start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=4 article-no= start-page=273 end-page=278 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220720 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Acute sensorineural hearing loss after using a privately imported PDE-5 inhibitor : A case report kn-title=個人輸入した PDE-5 阻害薬の内服後に生じた急性感音難聴の 1 例 en-subtitle= kn-subtitle= en-abstract=We herein report a case of acute sensory deafness that occurred immediately after taking a privately imported phosphodiesterase-5 inhibitor. A man in his 40s developed sensorineural hearing loss after using vardenafil purchased over the Internet. He received systemic prednisolone and discontinued vardenafil, which generally improved his hearing. Although it has been pointed out that phosphodiesterase-5 inhibitors are associated with deafness, this fact is not well known in Japan. It is easy to import phosphodiesterase-5 inhibitor for personal use via the Internet. However, many counterfeit drugs of phosphodiesterase-5 inhibitor are distributed online, causing health hazards. We should always be alert for any medications that need to be discontinued. kn-abstract=個人輸入した PDE-5 阻害薬内服後に急性感音難聴を生じた症例を経験したため報告する。症例は 40 代、男性。インターネット経由で購入したバルデナフィルを使用後に、感音難聴を生じた。プレドニゾロンの全身投与を行い、バルデナフィルを中止したところ、聴力はおおむね改善した。PDE-5 阻害薬は難聴との関連が指摘されているが、わが国では十分に周知されていない。PDE-5 阻害薬はインターネットで簡単に個人輸入できる一方で、偽造薬も数多く出回っており、健康被害も生じている。また、個人輸入薬は処方薬に比して服薬歴の把握が難しい場合があり、薬剤性難聴を疑う場合は詳細な問診を心掛ける必要がある。 en-copyright= kn-copyright= en-aut-name=KARIYAAkifumi en-aut-sei=KARIYA en-aut-mei=Akifumi kn-aut-name=假谷彰文 kn-aut-sei=假谷 kn-aut-mei=彰文 aut-affil-num=1 ORCID= en-aut-name=ISHIHARAHisashi en-aut-sei=ISHIHARA en-aut-mei=Hisashi kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=2 ORCID= en-aut-name=AKISADANaoki en-aut-sei=AKISADA en-aut-mei=Naoki kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=HAMADAKoji en-aut-sei=HAMADA en-aut-mei=Koji kn-aut-name=濱田浩司 kn-aut-sei=濱田 kn-aut-mei=浩司 aut-affil-num=4 ORCID= en-aut-name=FUJISayaka en-aut-sei=FUJI en-aut-mei=Sayaka kn-aut-name=藤さやか kn-aut-sei=藤 kn-aut-mei=さやか aut-affil-num=5 ORCID= en-aut-name=AKAGISeiko en-aut-sei=AKAGI en-aut-mei=Seiko kn-aut-name=赤木成子 kn-aut-sei=赤木 kn-aut-mei=成子 aut-affil-num=6 ORCID= en-aut-name=TAKEUCHIAyako en-aut-sei=TAKEUCHI en-aut-mei=Ayako kn-aut-name=竹内彩子 kn-aut-sei=竹内 kn-aut-mei=彩子 aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=2 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=3 en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科耳鼻咽喉・頭頸部外科学 affil-num=4 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=5 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=6 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=7 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 en-keyword=急性感音難聴 kn-keyword=急性感音難聴 en-keyword=薬剤性難聴 kn-keyword=薬剤性難聴 en-keyword=PDE-5 阻害薬 kn-keyword=PDE-5 阻害薬 en-keyword=バルデナフィル kn-keyword=バルデナフィル en-keyword=個人輸入薬 kn-keyword=個人輸入薬 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=6 article-no= start-page=402 end-page=406 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Idiopathic first bite syndrome improved by Rikkosan : A case report kn-title=立効散が有効であった特発性ファーストバイト症候群の1例 en-subtitle= kn-subtitle= en-abstract=First bite syndrome (FBS) is characterized by severe paroxysmal pain in the parotid region at the first bite of a meal, which gradually decreases as mastication continues. When FBS occurs with no history of head and neck surgery and no evidence of a tumor, it is classified as idiopathic. The effectiveness of Rikkosan has been reported by several studies, and we also experienced a case in which idiopathic FBS improved with Rikkosan. There is no established treatment method for idiopathic FBS. Rikkosan, which is associated with few adverse events, should be considered as a first-line treatment, along with diet therapy. kn-abstract=ファーストバイト症候群（first bite syndrome：以下、FBS）は、食事開始時に耳下腺部痛を生じ数回の咀嚼により徐々に軽快することを特徴とする。