ID | 60856 |
フルテキストURL | |
著者 |
Sato, Tadasu
Division of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry
Yajima, Takehiro
Division of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry
Fujita, Masako
Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences
Kobashi, Motoi
Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences
Kaken ID
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Ichikawa, Hiroyuki
Division of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry
Yoshida, Ryusuke
Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
researchmap
Mitoh, Yoshihiro
Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences
Kaken ID
publons
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抄録 | Orexin (OX), which regulates sleep and wakefulness and feeding behaviors has 2 isoforms, orexin-A and -B (OXA and OXB). In this study, the distribution of OXA and OXB was examined in the rat superior salivatory nucleus (SSN) using retrograde tracing and immunohistochemical and methods. OXA- and OXB-immunoreactive (-ir) nerve fibers were seen throughout the SSN. These nerve fibers surrounded SSN neurons retrogradely labeled with Fast blue (FB) from the corda-lingual nerve. FB-positive neurons had pericellular OXA- (47.5%) and OXB-ir (49.0%) nerve fibers. Immunohistochemistry for OX receptors also demonstrated the presence of OX1R and OX2R in FB-positive SSN neurons. The majority of FB-positive SSN neurons contained OX1R- (69.7%) or OX2R-immunoreactivity (57.8%). These neurons had small and medium-sized cell bodies. In addition, half of FB-positive SSN neurons which were immunoreactive for OX1R (47.0%) and OX2R (52.2%) had pericellular OXA- and OXB-ir nerve fibers, respectively. Co-expression of OX1R- and OX2R was common in FB-positive SSN neurons. The present study suggests a possibility that OXs regulate the activity of SSN neurons through OX receptors.
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キーワード | Orexin
Orexin receptor
Superior salivatory nucleus
Preganglionic neuron
Chorda-lingual nerve
Immunohistochemistry
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発行日 | 2020-11
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出版物タイトル |
Autonomic Neuroscience
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巻 | 228巻
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出版者 | Elsevier
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開始ページ | 102712
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ISSN | 1566-0702
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NCID | AA11470577
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | author
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1016/j.autneu.2020.102712
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ライセンス | https://creativecommons.org/licenses/by-nc-nd/4.0/
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助成機関名 |
日本学術振興会
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助成番号 | 25462887
18K11022
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