of disturbances observable in the liver function in the cervical cancer as already reported in the literature. In addition, in a single case in which the quantity of estrogen has been possible to compare with histological findings of ovarian lesions, as no appreciable decrease in estrogen quantity can be observed in comparison with the findings of ovarian lesions, it is assumed that the causative factor for estrogen increment exists outside the ovarian lesions. As for the causative factor the functions of the liver and of the adrenal cortex seem to play important role. However, as can be assumed from the results of experiments so far described, the disturbances in the liver functions appear to play a principal role in elevating the quantity of active estrogen in urine of cervical cancer patient. 6) As regards the relationship between the pattern of cancer growth and the size of visible part of carcinogenic focus on one hand and the quantity of estrogen on the other, there is nothing especially noteworthy to mention. en-copyright= kn-copyright= en-aut-name=MoriKumehiko en-aut-sei=Mori en-aut-mei=Kumehiko kn-aut-name=森久米彦 kn-aut-sei=森 kn-aut-mei=久米彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産婦人科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=5 article-no= start-page=1665 end-page=1675 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Serum Polysaccharide in Pulmonary Tuberculosis Part Ⅰ. Study on the Serum Polysaccharide in Patients with Pulmonary Tuberculosis kn-title=肺結核症の血清多糖類に関する研究 第1篇 肺結核患者の血清多糖類について en-subtitle= kn-subtitle= en-abstract= kn-abstract=With Shetlar's method the author conducted determination of polysaccharide in serum of 68 patients with pulmonary tuberculosis. As for the control ten normal persons were selected; and the pulmonary tuberculous patients were consisted of 23 of minimal cases; 20 of moderately advanced cases; and 25 of far advanced cases. In addition, by studying the relationship between the blood sedimentatation rate and the results of liver function, the author arrived at the following conclusions: 1) Serum polysaccharide in pulmonary tuberculosis has been greater than that in normal persons. 2) In the patients with pulmonary tubercnlosis the amount of serum polysaccharide has increased in accordance with the widening of the tuberculous focus and the enlargement of the cavity, which seems to be a useful criterion for the determination of the stage of pulmonary tuberculosis. 3) The serum total protein in the patients is greater than that in the normal, and there is a parallel relationship between the serum total protein and serum polysaccharide. 4) In the pulmonary tuberculosis with complication of empyema the ratio of non-glucosamine polysaccharide to serum total protein (N.G.P./S.T.P.) is markedly increased, showing over a. 2.0% increase in the entire group. 5) In the patients with pulmonary tuberculosis a certain degree of parallel rerationship can be recognized between the blood sedimentation rate and N.G.P./S.T.P. 6) No intimate relationship can be recognized between the liver function and serum polysaccharide in the pulmonary tuberculosis. en-copyright= kn-copyright= en-aut-name=IwabuchiMasayoshi en-aut-sei=Iwabuchi en-aut-mei=Masayoshi kn-aut-name=岩淵正賢 kn-aut-sei=岩淵 kn-aut-mei=正賢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=3 article-no= start-page=999 end-page=1005 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Citric Acid Concentrations of the Somatic Fluid in Mental Diseases 1. Citric Acid Concentrations of Sera and Cerebrospinal Fluids in Mental Diseases and in Normal Persons kn-title=精神疾患者体液くえん酸量 第1編 正常および各種精神疾患者の血清ならびに髄液くえん酸量 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Citric acid conecnetrations in sera and cerebrospinal fluids of various psychotic patients and of normal persons were determined by Natelson's method; and the following results were obtained. Citric acid concentrations in serum: In comparing the citric acid concentrations in sera of various types of schizophrenic patients with that in serum of normal persons, it has been found that in hebephrenic form it is lower than in the normal, while in catatonic form it ranges widely from higher to lower, and in paranoid form it is nearly the same as that in the normal. In depressive form it tends to be lower than that in the normal. A marked decrease in the concentration has been observed both in chronic and deteriorated schizophrenia as well as in stupor, whereas a marked increase can be recognized in excited state. Citric acid concentration in cerebrospinal fluid: Citric acid concentration in cerebrospinal fluid has been found to be 2 or 3 times that in serum; and the value in the cerebrospinal fluid of lumbar region is greater than that in cerbral region. The concentration in the cases such as cerebrovascular disease and postlobotomy cases show an increase, whereas in hydroce-phalus it is slightly lower. en-copyright= kn-copyright= en-aut-name=OgawaTetsuro en-aut-sei=Ogawa en-aut-mei=Tetsuro kn-aut-name=小川哲郎 kn-aut-sei=小川 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=3 article-no= start-page=871 end-page=878 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Serum Bilirubin of the Lungtuberculosis Patients Part Ⅲ The influences the Administration of hemoglobin, Glucose and Others on the Metabolism of Bilirubin kn-title=肺結核患者の血清Bilirubinに関する研究 第3編 血色素や葡萄糖負荷及びその他の要件のBilirubin代謝に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=I have measured the serum bilirubin of the lungtuberculosis patients with various types. The results are as follows: (1) The total bilirubin in the healthy persons and patients having become positive to the tuberculin skin test within 6 months shows a little high level, but not efficent. (2) The total bilirubin of the lungtuberculosis patients become decreased in the severe cases and become increased in the light cases, but it's increase is not efficient. The prosperity and decay of the indirect bilirubin follows in the one of the total bilirubin, but the direct bilirubin is not observed in the most of cases and it's prosperity and decay is parallel to the one of the total bilirubin when it is observed. But it become increased in the severe cases while the total bilirubin become decreased. Because of the reverse absorption by the connection with the pathogenic changes of the liver tissue. (3) The total bilirubin become decreased in tPe gollowing cases, with active process, aggrabating symptomes, strict rest, cavity especially big cavity or maltiple cavities, remarkable body weight loosing, increased blood sedimentation rate, fever, positive bacillus in sputum, and aggravating leucocyte picture etc. (4) The total bilirubin become most decreased in the exsudative type of the mixed phthisis and the next is the productive type of it. (5) The total bilirubin of the lungtuberculosis patients with the complications especially intestinal tuberculosis shows remakably low, and it shows high in the cases with hemothorax or bloody phlegm, but it shows low in the ceses with the tendency of anemia. (6) No connections are observed between the total bilirubin and the days of illness or/and the lung function. (7) The total bilirubin is not influenced in the most of cases with the short period of various treatments, except it become decreased in the cases with the treatment of INAH and increased in the cases with the treatment of artificial pneumoperitoneum. In the cases with the longstanding administration of BAS, the total bilirubin become