start-ver=1.4
cd-journal=joma
no-vol=2024
cd-vols=
no-issue=11
article-no=
start-page=113D01
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241026
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Measurement of γ-Rays Generated by Neutron Interaction with 16O at 30 MeV and 250 MeV
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Deep understanding of γ-ray production from the fast neutron reaction in water is crucial for various physics studies at large-scale water Cherenkov detectors. We performed test experiments using quasi-mono energetic neutron beams (⁠En = 30 and 250 MeV) at Osaka University’s Research Center for Nuclear Physics to measure γ-rays originating from the neutron–oxygen reaction with a high-purity germanium detector. Multiple γ-ray peaks which are expected to be from excited nuclei after the neutron–oxygen reaction were successfully observed. We measured the neutron beam flux using an organic liquid scintillator for the cross section measurement. With a spectral fitting analysis based on the tailored γ-ray signal and background templates, we measured cross sections for each observed γ-ray component. The results will be useful to validate neutron models employed in ongoing and future water Cherenkov experiments.
en-copyright=
kn-copyright=

en-aut-name=TanoT.
en-aut-sei=Tano
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HoraiT.
en-aut-sei=Horai
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AshidaY.
en-aut-sei=Ashida
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HinoY.
en-aut-sei=Hino
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IacobF.
en-aut-sei=Iacob
en-aut-mei=F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MaurelA.
en-aut-sei=Maurel
en-aut-mei=A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MoriM.
en-aut-sei=Mori
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=CollazuolG.
en-aut-sei=Collazuol
en-aut-mei=G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KonakaA.
en-aut-sei=Konaka
en-aut-mei=A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KoshioY.
en-aut-sei=Koshio
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NakayaT.
en-aut-sei=Nakaya
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=ShimaT.
en-aut-sei=Shima
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=WendellR.
en-aut-sei=Wendell
en-aut-mei=R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Physics and Astronomy, University of Utah
kn-affil=

affil-num=4
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Physics and Astronomy, University of Padova
kn-affil=

affil-num=6
en-affil=Ecole Polytechnique, IN2P3-CNRS, Laboratoire Leprince-Ringuet
kn-affil=

affil-num=7
en-affil=National Astronomical Observatory of Japan
kn-affil=

affil-num=8
en-affil=Department of Physics and Astronomy, University of Padova
kn-affil=

affil-num=9
en-affil=TRIUMF
kn-affil=

affil-num=10
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Physics, Kyoto University
kn-affil=

affil-num=12
en-affil=Research Center for Nuclear Physics (RCNP)
kn-affil=

affil-num=13
en-affil=Department of Physics, Kyoto University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=2024
cd-vols=
no-issue=10
article-no=
start-page=103D01
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Study of the Neutrino–Oxygen Cross Sections of the Charged-Current Reaction 16O(ν̄e, e+)16N(0 MeV, 2–) and the Neutral-Current Reaction 16O(ν, ν′)16O(12.97/12.53 MeV, 2–), Producing High-Energy γ Rays
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In our previous work, we discussed the cross section and the detection of 4.4 MeV γ rays produced in the neutrino  neutral-current (NC)reaction 16O(ν, ν′)16O(12.97 and 12.53 MeV, 2−) in a water Cherenkov detector at low energy below 100 MeV. In this report, we further investigate both the charged-current reaction 16O(ν¯e, e+)16N(0 MeV, 2−) and the NC reaction16O(ν, ν′)16O(12.97 and 12.53 MeV, 2−), producing high-energy γ rays, in which a more solid identification of the reactions can be applied via the coincidence method.
en-copyright=
kn-copyright=

en-aut-name=SakudaMakoto
en-aut-sei=Sakuda
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SuzukiToshio
en-aut-sei=Suzuki
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakazatoKen'Ichiro
en-aut-sei=Nakazato
en-aut-mei=Ken'Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SuzukiHideyuki
en-aut-sei=Suzuki
en-aut-mei=Hideyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Physics Department, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Physics, College of Humanities and Sciences, Nihon University
kn-affil=

affil-num=3
en-affil=Faculty of Arts and Science, Kyushu University
kn-affil=

affil-num=4
en-affil=Department of Physics, Faculty of Science and Technology, Tokyo University of Science
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=8
article-no=
start-page=ziae085
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240704
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Macrophages modulate mesenchymal stem cell function via tumor necrosis factor alpha in tooth extraction model
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Mesenchymal stem cells (MSCs) and macrophages collaboratively contribute to bone regeneration after injury. However, detailed mechanisms underlying the interaction between MSCs and inflammatory macrophages (M1) remain unclear. A macrophage-depleted tooth extraction model was generated in 5-wk-old female C57BL/6J mice using clodronate liposome (12.5 mg/kg/mouse, intraperitoneally) or saline injection (control) before maxillary first molar extraction. Mice were sacrificed on days 1, 3, 5, 7, and 10 after tooth extraction (n = 4). Regenerated bone volume evaluation of tooth extraction socket (TES) and histochemical analysis of CD80+M1, CD206+M2 (anti-inflammatory macrophages), PDGFRα+MSC, and TNF-α+ cells were performed. In vitro, isolated MSCs with or without TNF-α stimulation (10 ng/mL, 24 h, n = 3) were bulk RNA-sequenced (RNA-Seq) to identify TNF-α stimulation-specific MSC transcriptomes. Day 7 micro-CT and HE staining revealed significantly lower mean bone volume (clodronate vs control: 0.01 mm3 vs 0.02 mm3, p<.0001) and mean percentage of regenerated bone area per total TES in clodronate group (41.97% vs 54.03%, p<.0001). Clodronate group showed significant reduction in mean number of CD80+, TNF-α+, PDGFRα+, and CD80+TNF-α+ cells on day 5 (306.5 vs 558.8, p<.0001; 280.5 vs 543.8, p<.0001; 365.0 vs 633.0, p<.0001, 29.0 vs 42.5, p<.0001), while these cells recovered significantly on day 7 (493.3 vs 396.0, p=.0004; 479.3 vs 384.5, p=.0008; 593.0 vs 473.0, p=.0010, 41.0 vs 32.5, p=.0003). RNA-Seq analysis showed that 15 genes (|log2FC| > 5.0, log2TPM > 5) after TNF-α stimulation were candidates for regulating MSC’s immunomodulatory capacity. In vivo, Clec4e and Gbp6 are involved in inflammation and bone formation. Clec4e, Gbp6, and Cxcl10 knockdown increased osteogenic differentiation of MSCs in vitro. Temporal reduction followed by apparent recovery of TNF-α-producing M1 macrophages and MSCs after temporal macrophage depletion suggests that TNF-α activated MSCs during TES healing. In vitro mimicking the effect of TNF-α on MSCs indicated that there are 15 candidate MSC genes for regulation of immunomodulatory capacity.
en-copyright=
kn-copyright=

en-aut-name=MunAung Ye
en-aut-sei=Mun
en-aut-mei=Aung Ye
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AkiyamaKentaro
en-aut-sei=Akiyama
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangZiyi
en-aut-sei=Wang
en-aut-mei=Ziyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ZhangJiewen
en-aut-sei=Zhang
en-aut-mei=Jiewen
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KitagawaWakana
en-aut-sei=Kitagawa
en-aut-mei=Wakana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KohnoTeisaku
en-aut-sei=Kohno
en-aut-mei=Teisaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TagashiraRyuji
en-aut-sei=Tagashira
en-aut-mei=Ryuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshibashiKei
en-aut-sei=Ishibashi
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MatsunagaNaoya
en-aut-sei=Matsunaga
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ZouTingling
en-aut-sei=Zou
en-aut-mei=Tingling
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OnoMitsuaki
en-aut-sei=Ono
en-aut-mei=Mitsuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KubokiTakuo
en-aut-sei=Kuboki
en-aut-mei=Takuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=cytokines
kn-keyword=cytokines
en-keyword=dental biology
kn-keyword=dental biology
en-keyword=injury healing
kn-keyword=injury healing
en-keyword=osteoimmunology
kn-keyword=osteoimmunology
en-keyword=stem cells
kn-keyword=stem cells
END

start-ver=1.4
cd-journal=joma
no-vol=65
cd-vols=
no-issue=4
article-no=
start-page=491
end-page=499
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240628
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparison of mutation spectra induced by gamma-rays and carbon ion beams
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The ionizing radiation with high linear energy transfer (LET), such as a heavy ion beam, induces more serious biological effects than low LET ones, such as gamma- and X-rays. This indicates a difference in the DNA damage produced by low and high LET radiations and their biological effects. We have been studying the differences in DNA damage produced by gamma-rays and carbon ion beams. Therefore, we analyze mutations induced by both ionizing radiations to discuss the differences in their biological effects in this study. pUC19 plasmid DNA was irradiated by carbon ion beams in the solution containing 1M dimethyl sulfoxide to mimic a cellular condition. The irradiated DNA was cloned in competent cells of Escherichia coli. The clones harboring some mutations in the region of lacZ alpha were selected, and the sequence alterations were analyzed. A one-deletion mutation is significant in the carbon-irradiated DNA, and the C:G <-> T:A transition is minor. On the other hand, the gamma-irradiated DNA shows mainly G:C <-> T:A transversion. These results suggest that carbon ion beams produce complex DNA damage, and gamma-rays are prone to single oxidative base damage, such as 8-oxoguanine. Carbon ion beams can also introduce oxidative base damage, and the damage species is 5-hydroxycytosine. This was consistent with our previous results of DNA damage caused by heavy ion beams. We confirmed the causal DNA damage by mass spectrometry for these mutations.
en-copyright=
kn-copyright=

en-aut-name=TokuyamaYuka
en-aut-sei=Tokuyama
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MoriKanae
en-aut-sei=Mori
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IsobeMidori
en-aut-sei=Isobe
en-aut-mei=Midori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TeratoHiroaki
en-aut-sei=Terato
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Analytical Research Center for Experimental Science, Saga University
kn-affil=

affil-num=2
en-affil=Analytical Research Center for Experimental Science, Saga University
kn-affil=

affil-num=3
en-affil=Advanced Science Research Center, Okayama University
kn-affil=

affil-num=4
en-affil=Advanced Science Research Center, Okayama University
kn-affil=
en-keyword=base damage
kn-keyword=base damage
en-keyword=mutation
kn-keyword=mutation
en-keyword=gamma-rays
kn-keyword=gamma-rays
en-keyword=heavy ion beam
kn-keyword=heavy ion beam
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=10
article-no=
start-page=5825
end-page=5840
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240425
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The ABCF proteins in Escherichia coli individually cope with 'hard-to-translate' nascent peptide sequences
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Organisms possess a wide variety of proteins with diverse amino acid sequences, and their synthesis relies on the ribosome. Empirical observations have led to the misconception that ribosomes are robust protein factories, but in reality, they have several weaknesses. For instance, ribosomes stall during the translation of the proline-rich sequences, but the elongation factor EF-P assists in synthesizing proteins containing the poly-proline sequences. Thus, living organisms have evolved to expand the translation capability of ribosomes through the acquisition of translation elongation factors. In this study, we have revealed that Escherichia coli ATP-Binding Cassette family-F (ABCF) proteins, YheS, YbiT, EttA and Uup, individually cope with various problematic nascent peptide sequences within the exit tunnel. The correspondence between noncanonical translations and ABCFs was YheS for the translational arrest by nascent SecM, YbiT for poly-basic sequence-dependent stalling and poly-acidic sequence-dependent intrinsic ribosome destabilization (IRD), EttA for IRD at the early stage of elongation, and Uup for poly-proline-dependent stalling. Our results suggest that ATP hydrolysis-coupled structural rearrangement and the interdomain linker sequence are pivotal for handling 'hard-to-translate' nascent peptides. Our study highlights a new aspect of ABCF proteins to reduce the potential risks that are encoded within the nascent peptide sequences. Graphical Abstract
en-copyright=
kn-copyright=

en-aut-name=ChadaniYuhei
en-aut-sei=Chadani
en-aut-mei=Yuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamanouchiShun
en-aut-sei=Yamanouchi
en-aut-mei=Shun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UemuraEri
en-aut-sei=Uemura
en-aut-mei=Eri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamasakiKohei
en-aut-sei=Yamasaki
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NiwaTatsuya
en-aut-sei=Niwa
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IkedaToma
en-aut-sei=Ikeda
en-aut-mei=Toma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KuriharaMiku
en-aut-sei=Kurihara
en-aut-mei=Miku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IwasakiWataru
en-aut-sei=Iwasaki
en-aut-mei=Wataru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TaguchiHideki
en-aut-sei=Taguchi
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Biological Sciences, Graduate School of Science, the University of Tokyo
kn-affil=

affil-num=3
en-affil=Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
kn-affil=

affil-num=4
en-affil=Faculty of Science, Okayama University
kn-affil=

affil-num=5
en-affil=Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
kn-affil=

affil-num=6
en-affil=School of Life Science and Technology, Tokyo Institute of Technology
kn-affil=

affil-num=7
en-affil=School of Life Science and Technology, Tokyo Institute of Technology
kn-affil=

affil-num=8
en-affil=Department of Biological Sciences, Graduate School of Science, the University of Tokyo
kn-affil=

affil-num=9
en-affil=Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=2
article-no=
start-page=rkae045
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240327
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ANCA-associated vasculitis with isolated splenomegaly as the initial organ presentation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KitamuraWataru
en-aut-sei=Kitamura
en-aut-mei=Wataru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KuratsuneMasatoshi
en-aut-sei=Kuratsune
en-aut-mei=Masatoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IsekiAkiko
en-aut-sei=Iseki
en-aut-mei=Akiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KuyamaShoichi
en-aut-sei=Kuyama
en-aut-mei=Shoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Nephrology, National Hospital Organization Iwakuni Clinical Center
kn-affil=

affil-num=3
en-affil=Department of Pathology, National Hospital Organization Iwakuni Clinical Center
kn-affil=

