このエントリーをはてなブックマークに追加
ID 34248
フルテキストURL
著者
Kimura, Yoshinobu Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University
Sakamura, Sho Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University
Ushijima, Takayuki Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University
Hama, Yoichiro Department of Applied Biological Sciences, Faculty of Agriculture, Saga University
Kajiura, Hiroyuki The International Center for Biotechnology, Osaka University
Fujiyama, Kazuhito The International Center for Biotechnology, Osaka University
Okihara, Kiyoshi Yamada Apiculture Center, Inc.
Hashimoto, Ken Yamada Apiculture Center, Inc.
Sugimoto, Hiroyuki Yamada Apiculture Center, Inc.
Yamada, Hideo Yamada Apiculture Center, Inc.
抄録
In a previous study (Y. Kimura et al., Biosci. Biotechnol Biochem., 70, 2583-2587, 2006), we found that new complex type N-glycans harboring Thomsen-Friedenreich antigen (Ga1 beta 1-3GalNAc) unit occur on royal jelly glycoproteins, suggesting the involvement of a new beta 1-3galactosyltransferase in the synthesis of the unusual complex type N-glycans. So far, such beta 1-3galactosyltransferase activity, which can transfer galactosyl residues with the beta 1-3 linkage to beta 1-4 GalNAc residues in N-glycan, has not been found among any eucaryotic cells. But using GalNAc(2)GlcNAc(2)Man(3)-GlcNAc(2)-PA as acceptor N-glycan, we detected the beta 1-3 galactosyltransferase activity in membrane fraction prepared from honeybee cephalic portions. This result indicates that honeybee expresses a unique beta 1-3 galactosyltransferase involved in biosynthesis of the unusual N-glycan containing a tumor related antigen in the hypopharyngeal gland.
キーワード
royal jelly glycoprotein; N-glycan
Thomsen-Friedenreich antigen (Gal beta 1-3GalNAc)
beta 1-3 galactosyltransferase
Apis mellifera
備考
Published with permission from the copyright holder.
This is published in Bioscience Biotechnology and Biochemistry, 2007 Vol.71 Issue.4 pp.1111-1114
Publisher URL: http://dx.doi.org/10.1271/bbb.70081
Direct access to Thomson Web of Science record
(C)2008 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
発行日
2007-04
出版物タイトル
Bioscience, Biotechnology, and Biochemistry
71巻
4号
出版者
Japan Society for Bioscience, Biotechnology, and Agrochemistry
出版者(別表記)
日本農芸化学会
開始ページ
1111
終了ページ
1114
ISSN
0916-8451
NCID
AA10824164
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
Japan Society for Bioscience, Biotechnology and Agrochemistry
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT
Submission Path
biochemistry/18