start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=4 article-no= start-page=241 end-page=251 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080425 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Basic Study on Activation of Antioxidation Function in Some Organs of Mice by Radon Inhalation Using New Radon Exposure Device kn-title=ラドン吸入試作装置によるマウス諸臓器中の抗酸化機能の亢進に関する研究 en-subtitle= kn-subtitle= en-abstract=There are a lot of life style diseases that are related to reactive oxygen species in indications of the radon therapy, and, the further clarification of mechanism is expected. Therefore, in this study, we investigated the activation of antioxidation function in some organs of mice by radon inhalation using the new radon exposure device. It was enable that this device was the adjustments of radon concentration by changing the air flow rate to the specially processed radon source and so on. The mice were made to inhale the radon of 400Bq/m3 or 4000Bq/m3 with this device. Results show that in brain, lungs, liver, and kidney, both the activities of superoxide dismutase(SOD) and catalase increased, and lipid peroxide levels decreased. This suggests that radon inhalation enhanced the antioxidation function. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases. kn-abstract=ラドン療法の適応症には活性酸素に由来する生活習慣病が多く，その機構の更なる解明が期待されている。また，汎用性があり医学的効果が再現できるラドン吸入装置の構築は意義が大きい。このため，著者らは共同で開発したラドン吸入試作装置を用い，マウス諸臓器中の抗酸化機能の変化特性を検討した。ラドン吸入試作装置は，特殊加工したラドン線源を収納したユニットの数量，それへの送風量及び湿度などを調節することによりラドン濃度を自在に調整可能にするものである。この装置によりマウスに400Bq/m3あるいは4000Bq/m3のラドンを吸入させた。その結果，脳・肺・肝臓・腎臓において，抗酸化系酵素であるSODとカタラーゼの両活性が増加し，過酸化脂質量が減少した。この抗酸化機能の亢進により，本実験条件でのラドン吸入は活性酸素障害の抑制，すなわち，生活習慣病の予防や症状緩和に効果のある可能性が改めて示唆できた。 en-copyright= kn-copyright= en-aut-name=NakagawaShinya en-aut-sei=Nakagawa en-aut-mei=Shinya kn-aut-name=中川慎也 kn-aut-sei=中川 kn-aut-mei=慎也 aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name=片岡隆浩 kn-aut-sei=片岡 kn-aut-mei=隆浩 aut-affil-num=2 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name=迫田晃弘 kn-aut-sei=迫田 kn-aut-mei=晃弘 aut-affil-num=3 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name=石森有 kn-aut-sei=石森 kn-aut-mei=有 aut-affil-num=4 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name=花元克巳 kn-aut-sei=花元 kn-aut-mei=克巳 aut-affil-num=5 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name=山岡聖典 kn-aut-sei=山岡 kn-aut-mei=聖典 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=4 en-affil= kn-affil=独立行政法人　日本原子力研究開発機構人形峠環境技術センター affil-num=5 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=6 en-affil= kn-affil=岡山大学大学院保健学研究科 en-keyword=new radon exposure device kn-keyword=new radon exposure device en-keyword=radon inhalation kn-keyword=radon inhalation en-keyword=antioxidative function kn-keyword=antioxidative function en-keyword=superoxide dismutase kn-keyword=superoxide dismutase en-keyword=catalase kn-keyword=catalase en-keyword=lipid peroxide kn-keyword=lipid peroxide en-keyword=active oxygen kn-keyword=active oxygen en-keyword=mouse kn-keyword=mouse en-keyword=radon-222 kn-keyword=radon-222 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=1 article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Basic Study on Positive Effects of Radon Inhalation on Pet's Health kn-title=ラドン吸入がペットの健康改善に及ぼす効果に関する基礎的検討 en-subtitle= kn-subtitle= en-abstract=Radon inhalation using our radon exposure device activated anti-oxidative function in some organs of mouse. To assess the possibility of its application to veterinary care, healthy dogs and cats with chronic renal failure were inhaled radon at a concentration of 5500Bq/m3 for 30 minutes every 2 days for 30 days. In result, radon inhalation within a relatively long time period significantly decreased the triglyceride level of dogs. On the other hand, some cats increased the volume of drinking water by radon inhalation and the creatinine level in blood of these cats was decreased to normal level. These findings suggest that radon inhalation may have curative properties against chronic renal failure. kn-abstract=著者らは今までに，共同開発したラドン吸入装置を用いマウスにラドン吸入をさせた場合，諸臓器中の抗酸化機能が亢進する可能性などを明らかにしてきた。