JaLCDOI 10.18926/AMO/54419
フルテキストURL 70_3_197.pdf
著者 Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Sui, Kenta| Fuji, Tomokazu| Fujiwara, Toshiyoshi|
抄録 The operative mortality and morbidity of pancreaticoduodenectomy (PD) remain high. We analyzed PD patientsʼ clinical characteristics and surgical outcomes and discuss how PD clinical outcomes could be improved. We retrospectively reviewed the cases of 400 patients who underwent a PD between January 1998 and April 2014 at Okayama University Hospital, a very-high-volume center. We identified and compared the clinical outcomes between two time periods (period 1: 1998-2006 vs. period 2: 2007-2014). The total postoperative mortality and major complication rates were 0.75 and 15.8 , respectively, and the median postoperative length of stay (LOS) was 32 days. Subsequently, patients who underwent a PD during period 2 had a significantly shorter LOS than those who underwent a PD during period 1 (29 days vs. 38.5 days, p<0.001). The incidence of mortality and major complications did not differ between the two periods. In our multivariate analysis, period 1 was an independent factor associated with a long LOS (p<0.001). The improvement of the surgical procedure and perioperative care might be related to the shorter LOS in period 2 and ot the consistently maintained low mortality rate after PD. The development of multimodal strategies to accelerate postoperative recovery may further improve PDʼs clinical outcomes.
キーワード pancreaticoduodenectomy surgical outcome mortality major complication length of stay
Amo Type Original Article
発行日 2016-06
出版物タイトル Acta Medica Okayama
70巻
3号
出版者 Okayama University Medical School
開始ページ 197
終了ページ 203
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27339209
Web of Science KeyUT 000379406100007
著者 Takagi, Kosei| Yagi, Takahito| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Watanabe, Nobuyuki| Kuise, Takashi| Fuji, Tomokazu| Araki, Hiroyuki| Fujiwara, Toshiyoshi|
発行日 2017-02
出版物タイトル Acta Medica Okayama
71巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54830
フルテキストURL fulltext.pdf
著者 Miyamoto, Kazuya| Matsumoto, Kazuyuki| Kato, Hironari| Yoshida, Ryuichi| Umeda, Yuzo| Inoue, Hirohumi| Tanaka, Takehiro| Matsumi, Akihiro| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Tomoda, Takeshi| Horiguchi, Shigeru| Yagi, Takahito| Okada, Hiroyuki|
キーワード IPMN PJC LBC BD SurePath
発行日 2020-09-29
出版物タイトル BMC Gastroenterology
20巻
1号
出版者 BMC
開始ページ 319
ISSN 1471-230X
NCID AA12034934
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © The Author(s). 2020
論文のバージョン publisher
PubMed ID 32993498
DOI 10.1186/s12876-020-01465-y
Web of Science KeyUT 000576989100004
関連URL isVersionOf https://doi.org/10.1186/s12876-020-01465-y
フルテキストURL fulltext.pdf
著者 Takagi, Kosei| Kuise, Takashi| Umeda, Yuzo| Yoshida, Ryuichi| Teraishi, Fuminori| Yagi, Takahito| Fujiwara, Toshiyoshi|
キーワード Laparoscopic Liver Segment seven
発行日 2020
出版物タイトル International Journal of Surgery Case Reports
73巻
出版者 Elsevier
開始ページ 168
終了ページ 171
ISSN 2210-2612
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 The Author(s).
論文のバージョン publisher
PubMed ID 32688239
DOI 10.1016/j.ijscr.2020.06.107
Web of Science KeyUT 000558775100010
関連URL isVersionOf https://doi.org/10.1016/j.ijscr.2020.06.107
フルテキストURL fulltext.pdf
著者 Yoshida, Kazuhiro| Umeda, Yuzo| Iwamuro, Masaya| Matsumoto, Kazuyuki| Kato, Hironari| Uka, Mayu| Matsui, Yusuke| Yoshida, Ryuichi| Kuise, Takashi| Yasui, Kazuya| Takagi, Kosei| Araki, Hiroyuki| Yagi, Takahito| Fujiwara, Toshiyoshi|
キーワード Hemobilia Bile duct resection Hepatectomy Endoscopic balloon tamponade Case report
発行日 2020-12-01
出版物タイトル BMC Surgery
20巻
1号
出版者 BMC
開始ページ 307
ISSN 1471-2482
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2020.