手術既往や腫瘍性疾患がない FBS は特発性 FBS と分類される。特発性 FBS に対する治療法として少数ではあるが立効散の内服が報告されており、本症例でも立効散が奏功した。特発性 FBS の治療法は未確立であり、有害事象の少ない立効散は食事療法と並んでまず考慮すべき治療法であると考える。 en-copyright= kn-copyright= en-aut-name=SatoAsuka en-aut-sei=Sato en-aut-mei=Asuka kn-aut-name=佐藤明日香 kn-aut-sei=佐藤 kn-aut-mei=明日香 aut-affil-num=1 ORCID= en-aut-name=IshiharaHisashi en-aut-sei=Ishihara en-aut-mei=Hisashi kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=2 ORCID= en-aut-name=KariyaAkifumi en-aut-sei=Kariya en-aut-mei=Akifumi kn-aut-name=假谷彰文 kn-aut-sei=假谷 kn-aut-mei=彰文 aut-affil-num=3 ORCID= en-aut-name=AkisadaNaoki en-aut-sei=Akisada en-aut-mei=Naoki kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=FujiSayaka en-aut-sei=Fuji en-aut-mei=Sayaka kn-aut-name=藤さやか kn-aut-sei=藤 kn-aut-mei=さやか aut-affil-num=5 ORCID= en-aut-name=AkagiSeiko en-aut-sei=Akagi en-aut-mei=Seiko kn-aut-name=赤木成子 kn-aut-sei=赤木 kn-aut-mei=成子 aut-affil-num=6 ORCID= en-aut-name=TakeuchiAyako en-aut-sei=Takeuchi en-aut-mei=Ayako kn-aut-name=竹内彩子 kn-aut-sei=竹内 kn-aut-mei=彩子 aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=2 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=3 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=4 en-affil=Department of Otolaryngology, Head and Neck Surgery, Okayama University Postgraduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil=岡山大学大学院医歯薬学総合研究科耳鼻咽喉・頭頸部外科 affil-num=5 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=6 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=7 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 en-keyword=First bite syndrome, kn-keyword=First bite syndrome, en-keyword=立効散 kn-keyword=立効散 en-keyword=耳下腺部痛 kn-keyword=耳下腺部痛 en-keyword=顔面痛 kn-keyword=顔面痛 en-keyword=糖尿病性神経障害 kn-keyword=糖尿病性神経障害 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=2 article-no= start-page=112 end-page=117 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lemierre's syndrome following peritonsillar abscess : A case report kn-title=扁桃周囲膿瘍からレミエール症候群を来した 1 例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Lemierre's syndrome is a disorder in which bacterial infection of the head and neck region leads to thrombosis of the internal jugular vein ; left untreated, this condition can also result in metastatic infections in the lungs and joints as well as bacterial sepsis. An early diagnosis and treatment are important for preventing these pathologic outcomes. We herein report the case of a 30-year-old male with internal jugular vein thrombosis secondary to a peritonsillar abscess accompanied by septic emboli in the lung. The criteria proposed by Yamamoto and Sugiura et al. were used to facilitate a rapid diagnosis of his condition prior to obtaining results from blood cultures. While Lemierre's syndrome is a fairly uncommon diagnosis at this time, its incidence has been increasing given the current pressure to limit the use of antibiotics. Antimicrobial use is currently restricted in Japan due to efforts designed to curb the emergence of drug resistance; as