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ID 48709
フルテキストURL
著者
Yamaoka, Kiyonori Departments of Radiological Technology, Okayama University Medical School
Mitsunobu, Fumihiro Misasa Medical Center, Okayama University Medical School
Kojima, Shuji Faculty of Pharmaceutical Sciences, Science University of Tokyo
Shibakura, Misako Departments of Medical Technology, Okayama University Medical School
Kataoka, Takahiro Departments of Radiological Technology, Okayama University Medical School
Hanamoto, Katsumi Departments of Radiological Technology, Okayama University Medical School
Tanizaki, Yoshiro Misasa Medical Center, Okayama University Medical School
抄録
To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer-suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur.
キーワード
Radon hot spring
Misasa
Cancer-related mortality rate
p53 protein level
Superoxide dismutase activity
発行日
2005-04-01
出版物タイトル
Journal of Radiation Research
46巻
1号
出版者
Journal of Radiation Research Editorial Committee
開始ページ
21
終了ページ
24
ISSN
0449-3060
NCID
AA00705792
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/jrr/46/1/46_1_21/_article
言語
English
OAI-PMH Set
岡山大学
著作権者
Copyright © 2005 by Journal of Radiation Research Editorial Committee
論文のバージョン
publisher
査読
有り
DOI
PubMed ID
Web of Sience KeyUT