increased as same as the cases getting well by other treatments, but it is not changed in the cases without any changes of symptomes by the use of PAS. The direct bilirubin is not easily changed even on the cases having showed a good respondency to the treatments. (8) The prosperity and decay of the serum bilirubin is not a characteristic of the prognosis in lungtuberculosia at the present time with advanced treatments. en-copyright= kn-copyright= en-aut-name=IshikoMasaru en-aut-sei=Ishiko en-aut-mei=Masaru kn-aut-name=石河勝 kn-aut-sei=石河 kn-aut-mei=勝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=First Department of Internal Medicine, Okayama University medical School END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=3 article-no= start-page=855 end-page=870 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Serum Bilirubin of the Lungtuberculosis Patients Part Ⅱ The Connections between the Serum Bilirubin and the Liver Functions of the Lungtuberculosis Patients kn-title=肺結核患者の血清Bilirubinに関する研究 第2編 血清Bilirubinと肝機能との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=I have measured the serum bilirubin of the lungtuberculosis patients with various types. The results are as follows: (1) The total bilirubin in the healthy persons and patients having become positive to the tuberculin skin test within 6 months shows a little high level, but not efficent. (2) The total bilirubin of the lungtuberculosis patients become decreased in the severe cases and become increased in the light cases, but it's increase is not efficient. The prosperity and decay of the indirect bilirubin follows in the one of the total bilirubin, but the direct bilirubin is not observed in the most of cases and it's prosperity and decay is parallel to the one of the total bilirubin when it is observed. But it become increased in the severe cases while the total bilirubin become decreased. Because of the reverse absorption by the connection with the pathogenic changes of the liver tissue. (3) The total bilirubin become decreased in tPe gollowing cases, with active process, aggrabating symptomes, strict rest, cavity especially big cavity or maltiple cavities, remarkable body weight loosing, increased blood sedimentation rate, fever, positive bacillus in sputum, and aggravating leucocyte picture etc. (4) The total bilirubin become most decreased in the exsudative type of the mixed phthisis and the next is the productive type of it. (5) The total bilirubin of the lungtuberculosis patients with the complications especially intestinal tuberculosis shows remakably low, and it shows high in the cases with hemothorax or bloody phlegm, but it shows low in the ceses with the tendency of anemia. (6) No connections are observed between the total bilirubin and the days of illness or/and the lung function. (7) The total bilirubin is not influenced in the most of cases with the short period of various treatments, except it become decreased in the cases with the treatment of INAH and increased in the cases with the treatment of artificial pneumoperitoneum. In the cases with the longstanding administration of BAS, the total bilirubin become increased as same as the cases getting well by other treatments, but it is not changed in the cases without any changes of symptomes by the use of PAS. The direct bilirubin is not easily changed even on the cases having showed a good respondency to the treatments. (8) The prosperity and decay of the serum bilirubin is not a characteristic of the prognosis in lungtuberculosia at the present time with advanced treatments. en-copyright= kn-copyright= en-aut-name=IshikoMasaru en-aut-sei=Ishiko en-aut-mei=Masaru kn-aut-name=石河勝 kn-aut-sei=石河 kn-aut-mei=勝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=first Department of Internal Medicine, Okayama University Medical School END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=3 article-no= start-page=841 end-page=854 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Serum Bilirubin of the Lungtuberculosis Patients Part Ⅰ The connections between the Serum Bilirubin and the symptomes, processes of the lungtuberculosis patients kn-title=肺結核患者の血清Bilirubinに関する研究 第1編 血清Bilirubinと病状及び経過との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=I have measured the serum bilirubin of the lungtuberculosis patients with various types. The results are as follows: (1) The total bilirubin in the healthy persons and patients having become positive to the tuberculin skin test within 6 months shows a little high level, but not efficent. (2) The total bilirubin of the lungtuberculosis patients become decreased in the severe cases and become increased in the light cases, but it's increase is not efficient. The prosperity and decay of the indirect bilirubin follows in the one of the total bilirubin, but the direct bilirubin is not observed in the most of cases and it's prosperity and decay is parallel to the one of the total bilirubin when it is observed. But it become increased in the severe cases while the total bilirubin become decreased. Because of the reverse absorption by the connection with the pathogenic changes of the liver tissue. (3) The total bilirubin become decreased in tPe gollowing cases, with active process, aggrabating symptomes, strict rest, cavity especially big cavity or maltiple cavities, remarkable body weight loosing, increased blood sedimentation rate, fever, positive bacillus in sputum, and aggravating leucocyte picture etc. (4) The total bilirubin become most decreased in the exsudative type of the mixed phthisis and the next is the productive type of it. (5) The total bilirubin of the lungtuberculosis patients with the complications especially intestinal tuberculosis shows remakably low, and it shows high in the cases with hemothorax or bloody phlegm, but it shows low in the ceses with the tendency of anemia. (6) No connections are observed between the total bilirubin and the days of illness or/and the lung function. (7) The total bilirubin is not influenced in the most of cases with the short period of various treatments, except it become decreased in the cases with the treatment of INAH and increased in the cases with the treatment of artificial pneumoperitoneum. In the cases with the longstanding administration of BAS, the total bilirubin become increased as same as the cases getting well by other treatments, but it is not changed in the cases without any changes of symptomes by the use of PAS. The direct bilirubin is not easily changed even on the cases having showed a good respondency to the treatments. (8) The prosperity and decay of the serum bilirubin is not a characteristic of the prognosis in lungtuberculosia at the present time with advanced treatments. en-copyright= kn-copyright= en-aut-name=IshikoMasaru en-aut-sei=Ishiko en-aut-mei=Masaru kn-aut-name=石河勝 kn-aut-sei=石河 kn-aut-mei=勝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=First Department of Internal Medicine, Okayama University Medical School END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=2 article-no= start-page=573 end-page=581 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effect of Acrifuran on the Liver Function Part Ⅱ The effect of Acrifuran on the liver function of lungtuberculosis patients kn-title=肝機能に及ぼすAcrifuranの影響 第2編 肺結核患者の肝機能に及ぼすAcrifuranの影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=I havc given 20 cc of 5% Glucose with 1 mg% of 3.6-Diamino-Eurfurol 10-Methyl-Acridium Chloride intravenously to the 55 patients of lungtuberculosis once