ID | 53016 |
フルテキストURL | |
著者 |
Mizoo, Taeko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
Taira, Naruto
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
Kaken ID
publons
Nishiyama, Keiko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
Nogami, Tomohiro
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
Iwamoto, Takayuki
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
Motoki, Takayuki
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
publons
Shien, Tadahiko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
ORCID
Kaken ID
publons
researchmap
Matsuoka, Junji
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
Kaken ID
researchmap
Doihara, Hiroyoshi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
Kaken ID
researchmap
Ishihara, Setsuko
Okayama Saiseikai Gen Hosp, Dept Radiol
Kawai, Hiroshi
Okayama Rousai Hosp, Dept Breast Surg
Kawasaki, Kensuke
Kagawa Prefectural Canc Detect Ctr, Dept Breast Surg
Ishibe, Youichi
Mizushima Kyodo Hosp, Dept Breast Surg
Ogasawara, Yutaka
Dept Breast & Endocrinol Surg
Komoike, Yoshifumi
Kinki Univ Hosp, Fac Med
Miyoshi, Shinichiro
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
Kaken ID
publons
researchmap
|
抄録 | Background: Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were to validate the association between reported SNPs and breast cancer risk in the Japanese population and to evaluate the effects of SNP genotypes and lifestyle factors on breast cancer risk.
Methods: A case-control study in 472 patients and 464 controls was conducted from December 2010 to November 2011. Lifestyle was examined using a self-administered questionnaire. We analyzed 16 breast cancer-associated SNPs based on previous GWAS or candidate-gene association studies. Age or multivariate-adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were estimated from logistic regression analyses.
Results: High BMI and current or former smoking were significantly associated with an increased breast cancer risk, while intake of meat, mushrooms, yellow and green vegetables, coffee, and green tea, current leisure-time exercise, and education were significantly associated with a decreased risk. Three SNPs were significantly associated with a breast cancer risk in multivariate analysis: rs2046210 (per allele OR = 1.37 [95% CI: 1.11-1.70]), rs3757318 (OR = 1.33[1.05-1.69]), and rs3803662 (OR = 1.28 [1.07-1.55]). In 2046210 risk allele carriers, leisure-time exercise was associated with a significantly decreased risk for breast cancer, whereas current smoking and high BMI were associated with a significantly decreased risk in non-risk allele carriers.
Conclusion: In Japanese women, rs2046210 and 3757318 located near the ESR1 gene are associated with a risk of breast cancer, as in other Asian women. However, our findings suggest that exercise can decrease this risk in allele carriers.
|
キーワード | Japanese women
Asian
Breast cancer
Lifestyle
Leisure-time exercise
Parity
Single nucleotide polymorphisms
rs2046210
rs3757318
ESR1
|
発行日 | 2013-12-01
|
出版物タイトル |
BMC Cancer
|
巻 | 13巻
|
出版者 | BioMed Central Ltd.
|
ISSN | 1471-2407
|
資料タイプ |
学術雑誌論文
|
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52972
|
言語 |
英語
|
著作権者 | © 2013 Mizoo et al.; licensee BioMed Central Ltd.
|
論文のバージョン | publisher
|
査読 |
有り
|
DOI | |
Web of Science KeyUT |