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ID 55411
フルテキストURL
Thumnail fig.pdf 202 KB
著者
Nishimura, Ryo Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University
Okuda, Kiyoshi Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University
抄録
There is increasing interest in the role of oxygen conditions in the microenvironment of organs because of the discovery of a hypoxia-specific transcription factor, namely hypoxia-inducible factor (HIF) 1. Ovarian function has several phases that change day by day, including ovulation, follicular growth and corpus luteum formation and regression. These phases are regulated by many factors, including pituitary hormones and local hormones, such as steroids, peptides and cytokines, as well as oxygen conditions. Hypoxia strongly induces angiogenesis because transcription of the potent angiogenic factor vascular endothelial growth factor (VEGF) is regulated by HIF1. Follicular development and luteal formation are accompanied by a marked increase in angiogenesis assisted by HIF1-VEGF signalling. Hypoxia is also one of the factors that induces luteolysis by suppressing progesterone synthesis and by promoting apoptosis of luteal cells. The present review focuses on recent studies of hypoxic conditions, as well as HIF1-regulated genes and proteins, in the regulation of ovarian function.
キーワード
angiogenesis
apoptosis
corpus luteum
follicular development
luteal formation
luteal regression
steroidogenesis
備考
This is an Accepted Manuscript of an article published by CSIRO Publishing
発行日
2015-05
出版物タイトル
Reproduction, Fertility and Development
28巻
10号
出版者
CSIRO Publishing
開始ページ
1479
終了ページ
1486
ISSN
1031-3613
NCID
AA10718189
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン
author
PubMed ID
DOI
Web of Sience KeyUT
関連URL
isVersionOf https://doi.org/10.1071/RD15010