a day for 30 days. The results obtained were as follows: (1) In general, the various symptoms on the subjective symptoms were improved with this medicine especially were remarkable in benign and middle grade cases. (2) As for the effect of Acrifuran on the blood findings, they were much improved in benign cases, but they were fifty-fifty of improvement and unchangeability in middle grade cases. In severe cases, they were unchangeable or some of them showed anenicic. (3) As for the effect of Acrifuran on the liver function, all of the liver functions in benign cases were improved with Acrifuran. But the function of sugar metabolism in middle grade cases, and of bilirubin metabolism and Albumin metabolism in severe cases remained unimprovable. In general, Acrifuran gave much improvement on the Antidotal function, the function of reticuloendothelial system and of foreign body exceretion. en-copyright= kn-copyright= en-aut-name=KurataYasuo en-aut-sei=Kurata en-aut-mei=Yasuo kn-aut-name=蔵田泰郎 kn-aut-sei=蔵田 kn-aut-mei=泰郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=2 article-no= start-page=561 end-page=572 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effect of Acrifuran on the Liver Function Part Ⅰ The liver function for the patients of lungtuberculosis kn-title=肝機能に及ぼすAcrifuranの影響 第1編 肺結核患者の肝機能 en-subtitle= kn-subtitle= en-abstract= kn-abstract=I have made liver function tests for the 55 patients of lungtuberculosis and compared the results of them with the clinical findings of those patients. The results obtained were as follows: (1) Two of the liver function tests which agreed well with the clinical findings were the function of reticuloendoterial system and the function of albumin metabolism. The function of bilirubin metabolism was the next by means of the fall of serum bilirubin. (2) One of the clinical findings having the most connection with the disturbances of various liver function tests was fever. The next was the acceleration of blood sedimentation rate. The prolongation and aggravation of illness, the existence of cavity, the excretion of bacillus, the circulation spreading, the diminution of L/M ratio and the complication of intestinal tuberculosis etc. were more or less connected with the results of the liver function tests. en-copyright= kn-copyright= en-aut-name=KurataYasuo en-aut-sei=Kurata en-aut-mei=Yasuo kn-aut-name=蔵田泰郎 kn-aut-sei=蔵田 kn-aut-mei=泰郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1-3 article-no= start-page=13 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=1961 dt-pub=19610330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and Pathological Studies on the Chronicity of Viral Hepatitis 1. Follow-Up Studies on the Discharged Patients of viral Hepatitis kn-title=Virus性肝炎の慢性化に関する臨床的並びに病理組織学的研究 第1編 退院患者の遠隔成績に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Follow up studies were made on the discharged 360 cases of viral hepatitis whom needle liver biopsy had been performed during the past 6 years. (1). According to the histological picture, the cases were divided into the following groups: Acute hepatitis: Chronic hepatitis: Parenchymatous type Progressive chronic hepatitis Non-Progressive chronic hepatitis Pre-cirrhotic type Post-hepatitic cirrhosis: Cholangiolitic hepatitis: This division proved significant for prognostic study as well.(2). The mortality rate of liver cirrhosis was 11.2%. (3). Out of 219 persons who answered their clinical course after discharge, 4 was attacked by cholecystopathy; 4, by appendicitis; 3, by rheumatic arthoritis; and 4, by hemorrhoid, the total being 12.3%. (4). 3.2% of all suffered from jaundice after discharge while onefourth were susceptible to common cold and another one-fourth had gingical bleeding. (5). Only 10.9% of all were free from subjective symptom; 77.0% had fatigability; 44.7 % complained general fatigue and such disorders as headache, distended feeling of epigastrium and right hypochondriral pain followed in that order. Those symptoms were most predominant among the cases of non-progressive chronic hepatitis but were rarely found among those of acute hepatitis and parenchymatous type of chronic hepatitis. There was a tendency that the symptom disappeared gradually with recovery among acute cases while it lasted long among chronic ones. (6). Those who were subjected to precise examination showed the following results: Acute cases: 15.4% remained normal in 1-7 years after discharge. 41.6% complained subjective symptoms only. 34.8% developed into chronic. Chronic cases: 9.2% remained normal. 35.5% complained subjective symptoms only. 44.7% suffered from persistent impairment of liver function tests. Post hepatitic cirrhosis: 3.0% remained normal. 7.4% complained subjective symptoms only. 84.7% suffered from the persistent impairment of liver function tests. (7). 59.6% suffered from hepatomegaly while 12.9%, from splenomegaly. (8). Those who were examined consecutively showed a strong tendency to aggravation in each type. (9). The Stages of aggravation were clarified by the histological findings of the liver of those who were hospitalized for the second time, especially the aggravation to Laennec's cirrhosis. en-copyright= kn-copyright= en-aut-name=SeitoIchiro en-aut-sei=Seito en-aut-mei=Ichiro kn-aut-name=清藤一郎 kn-aut-sei=清藤 kn-aut-mei=一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1877 end-page=1891 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Biomicroscopic Studies on the Marginal Capillary Plexus of the Cornea Report 2 Marginal capillary plexus of the cornea of hypertensive persons kn-title=角膜輪部毛細血管に関する研究 第2報 高血圧症患者の角膜輪部毛細血管像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The marginal capillary plexus of cornea of the hypertensives was studied and the following results were obtained: 1. The width of arterial foot was 3 μ or less for 38.7% and 4-5 μ for 49.7% while it was less than 5 μ for the majority. This width was narrower than that of healthy persons. There was a tendency that the width narrowed with the age and the progress of hypertension. 2. The width of venous foot was 7 μ or less for 19.3% and 8~10 μ for 52.0% while it was less than 10 μ for the majority. This width was also narrower than that of healthy persons. There was a tendency that the width increased with the age and the rise of systolic as well as diastolic blood pressure. 3. As for the width and length of capillary loop and the direction of blood vessels, they were not much different from healthy persons and these things had nothing to do with the age and blood pressure. 4. Hemorrhage was seen though in a very few cases, and it was regarded as an in important clue to diagnosing. 5. The partial dilatations of venous foot were found in 75.0% of them. Those dilatations were fusiform or spindle-shaped, the occurrence of the former increasing with the age and the rise of systolic as well as diastolic blood pressure. It seemed that the factors of hypertension were the cause of the partial dilatations. 6. The occurrence of the intermittence and stasis of blood flow was more frequent than in healthy persons, the former affecting 39.2% and the latter, 8.2% of them. The frequency of occurrence increased with the age and the rise of systolic as well as diastolic blood pressure. 7. The speed of blood flow was slower than normal for 80.7% of them, the abnormality and its ingravescence increasing with the age and the rise of systolic blood pressure. 