start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=1 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for 999 patients with respiratory disease admitted at Misasa Medical Branch for last 7 years kn-title=呼吸器疾患に対する温泉療法.　最近7年間(1993年-1999年)の入院症例999例を対象に en-subtitle= kn-subtitle= en-abstract=The patients with asthma or COPD who were admitted at our hospital for last 7 years (1993-1999) were examined in relation to patient age and areas where patients came. 1. Of 829 patients with obstructive ventilatory dysfunction, 636 patients (76.7% ) had asthma. The frequency of asthma in all patients with obstructive ventilatory dysfunction was the highest (84.5% ) in 1993 and showed a tendency to decrease to 65.5% in 1999. In contrast, the frequency ofpulmonary emphysema tended to increase from 5.6% in 1993 to 25.6% in 1999. 2. The number of patients with asthma or COPD from distant areas (outside Tottori prefecture) was larger (433 patients; 52.2% ) than the number of those inside Tottori prefecture (396 patients) for 7 years. The number of patients from Okayama, Osaka, Hyogo, Hiroshima, Yamaguchi, Ehime, Tokyo, and Kanagawa was. larger than the number from other distant areas. 3 . Regarding the distribution of age of these patients, the number of patients over the age of 50 in all subjects was larger in patients from distant areas (96.7% ) than in those inside Tottori prefecture (80.9% ) kn-abstract=1993年1月より1999年12月までの7年間に当院へ入院した呼吸器疾患999例のうち閉塞性換気障害を示す829例(気管支慌息BA+COPD)を対象に,年齢,地域分布などの経年変化について検討を加えた｡ 1.最近7年間に当院へ入院した閉塞性呼吸器疾患患者829例のうち, 気管支喘息は636例(76.7% )であった｡閉塞性呼吸器疾患のなかで気管支喘息の占める割合の経年変化では,1996年度が最も高く(84.5% )その後徐々に低下する傾向か見られ1999年度では65.5% であった｡一方′肺気腫は近年増加の傾向を示し,19993年度では5.6% であったが.1999年度では25.6% であった｡　 2.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,この7年間の鳥取県外(遠隔地)からの入院患者は829例中433例(52.2% )であった｡また,岡山,大阪,兵庫,広島,山口,愛媛,東京,神奈川などからの入院症例か多い傾向が見られた｡　 3.年齢別検討では,いずれの地域においても,高齢者の入院症例が多く,鳥取県内,県外を問わず,70才以上の症例の頻度が明らかに高い傾向か見られた.そして,50才以上の症例の全症例に対する頻度は,鳥取県内では80.9% ,県外では96.7% であり,県内ではその多くが,また県外ではそのほとんどが50才以上の症例であった｡ en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=気管支喘息 (asthma) kn-keyword=気管支喘息 (asthma) en-keyword=肺気腫 (pulmonary emphysema) kn-keyword=肺気腫 (pulmonary emphysema) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) en-keyword=高齢患者 (aged patients) kn-keyword=高齢患者 (aged patients) en-keyword=遠隔地 (distant area) kn-keyword=遠隔地 (distant area) END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=10 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=高齢者気管支喘息における気道過敏性と温泉療法 kn-title=Spa therapy and bronchial hyperresponsiveness in elderly patients with asthma en-subtitle= kn-subtitle= en-abstract=1.温泉療法では,年齢が高くなるほどその有効率も高くなると言う傾向が見られ､49才以下の症例では73.3% ,50-59才の症例では81.8% , 60-69才の症例では86.4% ,70才以上では90.6% であり,全症例の平均有効率は73.3% であった｡　 2.気道過敏性は,年齢が高くなるほど低下する傾向が見られ,60-69才および70才以上の症例の気道過敏性は,49才以下の症例と比べ有 意に低い値を示した(P < 0.001)。　 3.温泉療法の臨床効果は,気道過敏性が強くなるにつれて低下する傾向が見られた｡また,温泉療法の著効例や有効例では,治療により 気道過敏性が低下してくるが､やや有効例や無効例では,気道過敏性はほとんど変化しないことが示された｡ kn-abstract=Clinical effects of spa therapy were examined in 150 patients with asthma in relation tobronchial hyperresponsiveness and patient age. 1. The efficacy rate of spa therapy was larger as the patient age was higher: the rate was 73.3% in patients under age 49, 81.8% in those between the ages of 50 and 59, 86.4% in those between the ages of 60 and 69, and 90.6% in those over age 70. The mean of efficacy rates was 83.3% in all subjects. 2. The bronchial hyperresponsiveness (BH) was lower as patient age was higher: the BH in patients between the ages of 60 and 69 and in those over age 70 was significantly lower compared to the BH in those under age 49 (p < O.OOl). 3. Clinical effects of spa therapy tended to be lower in patients with increased bronchial hyperresponsiveness. The bronchial hyperresponsiveness showed a tendency to decrease after spa therapy in whom the therapy was effective, however, the BH did not change in patients with slight or no efficacy during spa therapy. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=spa therapy kn-keyword=spa therapy en-keyword=asthma kn-keyword=asthma en-keyword=bronchial hyperresponsiveness kn-keyword=bronchial hyperresponsiveness en-keyword=patient age kn-keyword=patient age END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=19 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=胸部高分解能CT（HRCT）による肺野low attenuation area（LAA）の定量的評価　―気管支喘息および肺気腫症例の比較検討― kn-title=Quantitative evaluation by high resolution computed tomography (HRCT) of patients with asthma and emphysema en-subtitle= kn-subtitle= en-abstract=【目的】肺野low attenuation area（LAA）は、慢性閉塞性肺疾患（COPD）における肺気腫の存在ならびに程度を反映することが知られている。そこで喘息患者におけるLAAの意義を明らかにすることを目的として、COPD患者、コントロールとの比較検討を行った。　 【対象と方法】喘息症例24例、COPD症例23例、コントロール15例を対象として、上・中・下肺野の3スライスで深吸気、深呼気時において胸部高分解能CT（HRCT）を施行し3群間で比較検討を行った。CTパラメーターとしては、平均m値、肺野面積に対する－950HU以下のLAAの割合（% LAA）を採用した。　 【結果】1．3スライスの平均CT値は、吸気および呼気とも3群間での有意の差が認められた。2．3スライスの% LAAは、吸気では3群間での有意の差が認められたが、呼気では喘息とコントロール間での有意の差は認められなかった。3．COPD症例では、吸気、呼気ともに平均CT値は他の2群より有意に低値を示し、% LAAは他の2群よりより有意に高値を示した。4．3群間の平均CT値と% LAAの相違は下肺野のスライスで最も顕著であった。　 【考案】平均CT値および% LAAは、喘息、COPD、コントロールにおいて有意に異なっており、喘息およぴCOPDの病態を反映する可能性が示唆された。 kn-abstract=Background: Assessment of low attenuation areas and lung densitometry on high resolution computed tomography (HRCT) have been reported in studies of patients with chronic obstructive pulmonary disease. Objective : The purpose of this study was to examine if HRCT could separate asthmatic patients from normal control subjects and patients with emphysema. Methods : Subjects were divided into three groups : 24 patients with bronchial asthma, 23 patients with pulmonary emphysema and 15 normal controls. HRCT scans of the lung were performed at three different levels at both end inspiration and expiration in all patients and control subjects. Results : The mean CT number of three slices was significantly lower in asthmatic subjects compared with normal individuals at both end inspiration (p < 0.05) and expiration (p < 0.01). The relative area of the lung with an attenuation value lower than -950 HU (% LAA) for three slices was significantly higher in asthmatic subjects than in normal individuals at end inspiration (p < 0.05), but there was no significant difference at end expiration. The mean CT number and % LAA obtained from studies that were performed at three cm above the top of the diaphragm provided the best separation among three anatomic levels. In comparison between asthmatic and emphysema patients, both parameters were significantly different in asthmatic subjects than in those with emphysema at both end inspiration and expiration on each scan and in the total scans (p < 0.001). Conclusions : HRCT is a useful method to separate asthmatic subjects from patients with emphysema and normal subjects. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=5 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=6 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=7 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=HRCT kn-keyword=HRCT en-keyword=asthma kn-keyword=asthma en-keyword=emphysema kn-keyword=emphysema END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=29 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者における肺機能とHRCT上のlow attenuation areaに対する喫煙の影響 kn-title=Correlation between pulmonary function and low attenuation area (LAA) on HRCT III patients with asthma in relation to smoking en-subtitle= kn-subtitle= en-abstract=気管支喘息49例を対象に､肺機能およびHigh resolution computed tomography(HRCT)上のLow attenuation are (LAA) <-950HUで示される肺気腫様変化に及ぼす喫煙の影響について検討した｡　 1.気管支喘息患者のうち､非喫煙例では% 残気量(% RV)は多くの症例(65.6% )で129% 以下であったが､一方喫煙症例では130% から189% を示す症例が最も多く見られた(60.0% )｡非喫煙例および喫煙例いずれにおいても､ 2.% RVと% LAA､% RVとCT number 間に有意の相関が見られた: % RVが上昇するにつれて､% LAA値は増加し､CT numberは低下する傾向が見られた｡　 3.喫煙例では､% RVが130-189% あるいは190% 以上の症例で､% DLco値 が明かに低値を示す症例が見られたが､非喫煙症例では% RVが高い値を示しても% DLcoの低下はみられなかった｡　 4.喫煙例､非喫煙例いずれにおいても､% FEV1.0倍と% RV値の問には有意の相関が見られ､% RV値が上昇するにつれて､% FEV1.0値は低下する傾向が見られた｡　 5.% FVCと% RVの問には相関は見られなかった｡以上の結果より､喫煙は気管支喘息患者のHRCT上の% LAAおよび% DLcoに影響を与えることが示唆された｡ kn-abstract=The influence of smoking on pulmonary function and emphysematous changes of the lung (percentage of attenuation area < -950 HU (% LAA) on high resolution computed tomography (HRCT) was examined in 49 patients with bronchial asthma. 1. In patients with asthma, the % residual volume (RV) in many nonsmokers was less than 129%, in contrast, the % RV in many smokers was between 130% and 189% , which was higher than that in nonsmokers. 2. Significant correlations between % RV and 96LAA value, and between % RV and CT number were observed both in nonsmokers and smokers with asthma, in which as % RV more increased, % LAA value was larger, and CT number was lower. 3. % DLco value was lower in smoking patients with asthma, whose % RV was between 130% and 189% and larger than 190% , however, the % DLco value did not change in nonsmoking patients despite of higher valure in % RV. 4. A significant correlation was also observed between % FEV1.0 value and % RV both in smoking and nonsmoking patients with asthma; as % RV value more increased, % FEV1.0 value was lower. 5. Any correlation between % FVC value and % RV was not observed. These results suggest that smoking affects the % LAA of the lung on HRCT and % DLco in patients with asthma. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=5 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=6 ORCID= en-aut-name=TakadaShingo en-aut-sei=Takada en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=7 ORCID= en-aut-name=YokoiTadashi en-aut-sei=Yokoi en-aut-mei=Tadashi kn-aut-name=横井正 kn-aut-sei=横井 kn-aut-mei=正 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=asthma kn-keyword=asthma en-keyword=smoking kn-keyword=smoking en-keyword=% LAA of the lungs kn-keyword=% LAA of the lungs en-keyword=FEV1.0 kn-keyword=FEV1.0 en-keyword=DLco kn-keyword=DLco END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=36 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息症例における末梢血白血球のロイコトリエンC4産生能とロイコトリエン受容体括抗薬プランルカストの効果に関する検討 kn-title=Correlation between efficacy of Pranlukast and LTC4 generation by peripheral leukocytes en-subtitle= kn-subtitle= en-abstract=軽症気管支喘息18例にロイコトリエン受容体桔抗薬プランルカストを4週間投与し，その効果と末梢血白血球からのLTC4，LTB4産生能の関係を検討した．プランルカストの効果は臨床症状，起床時ピークフロー値，肺機能の変化によって判定し，効果群，非効果群の2群に分類した．18例中12例（67％）の症例がプランルカスト投与により，臨床症状の軽減，ピークフロー値の増加，肺機能の改善が認められた．効果群におけるプランルカスト投与前のLTC4値は，非効果群のLTC4値に比較して有意に高値であった．4週間の投与後には 効果群ではLTC4値は減少し，非効果群では増加した．両群のLTB4値はプランルカスト投与前で有意な差は認められず，投与後には両群で減少した．投与前の好酸球分画は，効果群において非効果群に比べ高値であったが，有意な差は認められなかった．4週間の投与後，効果群においては好酸球は減少し，非効果群においては増加した．以上の結果より，プランルカストは末梢血白血球のLTC4産生能が高い症例において効果的であり，好酸球集積を抑制する作用を有すると考えられる． kn-abstract=The correlation between the efficacy of 4-weeks administration with pranlukast, leukotriene receptor antagonist, and LTs generation by peripheral leukocytes were evaluated in 18 patients with mild-persistent asthma. The efficacy of pranlukast administration was assessed by symptom, morning PEF and pulmonary function. Pranlukast were effective in 12/18(67%) patients. In those patients, LTC4 generation before pranlukast administration was significantly high, compared with that in pranlukast-ineffective patients. LTC4 generation decreased after 4-weeks administration with pranlukast in effective patients. In ineffective patients, however, LTC4 generation increased after 4-weeks administration. LTB4 had shown no significant difference between effective and ineffective patients before administration, and LTB4 decreased after 4-weeks in both groups. Proport ion of peripheral eosinophi Is in effective patients were higher than that in ineffective patients, however not significant. After 4-weeks, proportion of eosinophi Is was decreased in effective patients and increased in ineffective patients. These findings suggest that pranlukast is effective for patients with high LTC4 generation and has the effect to suppress the accumulation of eosinophils in such patients. en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=TakadaShingo en-aut-sei=Takada en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=2 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=3 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=6 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=pranlukast kn-keyword=pranlukast en-keyword=leukotriene receptor antagonist kn-keyword=leukotriene receptor antagonist en-keyword=LTC4 kn-keyword=LTC4 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=42 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=寒冷負荷の末梢循環に及ぼす影響 kn-title=Effect of partial cold-loading on peripheral circulation en-subtitle= kn-subtitle= en-abstract=局所寒冷負荷の全身の末梢循環に及ぼす影響について検討する目的で，下肢の20℃冷水負荷時における上肢末梢循環の変化をレーザードプラー血流計を用いて数量的に測定し検討を行なった。症例は，下肢に冷え症，しびれ感を有した25歳から86歳までの24症例（平均年齢64.3歳）であった。下肢，上肢の末梢循環を20℃冷水負荷時に，末梢血流量，血液量，血流速度について観察した。上肢の末梢血流量は20℃室内安静時平均5.00mβ/min/100g tissue，血液量は287，血流速度は0.516であった。下肢は血流量2.23，血液量は149，血流速度は0.574であった。上肢の血流量，血液量ともに下肢より多いことが示された。しかし同一症例における上肢と下肢との間の血流量，血液量，血流速度に相関関係は認めなかった。下肢の20℃ 冷水負荷中の上肢の血流量は平均3.69で有意に低下（26.2％）した。下肢はその間1．51で有意に低下（32.3％）した。上肢の血液量は平均241で有意に低下（16．0％）した。下肢はその間113で有 意に低下（24.2％）した。上肢の血流速度は平均0.501で不変であった。下肢はその間0．642で有意に増加（11.8％）した。冷水負荷直後よりそれぞれ負荷前に復帰する傾向を示した。負荷後20分では上肢の血流量は平均5．74で負荷前値に比べて増加（14.8％）傾向を示した。下肢は1.87で負荷前値に比べて低値（83.9％）に留まる傾向にあった。下肢の冷水負荷は上肢の末梢循環にも影響を及ぼすことが数量的に示された。局所の寒冷負荷による体温の低下を防ぐために反射的に全身の皮膚の末梢循環量を低下させていることが示された。 kn-abstract=The purpose of this study is the effect of partial cold-loading on whole body peripheral circulation. The body surface peripheral circulation in 24 cases (25 years old to 86 years old, the average was 64.3 years) who were suffering coldness, numbness or pain in their feet was examined using Laser-Doppler blood flowmetry. The peripheral circulation at the base of the 2nd toe of the right foot was estimated after the foot was submerged and cooled for 5 min in a water bath at 20°C (i. e. cold-loading). At the same time, the distant body surface peripheral circulation was estimated at the base of the 2nd finger of the right hand. Simultaneous observations were made of blood flow, blood mass and blood velocity. The peripheral blood flow of the upper limbs at a room temperature of 20°C (pre-loading) was 5.00 ml/min 100 9 tissue on average. The average blood rnass was 287 and the average blood velocity was 0.516. On the other hand, the average peripheral blood flow of the lower limbs was 2.23, the average blood mass was 149 and the average blood velocity was 0.574. This result shows that the blood flow and blood mass of the upper limbs were more than in the lower limbs. The average blood flow at the upper limbs decreased to 3.69 from 5.00 (or at 26.2% ) when the lower limbs were submerged and cooled for 5 min in a water bath at 20°C (i. e. cold-loading). On the other hand, blood flow of the lower limb was 1.51 m l under a condition of cold-loading, and decreased 32.3% from 2.23. Blood mass of the upper limb was 241 on average and decreased 16.0% from 287. Blood mass of the lower limb was 113 on average and decreased 24.2% from 149. There was no difference between blood velocity of the upper limb under the conditions of room temperature at 20°C (0.516) and cold-loading (0.501). However, blood velocity of the lower limb increased to 0.642 from 0.574. After the end of cold loading, there was some tendency for blood flow, blood rnass and blood velocity to return to the amount at pre-loading. Twenty minutes after the end of cold-loading, blood flow increased to 5.74 (14.8% ) compared with pre-loading (5.00). However, blood flow of the lower limb remained at only 83.9% (1.87) of the amount at pre-loading (2.23). These results show that partial cold-loading of the lower limb had a quantitative effect on the distant peripheral circulation. The speculated mechanism of this phenomenon is that it to protects against loosing body heat from the body surface under the conditions of local cold-loading. Our body has defense mechanisms to decrease whole body peripheral circulation to protect against loosing body heat. en-copyright= kn-copyright= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=5 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=6 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=7 ORCID= en-aut-name=YokoiTadashi en-aut-sei=Yokoi en-aut-mei=Tadashi kn-aut-name=横井正 kn-aut-sei=横井 kn-aut-mei=正 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=医学部臨床検査医学 affil-num=11 en-affil= kn-affil=医学部第一内科 en-keyword=Laser-Doppler blood flowmetry (レーザードプラー血流計) kn-keyword=Laser-Doppler blood flowmetry (レーザードプラー血流計) en-keyword=cold loading (冷水負荷) kn-keyword=cold loading (冷水負荷) en-keyword=peripheral circulation (末梢循環) kn-keyword=peripheral circulation (末梢循環) en-keyword=blood flow (血流量) kn-keyword=blood flow (血流量) en-keyword=blood velocity (血流速度) kn-keyword=blood velocity (血流速度) END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=50 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=脂肪の変化と関連した気管支喘息に対するn－3系脂肪酸食の効果 ― n－6系脂肪酸との比較 kn-title=Effects of dietary supplementation with n－3 fatty acidson bronchial asthma associated with changes in lipids．