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Adachi, R. Laboratory of Bioscience, Faculty of Engineering, Iwate University
Takaya, T. Division of Translational Research, Kyoto Medical Center, National Hospital Organization
Kuriyama, K. Office of Space Flight and Operations, Japan Aerospace Exploration Agency
Higashibata, A. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
Ishioka, N. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
Kagawa, H. Biomolecular Science, Graduate School of Natural Science and Technology, Okayama University
We have investigated the effect of microgravity during spaceflight on body-wall muscle fiber size and muscle proteins in the paramyosin mutant of Caenorhabditis elegans. Both mutant and wild-type strains were subjected to 10 days of microgravity during spaceflight and compared to ground control groups. No significant change in muscle fiber size or quantity of the protein was observed in wild-type worms; where as atrophy of body-wall muscle and an increase in thick filament proteins were observed in the paramyosin mutant unc-15(e73) animals after spaceflight. We conclude that the mutant with abnormal muscle responded to microgravity by increasing the total amount of muscle protein in order to compensate for the loss of muscle function.
Myosin heavy chain
Published with permission from the copyright holder.
This is a author's copy,as published in Advances in Space Research , 2008, volume 41, issue 5, pp816-823.
Publisher URL: http://dx.doi.org/10.1016/j.asr.2007.10.016
Copyright © 2007 COSPAR. Published by Elsevier Ltd. All rights reserved.
Advances in Space Research
© 2007 COSPAR Published by Elsevier Ltd.
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