start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=2
article-no=
start-page=46
end-page=47
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190628
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Highlights: Focus on Immunodeficiency-Associated Lymphoproliferative Disorders
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SatoYasuharu
en-aut-sei=Sato
en-aut-mei=Yasuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=EBV-positive mucocutaneous ulcer
kn-keyword=EBV-positive mucocutaneous ulcer
en-keyword=Immunodeficiency-associated LPD
kn-keyword=Immunodeficiency-associated LPD
en-keyword=MTX
kn-keyword=MTX
en-keyword=immunosuppressive drugs
kn-keyword=immunosuppressive drugs
en-keyword=spontaneous regression
kn-keyword=spontaneous regression
END

start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=2
article-no=
start-page=64
end-page=6471
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190628
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Epstein-Barr virus (EBV)-positive mucocutaneous ulcers (EBVMCUs) were first described as a lymphoproliferative disorder in 2010. Clinically, EBVMCUs are shallow, sharply circumscribed, unifocal mucosal or cutaneous ulcers that occur in immunosuppressed patients, including those with advanced age-associated immunosenescence, iatrogenic immunosuppression, primary immune disorders, and HIV/AIDS-associated immune deficiencies. In general, patients exhibit indolent disease progression and spontaneous regression. Histologically, EBVMCUs are characterized by the proliferation of EBV-positive, variable-sized, atypical B-cells. According to conventional histopathologic criteria, EBVMCUs may diagnosed as lymphomas. However, EBVMCUs are recognized as pseudomalignant lesions because they spontaneously regress without anti-cancer treatment. Therefore, overtreatment must be carefully avoided and multilateral differentiation is important. In this article, we reviewed previously reported EBVMCUs focusing on their clinical and pathological aspects in comparison with other EBV-positive B-cell neoplasms.
en-copyright=
kn-copyright=

en-aut-name=IkedaTomoka
en-aut-sei=Ikeda
en-aut-mei=Tomoka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=GionYuka
en-aut-sei=Gion
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshinoTadashi
en-aut-sei=Yoshino
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SatoYasuharu
en-aut-sei=Sato
en-aut-mei=Yasuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Division of Pathophysiology, Okayama University Graduate School of Health Sciences
kn-affil=

affil-num=3
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=EBV-positive mucocutaneous ulcer
kn-keyword=EBV-positive mucocutaneous ulcer
en-keyword=clinical features
kn-keyword=clinical features
en-keyword=immunosuppression
kn-keyword=immunosuppression
en-keyword=pathological features
kn-keyword=pathological features
END

start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=4
article-no=
start-page=168
end-page=174
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191222
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Are there primary intraocular lymphomas that do not develop into central nervous system lymphomas?
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Primary intraocular lymphomas frequently develop into central nervous system lymphomas and vice versa. This study reviewed 22 consecutive patients with primary intraocular lymphoma diagnosed by immunostaining of vitrectomy cell blocks, and examined whether they developed central nervous system lymphoma. Seventeen patients developed central nervous system lymphoma: 3 patients developed intraocular and central nervous system lymphoma simultaneously, 9 patients developed central nervous system lymphoma 1 month to 5 years (median, 3 months) after intraocular lymphoma, and 5 patients developed central nervous system lymphoma preceding the diagnosis of intraocular lymphoma by 3 months to 9 years and 8 months (median, 1.5 years). In contrast, 5 patients did not develop central nervous system lymphoma: 2 patients did not develop local recurrence or central nervous system lymphoma in the follow-up period of 5 years and 11 years, respectively, after vitrectomy alone without additional local or systemic treatment. The remaining 3 patients with intraocular lymphoma had insufficient follow-up periods to determine the prognosis. The results of CD5 immunostaining of vitrectomy specimens were found in pathology reports of 8 patients: 3 patients with CD5-positive large cells and 4 patients with CD5-negative large cells developed central nervous system lymphoma. In summary, only a small number of patients did not develop central nervous system lymphoma based on long-term follow-up after vitrectomy alone. CD5 was not a marker of central nervous system involvement in this study population.
en-copyright=
kn-copyright=

en-aut-name=MatsuoToshihiko
en-aut-sei=Matsuo
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Ophthalmology, Okayama University Hospital and Okayama University Medical School
kn-affil=

affil-num=2
en-affil=Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Intraocular lymphoma
kn-keyword=Intraocular lymphoma
en-keyword= central nervous system lymphoma
kn-keyword= central nervous system lymphoma
en-keyword=CD5
kn-keyword=CD5
en-keyword=vitrectomy cell block
kn-keyword=vitrectomy cell block
en-keyword=diffuse large B-cell lymphoma
kn-keyword=diffuse large B-cell lymphoma
END