－Comparison with n－6 fatty acids－ en-subtitle= kn-subtitle= en-abstract=n－3系脂肪酸は喘息に有効であることが報告されている。今回、エゴマ油（n－3系脂肪酸）の喘息に対する効果を呼吸機能、イコトリエンC4（LTC4）産生能の観点から、コーン油（n－6系脂肪酸）のそれと比較した。28例の喘息患者を無作為に2群に分け、A群（15例） はエゴマ油食を、B群（13例）はコーン油食をそれぞれ4週間摂取した。白血球LTC4産生能、呼吸機能、血清脂質を2群間で比較した。白血球LTC4産生能はエゴマ抽食を摂取したA群で2週後（P < 0．05）、4過後（P < 0．01）に有意に低下した。食事摂取4過後に岳群間でLTC4産生能に有意差が認められた（P < 0．05）。エゴマ油食を4過摂取したA群ではピークフロー（P < 0．05）、肺活量（P < 0.01）、1秒量（P < 0．05）が食事摂取前に比し、有意に増加した。またA群ではエゴマ坤食摂取4週後に血清総コレステロール値、LDL－コレステロール値、リン脂質の有意な低下がみられた。こ れらの結果より、エゴマ油食は白血球LTC4産生能を抑制することにより、呼吸機能を改善し、血清脂質の変化と関連して、喘息の治療に有効であることが示唆された。 kn-abstract=N-3 fatty acids have been reported to be effective for asthma. In the present study, the effects of perilla seed oil (n-3 fatty acids) on asthma were compared with the effects of corn oil (n-6 fatty acids) in terms of pulmonary function, lipometabolism and the generation of leukotriene C4 (LTC4) by leucocytes. A total of 28 asthmatic patients were randomly divided into two groups : Group A patients (15 subjects) consumed perilla seed oil-rich supplementation, while Group B patients (13 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTC4 by leucocytes, respiratory function and the serum levels of lipids were compared between the two groups. The generation of LTC4 by leucocytes decreased significantly in Group A subjects following perilla seed oil-rich supplementation for 2(P < 0.05) and 4 weeks(P < 0.01). A significant difference in the generation of LTC4 was observed between the two groups after different dietary supplementations for 4 weeks (P < 0.05). Significantly increased values for PEF (P < 0.01), FVC (P < 0.05) and FEV1.0 (P < 0.05) were found in Group A subjects following perilla seed oil supplementation for 4 weeks, compared with the initial value prior to supplementation. A significant decrease in the serum level of total cholesterol, LDL-cholesterol and phospholipid was detected in Group A subjects following perilla seed oil supplementation for 4 weeks. The present results suggest that peril la seed oil-rich supplementation is effective in the treatment of asthma in terms of its ability to suppress LTC4 generat ion by leucocytes, and in inducing an improvement in pulmonary function associated with changes in the serum level of lipids. en-copyright= kn-copyright= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学第二内科 en-keyword=perilla seed oil (エゴマ抽) kn-keyword=perilla seed oil (エゴマ抽) en-keyword=a -1inolenic acid (α－リノレン酸) kn-keyword=a -1inolenic acid (α－リノレン酸) en-keyword=leukotriene C4 (ロイコトリエンC4) kn-keyword=leukotriene C4 (ロイコトリエンC4) en-keyword=respiratory function (呼吸機能) kn-keyword=respiratory function (呼吸機能) en-keyword=脂質代謝 kn-keyword=脂質代謝 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=59 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ステロイド依存性気管支喘息症例の病的骨折と皮質骨傷害の検討 kn-title=Glucocorticoid-induced cortical bone porosity in postmenopausal patients with asthma en-subtitle= kn-subtitle= en-abstract=【目的】骨強度には皮質骨の状態が主に関与するため，全身ステロイド療法に伴う病的骨折と皮質骨障害について検討した。【方法】閉経後女性気管支喘息患者82例で，ステロイド依存性群と非依 存群において，椎体骨折数，槙骨皮質骨骨密度，皮質骨容量，骨強度（SSI）をⅩ線側面像とpQCTを用いて検討した。 【結果】ステロイド依存群はステロイド非依存群に比べて，椎体圧迫骨折数は有意に多く，榛骨皮質骨骨密度，皮質骨容積比，骨強度は各々有意に低下していた。また，皮質骨骨密度と容積は一定の割合で減少していた。椎体圧迫骨折数は皮質骨骨密度，皮質骨容積比，骨強度の全てと高い相関を認めた。 【結論】ステロイド依存性気管支暗息症例においては，皮質骨の骨 密度と容量が同時に減少して骨強度が減少することによって，病的骨折が発症すると考えられた。 kn-abstract=In a previous study, we demonstrated that chronic administration of systemic glucocorticoids decreases cortical bone mineral density (BMD) and induces development of pathologic fractures in asthmatic patients. To investigate cortical bone porosity due to glucocorticoids, we studied cortical bone volume, BMD, bone strength, and fractures in patients with asthma in this report. A total of 82 postmenopausal asthmatic patients were enrolled in the study. Vertebral fractures were diagnosed via plain spinal radiograms. Peripheral quantitative computed tomography (pQCT) was used to measure cortical BMD, relative cortical volume, and Strength Strain Index (SSI). Multiple regression analysis, Student's t test, and other statistical analyses were performed. Patients with systemic glucocorticoids therapy had lower cortical BMD, relative cortical volume, SSI, and more number of vertebral fractures than patients without it. Lifetime cumulative dose of glucocorticoids was related to cortical BMD, relative cortical volume, SSI, and the number of vertebral fractures. The cortical volumedensity relationship appeared to remain constant regardless of systemic glucocorticoid administration. The number of vertebral fractures correlated highly with cortical BMD, relative cortical volume, and SSI at the radius. In conclusion, systemic glucocorticoid administration decreases cortical bone density, cortical bone volume, and bone strength. G lucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites. Given that both cortical bone density and volume provide bone strength, cortical bone porosity was seen to contribute to glucocorticoid - induced bone strength loss and fractures. en-copyright= kn-copyright= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=1 ORCID= en-aut-name=GotoBunrei en-aut-sei=Goto en-aut-mei=Bunrei kn-aut-name=後藤文禮 kn-aut-sei=後藤 kn-aut-mei=文禮 aut-affil-num=2 ORCID= en-aut-name=NakaiMutsuro en-aut-sei=Nakai en-aut-mei=Mutsuro kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=3 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=4 ORCID= en-aut-name=TakataSingo en-aut-sei=Takata en-aut-mei=Singo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=5 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=6 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=9 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=10 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=カルシウム研究所 affil-num=3 en-affil= kn-affil=岡山大学三朝分院放射線室 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学三朝分院放射線室 affil-num=11 en-affil= kn-affil=岡山大学第一内科 affil-num=12 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=glucocorticoid kn-keyword=glucocorticoid en-keyword=cortical bone kn-keyword=cortical bone en-keyword=pQCT kn-keyword=pQCT en-keyword=osteoporosis kn-keyword=osteoporosis END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=68 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of systemic lupus erythematosus (SLE) associated with disseminated intravascular coagulation (DIC) kn-title=播種性血管内凝固症候群（DIC）を合併した全身性エリテマトーデス（SLE）の1例 en-subtitle= kn-subtitle= en-abstract=A case of disseminated intravascular coagulation (DIC) in a patient with systemic lupus erythematosus (SLE) was described. A 73-year-old female was diagnosed as having rheumatoid arthritis when she was 64 years old. In Jan, 1999, the patient was admitted to our hospital with the complaint of loss of appetite. She was suspected of DIC because of thrombocytopenia, increased fibrin degradation product and prolonged prothrombin test. Abnormality in coagulation system is recognized in collagen disease. In this case coagulation system was activated and DIC occurred. In this case rheumatoid factor was positive. But she was suspected of complicating other collagen disease because she was poor in typical characteristics of rheumatoid arthritis, such as morning stiffness. SLE was diagnosed on the basis of renal injury, thrombocytopenia, positive anti-Sm antibody and positive antinuclaer antibody in this case. kn-abstract=播種性血管内凝固症候群（DIC）を合併した全身性エリテマトーデス（SLE）を経験したので報告する。症例は73歳女性。64歳時慢性関節リウマチ（RA）と診断された。1999年1月食欲低下を訴え当科受診した。血小板減少、FDP高値、PT上昇等よりDIC発症を疑った。膠原病では凝固系の異常を認めるが、本症例では凝固系が完進しDICを来したと考えられた。 本症例はリウマチ因子陽性であったが、朝のこわばり等典型的なRAの所見に乏しく他の膠原病の合併を疑い、腎障害、血小板減少、抗Sm抗体、抗核抗体陽性よりSLEと診断した。 en-copyright= kn-copyright= en-aut-name=TakataSingo en-aut-sei=Takata en-aut-mei=Singo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=1 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=2 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=3 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= en-aut-name=NiiyaKenji en-aut-sei=Niiya en-aut-mei=Kenji kn-aut-name=新谷憲治 kn-aut-sei=新谷 kn-aut-mei=憲治 aut-affil-num=9 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=慢性関節リウマチ (Rheumatoid arthritis) kn-keyword=慢性関節リウマチ (Rheumatoid arthritis) en-keyword=全身性エリテマトーデス (Systemic lupus erythematosus) kn-keyword=全身性エリテマトーデス (Systemic lupus erythematosus) en-keyword=播種性血管内凝固症候群 (Disseminated intravascular coagulation syndrome) kn-keyword=播種性血管内凝固症候群 (Disseminated intravascular coagulation syndrome) END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=73 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=4年間無治療にて経過を観察した高齢発症原発性胆汁性肝硬変症の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=症例は80才，女性。76才時［平成7年11月］より肝機能異常［アルカリフォスファターゼ高値］を認め，肝機能異常出現1年7ケ月後，血清学的検索で原発性胆汁性肝硬変症が疑われたが，無治療にて外来で経過を観察を行った。アルカリフォスファターゼ値は漸増傾向を示し，トランスアミナーゼ値の異常も伴ってきたため，平成12年11月精査目的で入院。組織検査等で無症候性原発性胆汁性肝硬変症［PBC］と診断した。PBCは中年・女性に好発する疾患で，高齢【特に後期高齢者］での発症は極めて稀である。4年間の自然経過も含め，興味深いと考えられたので報告する。 en-copyright= kn-copyright= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=1 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保﨑泰弘 kn-aut-sei=保﨑 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=NishidaNorikazu en-aut-sei=Nishida en-aut-mei=Norikazu kn-aut-name=西田典数 kn-aut-sei=西田 kn-aut-mei=典数 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科 en-keyword=原発性胆汁性肝硬変症 (primary biliary cirrhosis) kn-keyword=原発性胆汁性肝硬変症 (primary biliary cirrhosis) en-keyword=高齢 (elderly) kn-keyword=高齢 (elderly) en-keyword=自然経過 (natural course) kn-keyword=自然経過 (natural course) END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=76 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=マトリックスメタロプロテアーゼと膵疾患 kn-title=Matrix metalloproteinases (MMPs) and pancreatic diseases en-subtitle= kn-subtitle= en-abstract=マトリックスメタロブロテアーゼ（MMP）は，コラーゲン分解能を有し，種々の疾患との関連性が示唆されている。とりわけ,癌の浸潤，転移には密接な関係があるとされている。また，MMP阻害剤を癌の治療に用いる試みもなされている。本稿ではMMPと膵疾患の関連性，MMP阻害剤の膵癌への応用の可能性について総説する。 kn-abstract=Matrix metalloproteinases (MMPs) is a family of collagenolytic enzymesand are associated with many pathological conditions. Especially, MMPs have a strong relation with tumor progression and invasion. In this review, we focused on association of MMPs and pancreatic diseases, and a potential treatment of MMPs inhibitors for pancreatic cancer. en-copyright= kn-copyright= en-aut-name=YokoyamaMotohiro en-aut-sei=Yokoyama en-aut-mei=Motohiro kn-aut-name=横山元浩 kn-aut-sei=横山 kn-aut-mei=元浩 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=4 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=5 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学保険学科 affil-num=5 en-affil= kn-affil=岡山赤十字病院 affil-num=6 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=matrix metalloproteinase(MMP) kn-keyword=matrix metalloproteinase(MMP) en-keyword=tissue inhibitor of metalloproteinase(TIMP) kn-keyword=tissue inhibitor of metalloproteinase(TIMP) en-keyword=pancreatic cancer (膵癌) kn-keyword=pancreatic cancer (膵癌) en-keyword=chronic pancreatitis (慢性膵炎) kn-keyword=chronic pancreatitis (慢性膵炎) END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=84 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaiuation of spa therapy by questionnaire. Characteristics of patients from distant areas. kn-title=アンケート調査による温泉療法の評価　－遠隔地からの入院患者を対象に－ en-subtitle= kn-subtitle= en-abstract=Clinical evaluation of spa therapy was examined in 80 patients with respiratory disease and with joint pain including lumber pain, who came from distant areas (outside Tottori prefecture) and were admitted at Misasa Hospital by questionnaire in relation to a motive of admission, effects of spa therapy, dose of medication, a motive of discharge. In many of these patients, the age was over 60 years and duration of their admission was from two to three months. Seventy-one- (88.7%) of the 80 patients were admitted at our hospital because they were not satisfactory for the treatment of asthma which they had before. The number of patients from Hiroshima, Osaka, Kyoto, and Hyogo, prefectures was larger than the number from other distant areas. The results of the questionnaire suggest that improvement of symptoms and reduction of drugs used are ecpected by spa therapy. kn-abstract=1999年4月～12月の9ケ月間の遠隔地からの入院患者80名（痔痛性疾患47例，呼吸器疾患33例）を対象に，岡大三朝分院に来院した動機，入院前の状態，温泉療法の効果，薬剤の変化，退院決定の動機等について退院前にアンケート調査を行い検討を加えた。対象症例の年齢は60才以上の高齢者力て多く，入院期間は1ケ月～2ケ月末満が多い傾向であった。入院前の状態では，今までの治療に不満，限界を感じて来院している症例が71例（88．7％）を占めていた。地域別では広島，大阪，京都，兵庫からの来院か多く，その他18都府県に及んでいた。アンケート結果では，疾患別による若干の傾向と，温泉療法に対する評価として症状の改善が見られ，また，使用薬剤の減量の可能性が示唆された。 en-copyright= kn-copyright= en-aut-name=NishimuraNobuko en-aut-sei=Nishimura en-aut-mei=Nobuko kn-aut-name=西村伸子 kn-aut-sei=西村 kn-aut-mei=伸子 aut-affil-num=1 ORCID= en-aut-name=TerasakiKayo en-aut-sei=Terasaki en-aut-mei=Kayo kn-aut-name=寺崎佳代 kn-aut-sei=寺崎 kn-aut-mei=佳代 aut-affil-num=2 ORCID= en-aut-name=YamamotoSadae en-aut-sei=Yamamoto en-aut-mei=Sadae kn-aut-name=山本貞枝 kn-aut-sei=山本 kn-aut-mei=貞枝 aut-affil-num=3 ORCID= en-aut-name=YoshioKeiko en-aut-sei=Yoshio en-aut-mei=Keiko kn-aut-name=吉尾慶子 kn-aut-sei=吉尾 kn-aut-mei=慶子 aut-affil-num=4 ORCID= en-aut-name=NakamuraSumie en-aut-sei=Nakamura en-aut-mei=Sumie kn-aut-name=中村寿美江 kn-aut-sei=中村 kn-aut-mei=寿美江 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院二勤分院看護部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院二勤分院看護部 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院二勤分院看護部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院二勤分院看護部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院二勤分院看護部 affil-num=6 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=遠隔地 (distant area) kn-keyword=遠隔地 (distant area) en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=アンケート (questionaire) kn-keyword=アンケート (questionaire) en-keyword=呼吸器疾患 (respiratory disease) kn-keyword=呼吸器疾患 (respiratory disease) en-keyword=疼痛性疾患 (pain disease) kn-keyword=疼痛性疾患 (pain disease) END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=89 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=通院患者の温泉プール訓練についての満足度と期待度 en-subtitle= kn-subtitle= en-abstract= kn-abstract=通院患者の温泉プール利用者95名を対象にアンケート調査し，主に訓練に対する満足度と期待度について調査した。 結果は有効回答85名，対象者の年齢65歳以上58名（68％）65歳末満27名（32％），疾患別では呼吸器疾患39名（45．9％）療病性疾患29名（34．1％）その他の疾患17名（20％）であった。 t検定の結果有意差（P＜0．05）があったのは，療病性疾患群では呼吸器疾患群に比べ期待度が高い，訓練が頻回な群で期待度が高い，指導あり群で満足度が高い，であった。年齢別での効果では65歳末満と65歳以上の比較で有意差はなかったが，高齢者（65歳以上）において高い傾向が見られた。温泉プール訓練は高齢者に効果的な訓練と考えられ，より効果を高めるための課題として訓練指導を充実する必要がある。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石田美枝子 kn-aut-sei=石田 kn-aut-mei=美枝子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=温泉プール訓練 kn-keyword=温泉プール訓練 en-keyword=外来通院患者 kn-keyword=外来通院患者 en-keyword=満足度 kn-keyword=満足度 en-keyword=期待度 kn-keyword=期待度 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=94 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=運動器疾患入院状況 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakamuraSumie en-aut-sei=Nakamura en-aut-mei=Sumie kn-aut-name=中村寿美江 kn-aut-sei=中村 kn-aut-mei=寿美江 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=看護部 en-keyword=看護部 kn-keyword=看護部 en-keyword=入院状況 kn-keyword=入院状況 en-keyword=運動器疾患 kn-keyword=運動器疾患 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for patients with asthma. A study on 437 patients with asthma admitted for last 5 years. kn-title=気管支喘息に対する温泉療法.最近5年間(1994年-1998年)の入院症例437例を対象に en-subtitle= kn-subtitle= en-abstract=The parients with asthma who were admitted at our hospital for last 5 years (1994-1998) were examined in relation to age and areas where patients came. 1. Of 664 patients with respiratory disease admitted for last 5 years, 437 patients (65.8% ) had asthma. The frequency of asthma in all patients with respiratory disease was the highest (74.4% ) in 1995, and decreased in 1997 and 1998 (60.7% ). 