ElsevierActa Medica Okayama1939-455113102020Evaluation of oral immunotherapy efficacy and safety by maintenance dose dependency: A multicenter randomized study100463ENKiyotakeOguraDepartment of Pediatrics, National Hospital Organization, Sagamihara National HospitalNoriyukiYanagidaDepartment of Pediatrics, National Hospital Organization, Sagamihara National HospitalSakuraSatoCourse of Allergy and Clinical Immunology, Juntendo University Graduate School of MedicineTakanoriImaiDepartment of Pediatrics, Showa University School of MedicineKomeiItoDepartment of Allergy, Aichi Children's Health and Medical CenterNaoyukiKandoDepartment of Allergy, Aichi Children's Health and Medical CenterMasanoriIkedaDepartment of Pediatric Acute Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesRumikoShibataDepartment of Pediatrics, National Hospital Organization, Fukuoka National HospitalYokoMurakamiDepartment of Pediatrics, National Hospital Organization, Fukuoka National HospitalTakaoFujisawaInstitute for Clinical Research, National Hospital Organization, Mie National HospitalMizuhoNagaoInstitute for Clinical Research, National Hospital Organization, Mie National HospitalNorioKawamotoDepartment of Pediatrics, Graduate School of Medicine, Gifu UniversityNaomiKondoDepartment of Pediatrics, Graduate School of Medicine, Gifu UniversityAtsuoUrisuDepartment of Pediatrics, Fujita Health University, The Second Teaching HospitalIkuyaTsugeDepartment of Pediatrics, Fujita Health University, The Second Teaching HospitalYasutoKondoDepartment of Pediatrics, Fujita Health University, The Second Teaching HospitalKazukoSugaiDepartment of Pediatrics, National Hospital Organization, Yokohama Medical CenterOsamuUchidaDepartment of Pediatrics, National Hospital Organization, Yokohama Medical CenterMitsuyoshiUrashimaDivision of Molecular Epidemiology, The Jikei University School of MedicineMasamiTaniguchiCourse of Allergy and Clinical Immunology, Juntendo University Graduate School of MedicineMotohiroEbisawaCourse of Allergy and Clinical Immunology, Juntendo University Graduate School of MedicineBackground</br>
Generally, oral immunotherapy (OIT) aims for daily administration. Recently, the efficacy of treatment with OIT at a low dose has been reported. However, the optimal dose and the evaluation of dose-dependent OIT outcome have not been described.</br>
Methods</br>
A multicenter, parallel, open-labeled, prospective, non-placebo controlled, randomized study enrolled 101 Japanese patients for treatment with OIT. We hypothesized that target dose OIT would induce short-term unresponsiveness (StU) earlier than reduced dose OIT. StU was defined as no response to 6200 mg whole egg, 3400 mg milk, and 2600 mg wheat protein, as evaluated by oral food challenge after 2-week ingestion cessation. To compare the two doses of OIT efficacy, the maximum ingestion doses during the maintenance phase of OIT were divided into 100%-dose or 25%-dose groups against their target StU dose, respectively. A total of 51 patients were assigned to the 100%-dose group [hen's egg (HE) = 26, cow's milk (CM) = 13, wheat = 12] and 50 to the 25%-dose group (HE = 25, CM = 13, wheat = 12). Primary outcome was established by comparing StU at 1 year. Secondary outcome was StU at 2 years and established by comparing allergic symptoms and immunological changes.</br>
Results</br>
The year 1 StU rates (%) for the 100%- and 25%-dose groups were 26.9 vs. 20.0 (HE), 7.7 vs. 15.4 (CM), and 50.0 vs. 16.7 (wheat), respectively. The year 2 StU rates were 30.8 vs. 36.0 (HE), 7.7 vs. 23.1 (CM), and 58.3 vs. 58.3 (wheat), respectively. There were no statistically significant differences in StU between years 1 and 2. The total allergic symptom rate in the 25%-dose group was lower than that in the 100%-dose group for egg, milk, and wheat. Antigen-specific IgE levels for egg-white, milk, and wheat decreased at 12 months.</br>
Conclusions</br>
Reduced maintenance dose of egg OIT showed similar therapeutic efficacy to the target dose. However, we were not able to clearly demonstrate the efficacy, particularly for milk and wheat. Reducing the maintenance dose for eggs, milk, and wheat may effectively lower the symptoms associated with their consumption compared to the target OIT dose. Furthermore, aggressive reduction of the maintenance dose might be important for milk and wheat, compared to the 25%-dose OIT.No potential conflict of interest relevant to this article was reported. ElsevierActa Medica Okayama2405-8440562019Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in micee01945ENHiroshiUenoDepartment of Medical Technology, Kawasaki University of Medical WelfareAtsumiShimadaDivision of Food and Nutrition, Nakamura Gakuen University Junior CollegeShunsukeSuemitsuDepartment of Psychiatry, Kawasaki Medical SchoolShinjiMurakamiDepartment of Psychiatry, Kawasaki Medical SchoolNaoyaKitamuraDepartment of Psychiatry, Kawasaki Medical SchoolKentaWaniDepartment of Psychiatry, Kawasaki Medical SchoolYosukeMatsumotoDepartment of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama UniversityMotoiOkamotoDepartment of Medical Technology, Graduate School of Health Sciences, Okayama UniversityYukoFujiwaraDepartment of Health and Sports Science, Kawasaki University of Medical WelfareTakeshiIshiharaDepartment of Psychiatry, Kawasaki Medical SchoolRosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention.No potential conflict of interest relevant to this article was reported.