8. The formation of granules in blood flow was found in 56.7% of them, the percentage of granules being much higher than that of healthy persons. The frequency of occurrence rose with the age and the rise of systolic as well diastolic blood pressure. 9. The abnormality in blood volume was not characteristic in this case. 10. The comparative study of the arteries of the eye ground and the marginal capillary plexus of cornea revealed the existence of a close inter-relationship between them. 11. The effect of the cold weather on them was not much different from that on healthy persons, but it increased the width of venous foot and raised the ocurrence and ingravescence of the fusiform and spindle-shaped dilatation. en-copyright= kn-copyright= en-aut-name=SuezawaYasuko en-aut-sei=Suezawa en-aut-mei=Yasuko kn-aut-name=末沢泰子 kn-aut-sei=末沢 kn-aut-mei=泰子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=561 end-page=567 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukocyte Functions in Case of Liver Impairment Part 1. Motility and Phagocytosis of Leukocyte in Experimental Liver Impairment kn-title=肝障碍時に於ける白血球機能に関する研究 第1編 肝炎患者の白血球遊走速度並びに墨粒貪喰能に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing leukocyte motility and leukocyte phagocytosis of Indiaink on the infectious hepatitis cases, and the following results were obtained. 1. In the healthy individuals, the leukocyte motility was ranging over 22.05 to 35.71 μ/min. and 1.88 to 2.22 in the leukocyte phagocytosis of India-ink. 2. In the acute hepatitis cases, the leukocyte motility was depressed initially and was then accelated in the convalescent stadium. Leukocyte phagocytosis of India-ink showed similar tendencies although they were fairly variable in the clinical courses. 3. The both functions of leukocyte showed approximate correlations to the impairments of liver functions. 4. In the acute hepatitis cases, the both functions of leukocyte were depressed in almost parallel with fever and leukocytosis. 5. In the chronic hepatitis cases, the leukocyte motility was within normal range, however, the phagocytosis of India-ink was depressed in some cases. The leukocyte motility showed approximate correlation to the impairments of liver function, on the other hand, the phagocytosis of India-ink did not always showed such correlation. en-copyright= kn-copyright= en-aut-name=NishidaTakeshi en-aut-sei=Nishida en-aut-mei=Takeshi kn-aut-name=西田彪 kn-aut-sei=西田 kn-aut-mei=彪 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=1 article-no= start-page=53 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19591230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Oral Exfoliative Cytology in Case of Leprosy Ⅱ. Oral Exfoliative Cytology in Leprosy kn-title=癩患者における口腔剥離細胞学的研究 第2編 癩患者の口腔剥離細胞学 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In 152 in patients of the Aisei-en Leprosarium comparative studies were made on keratinization, degenerative changes, and N/C ratio with those in normal contorols. In addition, leprosy cells were proven on aspirated smear specimens taken from leproma of the face and upper extremity and their N/C ratio was compared with those of normal oral epithelial cells. 1. In leprosy keratinization was less and degenerative change of the exfoliated epithelial cells are higher than in normal. This could be proven histopathologically. 2. These changes did not show a difference between leprosy types. 3. The N/C ratio of exfoiiated epithelial cells showed no difference between normal and leprosy cases. 4. In detection of leprosy cells in aspiration the Ziehl-Neelsen method was highest in its detection percentage, which was followed by hematoxylin-eosion and Papanicolaou technics. 5. In leprosy cells the N/C ratio showed a decrease as the size of the cells showed an increase. 6. The N/C ratio showed a difference between normal epithelial cells and leprosy cells. 7. Papanicolaou technic can be considered a supplementary practical method in detection of leprosy cells in combination with Ziehl-Neelsen's method. en-copyright= kn-copyright= en-aut-name=HidakaToyozo en-aut-sei=Hidaka en-aut-mei=Toyozo kn-aut-name=日高豊蔵 kn-aut-sei=日高 kn-aut-mei=豊蔵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部歯科学教室 END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=4-7 article-no= start-page=527 end-page=539 dt-received= dt-revised= dt-accepted= dt-pub-year=1962 dt-pub=19620730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Anti-cancer Agents and Their Effects Part 2 Serum Iron Level in the Patients with the Carcinoma of the Stomach in the Combined Therapy of the Surgical Operation and the Chemotherapy kn-title=制癌剤の担癌体に及ぼす影響に関する研究 第2編 手術と化学療法との併用による胃癌患者の血清鉄の消長に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The serum iron level and the symptoms of the patients with the carcinoma of the stomach with or without Mitomycin C are studied from the Ist pre-operative day to the 25th postoperative day and compared with the normal individual, whose serum iron level is 110.6γ% in male, 109.0γ% in female and 110.0γ% of average. The serum iron level of the former is lower than the latter. In the gastrectomy cases, the serum iron level is revealed the lowest value on the 5th post-operative day and has progressively increased to the highest level being kept under the normal range until the 15 th to 20 th post-operative day, following to be on the decrease during the following 5 days; whereas the progressive decrement is observed throughout the entire pest-operative course in the cases of the explorative laparotomy. In the cases with the Mitomycin C treatment, the serum iron level is revealed as same tendency as in the gastrectomy cases and approached more closely to the normal value than that of not administered cases. The same observation is obtained in the cases with the explorative laparotomy combined with Mitomycin C treatment. The more remarkable improvement of the symptoms is noticed in the combined therapy of the surgicad operation and the Mitomycin C administration than in the surgical operation alone. It is assumed that there is a certain relationship between serum iron level and symptomes, and therefore, the determination of the serum iron level is useful for the decision of the effectiveness of anti-cancer agents. en-copyright= kn-copyright= en-aut-name=KameyamaHideyuki en-aut-sei=Kameyama en-aut-mei=Hideyuki kn-aut-name=亀山英之 kn-aut-sei=亀山 kn-aut-mei=英之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科教室 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=10 article-no= start-page=539 end-page=548 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Fgllow-up Study of Viral Hepatitis Part 1. Ten years follow-up study of infectious hepatitis in two epidemic areas kn-title=ウィルス性肝炎の予後に関する研究 第1編 流行性肝炎患者の10年後の遠隔成績について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The results of the prognostic survey were given of 79 cases of infectious hepatitis sampled in Kumayama-cho, Akaiwa-gun, Okayama Prefecture where the massive outbreak of the typical severe form occured, and of 82 cases in the Kagato area of Bizen-cho, Wake-gun, Okayama Prefecture where the mild abortive form was mostly seen during the epidemic. In the both areas the epidemics broke out 10 years prior to the author's survey. 1) In Kumayama-cho 65 cases were chosen for a set of liver function tests and the medical examination. Only 41.5% had attained the good health; 24.6% retained chronic hepatitis; 27.7% were diagnosed to be the so-called posthepatitis syndrome; and 6.2% showed hyperbilirubinemia. 