affil-num=4
en-affil=Department of Respiratory Medicine, National Hospital Organization Iwakuni Clinical Center
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=rbac088
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221102
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fabrication of initial trabecular bone-inspired three-dimensional structure with cell membrane nano fragments
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The extracellular matrix of trabecular bone has a large surface exposed to the bone marrow and plays important roles such as hematopoietic stem cell niche formation and maintenance. In vitro reproduction of trabecular bone microenvironment would be valuable not only for developing a functional scaffold for bone marrow tissue engineering but also for understanding its biological functions. Herein, we analyzed and reproduced the initial stages of trabecular bone formation in mouse femur epiphysis. We identified that the trabecular bone formation progressed through the following steps: (i) partial rupture of hypertrophic chondrocytes; (ii) calcospherite formation on cell membrane nano fragments (CNFs) derived from the ruptured cells; and (iii) calcospherite growth and fusion to form the initial three-dimensional (3D) structure of trabecular bones. For reproducing the initial trabecular bone formation in vitro, we collected CNFs from cultured cells and used as nucleation sites for biomimetic calcospherite formation. Strikingly, almost the same 3D structure of the initial trabecular bone could be obtained in vitro by using additional CNFs as a binder to fuse biomimetic calcospherites.
en-copyright=
kn-copyright=

en-aut-name=KadoyaKoichi
en-aut-sei=Kadoya
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HaraEmilio Satoshi
en-aut-sei=Hara
en-aut-mei=Emilio Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkadaMasahiro
en-aut-sei=Okada
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=JiaoYu Yang
en-aut-sei=Jiao
en-aut-mei=Yu Yang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakanoTakayoshi
en-aut-sei=Nakano
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsumotoTakuya
en-aut-sei=Matsumoto
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Division of Materials & Manufacturing Science, Osaka University
kn-affil=

affil-num=6
en-affil=Department of Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=trabecular bone
kn-keyword=trabecular bone
en-keyword=calcospherites
kn-keyword=calcospherites
en-keyword=cell membrane nano fragments
kn-keyword=cell membrane nano fragments
en-keyword=three dimensionalization
kn-keyword=three dimensionalization
en-keyword=bone tissue synthesis
kn-keyword=bone tissue synthesis
END

start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=1
article-no=
start-page=dsad027
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20231222
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=MCPtaggR: R package for accurate genotype calling in reduced representation sequencing data by eliminating error-prone markers based on genome comparison
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Reduced representation sequencing (RRS) offers cost-effective, high-throughput genotyping platforms such as genotyping-by-sequencing (GBS). RRS reads are typically mapped onto a reference genome. However, mapping reads harbouring mismatches against the reference can potentially result in mismapping and biased mapping, leading to the detection of error-prone markers that provide incorrect genotype information. We established a genotype-calling pipeline named mappable collinear polymorphic tag genotyping (MCPtagg) to achieve accurate genotyping by eliminating error-prone markers. MCPtagg was designed for the RRS-based genotyping of a population derived from a biparental cross. The MCPtagg pipeline filters out error-prone markers prior to genotype calling based on marker collinearity information obtained by comparing the genome sequences of the parents of a population to be genotyped. A performance evaluation on real GBS data from a rice F2 population confirmed its effectiveness. Furthermore, our performance test using a genome assembly that was obtained by genome sequence polishing on an available genome assembly suggests that our pipeline performs well with converted genomes, rather than necessitating de novo assembly. This demonstrates its flexibility and scalability. The R package, MCPtaggR, was developed to provide functions for the pipeline and is available at https://github.com/tomoyukif/MCPtaggR.
en-copyright=
kn-copyright=

en-aut-name=FurutaTomoyuki
en-aut-sei=Furuta
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoToshio
en-aut-sei=Yamamoto
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=genotyping
kn-keyword=genotyping
en-keyword=genome comparison
kn-keyword=genome comparison
en-keyword=next-generation sequencing
kn-keyword=next-generation sequencing
en-keyword=R package
kn-keyword=R package
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=1
article-no=
start-page=zrad161
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240118
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Epidural versus patient-controlled intravenous analgesia on pain relief and recovery after laparoscopic gastrectomy for gastric cancer: randomized clinical trial
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Epidural analgesia (EDA) is a main modality for postoperative pain relief in major open abdominal surgery within the Enhanced Recovery After Surgery protocol. However, it remains unclear whether EDA is an imperative modality in laparoscopic gastrectomy (LG). This study examined non-inferiority of patient-controlled intravenous analgesia (PCIA) to EDA in terms of postoperative pain and recovery in patients who underwent LG. <br>
Methods: In this open-label, non-inferiority, parallel, individually randomized clinical trial, patients who underwent elective LG for gastric cancer were randomized 1:1 to receive either EDA or PCIA after surgery. The primary endpoint was pain score using the Numerical Rating Scale at rest 24 h after surgery, analysed both according to the intention-to-treat (ITT) principle and per protocol. The non-inferiority margin for pain score was set at 1. Secondary outcomes were postoperative parameters related to recovery and adverse events related to analgesia. <br>
Results: Between 3 July 2017 and 29 September 2020, 132 patients were randomized to receive either EDA (n = 66) or PCIA (n = 66). After exclusions, 64 patients were included in the EDA group and 65 patients in the PCIA group for the ITT analysis. Pain score at rest 24 h after surgery was 1.94 (s.d. 2.07) in the EDA group and 2.63 (s.d. 1.76) in the PCIA group (P = 0.043). PCIA was not non-inferior to EDA for the primary endpoint (difference 0.69, one side 95% c.i. 1.25, P = 0.184) in ITT analysis. Postoperative parameters related to recovery were similar between groups. More EDA patients (21 (32.8%) versus 1 (1.5%), P < 0.001) developed postoperative hypotension as an adverse event.<br>
Conclusions: PCIA was not non-inferior to EDA in terms of early-phase pain relief after LG. Registration number: UMIN000027643 (https://www.umin.ac.jp/ctr/index-j.htm). Conclusions: PCIA was not non-inferior to EDA in terms of early-phase pain relief after LG.Registration number: UMIN000027643 (https://www.umin.ac.jp/ctr/index-j.htm).
en-copyright=
kn-copyright=

en-aut-name=KikuchiSatoru
en-aut-sei=Kikuchi
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsusakiTakashi
en-aut-sei=Matsusaki
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KurodaShinji
en-aut-sei=Kuroda
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KashimaHajime
en-aut-sei=Kashima
en-aut-mei=Hajime
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakataNobuo
en-aut-sei=Takata
en-aut-mei=Nobuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MitsuiEma
en-aut-sei=Mitsui
en-aut-mei=Ema
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KakiuchiYoshihiko
en-aut-sei=Kakiuchi
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NomaKazuhiro
en-aut-sei=Noma
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=UmedaYuzo
en-aut-sei=Umeda
en-aut-mei=Yuzo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=5
article-no=
start-page=dsad015
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230616
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genetic basis of lineage-specific evolution of fruit traits in hexaploid persimmon
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Frequent polyploidization events in plants have led to the establishment of many lineage-specific traits representing each species. Little is known about the genetic bases for these specific traits in polyploids, presumably due to plant genomic complexity and their difficulties in applying genetic approaches. Hexaploid Oriental persimmon (Diospyros kaki) has evolved specific fruit characteristics, including wide variations in fruit shapes and astringency. In this study, using whole-genome diploidized/quantitative genotypes from ddRAD-Seq data of 173 persimmon cultivars, we examined their population structures and potential correlations between their structural transitions and variations in nine fruit traits. The population structures of persimmon cultivars were highly randomized and not substantially correlated with the representative fruit traits focused on in this study, except for fruit astringency. With genome-wide association analytic tools considering polyploid alleles, we identified the loci associated with the nine fruit traits; we mainly focused on fruit-shape variations, which have been numerically characterized by principal component analysis of elliptic Fourier descriptors. The genomic regions that putatively underwent selective sweep exhibited no overlap with the loci associated with these persimmon-specific fruit traits. These insights will contribute to understanding the genetic mechanisms by which fruit traits are independently established, possibly due to polyploidization events.
en-copyright=
kn-copyright=

en-aut-name=HoriuchiAyano
en-aut-sei=Horiuchi
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MasudaKanae
en-aut-sei=Masuda
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShirasawaKenta
en-aut-sei=Shirasawa
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoueNoriyuki
en-aut-sei=Onoue
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsuzakiRyusuke
en-aut-sei=Matsuzaki
en-aut-mei=Ryusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TaoRyutaro
en-aut-sei=Tao
en-aut-mei=Ryutaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KuboYasutaka
en-aut-sei=Kubo
en-aut-mei=Yasutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=UshijimaKoichiro
en-aut-sei=Ushijima
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AkagiTakashi
en-aut-sei=Akagi
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Kazusa DNA Research Institute
kn-affil=

affil-num=4
en-affil=Institute of Fruit Tree and Tea Science, NARO
kn-affil=

affil-num=5
en-affil=Institute of Fruit Tree and Tea Science, NARO
kn-affil=

affil-num=6
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=fruit shape
kn-keyword=fruit shape
en-keyword=astringency
kn-keyword=astringency
en-keyword=polyploid
kn-keyword=polyploid
en-keyword=population structure
kn-keyword=population structure
en-keyword=GWAS
kn-keyword=GWAS
END

start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=7
article-no=
start-page=msad151
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230707
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Ongoing Rapid Evolution of a Post-Y Region Revealed by Chromosome-Scale Genome Assembly of a Hexaploid Monoecious Persimmon (Diospyros kaki)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Plants have evolved sex chromosomes independently in many lineages, and loss of separate sexes can also occur. In this study, we assembled a monoecious recently hexaploidized persimmon (Diospyros kaki), in which the Y chromosome has lost the maleness-determining function. Comparative genomic analysis of D. kaki and its dioecious relatives uncovered the evolutionary process by which the nonfunctional Y chromosome (or Y-monoecy) was derived, which involved silencing of the sex-determining gene, OGI, approximately 2 million years ago. Analyses of the entire X and Y-monoecy chromosomes suggested that D. kaki's nonfunctional male-specific region of the Y chromosome (MSY), which we call a post-MSY, has conserved some characteristics of the original functional MSY. Specifically, comparing the functional MSY in Diospyros lotus and the nonfunctional "post-MSY" in D. kaki indicated that both have been rapidly rearranged, mainly via ongoing transposable element bursts, resembling structural changes often detected in Y-linked regions, some of which can enlarge the nonrecombining regions. The recent evolution of the post-MSY (and possibly also MSYs in dioecious Diospyros species) therefore probably reflects these regions' ancestral location in a pericentromeric region, rather than the presence of male-determining genes and/or genes controlling sexually dimorphic traits.
en-copyright=
kn-copyright=

en-aut-name=HoriuchiAyano
en-aut-sei=Horiuchi
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MasudaKanae
en-aut-sei=Masuda
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShirasawaKenta
en-aut-sei=Shirasawa
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoueNoriyuki
en-aut-sei=Onoue
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujitaNaoko
en-aut-sei=Fujita
en-aut-mei=Naoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=UshijimaKoichiro
en-aut-sei=Ushijima
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=AkagiTakashi
en-aut-sei=Akagi
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Frontier Research and Development, Kazusa DNA Research Institute
kn-affil=

affil-num=4
en-affil=Institute of Fruit Tree and Tea Science, NARO
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=sex chromosome
kn-keyword=sex chromosome
en-keyword=genome assembly
kn-keyword=genome assembly
en-keyword=monoecy
kn-keyword=monoecy
en-keyword=transposable elements
kn-keyword=transposable elements
END

start-ver=1.4
cd-journal=joma
no-vol=2023
cd-vols=
no-issue=6
article-no=
start-page=063H01
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Angular correlation of the two gamma rays produced in the thermal neutron capture on gadolinium-155 and gadolinium-157
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The ANNRI-Gd collaboration studied in detail the single gamma-ray spectrum produced from the thermal neutron capture on Gd-155 and Gd-157 in our previous publications. Gadolinium targets were exposed to a neutron beam provided by the Japan Spallation Neutron Source (JSNS) in J-PARC, Japan. In the present analysis, one new additional coaxial germanium crystal was used in combination with the 14 germanium crystals in the cluster detectors to study the angular correlation of the two gamma rays emitted in the same neutron capture. We present for the first time angular correlation functions for two gamma rays produced during the electromagnetic cascade transitions in the (n, gamma) reactions on Gd-155 and Gd-157. As expected, we observe mild angular correlations for the strong, but rare transitions from the resonance state to the two energy levels of known spin-parities. Contrariwise, we observe negligibly small angular correlations for arbitrary pairs of two gamma rays produced in the majority of cascade transitions from the resonance state to the dense continuum states.
en-copyright=
kn-copyright=

en-aut-name=GouxPierre
en-aut-sei=Goux
en-aut-mei=Pierre
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=GlessgenFranz
en-aut-sei=Glessgen
en-aut-mei=Franz
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=GazzolaEnrico
en-aut-sei=Gazzola
en-aut-mei=Enrico
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ReenMandeep Singh
en-aut-sei=Reen
en-aut-mei=Mandeep Singh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FocillonWilliam
en-aut-sei=Focillon
en-aut-mei=William
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=GoninMichel
en-aut-sei=Gonin
en-aut-mei=Michel
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TanakaTomoyuki
en-aut-sei=Tanaka
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HagiwaraKaito
en-aut-sei=Hagiwara
en-aut-mei=Kaito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AliAjmi
en-aut-sei=Ali
en-aut-mei=Ajmi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SudoTakashi
en-aut-sei=Sudo
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KoshioYusuke
en-aut-sei=Koshio
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SakudaMakoto
en-aut-sei=Sakuda
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=CollazuolGianmaria
en-aut-sei=Collazuol
en-aut-mei=Gianmaria
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KimuraAtsushi
en-aut-sei=Kimura
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=NakamuraShoji
en-aut-sei=Nakamura
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=IwamotoNobuyuki
en-aut-sei=Iwamoto
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=HaradaHideo
en-aut-sei=Harada
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=WurmMichael
en-aut-sei=Wurm
en-aut-mei=Michael
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

affil-num=1
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=5
en-affil=Département de Physique, École Polytechnique, IN2P3/CNRS
kn-affil=

affil-num=6
en-affil=Département de Physique, École Polytechnique, IN2P3/CNRS
kn-affil=

affil-num=7
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=13
en-affil=INFN Sezione di Padova and Università di Padova, Dipartimento di Fisica
kn-affil=