2. The number of patients with asthma from distant areas (outside Tottori prefecture) was constantly larger than the number of those inside Tottori prefecture in each year. The number of patients from Okayama, Osaka, Hyogo, Hiroshima, Yamaguchi, and Ehime was larger than the number from other distant areas. 3. Regarding the distribution of age of these patients, the number of patients over the age of 60 was more frequently observed, regardless of the area where patients came. Larger number of patients over the age of 70 (35.1% ) was found in those inside Tottori prefecture, while the number of patients between the ages of 60 and 69 (37.7% ) was larger in those from distant areas. kn-abstract=1994年1月より1998年12月までの5年間に当院へ入院した呼吸器疾患のなかで気管支喘息を対象に,年齢,地域分布などの経年変化について検討を加えた｡1.最近5年間に当院へ入院した呼吸器疾患患者は664例で,このうち,気管支喘息は437例(65.8% )であった｡呼吸器疾患のなかで気管支喘息に占める割合の経年変化では,1995年度が最も高く(74.4% ),1997,1998年度にはやや低下(ともに60.7% )の傾向が見られた｡2.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,いずれの年度においても50% 以上(平均57.3% )であった｡また,岡山,大阪,兵庫,広島,山口,愛媛県などからの入院症例が多い傾向か見られた。3.年齢別検討では,いずれの地域においても,高齢者の入院症例か多く,鳥取県内では70才以上の症例の頻度(平均35.1% )が,また遠隔地(鳥取県外)では60-69才の症例の頻度(平均37.7% )が高い傾向か見られた｡ en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=8 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 en-keyword=気管支喘息 (asthma) kn-keyword=気管支喘息 (asthma) en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=高齢患者 (aged patients) kn-keyword=高齢患者 (aged patients) en-keyword=遠隔地 (distant area) kn-keyword=遠隔地 (distant area) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=9 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ⅰ型アレルギー反応および副腎皮質ホルモンは気管支喘息における末梢血白血球のロイコトリエンB4およびC4産生に影響をおよぼす kn-title=IgE-mediated allergy enhances and glucocorticoids inhibit the generation of leukotrienes B4 and C4 by peripheral leucocytes in patients with asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息71例および健康人23名を対象に､Ca ionophore A23187刺激時の末梢血白血球のロイコトリエンB4 (LTB4)およびC4(LTC4)の産生能について検討を加えた｡なお､71例中ステロイド依存性重症難治性喘息(SDIA)は22例であった。1.アトピー性､16非SDIA症例におけるLTB4､LTC4産生は､健康人と比べ有意に高い値を示したが､非アトピー性喘息では健康人との間に有意の差は見られなかった｡また､アトピー性喘息では､SDIA症例において非SDIA症例に比べ､LTB4､LTC4産生が有意に抑制されていた｡2.非SDIA症例では､アトピー性､非アトピー性を問わず､LTC4産生は､非発作時に比べ発作時に有意に亢進した状態であった｡しかし､LTB4産生には､非発作時､発作時との間に有意の差は見られなかった｡3.SDIA症例では､LTB4､LTC4産生と発作との有意の関連は見られなかった｡以上の結果より､IgE にmediateされるアレルギー反応や喘息発作はLTB4､LTC4産生に促進的に､また副腎皮質ホルモンは抑制的に作用することが示唆された｡ kn-abstract=The generation. of leukotrienes 84 (LT84) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 71 patients with asthma (42 with atopic and 29 with nonatopic asthma) and 23 healthy controls. Of these patients,22 had SDIA (steroid-dependent intractable asthma). 1. The generation of LT84 and LTC4 by leucocytes was significantly more enhanced in patients with atopic, non-SOIA asthma than in healthy subjects, but not in patients with nonatopic asthma. The generation of LT84 and LTC4 in atopic asthma was significantly more decreased in patients with SOIA than in those with non-SOIA. 2. The LTC4 generation was significantly larger in attack stage than in attack-free stage of patients with atopic and nonatopic asthma when they had not SOIA. However, no significant difference was found in LT84 generation between attack and nonattack stages in these patients. 3. In patients with SOIA, no significant differences were observed in the generation of LT84 and LTC4 between attack and nonattack stages. The results suggest that IgE-mediated allergy and asthma attacks enhance and glucocorticoids inhibit the generation of LT84 and LTC4 by leucocytes. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=8 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name=小出典男 kn-aut-sei=小出 kn-aut-mei=典男 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=10 en-affil= kn-affil=医学部臨床検査医学 affil-num=11 en-affil= kn-affil=医学部臨床検査医学 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=LT84 kn-keyword=LT84 en-keyword=LTC4 kn-keyword=LTC4 en-keyword=IgE-mediated allergy kn-keyword=IgE-mediated allergy en-keyword=glucocorticoids kn-keyword=glucocorticoids END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=17 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における胸部HRCT所見の臨床[光延文裕1]的意義 kn-title=Evaluation of low attenliation area (LAA) of the lungs in patients with reversible airway obstruction by high resolution computed tomography (HRCT). en-subtitle= kn-subtitle= en-abstract=【目的】気管支喘息症例において胸部HRCTを用いて% LAA(Lowattenuationarea)を評価し,臨床病態との関連を検討する｡ 【対象と方法】気管支喘息症例81例ならびに健常者22例を対象とした｡大動脈弓部,下葉分岐部,横隔膜上3cmの3スライスを撮影し,胸部CT値の演算によりCT値が-950HU以下の% LAA,さらに3スライス中の最大% LAAと3スライスの平均CT値を算出した｡その値と年齢,発症年齢,罹病期間,性別,喫煙歴,重症度,病型,肺機能との関連を検討した｡【結果】1.最大% LAAは平均CT値と強い相関を示した(r=-0.916,p<0.0001)。2.最大% LAAは喫煙喘息患者において非喫煙喘息患者,喫煙ならびに非喫煙健常者に比較して喫煙者において有意に高値を示した｡% LAAは喫煙者,非喫煙者ともに重症例において有意に高値を示した｡3.最大% LAAは肺機能では1秒率(r=-0.611,p<0.0001),全肺気量(r=-0.391,p<0.0001)と有意な相関を示した｡4.最大% LAAは喘息の重症度とは有意の竿間を示したが,病型とは関連は見られなかった｡ 【考案】喘息患者におけるHRCTによる最大% LAAは喫煙,重症度,肺機能と関連を示しており,気管支喘息の臨床病態を反映する可能性が示唆された｡ kn-abstract=The significance of the low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) has not been determined in patients with asthma. We examined the relationship between the percentage of lung area with CT numbers lower than -950HU (% LAA) and the mean CT number in 81 patients with reversible airway obstruction (asthma) and in 22 healthy subjects, as well as the relationship between maximal % LAA and various parameters of pulmonary function, smoking history, disease severity and allergic type in the asthmatic subjects. The mean CT number was obtained by scans at three anatomic levels, and maximal % LAA was the % LAA which had the largest value of those measured at the three anatomic levels of the lung. We found that: 1. The mean CT number was closely related to the maximal % LAA of the lungs in all subjects studied (r= -0.916, p 1200mg/dℓ). 1. The levels of serum IgA and IgM were significantly decreased in group A compared to the levels in group B patients. 2. The number of blood lymphocytes was also significantly lower in group A than in group B patients. However, the number of blood neutrophils was not different between the two asthma groups. 3.The number of BAL lymphocytes was significantly lower in group A than in group B patients. 4. BAL neutrophilia (more than 1.5×10 (4)/mℓ) was observed in 6 of the 17(35.3%) patients in group A, but not observed in any patients in group B. The number of BAL neutrophils was significantly greater in group A than in group B　patients. These results suggest that there is a correlation between immunosuppression by glucocorticoids and BAL neutrophilia in patients with bronchial asthma. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=10 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=immunosuppression (免疫抑制) kn-keyword=immunosuppression (免疫抑制) en-keyword=BAL neutrophilia (BAL好中球増多) kn-keyword=BAL neutrophilia (BAL好中球増多) en-keyword=glucocorticoids (副腎皮質ホルモン) kn-keyword=glucocorticoids (副腎皮質ホルモン) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=19 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における気道内リンパ球の出現とその意義.IgE系反応との関連について. kn-title=Lymphocytes in the airways of patients with bronchial asthma. Is there any relationship to IgE-mediated allergic reaction. en-subtitle= kn-subtitle= en-abstract=気管支喘息を対象に,気管支肺胞洗浄液(BALF)中のリンパ球の出現頻度と,IgE系反応および換気機能との関連について検討を加えた｡対象は,同年齢の2つのグループ,すなわち,BALF中リンパ球出現頻度30%以上の症例(グループA)と10%以下の症例(グループB)に分けて,それぞれ11例ずっで比較検討を行った｡グループAでは,11例中3例がアトピー型,4例が非アトピー型であった。血清IgEが300IU/ml以上の症例(いずれも50才以上)では,100IU/ml以下の症例に比べ,BALF中リンパ球の出現頻度は,有意に高い傾向を示した｡一方,グループBの11例では,アトピー型5例,非アトピー型4例であった｡% Ⅴ(25)値は,グループAではアトピー型で,非アトピー型に比べ有意に高い値を示した｡これらの結果は,50才以上の症例では,IgE系の反応がリンパ球の出現頻度を増強させること,そして,非アトピー型では,リンパ球の出現頻度と% Ⅴ(25)笛値との間にある程度の関連が見られることを示唆しているものと考えられた。 kn-abstract=Relationship of the proportion of lymphocytes in　bronchoalveolar lavage (BAL) fiutd to IgE-mediated reactions and to ventilatory function was studied in two age-matched asthma groups : group A of 11 subjects with BAL lymphocytes over 30% and group B of 11 subjects with BAL leyphocytes less than 10%. Of the eleven subjects in group A, 3 (27.3%) were atopic and 4 (36.4%) were non-atopic. The proportion of BAL lymphocytes in subjects with serum IgE level more than 300 IU/ml, who were all older than 50 years, was significantly higher than that in subjects with serum IgE less than 100 IU/ml in group A (p<0.05). While of the eleven subjects of group B, 5 (45.5%) were atopic and 4 (36.4%) were non-atopic. The value of % V(25) was significantly higher in the atopics compared with the non-atopics in group A (p<0.05), although no significant difference was found in the value of % V(25) between the two asthma types in group B. The results show that an increased number of lymphocytes in BAL fluid may be enhanced by IgE-mediated allergic reactions in the elderly, and that the decreased value of % V(25) may be associated withan increased number of lymphocytes in BAL fluid in non-atopics. en-copyright= kn-copyright= en-aut-name=TanizakiYosihiro en-aut-sei=Tanizaki en-aut-mei=Yosihiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=6 ORCID= en-aut-name=HonkeNaoko en-aut-sei=Honke en-aut-mei=Naoko kn-aut-name=本家尚子 kn-aut-sei=本家 kn-aut-mei=尚子 aut-affil-num=7 ORCID= en-aut-name=KusauraYasuhiro en-aut-sei=Kusaura en-aut-mei=Yasuhiro kn-aut-name=草浦康浩 kn-aut-sei=草浦 kn-aut-mei=康浩 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科　 en-keyword=Lymphocytes (リンパ球) kn-keyword=Lymphocytes (リンパ球) en-keyword=BAL fluid (BAL液) kn-keyword=BAL fluid (BAL液) en-keyword=IgE antibody (IgE抗体) kn-keyword=IgE antibody (IgE抗体) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=11 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息におけるActivated Tリンパ球について,喘息発作との関連 kn-title=Activated blood T cells in patients with bronchial asthma. Relationship to asthmatic cycle. en-subtitle= kn-subtitle= en-abstract=気管支喘息14例を対象に,末梢血CD4(+)リンパ球の頻度,CD4／CD8比およびIL2R(+)Tリンパ球の頻度について,喘息発作との関連のもとに検討を加えた｡1.CD4(+)リンパ球の頻度は,非発作時の症例で最も高く,喘鳴のみの症例,発作の見られる症例へと順次低くなる傾向が見られたが,推計学的には有意の差は見られなかった｡CD4/CD8比も同様に,非発作時に最も高く,発作を有する症例では非発作時に比べ低い値を示したが,推計学的には有意の差は見られなかった｡2.IL2R(+)Tリンパ球(activated Tリンパ球)の頻度は,非発作時の症例で最も低く(3.5±1.1%),喘鳴のみをともなう症例(3.8±1.1%),発作の見られる症例(5.8±1.9%)へと順次高くなる傾向を示し,発作のある症例では,非発作および喘鳴のみの症例に比べ有意に高い値 を示した｡また,非発作時と発作のある時期にIL2R(+)Tリンパ球を観察し得た5症例では,非発作時2.9±0.8%,発作のある時期6.6±1.1%であり,発作のある時期に有意の高値を示した(p<0.001)。これらの結果は,発作のある時期にはactivated Tリンパ球の頻度が増加すること,そして,この増加はactivated Tリンパ球が喘息発作の病態と密接な関連を有していることを示唆するものと考えられた｡ kn-abstract=The number of CD4(+) T-Iymphocytes, CD4/CD8 ratio, and the number of IL2R(+) T-Iymphocytes (CD25) were examined in 14 patients with bronchial asthma, and the results were compared in three different asthma stages : symptom-free stage, wheeze stage, and attack stage. 1. The proportion of blood CD4(+) T-lymphocytes was more decreased in patients with asthma attacks than in those without symptoms. The CD4/CD8 ratio was also more　decreased in patients with attacks than in those without symptoms. However, these differences were not significant. 2. The proportion of blood activated T cells (IL2R(+) cells, CD25) was significantly increased in patients with attacks than in those without symptoms. The proportion of activated T cells in 5 asthma patients was 2.9±0.8% in　symptom-free stage and 6.6±1.1% in attack stage(p<0.001). These findings show that numbers of activated T-lymphocytes in peripheral blood were increased during asthma attacks, and this increase suggests the participation of　activated T cells in the pathogenesis of asthma. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=10 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=11 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=CD4(+) T cells (CD4(+)リンパ球) kn-keyword=CD4(+) T cells (CD4(+)リンパ球) en-keyword=CD4／CD8 ratio (CD4／CD8比) kn-keyword=CD4／CD8 ratio (CD4／CD8比) en-keyword=IL2R(+) T cells (IL2R(+)Tリンパ球) kn-keyword=IL2R(+) T cells (IL2R(+)Tリンパ球) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=14 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における気道内への好酸球の出現とその意義. 過分泌と関連して. kn-title=Role of eosinophils in the airways of patients with atopic asthma. Relationship to mucus hypersecretion en-subtitle= kn-subtitle= en-abstract=アトピー型気管支喘息のなかから,気管支肺胞洗浄液(BALF)中の好酸球の出現頻度が20%以上の症例(グループA)と5%以下の症例(グループB)の2群を選び出し,それぞれの換気機能および喀痰量を比較検討した｡その結果,換気機能には両群間に有意の差は見られなかったが,1日喀痰量は,BALF中好酸球の著明増多を示すグループAにおいて有意に多い傾向が見られた｡これらの結果は,BALF中好酸球増多と過分泌との間にはある程度の関連があることを示しているものと考えられた｡ kn-abstract=A correlation between the proportion of eosinophils in bronochoalveolar lavage (BAL) fluid and amount of expectoration was examined in patients with atopic asthma. The subjects were divided into two groups : cases with high proportion (20% of more) (group A) and low proportion (less than 5%) (group B) of eosinophils in the BAL fluid. Any significant difference was not paesent in the value of each ventilatory parameter between the two groups. The amount of expectoration/day was significantly higher in group A compared with group B (p<0.001). These results suggest that eosinophilia in BAL fluid correlates to mucus hypersecretion in the airways of patients with atopic asthma. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部第二内科　 en-keyword=Eosinophilia (好酸球) kn-keyword=Eosinophilia (好酸球) en-keyword=Hypersecretion (過分泌) kn-keyword=Hypersecretion (過分泌) en-keyword=BAL fluid (BAL) kn-keyword=BAL fluid (BAL) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=24 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における気道炎症反応の臨床的意義｡慢性閉塞性細気管支炎との比較検討 kn-title=Clinical significance of airway inflammation in bronchcial asthma. Comparison with chronic obstructive bronchiolitis. en-subtitle= kn-subtitle= en-abstract=気管支喘息28例および慢性閉塞性細気管支炎9例を対象に,気道炎症反応の臨床的意義について検討を加えた｡1.気管支肺胞洗浄(BAL)液中の総細胞数は,慢性閉塞性細気管支炎において著明に増加しており(51.0×10(6)),気管支喘息(9.6×10(6))との間に有意の差が見られた｡2.BAL液中マクロファージの頻度は気管支喘息において,慢性閉塞性細気管支炎に比べ有意に高い値を示したが,絶対数での比較では両疾患群間に有意の差は見られなかった｡ 3.BAL液中リンパ球の頻度は,気管支喘息においてやや高い傾向が見られたが,絶対数の比較では慢性閉塞性細気管支炎において有意に高い値であった｡ 4.BAL液中の好中球は,その頻度および絶対数とも慢性閉塞性細気管支炎において著明に増加しており,これは気管支喘息と比べ有意に高い値であった｡ 5.BAL液中好酸球の頻度および絶対数は,気管支喘息においてやや高い値であったが,両疾患群間に有意の差は見られなかった｡以上の結果より,気管支喘息における気道炎症反応は,慢性閉塞性細気管支炎ほど高度ではない ことが明らかにされた。 kn-abstract=Clinical significanoce of airway inflammation was assessed in 28 patients with bronchial asthma, and the results were compared with those in 9 patients with chronic obstructive bronchiolitis (COB). 1. Total cell number in bronchoalveolar lavage(BAL) fluid was markedly increased in patients with COB (51.0×10(6)), which was significantly greater than that in those with bronchial asthma (9.6×10(6) ). 2. The proportion of BAL macrophages was significantly higher in patients with bronchial asthma than in those with COB. However, the, absolute number of BAL macrophages was not significantly different between them. 3. The proportion of BAL lymphocytes was higher in patients with bronchial asthma than in those with COB, but this difference was not signifcant. In contrast, the absolute number of BAL lymphocytes was significantly greater in patients with COB than in those with bronchial asthma. 4. The proportion and the number of BAL neutrophils were markedly increased in patients with COB compared to those with bronchial asthma. 5. The proportion and the number of BAL eosinophils were higher in patients with bronchial asthma than in those with COB, although these defferences were not significant. The results suggest that airway inflammation in bronchial asthma is not so intensive as that in COB. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=12 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=13 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=airway inflammation (気道炎症反応) kn-keyword=airway inflammation (気道炎症反応) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=chronic obstructive bronchiolitis (慢性閉塞性細気管支炎) kn-keyword=chronic obstructive bronchiolitis (慢性閉塞性細気管支炎) en-keyword=lymphocytes (リンパ球) kn-keyword=lymphocytes (リンパ球) en-keyword=neutrophils (好中球) kn-keyword=neutrophils (好中球) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=25 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における気道内への好中球の出現とその意義　換気機能と関連して kn-title=Neutrophils in the airways of patients with bronchial asthma. Relationship to ventilatory function en-subtitle= kn-subtitle= en-abstract=気管支喘息を対象に,年令をmatchさせた2つのグループ,すなわち,気管支肺胞洗浄液(BALF)中の好中球の出現頻度が20%以上の8症例(グループA)と,BALF中の好中球の出現頻度が5%以下の8症例(グループB)における換気機能について比較検討を行った｡6つの換気パラメーターは,全般的にグループAにおいてグループBに比べ低い傾向が見られ,FEV(1.0%),% MMF,% V(50)および% V(25)値は,いずれもグループAにおいて有意に低い値が示された｡これらのパラメーターのうち,% V(25)値はグループBに比べグループAにおいて著明に低い値が示された｡