2) In the Kagato area 70 cases were checked in the same manner. The results were as follows; recovery in 42.8% ; chronic hepatitis in 28.5% ; posthepatitis syndrome in 27.1% ; hyperbilirubinemia in 1.6% , 3) Nine cases in Kumayama-cho and 6 in the Kagato area were reported dead after sustaining infectious hepatitis. However, excluding a case of hepatic insufficiency, immediate cause of death were devoid of cirrhosis and hepatocarcinoma. 4) Among the 1 year, 5 years and 10 years follow-np study, a reduction of the incidence of chronic hepatitis was observed in 5 years study after the epidemics. The correlation between the incidence of chronic hepatitis and the duration of immunity to infectious hepatitis was discussed in connection with the results, 5) The female and elderly patients had a predilection for chronic hepatitis. 6) At the rate of 50.4% the patients were unaware of their illness, whereas the others had mostly complaints of general malaise and intolerance to fatty meals. Only 4% complained prolonged impaired appetite. 7) Palpable hepatomegaly was observed at the rate of 50.7% in Kumayama-cho, while 55.7% in the area of Kagato did. The incidence of hepatomegaly was reported approximately at the same rate in the acute phase of the illness. Splenomegaly subsided in size on most of the patients later in chronic phase. 8) The incidence of cirrhosis after infectious hepatitis was observed in 3.8% in Kumayama-cho and in 3.7% in the Kagato area. en-copyright= kn-copyright= en-aut-name=InoueShigeru en-aut-sei=Inoue en-aut-mei=Shigeru kn-aut-name=井上茂 kn-aut-sei=井上 kn-aut-mei=茂 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=5-6 article-no= start-page=877 end-page=885 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Hematopoetic Functions in the Bone Marrow of ihe Patients wiih Silicosis Part III. Studies on the Thrombocytopoetic Functions in the Bone Marrow kn-title=珪肺患者の骨髄造血機能に関する研究 第3編 栓球系骨髄造血機能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Investigation of the thrombocytopoetic functions of the bone marrow was performed on the clinical tissue culture of the bone marrow in the patients with silicosis to observe number and motor activity of the megakryocytes. 1) No definite differences of the number and motor ability of the megakryocytes were observed between the normal persons and silicosis patients. 2) Definite differences of the hematopotic functions in according with defferent types of the disease which were noted in the erythropoetic and leucopoetic system were not demonstrated in the thrombocytopoetic system. 3) Above findings are reasonable to presume that several factors affecting silicotic changes or secondary pathological changes following silicosis are not influenced to the thrombocytopoetic functions. en-copyright= kn-copyright= en-aut-name=NishimuraFumio en-aut-sei=Nishimura en-aut-mei=Fumio kn-aut-name=西村文夫 kn-aut-sei=西村 kn-aut-mei=文夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=5-6 article-no= start-page=865 end-page=876 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Hematopoetic Functions in the Bone Marrow of the Patients with Silicosis Part II. Studies on the Leucopoetic Functions in the Bone Marrow kn-title=珪肺患者の骨髄造血機能に関する研究 第2編 白血球系骨髄造血機能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to pursuit the leucopoetic functions in the bone marrow of the patients with silicosis, grawth ability of the cultured bone marrow and functions of the cells in the bone marrow were observed on the clinical tissue culture method of the bone marrow in the silicosis patients. Following results were obtained. 1) The growth ability of the cultured bone marrow were demonstrated within normal limits in the grawth area and cell density in the patients with chest x-ray findings of I-II and III type, while somewhat depressed in IV type. Definite depression was obrerved in C of IV type. This tendency was mostly remarkable in the findings of the cell density. 2) Functions of the bone marrow cells such as wandering velosity and phagocytic function of the india ink of the neutrophilic leucocytes were normal in I-II anb III type of the chest x-ray, and almost normal in A and B of IV type, while inhibition of the function was observed in C of IV type, en-copyright= kn-copyright= en-aut-name=NishimuraFumio en-aut-sei=Nishimura en-aut-mei=Fumio kn-aut-name=西村文夫 kn-aut-sei=西村 kn-aut-mei=文夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=5-6 article-no= start-page=851 end-page=863 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Hematopoetic Functions in the Bone Marrow of the Patients with SiIicosis. Part 1. Siudies on the Erythropoetic Functions in the Bone Marrow kn-title=珪肺患者の骨髄造血機能に関する研究 第1編 赤血球系骨髄造血機能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to observe the erythropoetic functions in the bone marrow of the patients with silicosis, roller tube culture of the sternal bone marrow and sideroblast of the silicosis patients were carried out. Following results were obtained. 1) In observation in the roller tube culture, the erythropoetic functions were revealed the most activated status in III type of the cheat x-ray findings. The grade of their activations were followed hypofunctionally by in A and B of IV type, and in C of IV type of the chest x-ray. 2) The sideroblasts were shown to be decreased in number mostly in III type of the chest x-ray and tended to decreasing in A and B in IV type, while they were increased in number in I and II and C of IV type which were shown somwhat increased than the average value of the normal healthy persons. But these latter findings ranged within normal limits. 3) Above findings are strongly suggested that the erythropoetic fnnctions are normal or slightly activated in I and II type of the chest x-ray findings and definitely acticated in III and A and B of IV type and normal or rather inhibited in C of IV type. en-copyright= kn-copyright= en-aut-name=NishimuraFumio en-aut-sei=Nishimura en-aut-mei=Fumio kn-aut-name=西村文夫 kn-aut-sei=西村 kn-aut-mei=文夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=4-6 article-no= start-page=259 end-page=266 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cytological studies on the exudates formed with the application of Usguentum Vesicans Part Ⅲ. Studies on the exudate in patients with chronic leukemia kn-title=発泡膏貼布による滲出液の細胞学的研究 第3編 慢性白血病患者の滲出液について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cellular reactions were studied through an investigation of cellular aspects of exudate formed with the application of Unguentum Vesicans to patients with chronic ieukemia.　Following are the results. 1. As compared with normal controls, some delay was noted in the onset of blister formation and numbers of cells were less, but the decrease was not so remarkable as in acute leukemia. 2. Usually, the cells consist mostly of polymorphonuclear neutrophils, and in addition a few lymphocytes, monocytes, staff neutrophils, eosinophils, and basophils were noted. In chronic myelogenous leukemia, basophils were noted in higher percentage. 3. The average numbers of nucleus segmentation of the neutrophils were about the same as in normal controls. 4. In chronic myelogenous leukemia, wandering velocity of the neutrophils was decreased as compared with normal controls, but the decrease was not so remarkable as in acute leukemia. In chronic lymphocytic leukemia, the velocity was about the same as in normal controls. 