本研究では，ラドン吸入の獣医療への応用の可能性について新たに検討するため，健常なイヌ5頭(オス：2(1，9才)，メス：3(1〜5才))及び慢性腎不全症のネコ8頭(オス：3(2〜6才)，メス：5(5〜7才))を対象に基礎的な検討をした。すなわち，約5500Bq/m3のラドンを1回30分で隔日に30日間(計15回)それぞれ吸入させた。その結果，イヌにおいて，中性脂肪が減少する可能性が示された。また，その効果は吸入開始20〜30日後に現れることも示唆できた。他方，ネコにおいて，飲水量が改善し血清中クレアチニンが基準値内に減少する症例がみられるなど，慢性腎不全症に対し一定の効果が期待できる可能性が示唆された。 en-copyright= kn-copyright= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name=片岡隆浩 kn-aut-sei=片岡 kn-aut-mei=隆浩 aut-affil-num=1 ORCID= en-aut-name=TokunagaRikizo en-aut-sei=Tokunaga en-aut-mei=Rikizo kn-aut-name=徳永力三 kn-aut-sei=徳永 kn-aut-mei=力三 aut-affil-num=2 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name=迫田晃弘 kn-aut-sei=迫田 kn-aut-mei=晃弘 aut-affil-num=3 ORCID= en-aut-name=KawabeAtsushi en-aut-sei=Kawabe en-aut-mei=Atsushi kn-aut-name=川辺睦 kn-aut-sei=川辺 kn-aut-mei=睦 aut-affil-num=4 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name=花元克巳 kn-aut-sei=花元 kn-aut-mei=克巳 aut-affil-num=5 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name=山岡聖典 kn-aut-sei=山岡 kn-aut-mei=聖典 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=2 en-affil= kn-affil=南富士ケンネル附属動物病院 affil-num=3 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=4 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=5 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=6 en-affil= kn-affil=岡山大学大学院保健学研究科 en-keyword=dog kn-keyword=dog en-keyword=cat kn-keyword=cat en-keyword=radon inhalation kn-keyword=radon inhalation en-keyword=serum biochemistry kn-keyword=serum biochemistry en-keyword=chronic renal failure kn-keyword=chronic renal failure END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=5 article-no= start-page=231 end-page=241 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120529 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Inhibitory Effects of Pre and Post Radon Inhalation on Carbon Tetrachloride-induced Oxidative Damage in Mouse Organs en-subtitle= kn-subtitle= en-abstract= kn-abstract=Radon inhalation activates antioxidative functions in some organs of mice. We examined the prevention effects of pre radon inhalation and the alleviation effects of post radon inhalation on carbon tetrachloride (CCl4)-induced oxidative damage in the brain, heart, lung, liver, and kidney of mice. In addition, we compared the effect of pre and post radon inhalation on oxidative damage. Mice inhaled radon at a concentration of 18000Bq/m3 for 6hrs before or after CCl4 administration. As a result, the total glutathione(t-GSH) contents and catalase(CAT) activities in the brain, heart, lung, liver, and kidney and superoxide dismutase(SOD) activities in the heart and lung were significantly higher in pre and post radon-inhaled mice than in mice treated with only CCl4. Pre radon inhalation inhibited and post radon inhalation reduced lipid peroxidation induced by CCl4. In addition, there were no significant differences in lipid peroxide(LPO) levels in the brain, heart, lung, liver, and kidney between pre and post radon-inhaled mice. These findings suggested that post radon inhalation has the same effects as pre radon inhalation against CCl4-induced oxidative damage in the brain, heart, lung, liver, and kidney. en-copyright= kn-copyright= en-aut-name=NishiyamaYuichi en-aut-sei=Nishiyama en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TeraokaJunichi en-aut-sei=Teraoka en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=4 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=5 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=6 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=carbon tetrachloride kn-keyword=carbon tetrachloride en-keyword=oxidative damage kn-keyword=oxidative damage en-keyword=pre or post radon inhalation kn-keyword=pre or post radon inhalation en-keyword=antioxidative function kn-keyword=antioxidative function END