ID | 46941 |
フルテキストURL | |
著者 |
Kitamatsu, Mizuki
Department of Bioscience and Biotechnology, Okayama University
Kaken ID
publons
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Takahashi, Akiko
Department of Bioscience and Biotechnology, Okayama University
Ohtsuki, Takashi
Department of Bioscience and Biotechnology, Okayama University
ORCID
Kaken ID
publons
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Sisido, Masahiko
Department of Bioscience and Biotechnology, Okayama University
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抄録 | We synthesized 16 pyrrolidine-based oxy-peptide nucleic acid (POPNA) monomers carrying four different nucleobases onto four different stereoisomers of pyrrolidine rings. Using these monomers, we prepared POPNA oligomers, which formed sequence-specific hybrids with DNAs. The oligomer configurations influenced the hybrid stability. The oligomers were not taken into CHO cells. However, they could enter the cell cytoplasm when mixed with the influenza virus hemagglutinin peptide-arginine heptamer conjugate.
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キーワード | Peptide nucleic acid
Solid-phase peptide synthesis
Cell-penetrating peptide
Confocal laser scanning microscopy
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発行日 | 2010-12-18
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出版物タイトル |
Tetrahedron
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巻 | 66巻
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号 | 51号
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出版者 | Pergamon-Elsevier Science Ltd.
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開始ページ | 9659
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終了ページ | 9666
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ISSN | 0040-4020
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NCID | AA00861787
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | © 2010 Elsevier Ltd. All rights reserved.
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT |