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ID 32999
フルテキストURL
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著者
Adachi, R. Laboratory of Bioscience, Faculty of Engineering, Iwate University
Takaya, T. Division of Translational Research, Kyoto Medical Center, National Hospital Organization
Kuriyama, K. Office of Space Flight and Operations, Japan Aerospace Exploration Agency
Higashibata, A. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
Ishioka, N. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
Kagawa, H. Biomolecular Science, Graduate School of Natural Science and Technology, Okayama University
抄録
We have investigated the effect of microgravity during spaceflight on body-wall muscle fiber size and muscle proteins in the paramyosin mutant of Caenorhabditis elegans. Both mutant and wild-type strains were subjected to 10 days of microgravity during spaceflight and compared to ground control groups. No significant change in muscle fiber size or quantity of the protein was observed in wild-type worms; where as atrophy of body-wall muscle and an increase in thick filament proteins were observed in the paramyosin mutant unc-15(e73) animals after spaceflight. We conclude that the mutant with abnormal muscle responded to microgravity by increasing the total amount of muscle protein in order to compensate for the loss of muscle function.
キーワード
Spaceflight
Microgravity
Myosin heavy chain
Paramyosin
C. elegans
Mutation
備考
Published with permission from the copyright holder.
This is a author's copy,as published in Advances in Space Research , 2008, volume 41, issue 5, pp816-823.
Publisher URL: http://dx.doi.org/10.1016/j.asr.2007.10.016
Copyright © 2007 COSPAR. Published by Elsevier Ltd. All rights reserved.
発行日
2008
出版物タイトル
Advances in Space Research
41巻
5号
出版者
Elsevier Ltd.
開始ページ
816
終了ページ
823
ISSN
0273-1177
NCID
AA10636539
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2007 COSPAR Published by Elsevier Ltd.
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT
Submission Path
biology_general/38