ID | 57889 |
フルテキストURL | |
著者 |
Ueki, Yushi
Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences
Saito, Ken
Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences
Iioka, Hidekazu
Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences
Sakamoto, Izumi
ACROSCALE Inc.
Kanda, Yasuhiro
Department of Immunology, Niigata University Graduate School of Medical and Dental Sciences
Sakaguchi, Masakiyo
Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
publons
researchmap
Horii, Arata
Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences
Kondo, Eisaku
Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences
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抄録 | Identifying the specific functional regulator of integrin family molecules in cancer cells is critical because they are directly involved in tumor invasion and metastasis. Here we report high expression of PLOD2 in oropharyngeal squamous cell carcinomas (SCCs) and its critical role as a stabilizer of integrin β1, enabling integrin β1 to initiate tumor invasion/metastasis. Integrin β1 stabilized by PLOD2-mediated hydroxylation was recruited to the plasma membrane, its functional site, and accelerated tumor cell motility, leading to tumor metastasis in vivo, whereas loss of PLOD2 expression abrogated it. In accordance with molecular analysis, examination of oropharyngeal SCC tissues from patients corroborated PLOD2 expression associated with integrin β1 at the invasive front of tumor nests. PLOD2 is thus implicated as the key regulator of integrin β1 that prominently regulates tumor invasion and metastasis, and it provides important clues engendering novel therapeutics for these intractable cancers.
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キーワード | Cancer
Molecular Biology
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発行日 | 2020-01-18
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出版物タイトル |
iScience
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巻 | 23巻
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号 | 2号
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出版者 | Cell Press
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開始ページ | 100850
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ISSN | 25890042
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2020 The Author(s).
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
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関連URL | isVersionOf https://doi.org/10.1016/j.isci.2020.100850
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ライセンス | http://creativecommons.org/licenses/by-nc-nd/4.0/
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Citation | Ueki Y, Saito K, Iioka H, et al. PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas. iScience. 2020;23(2):100850. doi:10.1016/j.isci.2020.100850
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助成機関名 |
日本学術振興会
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助成番号 | 24659170
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オープンアクセス(出版社) |
OA
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オープンアーカイブ(出版社) |
非OpenArchive
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