論文のバージョン publisher
PubMed ID 33261613
DOI 10.1186/s12893-020-00981-8
Web of Science KeyUT 000595042700001
関連URL isVersionOf https://doi.org/10.1186/s12893-020-00981-8
フルテキストURL fulltext.pdf
著者 Koujima, Takeshi| Tazawa, Hiroshi| Ieda, Takeshi| Araki, Hiroyuki| Fushimi, Takuro| Shoji, Ryohei| Kuroda, Shinji| Kikuchi, Satoru| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Urata, Yasuo| Mizuguchi, Hiroyuki| Fujiwara, Toshiyoshi|
発行日 2020-06-26
出版物タイトル Molecular Therapy - Oncolytics
17巻
出版者 Cell Press
開始ページ 107
終了ページ 117
ISSN 2372-7705
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 The Author(s).
論文のバージョン publisher
PubMed ID 32322667
DOI 10.1016/j.omto.2020.03.016
Web of Science KeyUT 000544101600010
関連URL isVersionOf https://doi.org/10.1016/j.omto.2020.03.016
フルテキストURL fulltext.pdf
著者 Takagi, Kosei| Umeda, Yuzo| Kuise, Takashi| Yoshida, Ryuichi| Yoshida, Kazuhiro| Yasui, Kazuya| Tani, Yuma| Yagi, Takahito| Fujiwara, Toshiyoshi|
キーワード Hanging maneuver Laparoscopic Liver resection
発行日 2020-10-08
出版物タイトル International Journal of Surgery Case Reports
76巻
出版者 Elsevier
開始ページ 251
終了ページ 253
ISSN 2210-2612
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 The Author(s).
論文のバージョン publisher
PubMed ID 33053483
DOI 10.1016/j.ijscr.2020.10.002
関連URL isVersionOf https://doi.org/10.1016/j.ijscr.2020.10.002
フルテキストURL fulltext.pdf
著者 Ito, Atene| Kagawa, Shunsuke| Sakamoto, Shuichi| Kuwada, Kazuya| Kajioka, Hiroki| Yoshimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
キーワード Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
発行日 2021-01-28
出版物タイトル BMC Cancer
21巻
1号
出版者 BMC
開始ページ 102
ISSN 1471-2407
NCID AA12034763
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © The Author(s). 2021
論文のバージョン publisher
PubMed ID 33509150
DOI 10.1186/s12885-021-07816-6
Web of Science KeyUT 000615987400002
関連URL isVersionOf https://doi.org/10.1186/s12885-021-07816-6
フルテキストURL fulltext.pdf
著者 Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Yagi, Takahito| Fujiwara, Toshiyoshi| Zureikat, Amer H.| Hogg, Melissa E.| Koerkamp, Bas Groot|
キーワード Pancreatoduodenectomy Robotic surgery Training
発行日 2021-02-19
出版物タイトル World Journal of Surgical Oncology
19巻
1号
出版者 BMC
開始ページ 55
ISSN 1477-7819
NCID AA12048269
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © The Author(s). 2021
論文のバージョン publisher
PubMed ID 33608019
DOI 10.1186/s12957-021-02167-9
Web of Science KeyUT 000621197800003
関連URL isVersionOf https://doi.org/10.1186/s12957-021-02167-9
著者 Kajioka, Hiroki| Kagawa, Shunsuke| Ito, Atene| Yoshimoto, Masashi| Sakamoto, Shuichi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
キーワード HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model
備考 This fulltext is available in January, 2022.|
発行日 2021-01-28
出版物タイトル Cancer Letters
497巻
出版者 Elsevier
開始ページ 1
終了ページ 3
ISSN 0304-3835
NCID AA00598513
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 33065249
DOI 10.1016/j.canlet.2020.10.015
Web of Science KeyUT 000596072900001
関連URL isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015
フルテキストURL fulltext.pdf
著者 Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Yoshida, Kazuhiro| Yasui, Kazuya| Sato, Hiroki| Yagi, Takahito| Fujiwara, Toshiyoshi|
キーワード Accessory papilla of the duodenum Neuroendocrine tumor Carcinoid tumor
発行日 2021-06-30
出版物タイトル Surgical Case Reports
7巻
1号
出版者 Springer
開始ページ 156
ISSN 2198-7793
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2021.