これらの結果は,気道における換気障害,特に小ないし細気管支領域の換気障害は,BALF中の好中球の出現頻度とある程度関連していることを示すものと考えられた。 kn-abstract=Ventilatory function was compared between two age-matched asthma groups : group A (study group) consists of 8 patients with bronchial asthma with marked neutrophilia (20% or more) in the BAL fluid and group B (control group) of 8 patients with neutrophils (less than 5% of total BAL cells). The values of six ventilatory parameters were lower in group A than in group B, and a significant difference was found in FEV(1.0%), % MMF, % V(50) and % V(25) between groups A and B. Of these parameters, the value of % V(25) was markedly decreased in group A compared with group B. The results show that ventilatory dysfunction in airways, especially in small airways, is closely correlated to increased number of neutrophils in BAL fluid. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=6 ORCID= en-aut-name=HonkeNaoko en-aut-sei=Honke en-aut-mei=Naoko kn-aut-name=本家尚子 kn-aut-sei=本家 kn-aut-mei=尚子 aut-affil-num=7 ORCID= en-aut-name=KusauraYasuharu en-aut-sei=Kusaura en-aut-mei=Yasuharu kn-aut-name=草浦康浩 kn-aut-sei=草浦 kn-aut-mei=康浩 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科　 en-keyword=ventilatory function (換気機能) kn-keyword=ventilatory function (換気機能) en-keyword=neutrophils in BAL fluid (好中球, BAL) kn-keyword=neutrophils in BAL fluid (好中球, BAL) en-keyword=small airways (細気管支) kn-keyword=small airways (細気管支) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=31 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息におけるハウスダストアレルギー. 血清IgE値とIgE抗体価と年齢との関連 kn-title=House dust mite allergy in patients with　bronchial asthma. Serum IgE levels and IgE antibody values in relation to patient age. en-subtitle= kn-subtitle= en-abstract=ハウスダストが原因抗原であるアトピー型気管支喘息50例を対象に,血清IgE値とIgE抗体価を年齢との関連のもとに検討した｡1.IgE抗体価は10-19才の年齢層の症例において最も高く,一方40才以上の症例では全般的に低い傾向が見られた｡2.10-19才の年齢層の症例では,IgE抗体価の高値と同時に血清IgE値も高い値を示したが,40才以上の症例では,IgE抗休価および血清IgE値いずれも10-19才の症例に比べ全般的に低い値を示した｡9才以下の症例では,IgE抗体価の高値にもかかわらず,血清IgE値は比較的低く,500IU/ml以下を示した症例が10例中5例に観察された｡これらの結果は,若年症例では,IgE抗体の産生亢進と総IgEの産生亢進が同時に見られること が多いが,9才以下ではIgE抗体産生亢進に総IgE産生亢進が必ずしもともなわない場合があることを示している｡また,40才以上の症例では,ハウスダストに対する過敏性は有しているものの,IgE抗体価および血清IgEは全般的に低い値を示す傾向が示唆された｡ kn-abstract=Serum IgE levels and IgE antibody values in relation to patient age were examined in 50 patients with house dust mite (HDm) sensitive asthma, 1. IgE antibody values to HDm were highest in patients between the ages of 10 and 19, and the　values generally low in those over the age of 40. 2. High IgE antibody values to HDm　were accompanied by high serum IgE levels in patients between 10 and 19. IgE antibody values and serum IgE levels were in general low in patients over age 40. In patient under　age 9, serum IgE levels were less than 500 IU/ml in 5 of the 10 subjects despite an increased value of IgE antibodies to HDm. These results suggest that an increased　production of IgE antibodies to HDm is usually accompanied by an increased production of total IgE in younger subjects. However, an increase in production of IgE antibodies is not always related to an increase in production of total IgE in patients under age 9. The results also show that production of IgE antibodies to HDm and total IgE is in general low in older patients despite the hyperreactivity to HDm. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=10 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=11 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Serum IgE (血清IgE) kn-keyword=Serum IgE (血清IgE) en-keyword=IgE antibodies (IgE抗体) kn-keyword=IgE antibodies (IgE抗体) en-keyword=house dust mite (ダニ) kn-keyword=house dust mite (ダニ) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=75 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=老年者気管支喘息における液性および細胞性免疫反応について kn-title=Humoral and cellular immune response in elderly patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息における液性および細胞性免疫反応について,老年者気管支喘息,老年者健常人,および若年者気管支喘息の間で比較検討を行った｡1.まず,液性免疫では,血清IgE値高値,ハウスダストやカンジダに対するIgE抗体陽性などのIgE系反応は,老年者気管支喘息においては明らかに観察されたが,老年者健常人では全く観察されなかった｡血清IgGおよびIgA値には3者間に有意の差は見られなかったが,血清IgMは,若年者喘息に比べ老年者喘息で有意に低い値を示した｡2.ハウスダストやカンジダに対するIgE抗体は老年者喘息において老年者健常人に比べより高い頻度で陽性であったが,一方,ハウスダストに対するIgG(4)抗体は3者聞に有意の差は見られなかった｡また,カンジダに対するIgG(4)抗体は,老年者喘息および健常人において,若年者喘息に比べ有意の高値を示した｡しかし,老年者の喘息と健常人との間には有意の差は見られなかった｡3.PPDによる遅延型皮膚反応は,若年者喘息に比べ老年者喘息において有意の減弱傾向を示した｡これらの結果は,老年者喘息はIgE系反応を有していること,そして,加齢による免疫反応の変化の影響を受けること,を示している｡ kn-abstract=Humoral and cellular immune responses in bronchial asthma were examined by comparing the results of older asthmatics (group OA) with those of older healthy subjects (group OH) and of younger asthmatics (group YA). In humoral immune response, IgE-mediated immune system expressed by elevated serum IgE levels and IgE antibodies for house dust mite (HDm) and/or Candida albicans was clearly found in older asthmatics, while there was no finding showing the presence of IgE-mediated immune response in older healthy subjects. There was no significant difference in levels of serum IgG and IgA among the three groups. However, the serum IgM level was significantly lower in older asthmatics than in younger asthmatics. IgE antibodies to HDm and/or Candida albicans were more frequently found in older asthmatics compared with older healthy subjects. In contrast, IgG(4) antibodies to HDm were not different among the three groups. IgG(4) antibodies to Candida albicans were significantly higher in both older groups than in younger group. However, there was no significant difference between asthmatic and healthy subjects in the elderly. Delayed skin reaction to PPD was significantly more decreased in older asthmatics. These results show that bronchial asthma in the elderly is characterized by the presence of IgE-mediated immune response and by the changes of immune response with aging. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=12 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=13 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=IgE kn-keyword=IgE en-keyword=IgG(4) kn-keyword=IgG(4) en-keyword=Immunoglobulings (免疫グロブリン) kn-keyword=Immunoglobulings (免疫グロブリン) en-keyword=PPD kn-keyword=PPD en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) en-keyword=加齢 kn-keyword=加齢 END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=30 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Correlations between bone mineral density measured by QCT and risk factors of Osteoporosis kn-title=QCTによる骨塩量測定と骨粗鬆症のリスクファクター en-subtitle= kn-subtitle= en-abstract=Bone mineral density (BMD) was measured in 143 females aged 27 to 85 years old to investigate the correlations between BMD and several factors such as age, height, presence of rheumatoid arthritis and corticosteroid or bone intensifying drug therapy. 1) BMD values decreased with aglng and the most remarkable decrease was observed at the age of latter half of 40's to 60's. 2) Women with slim and low stature tended to have low BMD values. 3) BMD values of women with steroid therapy were significantry lower than those without corticosteroid at the age of 50's (p<0.01). However, further study is necessary to confirm the effect of drugs on BMD. kn-abstract=27～85才の女性143例における骨塩量を,定量的QCT法 (quantitative computed tomography)を用いて測定し,年令,身長,体重及び原疾患(慢性関節リウマチ),使用薬剤(ステロイド･骨強化剤)の因子の骨塩量に及ぼす影響について検討した｡その結果,1)加令とともに骨塩量は低下するが,特に40才代後半から60才代にかけての低下が顕著であり,また, 他因子の影響を受けやすい｡2)体型的因子としては.痩せ型で低身長の人に低値の傾向がある｡3)ステロイド使用の有無における検討において,特に50才代で使用群が著明に低値であることが明らかとなった｡また,薬剤の因子の考察に関しては,さらに経時的検討か必要であると思われた｡ en-copyright= kn-copyright= en-aut-name=HonkeNaoko en-aut-sei=Honke en-aut-mei=Naoko kn-aut-name=本家尚子 kn-aut-sei=本家 kn-aut-mei=尚子 aut-affil-num=1 ORCID= en-aut-name=KusauraYasuhiro en-aut-sei=Kusaura en-aut-mei=Yasuhiro kn-aut-name=草浦康浩 kn-aut-sei=草浦 kn-aut-mei=康浩 aut-affil-num=2 ORCID= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=6 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=9 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=10 ORCID= en-aut-name=NakaiMutsuro en-aut-sei=Nakai en-aut-mei=Mutsuro kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=11 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=12 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 en-keyword=骨粗鬆症 (Osteoporosis) kn-keyword=骨粗鬆症 (Osteoporosis) en-keyword=定量的コンピューター断層法 (QCT (quantitative computed tomograpy)) kn-keyword=定量的コンピューター断層法 (QCT (quantitative computed tomograpy)) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=36 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息の臨床分類とその細胞性および液性因子の特徴 kn-title=Characteristics of humoral and cellular factors participating in onset mechanism of asthma in　relation to clinical types classified by symptoms. en-subtitle= kn-subtitle= en-abstract=気管支喘息72例を対象に,その臨床病態の特徴を,気道炎症性の細胞および化学伝達物質の観察により検討した｡1.気道反応の特徴を換気機能の面から検討すると,II細気管支閉塞型において,MMF,V(50)やV(25)などの小ないし細気管支領域の換気障害を示すパラメーターの値は,Ia型,Ib型に比べ 有意の低下を示した｡2.気道細胞反応では,II型において,他の臨床病型に比べ,BAL液中好中球の出現頻度の有意の増加が観察された(Ia, p<0.001 ; Ib, p<0.01)｡好酸球の出現頻度は,Ib過分泌型において著しい増加傾向を示す症例が見られたが,その平均出現頻度には3病型間に有意の差は見られなかった｡3.好中球からのメジェー夕ー遊離では,ヒスタミン遊離は,Ia単純性気管支撃縮型において最も高い値が示されたが,推計学的には3病型間に有意の差は見られなかった｡ロイコトリエンC(4)では,Ia型においてII型に比べ有意に高い遊離が観察された(p<0.05)｡ロイコトリエンB(4)遊離には,3病型間に差は見られなかった｡ kn-abstract=Characteristics of each asthma type classified by clinical symptoms and　findings were studied in 72 patients with bronchial asthma. 1. Ventilatory function tests showed that the values of % MMF, % V(50) and % V(25) were significantly lower in patients with bronchiolar obstruction (type II) compared to the values of those with simple bronchoconstriction type (type Ia) and those with bronchoconstriction + hypersecretion (type Ib). 2. The proportion of neutrophils in bronchoalveolar lavage (BAL) fluid was significantly higher in type II than in type Ia and type Ib. Several　patients with type Ib showed higher proportion of BAL eosinophils. 3. The release of LTC(4) from leucocytes was significantly lower in type II compared with type Ia and type Ib. There was no significant difference in the release of histamine and LTB(4) among the three asthma types. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=NakagiriYoshiyasu en-aut-sei=Nakagiri en-aut-mei=Yoshiyasu kn-aut-name=中桐善康 kn-aut-sei=中桐 kn-aut-mei=善康 aut-affil-num=10 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=11 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=Asthma classification kn-keyword=Asthma classification en-keyword=BAL fluid kn-keyword=BAL fluid en-keyword=chemical mediators kn-keyword=chemical mediators END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=43 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=抗原および Ca ionophore A23187 刺激時におけるアトピー型気管支喘息末梢血好塩基球の運動能 kn-title=Difference in motility of basophilic, granulocytes from atopic subjects following antigen- and Ca inophore A23187-stimulation en-subtitle= kn-subtitle= en-abstract=アトピー型気管支喘息末梢血好塩基球を用い,抗原および Ca ionophore A23187 刺激時のヒスタミン遊離およびその形態的変化について比較検討した｡1.抗原刺激時には, Ca ionophore A23187 刺激時に比べ,好塩基球からのヒスタミン遊離および好塩基球数の減少の程度は,より急激でかつ高度であった｡2.好塩基球の形態的変化,すなわち,長経/短経比の増大,限局性顆粒あるいは偽足を有する好塩基球の出現頻度の増加などの運動能の亢進を示唆する好塩基球の形態的変化は, Ca ionophore A23187 に比べ抗原刺激時により高度であった｡一方,平均直径の増大,5個以上の空砲を有する好塩基球の出現頻度の増加などの,むしろ膨化傾向を示唆する好塩基球の形態的変化は,抗原刺激時に比べ, Co ionophore A23187 刺激時により高度であった｡これらの結果より,抗原刺激によるIgE受容体のbridgingが,好塩基球を活性化し,運動能の亢進をひき起こすものと判断された。 kn-abstract=We examined histamine release and morphological changes in basophilic granulocytes from atopic subjects, in response to stimulation with antigen and Ca ionophore A23187. 1. Histamine release and a reduction in the rumber of basophils were more rapid and greater in extent at an early stage of antigen stimulation compared with Ca ionophore A23187 stimulation. 2. Morphological changes in basophils, represented by increased motility, in terms of an increased ratio of short to long axis diameter (L/S ratio), as well as the increased frequency of basophils with localized granules and those with pseudopods, were more often observed antigen stimulation than with Ca ionophore A23187 stimulation. In contrast, morphogical changes in which basophils appeared swollen, showing an increased mean cell diameter and an increased frequency of cells with 5 vacuoles or more were more predominant with Ca ionophore A23187 than with antigen stimulation. The results obtained here show that bridging of IgE receptors is essential to activate basophils and induce increased motility in these cells. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川二郎 kn-aut-sei=中川 kn-aut-mei=二郎 aut-affil-num=7 ORCID= en-aut-name=SodaRyo en-aut-sei=Soda en-aut-mei=Ryo kn-aut-name=宗田良 kn-aut-sei=宗田 kn-aut-mei=良 aut-affil-num=8 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=histamine release (ヒスタミン遊離) kn-keyword=histamine release (ヒスタミン遊離) en-keyword=increased basophil motility (好塩基球の運動能の亢進) kn-keyword=increased basophil motility (好塩基球の運動能の亢進) en-keyword=bridging of IgE receptors (LgE 受容体) kn-keyword=bridging of IgE receptors (LgE 受容体) en-keyword=antigen (抗原) kn-keyword=antigen (抗原) en-keyword=Ca ionophore A23187 kn-keyword=Ca ionophore A23187 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=83 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=老年者気管支喘息における気道炎症細胞.喘息重症度と関連した気道細胞反応の特徴 kn-title=Airway inflammation in elderly patients with bronchial asthma. Different airway inflammatory cell response related to disease severity. en-subtitle= kn-subtitle= en-abstract=70才以上の老年者気管支喘息11例(平均年齢71.4才)を対象に,重症度と気道細胞反応との関連について検討を加えた｡なお,対照として50才以下の喘息症例11例(平均年齢33.5才)を選んだ｡1.老年者の軽症型喘息における気管支肺胞洗浄(BAL)液中の出現細胞の頻度は,マクロファージが86.2%,リンパ球が11.0%,好中球が1.9%,好酸球が0.9%,好塩基性細胞が0.08%であった｡BAL液中の好中球,好酸球の頻度は若青年症例でやや高い傾向が見られたが,両群間に有意の差は見られなかった｡重症例では,老年症例,若青年症例とも,軽症例に比べリンパ球,好中球,好酸球などのBAL細胞の出現頻度が増加しており,特に好酸球では若青年症例の重症例で軽症例に比べ有意に高い頻度が観察された｡これらの結果は, リンパ球,好中球,好酸球などのBAL細胞は,軽症例に比べ重症例で増加してくること,そして,その増加は老年症例では好中球,若青年症例では好酸球の増加が特徴的であることを示唆しているものと考えられた｡ kn-abstract=Cellular composition of bronchoalveolar lavage (BAL) fluid was examined in 11 elderly asthmatics over the age of 70, and the results were compared with those of 11 younger asthmatics under the age of 50. In the subjects with mild asthma, the proportion of BAL cells in the elderly subjects was 86.2% macrophages, 11.0% lymphocytes, 1.9% neutrophils, 0.9% eosinophils and 0.08% basophilic cells. The proportion of neutrophils and eosinophils in the BAL fluid was slightly higher in younger subjects with mild asthma compared with that in elderly subjects, although no significant difference was found between the two groups. In subjects with severe asthma, the proportions of lymphocytes, neutrophils, eosinophils and basophilic cells were more increased in both younger and older patients compared to those with mild asthma, and a significant increase in the number of BAL eosinophils was found in younger subjects with severe asthma compared to those with mild asthma (p < 0.05). However, no significant difference was present in the proportion of BAL cells between younger and older patients with severe asthma. The results reveal that BAL cells are more increased in subjects with suvere asthma than in those with mild asthma in both younger and older subjects, and show the possibility that this increase is more predominant in neutrophils in older subjects and in eosinophils in younger subjects. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=NakagiriYoshiyasu en-aut-sei=Nakagiri en-aut-mei=Yoshiyasu kn-aut-name=中桐善康 kn-aut-sei=中桐 kn-aut-mei=善康 aut-affil-num=9 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=10 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Neutrophils (好中球) kn-keyword=Neutrophils (好中球) en-keyword=Eosinophils (好酸球) kn-keyword=Eosinophils (好酸球) en-keyword=Bronchoalveolar lavage (気管支肺胞洗浄) kn-keyword=Bronchoalveolar lavage (気管支肺胞洗浄) en-keyword=asthma severity (喘息重症度) kn-keyword=asthma severity (喘息重症度) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=34 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Total IgE, IgG and IgG(4) levels in sera of patients with bronchial asthma. Changes of serum concentrations in the elderly en-subtitle= kn-subtitle= en-abstract= kn-abstract=The serum levels of total IgE, IgG and IgG(4) were compared among five age groups of patients with bronchial asthma. 1. The level of serum IgE was significantly higher in the patients before the age of 29 than in those between the ages of 30 and 49 (p < 0.02), between 50 and 59 (p < 0.01) and between 60 and 69 (p < 0.01). The serum IgE level tended to increase in the patients over age 70. 