start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=43
article-no=
start-page=151189
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190920
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fluorescence properties of amido-substituted 2,3-naphthalimides: Excited-state intramolecular proton transfer (ESIPT) fluorescence and responses to Ca2+ ions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= 2,3-Naphthalimide derivatives incorporating trifluoroacetamido (3a) and methansulfonamido (3b) functionalities at the 1-position were prepared and their intramolecular excited state proton transfer (ESIPT) fluorescence and responses to metal ions were investigated. Compound 3a displayed normal fluorescence in the amide form in toluene and MeCN and no response to metal cations in the corresponding amidate ion form. In contrast, compound 3b gave off dual emission assignable to normal and ESIPT fluorescence. Additionally, the amidate form of compound 3b displayed off-on fluorescence response to Ca2+.
en-copyright=
kn-copyright=
en-aut-name=WangLei
en-aut-sei=Wang
en-aut-mei=Lei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=FujiiMayu
en-aut-sei=Fujii
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NambaMisa
en-aut-sei=Namba
en-aut-mei=Misa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YamajiMinoru
en-aut-sei=Yamaji
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=OkamotoHideki
en-aut-sei=Okamoto
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
affil-num=2
en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
affil-num=3
en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
affil-num=4
en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University
kn-affil=
affil-num=5
en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Fluorescence
kn-keyword=Fluorescence
en-keyword=ESIPT
kn-keyword=ESIPT
en-keyword=Naphthalimide
kn-keyword=Naphthalimide
en-keyword=Ca2+ probe
kn-keyword=Ca2+ probe
END
start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=24
article-no=
start-page=1562
end-page=1565
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190613
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Efficient and practical synthesis of N-acetyl enamides from ketoximes by unique iron catalytic system
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A new procedure for the iron-catalyzed synthesis of enamides from ketoximes was developed, and its mechanism was proposed. A unique reduction system, with the concerted use of KI and Na2S2O4, was involved. The reaction exhibited a wide substrate scope and gave good yields in a short reaction time. The procedure is operationally simple and also applicable for the large-scale synthesis.
en-copyright=
kn-copyright=
en-aut-name=Kunishige Takahiro
en-aut-sei=Kunishige
en-aut-mei= Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=Sawada Daisuke
en-aut-sei=Sawada
en-aut-mei= Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Ketoxime
kn-keyword=Ketoxime
en-keyword=Enamide synthesis
kn-keyword=Enamide synthesis
en-keyword=Iron catalyst
kn-keyword=Iron catalyst
en-keyword=One-electron reduction
kn-keyword=One-electron reduction
END
start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=
article-no=
start-page=38
end-page=46
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Hyperoxia reduces salivary secretion by inducing oxidative stress in mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=OBJECTIVE:
The aim of this study was to determine the effects of prolonged hyperoxia on salivary glands and salivary secretion in mice.
DESIGN:
Male C57BL/6?J mice were kept in a 75% oxygen chamber (hyperoxia group) or a 21% oxygen chamber for 5 days. We measured the secretion volume, protein concentration, and amylase activity of saliva after the injection of pilocarpine. In addition, we evaluated the histological changes induced in the submandibular glands using hematoxylin and eosin and Alcian blue staining and assessed apoptotic changes using the TdT-mediated dUTP nick end labeling (TUNEL) assay. We also compared the submandibular gland expression levels of heme oxygenase-1 (HO-1), superoxide dismutase (SOD)-1, and SOD-2 using the real-time polymerase chain reaction.
RESULTS:
In the hyperoxia group, salivary secretion was significantly inhibited at 5 and 10?min after the injection of pilocarpine, and the total salivary secretion volume was significantly decreased. The salivary protein concentration and amylase activity were also significantly higher in the hyperoxia group. In the histological examinations, enlargement of the mucous acini and the accumulation of mucins were observed in the submandibular region in the hyperoxia group, and the number of TUNEL-positive cells was also significantly increased in the hyperoxia group. Moreover, the expression levels of HO-1, SOD-1, and SOD-2 were significantly higher in the hyperoxia group.
CONCLUSION:
Our results suggest that hyperoxia reduces salivary secretion, and oxidative stress reactions might be involved in this.
en-copyright=
kn-copyright=
en-aut-name=TajiriAyako
en-aut-sei=Tajiri
en-aut-mei=Ayako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=HiguchiHitoshi
en-aut-sei=Higuchi
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MiyawakiTakuya
en-aut-sei=Miyawaki
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
affil-num=1
en-affil=Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Dental Anesthesiology, Okayama University Hospital
kn-affil=
affil-num=3
en-affil=Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Hyperoxia
kn-keyword=Hyperoxia
en-keyword=Hyposalivation
kn-keyword=Hyposalivation
en-keyword=Oxidative stress
kn-keyword=Oxidative stress
en-keyword=Saliva
kn-keyword=Saliva
END