フルテキストURL Mol_Cell_Biol_28_7_2391.pdf
著者 Eguchi, Takanori| Kubota, Satoshi| Kawata, Kazumi| Mukudai, Yoshiki| Uehara, Junji| Ohgawara, Toshihiro| Ibaragi, Soichiro| Sasaki, Akira| Kuboki, Takuo| Takigawa, Masaharu|
抄録  Matrix metalloproteinase 3 (MMP3) is well known as a secretory endopeptidase that degrades extracellular matrices. Recent reports indicated the presence of MMPs in the nucleus (A. J. Kwon et al., FASEB J. 18:690-692, 2004); however, its function has not been well investigated. Here, we report a novel function of human nuclear MMP3 as a trans regulator of connective tissue growth factor (CCN2/CTGF). Initially, we cloned MMP3 cDNA as a DNA-binding factor for the CCN2/CTGF gene. An interaction between MMP3 and transcription enhancer dominant in chondrocytes (TRENDIC) in the CCN2/CTGF promoter was confirmed by a gel shift assay and chromatin immunoprecipitation. The CCN2/CTGF promoter was activated by overexpressed MMP3, whereas a TRENDIC mutant promoter lost the response. Also, the knocking down of MMP3 suppressed CCN2/CTGF expression. By cytochemical and histochemical analyses, MMP3 was detected in the nuclei of chondrocytic cells in culture and also in the nuclei of normal and osteoarthritic chondrocytes in vivo. The nuclear translocation of externally added recombinant MMP3 and six putative nuclear localization signals in MMP3 also were shown. Furthermore, we determined that heterochromatin protein gamma coordinately regulates CCN2/CTGF by interacting with MMP3. The involvement of this novel role of MMP3 in the development, tissue remodeling, and pathology of arthritic diseases through CCN2/CTGF regulation thus is suggested.
発行日 2008-04
出版物タイトル Molecular and Cellular Biology
28巻
7号
出版者 American Society for Microbiology
開始ページ 2391
終了ページ 2413
ISSN 0270-7306
NCID AA10620925
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 18172013
DOI 10.1128/MCB.01288-07
Web of Sience KeyUT 000254181400025
関連URL isVersionOf https://doi.org/10.1128/MCB.01288-07
フルテキストURL Genome_Announc_5_41_e01030-17.pdf
著者 Seoane, Sergio| Hyodo, Kiwamu| Ueki, Shoko|
抄録 We report here the complete chloroplast genome sequences of seven strains of the bloom-forming raphidophyte Heterosigma akashiwo. These ~160-kb sequences contain 124 protein-, 6 rRNA-, and 34 tRNA-coding sequences. Notable sequence variations were observed among these seven sequenced and two previously characterized strains.
備考 This is an article published by American Society for Microbiology
発行日 2017-10
出版物タイトル Genome Annoucements
5巻
41号
出版者 American Society for Microbiology
開始ページ e01030-17
ISSN 2169-8287
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 29025932
DOI 10.1128/genomeA.01030-17
関連URL https://doi.org/10.1128/genomeA.01030-17
著者 Moritou, Yuki| Ikeda, Fusao| Takeuchi, Yasuto| Seki, Hiroyuki| Nanba, Shintaro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide|
発行日 2014-02
出版物タイトル Journal of Clinical Microbiology
52巻
2号
資料タイプ 学術雑誌論文
著者 Naha, Arindam| Pazhani, G. P.| Ganguly, Mou| Ghosh, Santanu| Ramamuranthy, T.| Nandy, Ranjan K.| Nair, G. Balakrish| Takeda, Yoshifumi| Mukhopadhyay, Asish K.|
発行日 2012-05
出版物タイトル Journal of Clinical Microbiology
50巻
5号
資料タイプ 学術雑誌論文
著者 Sabui, Subrata| Dutta, Sanjucta| Debnath, Anusuya| Ghosh, Avishek| Hamabata, T.| Rajendran, K.| Ramamurthy, T.| Nataro, James P.| Sur, Dipika| Levine, Myron M.| Chatterjee, Nabendu Sekhar|
発行日 2012-04
出版物タイトル Journal of Clinical Microbiology
50巻
4号
資料タイプ 学術雑誌論文
著者 Ghosh-Banerjee, J| Senoh, M| Takahashi, T| Hamabata, T| Barman, S| Koley, H| Mukhopadhyay, A. K| Ramamurthy, T| Chatterjee, S| Asakura, M| Yamasaki, S| Nair, G. B| Takeda, Y|
発行日 2010-09
出版物タイトル Journal of Clinical Microbiology
48巻
11号
資料タイプ 学術雑誌論文
著者 Taguchi, Fumiko| Ogawa, Yujiro| Takeuchi, Kasumi| Suzuki, Tomoko| Toyoda, Kazuhiro| Shiraishi, Tomonori| Ichinose, Yuki|
発行日 2006-12
出版物タイトル Journal of Bacteriology
188巻
24号
資料タイプ 学術雑誌論文
著者 Takeuchi, Kasumi| Ono, Hiroshi| Yoshida, Mitsuru| Ishii, Tadashi| Katoh, Etsuko| Taguchi, Fumiko| Miki, Ryuji| Murata, Katsuyoshi| Kaku, Hanae| Ichinose, Yuki|
発行日 2007-10
出版物タイトル Journal of Bacteriology
189巻
19号
資料タイプ 学術雑誌論文