2. The serum level of total IgG was significantly higher in the patients over age 70 compared with the level in the 30-49 (p < 0.05) and the 60-69 year old groups (p < 0.05). 3. The serum IgG(4) level was increased with aging, although no significant difference was found among the five age groups. 4. The IgG(4) level correlated to a certain extent with the level of serum IgE. The results reveal that the levels of total IgE, IgG and IgG(4) are increased in the elderly patients over age 70, and that there is a relationship between serum levels of total IgE and IgG(4). en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=6 ORCID= en-aut-name=HonkeNaoko en-aut-sei=Honke en-aut-mei=Naoko kn-aut-name=本家尚子 kn-aut-sei=本家 kn-aut-mei=尚子 aut-affil-num=7 ORCID= en-aut-name=KusauraYasuhiro en-aut-sei=Kusaura en-aut-mei=Yasuhiro kn-aut-name=草浦康浩 kn-aut-sei=草浦 kn-aut-mei=康浩 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=Total IgE kn-keyword=Total IgE en-keyword=IgG kn-keyword=IgG en-keyword=IgG(4) kn-keyword=IgG(4) en-keyword=aging kn-keyword=aging en-keyword=bronchial asthma kn-keyword=bronchial asthma END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=52 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支肺胞洗浄液中に一過性の好中球増多をきたしたアトピー型喘息 kn-title=Transient bronchoalveolar neutrophilia in a patient with atopic asthma en-subtitle= kn-subtitle= en-abstract=経過中に気管支肺胞洗浄(BAL)液中に一過性の好中球増多が観察されたアトピー型喘息症例について,若干の臨床的観察を加えた｡症例は,64才の女性で,臨床症状,および血清IgE高値,ハウスダストに対するIgE抗体陽性などから,アトピー型喘息と診断された｡なお,経過観察し得た15ヵ月の間に2回の大発作が観察された｡1.第1回の大発作後,BAL液中好中球増多と換気機能の低下が観察された｡そして,このBAL液中好中球頻度は明らかな改善が見られた｡BAL液中の総細胞数および好中球の絶対数も徐々に減少傾向を示し,好中球頻度と同様,第2回目の大発作3ヵ月後には著明な減少が観察された｡同時にこの時期には,BAL液中リンパ球の増加も見られた｡しかし,BAL液中好酸球数は15ヵ月の経過観察中ほとんど変化は見られなかった｡ kn-abstract=Clinical course of one asthma patient (64 years old, female), who had an increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid, was observed in relation to the proportion of BAL cells and ventilatory function. The patient had large asthma attacks two times during her clinical course for 15 months observed. 1. An increased proportion of BAL neutrophils and suppression of ventilatory function were found after her first large asthma attacks. The increased proportion of BAL neutrophils continued for more than 5 months. A reduction in the proportion of BAL neutrophils was found 3 months after her second large asthma attack, accompanied by improvement of clinical symptoms and ventilatory function. The numbers of total cells and neutrophils in BAL fluid were also reduced. Transient increase in number of BAL lymphocytes was found 13 months after the first large attack when the number of BAL neutrophils was markedly decreased. The number of BAL eosinophils did not change during her clinical course. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=NakagiriYoshiyasu en-aut-sei=Nakagiri en-aut-mei=Yoshiyasu kn-aut-name=中桐善康 kn-aut-sei=中桐 kn-aut-mei=善康 aut-affil-num=10 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=11 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) en-keyword=transient BAL neutrophilia(一過性BAL液中好中球増多) kn-keyword=transient BAL neutrophilia(一過性BAL液中好中球増多) en-keyword=ventilatory function (換気機能) kn-keyword=ventilatory function (換気機能) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=60 end-page=64. dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of the spring water on the dissolution of aminophylline tablet and theophylline sustained-release preparations kn-title=薬物の溶出に及ぼす温泉水の影響(第1報)　―アミノフィリン製剤およびテオフィリン徐放製剤について― en-subtitle= kn-subtitle= en-abstract=The dissolutions of aminophylline tablet and theophylline sustained-release preparattions in Misasa spring water were examined using the rotating basket and paddle methods. The dissolution rate of aminophylline tablet with the spring water was higher than that with distilled water from starting to 10 min after the test. In theophylline sustained-release preparations, the spring water showed a facilitation on the dissolution rate in comparison to the distilled water for 8 hours after the test. These results indicate that the spring water enhanced the releasing rates of aminophylline tablet and theophylline sustained-release preparations. kn-abstract=薬物のbioavailabilityに影響する因子の一つとして,製剤からの薬物の溶出速度が考えられる｡今回,温泉水による薬物溶出への影響を知る目的で,気管支喘息治療薬のアミノフィリン製剤およびテオフィリン徐放製剤の溶出挙動について検討した｡溶出試験は第12改正日本薬局方に従い,第1法(回転バスケット法)および第2法(パドル法)で行い,試験液を蒸留水および三朝温泉水として両者の溶出挙動を比較した｡アミノフィリン製剤では,10分後まで 温泉水の方が有意に高い溶出率を示した｡また,テオフィリン徐放製剤においても温泉水が8時間後まで蒸留水に比べて有意に高い溶出率を示した｡以上の結果より,アミノフィリン製剤およびテオフィリン徐放製剤は温泉水により薬物の溶出が促進されることか示唆された。 en-copyright= kn-copyright= en-aut-name=MimakiYuichi en-aut-sei=Mimaki en-aut-mei=Yuichi kn-aut-name=三牧祐一 kn-aut-sei=三牧 kn-aut-mei=祐一 aut-affil-num=1 ORCID= en-aut-name=FujiiYoshihiro en-aut-sei=Fujii en-aut-mei=Yoshihiro kn-aut-name=藤井義博 kn-aut-sei=藤井 kn-aut-mei=義博 aut-affil-num=2 ORCID= en-aut-name=FurunoKatsushi en-aut-sei=Furuno en-aut-mei=Katsushi kn-aut-name=古野勝志 kn-aut-sei=古野 kn-aut-mei=勝志 aut-affil-num=3 ORCID= en-aut-name=GomitaYutaka en-aut-sei=Gomita en-aut-mei=Yutaka kn-aut-name=五味田裕 kn-aut-sei=五味田 kn-aut-mei=裕 aut-affil-num=4 ORCID= en-aut-name=ArakiYasunori en-aut-sei=Araki en-aut-mei=Yasunori kn-aut-name=荒木泰典 kn-aut-sei=荒木 kn-aut-mei=泰典 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院薬剤室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院薬剤室 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院薬剤部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院薬剤部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院薬剤部 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=溶出試験 (Dissolutionte test) kn-keyword=溶出試験 (Dissolutionte test) en-keyword=温泉水 (Spring water) kn-keyword=温泉水 (Spring water) en-keyword=気管支喘息治療薬 (Bronchial asthma therapeutic drug) kn-keyword=気管支喘息治療薬 (Bronchial asthma therapeutic drug) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=39 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=老年者の気管支喘息. アレルギー反応と気道細胞反応 kn-title=Bronchial asthma in the elderly. Relationship to allergic reaction and airway inflammation en-subtitle= kn-subtitle= en-abstract=70才以上の老年者気管支喘息の特徴について,アレルゲンに対する即時型皮膚反応および特異的IgE抗体,換気機能,気管支肺胞洗浄液(BAL)中の細胞成分などにより検討した｡1.アレルゲンに対する即時型皮膚反応および特異的IgE抗体の陽性率は,全般的にかなり低い傾向を示した｡2.換気機能にはかなりのばらつきが見られたが,25例中15例(60%)では,,いずれの換気パラメー ターもかなり高い値を示し,これらの症例の平均FEV(1.0%)は71.3%であった｡3.BALを施行した11例中,% V(25)値の低下とBAL中好中球増多との間に関連の見られた症例は2例のみで,他の9例では% Ⅴ(25)値の高度な低下にもかかわらず,BAL中の好中球増多は見られなかった｡これらの結果より,老年者気管支喘息では,IgEにmediateされるアレルギー反応は全般的に弱いこと,またBAL液中好中球増多なしに% V(25)値の高度な低下が出現してくることが示された｡ kn-abstract=Clinical features of bronchial asthma in the elderly were analyzed by observlng IgE-mediated allerglc reactions evaluated by immediate skin reaction and specific IgE antibodies to allergens, ventilatory function and cellular composition in bronchoalveolar lavage (BAL) fluid. 1. The frequency of positive immediate skin reaction and positive RAST score to allergens was in general low in the elderly patients over age 70. 2. Ventilatory function was widely variegated, and fifteen cases (60%) of the 25 Subjects showed considerably high values of FEV(l.0%), % PEFR, % MMF, % V(50) and % V(25), and the mean value of FEV(1.0%) in these cases was 71.3%. 3. The decreased value of % V(25) was related to BAL neutrophilia in 2 cases, but any correlation was not found between BAL neutrophilia and decreased value of % V(25) in 9 csese of the eleven subjects who had the BAL examination. The results show that in asthma of elderly patients, IgE-mediated allergic reactions are weak, and that a decreased value of % V(25) can be observed without BAL neutrophilia. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=6 ORCID= en-aut-name=HonkeNaoko en-aut-sei=Honke en-aut-mei=Naoko kn-aut-name=本家尚子 kn-aut-sei=本家 kn-aut-mei=尚子 aut-affil-num=7 ORCID= en-aut-name=KusauraYasuhiro en-aut-sei=Kusaura en-aut-mei=Yasuhiro kn-aut-name=草浦康浩 kn-aut-sei=草浦 kn-aut-mei=康浩 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=10 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=elderly subjects (老年者) kn-keyword=elderly subjects (老年者) en-keyword=lgE-mediated allergic reaction (IgE系反応) kn-keyword=lgE-mediated allergic reaction (IgE系反応) en-keyword=ventilatory function (換気機能) kn-keyword=ventilatory function (換気機能) en-keyword=BAL neutrophilia (BAL好中球) kn-keyword=BAL neutrophilia (BAL好中球) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=65 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagonosis of pancreatic cyst using post-ERCP CT examination. kn-title=ERCP後CTによる膵嚢胞性疾患の診断 en-subtitle= kn-subtitle= en-abstract=Post-ERCP CT (computed tomography (CT) examination performed immediately after endoscopic retrograde cholangiopancreatography) detects the contrast medium injected into the pancreatic duct and cystic lesions at the time of ERCP and, therefore, has the advantage of obtaining information which cannot be obtained by ERCP alone. We have experienced four cases of pancreatic cysts in which post-ERCP CT was useful for diagnosis and in deciding on treatment plans. The post-ERCP CT was proved to be a useful method for examining the site and characteristics of the cysts which communicated with the main pancreatic duct. kn-abstract=ERCP直後にCTを撮影するERCP後CTはERCPの際に膵内に注入された造影剤をCTで検出するため,ERCPでは得られない情報が得られる利点がある｡われわれはERCP後CTが診断や治療方針の決定に有用であった膵嚢胞の4例を経験した｡膵嚢胞では主膵管との連絡,嚢胞の部位,性状診断にERCP後CTは有用な検査法であり,文献的考察を含めて報告した｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoTosinobu en-aut-sei=Seno en-aut-mei=Tosinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=RiazChowdhury kn-aut-sei=Riaz kn-aut-mei=Chowdhury aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=8 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=11 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=12 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学第2内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院 affil-num=9 en-affil= kn-affil=岡山大学三朝分院 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=岡山大学三朝分院 affil-num=13 en-affil= kn-affil=勝山病院外科 en-keyword=ERCP (Endoscopic retrograde cholangiopancreatography) kn-keyword=ERCP (Endoscopic retrograde cholangiopancreatography) en-keyword=CT (Computed tomography) kn-keyword=CT (Computed tomography) en-keyword=膵嚢胞 (pancreatic cyst) kn-keyword=膵嚢胞 (pancreatic cyst) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=44 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=老令者の気管支喘息,各臨床病型における換気機能の特徴 kn-title=Bronchial asthma in the elderly. Ventilatory function in each clinical asthma type. en-subtitle= kn-subtitle= en-abstract=60才以上の老年気管支喘息20例(平均年令;66.7才)を対象に,その換気機能について,臨床病態別に59才以下の症例(平均年令;44.9才)との比較検討を行った｡1.FFV(1.0%), % PEFR, % MMF, % V50, % V25などの閉塞性換気障害を表すパラメーターは,59才以下の症例に比べ老年症例で全般的に低い傾向が見られた｡2.小ないし細気管支領域の換気榛能を反映すると考えられる% V(50)および% V(25)は,Ib型およびII型喘息を示す老年症例において,59才以下の症例に比べ,有意に低い値を示した｡3.II型喘息症例では,59才以下および老年症例のいずれにおいても, %　MMF, % V(50)および% V(25)は他の臨床病型にくらべ著明に低い値を示した｡これらの結果は,気管支喘息における換気機能は,加令とともに低下傾向を示すこと,そしてその低下は臨床病態と関連していることを示しているものと考えられた｡ kn-abstract=Ventilatory function was examined in 20 elderly patients with bronchial asthma in relation to clinical asthma types, and the results were compared with those of younger asthmatics. 1. Ventilatory parameters such as FEV(1.0%), % PEFR, % MMF, % V(50) and % V(25), which repressent obstructive ventilatory dysfunction, were in general lower in older asthmatics than in the youger cases. 2. The values of % V(50) and % V(25), representing ventilatory dysfunction in small airways, were significantly lower in the older subjects with type Ib and II compared to the younger cases with same types. 3. Markedly decreased values in ventilatory parameters, particularly in % MMF, % V(50) and　% V(25) were observed in both older and younger subjects with type II. The results suggest that ventilatory function decreases with aging and the decrease is related to the pathophysiological changes in the airways. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=6 ORCID= en-aut-name=HonkeNaoko en-aut-sei=Honke en-aut-mei=Naoko kn-aut-name=本家尚子 kn-aut-sei=本家 kn-aut-mei=尚子 aut-affil-num=7 ORCID= en-aut-name=KusauraYasuhiro en-aut-sei=Kusaura en-aut-mei=Yasuhiro kn-aut-name=草浦康浩 kn-aut-sei=草浦 kn-aut-mei=康浩 aut-affil-num=8 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=9 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=10 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=10 en-affil= kn-affil=岡山大学医学部付属病院三朝分院産婦人科 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=Ventilatory function (換気機能) kn-keyword=Ventilatory function (換気機能) en-keyword=small airways (細気管支) kn-keyword=small airways (細気管支) en-keyword=clinical asthma types (臨床病型) kn-keyword=clinical asthma types (臨床病型) en-keyword=elderly　asthmatics (老年者気管支喘息) kn-keyword=elderly　asthmatics (老年者気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=71 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of vitamin D and exercise on bone mineral density (BMD) measuured by QCT kn-title=QCTによる骨塩量測定とその経時的変化による骨粗鬆症の治療効果判定 en-subtitle= kn-subtitle= en-abstract=Bone mineral density (BMD) was measured twice in 38 patients aged 40 to 84 years old for the last one year to evalute the effects of vitamin D and exercise on BMD. 1) In all patients, The BMD did not significantly increase. 2) In patients with vitamin D for osteoprosis, the BMD did not significantly increse compared to those without the drug. 3) In patients with exercise therapy, the BMD did not show any significant increase compared to those without exercise. kn-abstract=40才～84才(平均64.1才)の患者38例における骨塩量を,ある期間(1～15カ月,平均8.2カ月)をおいて2回,定量的QCT(quantitative computed tomography)法を用いて測定し,その経時的変化によって,骨粗鬆症に対する治療法の効果判定を試みた｡その結果,(1)全体として骨塩量に有意の増加は認められなかった｡(2)骨強化剤使用例についても骨塩量に有意の増加は認められなかった｡(3)運動療法施行者においても骨塩量に有意の増加は認められなかった｡以上のことから骨粗鬆症の治療においては,約1年弱の経過では著明な反応は得られにくいものと思われた｡ただし,一部の運動療法施行者,骨強化剤使用者において,骨塩量の著明な上昇が認められており,さらに経時的な観察が必要と思われた。 en-copyright= kn-copyright= en-aut-name=HiramatsuJunnichi en-aut-sei=Hiramatsu en-aut-mei=Junnichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=1 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦家正志 kn-aut-sei=瓦家 kn-aut-mei=正志 aut-affil-num=2 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=3 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=6 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=7 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=NakaiMutsuro en-aut-sei=Nakai en-aut-mei=Mutsuro kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=10 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 en-keyword=骨粗鬆症 (Osteoprosis) kn-keyword=骨粗鬆症 (Osteoprosis) en-keyword=定量的QCT法 (QCT) kn-keyword=定量的QCT法 (QCT) en-keyword=加齢 (Aging) kn-keyword=加齢 (Aging) en-keyword=運動療法 (Exercise) kn-keyword=運動療法 (Exercise) en-keyword=ビタミンD (Vitamin D) kn-keyword=ビタミンD (Vitamin D) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=89 end-page=96 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における気道の反応性および炎症反応におよぼす加齢の影響について kn-title=Effects of aging on responsiveness and inflammation in the airways of patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=25例の老年者気管支喘息と25例の若壮年者喘息症例を対象に,換気機能,気道内細胞成分の頻度,白血球からの化学伝達物質遊離などの気道反応と関連した要素について,喘息の臨床病型との関連のもとに検討を加えた｡ 1. % MMF, % V(50), % V(25)などの換気パラメーターは老年症例において全般的に低く, % V(50)では若壮年症例に比べ有意の低値を示した｡臨床病型別では,II型喘息において,両年齢群とも他の病型に比べ% MMF, % V(50)及び% V(25)値は有意に低い傾向が見られた｡ 2. 気管支肺胞洗浄(BAL)液中のリンパ球頻度は,II型の老年症例において若壮年症例に比べ有意に低い値を示した｡BAL液中好中球頻度は,いずれの年齢群においても,他の病型に比べ有意に高い値を示した｡ 3. 白血球からのLTC(4)遊離は,II型の老年症例において若壮年症例に比べ,また他の臨床病型に比べ有意に低い値を示した｡ヒスタミンおよびLTB(4)遊離には両年歯群間に有意の差は見られなかった｡これらの結果は,換気機能,気道内細胞成分の頻度,白血球からの化学伝達物質遊離などが,加齢や臨床病態により影響を受けることをある程度示しているものと考えられた｡ kn-abstract=Ventilatory function, cellular composition in bronchoalveolar lavage (BAL) fluid and release of chemical mediators from leucocytes were examined in 25 older asthmatics (mean age 66.7 years) and 25 younger asthmatics (mean age 45.1 years) in relation to clinical asthma types. 