ID | 61029 |
フルテキストURL | |
著者 |
Akashi, Makoto
The Research Institute for Time Studies, Yamaguchi University
Sogawa, Reimi
Department of Clinical Genetics and Genomic Medicine, Okayama University Hospital
Matsumura, Ritsuko
The Research Institute for Time Studies, Yamaguchi University
Nishida, Atsuhiro
The Research Institute for Time Studies, Yamaguchi University
Nakamura, Rino
The Research Institute for Time Studies, Yamaguchi University
Tokuda, Isao T.
Department of Mechanical Engineering, Ritsumeikan University
Node, Koichi
Department of Cardiovascular Medicine, Saga University
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抄録 | Background
Individuals with typical circadian rhythm sleep-wake disorders (CRSWDs) have a habitual sleep timing that is desynchronized from social time schedules. However, it is possible to willfully force synchronisation against circadian-driven sleepiness, which causes other sleep problems. This pathology is distinguishable from typical CRSWDs and is referred to here as latent CRSWD (LCRSWD). Conventional diagnostic methods for typical CRSWDs are insufficient for detecting LCRSWD because sufferers have an apparently normal habitual sleep timing.
Methods
We first evaluated the reliability of circadian phase estimation based on clock gene expression using hair follicles collected at three time points without sleep interruption. Next, to identify detection criteria for LCRSWD, we compared circadian and sleep parameters according to estimated circadian phases, at the group and individual level, between subjects with low and high Pittsburgh Sleep Quality Index (PSQI) scores. To validate the reliability of identified detection criteria, we investigated whether the same subjects could be reproducibly identified at a later date and whether circadian amelioration resulted in sleep improvement.
Findings
We successfully validated the reliability of circadian phase estimation at three time points and identified potential detection criteria for individuals with LCRSWD attributed to delayed circadian-driven sleepiness. In particular, a criterion based on the interval between the times of the estimated circadian phase of clock gene expression and getting out of bed on work or school days was promising. We also successfully confirmed the reproducibility of candidate screening and sleep improvement by circadian amelioration, supporting the reliability of the detection criteria.
Interpretation
Although several limitations remain, our present study demonstrates a promising prototype of a detection method for LCRSWD attributed to delayed circadian-driven sleepiness. More extensive trials are needed to further validate this method.
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キーワード | Circadian rhythm sleep-wake disorder
Circadian clock
Hair follicle
Clock gene
Period3
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発行日 | 2020-12
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出版物タイトル |
EBioMedicine
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巻 | 62巻
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出版者 | Elsevier
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開始ページ | 103080
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ISSN | 2352-3964
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2020 The Author(s).
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1016/j.ebiom.2020.103080
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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