affil-num=14
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=15
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=16
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=17
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=18
en-affil=Institut für Physik, Johannes Gutenberg-Universität Mainz
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=5
article-no=
start-page=ytad214
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A successful bridge to recovery with Impella 5.0 and subsequent hybrid cardiac resynchronization therapy in systemic right ventricle failure: a case report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background　Impella 5.0 is currently used as a temporary mechanical circulatory support device in cardiogenic shock (CS). However, Impella 5.0 implantation for the systemic right ventricle (sRV) has not been well documented. <br>
Case summary　A 50-year-old man with atrial switch for dextro-transposition of the great arteries was transferred to our hospital for the treatment of embolic acute myocardial infarction of the left main trunk lesion with CS. To stabilize haemodynamics, we implanted Impella 5.0 via the left subclavian artery in the sRV. After optimal medical therapy initiation and gradual weaning of Impella 5.0, Impella 5.0 was successfully explanted. An electrocardiogram was obtained, which showed complete right branch block with a QRS duration of 172 ms. Acute invasive haemodynamic evaluation of cardiac resynchronization therapy (CRT) pacing showed that dP/dt increased from 497 to 605 mmHg/s (21.7% improvement), and hybrid cardiac resynchronization therapy defibrillator (CRTD) with a sRV epicardial lead was subsequently implanted. The patient was discharged without inotropic support. <br>
Discussion　Coronary artery embolism is a rare but serious complication of dextro-transposition of the great arteries after atrial switch operations. Impella 5.0 implantation is a feasible bridge strategy for refractory CS due to sRV failure. Although CRT implantation in patients with sRV is controversial, an acute invasive haemodynamic evaluation can help assess its potential benefits.
en-copyright=
kn-copyright=

en-aut-name=IwasakiKeiichiro
en-aut-sei=Iwasaki
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishiiNobuhiro
en-aut-sei=Nishii
en-aut-mei=Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AkagiSatoshi
en-aut-sei=Akagi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Transposition of great arteries
kn-keyword=Transposition of great arteries
en-keyword=Impella
kn-keyword=Impella
en-keyword=Mechanical circulatory support
kn-keyword=Mechanical circulatory support
en-keyword=Cardiac resynchronization therapy
kn-keyword=Cardiac resynchronization therapy
en-keyword=Case report
kn-keyword=Case report
END

start-ver=1.4
cd-journal=joma
no-vol=2023
cd-vols=
no-issue=1
article-no=
start-page=013D02
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Detection of the 4.4-MeV gamma rays from 16O(ν, ν′)16O(12.97 MeV, 2−) with a water Cherenkov detector in supernova neutrino bursts 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We first discuss and determine the isospin mixing of the two 2− states (12.53 MeV and 12.97 MeV) of the16O nucleus using inelastic electron scattering data. We then evaluate the cross section of 4.4-MeV γ rays produced in the neutrino neutral-current (NC) reaction 16O(ν, ν′)16O(12.97 MeV, 2−) in a water Cherenkov detector at a low energy, below 100 MeV. The detection of γ rays for Eγ > 5 MeV from the NC reaction 16O(ν, ν′)16O(Ex > 16 MeV, T = 1) with a water Cherenkov detector in supernova neutrino bursts has been proposed and discussed by several authors previously. In this article, we discuss a new NC reaction channel from 16O(12.97 MeV, 2−) producing a 4.4-MeV γ ray, the cross section of which is more robust and even larger at low energy (Eν < 25 MeV) than the NC cross section from 16O(Ex > 16 MeV, T = 1). We also evaluate the number of such events induced by neutrinos from supernova explosion which can be observed by the Super-Kamiokande, an Earth-based 32-kton water Cherenkov detector.
en-copyright=
kn-copyright=

en-aut-name=SakudaMakoto
en-aut-sei=Sakuda
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SuzukiToshio
en-aut-sei=Suzuki
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ReenMandeep Singh
en-aut-sei=Reen
en-aut-mei=Mandeep Singh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakazatoKen'Ichiro
en-aut-sei=Nakazato
en-aut-mei=Ken'Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SuzukiHideyuki
en-aut-sei=Suzuki
en-aut-mei=Hideyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Physics Department, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Physics, College of Humanities and Sciences, Nihon University
kn-affil=

affil-num=3
en-affil=Department of Physics, Akal University
kn-affil=

affil-num=4
en-affil=Faculty of Arts and Science, Kyushu University
kn-affil=

affil-num=5
en-affil=Department of Physics, Faculty of Science and Technology, Tokyo University of Science
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=4
article-no=
start-page=igac035
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220606
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Effects of Wages and Training on Intent to Switch or Leave Among Direct Care Workers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background and Objectives Although most studies have not separated turnover of direct care workers (DCWs) into those who switch to another organization (switchers) and those who leave the industry (leavers), switchers and leavers have different impacts on the facilities they quit and the labor market for DCWs. We distinguished between intent to switch and intent to leave and investigated the impact of wages and training on each turnover intention. Research Design and Methods Data were obtained from Japan's Fact-Finding Survey on Long-term Care Work. We included DCWs (n = 7,311) in the analyses and used multinomial regression by sex and provider type to compare those who wanted to switch and those who wanted to leave with those who wanted to remain in their current workplace. Results The impacts of an increase in wages and a higher training score were larger for intent to switch than intent to leave. Compared with wages, the impact of training was greater. The impact of job characteristics on turnover intention varied between women and men and across provider types. Discussion and Implications This study provides a better understanding of the difference in the determinants of switching and leaving and simultaneously increases our understanding of the differences between women and men and across provider types.
en-copyright=
kn-copyright=

en-aut-name=KishidaKensaku
en-aut-sei=Kishida
en-aut-mei=Kensaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=
en-keyword=Long-term care
kn-keyword=Long-term care
en-keyword=Turnover
kn-keyword=Turnover
en-keyword=Workforce issues
kn-keyword=Workforce issues
END

start-ver=1.4
cd-journal=joma
no-vol=34
cd-vols=
no-issue=11
article-no=
start-page=563
end-page=570
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=2022423
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A variety of ‘exhausted’ T cells in the tumor microenvironment
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In T-cell biology, ‘exhaustion’ was initially described as a hyporesponsive state in CD8+ T cells during chronic infections. Recently, exhaustion has been recognized as a T-cell dysfunctional state in the tumor microenvironment (TME). The term ‘exhaustion’ is used mainly to refer to effector T cells with a reduced capacity to secrete cytokines and an increased expression of inhibitory receptors. The up-regulation of exhaustion-related inhibitory receptors, including programmed cell death protein 1 (PD-1), in such T cells has been associated with the development of tumors, prompting the development of immune checkpoint inhibitors. In addition to CD8+ T cells, CD4+ T cells, including the regulatory T (Treg) cell subset, perform a wide variety of functions within the adaptive immune system. Up-regulation of the same inhibitory receptors that are associated with CD8+ T-cell exhaustion has also been identified in CD4+ T cells in chronic infections and cancers, suggesting a similar CD4+ T-cell exhaustion phenotype. For instance, high expression of PD-1 has been observed in Treg cells in the TME, and such Treg cells can play an important role in the resistance to PD-1 blockade therapies. Furthermore, recent progress in single-cell RNA sequencing has shown that CD4+ T cells with cytotoxic activity are also vulnerable to exhaustion. In this review, we will discuss novel insights into various exhausted T-cell subsets, which could reveal novel therapeutic targets and strategies to induce a robust anti-tumor immune response.
en-copyright=
kn-copyright=

en-aut-name=NagasakiJoji
en-aut-sei=Nagasaki
en-aut-mei=Joji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TogashiYosuke
en-aut-sei=Togashi
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Tumor Microenvironment, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Tumor Microenvironment, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=CD4(+) T cell
kn-keyword=CD4(+) T cell
en-keyword=cytotoxic CD4(+ )T cell
kn-keyword=cytotoxic CD4(+ )T cell
en-keyword=regulatory T cell
kn-keyword=regulatory T cell
en-keyword=T-cell exhaustion
kn-keyword=T-cell exhaustion
END

start-ver=1.4
cd-journal=joma
no-vol=2022
cd-vols=
no-issue=5
article-no=
start-page=rjac101
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220501
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Anorectal leiomyoma with GLUT1 overexpression mimicking malignancy on FDG-PET/CT
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 43-year-old female underwent pelvic magnetic resonance imaging for uterine myoma that incidentally revealed a 4.6 x 2.8 cm soft tissue mass in the anorectal region. Rectal endoscopy showed a submucosal tumor just above the anal canal. Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) revealed an anorectal tumor with very high FDG uptake. Aspiration cytology and needle biopsy were inconclusive, and the patient underwent trans-perineal tumor resection. The excised tumor was a 4.6 x 3.5 x 2.7 cm gray-white bifurcated nodular tumor. Light microscopy revealed fenestrated growth of poorly dysmorphic short spindle-shaped cells with eosinophilic sporophytes. Immunohistochemical staining was positive for alpha SMA and desmin, negative for CD117 (KIT) and S100, and the patient was diagnosed with benign leiomyoma. Tumor cells were also positive for glucose transporter-1 (GLUT1) immunohistochemically. It is important to keep in mind that FDG-PET/CT may show false-positive results even in benign anal leiomyoma for various reasons, including GLUT1 overexpression.
en-copyright=
kn-copyright=

en-aut-name=TeraishiFuminori
en-aut-sei=Teraishi
en-aut-mei=Fuminori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShigeyasuKunitoshi
en-aut-sei=Shigeyasu
en-aut-mei=Kunitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=29
cd-vols=
no-issue=1
article-no=
start-page=dsac001
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Chromosome-scale assembly of barley cv. 'Haruna Nijo' as a resource for barley genetics
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cultivated barley (Hordeum vulgare ssp. vulgare) is used for food, animal feed, and alcoholic beverages and is widely grown in temperate regions. Both barley and its wild progenitor (H. vulgare ssp. spontaneum) have large 5.1-Gb genomes. High-quality chromosome-scale assemblies for several representative barley genotypes, both wild and domesticated, have been constructed recently to populate the nascent barley pan-genome infrastructure. Here, we release a chromosome-scale assembly of the Japanese elite malting barley cultivar 'Haruna Nijo' using a similar methodology as in the barley pan-genome project. The 4.28-Gb assembly had a scaffold N50 size of 18.9 Mb. The assembly showed high collinearity with the barley reference genome 'Morex' cultivar, with some inversions. The pseudomolecule assembly was characterized using transcript evidence of gene projection derived from the reference genome and de novo gene annotation achieved using published full-length cDNA sequences and RNA-Seq data for 'Haruna Nijo'. We found good concordance between our whole-genome assembly and the publicly available BAC clone sequence of 'Haruna Nijo'. Interesting phenotypes have since been identified in Haruna Nijo; its genome sequence assembly will facilitate the identification of the underlying genes.
en-copyright=
kn-copyright=

en-aut-name=SakkourAreej
en-aut-sei=Sakkour
en-aut-mei=Areej
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MascherMartin
en-aut-sei=Mascher
en-aut-mei=Martin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HimmelbachAxel
en-aut-sei=Himmelbach
en-aut-mei=Axel
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HabererGeorg
en-aut-sei=Haberer
en-aut-mei=Georg
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=LuxThomas
en-aut-sei=Lux
en-aut-mei=Thomas
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SpannaglManuel
en-aut-sei=Spannagl
en-aut-mei=Manuel
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SteinNils
en-aut-sei=Stein
en-aut-mei=Nils
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KawamotoShoko
en-aut-sei=Kawamoto
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SatoKazuhiro
en-aut-sei=Sato
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Department Genebank, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK)
kn-affil=

affil-num=3
en-affil=Department Genebank, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK)
kn-affil=

affil-num=4
en-affil=Plant Genome and Systems Biology (PGSB), Helmholtz Center Munich, German Research Center for Environmental Health
kn-affil=

affil-num=5
en-affil=Plant Genome and Systems Biology (PGSB), Helmholtz Center Munich, German Research Center for Environmental Health
kn-affil=

affil-num=6
en-affil=Plant Genome and Systems Biology (PGSB), Helmholtz Center Munich, German Research Center for Environmental Health
kn-affil=

affil-num=7
en-affil=Department Genebank, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK)
kn-affil=

affil-num=8
en-affil=Department of Informatics, National Institute of Genetics
kn-affil=

affil-num=9
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=Hordeum vulgare
kn-keyword=Hordeum vulgare
en-keyword=full-length cDNA
kn-keyword=full-length cDNA
en-keyword=RNA-Seq
kn-keyword=RNA-Seq
en-keyword=genome sequencing
kn-keyword=genome sequencing
en-keyword=pseudomolecules
kn-keyword=pseudomolecules
END

start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=5
article-no=
start-page=861
end-page=867
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210809
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m(3) (for one, three, or 10 days). The 8-hydroxy-2 '-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m(3) radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m(3) radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20-40% (2 kBq/m(3) for three days or 20 kBq/m(3) for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15-60% and 15-45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.
en-copyright=
kn-copyright=

en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShutoHina
en-aut-sei=Shuto
en-aut-mei=Hina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YanoJunki
en-aut-sei=Yano
en-aut-mei=Junki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KanzakiNorie
en-aut-sei=Kanzaki
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TanakaHiroshi
en-aut-sei=Tanaka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TeratoHiroaki
en-aut-sei=Terato
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=

affil-num=6
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=

affil-num=7
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=

affil-num=8
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School ofMedicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Advanced Science Research Center Okayama University
kn-affil=

affil-num=11
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=radon
kn-keyword=radon
en-keyword=oxidative DNA damage
kn-keyword=oxidative DNA damage
en-keyword=Mn-superoxide dismutase (SOD)
kn-keyword=Mn-superoxide dismutase (SOD)
en-keyword=8-oxoguanine DNA glycosylase
kn-keyword=8-oxoguanine DNA glycosylase
END

