フルテキストURL GGI_16_4_440.pdf fig.pdf
著者 Tokuchi, Ryo| Hishikawa, Nozomi| Matsuzono, Kosuke| Takao, Yoshiki| Wakutani, Yosuke| Sato, Kota| Kono, Syoichiro| Ohta, Yasuyuki| Deguchi, Kentaro| Yamashita, Toru| Abe, Koji|
抄録 AIM: The aim of the present study was to compare the effects of a galantamine only therapy and a combination therapy with galantamine plus ambulatory cognitive rehabilitation for Alzheimer's disease patients. METHODS: For this retrospective cohort study, we enrolled 86 patients with Alzheimer's disease, dividing them into two groups - a galantamine only group (group G, n = 45) and a combination with galantamine plus ambulatory rehabilitation group (group G + R, n = 41). The present cognitive rehabilitation included a set of physical therapy, occupational therapy and speech therapy for 1-2 h once or twice a week. We compared the Mini-Mental State Examination and Frontal Assessment Battery for cognitive assessment, and Geriatric Depression Scale, Apathy Scale, and Abe's Behavioral and Psychological Symptoms of Dementia score for affective assessment in two groups over 6 months. RESULTS: The baseline Mini-Mental State Examination score was 20.2 and 18.7 in groups G and G + R, respectively. Other baseline data (Frontal Assessment Battery, Geriatric Depression Scale, Apathy Scale, and Abe's Behavioral and Psychological Symptoms of Dementia) were not different between the two groups. Although group G kept all the scores stable until 6 months of the treatment, the Apathy Scale score showed a significant improvement in group G + R as early as 3 months, followed by the Mini-Mental State Examination and Frontal Assessment Battery improvements at 6 months (*P = 0.04 and *P = 0.02, respectively). The Geriatric Depression Scale and Abe's Behavioral and Psychological Symptoms of Dementia did not show any changes. CONCLUSION: The combination therapy of galantamine plus ambulatory cognitive rehabilitation showed a superior benefit both on cognitive and affective functions than galantamine only therapy in Alzheimer's disease patients.
キーワード Alzheimer's disease affective function cognitive function combination therapy galantamine
備考 This is an Accepted Manuscript of an article published by Wiley
発行日 2016-04
出版物タイトル Geriatrics & Gerontology International
16巻
4号
出版者 Japan Geriatrics Society
開始ページ 440
終了ページ 445
ISSN 1444-1586
NCID AA1155729X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 25952367
DOI 10.1111/ggi.12488
Web of Sience KeyUT 000373611800005
関連URL isVersionOf https://doi.org/10.1111/ggi.12488
フルテキストURL CGI_17_11_1843.pdf fig.pdf
著者 Ohta, Yasuyuki| Darwish, Mohamed| Hishikawa, Nozomi| Yamashita, Toru| Sato, Kota| Takemoto, Mami| Abe, Koji|
抄録 AIM: To evaluate the therapeutic effects of switching from one acetylcholinesterase inhibitor (ChEI), donepezil, galantamine or rivastigmine, to another in Alzheimer's disease patients. METHODS: We retrospectively enrolled 171 Alzheimer's disease patients, whose ChEI medication was changed. The patients were evaluated on three major aspects of dementia - cognitive, affective and activities of daily living (ADL) measures - at 6 months (M) before the drug switch, at the time of drug switch (baseline), and at 3 M and 6 M after the drug switch. RESULTS: The doses of the three ChEI were significantly lower at 6 M after the switch compared with the pre-switch doses. Improvements in apathy were found at 3 M when switching from donepezil to galantamine, but not to rivastigmine, but this switch had adverse effects on ADL. Improvements in cognitive scores at 3 M were also found when switching from galantamine to rivastigmine, but not to donepezil. However, both of these changes improved Abe's Behavioral and Psychological Symptoms of Dementia scores (ABS), except ADL. Switching from rivastigmine to donepezil worsened ABS at 6 M, but preserved cognitive and ADL scores. CONCLUSIONS: The present study suggests that despite a relatively lower dose of ChEI after the switch, switching from donepezil or rivastigmine preserved cognitive functions for at least 6 M. Switching from galantamine to rivastigmine improved Mini-Mental State Examination and ABS at 3 M, but did not improve ADL scores. Geriatr Gerontol Int 2017; 17: 1843-1848.
