start-ver=1.4 cd-journal=joma no-vol=387 cd-vols= no-issue=6 article-no= start-page=2057 end-page=2064 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate as an effective solvent mediator for a mexiletine-sensitive membrane electrode en-subtitle= kn-subtitle= en-abstract= kn-abstract=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate proved to be an effective solvent mediator for constructing a mexiletine-sensitive membrane electrode in combination with an ion-exchanger, sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate. Among a series of phosphorus compounds containing phosphoryl (P=O) groups, this solvent mediator showed the highest sensitivity to mexiletine in phosphate-buffered physiological saline containing 0.15 mol L-1 NaCl and 0.01 mol L-1 NaH2PO4/Na2HPO4 (pH 7.4), giving a detection limit of 2 x 10(-6) mol L-1 with a slope of 58.8 mV decade(-1). This is the best reported detection limit of any mexiletine-sensitive electrode developed to date. Owing to its high selectivity toward inorganic cations, the electrode was used to determine the level of mexiletine in saliva, the monitoring of which is quite effective for controlling the dose of this drug noninvasively. The mexiletine concentrations determined with the mexiletine-sensitive electrode compared favorably with those determined by high-performance liquid chromatography. en-copyright= kn-copyright= en-aut-name=KatsuTakashi en-aut-sei=Katsu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsunamotoYumi en-aut-sei=Tsunamoto en-aut-mei=Yumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HaniokaNobumitsu en-aut-sei=Hanioka en-aut-mei=Nobumitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KomagoeKeiko en-aut-sei=Komagoe en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MasudaKazufumi en-aut-sei=Masuda en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NarimatsuShizuo en-aut-sei=Narimatsu en-aut-mei=Shizuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=Ion-selective electrode kn-keyword=Ion-selective electrode en-keyword=Mexiletine determination kn-keyword=Mexiletine determination en-keyword=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate kn-keyword=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate en-keyword=Solvent mediator kn-keyword=Solvent mediator en-keyword=Drug monitoring kn-keyword=Drug monitoring END