start-ver=1.4
cd-journal=joma
no-vol=51
cd-vols=
no-issue=1
article-no=
start-page=130
end-page=137
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=2020727
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Long-term ureteroscopic management of upper tract urothelial carcinoma: 28-year single-centre experience
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background</br>
Long-term survival outcomes of patients who undergo endoscopic management of non-invasive upper tract urothelial carcinoma remain uncertain. The longest mean follow-up period in previous studies was 6.1 years. This study reports the long-term outcomes of patients with upper tract urothelial carcinoma who underwent ureteroscopic ablation at a single institution over a 28-year period.</br>
Methods</br>
We identified all patients who underwent ureteroscopic management of upper tract urothelial carcinoma as their primary treatment at our institution between January 1991 and April 2011. Survival outcomes, including overall survival, cancer-specific survival, upper-tract recurrence-free survival and renal unit survival, were estimated using Kaplan−Meier methodology.</br>
Results</br>
A total of 15 patients underwent endoscopic management, with a mean age at diagnosis of 66 years. All patients underwent ureteroscopy, and biopsy-confirmed pathology was obtained. Median (range; mean) follow-up was 11.7 (2.3–20.9, 11.9) years. Upper tract recurrence occurred in 87% (n = 13) of patients. Twenty percent (n = 3) of patients proceeded to nephroureterectomy. The estimated cancer-specific survival rate was 93% at 5, 10, 15 and 20 years. Estimated overall survival rates were 86, 80, 54 and 20% at 5, 10, 15 and 20 years. Only one patient experienced cancer-specific mortality. The estimated mean and median overall survival times were 14.5 and 16.6 years, respectively. The estimated mean cancer-specific survival time was not reached.</br>
Conclusions</br>
Although upper tract recurrence is common, endoscopic management of non-invasive upper tract urothelial carcinoma provides a 90% cancer-specific survival rate at 20 years in selected patients.
en-copyright=
kn-copyright=

en-aut-name=MaruyamaYuki
en-aut-sei=Maruyama
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ArakiMotoo
en-aut-sei=Araki
en-aut-mei=Motoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WadaKoichiro
en-aut-sei=Wada
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YoshinagaKasumi
en-aut-sei=Yoshinaga
en-aut-mei=Kasumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MitsuiYosuke
en-aut-sei=Mitsui
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SadahiraTakuya
en-aut-sei=Sadahira
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NishimuraShingo
en-aut-sei=Nishimura
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=EdamuraKohei
en-aut-sei=Edamura
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KobayashiYasuyuki
en-aut-sei=Kobayashi
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=WatanabeMasami
en-aut-sei=Watanabe
en-aut-mei=Masami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=WatanabeToyohiko
en-aut-sei=Watanabe
en-aut-mei=Toyohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MongaManoj
en-aut-sei=Monga
en-aut-mei=Manoj
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=NasuYasutomo
en-aut-sei=Nasu
en-aut-mei=Yasutomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KumonHiromi
en-aut-sei=Kumon
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=2
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=3
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=4
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=5
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=6
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=7
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=8
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=9
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=10
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=11
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=12
en-affil=Department of Urology, The Cleveland Clinic
kn-affil=

affil-num=13
en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science
kn-affil=

affil-num=14
en-affil=Innovation Center Okayama for Nanobio-Targeted Therapy, Okayama University
kn-affil=
en-keyword=urothelial carcinoma
kn-keyword=urothelial carcinoma
en-keyword=urinary tract cancer
kn-keyword=urinary tract cancer
en-keyword=ureteroscopy
kn-keyword=ureteroscopy
en-keyword=long-term survival
kn-keyword=long-term survival
en-keyword=renal pelvis
kn-keyword=renal pelvis
en-keyword=ureter
kn-keyword=ureter
END

start-ver=1.4
cd-journal=joma
no-vol=27
cd-vols=
no-issue=4
article-no=
start-page=dsaa023
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200926
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=History and future perspectives of barley genomics
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Barley (Hordeum vulgare), one of the most widely cultivated cereal crops, possesses a large genome of 5.1Gbp. Through various international collaborations, the genome has recently been sequenced and assembled at the chromosome-scale by exploiting available genetic and genomic resources. Many wild and cultivated barley accessions have been collected and preserved around the world. These accessions are crucial to obtain diverse natural and induced barley variants. The barley bioresource project aims to investigate the diversity of this crop based on purified seed and DNA samples of a large number of collected accessions. The long-term goal of this project is to analyse the genome sequences of major barley accessions worldwide. In view of technical limitations, a strategy has been employed to establish the exome structure of a selected number of accessions and to perform high-quality chromosome-scale assembly of the genomes of several major representative accessions. For the future project, an efficient annotation pipeline is essential for establishing the function of genomes and genes as well as for using this information for sequence-based digital barley breeding. In this article, the author reviews the existing barley resources along with their applications and discuss possible future directions of research in barley genomics.
en-copyright=
kn-copyright=

en-aut-name=SatoKazuhiro
en-aut-sei=Sato
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=Hordeum vulgare
kn-keyword=Hordeum vulgare
en-keyword=genome sequencing
kn-keyword=genome sequencing
en-keyword=genetic resources
kn-keyword=genetic resources
END

start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=8
article-no=
start-page=1408
end-page=1418
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200511
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Decoding Plant–Environment Interactions That Influence Crop Agronomic Traits
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To ensure food security in the face of increasing global demand due to population growth and progressive urbanization, it will be crucial to integrate emerging technologies in multiple disciplines to accelerate overall throughput of gene discovery and crop breeding. Plant agronomic traits often appear during the plants’ later growth stages due to the cumulative effects of their lifetime interactions with the environment. Therefore, decoding plant–environment interactions by elucidating plants’ temporal physiological responses to environmental changes throughout their lifespans will facilitate the identification of genetic and environmental factors, timing and pathways that influence complex end-point agronomic traits, such as yield. Here, we discuss the expected role of the life-course approach to monitoring plant and crop health status in improving crop productivity by enhancing the understanding of plant–environment interactions. We review recent advances in analytical technologies for monitoring health status in plants based on multi-omics analyses and strategies for integrating heterogeneous datasets from multiple omics areas to identify informative factors associated with traits of interest. In addition, we showcase emerging phenomics techniques that enable the noninvasive and continuous monitoring of plant growth by various means, including three-dimensional phenotyping, plant root phenotyping, implantable/injectable sensors and affordable phenotyping devices. Finally, we present an integrated review of analytical technologies and applications for monitoring plant growth, developed across disciplines, such as plant science, data science and sensors and Internet-of-things technologies, to improve plant productivity.
en-copyright=
kn-copyright=

en-aut-name=MochidaKeiichi
en-aut-sei=Mochida
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishiiRyuei
en-aut-sei=Nishii
en-aut-mei=Ryuei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HirayamaTakashi
en-aut-sei=Hirayama
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=School of Information and Data Sciences, Nagasaki University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=Genome to phenome
kn-keyword=Genome to phenome
en-keyword=Life-course approach
kn-keyword=Life-course approach
en-keyword=Multi-omics
kn-keyword=Multi-omics
en-keyword=Plant phenomics
kn-keyword=Plant phenomics
en-keyword=Sensor.
kn-keyword=Sensor.
END

start-ver=1.4
cd-journal=joma
no-vol=2020
cd-vols=
no-issue=9
article-no=
start-page=093H02
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200920
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Improved method for measuring low-concentration radium and its application to the Super-Kamiokande Gadolinium project
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Chemical extraction using a molecular recognition resin named "Empore Radium Rad Disk" was developed to improve sensitivity for the low concentration of radium (Ra). Compared with the previous method, the extraction process speed was improved by a factor of three and the recovery rate for Ra-226 was also improved from 81 +/- 4% to > 99.9%. The sensitivity on the 10(-1) mBq level was achieved using a high-purity germanium detector. This improved method was applied to determine Ra-226 in Gd-2(SO4)(3)center dot 8H(2)O which will be used in the Super-Kamiokande Gadolinium project. The improvement and measurement results are reported in this paper.
en-copyright=
kn-copyright=

en-aut-name=ItoS.
en-aut-sei=Ito
en-aut-mei=S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IchimuraK.
en-aut-sei=Ichimura
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakakuY.
en-aut-sei=Takaku
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AbeK.
en-aut-sei=Abe
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HaradaM.
en-aut-sei=Harada
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IkedaM.
en-aut-sei=Ikeda
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ItoH.
en-aut-sei=Ito
en-aut-mei=H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KishimotoY.
en-aut-sei=Kishimoto
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakajimaY.
en-aut-sei=Nakajima
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OkadaT.
en-aut-sei=Okada
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SekiyaH.
en-aut-sei=Sekiya
en-aut-mei=H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Okayama University, Faculty of Science
kn-affil=

affil-num=2
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=3
en-affil=Institute for Environmental Sciences, Department of Radioecology
kn-affil=

affil-num=4
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=5
en-affil=Okayama University, Faculty of Science
kn-affil=

affil-num=6
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=7
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=8
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=9
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=10
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=11
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=8
article-no=
start-page=1438
end-page=1448
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200415
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Life-Course Monitoring of Endogenous Phytohormone Levels under Field Conditions Reveals Diversity of Physiological States among Barley Accessions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Agronomically important traits often develop during the later stages of crop growth as consequences of various plant–environment interactions. Therefore, the temporal physiological states that change and accumulate during the crop’s life course can significantly affect the eventual phenotypic differences in agronomic traits among crop varieties. Thus, to improve productivity, it is important to elucidate the associations between temporal physiological responses during the growth of different crop varieties and their agronomic traits. However, data representing the dynamics and diversity of physiological states in plants grown under field conditions are sparse. In this study, we quantified the endogenous levels of five phytohormones — auxin, cytokinins (CKs), ABA, jasmonate and salicylic acid — in the leaves of eight diverse barley (Hordeum vulgare) accessions grown under field conditions sampled weekly over their life course to assess the ongoing fluctuations in hormone levels in the different accessions under field growth conditions. Notably, we observed enormous changes over time in the development-related plant hormones, such as auxin and CKs. Using 3′ RNA-seq-based transcriptome data from the same samples, we investigated the expression of barley genes orthologous to known hormone-related genes of Arabidopsis throughout the life course. These data illustrated the dynamics and diversity of the physiological states of these field-grown barley accessions. Together, our findings provide new insights into plant–environment interactions, highlighting that there is cultivar diversity in physiological responses during growth under field conditions.
en-copyright=
kn-copyright=

en-aut-name=HirayamaTakashi
en-aut-sei=Hirayama
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SaishoDaisuke
en-aut-sei=Saisho
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsuuraTakakazu
en-aut-sei=Matsuura
en-aut-mei=Takakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkadaSatoshi
en-aut-sei=Okada
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakahagiKotaro
en-aut-sei=Takahagi
en-aut-mei=Kotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KanataniAsaka
en-aut-sei=Kanatani
en-aut-mei=Asaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ItoJun
en-aut-sei=Ito
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TsujiHiroyuki
en-aut-sei=Tsuji
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IkedaYoko
en-aut-sei=Ikeda
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MochidaKeiichi
en-aut-sei=Mochida
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=5
en-affil=RIKEN Center for Sustainable Resource Science
kn-affil=

affil-num=6
en-affil=RIKEN Center for Sustainable Resource Science
kn-affil=

affil-num=7
en-affil=Kihara Institute for Biological Research, Yokohama City University
kn-affil=

affil-num=8
en-affil=Kihara Institute for Biological Research, Yokohama City University
kn-affil=

affil-num=9
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=10
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=transcriptome
kn-keyword=transcriptome
en-keyword=barley
kn-keyword=barley
en-keyword=filed conditions
kn-keyword=filed conditions
en-keyword=hormone profiling
kn-keyword=hormone profiling
en-keyword=life-course monitoring
kn-keyword=life-course monitoring
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=16
article-no=
start-page=4778
end-page=4796
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200506
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Low temperature modulates natural peel degreening in lemon fruit independently of endogenous ethylene
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Peel degreening is an important aspect of fruit ripening in many citrus fruit, and previous studies have shown that it can be advanced by ethylene treatment or by low-temperature storage. However, the important regulators and pathways involved in natural peel degreening remain largely unknown. To determine how natural peel degreening is regulated in lemon fruit (Citrus limon), we studied transcriptome and physiochemical changes in the flavedo in response to ethylene treatment and low temperatures. Treatment with ethylene induced rapid peel degreening, which was strongly inhibited by the ethylene antagonist, 1-methylcyclopropene (1-MCP). Compared with 25 degrees C, moderately low storage temperatures of 5-20 degrees C also triggered peel degreening. Surprisingly, repeated 1-MCP treatments failed to inhibit the peel degreening induced by low temperature. Transcriptome analysis revealed that low temperature and ethylene independently regulated genes associated with chlorophyll degradation, carotenoid metabolism, photosystem proteins, phytohormone biosynthesis and signalling, and transcription factors. Peel degreening of fruit on trees occurred in association with drops in ambient temperature, and it coincided with the differential expression of low temperature-regulated genes. In contrast, genes that were uniquely regulated by ethylene showed no significant expression changes during on-tree peel degreening. Based on these findings, we hypothesize that low temperature plays a prominent role in regulating natural peel degreening independently of ethylene in citrus fruit.
en-copyright=
kn-copyright=

en-aut-name=MitaloOscar W.
en-aut-sei=Mitalo
en-aut-mei=Oscar W.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OtsukiTakumi
en-aut-sei=Otsuki
en-aut-mei=Takumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkadaRui
en-aut-sei=Okada
en-aut-mei=Rui
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ObitsuSaeka
en-aut-sei=Obitsu
en-aut-mei=Saeka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MasudaKanae
en-aut-sei=Masuda
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HojoYuko
en-aut-sei=Hojo
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsuuraTakakazu
en-aut-sei=Matsuura
en-aut-mei=Takakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MoriIzumi C.
en-aut-sei=Mori
en-aut-mei=Izumi C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AbeDaigo
en-aut-sei=Abe
en-aut-mei=Daigo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=AsicheWilliam O.
en-aut-sei=Asiche
en-aut-mei=William O.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AkagiTakashi
en-aut-sei=Akagi
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KuboYasutaka
en-aut-sei=Kubo
en-aut-mei=Yasutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=UshijimaKoichiro
en-aut-sei=Ushijima
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=7
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=8
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=9
en-affil=National Agriculture and Food Research Organization, Shikoku Research Station
kn-affil=