5. In chronic myelogenous leukemia, cell numbers and wandering velocity of the neutrophils were remarkably increased during remissions as compared with the pre-treatment period. en-copyright= kn-copyright= en-aut-name=SakikawaYoshinobu en-aut-sei=Sakikawa en-aut-mei=Yoshinobu kn-aut-name=咲川嘉信 kn-aut-sei=咲川 kn-aut-mei=嘉信 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=4-6 article-no= start-page=249 end-page=258 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cytological studies on the exudates formed with the application of Unguentum Vesicans Part Ⅱ. Studies on the exudate in patients with acute leukemia and monocytic leukemia kn-title=発泡膏貼布による滲出液の細胞学的研究 第2編 急性白血病並びに単球性白血病患者の滲出液について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cellular reactions were studied through an investigation of cellular aspects of exudate formed with the application of Unguentum Vesicans to patients with acute leukemia and monocytic leukemia. Followings are the results. 1. As compared with normal controls, some delay was noted in the onset of blister formation and numbers of cells were less. The decrease was especially remarkable up to 6 hours following the onset of blister formation and in some cases, acellular exudate was noted. 2. The cells consist mostly of polymorphonuclear neutrophils, and in addition a few lymphocytes, monocytes, and staff neutrophils were noted. Apperance of immature cells was noted in exceptional cases. 3. The average numbers of nucleus segmentation of the neutrophils were less as compared with normal controls. 4. Wandering velocity of the neutrophils was remarkably decreased as compared with normal controls. 5. In acute lymphocytic leukemia and monocytic leukemia, numbers of cells were increased during remissions. en-copyright= kn-copyright= en-aut-name=SakikawaYoshinobu en-aut-sei=Sakikawa en-aut-mei=Yoshinobu kn-aut-name=咲川嘉信 kn-aut-sei=咲川 kn-aut-mei=嘉信 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=5-6 article-no= start-page=425 end-page=433 dt-received= dt-revised= dt-accepted= dt-pub-year=1967 dt-pub=19670630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Delayed Type Allergy in Cancer Bearing Body Part I. Tuberculin-Allergy and its Passive Transfer in Cancer Patients kn-title=担癌生体における遅延型アレルギーの研究 第1編 癌患者のツベルクリン,アレルギーと,そのPassive transferについて en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) The tuberculin tests were given to 318 inpatients and it was found that among them the majority of cancer patients proved to be negative to the test. This fact seems to suggest that the mechanism of the delayed type allergic reaction is destroyed by cancer. 2) For the purpose of studying the delayed type allergy in cancer and non-cancer patients, the oxidation-inhibitory agent as the contactual allergy-inducing agent was smeared onto 82 patients hospitalized in our clinic. This smearing brought about a marked diminution in the allergic reaction in cancer patients. 3) When the tuberculin reaction of these cancer patients is classified according to the extent of cancer development, the negative rate to the test increases in proportion to the growt of cancer. 4) Looking at the relationship between the extent of the stomach cancer growth and the tuberculin test, it was demonstrated that the number of the patients responding negatively to the test increases along with the advance in cancer stage. 5) In our attelmpt at the pasaive transfer of 9×10(7) to 19×10(8) lymphoid cells, separated asceptically from the peritoneal lymph nodes obtained postoperatively from 15 tuberculin-positive donor non-cancer patients to 21 tuberculin-negative recipient cancer patients, it was demonstrated that 18 recipients turned positive to the tuberculin test. This result indicates that among the patients passive transfer can be accomplished with lymphoid cells isolated from lymph node. en-copyright= kn-copyright= en-aut-name=KanbaraTakeshi en-aut-sei=Kanbara en-aut-mei=Takeshi kn-aut-name=神原武志 kn-aut-sei=神原 kn-aut-mei=武志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学第一外科 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=11-12 article-no= start-page=539 end-page=547 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19701230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Treatment of Malignant Tumors with Fibroblast-inhibiting Agent Part Ⅲ. Effects of the Combined Chemotherapy with Chloroquine and Mitomycin C on Human Cancer kn-title=線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 第3編 クロロキンとマイトマイシンC併用による各種癌患者の治療に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=On the basis of our unique idea that damage of the stromal tissue might result secondarily in damage of the cancer cells, an attempt was made to administer a fibroblast-inhibiting agent, chloroquine, in combination with mitomycin C in 20 patients with malignant tumors. 1) Of the 20 cases treated, the combined chemotherapy was effective in 6, induced no significant change in 6, caused aggravation in 3, and its evaluation was impossible in 5. 2) Of various malignant tumors treated, excellent therapeutic effects were obtained in patients with pleuritis carcinomatosa.. Among subjective complaints this regimen was most efficacious in alleviating pain. 3) Side effects of chloroquine were slight and its prolonged administration was possibl. Leucopenia often associated with administration of antitumor agents was relatively rare. 4) Accordingly, the combined chemotherapy with chloroquine and mitomycin C appears to be recommendable in the treatment of human tumors from the unique chemotherapeutic point of view. en-copyright= kn-copyright= en-aut-name=MoriToshio en-aut-sei=Mori en-aut-mei=Toshio kn-aut-name=森俊雄 kn-aut-sei=森 kn-aut-mei=俊雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=9-10 article-no= start-page=411 end-page=416 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19701030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Mass Examination for Finding out Diabetics and Their Family Trees Part 3. The Disease Type and the Prognostic of Discovered Diabetics kn-title=糖尿病の集団検診と発見患者の家系調査 第3報 発見された糖尿病患者の病型と予後 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Examining for five years, mainly the change of patterns of cases who revealed positiveness on sugar, and considering the standard level by which persons are decided as diabetics, the following points were obtained as the result. 1. It is considered that adopting as the judgement level on diabetes the value more than 120 ml/dl in blood taken 2 hours after the loading is most proper for the diagnosis and adopting the value more than 100 mg/dl at hunger brings often too much high detecting rate for diabetics. 2. The classified diabetes are type Ⅲ, Ⅴ, Ⅰ and Ⅳ in the descending order of numerousness and other types were not discovered almost utterly. 3. Looking on ages, diabetics who are more than 50 ages have often the constant type diabetes being settled to type Ⅰ. 4. Type Ⅰ diabetes among the constant types diabetes can be supposed of being improved by investigating the increase and decrease to and from type Ⅰ. And the tendency of improvement was noticed in the mass of cases examined. en-copyright= kn-copyright= en-aut-name=OkumaYoshifumi en-aut-sei=Okuma en-aut-mei=Yoshifumi kn-aut-name=大隈義文 kn-aut-sei=大隈 kn-aut-mei=義文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=9-10 article-no= start-page=405 end-page=410 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19701030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Mass Examination for Finding out Diabetics and Their Family Trees Part 2. Finding out Diabetics Basing on Their Family Trees Examination and Investigating Heredities on Them kn-title=糖尿病の集団検診と発見患者の家系調査 第2報 家系調査に依る糖尿病の発見と遺伝について en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. 