キーワード Alzheimer's disease donepezil drug switch galantamine rivastigmine
備考 This is an Accepted Manuscript of an article published by Wiley
発行日 2017-11
出版物タイトル Geriatrics & Gerontology International
17巻
11号
出版者 Japan Geriatrics Society
開始ページ 1843
終了ページ 1848
ISSN 1444-1586
NCID AA1155729X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28060449
DOI 10.1111/ggi.12971
Web of Sience KeyUT 000416330000009
関連URL isVersionOf https://doi.org/10.1111/ggi.12971
フルテキストURL GGI_17_5_722.pdf
著者 Hishikawa, Nozomi| Fukui, Yusuke| Sato, Kota| Yamashita, Toru| Ohta, Yasuyuki| Abe, Koji|
抄録 AIM: The number of people with dementia is rapidly increasing as populations around the world age. It is important to grasp the characteristic features of mild cognitive impairment (MCI) for early detection and prevention of dementia. METHODS: We examined 408 individuals recruited from a health checkup for metabolic syndrome, which comprised three groups: normal (n = 325), MCI (n = 55) and apparent cognitive decline (ACD; n = 28). We compared cognitive/affective functions and exercise/hobby habits with assessments of vascular risk factors and results from computerized touch-panel tests. RESULTS: Among the 408 individuals, 93.1% showed normal scores on the Mini-Mental State Examination, and 6.9% had ACD. Among the normal Mini-Mental State Examination participants, 14.5% had MCI (13.5% of all participants). The three groups of participants showed significant differences in age, education, systolic blood pressure, glycosylated hemoglobin and high-density lipoprotein cholesterol level. Even within the normal range, those in the MCI group showed significantly lower cognitive function than those in the normal group. Scores on the Geriatric Depression Scale were greater in the MCI group, and "day-night reversal" was worse in the ACD group. Scores on touch-panel screening tests were significantly worse in the MCI and ACD groups than in the normal group. Participants showed better cognitive and affective function if they exercised regularly or had hobbies. CONCLUSIONS: Incidental MCI and ACD had prevalences of 13.5% and 6.9%, respectively, in the population-based study. Participants with these conditions showed cognitive/affective decline and impairment on computerized touch-panel tests in relation to vascular risk factors and exercise/hobbies. Geriatr Gerontol Int 2017; 17: 722-729.
キーワード apparent cognitive decline cognitive/affective functions general population mild cognitive impairment risk factors
備考 This is an Accepted Manuscript of an article published by Wiley This fulltext will be available in May 2018
発行日 2017-05
出版物タイトル Geriatrics & Gerontology International
17巻
5号
出版者 Japan Geriatrics Society
開始ページ 722
終了ページ 729
ISSN 1444-1586
NCID AA1155729X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 27150587
DOI 10.1111/ggi.12778
Web of Sience KeyUT 000403931900006
関連URL isVersionOf https://doi.org/10.1111/ggi.12778
フルテキストURL GGI_16_4_458.pdf
著者 Hishikawa, Nozomi| Fukui, Yusuke| Sato, Kota| Kono, Syoichiro| Yamashita, Toru| Ohta, Yasuyuki| Deguchi, Kentaro| Abe, Koji|
抄録 AIMS: The world is rapidly aging, and is facing an increase of late-elderly dementia patients. It is important to investigate the characteristic features of late-elderly dementia in a super-aged country. METHODS: We examined 1554 patients with cognitive decline in Department of Neurology, Okayama University Hospital, Okayama, Japan, divided into three subgroups according to the age: young-elderly (age ≤64 years), middle-elderly (age 65-74 years) and late-elderly (age 75 years), and investigated the cognitive, affective and activities of daily living functions (ADL), especially in late-elderly patients compared with young-elderly and middle-elderly patients. RESULTS: Among 1554 patients, Alzheimer's disease dominated at 62%, and age-dependently increased up to 69% in the late-elderly group. The total scores of four cognitive tests were significantly worse with aging for specific subscales of orientation, recall, visual retention, word fluency and so on. In contrast, total scores of the affective tests showed only an increase in the apathy scale in the late-elderly group. Each subgroup showed depressive/depression in 63.2-55.2%, and apathy in 44.2-54.8%. Furthermore, instrumental ADL items significantly deteriorated in the late-elderly group, which statistically correlated with Mini-Mental State Examination score. CONCLUSIONS: These results show that the late-elderly group is characterized by significant cognitive declines, increasing apathy, and instrumental ADL decrease. The cognitive decline may be related to such affective and ADL declines.