1. Ventilatory function tests showed that the values of ventilatory parameters such as % MMF, % V(50) and % V(25) were lower in older subjects than in younger subjects, and a significant difference was found in the % V(50) value between the two age groups. Regarding clinical asthma types, the values of % MMF, % V(50), and V(25) were significantly lower in both younger and older subjects with type II. 2. In analysis of cellular composition in BAL fluid, the proportion of BAL lymphocytes was significantly lower in type II older subjects than in younger subjects with the same type. A significantly increased proportion of BAL neutrophils was observed in both younger and older subjects with type II. 3. The release of leukotriene C(4) (LTC(4)) from leucocytes was significantly lower in type II older subjects than in younger subjects with the same type, and LTC(4) release in patients with type II was also significantly lower than that in those with other asthma types in both younger and older subjects. The release of histamine and leukotriene B(4) (LTB(4)) from leucocytes was not significantly different between the two age groups. These results demonstrate that ventilatory function, cellular composition in BAL fluid, and the release of chemical mediators from leucocytes are affected by aging and clinical asthma types. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Ventilatory function (換気機能) kn-keyword=Ventilatory function (換気機能) en-keyword=Cellular composition in BAL fluid (気道内細胞成分) kn-keyword=Cellular composition in BAL fluid (気道内細胞成分) en-keyword=chemical mediators (化学伝達物質) kn-keyword=chemical mediators (化学伝達物質) en-keyword=aging (加齢) kn-keyword=aging (加齢) en-keyword=clinical asthma type (臨床病型) kn-keyword=clinical asthma type (臨床病型) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=50 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IgE受容体を介する刺激に対する好塩基球の形態的変化の顕微鏡的観察. 抗原と抗IgE刺激の特徴とその相違点 kn-title=Microscopic observation on morphological changes of basophils induced by cross-linking of IgE receptors en-subtitle= kn-subtitle= en-abstract=抗原および抗IgE刺激時の好塩基球の形態変化の特徴について,ヒスタミン遊離との関連のもとに,顕微鏡下に経時的に観察した｡1.抗原刺激時のヒスタミン遊離は,15分間のincubationのいずれの時期においても,抗IgE刺激に比べ有意に多く,incubation時間3分と9分では両者間に有意の差が見られた｡2.抗原刺激時の好塩基球数の減少も抗IgE刺激に比べより高度であった｡3.運動亢進により洋梨型を示す抗塩基球では,長径/短径比の増大が見られた｡この長径/短径比の増大を示す好塩基球は,抗原刺激時に抗IgE刺激に比べより高頻度に見られ,特にincubation6分と15分では両者間に有意の差が見られた｡4.膨化型を示す好塩基球ではその平均直径の増大が見られるが,この平均直径の増大については,抗原と抗lgE刺激との間に差は見られなかった｡以上の結果より,抗原刺激では,好塩基球のactivate,運動亢進へ の過程が抗IgE刺激時と比べより高度であるが,膨化への過程には両者間に差が見られないことが示唆された｡ kn-abstract=Differences in morphological changes of basophils between antigen and anti-IgE　stimulation were examined in atopic subjects in relation to histamine release.　1. Antigen-　induced release of histamine was remarkably more rapid and larger at any incubation time than the release by anit-IgE, and a significant difference was found at 3 to 9 min. 2. Decrease in number of basophils induced by antigen was significantly higher for 12 to 15 min incubation time than that by anti-IgE. 3. Morphological changes of basophils representing increased motility such as an increased ratio of short to long axis diameter (L/S ratio) and an increased incidence of basophils with localized granules (LG) were more often observed in antigen stimulation compared with anti-IgE, and the L/S ratio of the cells was significantly more increased in antigen stimulation at 6 and 15 min. 4. There was no difference in morphological changes of basophils showimg swollen type (degranulation) such as an increased mean diameter (MD) of the cells between antigen and anti-IgE. These results suggest that antigen activates basophils and induces increased motility more strongly than anti-IgE, but the action on degranulation was not different between the two agents. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川三郎 kn-aut-sei=中川 kn-aut-mei=三郎 aut-affil-num=2 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=3 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=Histamine release (ヒスタミン遊離) kn-keyword=Histamine release (ヒスタミン遊離) en-keyword=Morphological changes of basophils (好塩基球の形態的変化) kn-keyword=Morphological changes of basophils (好塩基球の形態的変化) en-keyword=Antigen (抗原) kn-keyword=Antigen (抗原) en-keyword=Anti-IgE (抗IgE) kn-keyword=Anti-IgE (抗IgE) en-keyword=IgE receptors (IgE受容体) kn-keyword=IgE receptors (IgE受容体) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=58 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=高齢者健常人および気管支喘息患者におけるカンジダ特異的IgGおよびIgG(4)抗体について kn-title=Difference in specific IgG and IgG(4) antibodies against Candida aibicans between healthy and asthmatic subjects in the elderly en-subtitle= kn-subtitle= en-abstract=高齢者(61才以上)の健常人48名および気管支喘息患者69例を対象に,カンジダ特異的IgGおよびIgG(4)抗体を測定し,その増加の機序について若干の検討を加えた｡なお,対照としては,30才以下の健常者および気管支喘息患者を選んだ。1.カンジダ特異的IgGおよびIgG(4)抗体価は,30才以下では,健常人に比べ気管支喘息症例で高い傾向が見られ,特異的IgG抗体では両者間に有意の差が見られた(p<0.05)。2.カンジダ特異的IgGおよびIgG(4)抗体は,健常人および気管支喘息症例いずれも加齢とともに増加する傾向が見られ,71才では,30才以下の症例に比べ有意に高い抗体価を示した｡3.61才以上の高齢者では,特異的IgG,IgG(4)抗体いずれにおいても,健常人と気管支喘息患者との間に有意の差は見られなかった。 kn-abstract=Specific IgG and IgG(4) antibodies against Canadida albicans were exmined in 48 healthy and 69 asthmatic subjects to analyze the mechanism causing an increased production of these immunoglobulins. 1. The level of C.albicans-specific IgG and IgG(4) antibodies was higher, not significantly in IgG(4), in asthmatics under 30 years of age, compared with healthy subjects of the same age group. 2. Specific IgG and IgG(4) antibody levels in both healthy and asthmatic subjects showed a tendency to increase with aging, and significant difference was present between cases under 30 years and cases over 70 years of age. 3. Any difference in the production of specific IgG and IgG(4) was not observed in elderly cases older than 60 years between healthy and asthmatic subjects. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=KotohNaoki en-aut-sei=Kotoh en-aut-mei=Naoki kn-aut-name=古藤直樹 kn-aut-sei=古藤 kn-aut-mei=直樹 aut-affil-num=6 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Candida albicans (カンジダ特異的IgG) kn-keyword=Candida albicans (カンジダ特異的IgG) en-keyword=Specific IgG kn-keyword=Specific IgG en-keyword=IgG(4) kn-keyword=IgG(4) en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) en-keyword=Aging (加齢) kn-keyword=Aging (加齢) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=63 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=臨床所見および検査成績からのスコアーによる喘息分類の特徴 kn-title=Characteristics of asthma classified by a score relating to clinical findings and examinations en-subtitle= kn-subtitle= en-abstract=気管支喘息36例を対象に,臨床病態による喘息の分類（臨床診断）を試み,この分類と臨床所見および臨床検査より求めたスコアーによる分類（スコアー分類）との比較検討を行った｡1.臨床分類でIa.単純性気管支攣縮型と診断された12症例のうち,1日喀痰量0-49mlの8症例は,スコアー分類では同様にIa.型と分類された｡一方,1日喀痰量50-99mlの4症例はスコアー分類ではIb.型（気管支攣縮+過分泌型）と分類された｡これら4症例のBALF中好酸球増多はIb.型に類似した病態であった｡2.臨床診断によりIb.型に分類された6症例はいずれもスコアー診断でもIb.型と分類された｡3.臨床診断によりII.型（細気管支閉塞型）と分類された8症例のうち,7症例はスコアー診断でもII.型と分類されたが,1症例はスコアー10でII.型の診断基準に合わず,questionable II.型と診断された｡ kn-abstract=Twenty six patients with bronchial asthma was classified by clinical symptoms and singns (clinical diagnosis), and the classification by clinical diagnosis was compared with the classification by a score calculated from clinical findings and examinations (score diagnosis). 1. Of 12 subjects with type Ia classified by clinical diagnosis, 8 cases with 0 to 49 ml/day of expectoration were evaluated as type Ia by score diagnosis. While four type Ia cases with 50 to 99ml/day of expectoration were calssified as type Ib by score diagnosis. The increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF) of these four cases was similar to the incidence in type Ib cases with hypersecretion. 2. All of 6 subjects with type Ib by clinical diagnosis were estimated as type Ib by score diagnosis. 3. Of 8 cases with type II by clinical diagnosis, 7 cases were assessed as type II by score diagnosis. One case with type II by clinical diagnosis and with the score of 10 points was evaluated as questionable type II by score diagnosis. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=6 ORCID= en-aut-name=HonkeNaoko en-aut-sei=Honke en-aut-mei=Naoko kn-aut-name=本家尚子 kn-aut-sei=本家 kn-aut-mei=尚子 aut-affil-num=7 ORCID= en-aut-name=KusauraYasuhiro en-aut-sei=Kusaura en-aut-mei=Yasuhiro kn-aut-name=草浦康浩 kn-aut-sei=草浦 kn-aut-mei=康浩 aut-affil-num=8 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=9 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=10 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=asthma classification (喘息分類) kn-keyword=asthma classification (喘息分類) en-keyword=bronchoconstriction (気管支攣縮) kn-keyword=bronchoconstriction (気管支攣縮) en-keyword=hypersecretion (過分泌) kn-keyword=hypersecretion (過分泌) en-keyword=bronchiolar obstruction (細気管支閉塞) kn-keyword=bronchiolar obstruction (細気管支閉塞) en-keyword=score diagnosis (スコアー診断) kn-keyword=score diagnosis (スコアー診断) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=69 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者における細胞性免疫,ガンジダ抗原に対する遅延型反応の抑制 kn-title=Cell-mediated immunity in bronchial asthma. Depressed response towards Candida albicans en-subtitle= kn-subtitle= en-abstract=気管支喘息200例を対象にカンジダに対する即時型および遅延型皮膚反応を観察し,これらの皮膚反応と年令,血清IgE値との関連について検討を加えた｡1. カンジダに対する遅延型皮膚反応は,10～20才の年齢層および61才以上の年齢層の症例において,その陽性率の低下が観察された｡そして,10～20才の年齢層と41～50才の年齢層の症例では,両者間で陽性率の有意の差が見られた(p<0.001)。2. カンジダに対する遅延型皮膚反応の陽性率は,血清IgE値が低い(0～100 IU/ml)症例において最も高く,一方血清IgE値が高い(1001IU/ml以上)症例において最も低いという傾向が見られた｡これらの結果は,カンジダに対する細胞性免疫は,10～20才の年齢層ではアトピーと,また61才以上の年齢層では加齢と関連して抑制されることを示唆するものと考えられる。 kn-abstract=Delayed cutaneous hypersensitivity towards Candida albicans was examined　in 200 patients with bronchial asthma in relation to patient age and the level of　total IgE. 1. Delayed skin reactivity towards C.albicans was depressed in the patients between the ages of 10 and 20 and in those over the age of 61. A significant difference was present in delayed skin reactivity between the groups of 10-20 and 41-50 years old. 2. The frequency of the patients with positive delayed skin reactivity towards C.albicans was the highest in those with low levels of total IgE (0 -100 IU/ml) and the low est in those with high levels of total IgE (over than 1001 IU/ml). The results suggest that cell-mediated immunity towards C.albicans is depressed re lating to atopics in the patients between 10 and 20 and to aging in the patients over 61. en-copyright= kn-copyright= en-aut-name=TanizakiYosiro en-aut-sei=Tanizaki en-aut-mei=Yosiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=cell-mediated immunity (細胞性免疫) kn-keyword=cell-mediated immunity (細胞性免疫) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=atopics (アトピー) kn-keyword=atopics (アトピー) en-keyword=aging (加齢) kn-keyword=aging (加齢) en-keyword=カンジダ kn-keyword=カンジダ END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=74 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical evaluation of an endoscopic image filing system, Olympus SDF-3 kn-title=電子内視鏡ファイリングシステムSDF-3の使用経験 en-subtitle= kn-subtitle= en-abstract=Olympus SDF-3, an endoscopic image　filing system using an electronic endoscope in　conjunction with a personal computer and an　optical disk, has been recently developed. We evaluated the usefulness of this filing system with 449 cases of gastroduodenal endoscopy. As a result, we have found that this filing system has following advantages : (1) one can review endoscopic images immediately after endoscopic examinations ; (2) previously documented endoscopic image can be searched and reviewed in a short time ; (3) statistical analysis of documented cases is facilitated. However, it has some disadvantages as well to be improved : (1) quality of endoscopic images is deteriorated in the process of filing ; (2) putting patients' data into the filing system is time-consuming ; (3) frequent cleaning of an optic disk is required. This endoscopic image filing system needs to be further developed and refined. kn-abstract=光ディスクとパーソナルコンピュータを組み合わせた内視鏡画像ファイリングシステムは電子内視鏡の画像の保存･管理,検索･再生などに威力を発揮する｡今回,われわれはオリンパス社製内視鏡ファイリングシステムSDF-3を使用する機会を得たので,その有用性や問題点の検討を行った｡有用性としては,①内視鏡画像を検査終了後直ちに再生し,再検討できる,②多数の項目についての検索や統計処理が可能である,③限られたスペース内で大量の画像データの一括保存･管理が可能であるなどが挙げられる｡一方,問題点としては,①内視鏡再生画像は画質が劣化する,②検索機能を十分に活用するにはかなり煩雑な人力操作を必要とする,③光ディスクの清掃が必要であるなどがあげられる｡本内視鏡ファイリングシステムに今後必要な改良点やその展望についても合わせて考案を加えた。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=TanizakiYosiro en-aut-sei=Tanizaki en-aut-mei=Yosiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=画像ファイリングシステム (image filing system) kn-keyword=画像ファイリングシステム (image filing system) en-keyword=電子内視鏡 (electronic endoscope) kn-keyword=電子内視鏡 (electronic endoscope) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=95 end-page=98 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Inhibitory effect of furosemide on histamine release from human basophils kn-title=furosemide添加による末梢血好塩基球からのヒスタミン遊離抑制作用について en-subtitle= kn-subtitle= en-abstract=Inhibitory effect of furosemide on histamine release from basophils induced by anti-IgE was examined in 4 healthy subjects and 8 patients with atopic asthma. The experiments of basophil histamine release were carried out by using whole blood method. The mean values of histamine release after 15 min preincubation with furosemide at various concentrations were not significantly decreased, in both healthy and asthmatic subjects compared to those of histamine release without furosemide. The results obtained here show that furosemide does not inhibit histamine release from basophils by the whole blood method. kn-abstract=furosemideは利尿剤として知られているが,吸入することにより気道収縮に対して抑制的に作用することが近年報告されている｡その抑制作用の機序を明らかにする目的で,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果を検討した｡健常人4例,アトピー型気管支喘息患者8例を対象として全血法で抗ヒトIgE刺激によるヒスタミン遊離を観察した｡なお,furosemideの最終濃度は0,1,10,100μg/mlに調整して添加実験を行った｡健常人,気管支喘息いずれにおいても,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果はみられなかった｡ en-copyright= kn-copyright= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=1 ORCID= en-aut-name=KusauraYasuhiro en-aut-sei=Kusaura en-aut-mei=Yasuhiro kn-aut-name=草浦康浩 kn-aut-sei=草浦 kn-aut-mei=康浩 aut-affil-num=2 ORCID= en-aut-name=HonkeNaoko en-aut-sei=Honke en-aut-mei=Naoko kn-aut-name=本家尚子 kn-aut-sei=本家 kn-aut-mei=尚子 aut-affil-num=3 ORCID= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=6 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=フロセミド (Furosemide) kn-keyword=フロセミド (Furosemide) en-keyword=ヒスタミン遊離 (Histamine release) kn-keyword=ヒスタミン遊離 (Histamine release) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=99 end-page=105 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relationship between bone mineral densities　of second metacarpal bone and lumber spine kn-title=手指骨骨塩量と腰椎骨塩量の相関性と診断への応用 en-subtitle= kn-subtitle= en-abstract=To compare bone mineral density between second metacarpal bone and lumber spine,　two measuring methods, digital image processing　method (DIP) for second metacarpal bone and quantitative computed tomography (QCT) for lumber spine were employed in this study. The bone mineral density was evaluated in 89 females and the results were compared between the two methods. A correlation between the bone mineral densities by QCT and ΣGS/D was found in subjects showing low mineral density by QCT, but not in those with high mineral density. These results reveal that DIP is useful to observe bone mineral density and if ΣGS/D and MCI are enough high, almost he hasn't risk of fracture of lumber spine. kn-abstract=QCTおよびDIP法による測定値の相関性について検討し,DIP法による腰椎骨塩量の推定および,スクリーニングへの適用について考察した｡QCT値とΣGS/DやMClとの相関関係の検討では.対象のQCT値が低値か高値かによって相関関係がかなり異なることが明らかになった｡すなわち,QCT値が低い領域は,QCT値と,ΣGS/DやMCIに明らかな正の相関関係が認められたが,一方, QCT値が高い領域では,相関関係は認められなかった｡また,ΣGS/D=2.8mmAI以上,またはMCI=0.48以上の症例においては腰椎圧迫骨折の危険は小さく,ΣGS/D=1.8mmAI以下,またはMCI=0.24以下の症例においては腰椎圧迫骨折の危険が大きい可能性が示唆された。 en-copyright= kn-copyright= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=1 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=2 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=3 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=骨粗鬆症 (osteoporosis) kn-keyword=骨粗鬆症 (osteoporosis) en-keyword=骨塩量 (bone mineral density) kn-keyword=骨塩量 (bone mineral density) en-keyword=QCT (quantitative computed tomography) kn-keyword=QCT (quantitative computed tomography) en-keyword=DIP法 (digital image processing method) kn-keyword=DIP法 (digital image processing method) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=79 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Character, Habit and Taste of woman with coldeness in their bodies kn-title=冷え性婦人の病態生理学的検討―第3報,冷え性婦人の性格･生活習慣･食事の嗜好調査― en-subtitle= kn-subtitle= en-abstract=The character, habit and taste were studied about by means of a questionnaire survey and Cornell Medical Index in 100 women who felt cold in their part of bodies. More than 30% of the women showed the neurotic personality, They had a tendency to dislike the greasy foods, and frequently had sweet foods. More than 50% of them ordinally complained of shoulder stiffness and generalfatigue. The women who played sports weekly were less than 20%. The neurotic porsonality, the tendency to dislike the greasy foods and the lack of exercise were seemed to be the feature of their character, taste, and habit. Thus, improvement of their personality and life style may have a good effect on the coldness in women. kn-abstract=冷え性の発現は寒冷刺激に対する血管運動性体温調節と密接に関係しているが,患者の性格･生活習慣･食事の嗜好等にも関わっていると考えられる｡