start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=6
article-no=
start-page=775
end-page=781
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20111122
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Study of the Response of Superoxide Dismutase in Mouse Organs to Radon Using a New Large-scale Facility for Exposing Small Animals to Radon
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We examined dose?dependent or dose rate?dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m3 for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day?Bq/m3, activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose?rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=ToyotaTeruaki
en-aut-sei=Toyota
en-aut-mei=Teruaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=TanakaHiroshi
en-aut-sei=Tanaka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=7
en-affil=
kn-affil=Misasa Medical Center, Okayama University Hospital
affil-num=8
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=Radon
kn-keyword=Radon
en-keyword=Superoxide dismutase
kn-keyword=Superoxide dismutase
en-keyword=Dose
kn-keyword=Dose
en-keyword=Dose rate
kn-keyword=Dose rate
en-keyword=Large-scale facility
kn-keyword=Large-scale facility
END
start-ver=1.4
cd-journal=joma
no-vol=45
cd-vols=
no-issue=1
article-no=
start-page=89
end-page=95
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040507
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibitory Effects of Prior Low-dose X-ray Irradiation on Carbon Tetrachloride-induced Hepatopathy in Acatalasemic Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.
en-copyright=
kn-copyright=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NomuraTakaharu
en-aut-sei=Nomura
en-aut-mei=Takaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=WangDa-Hong
en-aut-sei=Wang
en-aut-mei=Da-Hong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MoriShuji
en-aut-sei=Mori
en-aut-mei=Shuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KiraShohei
en-aut-sei=Kira
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=
kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
affil-num=2
en-affil=
kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
affil-num=3
en-affil=
kn-affil=Low Dose Radiation Research Center, Central Research Institute of Electric Power Industry
affil-num=4
en-affil=
kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
affil-num=5
en-affil=
kn-affil=Public Health, Okayama University Medical School
affil-num=6
en-affil=
kn-affil=Pharmacology, Okayama University Medical School
affil-num=7
en-affil=
kn-affil=Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School
affil-num=8
en-affil=
kn-affil=Public Health, Okayama University Medical School
en-keyword=Acatalasemic mouse
kn-keyword=Acatalasemic mouse
en-keyword=Catalase
kn-keyword=Catalase
en-keyword=CCl4
kn-keyword=CCl4
en-keyword=Hepatotoxicity
kn-keyword=Hepatotoxicity
en-keyword=Low-dose X-irradiation
kn-keyword=Low-dose X-irradiation
en-keyword=Antioxidant substances
kn-keyword=Antioxidant substances
END
start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=1
article-no=
start-page=21
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Elevation of p53 Protein Level and SOD Activity in the Resident Blood of the Misasa Radon Hot Spring District
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer-suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur.
en-copyright=
kn-copyright=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KojimaShuji
en-aut-sei=Kojima
en-aut-mei=Shuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=ShibakuraMisako
en-aut-sei=Shibakura
en-aut-mei=Misako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
affil-num=1
en-affil=
kn-affil=Departments of Radiological Technology, Okayama University Medical School
affil-num=2
en-affil=
kn-affil=Misasa Medical Center, Okayama University Medical School
affil-num=3
en-affil=
kn-affil=Faculty of Pharmaceutical Sciences, Science University of Tokyo
affil-num=4
en-affil=
kn-affil=Departments of Medical Technology, Okayama University Medical School
affil-num=5
en-affil=
kn-affil=Departments of Radiological Technology, Okayama University Medical School
affil-num=6
en-affil=
kn-affil=Departments of Radiological Technology, Okayama University Medical School
affil-num=7
en-affil=
kn-affil=Misasa Medical Center, Okayama University Medical School
en-keyword=Radon hot spring
kn-keyword=Radon hot spring
en-keyword=Misasa
kn-keyword=Misasa
en-keyword=Cancer-related mortality rate
kn-keyword=Cancer-related mortality rate
en-keyword=p53 protein level
kn-keyword=p53 protein level
en-keyword=Superoxide dismutase activity
kn-keyword=Superoxide dismutase activity
END
start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=6
article-no=
start-page=505
end-page=513
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20071121
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibitory Effects of Prior Low-dose X-irradiation on Ischemia-reperfusion Injury in Mouse Paw
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At 1 hr after reperfusion from ischemia for 1 hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or 1 hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MizuguchiYuko
en-aut-sei=Mizuguchi
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=YoshimotoMasaaki
en-aut-sei=Yoshimoto
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=Edema
kn-keyword=Edema
en-keyword=Ischemia-reperfusion injury
kn-keyword=Ischemia-reperfusion injury
en-keyword=Low-dose irradiation
kn-keyword=Low-dose irradiation
en-keyword=Reactive oxygen species
kn-keyword=Reactive oxygen species
en-keyword=Antioxidation function
kn-keyword=Antioxidation function
END