124 cases were found out from 8047 persons who received the mass examination and the discovering rate was 1.5 per cent. 2. 140 cases were checked to be diabetics from 645 persons by their family trees examination with the discovering rate of 23 per cent. 3. Diabetics were found with the discovering rate of 25.6 per cent among persons whose mothers or fathers suffered from diabetes and with 21.13 per cent among persons whose parents had no diabetes. And the former per cent was higher a little than the latter. 4. The rate of having diabetes in their young age was higher among persons in so-called diabetes family trees than in the normal trees, and the death of some persons by the above diabetes of early age was noticed. 5. There were found 9 family trees which had cases more than 3 respectively and 4 family trees which had cases more than 4 being pointed out to be the deep and thick diabetes family trees. 6. It is very necessary to conduct the family trees investigation on the occasion of mass clinical examination. Its reason is as follows: We can find out new cases, especially the early age cases under 30 ages, and that, serious cases among rather small number of persons, and the persons, involving diabetics and non-diabetics, in the diabetes family trees should take care of their own meals from point of the so-called preventing medicine. en-copyright= kn-copyright= en-aut-name=OkumaYoshifumi en-aut-sei=Okuma en-aut-mei=Yoshifumi kn-aut-name=大隈義文 kn-aut-sei=大隈 kn-aut-mei=義文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=9-10 article-no= start-page=401 end-page=404 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19701030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Mass Examination for Finding out Diabetics and Their Family Trees Part 1. Enzymological Quantitative Method on the Urinary Sugar, Especially the Comparison between Glucostat and Tes-Tape Method kn-title=糖尿病の集団検診と発見患者の家系調査 第1報 尿糖の酵素学的定量試験法について，特にGlucostatとTes-Tape法との比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Comparing the quantitative value by glucostat method with that by tes-tape method on the occasion of mass examination for diabetics, the following results were obtained. 1. Both values obtained respectively by glucostat and tes-tape correspond rather well, and so it is considered that tes-tape is available for detecting sucrose material on the mass examination. 2. The upper ground value of the group of normal persons is 0.077mg/ml and the value of the person whose urine is quasipositive to sugar is about 0.121±0.12, and so we must consider over the persons of quasipositive reaction under the condition of that they are not normal. en-copyright= kn-copyright= en-aut-name=OkumaYoshifumi en-aut-sei=Okuma en-aut-mei=Yoshifumi kn-aut-name=大隈義文 kn-aut-sei=大隈 kn-aut-mei=義文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=86 cd-vols= no-issue=9-10 article-no= start-page=415 end-page=444 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=19741030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on application of the speech aid to speech therapy of cleft palate kn-title=口蓋裂患者の言語治療における発音補助装置（Speech aid）の応用に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=I conducted clinical studies on application of the speech aid for the purpose of improving nasopharyngeal function in those patients who still had speech disturbance due to nasopharyngeal insufficiency even after palatal repair. For the treatment of speech disturbance accompanying cleft palate, it is necessary to perform palatal repair to restore nasopharyngeal function to its normal level as early as possible and also to give systematic speech therapy. However, we encounter not infrequently cases with residual speech difficulty due to nasopharyngeal insufficiency even after such palatal repair. For this reason, I carried out clinical studies on 64 cases by applying the speech aid in order to improve their nasopharyngeal function and giving speech therapy. As a result I have drawn the conclusions as follows. 1. For the improvement of nasopharyngeal function and normalization of speech, the speech aid seemed to be indicated for those those patients with expiration loss rate of over 2.1 at the time of blowing with Taguchi's manometer. 2. When the speech aid applied was classified into four types according to the morphology and function of its palatomaxillar section, there were 36 cases (56.2% ) for whom the palatomaxillar section was used for the sole purpose of supporting the pharyngeal section, but in the cases of bilateral and unilateral cleft lip and palate patients there were 63.4% of them for whom speech aid was used for restore the tooth defect and hard palate perforation. 3. Among 29 cases whose cephalometric x-ray films were taken at the time of pronouncing the vowel "a", the cases showing Passavant's bar amounted to 66.5% , where the upper margin of Passavant's bar was in contact with the posterior inferior edge of the pharyngeal section, which coincided with the produced under the direct view of mirror, but in those cases not revealing Passavant's bar there could be observed no definite position-relationship. 4. With growth of the jaw the speech aid applied in 3-5 year old children had to be reconstructed in the majority of cases, and the duration of time from the first speech aid insertion to the first reconstruction set ranged 19 months to 23 months. 5. The speech aid proved to bo effective on nasopharyngeal function in 85.9% of the cases applied, bringing up the respiration loss to O point at the blowing time, which in the majority of them had been attained within 4 months after the application of speech aid. Especially marked was such an effect in those cases whose palato-pharyngeal sphincter function before the application was good, some even showing an immediate effect. 6. As to the speech improvement after the application of speech aid, there were 41.7% , of the cases recovering to normal speech level (degree one), and 22.9% of them who could carry on normal speech (degree two), revealing the application to be most effective in the age range of 3 to 6 years old. 7. As for the relation of speech improvement to repiration loss rate, in the cases whose respiration loss rate recovered to O after the application of speech aid there were 48.8% whose speech improvement reached degree one and 26.8% of them degree two, but in all those whose respiration loss rate did not recover to O, there was recognized a residual cleft palate speech (degree 3) that existed prior to the application of speech aid. 8. After the application of speech aid it required a speech therapy suitable to each individual in a narrow sence for a certain length of time, and most of the patients over one year old but under two years had to be given speech therapy. 9. There were some cases of auditory disturbance with slight hearing difficulty that seemed to affect the speech recovery, hence cases with auditory disturbance require oto-rhinologic therapy. 10. It had been shown that the application of speech aid inhibits speech recovery effect in the cases of markedly low intelligence so that the speech aid was preferably indicated for those with intelligence of over (IQ=80). 11. Factors contributing to the interference of speech recovery were mental disturbance, auditory disturbance and poor family environments, and it is essential to discover the most suitable methods to eradicate these factors or to develop speech therapy most suitable for individual cases. 