ID | 48972 |
フルテキストURL | |
著者 |
Matsuura, Koji
Research Core for Interdisciplinary Sciences, Okayama University
Kaken ID
publons
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Hayashi, Nobuyoshi
Okayama Couples Clinic
Kuroda, Yuka
Research Core for Interdisciplinary Sciences, Okayama University
Takiue, Chisato
Okayama Couples Clinic
Hirata, Rei
Okayama Couples Clinic
Takenami, Mami
Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Aoi, Yoko
Okayama Couples Clinic
Yoshioka, Nanako
Okayama Couples Clinic
Habara, Toshihiro
Okayama Couples Clinic
Mukaida, Tetsunori
Hiroshima HART Clinic
Naruse, Keiji
Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
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抄録 | Mammalian embryos experience not only hormonal but also mechanical stimuli, such as shear stress, compression and friction force in the Fallopian tube before nidation. In order to apply mechanical stimuli to embryos in a conventional IVF culture system, the tilting embryo culture system (TECS) was developed. The observed embryo images from the TECS suggest that the velocities and shear stresses of TECS embryos are similar to those experienced in the oviduct. Use of TECS enhanced the development rate to the blastocyst stage and significantly increased the cell number of mouse blastocysts (P < 0.05). Although not statistically significant, human thawed embryos showed slight improvement in development to the blastocyst stage following culture in TECS compared with static controls. Rates of blastocyst formation following culture in TECS were significantly improved in low-quality embryos and those embryos cultured under suboptimal conditions (P < 0.05). The TECS is proposed as a promising approach to improve embryo development and blastocyst formation by exposing embryos to mechanical stimuli similar to those in the Fallopian tube.
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キーワード | blastocyst
embryo development
mechanical stimuli
shear stress
tilting embryo culture system
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発行日 | 2010-03
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出版物タイトル |
Reproductive BioMedicine Online
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巻 | 20巻
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号 | 3号
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出版者 | Elsevier
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開始ページ | 358
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終了ページ | 364
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ISSN | 1472-6483
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資料タイプ |
学術雑誌論文
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プロジェクト |
異分野融合先端研究コア
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オフィシャル URL | http://www.sciencedirect.com/science/article/pii/S1472648309002727
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言語 |
英語
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著作権者 | Copyright © 2009 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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論文のバージョン | author
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査読 |
有り
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DOI | |
PubMed ID | |
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