such, we may begin to see more cases of this disease. Although rare, some patients with infection of the head and neck region do develop Lemierre's syndrome ; as such, frequent follow-up of all cases of acute pharyngitis is necessary, notably for those patients not treated with antimicrobial agents. en-copyright= kn-copyright= en-aut-name=KAJIHARASohei en-aut-sei=KAJIHARA en-aut-mei=Sohei kn-aut-name=梶原壮平 kn-aut-sei=梶原 kn-aut-mei=壮平 aut-affil-num=1 ORCID= en-aut-name=ISHIHARAHisashi en-aut-sei=ISHIHARA en-aut-mei=Hisashi kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=2 ORCID= en-aut-name=KARIYAAkifumi en-aut-sei=KARIYA en-aut-mei=Akifumi kn-aut-name=假谷彰文 kn-aut-sei=假谷 kn-aut-mei=彰文 aut-affil-num=3 ORCID= en-aut-name=AKISADANaoki en-aut-sei=AKISADA en-aut-mei=Naoki kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=SHIGEHARAAkiko en-aut-sei=SHIGEHARA en-aut-mei=Akiko kn-aut-name=茂原暁子 kn-aut-sei=茂原 kn-aut-mei=暁子 aut-affil-num=5 ORCID= en-aut-name=SATOAki en-aut-sei=SATO en-aut-mei=Aki kn-aut-name=佐藤晶 kn-aut-sei=佐藤 kn-aut-mei=晶 aut-affil-num=6 ORCID= en-aut-name=HAMADAKoji en-aut-sei=HAMADA en-aut-mei=Koji kn-aut-name=M田浩司 kn-aut-sei=M田 kn-aut-mei=浩司 aut-affil-num=7 ORCID= en-aut-name=AKAGIYusuke en-aut-sei=AKAGI en-aut-mei=Yusuke kn-aut-name=赤木祐介 kn-aut-sei=赤木 kn-aut-mei=祐介 aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Otorhinolaryngology, Okayama Medical Center kn-affil=国立病院機構岡山医療センター耳鼻咽喉科 affil-num=2 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=3 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=4 en-affil=Department of Head and Neck Surgery, Shikoku Cancer Center kn-affil=国立病院機構四国がんセンター頭頸科 affil-num=5 en-affil=Department of Otorhinolaryngology, Okayama Medical Center kn-affil=国立病院機構岡山医療センター耳鼻咽喉科 affil-num=6 en-affil=Department of Otorhinolaryngology, Okayama Medical Center kn-affil=国立病院機構岡山医療センター耳鼻咽喉科 affil-num=7 en-affil=Department of Otorhinolaryngology, Okayama Medical Center kn-affil=国立病院機構岡山医療センター耳鼻咽喉科 affil-num=8 en-affil=Department of Otorhinolaryngology, Okayama Medical Center kn-affil=国立病院機構岡山医療センター耳鼻咽喉科 en-keyword= Lemierre's syndrome kn-keyword= Lemierre's syndrome en-keyword=Fusobacterium necrophorum kn-keyword=Fusobacterium necrophorum en-keyword=Antimicrobial Resistance kn-keyword=Antimicrobial Resistance en-keyword=扁桃周囲膿瘍 kn-keyword=扁桃周囲膿瘍 en-keyword=耳鼻咽喉科救急 kn-keyword=耳鼻咽喉科救急 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=26 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=HIV infection diagnosed from delayed wound healing after tonsillectomy : A case report kn-title=口蓋扁桃摘出術後の創傷治癒遅延を契機に判明した HIV 感染症の1例 en-subtitle= kn-subtitle= en-abstract=HIV (human immunodeficiency virus) lowers the immune capacity of the host and causes AIDS (acquired immunodeficiency syndrome) when it progresses. HIV infection is known to have a variety of symptoms, and it is often diagnosed based on the occurrence of various otorhinolaryngological conditions. We experienced a case in which an HIV infection was diagnosed based on delayed wound healing after tonsillectomy. The early initiation of treatment for HIV infection is known to be effective for controlling progression, so it is important to detect HIV infection as early as possible. Preoperative HIV screening tests may lead to the early detection of HIV, and such tests are also important to prevent delayed wound healing. In Japan, it remains a problem that preoperative HIV screening is sometimes not allowed under by the Japanese National health insurance system. kn-abstract=HIV（human immunodeficiency virus）は感染すると宿主の免疫能を低下させ、進行すると AIDS（acquired immunodeficiency syndrome）を引き起こす。