論文のバージョン publisher
PubMed ID 34191176
DOI 10.1186/s40792-021-01241-4
Web of Science KeyUT 000671314900002
関連URL isVersionOf https://doi.org/10.1186/s40792-021-01241-4
JaLCDOI 10.18926/AMO/62410
フルテキストURL 75_4_543.pdf
著者 Yoshida, Ryuichi| Yagi, Takahito| Yasui, Kazuya| Umeda, Yuzo| Yoshida, Kazuhiro| Fuji, Tomokazu| Takagi, Kosei| Kumano, Kenjiro| Yoshimoto, Masashi| Fujiwara, Toshiyoshi|
抄録 The outcomes of pancreatectomy with resection and reconstruction of the involved arteries for locally advanced pancreatic cancer following chemotherapy have improved in recent years. In pancreatic head cancers in which there is contact with the common and proper hepatic arteries, margin-negative resection requires pancreati-coduodenectomy, with the resection of these arteries and the restoration of hepatic arterial flow. Here, we describe a middle colic artery transposition technique in hepatic arterial reconstruction during pancreatoduo-denectomy for an initially unresectable locally advanced pancreatic cancer. This technique was effective and may provide a new option for hepatic artery reconstruction in such cases.
キーワード hepatic artery locally advanced pancreatic cancer middle colic artery pancreatoduodenectomy reconstruction technique
Amo Type Case Report
発行日 2021-08
出版物タイトル Acta Medica Okayama
75巻
4号
出版者 Okayama University Medical School
開始ページ 543
終了ページ 548
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34511625
NAID 120007146036
レファレンス Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin (2014) 64: 9-29.| Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM and Matrisian LM: Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res (2014) 74: 2913-2921.| Asano T, Hirano S, Nakamura T, Okamura K, Tsuchikawa T, Noji T, Nakanishi Y, Tanaka K and Shichinohe T: Survival benefit of conversion surgery for patients with initially unresectable pan-creatic cancer who responded favorably to nonsurgical treatment. J Hepatobiliary Pancreat Sci (2018) 25: 342-350.| Gemenetzis G, Groot VP, Blair AB, Laheru DA, Zheng L, Narang AK, Fishman EK, Hruban RH, Yu J, Burkhart RA, Cameron JL, Weiss MJ, Wolfgang CL and He J: Survival in locally advanced pancreatic cancer after neoadjuvant therapy and surgical resection. Ann Surg (2019) 270: 340-347.| Bockhorn M, Burdelski C, Bogoevski D, Sgourakis G, Yekebas EF and Izbicki JR: Arterial en bloc resection for pancreatic carci-noma. Br J Surg (2011) 98: 86-92.| Amano H, Miura F, Toyota N, Wada K, Katoh K, Hayano K, Kadowaki S, Shibuya M, Maeno S, Eguchi T, Takada T and Asano T: Is pancreatectomy with arterial reconstruction a safe and useful procedure for locally advanced pancreatic cancer? J Hepatobiliary Pancreat Surg (2009) 16: 850-857.| Yoshitomi H, Takano S, Furukawa K, Takayashiki T, Kuboki S and Ohtsuka M: Conversion surgery for initially unresectable pan-creatic cancer: current status and unresolved issues. Surg Today (2019) 49: 894-906.| Bickenbach KA, Gonen M, Tang LH, OʼReilly E, Goodman K, Brennan MF, DʼAngelica MI, Dematteo RP, Fong Y, Jarnagin WR and Allen PJ: Downstaging in pancreatic cancer: a matched anal-ysis of patients resected following systemic treatment of initially locally unresectable disease. Ann Surg Oncol (2012) 19: 1663-1669.