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ID 60856
フルテキストURL
fig1-10.pdf 4.95 MB
著者
Sato, Tadasu Division of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry
Yajima, Takehiro Division of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry
Fujita, Masako Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences
Kobashi, Motoi Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Ichikawa, Hiroyuki Division of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry
Yoshida, Ryusuke Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Mitoh, Yoshihiro Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
抄録
Orexin (OX), which regulates sleep and wakefulness and feeding behaviors has 2 isoforms, orexin-A and -B (OXA and OXB). In this study, the distribution of OXA and OXB was examined in the rat superior salivatory nucleus (SSN) using retrograde tracing and immunohistochemical and methods. OXA- and OXB-immunoreactive (-ir) nerve fibers were seen throughout the SSN. These nerve fibers surrounded SSN neurons retrogradely labeled with Fast blue (FB) from the corda-lingual nerve. FB-positive neurons had pericellular OXA- (47.5%) and OXB-ir (49.0%) nerve fibers. Immunohistochemistry for OX receptors also demonstrated the presence of OX1R and OX2R in FB-positive SSN neurons. The majority of FB-positive SSN neurons contained OX1R- (69.7%) or OX2R-immunoreactivity (57.8%). These neurons had small and medium-sized cell bodies. In addition, half of FB-positive SSN neurons which were immunoreactive for OX1R (47.0%) and OX2R (52.2%) had pericellular OXA- and OXB-ir nerve fibers, respectively. Co-expression of OX1R- and OX2R was common in FB-positive SSN neurons. The present study suggests a possibility that OXs regulate the activity of SSN neurons through OX receptors.
キーワード
Orexin
Orexin receptor
Superior salivatory nucleus
Preganglionic neuron
Chorda-lingual nerve
Immunohistochemistry
発行日
2020-11
出版物タイトル
Autonomic Neuroscience
228巻
出版者
Elsevier
開始ページ
102712
ISSN
1566-0702
NCID
AA11470577
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
論文のバージョン
author
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1016/j.autneu.2020.102712
ライセンス
https://creativecommons.org/licenses/by-nc-nd/4.0/
助成機関名
日本学術振興会
助成番号
25462887
18K11022