12. In the cases of unoperated submucous cleft palate, speech aid proved to be effective, for those cases of relatively young age with a good palato-pharyngeal sphineter function. 13. We tried adjustments of speech such as reduction of pharyngeal section by scraping on 20 cases whose speech had recovered to normal, and we found 5 cases whose speech aid could be removed, 8 cases whose pharyngeal section had shrunken, and 7 cases whose one could not be reduced in size. 14. The cases removed of speech aid were lower aged-children and had the good function of the palato-pharyngeal sphincter and the sufficient length of soft palate, and by the age of 7 years both the anterior to posterior diameter and the left-to-right diameter of the pharyngeal section had shrunken to 5 or 6mm and they showed the shrinkage rate of less than 1/2 in comparing that before and after scraping. Macroscopic examinations of these cases revealed the enhancement of the palato-pharyngeal sphincter function, especially marked was the functional improvement of the pharyngeal lateral wall in the majority of cases. In addition, the cephalometric x-ray films showed an improved movement of soft palate, a marked Passavant's bar, and the shortening of the minimum distance between the soft palate and Passavant's bar. 15. From these findings it seemed that in order to achieve the most ideal result with speech aid we should plant to restore speech level to its normal at first with speech aid, then to scrape the pharyngeal section gradually while observing patient's speech manner, and finally to try to remove the speech aid as soon as feasible. en-copyright= kn-copyright= en-aut-name=FujiwaraHiroaki en-aut-sei=Fujiwara en-aut-mei=Hiroaki kn-aut-name=藤原弘旦 kn-aut-sei=藤原 kn-aut-mei=弘旦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部口腔外科学教室 END start-ver=1.4 cd-journal=joma no-vol=81 cd-vols= no-issue=1-2 article-no= start-page=71 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=19690228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of atypical psychosis characterized by periodic stupor, with marked epileptic factors kn-title=著明なてんかん性要因を示し，挿間性昏迷状態をくりかえした非定型精神病の1例 en-subtitle= kn-subtitle= en-abstract=A 16-year old girl. It is said that there was a psychotic case in the relatives on the paternal side of the patient. Her hereditary history remains obscure, but her own history is uneventful. A review was made of this case who had episodes of stuporous state six times, and episodes of delutional-hallucinatory state twice since the age of 13. Clinical and EEG observations were carried out from Nov. 1965 to Aug. 1966, and from March 1967 to July 1967 when she was admitted to our clinic. The results are breifly summarized as follows. The stuporous state which presented mutism and akinesia as the principal symptom was difficult to differentiate from the stupor observable in schizophrenia, and it developed in a day or two at the onset, which lasted for about two weeks and then was alleviated. During this period of episodes she showed no noteworthy symptom of disturbed consciousness and she could recall what had happened to her precisely. Her EEG revealed that paroxysmal abnormal waves characterized by spike wave were inhibited during the stuporous state, but in the stage of remission paroxysmal abnormal waves appeared spontaneously and were activated easily by hyperventilation. This stuporous state could be alleviated transiently by the administration of amytal sodium, and also with a large dose of valium it was improved. On the contrary, anti-epileptic agents had no effect at all on the stuporous state. From the characteristic features of the psychotic state, this case could be construed as a type of atypical psychosis, but paroxysmal abnomality on EEG was similar to that of epilepsy, and so this was the case that had clearly shown to stand on the boundary line between atypical psychosis and epilepsy. Therefore, it seemed that epileptic factors of atypical psychosis should be dicided only after long, continuous observations of the case. Some discussion was made on physiological mechanism inducing a stuporous state. Namely, the mechanism that induced a stuporous state seemed to have a close relation to the excitation of system which tried to inhibit the abnormal EEG, and this system was provably the reticular formation system of the midbrain. kn-abstract=症例は13才女子.患者の7親等にあたる父系に精神病者があつたというが遺伝歴の詳細は不明.既往歴に特記すべきものはない.本症例に招来した前後7回の昏迷状態と,その他幻覚妄想の表面化した,昏迷状態と異なる状態像をあわせ観察し,発病より入院に至る経過,及び前後2回の入院の経過を詳述した.昏迷状態はつよい無動無言を主兆とする分裂病性昏迷と区別のつかないもので,始まりは急で1日を境にして訪れ,2週間前後続き寛解をみる.この間認むべき意識障害はなく,患者は些細な出来事迄すべてを想起できる.前後18回の脳波による継時的観察を行なつた結果,昏迷状態下では,棘波を中心とする発作性異常波は抑制され,寛解期にはこれが出現しやすい傾向を認めた.昏迷状態はAmytal sodiumで,一時的ではあるが劇的に改善され, Valiumの大量内服でも臨床像を改善できた.しかし抗てんかん剤は,むしろ昏迷状態には奏効しなかつた.本症は精神病像からは非定型精神病群の1型としてみられるが,発作波の消長からは,てんかんにみられる所見と同一の傾向を有し,両者を結ぶ1点を鮮やかに示した1例であつた.非定型精神病のてんかん性要因はかかる症例の継時的観察から決定されるべきものであると考えた.その他昏迷状態の出現と,発作波の消長に関し,若干の生理学的推論を試み,考察を加えた. en-copyright= kn-copyright= en-aut-name=HosokawaK. en-aut-sei=Hosokawa en-aut-mei=K. kn-aut-name=細川清 kn-aut-sei=細川 kn-aut-mei=清 aut-affil-num=1 ORCID= en-aut-name=NishimuraS. en-aut-sei=Nishimura en-aut-mei=S. kn-aut-name=西村幸子 kn-aut-sei=西村 kn-aut-mei=幸子 aut-affil-num=2 ORCID= en-aut-name=IkedaH. en-aut-sei=Ikeda en-aut-mei=H. kn-aut-name=池田久男 kn-aut-sei=池田 kn-aut-mei=久男 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学神経精神医学教室 affil-num=2 en-affil= kn-affil=岡山大学神経精神医学教室 affil-num=3 en-affil= kn-affil=岡山大学神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=86 cd-vols= no-issue=1-2 article-no= start-page=47 end-page=52 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=19740228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Incidence of hepatitis in hemodialysis patient in Okayama Prefecture kn-title=岡山県下の人工透析患者の肝炎発生状況 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Incidence of hepatitis affecting hemodialysis patients was investigated by inquiry on one hundred and twenty-one cases who were on dialysis treatment in ten hemodialysis units in Okayama Prefedture. Items of inquiry were the history of hepatitis, blood transfusion and jaundice; and GOT, GPT, Australia antigen & antibody measured in these units before and after hemodialysis treatment. Recovery of inquiry was 96.6% and investigated group was consisted of seventy-five male and fourty-two female. Thirty-six cases had the history of hepatitis (30.8%). Abnormality of liver function test (TTT, ZTT, GOT, GPT) was increased about two times after hemodialysis treatment than before. Abnormality of GOT or GPT in one hundred and three cases measured by authors was 20.4% and 28.2%, respectively. Longer period of hemodialysis and more blood transfusion showed more high abnormality of GPT. These results indicate the transfusion was the important factor of occurence of hepatitis, again. en-copyright= kn-copyright= en-aut-name=KondoTadasuke en-aut-sei=Kondo en-aut-mei=Tadasuke kn-aut-name=近藤忠亮 kn-aut-sei=近藤 kn-aut-mei=忠亮 aut-affil-num=1 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=2 ORCID= en-aut-name=KunitomoKeiichi en-aut-sei=Kunitomo en-aut-mei=Keiichi kn-aut-name=国友桂一 kn-aut-sei=国友 kn-aut-mei=桂一 aut-affil-num=3 ORCID= en-aut-name=KokumaiYoshiaki en-aut-sei=Kokumai en-aut-mei=Yoshiaki kn-aut-name=国米欣明 kn-aut-sei=国米 kn-aut-mei=欣明 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科 affil-num=3 en-affil= kn-affil=岡山大学医学部人工腎臓室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科 END