| Strobel O, Berens V, Hinz U, Hartwig W, Hackert T, Bergmann F, Debus J, Jäger D, Büchler MW and Werner J: Resection after neoadjuvant therapy for locally advanced, “unresectable” pancre-atic cancer. Surgery (2012) 152:S33-S42.| Tempero MA, Malafa MP, Al-Hawary M, Behrman SW, Benson AB, Cardin DB, Chiorean EG, Chung V, Czito B, Del Chiaro M, Dillhoff M, Donahue TR, Dotan E, Ferrone CR, Fountzilas C, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Moravek C, Nakakura EK, Narang AK, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Vollmer C, Wolff RA, Wolpin BM, Lynn B and George GV: Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw (2021) 19: 439-457.| Natsume S, Shimizu Y, Senda Y, Hijioka S, Matsuo K, Ito S, Komori K, Abe T and Hara K: Conversion surgery only for highly selected patients with unresectable pancreatic cancer: a satisfactory outcome in exchange for a lower resection rate. Surg Today (2019) 49: 670-677.| Miyazaki M, Yoshitomi H, Takano S, Shimizu H, Kato A, Yoshidome H, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N and Ohtuka M: Combined hepatic arterial resection in pancreatic resections for locally advanced pancreatic cancer. Langenbecks Arch Surg (2017) 402: 447-456.| Mollberg N, Rahbari NN, Koch M, Hartwig W, Hoeger Y, Büchler MW and Weitz J: Arterial resection during pancreatectomy for pan-creatic cancer: a systematic review and meta-analysis. 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Transl Gastroenterol Hepatol (2019) 4: 8.| Brasoveanu V, Romanescu D, Diaconu C, Iliescu L, Stiru O, Brezean I, Belu E, Savu C, Savu C, Bratu O, Gorecki G, Pop L, Balescu I and Bacalbasa N: Hepatic artery reconstruction after extended resection for borderline resectable pancreatic head can-cer: A case report. Exp Ther Med (2021) 21: 87.| Tanaka H, Imai H, Higashi T, Murase K, Matsuhashi N and Yoshida K: Splenic artery transposition for hepatic arterial recon-struction in conversion surgery of an initially unresectable, locally advanced pancreatic cancer after gemcitabine/nab-paclitaxel: A case report. Int J Surg Case Rep (2021) 78: 192-196.| Stitzenberg KB, Watson JC, Roberts A, Kagan SA, Cohen SJ, Konski AA and Hoffman JP: Survival after pancreatectomy with major arterial resection and reconstruction. 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JaLCDOI 10.18926/AMO/62818
フルテキストURL 75_6_755.pdf
著者 Takagi, Kosei| Kuise, Takashi| Umeda, Yuzo| Yoshida, Ryuichi| Yoshida, Kazuhiro| Nagai, Yasuo| Noma, Kazuhiro| Tanabe, Shunsuke| Maeda, Naoaki| Yagi, Takahito| Fujiwara, Toshiyoshi|
抄録 Approximately 4% of patients with esophageal cancer develop a second primary malignancy in the upper gastrointestinal trunk. However, hepatectomy following esophagectomy for esophageal cancer has rarely been reported. We report the case of a 70-year-old man who underwent an esophagectomy for esophageal cancer with retrosternal gastric tube reconstruction. Nine years later, he developed hepatocellular carcinoma with tumor thrombus involving the left portal vein, and was successfully treated with left hemihepatectomy. Special attention should be paid to avoiding incidental injury of the gastric tube as well as the right gastroepiploic artery during the hepatectomy.
