start-ver=1.4
cd-journal=joma
no-vol=94
cd-vols=
no-issue=4
article-no=
start-page=500
end-page=509
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=200510
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Polyphenol levels in human urine after intake of six different polyphenol-rich beverages
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Dietary polyphenols are suggested to participate in the prevention of CVD and cancer. It is essential for epidemiological studies to be able to compare intake
of the main dietary polyphenols in populations. The present paper describes a fast method suitable for the analysis of polyphenols in urine, selected as
potential biomarkers of intake. This method is applied to the estimation of polyphenol recovery after ingestion of six different polyphenol-rich beverages.
Fifteen polyphenols including mammalian lignans (enterodiol and enterolactone), several phenolic acids (chlorogenic, caffeic, m-coumaric, gallic, and 4-Omethylgallic
acids), phloretin and various flavonoids (catechin, epicatechin, quercetin, isorhamnetin, kaempferol, hesperetin, and naringenin) were simultaneously
quantified in human urine by HPLC coupled with electrospray ionisation mass-MS (HPLC-electrospray-tandem mass spectrometry) with a run
time of 6 min per sample. The method has been validated with regard to linearity, precision, and accuracy in intra- and inter-day assays. It was applied
to urine samples collected from nine volunteers in the 24 h following consumption of either green tea, a grape-skin extract, cocoa beverage, coffee, grapefruit
juice or orange juice. Levels of urinary excretion suggest that chlorogenic acid, gallic acid, epicatechin, naringenin or hesperetin could be used as
specific biomarkers to evaluate the consumption of coffee, wine, tea or cocoa, and citrus juices respectively.
en-copyright=
kn-copyright=

en-aut-name=ItoHideyuki
en-aut-sei=Ito
en-aut-mei=Hideyuki
kn-aut-name=伊東秀之
kn-aut-sei=伊東
kn-aut-mei=秀之
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=Marie-PauleGonthier
kn-aut-sei=Marie-Paule
kn-aut-mei=Gonthier
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=ClaudineManach
kn-aut-sei=Claudine
kn-aut-mei=Manach
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=ChristineMorand
kn-aut-sei=Christine
kn-aut-mei=Morand
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=LouiseMennen
kn-aut-sei=Louise
kn-aut-mei=Mennen
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=ChristianR?m?sy
kn-aut-sei=Christian
kn-aut-mei=R?m?sy
aut-affil-num=6
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=AugustinScalbert
kn-aut-sei=Augustin
kn-aut-mei=Scalbert
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学薬学部

affil-num=2
en-affil=
kn-affil=Unit? des Maladies M?taboliques et Micronutrients

affil-num=3
en-affil=
kn-affil=Unit? des Maladies M?taboliques et Micronutrients

affil-num=4
en-affil=
kn-affil=Unit? des Maladies M?taboliques et Micronutrients

affil-num=5
en-affil=
kn-affil=UMR INSERM U557/INRA/CNAM

affil-num=6
en-affil=
kn-affil=Unit? des Maladies M?taboliques et Micronutrients

affil-num=7
en-affil=
kn-affil=Unit? des Maladies M?taboliques et Micronutrients
en-keyword=Polyphenols
kn-keyword=Polyphenols
en-keyword=Flavonoids
kn-keyword=Flavonoids
en-keyword=Phenolic acids
kn-keyword=Phenolic acids
en-keyword=High-throughput analysis
kn-keyword=High-throughput analysis
en-keyword=Urine
kn-keyword=Urine
en-keyword=Beverages
kn-keyword=Beverages
END