このエントリーをはてなブックマークに追加
ID 46941
フルテキストURL
著者
Kitamatsu, Mizuki Department of Bioscience and Biotechnology, Okayama University
Takahashi, Akiko Department of Bioscience and Biotechnology, Okayama University
Ohtsuki, Takashi Department of Bioscience and Biotechnology, Okayama University ORCID Kaken ID publons researchmap
Sisido, Masahiko Department of Bioscience and Biotechnology, Okayama University
抄録
We synthesized 16 pyrrolidine-based oxy-peptide nucleic acid (POPNA) monomers carrying four different nucleobases onto four different stereoisomers of pyrrolidine rings. Using these monomers, we prepared POPNA oligomers, which formed sequence-specific hybrids with DNAs. The oligomer configurations influenced the hybrid stability. The oligomers were not taken into CHO cells. However, they could enter the cell cytoplasm when mixed with the influenza virus hemagglutinin peptide-arginine heptamer conjugate.
キーワード
Peptide nucleic acid
Solid-phase peptide synthesis
Cell-penetrating peptide
Confocal laser scanning microscopy
発行日
2010-12-18
出版物タイトル
Tetrahedron
66巻
51号
出版者
Pergamon-Elsevier Science Ltd.
開始ページ
9659
終了ページ
9666
ISSN
0040-4020
NCID
AA00861787
資料タイプ
学術雑誌論文
言語
English
著作権者
© 2010 Elsevier Ltd. All rights reserved.
論文のバージョン
author
査読
有り
DOI
Web of Science KeyUT