キーワード liver resection, esophagectomy, retrosternal gastric tube reconstruction
Amo Type Case Report
発行日 2021-12
出版物タイトル Acta Medica Okayama
75巻
6号
出版者 Okayama University Medical School
開始ページ 755
終了ページ 758
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
レファレンス Moaven O and Wang TN: Combined Modality Therapy for Management of Esophageal Cancer: Current Approach Based on Experiences from East and West. Surg Clin North Am (2019) 99: 479-499.| Zhu G, Chen Y, Zhu Z, Lu L, Bi X, Deng Q, Chen X, Su H, Liu Y, Guo H, Zheng T, Yu H and Zhang Y: Risk of second primary cancer after treatment for esophageal cancer: a pooled analysis of nine cancer registries. Dis Esophagus (2012) 25: 505-511.| Honig SE, Lundgren MP, Kowalski TE, Lavu H and Yeo CJ: Advanced Endoscopic Rescue of a Complication (Duodenojejunostomy Leak) After a Pylorus-Preserving Pancreaticoduodenectomy in a Post-Esophagectomy Patient with Pancreatic Adenocarcinoma: A Case Report and Review of the Literature. J Pancreat Cancer (2020) 6: 5-11.| Gentile D, Riva P, Da Roit A, Basato S, Marano S and Castoro C: Gastric tube cancer after esophagectomy for cancer: a systematic review. Dis Esophagus (2019) 32.| Chen H, Lu JJ, Zhou J, Zhou X, Luo X, Liu Q and Tam J: Anterior versus posterior routes of reconstruction after esophagectomy: a comparative anatomic study. Ann Thorac Surg (2009) 87: 400-404.| Shirakawa Y, Noma K, Maeda N, Katsube R, Tanabe S, Ohara T, Sakurama K and Fujiwara T: Assistant-based standardization of prone position thoracoscopic esophagectomy. Acta Med Okayama (2014) 68: 111-117.| Kokudo N, Takemura N, Hasegawa K, Takayama T, Kubo S, Shimada M, Nagano H, Hatano E, Izumi N, Kaneko S, Kudo M, Iijima H, Genda T, Tateishi R, Torimura T, Igaki H, Kobayashi S, Sakurai H, Murakami T, Watadani T and Matsuyama Y: Clinical practice guidelines for hepatocellular carcinoma: The Japan Society of Hepatology 2017 ( 4th JSH-HCC guidelines) 2019 update. Hepatol Res (2019) 49: 1109-1113.| Kokudo T, Hasegawa K, Matsuyama Y, Takayama T, Izumi N, Kadoya M, Kudo M, Ku Y, Sakamoto M, Nakashima O, Kaneko S and Kokudo N; Liver Cancer Study Group of Japan: Survival benefit of liver resection for hepatocellular carcinoma associated with portal vein invasion. J Hepatol (2016) 65: 938-943.| Nanashima A, Hiyoshi M, Imamura N, Yano K, Hamada T, Wada T, Nishida T, Tsuchiya K, Kawano F, Ikeda T and Takeno S: A cohort study on the risk of hepatectomy and pancreatectomy after history of abdominal surgery on other organs. Ann Hepatobiliary Pancreat Surg (2018) 22: 344-349.| Melnik BC: Dairy consumption and hepatocellular carcinoma risk. Ann Transl Med (2021) 9: 736.| Song A, Wang X, Lu J, Jin Y, Ma L, Hu Z, Zheng Y, Shen C and Chen X: Durability of hepatitis B surface antigen seroclearance and subsequent risk for hepatocellular carcinoma: A meta-analysis. J Viral Hepat (2021) 28: 601-612.|
JaLCDOI 10.18926/AMO/49671
フルテキストURL 67_2_117.pdf
著者 Sadamori, Hiroshi| Yagi, Takahito| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Sato, Daisuke| Nobuoka, Daisuke| Utsumi, Masashi| Fujiwara, Toshiyoshi|
抄録 We present a case of living donor liver transplantation to a 3-year disease-free survivor of liver resection for hepatocellular carcinoma (HCC) with major portal vein invasion. A 48-year-old man had HCC in the right lobe with a portal venous tumor thrombus extending into the left portal vein. An extended right lobectomy with thrombectomy was performed to remove the thrombus. Three years after liver resection, the patient experienced liver failure, with massive ascites and jaundice due to the formation of a thrombus in the main and left portal veins. During the 3 years after liver resection, no metastasis or recurrence of HCC had been detected, and tumor markers had been within normal ranges. The portal venous thrombus did not show any arterial enhancement under contrast-enhanced computed tomography, suggesting that the co-existence of any HCC component in the portal venous thrombus may have been negative. Based on these findings, living donor liver transplantation was performed using a right lobe graft from the patientʼs son. The patient is alive at 87 months after the transplantation, with no evidence of HCC recurrence.
