Hindawi Publishing Corporation
Acta Medica Okayama
2012
2012
Theoretical Study on the Detection of Tilted Lipid Bilayers Using Surface Plasmon Resonance Techniques
EN
Koyo
Watanabe
Koji
Matsuura
Effective refractive indices detected using surface plasmon resonance techniques are calculated as a function of the tilt angle of lipid bilayers in a multilayered model. The changes in the effective refractive indices are derived from the shift of an excitation angle of surface plasmon. To obtain effective refractive index plots, we determined refractive index changes in the lipid bilayers with 3 and 5 nm thicknesses as a function of tilt angle and obtained a relationship between the effective refractive index and tilt angle. We also showed that the effective refractive index depended on the lipid bilayers thickness and anisotropic permittivities, which vary with interchain distance.
No potential conflict of interest relevant to this article was reported.
Hindawi Publishing Corporation
Acta Medica Okayama
2013
2013
Dual Antiplatelet Therapy Can Be Discontinued at Three Months after Implantation of Zotarolimus-Eluting Stent in Patients with Coronary Artery Disease
EN
Tadashi
Wada
Makoto
Nakahama
Hironobu
Toda
Atsuyuki
Watanabe
Katsushi
Hashimoto
Ritsuko
Terasaka
Kazufumi
Nakamura
Nobuyuki
Yamada
Hiroshi
Ito
Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention increases the risk of bleeding. We studied the safety and clinical outcomes of switching from DAPT to aspirin monotherapy at 3 months after ZES implantation. We retrospectively evaluated 168 consecutive patients with coronary artery disease who had been implanted with a ZES from June 2009 through March 2010. After excluding 40 patients according to exclusion criteria such as myocardial infarction, 128 patients were divided into a 3-month DAPT group (67 patients, 88 lesions) and a 12-month conventional DAPT group (61 patients, 81 lesions). Coronary angiographic followup and clinical followup were conducted at more than 8 months and at 12 months after ZES implantation, respectively. Minor and major bleeding events, stent thrombosis (ST), and major adverse cardiac events (MACE) (death, myocardial infarction, cerebrovascular accident, target lesion revascularization, and target vessel revascularization) were evaluated. There were no statistically significant differences in the incidences of ST and MACE between the two groups. The incidence of bleeding events was significantly lower in the 3-month group than in the 12-month group (1.5% versus 11.5%, ). DAPT can be safely discontinued at 3 months after ZES implantation, which reduces bleeding risk.
No potential conflict of interest relevant to this article was reported.
Hindawi Publishing Corporation
Acta Medica Okayama
2012
2012
Activation of Biodefense System by Low-Dose Irradiation or Radon Inhalation and Its Applicable Possibility for Treatment of Diabetes and Hepatopathy
11
11
EN
Takahiro
Kataoka
Kiyonori
Yamaoka
Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase. We studied the possibility for alleviation of oxidative damage, such as diabetes and nonalcoholic liver disease. Results show that low-dose ƒÁ-irradiation increases SOD activity and protects against alloxan diabetes. Prior or post-low-dose X- or ƒÁ-irradiation increases antioxidative functions in livers and inhibits ferric nitrilotriacetate and carbon tetrachloride-induced (CCl<sub>4</sub>) hepatopathy. Moreover, radon inhalation also inhibits CCl<sub>4</sub>-induced hepatopathy. It is highly possible that low-dose irradiation including radon inhalation activates the biodefence systems and, therefore, contributes to preventing or reducing reactive oxygen species-related diabetes and nonalcoholic liver disease, which are thought to involve peroxidation.
No potential conflict of interest relevant to this article was reported.