このエントリーをはてなブックマークに追加
ID 34122
フルテキストURL
著者
Kurauchi, Tomomi Department of Ophthalmology, Okayama University Graduate School of Medicine and Dentistry
Yokota, Kenji Department of Bacteriology, Okayama University Graduate School of Medicine and Dentistry
Matsuo, Toshihiko Department of Ophthalmology, Okayama University Graduate School of Medicine and Dentistry
Fujinami, Yoshihito Department of Ophthalmology, Okayama University Graduate School of Medicine and Dentistry
Isogai, Emiko Department of Preventive Dentistry, Health Sciences University of Hokkaido
Isogai, Hiroshi Division of Animal Experimentation, Sapporo Medical University
Ohtsuki, Hiroshi Department of Ophthalmology, Okayama University Graduate School of Medicine and Dentistry
Oguma, Keiji Department of Bacteriology, Okayama University Graduate School of Medicine and Dentistry
抄録
Immune reactions against microorganisms play an important pathogenic role in Adamantiades-Behçet’s disease (ABD). We had previously obtained Streptococcus sanguinis (strain BD113-20) isolated from the oral cavity of patients with ABD. To investigate the pathogenesis of this isolate, we examined neutrophil 5 reactions and level of cytokine production by lymphocytes after stimulation with the strain. The reactions of neutrophils were examined by chemiluminescence assay using whole blood. The amounts of interferon gamma (IFN-g) and interleukin (IL)-4, IL-8, IL-10, and IL-12 produced by peripheral blood mononuclear cells (PBMCs) were measured by ELISA. 10 Strain BD113-20 activated neutrophils from patients with ABD and healthy volunteers, and, in addition it increased IFN-g production by lymphocytes. Lymphocyte from the patients with ABD showed a dominant T helper 1 (Th-1) immune response. Results indicated that both bacterial stimulation and host hypersensitivity might be involved in the symptoms and pathogenesis of ABD.
キーワード
Adamantiades-Behcet's disease
Streptococcus sanguinis
neutrophil
chemiluminescence
IL-8
T helper-1
IFN-gamma
IL-12
備考
Digital Object Identifer:10.1016/j.femsim.2004.07.007
The Published with permission from the copyright holder. This is the author's copy, as published in FEMS Immunology and Medical Microbiology, February 2005, Volume 43, Issue 2, Pages 125-131.
Publisher URL:http://dx.doi.org/10.1016/j.femsim.2004.07.007
Direct access to Thomson Web of Science record
Copyright © 2004 Federation of European Microbiological Societies Published by Elsevier B.V. All rights reserved.
発行日
2005-02-01
出版物タイトル
FEMS Immunology and Medical Microbiology
43巻
2号
出版者
Elsevier B.V.
開始ページ
125
終了ページ
131
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
Federation of European Microbiological Societies. Published by Elsevier B.V.
査読
有り
DOI
Web of Sience KeyUT
Submission Path
microbiology_and_immunology/5