affil-num=10
en-affil=Department of Research and Development, Del Monte Kenya Ltd
kn-affil=

affil-num=11
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=12
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=13
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=1-methylcyclopropene
kn-keyword=1-methylcyclopropene
en-keyword=carotenoids
kn-keyword=carotenoids
en-keyword=chlorophyll
kn-keyword=chlorophyll
en-keyword=Citrus limon
kn-keyword=Citrus limon
en-keyword=ethylene
kn-keyword=ethylene
en-keyword=low temperature
kn-keyword=low temperature
en-keyword=peel degreening
kn-keyword=peel degreening
en-keyword=phytohormones
kn-keyword=phytohormones
en-keyword=transcriptome
kn-keyword=transcriptome
END

start-ver=1.4
cd-journal=joma
no-vol=2020
cd-vols=
no-issue=4
article-no=
start-page=043D02
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200413
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Gamma-ray spectra from thermal neutron capture on gadolinium-155 and natural gadolinium
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Natural gadolinium is widely used for its excellent thermal neutron capture cross section, because of its two major isotopes: Gd-155 and Gd-157. We measured the gamma-ray spectra produced from the thermal neutron capture on targets comprising a natural gadolinium film and enriched Gd-155 (in Gd2O3 powder) in the energy range from 0.11 MeV to 8.0 MeV, using the ANNRI germanium spectrometer at MLF, J-PARC. The freshly analyzed data of the Gd-155(n,gamma) reaction are used to improve our previously developed model (ANNRI-Gd model) for the Gd-157(n,gamma) reaction [K. Hagiwara et al. [ANNRI-Gd Collaboration], Prog. Theor. Exp. Phys. 2019, 023D01 (2019)], and its performance confirmed with the independent data from the Gd-nat(n,gamma) reaction. This article completes the development of an efficient Monte Carlo model required to simulate and analyze particle interactions involving the thermal neutron captures on gadolinium in any relevant future experiments.
en-copyright=
kn-copyright=

en-aut-name=TanakaTomoyuki
en-aut-sei=Tanaka
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HagiwaraKaito
en-aut-sei=Hagiwara
en-aut-mei=Kaito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=GazzolaEnrico
en-aut-sei=Gazzola
en-aut-mei=Enrico
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AliAjmi
en-aut-sei=Ali
en-aut-mei=Ajmi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OuIwa
en-aut-sei=Ou
en-aut-mei=Iwa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SudoTakashi
en-aut-sei=Sudo
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=DasPretam Kumar
en-aut-sei=Das
en-aut-mei=Pretam Kumar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ReenMandeep Singh
en-aut-sei=Reen
en-aut-mei=Mandeep Singh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=DhirRohit
en-aut-sei=Dhir
en-aut-mei=Rohit
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KoshioYusuke
en-aut-sei=Koshio
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SakudaMakoto
en-aut-sei=Sakuda
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KimuraAtsushi
en-aut-sei=Kimura
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=NakamuraShoji
en-aut-sei=Nakamura
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=IwamotoNobuyuki
en-aut-sei=Iwamoto
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=HaradaHideo
en-aut-sei=Harada
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=CollazuolGianmaria
en-aut-sei=Collazuol
en-aut-mei=Gianmaria
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=LorenzSebastian
en-aut-sei=Lorenz
en-aut-mei=Sebastian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=WurmMichael
en-aut-sei=Wurm
en-aut-mei=Michael
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=FocillonWilliam
en-aut-sei=Focillon
en-aut-mei=William
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=GoninMichel
en-aut-sei=Gonin
en-aut-mei=Michel
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=YanoTakatomi
en-aut-sei=Yano
en-aut-mei=Takatomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

affil-num=1
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=3
en-affil=Universitá di Padova and INFN, Dipartimento di Fisica
kn-affil=

affil-num=4
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=12
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=13
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=14
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=15
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=16
en-affil=Universitá di Padova and INFN, Dipartimento di Fisica
kn-affil=

affil-num=17
en-affil=Institut für Physik, Johannes Gutenberg-Universität Mainz
kn-affil=

affil-num=18
en-affil=Institut für Physik, Johannes Gutenberg-Universität Mainz
kn-affil=

affil-num=19
en-affil=Département de Physique, École Polytechnique
kn-affil=

affil-num=20
en-affil=Département de Physique, École Polytechnique
kn-affil=

affil-num=21
en-affil=Kamioka Observatory, ICRR, University of Tokyo
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=10
article-no=
start-page=2922
end-page=2932
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibition of light-induced stomatal opening by allyl isothiocyanate does not require guard cell cytosolic Ca2+ signaling
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The glucosinolate-myrosinase system is a well-known defense system that has been shown to induce stomatal closure in Brassicales. Isothiocyanates are highly reactive hydrolysates of glucosinolates, and an isothiocyanate, allyl isothiocyanate (AITC), induces stomatal closure accompanied by elevation of free cytosolic Ca2+ concentration ([Ca2+](cyt)) in Arabidopsis. It remains unknown whether AITC inhibits light-induced stomatal opening. This study investigated the role of Ca2+ in AITC-induced stomatal closure and inhibition of light-induced stomatal opening. AITC induced stomatal closure and inhibited light-induced stomatal opening in a dose-dependent manner. A Ca2+ channel inhibitor, La3+, a Ca(2+)chelator, EGTA, and an inhibitor of Ca2+ release from internal stores, nicotinamide, inhibited AITC-induced [Ca2+](cyt) elevation and stomatal closure, but did not affect inhibition of light-induced stomatal opening. AITC activated non-selective Ca2+-permeable cation channels and inhibited inward-rectifying K+ (K-in(+)) channels in a Ca2+-independent manner. AITC also inhibited stomatal opening induced by fusicoccin, a plasma membrane H+-ATPase activator, but had no significant effect on fusicoccin-induced phosphorylation of the penultimate threonine of H+-ATPase. Taken together, these results suggest that AITC induces Ca2+ influx and Ca2+ release to elevate [Ca2+](cyt), which is essential for AITC-induced stomatal closure but not for inhibition of K-in(+) channels and light-induced stomatal opening.
en-copyright=
kn-copyright=

en-aut-name=YeWenxiu
en-aut-sei=Ye
en-aut-mei=Wenxiu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AndoEigo
en-aut-sei=Ando
en-aut-mei=Eigo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=RhamanMohammad Saidur
en-aut-sei=Rhaman
en-aut-mei=Mohammad Saidur
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Tahjib-Ul-ArifMd
en-aut-sei=Tahjib-Ul-Arif
en-aut-mei=Md
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OkumaEiji
en-aut-sei=Okuma
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KinoshitaToshinori
en-aut-sei=Kinoshita
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Science, Nagoya University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Institute of Transformative Bio-Molecule, Nagoya University
kn-affil=

affil-num=8
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Allyl isothiocyanate
kn-keyword=Allyl isothiocyanate
en-keyword=Arabidopsis
kn-keyword=Arabidopsis
en-keyword=calcium channel
kn-keyword=calcium channel
en-keyword=potassium channel
kn-keyword=potassium channel
en-keyword=proton pump
kn-keyword=proton pump
en-keyword=stomatal closure
kn-keyword=stomatal closure
en-keyword=stomatal opening
kn-keyword=stomatal opening
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=5
article-no=
start-page=1683
end-page=1696
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190502
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Honeydew-associated microbes elicit defense responses against brown planthopper in rice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Feeding of sucking insects, such as the rice brown planthopper (Nilaparvata lugens; BPH), causes only limited mechanical damage on plants that is otherwise essential for injury-triggered defense responses against herbivores. In pursuit of complementary BPH elicitors perceived by plants, we examined the potential effects of BPH honeydew secretions on the BPH monocot host, rice (Oryza sativa). We found that BPH honeydew strongly elicits direct and putative indirect defenses in rice, namely accumulation of phytoalexins in the leaves, and release of volatile organic compounds from the leaves that serve to attract natural enemies of herbivores, respectively. We then examined the elicitor active components in the honeydew and found that bacteria in the secretions are responsible for the activation of plant defense. Corroborating the importance of honeydew-associated microbiota for induced plant resistance, BPHs partially devoid of their microbiota via prolonged antibiotics ingestion induced significantly less defense in rice relative to antibiotic-free insects applied to similar groups of plants. Our data suggest that rice plants may additionally perceive herbivores via their honeydew-associated microbes, allowing them to discriminate between incompatible herbivores—that do not produce honeydew—and those that are compatible and therefore dangerous.
en-copyright=
kn-copyright=

en-aut-name=WariDavid
en-aut-sei=Wari
en-aut-mei=David
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KabirMd Alamgir
en-aut-sei=Kabir
en-aut-mei=Md Alamgir
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MujionoKadis
en-aut-sei=Mujiono
en-aut-mei=Kadis
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HojoYuko
en-aut-sei=Hojo
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ShinyaTomonori
en-aut-sei=Shinya
en-aut-mei=Tomonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TaniAkio
en-aut-sei=Tani
en-aut-mei=Akio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakataniHiroko
en-aut-sei=Nakatani
en-aut-mei=Hiroko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=GalisIvan
en-aut-sei=Galis
en-aut-mei=Ivan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=6
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=7
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=8
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=Honeydew-associated microorganisms
kn-keyword=Honeydew-associated microorganisms
en-keyword=phytoalexins
kn-keyword=phytoalexins
en-keyword=plant defense
kn-keyword=plant defense
en-keyword=rice (Oryza sativa)
kn-keyword=rice (Oryza sativa)
en-keyword=rice brown planthopper (Nilaparvata lugens)
kn-keyword=rice brown planthopper (Nilaparvata lugens)
en-keyword=sucking insect
kn-keyword=sucking insect
END

start-ver=1.4
cd-journal=joma
no-vol=130
cd-vols=
no-issue=1
article-no=
start-page=34
end-page=40
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200507
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genetic variation and phenotypic plasticity in circadian rhythms in an armed beetle, Gnatocerus cornutus (Tenebrionidae)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Circadian rhythms, their free-running periods and the power of the rhythms are often used as indicators of biological clocks, and there is evidence that the free-running periods of circadian rhythms are not affected by environmental factors, such as temperature. However, there are few studies of environmental effects on the power of the rhythms, and it is not clear whether temperature compensation is universal. Additionally, genetic variation and phenotypic plasticity in biological clocks are important for understanding the evolution of biological rhythms, but genetic and plastic effects are rarely investigated. Here, we used 18 isofemale lines (genotypes) of Gnatocerus cornutus to assess rhythms of locomotor activity, while also testing for temperature effects. We found that total activity and the power of the circadian rhythm were affected by interactions between sex and genotype or between sex, genotype and temperature. The males tended to be more active and showed greater increases in activity, but this effect varied across both genotypes and temperatures. The period of activity varied only by genotype and was thus independent of temperature. The complicated genotype–sex–environment interactions we recorded stress the importance of investigating circadian activity in more integrated ways.
en-copyright=
kn-copyright=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AbeMasato S
en-aut-sei=Abe
en-aut-mei=Masato S
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SharmaManmohan D
en-aut-sei=Sharma
en-aut-mei=Manmohan D
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HoskenDavid J
en-aut-sei=Hosken
en-aut-mei=David J
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshiiTaishi
en-aut-sei=Yoshii
en-aut-mei=Taishi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Center for Advanced Intelligence Project, RIKEN
kn-affil=

affil-num=3
en-affil=Centre for Ecology and Conservation, School of Biosciences, University of Exeter
kn-affil=

affil-num=4
en-affil=Centre for Ecology and Conservation, School of Biosciences, University of Exeter
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=circadian rhythm
kn-keyword=circadian rhythm
en-keyword=Gnatocerus cornutus
kn-keyword=Gnatocerus cornutus
en-keyword=isofemale line
kn-keyword=isofemale line
en-keyword=power of circadian rhythm
kn-keyword=power of circadian rhythm
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=3
article-no=
start-page=rjaa061
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200328
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Surgical resection for advanced bisphosphonate-related osteonecrosis of the jaw associated with fibrous dysplasia: a case report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an adverse drug reaction represented by destruction and/or death of bone. Fibrous dysplasia (FD) is a rare bony disorder characterised by abnormal fibro-osseous tissue that has lowered resistance to infection. Effective treatments for BRONJ that follows FD are unclear. Here, we report that advanced BRONJ associated with FD was successfully treated by surgical resection. A 69-year-old woman, whose left maxillary bone showed a ground glass appearance on computed tomography (CT) images, was taking alendronate. At 1 year after teeth within the abnormal bone were extracted, exposed bone was observed in the extraction sites and CT images revealed separated sequestrums. Under the clinical diagnosis of Stage 2 BRONJ with FD, we performed not only sequestrectomy but also a partial resection of the FD. Thereafter, the healing was uneventful without recurrence. In conclusion, our case suggests that surgical resection is useful for advanced BRONJ associated with FD.
en-copyright=
kn-copyright=

en-aut-name=MuraseYurika
en-aut-sei=Murase
en-aut-mei=Yurika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KishimotoKoji
en-aut-sei=Kishimoto
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshidaShoko
en-aut-sei=Yoshida
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KunisadaYuki
en-aut-sei=Kunisada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KadoyaKoichi
en-aut-sei=Kadoya
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=3
article-no=
start-page=225
end-page=229
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200128
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Adjuvant and neoadjuvant therapy for breast cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Systemic therapies for operable breast cancer patients have improved outcomes and have thus become standard treatments. Recently, new molecular target drugs and regimens are being developed based on the predicted sensitivity for specific breast cancer histological types. Systemic therapy is selected according to recurrence risk, with the treatment for low-risk patients being de-escalated, while high-risk patients receive aggressive systemic treatment with an adequate dose and duration. Neoadjuvant systemic therapy has a different aim. The efficacy of systemic therapies, based on the sensitivities to drugs, is supported by improvements in the rate of breast-conserving therapy. The response to neoadjuvant systemic therapy is the most important factor for predicting outcomes and selecting the optimal adjuvant therapy. Novel biological markers unique to individual patients allow appropriate targeted therapy, which can achieve optimal efficacy.
en-copyright=
kn-copyright=