キーワード affective functions cognitive function daily living function late-elderly dementia super-aged country
備考 This is an Accepted Manuscript of an article published by Wiley
発行日 2016-04
出版物タイトル Geriatrics & Gerontology International
16巻
4号
出版者 Japan Geriatrics Society
開始ページ 458
終了ページ 465
ISSN 1444-1586
NCID AA1155729X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 25952646
DOI 10.1111/ggi.12492
Web of Sience KeyUT 000373611800007
関連URL isVersionOf https://doi.org/10.1111/ggi.12492
フルテキストURL GGI_17_11_1991.pdf
著者 Fukui, Yusuke| Hishikawa, Nozomi| Ichinose, Jin| Sato, Kota| Nakano, Yumiko| Morihara, Ryuta| Ohta, Yasuyuki| Yamashita, Toru| Abe, Koji|
抄録 AIM:To examine the clinical effect of four antidementia drugs (donepezil, galantamine, rivastigmine and memantine) in Alzheimer's disease patients who were divided into subgroups based on their periventricular hyperintensity (PVH) severity. METHODS: A total of 551 Alzheimer's disease patients (201 men and 350 women) were divided into four subgroups based on their PVH severity (0-III). They received monotherapy for 12 months. We compared the clinical effects at the baseline, and at 3, 6 and 12 months after initiation. RESULTS: The baseline age became higher with PVH grades, and the Mini-Mental State Examination and Hasegawa Dementia Scale-Revised showed a decrease that was dependent on white matter severity. Although the PVH 0 subgroup showed stable cognitive, affective and ADL functions until 12 months in all four drug groups, the PVH I subgroup showed an improved Apathy Scale from the baseline in response to memantine at 3 and 9 months (P < 0.05), and galantamine at 9 months (P < 0.01). In the PVH II subgroup, the Mini-Mental State Examination showed a significant improvement from the baseline in response to galantamine (P < 0.05) at 9 months and Hasegawa Dementia Scale-Revised (P < 0.05) at 3 months. In the PVH III subgroup, cognitive and affective functions were preserved in all four drug groups until 12 months, but activities of daily living deteriorated in the riverstigmine group at 6 and 12 months (P < 0.05). CONCLUSIONS: The present study shows that these four drugs showed sensitivity dependent on white matter severity that clinically affected cognitive, affective and activities of daily living functions. Geriatr Gerontol Int 2017; 17: 1991-1999.
キーワード Alzheimer's disease antidementia drug magnetic resonance imaging periventricular hyperintensity white matter lesions
備考 This is an Accepted Manuscript of an article published by Wiley This fulltext will be available in Nov 2018
発行日 2017-11
出版物タイトル Geriatrics & Gerontology International
17巻
11号
出版者 Japan Geriatrics Society
開始ページ 1991
終了ページ 1999
ISSN 1444-1586
NCID AA1155729X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28276131
DOI 10.1111/ggi.13007
Web of Sience KeyUT 000416330000029
関連URL isVersionOf https://doi.org/10.1111/ggi.13007