start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=22 article-no= start-page=3306 end-page=3309 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=2009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Fabricating small-scale, curved, polymeric structures with convex and concave menisci through interfacial free energy equilibrium en-subtitle= kn-subtitle= en-abstract= kn-abstract=Polymeric curved structures are widely used in imaging systems including optical fibers and microfluidic channels. Here, we demonstrate that small-scale, poly(dimethylsiloxane) (PDMS)-based, curved structures can be fabricated through controlling interfacial free energy equilibrium. Resultant structures have a smooth, symmetric, curved surface, and may be convex or concave in form based on surface tension balance. Their curvatures are controlled by surface characteristics (i.e., hydrophobicity and hydrophilicity) of the molds and semi-liquid PDMS. In addition, these structures are shown to be biocompatible for cell culture. Our system provides a simple, efficient and economical method for generating integrateable optical components without costly fabrication facilities. en-copyright= kn-copyright= en-aut-name=ChengChao-Min en-aut-sei=Cheng en-aut-mei=Chao-Min kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuuraKoji en-aut-sei=Matsuura en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WangI-Jan en-aut-sei=Wang en-aut-mei=I-Jan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KurodaYuka en-aut-sei=Kuroda en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=LeDucPhilip R. en-aut-sei=LeDuc en-aut-mei=Philip R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NaruseKeiji en-aut-sei=Naruse en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University affil-num=2 en-affil= kn-affil=Research Core for Interdisciplinary Sciences, Okayama University affil-num=3 en-affil= kn-affil=Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University affil-num=4 en-affil= kn-affil=Research Core for Interdisciplinary Sciences, Okayama University affil-num=5 en-affil= kn-affil=Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University affil-num=6 en-affil= kn-affil=Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue=7 article-no= start-page=607 end-page=610 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110428 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Quantification of the orientations of pyrrolidine-based oxypeptide nucleic acid?DNA hybrid duplexes en-subtitle= kn-subtitle= en-abstract= kn-abstract=We describe the fluorescence quenching-based quantification of complementary parallel and antiparallel hybrids of DNAs with pyrrolidine-based oxypeptide nucleic acids (POPNAs). When BODIPY-modified DNAs as fluorescent probe formed hybrids with complementary POPNAs, fluorescence of the BODIPY was effectively quenched by the guanine unit and the Lys unit on the POPNAs. The orientations of hybrids of POPNA with DNA were estimated by the quenching efficiencies of two BODIPY-modified DNAs . As a result, we clarified that configurations of POPNAs affect the extent of orientation of the hybrid duplexes. en-copyright= kn-copyright= en-aut-name=KitamatsuMizuki en-aut-sei=Kitamatsu en-aut-mei=Mizuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SisidoMasahiko en-aut-sei=Sisido en-aut-mei=Masahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Medical and Bioengineering, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil= END