en-aut-name=ShienTadahiko
en-aut-sei=Shien
en-aut-mei=Tadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IwataHiroji
en-aut-sei=Iwata
en-aut-mei=Hiroji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Okayama University Hospital
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=adjuvant
kn-keyword=adjuvant
en-keyword=neoadjuvant
kn-keyword=neoadjuvant
END

start-ver=1.4
cd-journal=joma
no-vol=220
cd-vols=
no-issue=1
article-no=
start-page=190
end-page=200
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Deformation of rhyolite lava crust associated with intermittent inner flow of lava: palaeomagnetic evidence
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A palaeomagnetic study has been conducted to examine the deformation of thick crusts of rhyolite lava while its inner portions continue to flow. The Sanukayama rhyolite lava, which erupted in the Pleistocene in Kozushima Island, Japan, was chosen as the investigation site because of its well-exposed vertical lithofacies variations classified into three distinct zones (pumiceous, obsidian and crystalline). The targets of this study are the pumiceous and obsidian zones, which constitute the crust of the lava. Thermal demagnetization reveals three remanent magnetization components from the pumiceous and obsidian samples but only a single magnetization component from the inner crystalline rhyolite samples. Alternating field demagnetization is ineffective in isolating the magnetization components in the pumiceous and obsidian samples. The multiple components of remanent magnetization of the crust are interpreted to have been acquired during cooling as thermoremanent magnetizations. We suspect intermittent lava transport of the inner portions, the primary mode of rhyolite lava advancement, to be responsible for the presence of multiple components in pumice and obsidian of the lava crust. When the inner portions of the lava retain mobility to flow out of the crust, the solidified crust of the lava surface below the magnetite Curie temperature remains susceptible to deformation. Analysis of palaeomagnetic directions from the crust allows the deformation of the crust to be described in terms of rotation. Although the mode of rhyolite lava advancement is not well understood, because of its infrequent occurrence, our observations offer an important insight on how the mobile part of the lava is associated with the deformation of the crust during continued lava advance.
en-copyright=
kn-copyright=

en-aut-name=UnoKoji
en-aut-sei=Uno
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurukawaKuniyuki
en-aut-sei=Furukawa
en-aut-mei=Kuniyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakaiKotaro
en-aut-sei=Nakai
en-aut-mei=Kotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KamioTakuma
en-aut-sei=Kamio
en-aut-mei=Takuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KanamaruTatsuo
en-aut-sei=Kanamaru
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Business Administration, Aichi University
kn-affil=

affil-num=3
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Earth and Environmental Sciences, Nihon University
kn-affil=
en-keyword=Asia
kn-keyword=Asia
en-keyword=Palaeomagnetism
kn-keyword=Palaeomagnetism
en-keyword=Rock and mineral magnetism
kn-keyword=Rock and mineral magnetism
en-keyword=Volcanic hazards and risks
kn-keyword=Volcanic hazards and risks
END

start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=3
article-no=
start-page=470
end-page=480
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191113
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Regulation of the Poly(A) Status of Mitochondrial mRNA by Poly(A)-Specific Ribonuclease Is Conserved among Land Plants
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Regulation of the stability and the quality of mitochondrial RNA is essential for the maintenance of mitochondrial and cellular functions in eukaryotes. We have previously reported that the eukaryotic poly(A)-specific ribonuclease (PARN) and the prokaryotic poly(A) polymerase encoded by AHG2 and AGS1, respectively, coordinately regulate the poly(A) status and the stability of mitochondrial mRNA in Arabidopsis. Mitochondrial function of PARN has not been reported in any other eukaryotes. To know how much this PARN-based mitochondrial mRNA regulation is conserved among plants, we studied the AHG2 and AGS1 counterparts of the liverwort, Marchantia polymorpha, a member of basal land plant lineage. We found that M. polymorpha has one ortholog each for AHG2 and AGS1, named MpAHG2 and MpAGS1, respectively. Their Citrine-fused proteins were detected in mitochondria of the liverwort. Molecular genetic analysis showed that MpAHG2 is essential and functionally interacts with MpAGS1 as observed in Arabidopsis. A recombinant MpAHG2 protein had a deadenylase activity in vitro. Overexpression of MpAGS1 and the reduced expression of MpAHG2 caused an accumulation of polyadenylated Mpcox1 mRNA. Furthermore, MpAHG2 suppressed Arabidopsis ahg2-1 mutant phenotype. These results suggest that the PARN-based mitochondrial mRNA regulatory system is conserved in land plants.
en-copyright=
kn-copyright=

en-aut-name=KanazawaMai
en-aut-sei=Kanazawa
en-aut-mei=Mai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IkedaYoko
en-aut-sei=Ikeda
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishihamaRyuichi
en-aut-sei=Nishihama
en-aut-mei=Ryuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamaokaShohei
en-aut-sei=Yamaoka
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=LeeNam-Hee
en-aut-sei=Lee
en-aut-mei=Nam-Hee
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamatoKatsuyuki T
en-aut-sei=Yamato
en-aut-mei=Katsuyuki T
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KohchiTakayuk
en-aut-sei=Kohchi
en-aut-mei=Takayuk
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HirayamaTakashi
en-aut-sei=Hirayama
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Division of Science for Bioresources, Graduate School of Environment and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Division of Science for Bioresources, Graduate School of Environment and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Biostudies, Kyoto University
kn-affil=

affil-num=4
en-affil=Graduate School of Biostudies, Kyoto University
kn-affil=

affil-num=5
en-affil=Department of Life Sciences, Faculty of Science and Engineering, Sorbonne University
kn-affil=

affil-num=6
en-affil=Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kindai University
kn-affil=

affil-num=7
en-affil=Graduate School of Biostudies, Kyoto University
kn-affil=

affil-num=8
en-affil=Division of Science for Bioresources, Graduate School of Environment and Life Science, Okayama University
kn-affil=
en-keyword=Arabidopsis
kn-keyword=Arabidopsis
en-keyword=Marchantia polymorpha
kn-keyword=Marchantia polymorpha
en-keyword=Mitochondria
kn-keyword=Mitochondria
en-keyword= Poly(A) polymerase
kn-keyword= Poly(A) polymerase
en-keyword=Poly(A) regulation
kn-keyword=Poly(A) regulation
en-keyword= Poly(A)-specific ribonuclease
kn-keyword= Poly(A)-specific ribonuclease
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=5
article-no=
start-page=399
end-page=409
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of molecular markers associated with resistance to Meloidogyne incognita by performing quantitative trait locus analysis and genome-wide association study in sweetpotato
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The southern root-knot nematode, Meloidogyne incognita, is a pest that decreases yield and the quality of sweetpotato [Ipomoea batatas (L.) Lam.]. There is a demand to produce resistant cultivars and develop DNA markers to select this trait. However, sweetpotato is hexaploid, highly heterozygous, and has an enormous genome (similar to 3 Gb), which makes genetic linkage analysis difficult. In this study, a high-density linkage map was constructed based on retrotransposon insertion polymorphism, simple sequence repeat, and single nucleotide polymorphism markers. The markers were developed using F-1 progeny between J-Red, which exhibits resistance to multiple races of M. incognita, and Choshu, which is susceptible to multiple races of such pest. Quantitative trait locus (QTL) analysis and a genome-wide association study detected highly effective QTLs for resistance against three races, namely, SP1, SP4, and SP6-1, in the Ib01-6 J-Red linkage group. A polymerase chain reaction marker that can identify genotypes based on single nucleotide polymorphisms located in this QTL region can discriminate resistance from susceptibility in the F-1 progeny at a rate of 70%. Thus, this marker could be helpful in selecting sweetpotato cultivars that are resistant to multiple races of M. incognita.
en-copyright=
kn-copyright=

en-aut-name=SasaiRumi
en-aut-sei=Sasai
en-aut-mei=Rumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TabuchiHiroaki
en-aut-sei=Tabuchi
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShirasawaKenta
en-aut-sei=Shirasawa
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KishimotoKazuki
en-aut-sei=Kishimoto
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SatoShusei
en-aut-sei=Sato
en-aut-mei=Shusei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkadaYoshihiro
en-aut-sei=Okada
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KuramotoAkihide
en-aut-sei=Kuramoto
en-aut-mei=Akihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KobayashiAkira
en-aut-sei=Kobayashi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IsobeSachiko
en-aut-sei=Isobe
en-aut-mei=Sachiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TaharaMakoto
en-aut-sei=Tahara
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MondenYuki
en-aut-sei=Monden
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Kyusyu Okinawa Agricultural Research Center, National Agriculture and Food Research Organization
kn-affil=

affil-num=3
en-affil=Kazusa DNA Research Institute
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Life Science, Tohoku University
kn-affil=

affil-num=6
en-affil=Kyusyu Okinawa Agricultural Research Center, National Agriculture and Food Research Organization
kn-affil=

affil-num=7
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=8
en-affil=Kyusyu Okinawa Agricultural Research Center, National Agriculture and Food Research Organization
kn-affil=

affil-num=9
en-affil=Kazusa DNA Research Institute
kn-affil=

affil-num=10
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=11
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=sweetpotato
kn-keyword=sweetpotato
en-keyword=GWAS
kn-keyword=GWAS
en-keyword=QTL mapping
kn-keyword=QTL mapping
en-keyword=polyploids
kn-keyword=polyploids
en-keyword=marker-assisted breeding
kn-keyword=marker-assisted breeding
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=2
article-no=
start-page=023D01
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190222
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Gamma-ray spectrum from thermal neutron capture on gadolinium-157
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We have measured the -ray energy spectrum from the thermal neutron capture, Gd, on an enriched Gd target (GdO) in the energy range from 0.11 MeV up to about 8 MeV. The target was placed inside the germanium spectrometer of the ANNRI detector at J-PARC and exposed to a neutron beam from the Japan Spallation Neutron Source (JSNS). Radioactive sources (Co, Cs, and Eu) and the Cl(,) reaction were used to determine the spectrometers detection efficiency for rays at energies from 0.3 to 8.5 MeV. Using a Geant4-based Monte Carlo simulation of the detector and based on our data, we have developed a model to describe the -ray spectrum from the thermal Gd(,) reaction. While we include the strength information of 15 prominent peaks above 5 MeV and associated peaks below 1.6 MeV from our data directly into the model, we rely on the theoretical inputs of nuclear level density and the photon strength function of Gd to describe the continuum -ray spectrum from the Gd(,) reaction. Our model combines these two components. The results of the comparison between the observed -ray spectra from the reaction and the model are reported in detail.
en-copyright=
kn-copyright=

en-aut-name=HagiwaraKaito
en-aut-sei=Hagiwara
en-aut-mei=Kaito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YanoTakatomi
en-aut-sei=Yano
en-aut-mei=Takatomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanakaTomoyuki
en-aut-sei=Tanaka
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ReenMandeep Singh
en-aut-sei=Reen
en-aut-mei=Mandeep Singh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=DasPretam Kumar
en-aut-sei=Das
en-aut-mei=Pretam Kumar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=LorenzSebastian
en-aut-sei=Lorenz
en-aut-mei=Sebastian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OuIwa
en-aut-sei=Ou
en-aut-mei=Iwa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SudoTakashi
en-aut-sei=Sudo
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamadaYoshiyuki
en-aut-sei=Yamada
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MoriTakaaki
en-aut-sei=Mori
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KayanoTsubasa
en-aut-sei=Kayano
en-aut-mei=Tsubasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=DhirRohit
en-aut-sei=Dhir
en-aut-mei=Rohit
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KoshioYusuke
en-aut-sei=Koshio
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SakudaMakoto
en-aut-sei=Sakuda
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KimuraAtsushi
en-aut-sei=Kimura
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=NakamuraShoji
en-aut-sei=Nakamura
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=IwamotoNobuyuki
en-aut-sei=Iwamoto
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=HaradaHideo
en-aut-sei=Harada
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=WurmMichael
en-aut-sei=Wurm
en-aut-mei=Michael
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=FocillonWilliam
en-aut-sei=Focillon
en-aut-mei=William
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=GoninMichel
en-aut-sei=Gonin
en-aut-mei=Michel
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=AliAjmi
en-aut-sei=Ali
en-aut-mei=Ajmi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=CollazuolGianmaria
en-aut-sei=Collazuol
en-aut-mei=Gianmaria
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

affil-num=1
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=2
en-affil=Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=3
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=15
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=16
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=17
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=18
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=19
en-affil=Institut für Physik, Johannes Gutenberg-Universität Mainz
kn-affil=

affil-num=20
en-affil=Département de Physique, École Polytechnique
kn-affil=

affil-num=21
en-affil=Département de Physique, École Polytechnique
kn-affil=

affil-num=22
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=23
en-affil=Universitá di Padova and INFN, Dipartimento di Fisica
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=6
article-no=
start-page=063H03
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190629
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of a method for measuring rare earth elements in the environment for future experiments with gadolinium-loaded detectors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Demand to use gadolinium (Gd) in detectors is increasing in the field of elementary particle physics, especially in neutrino measurements and dark matter searches. Large amounts of Gd are used in these experiments. To assess the impact of Gd on the environment it is becoming important to measure the baseline concentrations of Gd. Such measurement, however, is not easy due to interference by other elements. In this paper a method for measuring the concentrations of rare earth elements, including Gd, is proposed. In the method, inductively coupled plasma-mass spectrometry is utilized after collecting the dissolved elements in chelating resin. Results of the ability to detect anomalous concentrations of rare earth elements in river water samples in the Kamioka and Toyama areas are also reported.
en-copyright=
kn-copyright=

en-aut-name=ItoS.
en-aut-sei=Ito
en-aut-mei=S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkadaT.
en-aut-sei=Okada
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakakuY.
en-aut-sei=Takaku
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HaradaM.
en-aut-sei=Harada
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IkedaM.
en-aut-sei=Ikeda
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KishimotoY.
en-aut-sei=Kishimoto
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KoshioY.
en-aut-sei=Koshio
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakahataM.
en-aut-sei=Nakahata
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakajimaY.
en-aut-sei=Nakajima
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SekiyaH.
en-aut-sei=Sekiya
en-aut-mei=H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Okayama University, Faculty of Science
kn-affil=

affil-num=2
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=3
en-affil=Institute for Environmental Sciences, Department of Radioecology
kn-affil=