そこで今回は冷え性婦人100名を対象にCMl調査と35項目にのぼるアンケート調査を行った｡その結果,冷え性の増悪因子として,日頃の運動不足･神経症的性格傾向･過労･食べ物の嗜好がクローズアップされ,この面での生活指導が冷え性の治療を行っていく上で,薬物的な治療と並んで重要であることか示唆された。 en-copyright= kn-copyright= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=1 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=2 ORCID= en-aut-name=SakataJunko en-aut-sei=Sakata en-aut-mei=Junko kn-aut-name=坂田旬子 kn-aut-sei=坂田 kn-aut-mei=旬子 aut-affil-num=3 ORCID= en-aut-name=FujiiJunko en-aut-sei=Fujii en-aut-mei=Junko kn-aut-name=藤井純子 kn-aut-sei=藤井 kn-aut-mei=純子 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=冷え性 (Coldness in women) kn-keyword=冷え性 (Coldness in women) en-keyword=性格 (Character) kn-keyword=性格 (Character) en-keyword=生活習慣 (Habit) kn-keyword=生活習慣 (Habit) en-keyword=嗜好 (Taste) kn-keyword=嗜好 (Taste) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=85 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The efficacy of maternity swimming to reduce　mother's weight kn-title=岡山大学医学部附属病院三朝分院における妊婦水泳 ―第５報　妊婦水泳による体重減少効果について― en-subtitle= kn-subtitle= en-abstract=The efficacy of awimming to reduce mother's weight were studided retrospectively in 107 women. Each time they swum for a hour. They were given a chance of swimming at only one time in a week. Most of them reduced their weight after the swimming. The average of the weight loss was 460 gram after each time of swimming. In women who had a chance of swimming at ten times or more, the mother's weight gain in a week when they had a chance of swimming, was statistically (p<0.01) less than the weight in a week when they didn't swim. Thus, the maternity swimming was thought to have the efficacy to reduce mother's weight. If the maternlty swimming is clinically applied for the treatment of obese pregnant women, their weight will reduce efficiently. kn-abstract=第1報において妊婦水泳に関する妊婦の認識について報告し (1) ,第2報において妊婦水泳の現状とその適応について報告した (2) ｡その後,第3報において妊婦水泳が母児の循環系におぼす影響について報告し (3) ,第4報にて出産後1年間の児の予後調査を行った (4) 。今回は,妊婦水泳による体重減少効果について検討を行った。その結果,妊婦水泳前後で平均460gの体重減少がみられた｡また水泳を10回以上行った妊婦において,水泳を行っている期間の体重増加が水泳を行っていない期間の体重増加に比べて有意に少なかった｡これより,妊婦水泳には一定の減量効果があり,肥満妊婦の治療にも応用できると考えられた。 en-copyright= kn-copyright= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=1 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=2 ORCID= en-aut-name=SakataJunko en-aut-sei=Sakata en-aut-mei=Junko kn-aut-name=坂田旬子 kn-aut-sei=坂田 kn-aut-mei=旬子 aut-affil-num=3 ORCID= en-aut-name=KamimotoManabu en-aut-sei=Kamimoto en-aut-mei=Manabu kn-aut-name=上本学 kn-aut-sei=上本 kn-aut-mei=学 aut-affil-num=4 ORCID= en-aut-name=FujiiJunko en-aut-sei=Fujii en-aut-mei=Junko kn-aut-name=藤井純子 kn-aut-sei=藤井 kn-aut-mei=純子 aut-affil-num=5 ORCID= en-aut-name=DokaiChiho en-aut-sei=Dokai en-aut-mei=Chiho kn-aut-name=土海智穂 kn-aut-sei=土海 kn-aut-mei=智穂 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院リハビリテーション部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=妊婦水泳 (Maternity Swimming) kn-keyword=妊婦水泳 (Maternity Swimming) en-keyword=体重減少 (Reduce mother's weight) kn-keyword=体重減少 (Reduce mother's weight) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=89 end-page=94 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ラット腹腔肥満細胞のCa(2+) influxおよびヒスタミン遊離に対する抗アレルギー薬アゼラスチンの抑制効果について kn-title=Antiallergic agent, azelastine, inhibits (45)Ca uptake and histamine release in rat mast cells stimulated by antigen en-subtitle= kn-subtitle= en-abstract=抗原刺激時の,ラット腹腔肥満細胞のCa(2+) uptakeおよびヒスタミン遊離に対する,抗アレルギー薬アゼラスチンの抑制効果について検討を加えた｡その結果,1.アゼラスチンは抗原刺激時の肥満細胞のCa(2+) uptakeに対して濃度依存性の抑制効果を示した｡2.同様に,抗原刺激時の肥満細胞からのヒスタミン遊離に対しても,濃度依存性の抑制効果を示した｡3.アゼラスチンの再暴露による抑制効果の減弱傾向は見られず,アゼラスチンでは　tachyphylaxisは観察されなかった｡ kn-abstract=The effect of antiallergic agent, azelastine, was examined in immunogical secretory process of mast cells. 1. Azelastine significantly inhibited (45)Ca uptake by mast cells stimulated by antigen, and the maximum inhibition was attained at a concentration of 50 μg/ml showing approximately 30.5 % inhibition. 2. Azelastine also inhibite the release of histamine from mast cells by antigen. The maximal inhibitory rate was 38.1%. The effect of azelastine on (45)Ca uptake and histamine release was dose-dependent, and compatible at employed cocentration of the agent. 3. Tachpylaxis to azelastine was not found in this experimental system. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=OhtaniJun en-aut-sei=Ohtani en-aut-mei=Jun kn-aut-name=大谷純 kn-aut-sei=大谷 kn-aut-mei=純 aut-affil-num=2 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=3 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Azelastine (アゼラスチン) kn-keyword=Azelastine (アゼラスチン) en-keyword=Rat mast cells (ラット肥満細胞) kn-keyword=Rat mast cells (ラット肥満細胞) en-keyword=(45)Ca uptake (Ca(2+)uptake) kn-keyword=(45)Ca uptake (Ca(2+)uptake) en-keyword=Histamine release (ヒスタミン遊離) kn-keyword=Histamine release (ヒスタミン遊離) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=97 end-page=104 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支肺胞洗浄液中リンパ球増多と患者年齢およびIgE系アレルギー反応との関連について kn-title=Association of increased number of bronchoalveolar lymphocytes with patient age and IgE-mediated allergic reaction en-subtitle= kn-subtitle= en-abstract=気管支肺胞洗浄(BAL)液中のリンパ球頻度が30%以上の15例および20%以下の17例の気管支喘息患者を対象に,BAL液中リンパ球頻度と年齢およびIgE系反応との関連について検討を加えた｡1.BALリンパ球が高頻度(30%以上)を示す症例は,アトピー型,非アトピー型を問わず,50才以上の年齢層に多い傾向が見られた｡一方,BALリンパ球20%以下の症例の年齢は,29-63才まで幅広く分布していた｡2.発症年齢,血清IgE値,換気機能とBAL液中リンパ球頻度との間には関連は見られなかった｡3.BAL液中リンパ球頻度が高い症例では,アトピー型では平均リンパ球頻度は47.3%,非アトピー型では36.4%であったが,両群間には有意の差は見られなかった｡しかし,BAL液中のリンパ球の絶対数は,アトピー型(5.62×10(6))において,非アトピー型(0.77×10(6)) に比べ有意に高い値を示した(p<0.01)。これらの結果は,気道内リンパ球の増加は,患者年齢とIgE系反応と密接に関連していることを示唆している。 kn-abstract=The proportion and number of lymphocytes in the airways were analyzed in 15 patients with a high proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid (more than 30%) and in 17 patients with less than 20% of BAL lymphocytes. 1. Both atopic and nonatopic asthma patients with a high proportion of BAL lymphocytes were aged more than 50 years. In contrast, the age of patients with less than 20% of BAL lymphocytes ranged widely, from 29 to 63 years, in the two asthma types. 2. Age at onset of the disease, serum IgE levels, and ventilatory function test were not related to the proportion of BAL lymphocytes. 3. In patients with a high proportion of BAL lymphocytes, the mean proportion of these cells was 47.3% in atopic patients and 36.4% in non-atopic patients, i. e., there was no significant difference between the two asthma types. The absolute number of BAL lymphocytes in these patients was significantly higher in atopic (5.62×10(6)) than in nonatopic asthma (0.77×10(6)) (p<0.01). These findings show that an increased number of lymphocytes in the airways is clearly related to patient age and IgE-mediated allergic reaction. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=BAL lymphocytes kn-keyword=BAL lymphocytes en-keyword=patient age kn-keyword=patient age en-keyword=IgE-mediated allergic reaction kn-keyword=IgE-mediated allergic reaction en-keyword=bronchial asthma kn-keyword=bronchial asthma END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=111 end-page=115 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for bronchial asthma. Inhalation therapy with hot spnng water and iodine salt solution kn-title=気管支喘息の温泉療法―吸入療法 en-subtitle= kn-subtitle= en-abstract=In spa therapy for chronic obstructive pulmonary diseases, especially bronchial asthma, there are some advantages that the atmosphere around the health resort where spa therapy is administered is beneficial for the diseases as well as spa effects themselves. There are several kinds of inhalation methods and drugs used for inhalation. Although inhalation therapy uslng hot spring water and iodine salt solution is effective in bronchial asthma, analysis of pathophysiologlcal changes is the airways of asthma is necessary to increase effects of the therapy. Inhalation therapy is in general low in patients with hypersecretion or with bronchiolar obstruction. The clinical effects of inhalation therapy with iodine salt solution, which is one of the representative inhalation therapies, were marked in 4 (20%), moderate in 11 (55%), slight in 4 (20%), and of no value in one of the 20 asthma patients. kn-abstract=慢性閉塞性呼吸器疾患,特に気管支喘息に対する温泉療法は.温泉療法そのものの効果以外に,温泉保養地の周囲環境が疾患に極めて良好であるという利点を有している｡温泉水やヨードゾルによる吸入療法は,気管支喘息に対して有効であるが,治療効果をより良好なものにするためには,各喘息症例の気道内病態を十分把握しておく必要がある｡板状貯留を呈する過分泌型喘息や細気管支閉塞型喘息に対しては,吸入療法の効果は一般的に低い｡代表的なヨー ドゾル吸入療法の臨床効果は,気管支喘息20例中,著効4例(20%),有効11例(55%),やや有効4例(20%),無効1例であった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) en-keyword=吸入療法 (Inhalation therapy) kn-keyword=吸入療法 (Inhalation therapy) en-keyword=温泉水 (Hot spring water) kn-keyword=温泉水 (Hot spring water) en-keyword=ヨードゾル (lodine salt solution) kn-keyword=ヨードゾル (lodine salt solution) en-keyword=気管支喘息 (Bronchial asthma)　　　 kn-keyword=気管支喘息 (Bronchial asthma)　　　 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=105 end-page=110 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for bronchial asthma. Spa therapies effective for bronchial asthma and problems in future. kn-title=気管支喘息の温泉療法.　有効な温泉療法の種類と今後の課題 en-subtitle= kn-subtitle= en-abstract=Actions or effects of spa therapy on bronchial asthma are divided as follows : direct and indirect actions, actions for organs and whole body, and immediate and distant effects. Direct actions of spa therapy on asthma are observed in improvement of clinical symptoms and examination results related to clinical symptoms, and indirect actions of the therapy are found in improvement of suppressed function of adrenocortical glands. It has been clarified that swimming training in a hot spring pool, inhalation of iodine salt solution, and fango therepy are effective in patients with asthma. The combination of these three spa therapies is now administered for the treatment of asthma. Bronchial asthma is classified into four types accoding to clinical symptoms : Ia-1, Ia-2, Ib, and II. Type Ib and type II asthma include many of intractable asthma, and spa therapy is effective even in these intractable asthma that is difficult to control without glucocorticoids. It is necessary to develop newly devised spa therapy that is more effective in patients with asthma. kn-abstract=気管支喘息に対する温泉療法の作用,あるいは効果は,直接作用と間接作用,局所作用と全身作用,即時的効果と遠隔効果などに分類される｡気管支喘息に対する温泉療法の直接作用としては,呼吸器症状およびそれに関連した検査成績の改善として,また間接作用としては副腎皮質機能の改善作用がみられる｡一方,気管支喘息に有用な温泉療法としては,温泉プール水泳訓練,ヨードゾル吸入療法,および鉱泥湿布療法などが明らかにされており,現在これらの温泉療法を組み合わせた複合温泉療法が行われている｡気管支喘息はその臨床病態より,Ia-1.Ia-2,Ib,およびII型に分類される｡このうち,特にIb型やII型は薬物療法のみではコントロールし難い重症難治性喘息を多く含んでいる｡温泉療法は,気管支喘息全般に有効であるばかりでなく,特に薬物療法のみではコントロール困難なIb型やII型の喘息に対しても有効である。しかし,今後新たに気管支喘息に有用な温泉療法を考案して行かねばならない。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) en-keyword=温泉プール水泳訓練 (Swimming training in a hot spring pool) kn-keyword=温泉プール水泳訓練 (Swimming training in a hot spring pool) en-keyword=ヨードゾル吸入 (Inhalation of iodine salt solution) kn-keyword=ヨードゾル吸入 (Inhalation of iodine salt solution) en-keyword=鉱泥湿布療法 (Fango therapy) kn-keyword=鉱泥湿布療法 (Fango therapy) en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=106 end-page=109 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Physical therapy of patients with total hysterectomy kn-title=子宮全摘術後患者における理学療法 ―自転車エルゴメーター負荷による心拍数の変化について― en-subtitle= kn-subtitle= en-abstract=Twenty-one patients with total hysterectomy had a physical therapy program, including swimming training in a hot spring pool, muscle stretching and muscle strengthening exercise. Effects of this program were evaluated by bicycle ergometric challenge test. Maximum increased heart rate of the patients on the ergometric challenge test was significantly lower after the end of the program compared with the initial value before program (p<0.02). However, the effects of such physical therapy program on heart rate did not correlate with the frequency of the program. All patients were able to return to social work without any difficulties. These results support the efficacy of the physical therapy program in our hospital. kn-abstract=子宮全摘術を受け,回復期に理学療法を実施した患者に,自転車エルゴメーターによる同一負荷運動時の心拍数について施行前と退院時の変化を検討した｡その結果,退院時に心拍数は有意に減少した｡しかし,その減少の程度は理学療法実施回数と相関しなかった｡患者は水中運動を積極的に実施し,速やかに家庭生活を含めた社会生活への復帰が可能となった｡退院後の外来診察時に異常も認められず,理学療法の有効性並びに安全性が確認された。 en-copyright= kn-copyright= en-aut-name=KamimotoManabu en-aut-sei=Kamimoto en-aut-mei=Manabu kn-aut-name=上本学 kn-aut-sei=上本 kn-aut-mei=学 aut-affil-num=1 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=2 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院リハビリテーション部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=子宮全摘術 (Abdominal hysterectomy) kn-keyword=子宮全摘術 (Abdominal hysterectomy) en-keyword=術後理学療法 (Postoperative Physical therapy) kn-keyword=術後理学療法 (Postoperative Physical therapy) en-keyword=自転車エルゴメーター (Bicycle ergometer) kn-keyword=自転車エルゴメーター (Bicycle ergometer) en-keyword=心拍数 (Heart rate) kn-keyword=心拍数 (Heart rate) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=110 end-page=116 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Significance of spa therapy in modern medicine and its social request kn-title=現代医療における温泉療法の意義とその社会的要請 en-subtitle= kn-subtitle= en-abstract=Significance, clinical effects, action mechanisms and social request of spa therapy were discussed in relation to the treatment for patients with steroid-dependent intractable asthma (SDIA) and to modern medicine. 1. Complex spa therapy comprising swimming training in a hot spring pool, inhalation with iodine salt solution and fango therapy is highly effective in patients with SDIA. The action mechanism of complex spa therapy is clearly proved to improve the narrowing and obstruction of the small airways of those with SDIA. The complex spa therapy is more required for the treatment of asthma, because number of asthma patients with airway inflammation increases in recent years. 2. After spa therapy during admission, patients should continue their maintenance therapy to keep their asthma stable. 3. The number of patients with SDIA clearly increases, and antiasthmatic drugs except corticosteroid hormone are not effective for these patients. Thus, complex spa therapy is more necessary for the therapy of these asthma patients. kn-abstract=ステロイド依存性重症難治性喘息を中心に,温泉療法の臨床効果,作用機序およびその社会的要請について総括的な検討を行った｡1.重症型喘息に対する温泉療法としては,温泉プール水泳訓練,ヨードゾル吸入療法,鉱泥湿布療法などの有効性が高いため,これらの治療法を組合わせた複合温泉療法が現在行われている｡そして,これらの温泉療法は,いずれも細気管支領域の病変(狭窄ないし閉塞)に対して有効であり,気管支肺胞洗浄法(BAL)により観察されるairway inflammationを有する症例が増えつつある現在,極めて有用な治療法の1つと考えられる｡2.入院による温泉療法で軽快した後は,それぞれの地元で継続療法を行うことが症状の安定化のために必要である｡3.重症型喘息は当院への入院例で見る限り,明らかに増加の傾向にあり,薬物療法の限界を越えたこれらの症例の治療には温泉療法が必要であり,周囲環境の変化や高齢化社会を迎えて,その社会的要請は年ごとに増加しつつあると考えられる。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=重症型喘息 (Intractable asthma) kn-keyword=重症型喘息 (Intractable asthma) en-keyword=温泉プール水泳訓練 (Swimmlng trainlng in a hot spring pool) kn-keyword=温泉プール水泳訓練 (Swimmlng trainlng in a hot spring pool) en-keyword=ヨードゾル吸入療法 (Inhalation therapy with iodine salt solution) kn-keyword=ヨードゾル吸入療法 (Inhalation therapy with iodine salt solution) en-keyword=鉱泥湿布療法 (Fango therapy) kn-keyword=鉱泥湿布療法 (Fango therapy) en-keyword=複合温泉療法 (Complex spa therapy) kn-keyword=複合温泉療法 (Complex spa therapy) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=116 end-page=124 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pathogenic significance of IgG and IgG(4) antibodies against Candida albicans in bronchial asthma kn-title=気管支喘息におけるカンジダ特異的IgGおよびIgG(4)抗体の病因的意義について en-subtitle= kn-subtitle= en-abstract=Pathogenic significance of IgG and IgG(4) antibodies against Candida albicans was discussed in patients with bronchial asthma. An increased production of IgG and IgG(4) antibodies against Candida albicans has been observed in patients with atopic between the ages of 0 and 30, those with steroid-dependent intractable asthma between 31 and 61, and elderly patients over the age of 61. The mechanism of an increased production of IgG and IgG(4) antibodies seems to be related to atopy in patients between 0 and 30, long-term glucocorticoid therapy in those with steroid-dependent intractable asthma between 31 and 60, and aging in elderly patients over age 61. Atopy, glucocorticoid therapy and aging in general suppress cell-mediated immunity, and suppressed cell-mediated immunity increases growth of C. albicans in patient's body, leading to an increased production of IgG and IgG(4) antibodies against C. albicans. These results show that an increased production of IgG and IgG(4) antibodies against C. albicans is not always related to the pathogenesis of bronchial asthma. kn-abstract=カレジダ特異的IgG及びIgG(4)抗体が,気管支喘息の発症病態に関与しているかどうかについて検討を加えた。