フルテキストURL Chemistry_23_68_17191.pdf
著者 Takamura, Hiroyoshi| Katsube, Tomoya| Okamoto, Kazuki| Kadota, Isao|
抄録 The first total synthesis of two possible diastereomers of natural 6-chlorotetrahydrofuran acetogenin 1 has been achieved. The synthetic route features 5-exo-tet cyclization, Z selective Wittig reaction and Julia olefination for the construction of conjugated diene and enyne moieties, and stereoselective chlorination. Comparison of their 1 H and 13 C NMR data and specific rotation with those of the natural product elucidated the absolute configuration of natural (-)-6-chlorotetrahydrofuran acetogenin 1.
キーワード natural products stereoselective synthesis structure elucidation tetrahydrofuran total synthesis
備考 This is an article published by Wiley‐VCH
発行日 2017-12-06
出版物タイトル Chemistry - A European Journal
23巻
68号
出版者 Wiley‐VCH
開始ページ 17191
終了ページ 17194
ISSN 09476539
NCID AA11076269
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 29083058
DOI 10.1002/chem.201703234
Web of Sience KeyUT 000417508800005
関連URL isVersionOf https://doi.org/10.1002/chem.201703234