affil-num=4
en-affil=Okayama University, Faculty of Science
kn-affil=

affil-num=5
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=6
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=7
en-affil=Okayama University, Faculty of Science
kn-affil=

affil-num=8
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=9
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=10
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=8
article-no=
start-page=1681
end-page=1715
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Transition from Plume-driven to Plate-driven Magmatism in the Evolution of the Main Ethiopian Rift
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= New K-Ar ages, major and trace element concentrations, and Sr-Nd-Pb isotope data are presented for Oligocene to recent mafic volcanic rocks from the Ethiopian Plateau, the Main Ethiopian Rift (MER), and the Afar depression. Chronological and geochemical data from this study are combined with previously published datasets to reveal secular variations in magmatism throughout the entire Ethiopian volcanic region. The mafic lavas in these regions show variability in terms of silica-saturation (i.e. alkaline and sub-alkaline series) and extent of differentiation (mafic through intermediate to felsic). The P-T conditions of melting, estimated using the least differentiated basalts, reveal a secular decrease in the mantle potential temperature, from when the flood basalt magmas erupted (up to 1600 degrees C) to the time of the rift-related magmatism (<1500 degrees C). Variations in the Sr-Nd-Pb isotopic compositions of the mafic lavas can account for the involvement of multiple end-member components. The relative contributions of these end-member components vary in space and time owing to changes in the thermal condition of the asthenosphere and the thickness of the lithosphere. The evolution of the Ethiopian rift is caused by a transition from plume-driven to plate-driven mantle upwelling, although the present-day mantle beneath the MER and the Afar depression is still warmer than normal asthenosphere.
en-copyright=
kn-copyright=

en-aut-name=FeyissaDejene Hailemariam
en-aut-sei=Feyissa
en-aut-mei=Dejene Hailemariam
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KitagawaHiroshi
en-aut-sei=Kitagawa
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BizunehTesfaye Demissie
en-aut-sei=Bizuneh
en-aut-mei=Tesfaye Demissie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanakaRyoji
en-aut-sei=Tanaka
en-aut-mei=Ryoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KabetoKurkura
en-aut-sei=Kabeto
en-aut-mei=Kurkura
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakamuraEizo
en-aut-sei=Nakamura
en-aut-mei=Eizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=3
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=4
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=5
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=6
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=
en-keyword=Ethiopian Plateau
kn-keyword=Ethiopian Plateau
en-keyword=Ethiopian rift
kn-keyword=Ethiopian rift
en-keyword=Afar depression
kn-keyword=Afar depression
en-keyword=mantle source
kn-keyword=mantle source
en-keyword=mantle melting
kn-keyword=mantle melting
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=6
article-no=
start-page=1522
end-page=1529
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190705
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Artificial selection on walking distance suggests a mobility-sperm competitiveness trade-off
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Securing matings is a key determinant of fitness, and in many species, males are the sex that engages in mate searching. Searching for mates is often associated with increased mobility. This elevated investment in movement is predicted to trade-off with sperm competitiveness, but few studies have directly tested whether this trade-off occurs. Here, we assessed whether artificial selection on mobility affected sperm competitiveness and mating behavior, and if increased mobility was due to increased leg length in red flour beetles (Tribolium castaneum). We found that, in general, males selected for decreased mobility copulated for longer, stimulated females more during mating, and tended to be better sperm competitors. Surprisingly, they also had longer legs. However, how well males performed in sperm competition depended on females. Males with reduced mobility always copulated for longer than males with high mobility, but this only translated into greater fertilization success in females from control populations and not the selection populations (i.e. treatment females). These results are consistent with a mate-searching/mating-duration trade-off and broadly support a trade-off between mobility and sperm competitiveness.
en-copyright=
kn-copyright=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ArcherC Ruth
en-aut-sei=Archer
en-aut-mei=C Ruth
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Hosken David J
en-aut-sei=Hosken
en-aut-mei= David J
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Centre for Ecology & Conservation, University of Exeter
kn-affil=

affil-num=3
en-affil=Centre for Ecology & Conservation, University of Exeter
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=leg length
kn-keyword=leg length
en-keyword=mate searching
kn-keyword=mate searching
en-keyword=morphology
kn-keyword=morphology
en-keyword=sperm competition,
kn-keyword=sperm competition,
en-keyword=trade-off
kn-keyword=trade-off
en-keyword=Tribolium castaneum
kn-keyword=Tribolium castaneum
en-keyword=walking
kn-keyword=walking
END

start-ver=1.4
cd-journal=joma
no-vol=44
cd-vols=
no-issue=12
article-no=
start-page=5658
end-page=5672
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160407
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Toll-like receptor 5 (TLR5) expression in the intestinal epithelial cells (IECs) is critical to maintain health, as underscored by multiple intestinal and extra-intestinal diseases in mice genetically engineered for IEC-specific TLR5 knockout. A gradient of expression exists in the colonic epithelial cells from the cecum to the distal colon. Intriguingly, an identical gradient for the dietary metabolite, butyrate also exists in the luminal contents. However, both being critical for intestinal homeostasis and immune response, no studies examined the role of butyrate in the regulation of TLR5 expression. We showed that butyrate transcriptionally upregulates TLR5 in the IECs and augments flagellin-induced immune responses. Both basal and butyrate-induced transcription is regulated by differential binding of Sp-family transcription factors to the GC-box sequences over the TLR5 promoter. Butyrate activates two different protein kinase C isoforms to dephosphorylate/acetylate Sp1 by serine/threonine phosphatases and phosphorylate Sp3 by ERK-MAPK, respectively. This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes.
en-copyright=
kn-copyright=

en-aut-name=Bhupesh Kumar Thakur
en-aut-sei=Bhupesh Kumar Thakur
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DasguptaNirmalya
en-aut-sei=Dasgupta
en-aut-mei=Nirmalya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TaAtri
en-aut-sei=Ta
en-aut-mei=Atri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=DasSantasabuj
en-aut-sei=Das
en-aut-mei=Santasabuj
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Division of Clinical Medicine, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=2
en-affil=Division of Clinical Medicine, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=3
en-affil=Division of Clinical Medicine, National Institute of Cholera and Enteric Diseases
kn-affil=

affil-num=4
en-affil=Division of Clinical Medicine, National Institute of Cholera and Enteric Diseases
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=14
article-no=
start-page=9005
end-page=9020
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140717
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Nuclear dynamics of topoisomerase II beta reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=DNA topoisomerase II (topo II) changes DNA topology by cleavage/re-ligation cycle(s) and thus contributes to various nuclear DNA transactions. It is largely unknown how the enzyme is controlled in a nuclear context. Several studies have suggested that its C-terminal domain (CTD), which is dispensable for basal relaxation activity, has some regulatory influence. In this work, we examined the impact of nuclear localization on regulation of activity in nuclei. Specifically, human cells were transfected with wild-type and mutant topo II beta tagged with EGFP. Activity attenuation experiments and nuclear localization data reveal that the endogenous activity of topo II beta is correlated with its subnuclear distribution. The enzyme shuttles between an active form in the nucleoplasm and a quiescent form in the nucleolus in a dynamic equilibrium. Mechanistically, the process involves a tethering event with RNA. Isolated RNA inhibits the catalytic activity of topo II beta in vitro through the interaction with a specific 50-residue region of the CTD (termed the CRD). Taken together, these results suggest that both the subnuclear distribution and activity regulation of topo II beta are mediated by the interplay between cellular RNA and the CRD.
en-copyright=
kn-copyright=

en-aut-name=OnodaAkihisa
en-aut-sei=Onoda
en-aut-mei=Akihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HosoyaOsamu
en-aut-sei=Hosoya
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SanoKuniaki
en-aut-sei=Sano
en-aut-mei=Kuniaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KiyamaKazuko
en-aut-sei=Kiyama
en-aut-mei=Kazuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KimuraHiroshi
en-aut-sei=Kimura
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KawanoShinji
en-aut-sei=Kawano
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=FurutaRyohei
en-aut-sei=Furuta
en-aut-mei=Ryohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MiyajiMary
en-aut-sei=Miyaji
en-aut-mei=Mary
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TsutsuiKen
en-aut-sei=Tsutsui
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TsutsuiKimiko M.
en-aut-sei=Tsutsui
en-aut-mei=Kimiko M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurogen

affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurogen

affil-num=3
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurogen

affil-num=4
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurogen

affil-num=5
en-affil=
kn-affil=Osaka Univ, Grad Sch Frontier Biosci, Lab Biol Sci

affil-num=6
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurogen

affil-num=7
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurogen

affil-num=8
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurogen

affil-num=9
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurogen

affil-num=10
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurogen
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=19
article-no=
start-page=11903
end-page=11911
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140927
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=HSP90, found in all kingdoms of life, is a major chaperone protein regulating many client proteins. We demonstrated that HSP90α, one of two paralogs duplicated in vertebrates, plays an important role in the biogenesis of fetal PIWI-interacting RNAs (piRNA), which act against the transposon activities, in mouse male germ cells. The knockout mutation of Hsp90α resulted in a large reduction in the expression of primary and secondary piRNAs and mislocalization of MIWI2, a PIWI homolog. Whereas the mutation in Fkbp6 encoding a co-chaperone reduced piRNAs of 28–32 nucleotides in length, the Hsp90α mutation reduced piRNAs of 24–32 nucleotides, suggesting the presence of both FKBP6-dependent and -independent actions of HSP90α. Although DNA methylation and mRNA levels of L1 retrotransposon were largely unchanged in the Hsp90α mutant testes, the L1-encoded protein was increased, suggesting the presence of post-transcriptional regulation. This study revealed the specialized function of the HSP90α isofom in the piRNA biogenesis and repression of retrotransposons during the development of male germ cells in mammals.
en-copyright=
kn-copyright=

en-aut-name=IchiyanagiTomoko
en-aut-sei=Ichiyanagi
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IchiyanagiKenji
en-aut-sei=Ichiyanagi
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OgawaAyako
en-aut-sei=Ogawa
en-aut-mei=Ayako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Kuramochi-MiyagawaSatomi
en-aut-sei=Kuramochi-Miyagawa
en-aut-mei=Satomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakanoToru
en-aut-sei=Nakano
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ChumaShinichiro
en-aut-sei=Chuma
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SasakiHiroyuki
en-aut-sei=Sasaki
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=UdonoHeiichiro
en-aut-sei=Udono
en-aut-mei=Heiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Immunology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University

affil-num=3
en-affil=
kn-affil=Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University

affil-num=4
en-affil=
kn-affil=Department of Pathology, Medical School and Graduate School of Frontier Biosciences, Osaka University

affil-num=5
en-affil=
kn-affil=Department of Pathology, Medical School and Graduate School of Frontier Biosciences, Osaka University

affil-num=6
en-affil=
kn-affil=Department of Development and Differentiation, Institute for Frontier Medical Sciences, Kyoto University

affil-num=7
en-affil=
kn-affil=Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University

affil-num=8
en-affil=
kn-affil=Department of Immunology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140616
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Efficient DNA Fingerprinting Based on the Targeted Sequencing of Active Retrotransposon Insertion Sites Using a Bench-Top High-Throughput Sequencing Platform
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In many crop species, DNA fingerprinting is required for the precise identification of cultivars to protect the rights of breeders. Many families of retrotransposons have multiple copies throughout the eukaryotic genome and their integrated copies are inherited genetically. Thus, their insertion polymorphisms among cultivars are useful for DNA fingerprinting. In this study, we conducted a DNA fingerprinting based on the insertion polymorphisms of active retrotransposon families (Rtsp-1 and LIb) in sweet potato. Using 38 cultivars, we identified 2024 insertion sites in the two families with an Illumina MiSeq sequencing platform. Of these insertion sites, 91.4% appeared to be polymorphic among the cultivars and 376 cultivar-specific insertion sites were identified, which were converted directly into cultivar-specific sequence-characterized amplified region (SCAR) markers. A phylogenetic tree was constructed using these insertion sites, which corresponded well with known pedigree information, thereby indicating their suitability for genetic diversity studies. Thus, the genome-wide comparative analysis of active retrotransposon insertion sites using the bench-top MiSeq sequencing platform is highly effective for DNA fingerprinting without any requirement for whole genome sequence information. This approach may facilitate the development of practical polymerase chain reaction-based cultivar diagnostic system and could also be applied to the determination of genetic relationships.
en-copyright=
kn-copyright=

en-aut-name=MondenYuki
en-aut-sei=Monden
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoAyaka
en-aut-sei=Yamamoto
en-aut-mei=Ayaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShindoAkiko
en-aut-sei=Shindo
en-aut-mei=Akiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TaharaMakoto
en-aut-sei=Tahara
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Environmental and Life Science, Okayama University

affil-num=2
en-affil=
kn-affil=Faculty of Agriculture, Okayama University

affil-num=3
en-affil=
kn-affil=Graduate School of Environmental and Life Science, Okayama University

affil-num=4
en-affil=
kn-affil=Graduate School of Environmental and Life Science, Okayama University
en-keyword=DNA fingerprinting
kn-keyword=DNA fingerprinting
en-keyword=high-throughput sequencing
kn-keyword=high-throughput sequencing
en-keyword=molecular marker
kn-keyword=molecular marker
en-keyword=retrotransposon
kn-keyword=retrotransposon
en-keyword=sweet potato
kn-keyword=sweet potato
END

start-ver=1.4
cd-journal=joma
no-vol=38
cd-vols=
no-issue=
article-no=
start-page=D26
end-page=D32
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=201001
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=NBRP databases: databases of biological resources in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The National BioResource Project (NBRP) is a Japanese project that aims to establish a system for collecting, preserving and providing bioresources for use as experimental materials for life science research. It is promoted by 27 core resource facilities, each concerned with a particular group of organisms, and by one information center. The NBRP database is a product of this project. Thirty databases and an integrated database-retrieval system (BioResource World: BRW) have been created and made available through the NBRP home page (http://www.nbrp.jp). The 30 independent databases have individual features which directly reflect the data maintained by each resource facility. The BRW is designed for users who need to search across several resources without moving from one database to another. BRW provides access to a collection of 4.5-million records on bioresources including wild species, inbred lines, mutants, genetically engineered lines, DNA clones and so on. BRW supports summary browsing, keyword searching, and searching by DNA sequences or gene ontology. The results of searches provide links to online requests for distribution of research materials. A circulation system allows users to submit details of papers published on research conducted using NBRP resources.
en-copyright=
kn-copyright=

