start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=3
article-no=
start-page=247
end-page=254
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=201604
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A prospective randomized trial comparing the clinical effectiveness and biocompatibility of heparin-coated circuits and PMEA-coated circuits in pediatric cardiopulmonary bypass
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=OBJECT:　
We compared the clinical effectiveness and biocompatibility of poly-2-methoxyethyl acrylate (PMEA)-coated and heparin-coated cardiopulmonary bypass (CPB) circuits in a prospective pediatric trial.　
METHODS:　
Infants randomly received heparin-coated (n=7) or PMEA-coated (n=7) circuits in elective pediatric cardiac surgery with CPB for ventricular septum defects. Clinical and hematologic variables, respiratory indices and hemodynamic changes were analyzed perioperatively.　
RESULTS:　
Demographic and clinical variables were similar in both groups. Leukocyte counts were significantly lower 5 minutes after CPB in the PMEA group than the heparin group. Hemodynamic data showed that PMEA caused hypotension within 5 minutes of CPB. The respiratory index was significantly higher immediately after CPB and 1 hour after transfer to the intensive care unit (ICU) in the PMEA group, as were levels of C-reactive protein 24 hours after transfer to the ICU.　
CONCLUSION:　
Our study shows that PMEA-coated circuits, unlike heparin-coated circuits, cause transient leukopenia during pediatric CPB and, perhaps, systemic inflammatory respiratory syndrome after pediatric CPB.
en-copyright=
kn-copyright=

en-aut-name=ItohHideshi
en-aut-sei=Itoh
en-aut-mei=Hideshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name= IchibaShing
en-aut-sei= Ichiba
en-aut-mei=Shing
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UjikeYoshihito
en-aut-sei=Ujike
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=DouguchiTakuma
en-aut-sei=Douguchi
en-aut-mei=Takuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KasaharaShingo
en-aut-sei=Kasahara
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AraiSadahiko
en-aut-sei=Arai
en-aut-mei=Sadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SanoShunji
en-aut-sei=Sano
en-aut-mei=Shunji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Community and Emergency Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=
kn-affil=

affil-num=5
en-affil=Department of Cardiovascular Surgery, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Cardiovascular Surgery, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Surgery, Okayama University Hospital
kn-affil=
en-keyword=PMEA coating
kn-keyword=PMEA coating
en-keyword=cardiopulmonary bypass
kn-keyword=cardiopulmonary bypass
en-keyword=heparin coating
kn-keyword=heparin coating
en-keyword=pediatric
kn-keyword=pediatric
en-keyword=transient leukopenia
kn-keyword=transient leukopenia
END

start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=5
article-no=
start-page=648
end-page=652
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of Rapid Immunochromatographic Tests for Norovirus in Neonatal and Infant Faecal Specimens
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objectives: To compare the diagnostic performance of two norovirus rapid immunochromatographic kits (QuickNavi(®)-Norovirus [QN] and QuickNavi®-Norovirus 2 [QN2]; Denka Seiken, Niigata, Japan) for neonatal and infant faecal specimens.<br/>
Methods: Monthly faecal samples were collected from infants from birth to 12 months of age, and tested for norovirus using QN and QN2. Real-time reverse transcription polymerase chain reaction (RT-PCR) was used as the gold standard for norovirus detection. The diagnostic performance of the kits was calculated.<br/>
Results: A total of 343 specimens from 81 infants were analysed. In all samples, the specificity of QN and QN2 was 80% (275/343) and 99% (339/343), respectively. In infants aged <1 month, the specificity of QN was 33% (23/70), increasing to 93% at 4 months of age. Specificity of QN2 was ≥94% in infants between 0 and 12 months of age.<br/>
Conclusions: QN2 offers improved performance and is more useful than QN for the diagnosis of norovirus infection in the neonatal and infant period.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=TakahashiNobumasa
kn-aut-sei=Takahashi
kn-aut-mei=Nobumasa
aut-affil-num=1
ORCID=

en-aut-name=NojimaIkuko
en-aut-sei=Nojima
en-aut-mei=Ikuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ArakiTooru
en-aut-sei=Araki
en-aut-mei=Tooru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakasugiMizue
en-aut-sei=Takasugi
en-aut-mei=Mizue
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SakaneTomoko
en-aut-sei=Sakane
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KoderaAya
en-aut-sei=Kodera
en-aut-mei=Aya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IkedaMasanori
en-aut-sei=Ikeda
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TsukaharaHirokazu
en-aut-sei=Tsukahara
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Paediatrics, Fukuyama Medical Centre
kn-affil=

affil-num=2
en-affil=Department of Paediatrics, Fukuyama Medical Centre
kn-affil=

affil-num=3
en-affil=Department of Paediatrics, Fukuyama Medical Centre
kn-affil=

affil-num=4
en-affil=Department of Paediatrics, Fukuyama Medical Centre
kn-affil=

affil-num=5
en-affil=Department of Paediatrics, Fukuyama Medical Centre
kn-affil=

affil-num=6
en-affil=Department of Paediatrics, Fukuyama Medical Centre
kn-affil=

affil-num=7
en-affil=Department of Paediatrics, Fukuyama Medical Centre
kn-affil=

affil-num=8
en-affil=Department of Paediatrics, Okayama University Hospital
kn-affil=
en-keyword=Norovirus
kn-keyword=Norovirus
en-keyword=false positive
kn-keyword=false positive
en-keyword=immunochromatography
kn-keyword=immunochromatography
en-keyword=neonate
kn-keyword=neonate
en-keyword=rapid detection test
kn-keyword=rapid detection test
en-keyword=specificity
kn-keyword=specificity
END