カンジダ特異的IgGおよびIgG(4)抗体は, 0-30才の年齢層の症例ではアトピー性素因の強い症例で,また,31-60才の年齢層の症例ではストロイド依存性重症難治性喘息症例で,さらに61才以上の高年令の症例で,その産生亢進が観察される｡これらの症例におけるIgG及びIgG(4)抗体産生は,0-30才の年齢ではアトピーとの関連で,また31-60才の年齢では副腎皮質ホルモンの長期投与と関連して,さらに61才以上の症例では加齢と関連して,細胞性免疫能が低下し,そのためカンジダの発育が促進され,その結果として,IgG及びIgG(4)抗体の産生亢進が見られることが明らかにされている｡すなわち,気管支喘息におけるカンジダに対するIgG系抗体の産生亢進は,cell-mediated immunityの低下と言う共通の基盤を有しており,病因的意義とは必ずしも関連していないことを述べた。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=カンジダ (Candida) kn-keyword=カンジダ (Candida) en-keyword=lgG抗体 (IgG antibodies) kn-keyword=lgG抗体 (IgG antibodies) en-keyword=IgG(4)抗体 (IgG(4) antibodies) kn-keyword=IgG(4)抗体 (IgG(4) antibodies) en-keyword=アトピー (Atopy) kn-keyword=アトピー (Atopy) en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=117 end-page=122 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunotherapy in house dust mite sensitive asthma kn-title=ダニ喘息患者の免疫療法 en-subtitle= kn-subtitle= en-abstract=Immunotherapy with house dust extract is employed as a treatment of patients with house dust mite sensitive bronchial asthma. Although 70-80% efficacy of the treatment is reported, mechanisms of its efficacy are not clear yet. In this paper, reported studies of IgE antibody, IgG antibody, IgG4 antibody, antiidiotypic antibody, reactivity of mast cells and function of lymphocytes are reviewed. A new type of immunotherapy with allergen antibody immune complex and a potential use of influenza virus hemaglutinin peptide analogue are also referred. kn-abstract=ダニ喘息はアトピー型喘息の典型であるが,これに対する根本療法としてアレルゲンであるハウスダストを皮下注射する免疫療法が臨床でおこなわれている。70-80%の有効性が報告されているが,その作用機序はいまだ不明である｡この稿においては特異的IgE抗体,特異的IgG抗体,特異的lgG4抗体,抗イディオタイプ抗体,肥満細胞の反応性,リンパ球の役割について総説する｡また新たな試みとしてのallergen antibody complexを使った免疫療法,ペプタイドを使用する治療の可能性についても言及する｡ en-copyright= kn-copyright= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakasi en-aut-sei=Mifune en-aut-mei=Takasi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=5 ORCID= en-aut-name=HonnkeNaoko en-aut-sei=Honnke en-aut-mei=Naoko kn-aut-name=本家尚子 kn-aut-sei=本家 kn-aut-mei=尚子 aut-affil-num=6 ORCID= en-aut-name=KusauraYasuhiro en-aut-sei=Kusaura en-aut-mei=Yasuhiro kn-aut-name=草浦康浩 kn-aut-sei=草浦 kn-aut-mei=康浩 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=ダニ喘息 (House dust mite sensitive bronchial asthma) kn-keyword=ダニ喘息 (House dust mite sensitive bronchial asthma) en-keyword=免疫療法 (lmmunotherapy) kn-keyword=免疫療法 (lmmunotherapy) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=123 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=抗原および抗ヒトIgEに対する好塩基球の反応性. 1.好塩基球数の変化 kn-title=Basophil response to antigen and anti-IgE. 1. Changes in number of basophils. en-subtitle= kn-subtitle= en-abstract=気管支喘息では,気道への抗原吸入後,好塩基球は末梢血よりアレルギー反応局所へと遊走する｡この現象は,末梢血中の好塩基球数の変動により観察することができる｡気管支喘息患者の好塩基球数は,非発作時には健常人とほぼ同じで正常範囲内にあるが,発作前段階で増加し,発作出現とともに減少する傾向を示す｡これらの所見は,好塩基球が喘息発作と密接な関連を持ちながら変動すること,そして,これらの変動を観察することにより,近い将来の発作を予知することが可能であることを示唆している｡抗原あるいは抗ヒトIgE刺激による好塩基球数の減少およびヒスタミン遊離は,全血法あるいは濃度勾配法やcounterflow centrifugation elutriation法により分離された好塩基球を用いてin vitroで観察することができる｡末梢血中の好塩基球数の減少は,好塩基球がアレルギー反応局所へと遊走したことを示している。 kn-abstract=Blood basophils in subjects with bronchial asthma migrate from blood stream into local allergic reaction sites after inhalation of antigen into airways. The phenomena can be observed by changes in number of basophils in the peripheral blood. The peripheral basophil count is at a normal level in non-attack stage of asthmatics as in healthy subjects. The basophil count increases in pre-attack stages, and decreases during attack stages. These findings suggest that number of basophils changes in close relation to asthma cycle, and that by observing number of basophils in the peripheral blood, it is possible to detect near future attacks. The decrease in number of basophils and histamine release by stimulation with antigen and anti-IgE can be observed in vitro in whole blood and basophils separated by density gradient centrifugation and by counterflow centrifugation elutriation. The decreased number of basophils in the peripheral blood represents migration of the cells into local allergic reaction sites. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=basophils (好塩基球) kn-keyword=basophils (好塩基球) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=asthma cycle (喘息発作) kn-keyword=asthma cycle (喘息発作) en-keyword=histamine release (ヒスタミン遊離) kn-keyword=histamine release (ヒスタミン遊離) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=125 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=0n climatology in Misasa spa (fifteenth report) kn-title=三朝温泉地の気候について(第15報) en-subtitle= kn-subtitle= en-abstract=Climatologlcal data of the last 12 months (1991.1.1-1991.12.31) obtained by the climate autorecording system at the Misasa Branch in Misasa spa, Tottori-ken, Japan are presented. kn-abstract=われわれは1956年以降,三朝温泉地の気候要素について観測を行ってきているが,今回は第14報にひきつづき1991年1月1日から1991年12月末日までの1カ年の気象観測の資料を報告することとした｡なお1985年4月1日以降は自動記録装置が備えられたので, 今回の資料はすべてこの自動記録装置によるものである｡ en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=EndouHiroi en-aut-sei=Endou en-aut-mei=Hiroi kn-aut-name=遠藤裕井 kn-aut-sei=遠藤 kn-aut-mei=裕井 aut-affil-num=2 ORCID= en-aut-name=InoueTaeko en-aut-sei=Inoue en-aut-mei=Taeko kn-aut-name=井上妙子 kn-aut-sei=井上 kn-aut-mei=妙子 aut-affil-num=3 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=128 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=抗原および抗ヒトIgEに対する好塩基球の反応性. 2.分泌機序における形態的変化 kn-title=Basophil response to antigen and anti-IgE. 2. Morphological changes in secretory process en-subtitle= kn-subtitle= en-abstract=抗原および抗ヒトIgE刺激時の好塩基球の形態的変化について,細胞の分泌機序(ヒスタミン遊離)との関連のもとに若干の検討を加えた｡1.抗原や抗ヒトIgE刺激時には,塗抹標本上では好塩基球の2つの形態的変化,A-form (洋梨型)とB-form(膨化型)を観察することができる｡2.抗原や抗ヒトIgE刺激時に出現する洋梨型好塩基球(反応好塩基球)は,好塩基球,好酸球同時直接 算定用染色希釈液で染色することにより,容易に観察することができる｡3.抗原添加後に反応好塩基球の出現頻度は増加する｡したがって,反応好塩基球の出現頻度を観察することにより,原因抗原を明らかにすることができる｡4.位相差顕微鏡映画による,免疫下の好塩基球の形態的変化の観察からは,好塩基球は2つの反応を取ることがわかる｡その1つは,運動亢進,すなわち oriented movementを示すことであり,他の1つは,膨化して脱顆粒現象をひき起こすことである。 kn-abstract=Morphological changes of blood basophils activated by antigen and anti-IgE were discussed in relation to release mechanisms of the cells. 1. Basophils activated by antigen and anti-IgE show two different types : A form (pear-shaped) and B from (swollen type), on smear preparartions. 2. Pear-shaped basophils(reactive basophils), which appear after stimulation by antigen and anti-IgE, can be observed by the staining solution for the direct count of basophils and eosinophils. 3. The incidence of reactive basophils increases after addition of antigen. Thus, observation of reactive basophils can be clinically applied for detecting allergen (DCRB ; direct connt of reactive basophils). 4. Observation of morphological basophil response by phase- contrast microscopic motion pictures demonstrates that basophils activated by antigen show two different reponses, increase in motility (oriented movement) and degranulation. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=2 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=3 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=morphological changes of basophils (好塩基球の形態的変化) kn-keyword=morphological changes of basophils (好塩基球の形態的変化) en-keyword=reactive basophils (反応好塩基球) kn-keyword=reactive basophils (反応好塩基球) en-keyword=degranulation (脱顆粒) kn-keyword=degranulation (脱顆粒) en-keyword=histamine release (ヒスタミン遊離) kn-keyword=histamine release (ヒスタミン遊離) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=146 end-page=153 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=134 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=抗原および抗ヒトIgEに対する抗塩基球の反応性. 3.Ca2(+)の細胞内流入およびヒスタミン遊離 kn-title=Basophil response to antigen and anti-IgE 3. Ca(2+) influx and histamine release en-subtitle= kn-subtitle= en-abstract=ハウスダスト,カンジダなどの抗原および抗ヒトIgE刺激時の,抗塩基球および肥満細胞からの化学伝達物質遊離機序について,若干の検討を行った｡1.肥満細胞へのCa(2+)の流入は,抗原刺激後に増加する傾向を示した｡この肥満細胞のCa(2+)取り込みの増加は,抗アレルギー剤であるクロモリン(DSCG)やトラニラストやCa(2+)拮抗剤であるニフェジピンやニカルジピンによって抑制された｡2.抗原(ハウスダスト)によるヒスタミン遊離の濃度依存性カーブは,抗ヒトIgEによるカーブとは異なっていた｡しかし,ハウスダストが抗原である症例では,抗原による最高ヒスタミン遊離値は,抗ヒトIgEによる遊離値とある程度の相関を示した｡そして,抗原(ハウスダスト)および抗ヒトIgEによる好塩基球からのヒスタミン遊離は,血清IgE値が上昇するにつれて,増加する傾向が見られた｡一方,カンジダによるヒスタミン遊離は,血清IgE値との相関は無く,また,抗ヒトIgEによるヒスタミン遊離との間にも関連は見られなかった。 kn-abstract=The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=Ca(2+) influx (Ca2+流入) kn-keyword=Ca(2+) influx (Ca2+流入) en-keyword=histamine release (ヒスタミン遊離) kn-keyword=histamine release (ヒスタミン遊離) en-keyword=house dust (ハウスダスト) kn-keyword=house dust (ハウスダスト) en-keyword=Candida albicans (カンジダ) kn-keyword=Candida albicans (カンジダ) en-keyword=anti-lgE (抗ヒトIgE) kn-keyword=anti-lgE (抗ヒトIgE) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=142 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息の発症における加齢の影響について kn-title=Effect of aging on onset mechanism of bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息の発症機序の一つとして,IgE抗体にmediateされる即時型アレルギー反応や好塩基球の反応性の関与が明らかにされている｡本論文では,即時型アレルギー反応や抗ヒトIgEや特異抗原に対する好塩基球の反応性が加齢によりどのような影響を受けるかについて検討を加えた｡ハウスダスト,ブタクサ,アスペルギルス,アルテルナリア,クラドスポリウム,ブロンカスマ などによる皮内反応の陽性率は,加齢とともに低下する傾向を示した｡一方カンジダによる皮内反応の陽性率は,41～50歳および61歳以上の年齢層で高度であった｡血清IgE値は加齢とともに低下する傾向がみられた｡ハウスダスト特異的IgE抗体,吸入誘発試験の陽性率は,加齢とともに低下する傾向を示した｡一方カンジダでは特異的IgE抗体,吸入誘発試験いずれも41～50歳および61歳以上の年齢層で比較的高い陽性率が観察された｡抗ヒトIgEに対する好塩基球の反応性は,血清IgEが高値(501IU/ml以上)の場合は年齢と関係なくIgE依存性であったが,血清IgE値の低い症例(301IU/ml以下)では年齢が高い群でその反応性が低い症例の比率が大きかった｡ハウスダストに対する好塩基球の反応性は,抗ヒトIgE同様年齢が高い群ほど反応性が低い症例の比率が大きかった｡カンジダに対する好塩基球の反応性は,41～50歳および61歳以上の年齢層の症例でより高度であった｡ kn-abstract=Skin tests, serum total IgE levels, specific IgE antibodies against each allergen, bronchial reactions provoked by allergens and histamine release from basophils are well known as prameters of immediate allergic reactions. The incidence of positive immediate skin reaction to allergens such as house dust, ragweed, Aspergillus Alternaria, Cladosporium and Broncasma decreased with aging. On the other hand, the incidence of positive skin reaction to Candida albicans was higher in cases between the age of 41 and 50 and cases over the age of 61 compared to that in the other groups classified by age. Serum IgE levels was highest in cases aged between 0 and 30. The levels of serum IgE decreased with aging. The incidence of positive RAST scores (more than 2+) and positive bronchial reaction to house dust were highest in cases between 0 and 30, and decreased with aging. However, the positive ratio of these tests against C. albicans were highest in cases between 41 and 50. The degree of histamine release from basophils of asthmatics induced by anti-IgE was consistently high without any correlation to aging when their serum IgE levels were more than 501 IU/ml. In the cases with serum IgE levels of less than 300 IU/ml, basophil reactivity to anti-IgE decreasd with aging. Basophil reactivity to house dust was generally dependent on the levels of specific IgE antibodies against the allergen. Although basophil reactivity to C. albicans was also high in cases with positive RAST scores, some cases with a RAST score of 0+ or 1+ showed high or moderate basophil reactivity. Moderate or high reactivity of basophils was frequently observed in cases between 41 and 50 and cases over age 61. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=Skin test (皮内反応) kn-keyword=Skin test (皮内反応) en-keyword=IgE kn-keyword=IgE en-keyword=Provocation test (吸入誘発試験) kn-keyword=Provocation test (吸入誘発試験) en-keyword=Basophil reactivity (好塩基球の反応性) kn-keyword=Basophil reactivity (好塩基球の反応性) en-keyword=Aging (加齢) kn-keyword=Aging (加齢) END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=148 end-page=153 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=看護部活動報告 ―平成3年度― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三朝分院看護部 kn-aut-sei=三朝分院看護部 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=155 end-page=175 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=0n climatology in Misasa spa(fourteenth report) kn-title=三朝温泉地の気候について(14報) en-subtitle= kn-subtitle= en-abstract=Climatological data of the last 12 months (1990.1.1-1991.12.31) obtained by the climate autorecording system at the Misasa Branch in Misasa spa, Tottori-ken, Japan are presented. kn-abstract=われわれは1956年以降,三朝温泉地の気候要素について観測を行ってきているが,今回は14報としてひきつづき1990年1月1日から1990年12月末日までの1ヵ年の気象観測の資料を報告することとした｡なお1985年4月1日以降は自動記録装置が備えられたので, 今回の資料はすべてこの自動記録装置によるものである｡ en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=EndouHiroi en-aut-sei=Endou en-aut-mei=Hiroi kn-aut-name=遠藤裕井 kn-aut-sei=遠藤 kn-aut-mei=裕井 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=176 end-page=183 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=150 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=129 end-page=149 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=0n climatology in Misasa spa (sixteenth report) kn-title=三朝温泉地の気候について(第16報) en-subtitle= kn-subtitle= en-abstract=Climatological data of the last 12 months (1992.1.1-1992.12.31) obtained by the climate autorecording system at the Misasa Branch in Misasa spa, Tottori-ken, Japan are presented. kn-abstract=われわれは1956年以降,三朝温泉地の気候要素について観測を行ってきているが,今回は第16報としてひきつづき1992年1月1日から1992年12月末日までの1カ年の気象観測の資料を報告することとした｡なお1985年4月1日以降は自動記録装置が備えられたので,今回の資料はすべてこの自動記録装置によるものである｡ en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=InoueTaeko en-aut-sei=Inoue en-aut-mei=Taeko kn-aut-name=井上妙子 kn-aut-sei=井上 kn-aut-mei=妙子 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=119 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical significance of spa therapy in patients with steroid-dependent intractable asthma kn-title=重症難治性喘息に対する温泉療法の臨床的意義 en-subtitle= kn-subtitle= en-abstract=It is very difficult or sometimes impossible for phisicians to control steroid-dependent intractable asthma (SDIA) without glucocorticoids because of the severity of asthma and low responsiveness to usual antiasthma drugs. Our previous studies have shown that spa therapy improves the symptoms and signs of patients with SDIA, suggesting that spa therapy is highly required for the treatment of SDIA. In this article, the effects and action mechanisms of spa therapy on SDIA were summarized according to the results previously described. 1. Spa therapy is more effective in patients with hypersecretion (type Ib) and bronchiolar obstruction (type II) than in those with simple bronchoconstriction (type Ia). 2. Spa therapy is more effective in patients with the age at onset over 30, and in those with the age over 40 years. 3. Obstructive dysfunction in small airways is more improved compared to that in medium or large airways by spa therapy for asthma patients. 4. Bronchial hyperresponsiveness of asthma patients is suppressed by spa therapy. 5. Markedly suppressed function of adrenocortical glands is improved by spa therapy. 6. Complex spa therapy including swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy is effective and clinically useful for the treatment of asthma patients. kn-abstract=気管支喘息のなかでも,副腎皮質ホルモン依存性の喘息は,もっとも重症難治性であり,薬物療法のみでコントロールすることは極めて困難である｡著者らの現在までの成績では,このようなステロイド依存性重症難治性喘息に対して,温泉療法は有効であった｡このことは,喘息の治療,とりわけ重症難治例の治療には温泉療法が必要不可欠であることを示している｡今回は,その臨床的有用性および機序について,若干の考察を加えた｡1.臨床病型では,Ib型やII型に重症難治症例が多く,温泉療法はこれらの病型に対して有効であった｡2.年齢別検討では,発症年齢では30才以上,また現年齢では40才以上の症例に対して温泉療法は有効であった｡3.温泉療法による換気機能の改善では,小ないし細気管支領域の閉塞の改善がより高度であった｡4.温泉療法により,気道過敏性が低下することが観察された｡5.温泉療法により,高度に低下した副腎皮質機能の改善が見られた｡5.ヨードゾル吸入,鉱泥湿布療法,温泉プール水泳ないし歩行訓練などが,喘息の治療に適した温泉療法と判断された。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=TakataIchiro en-aut-sei=Takata en-aut-mei=Ichiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=重症難治性喘息 (intractable asthma) kn-keyword=重症難治性喘息 (intractable asthma) en-keyword=換気機能 (ventilatory function) kn-keyword=換気機能 (ventilatory function) en-keyword=ヨードゾル吸入 (inhalation of iodine salt solution) kn-keyword=ヨードゾル吸入 (inhalation of iodine salt solution) en-keyword=鉱泥湿布療法 (fango therapy) kn-keyword=鉱泥湿布療法 (fango therapy) en-keyword=温泉プール水泳訓練 (swimming training in a hot spring pool) kn-keyword=温泉プール水泳訓練 (swimming training in a hot spring pool) END