en-aut-name=YamazakiYukiko
en-aut-sei=Yamazaki
en-aut-mei=Yukiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AkashiRyo
en-aut-sei=Akashi
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BannoYutaka
en-aut-sei=Banno
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=EndoTakashi
en-aut-sei=Endo
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=EzuraHiroshi
en-aut-sei=Ezura
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Fukami-KobayashiKaoru
en-aut-sei=Fukami-Kobayashi
en-aut-mei=Kaoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=InabaKazuo
en-aut-sei=Inaba
en-aut-mei=Kazuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IsaTadashi
en-aut-sei=Isa
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KameiKatsuhiko
en-aut-sei=Kamei
en-aut-mei=Katsuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KasaiFumie
en-aut-sei=Kasai
en-aut-mei=Fumie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KobayashiMasatomo
en-aut-sei=Kobayashi
en-aut-mei=Masatomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KurataNori
en-aut-sei=Kurata
en-aut-mei=Nori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KusabaMakoto
en-aut-sei=Kusaba
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=MatuzawaTetsuro
en-aut-sei=Matuzawa
en-aut-mei=Tetsuro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=MitaniShohei
en-aut-sei=Mitani
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=NakamuraTaro
en-aut-sei=Nakamura
en-aut-mei=Taro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=NakamuraYukio
en-aut-sei=Nakamura
en-aut-mei=Yukio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=NakatsujiNorio
en-aut-sei=Nakatsuji
en-aut-mei=Norio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=NaruseKiyoshi
en-aut-sei=Naruse
en-aut-mei=Kiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=NikiHironori
en-aut-sei=Niki
en-aut-mei=Hironori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=NitasakaEiji
en-aut-sei=Nitasaka
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=ObataYuichi
en-aut-sei=Obata
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=OkamotoHitoshi
en-aut-sei=Okamoto
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

en-aut-name=OkumaMoriya
en-aut-sei=Okuma
en-aut-mei=Moriya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=24
ORCID=

en-aut-name=SatoKazuhiro
en-aut-sei=Sato
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=25
ORCID=

en-aut-name=SerikawaTadao
en-aut-sei=Serikawa
en-aut-mei=Tadao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=26
ORCID=

en-aut-name=ShiroishiToshihiko
en-aut-sei=Shiroishi
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=27
ORCID=

en-aut-name=SugawaraHideaki
en-aut-sei=Sugawara
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=28
ORCID=

en-aut-name=UrushibaraHideko
en-aut-sei=Urushibara
en-aut-mei=Hideko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=29
ORCID=

en-aut-name=YamamotoMasatoshi
en-aut-sei=Yamamoto
en-aut-mei=Masatoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=30
ORCID=

en-aut-name=YaoitaYoshio
en-aut-sei=Yaoita
en-aut-mei=Yoshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=31
ORCID=

en-aut-name=YoshikiAtsushi
en-aut-sei=Yoshiki
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=32
ORCID=

en-aut-name=KoharaYuji
en-aut-sei=Kohara
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=33
ORCID=

affil-num=1
en-affil=
kn-affil=Natl Inst Genet

affil-num=2
en-affil=
kn-affil=Miyazaki Univ

affil-num=3
en-affil=
kn-affil=Kyushu Univ

affil-num=4
en-affil=
kn-affil=Kyoto Univ

affil-num=5
en-affil=
kn-affil=Univ Tsukuba

affil-num=6
en-affil=
kn-affil=RIKEN, BioResource Ctr

affil-num=7
en-affil=
kn-affil=Univ Tsukuba

affil-num=8
en-affil=
kn-affil=

affil-num=9
en-affil=
kn-affil=Chiba Univ

affil-num=10
en-affil=
kn-affil=Natl Inst Environm Studies

affil-num=11
en-affil=
kn-affil=RIKEN, BioResource Ctr

affil-num=12
en-affil=
kn-affil=Natl Inst Genet

affil-num=13
en-affil=
kn-affil=Hiroshima Univ

affil-num=14
en-affil=
kn-affil=Kyoto Univ

affil-num=15
en-affil=
kn-affil=Tokyo Womens Med Univ

affil-num=16
en-affil=
kn-affil=RIKEN, BioResource Ctr

affil-num=17
en-affil=
kn-affil=

affil-num=18
en-affil=
kn-affil=Kyoto Univ

affil-num=19
en-affil=
kn-affil=

affil-num=20
en-affil=
kn-affil=Natl Inst Genet

affil-num=21
en-affil=
kn-affil=Kyushu Univ

affil-num=22
en-affil=
kn-affil=RIKEN, BioResource Ctr

affil-num=23
en-affil=
kn-affil=RIKEN, Brain Sci Inst

affil-num=24
en-affil=
kn-affil=RIKEN, BioResource Ctr

affil-num=25
en-affil=
kn-affil=Okayama Univ

affil-num=26
en-affil=
kn-affil=Kyoto Univ

affil-num=27
en-affil=
kn-affil=Natl Inst Genet

affil-num=28
en-affil=
kn-affil=Natl Inst Genet

affil-num=29
en-affil=
kn-affil=Univ Tsukuba

affil-num=30
en-affil=
kn-affil=Kyoto Inst Technol

affil-num=31
en-affil=
kn-affil=Hiroshima Univ

affil-num=32
en-affil=
kn-affil=RIKEN, BioResource Ctr

affil-num=33
en-affil=
kn-affil=Natl Inst Genet
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=6
article-no=
start-page=487
end-page=497
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Discovery of High-Confidence Single Nucleotide Polymorphisms from Large-Scale De Novo Analysis of Leaf Transcripts of Aegilops tauschii, A Wild Wheat Progenitor
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Construction of high-resolution genetic maps is important for genetic and genomic research, as well as for molecular breeding. Single nucleotide polymorphisms (SNPs) are the,predominant class of genetic variation and can be used as molecular markers. Aegilops tauschii, the D-genome donor of common wheat, is considered a valuable genetic resource for wheat improvement. Our previous study implied that Ae. tauschii accessions can be genealogically divided into two major lineages. In this study, the transcriptome of two Ae. tauschii accessions from each lineage, lineage 1 (L1) and 2 (L2), was sequenced, yielding 9435 SNPs and 739 insertion/deletion polymorphisms (indels) after de novo assembly of the reads. Based on 36 contig sequences, 31 SNPs and six indels were validated on 20 diverse Ae. tauschii accessions. Because almost all of the SNP markers were polymorphic between L1 and L2, and the D-genome donor of common wheat is presumed to belong to L2, these markers are available for D-genome typing in crosses between common wheat varieties and L1-derived synthetic wheat. Due to the conserved synteny between wheat and barley chromosomes, the high-density expressed sequence tag barley map and the hypothetical gene order in barley can be applied to develop markers on target chromosomal regions in wheat.
en-copyright=
kn-copyright=

en-aut-name=IehisaJulio Cesar Masaru
en-aut-sei=Iehisa
en-aut-mei=Julio Cesar Masaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShimizuAkifumi
en-aut-sei=Shimizu
en-aut-mei=Akifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SatoKazuhiro
en-aut-sei=Sato
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NasudaShuhei
en-aut-sei=Nasuda
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakumiShigeo
en-aut-sei=Takumi
en-aut-mei=Shigeo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Kobe Univ, Grad Sch Agr Sci, Lab Plant Genet

affil-num=2
en-affil=
kn-affil=Univ Shiga Prefecture, Dept Biol Resources Management, Sch Environm Sci

affil-num=3
en-affil=
kn-affil=Okayama Univ, Inst Plant Sci & Resources

affil-num=4
en-affil=
kn-affil=Kyoto Univ, Grad Sch Agr, Lab Plant Genet

affil-num=5
en-affil=
kn-affil=Kobe Univ, Grad Sch Agr Sci, Lab Plant Genet
en-keyword=Aegilops tauschii
kn-keyword=Aegilops tauschii
en-keyword=expression sequence tag
kn-keyword=expression sequence tag
en-keyword=next generation sequencing
kn-keyword=next generation sequencing
en-keyword=single nucleotide polymorphism
kn-keyword=single nucleotide polymorphism
en-keyword=wheat
kn-keyword=wheat
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=2
article-no=
start-page=81
end-page=89
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of 5006 Full-Length CDNAs in Barley: A Tool for Accessing Cereal Genomics Resources
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A collection of 5006 full-length (FL) cDNA sequences was developed in barley. Fifteen mRNA samples from various organs and treatments were pooled to develop a cDNA library using the CAP trapper method. More than 60% of the clones were confirmed to have complete coding sequences, based on comparison with rice amino acid and UniProt sequences. Blastn homologies (E < 1E-5) to rice genes and Arabidopsis genes were 89 and 47%, respectively. Of the 5028 possible amino acid sequences derived from the 5006 FLcDNAs, 4032 (80.2%) were classified into 1678 GreenPhyl multigenic families. There were 555 cDNAs showing low homology to both rice and Arabidopsis. Gene ontology annotation by InterProScan indicated that many of these cDNAs (71%) have no known molecular functions and may be unique to barley. The cDNAs showed high homology to Barley 1 GeneChip oligo probes (81%) and the wheat gene index (84%). The high homology between FLcDNAs (27%) and mapped barley expressed sequence tag enabled assigning linkage map positions to 151-233 FLcDNAs on each of the seven barley chromosomes. These comprehensive barley FLcDNAs provide strong platform to connect preexisting genomic and genetic resources and accelerate gene identification and genome analysis in barley and related species.
en-copyright=
kn-copyright=

en-aut-name=SatoKazuhiro
en-aut-sei=Sato
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Shin-ITadasu
en-aut-sei=Shin-I
en-aut-mei=Tadasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SekiMotoaki
en-aut-sei=Seki
en-aut-mei=Motoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShinozakiKazuo
en-aut-sei=Shinozaki
en-aut-mei=Kazuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshidaHideya
en-aut-sei=Yoshida
en-aut-mei=Hideya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakedaKazuyoshi
en-aut-sei=Takeda
en-aut-mei=Kazuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamazakiYukiko
en-aut-sei=Yamazaki
en-aut-mei=Yukiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ConteMatthieu
en-aut-sei=Conte
en-aut-mei=Matthieu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KoharaYuji
en-aut-sei=Kohara
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Bioresources Res Inst

affil-num=2
en-affil=
kn-affil=Natl Inst Genet

affil-num=3
en-affil=
kn-affil=RIKEN, Plant Sci Ctr

affil-num=4
en-affil=
kn-affil=RIKEN, Plant Sci Ctr

affil-num=5
en-affil=
kn-affil=Okayama Univ, Bioresources Res Inst

affil-num=6
en-affil=
kn-affil=Okayama Univ, Bioresources Res Inst

affil-num=7
en-affil=
kn-affil=Natl Inst Genet

affil-num=8
en-affil=
kn-affil=Int Rice Res Inst, Crop Res Informat Lab

affil-num=9
en-affil=
kn-affil=Natl Inst Genet
en-keyword=full-length cDNA
kn-keyword=full-length cDNA
en-keyword=Hordeum vulgare
kn-keyword=Hordeum vulgare
en-keyword=mRNA
kn-keyword=mRNA
en-keyword=gene ontology
kn-keyword=gene ontology
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=4
article-no=
start-page=448
end-page=457
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genome-wide deficiency mapping of the regions responsible for temporal canalization of the developmental processes of Drosophila melanogaster
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Developmental processes of organisms are programed to proceed in a finely regulated manner and finish within a certain period of time depending on the ambient environmental conditions. Therefore, variation in the developmental period under controlled genetic and environmental conditions indicates innate instability of the developmental process. In this study, we aimed to determine whether a molecular machinery exists that regulates the canalization of the developmental period and, if so, to test whether the same mechanism also stabilizes a morphological trait. To search for regions that influence the instability of the developmental period, we conducted genome-wide deficiency mapping with 441 isogenic deficiency strains covering 65.5% of the Drosophila melanogaster genome. We found that 11 independent deficiencies significantly increased the instability of the developmental period and 5 of these also significantly increased the fluctuating asymmetry of wing shape although there was no significant correlation between the instabilities of developmental period and wing shape in general. These results suggest that canalization processes of the developmental period and morphological traits are at least partially independent. Our findings emphasize the potential importance of temporal variation in development as an indicator of developmental stability and canalization and provide a novel perspective for understanding the regulation of phenotypic variability.
en-copyright=
kn-copyright=

en-aut-name=TakahashiKazuo H.
en-aut-sei=Takahashi
en-aut-mei=Kazuo H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkadaYasukazu
en-aut-sei=Okada
en-aut-mei=Yasukazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TeramuraKouhei
en-aut-sei=Teramura
en-aut-mei=Kouhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Environmental Science, Okayama University

affil-num=3
en-affil=
kn-affil=Graduate School of Environmental Science, Okayama University
en-keyword=developmental period
kn-keyword=developmental period
en-keyword=developmental stability
kn-keyword=developmental stability
en-keyword=Drosophila melanogaster
kn-keyword=Drosophila melanogaster
en-keyword=wing shape
kn-keyword=wing shape
END

start-ver=1.4
cd-journal=joma
no-vol=146
cd-vols=
no-issue=1-3
article-no=
start-page=360
end-page=363
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201107
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl<sub>4</sub>) administration. Results showed that radon inhalation alleviates CCl<sub>4</sub>-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.
en-copyright=
kn-copyright=

en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshimotoMasaaki
en-aut-sei=Yoshimoto
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakagawaShinya
en-aut-sei=Nakagawa
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ToyotaTeruaki
en-aut-sei=Toyota
en-aut-mei=Teruaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamatoKeiko
en-aut-sei=Yamato
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KawabeAtsushi
en-aut-sei=Kawabe
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=4
en-affil=
kn-affil=Sakakibara Heart Institute of Okayama

affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=6
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=7
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=8
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center

affil-num=9
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=10
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=11
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=12
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
END