HIV 感染症は多彩な症状を呈することが知られており、創傷治癒遅延もその一つである。今回われわれは口蓋扁桃摘出術後の創傷治癒遅延から HIV 感染症と判明した症例を経験した。HIV 感染症は早期の治療開始が予後改善のために推奨されており、早期発見が重要である。手術前 HIV スクリーニング検査は創傷治癒遅延を防ぐ意味でも重要と考えられるが、現行の保険制度上は認められない場合があり、保険適用範囲の拡大が望まれる。 en-copyright= kn-copyright= en-aut-name=KariyaAkifumi en-aut-sei=Kariya en-aut-mei=Akifumi kn-aut-name=假谷彰文 kn-aut-sei=假谷 kn-aut-mei=彰文 aut-affil-num=1 ORCID= en-aut-name=IshiharaHisashi en-aut-sei=Ishihara en-aut-mei=Hisashi kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=2 ORCID= en-aut-name=AkisadaNaoki en-aut-sei=Akisada en-aut-mei=Naoki kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=FujisawaIku en-aut-sei=Fujisawa en-aut-mei=Iku kn-aut-name=藤澤郁 kn-aut-sei=藤澤 kn-aut-mei=郁 aut-affil-num=4 ORCID= en-aut-name=FujiSayaka en-aut-sei=Fuji en-aut-mei=Sayaka kn-aut-name=藤さやか kn-aut-sei=藤 kn-aut-mei=さやか aut-affil-num=5 ORCID= en-aut-name=AkagiSeiko en-aut-sei=Akagi en-aut-mei=Seiko kn-aut-name=赤木成子 kn-aut-sei=赤木 kn-aut-mei=成子 aut-affil-num=6 ORCID= en-aut-name=TakeuchiAyako en-aut-sei=Takeuchi en-aut-mei=Ayako kn-aut-name=竹内彩子 kn-aut-sei=竹内 kn-aut-mei=彩子 aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=2 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=3 en-affil=Department of Head and Neck Surgery, Shikoku Cancer Center kn-affil=国立病院機構四国がんセンター頭頸科 affil-num=4 en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科耳鼻咽喉・頭頸部外科学 affil-num=5 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=6 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=7 en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital kn-affil=岡山赤十字病院耳鼻咽喉科 en-keyword=HIV（human immunodeficiency virus） kn-keyword=HIV（human immunodeficiency virus） en-keyword=創傷治癒遅延 kn-keyword=創傷治癒遅延 en-keyword=口蓋扁桃摘出術 kn-keyword=口蓋扁桃摘出術 en-keyword=手術合併症 kn-keyword=手術合併症 en-keyword=性感染症 kn-keyword=性感染症 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=3 article-no= start-page=87 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=2019 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of acquired haemophilia A with epistaxis kn-title=鼻出血を契機に判明した後天性血友病 A の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=後天性血友病 A とは、凝固第[因子に対する自己抗体が出現し出血症状を呈する疾患である。われわれは鼻出血を契機に発見された後天性血友病 A の 1 例を経験した。症例は 73 歳、男性。鼻出血を繰り返し、当科を受診した。出血点を認め焼灼するも再出血した。APTT 延長を認めたため当院血液内科に紹介し、後天性血友病と診断され現在治療中であり、治療開始後は再出血なく経過している。後天性血友病の初発症状は、皮下や筋肉内の出血が多く、鼻出血を契機に発見された症例はまれである。比較的まれな疾患ではあるが、診断が遅れれば、頭蓋内出血や腹腔内出血といった致死的な出血を来す可能性がある。早期診断・治療が重要であり、耳鼻咽喉科医も知識を有しておくべき疾患である。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=秋定直樹 kn-aut-sei=秋定 kn-aut-mei=直樹 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石原久司 kn-aut-sei=石原 kn-aut-mei=久司 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=竹内彩子 kn-aut-sei=竹内 kn-aut-mei=彩子 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤澤郁 kn-aut-sei=藤澤 kn-aut-mei=郁 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=赤木成子 kn-aut-sei=赤木 kn-aut-mei=成子 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=2 en-affil= kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=3 en-affil= kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=4 en-affil= kn-affil=岡山赤十字病院耳鼻咽喉科 affil-num=5 en-affil= kn-affil=岡山赤十字病院耳鼻咽喉科 en-keyword=鼻出血 kn-keyword=鼻出血 en-keyword=後天性血友病 kn-keyword=後天性血友病 en-keyword=凝固第[因子 kn-keyword=凝固第[因子 en-keyword=第[因子インヒビター kn-keyword=第[因子インヒビター en-keyword=出血性疾患 kn-keyword=出血性疾患 END