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ID 44370
フルテキストURL
著者
Hanaya, Tadashi Department of Chemistry, Faculty of Science, Okayama University
Torigoe, Kiyoshi Department of Chemistry, Faculty of Science, Okayama University
Soranaka, Kazuyuki Department of Chemistry, Faculty of Science, Okayama University
Fujita, Hiroshi Department of Chemistry, Faculty of Science, Okayama University
Yamamoto, Hiroshi School of Pharmacy, Shujitsu University
Pfleiderer, Wolfgang Fachbereich Chemie, Universität Konstanz
抄録
N(2)-(N,N-Dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]-1',2'-di-O (trimethylsilyl)biopterin (4) was prepared from biopterin (1a, 86% overall yield) in 5 steps. Glycosylation of 4 with 1,2,3,5-tetra-O-acetyl-β D-ribofuranose (5a) and its 2,3,5-tri-O-benzoyl analog (5b) respectively afforded the corresponding 2'-O-(2,3,5-tri-Oacetyl- and 2,3,5-tri-O-benzoyl-β-D ribofuranosyl)biopterin derivatives (6a, 42% and 6b, 60%) as major products. Removal of the protecting groups of 6b provided 2'-O-(β-D-ribofuranosyl)biopterin (1c, 87% overall yield) in 3 steps.
キーワード
biopterin D-riboside
pterin glycoside
glycosylation
protecting groups
発行日
2008-09
出版物タイトル
Pteridines
19巻
3号
出版者
International Society of Pteridinology
開始ページ
72
終了ページ
78
ISSN
0933-4807
資料タイプ
学術雑誌論文
オフィシャル URL
http://www.pteridines.sk/center.php?act=V&volId=119
言語
English
著作権者
Copyright © International Society of Pteridinology
論文のバージョン
publisher
査読
有り
Web of Sience KeyUT