キーワード living donor liver transplantation hepatocellular carcinoma portal vein invasion liver resection
Amo Type Case Report
発行日 2013-04
出版物タイトル Acta Medica Okayama
67巻
2号
出版者 Okayama University Medical School
開始ページ 117
終了ページ 121
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23603929
Web of Science KeyUT 000317801700007
JaLCDOI 10.18926/AMO/54594
フルテキストURL 70_5_363.pdf
著者 Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Fujiwara, Toshiyoshi|
抄録 Sarcopenia following liver surgery has been reported as a predictor of poor prognosis. Here we investigated predictors of outcomes in patients with hepatocellular carcinoma (HCC) and attempted to establish a new comprehensive preoperative assessment protocol. We retrospectively analyzed the cases of 254 patients who underwent curative hepatectomy for HCC with Child-Pugh classification A at our hospital between January 2007 and December 2013. Sarcopenia was evaluated by computed tomography measurement. The influence of sarcopenia on outcomes was evaluated. We used multivariate analyses to assess the impact of prognostic factors associated with outcomes, including sarcopenia. Of the 254 patients, 118 (46.5%) met the criteria for sarcopenia, and 32 had an American Society of Anesthesiologists (ASA) physical status ≥3. The sarcopenic group had a significantly lower 5-year overall survival rate than the non-sarcopenic group (58.2% vs. 82.4% , p=0.0002). In multivariate analyses of prognostic factors, sarcopenia was an independent predictor of poor survival (hazard ratio [HR]=2.28, p=0.002) and poor ASA status (HR=3.17, p=0.001). Sarcopenia and poor ASA status are independent preoperative predictors for poor outcomes after hepatectomy. The preoperative identification of sarcopenia and ASA status might enable the development of comprehensive approaches to assess surgical eligibility.
キーワード sarcopenia American Society of Anesthesiologists physical status hepatectomy hepatocellular carcinoma prognostic factor
Amo Type Original Articles
発行日 2016-10
出版物タイトル Acta Medica Okayama
70巻
5号
出版者 Okayama University Medical School
開始ページ 363
終了ページ 370
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27777428
Web of Science KeyUT 000388098700005
JaLCDOI 10.18926/AMO/55435
フルテキストURL 71_5_381.pdf
著者 Yoshida, Kazuhiro| Umeda, Yuzo| Takaki, Akinobu| Nagasaka, Takeshi| Yoshida, Ryuichi| Nobuoka, Daisuke| Kuise, Takashi| Takagi, Kosei| Yasunaka, Tetsuya| Okada, Hiroyuki| Yagi, Takahito| Fujiwara, Toshiyoshi|
抄録 Determining the indications for and timing of liver transplantation (LT) for acute liver failure (ALF) is essential. The King’s College Hospital (KCH) guidelines and Japanese guidelines are used to predict the need for LT and the outcomes in ALF. These guidelines’ accuracy when applied to ALF in different regional and etiological backgrounds may differ. Here we compared the accuracy of new (2010) Japanese guidelines that use a simple scoring system with the 1996 Japanese guidelines and the KCH criteria for living donor liver transplantation (LDLT). We retrospectively analyzed 24 adult ALF patients (18 acute type, 6 sub-acute type) who underwent LDLT in 1998-2009 at our institution. We assessed the accuracies of the 3 guidelines’ criteria for ALF. The overall 1-year survival rate was 87.5%. The new and previous Japanese guidelines were superior to the KCH criteria for accurately predicting LT for acute-type ALF (72% vs. 17%). The new Japanese guidelines could identify 13 acute-type ALF patients for LT, based on the timing of encephalopathy onset. Using the previous Japanese guidelines, although the same 13 acute-type ALF patients (72%) had indications for LT, only 4 patients were indicated at the 1st step, and it took an additional 5 days to decide the indication at the 2nd step in the other 9 cases. Our findings showed that the new Japanese guidelines can predict the indications for LT and provide a reliable alternative to the previous Japanese and KCH guidelines.
キーワード living donor liver transplantation acute liver failure fulminant hepatic failure
Amo Type Original Article
発行日 2017-10
出版物タイトル Acta Medica Okayama
71巻
5号
出版者 Okayama University Medical School
開始ページ 381
終了ページ 390
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29042695
フルテキストURL OncoImmunol_8_12_1671760.pdf
著者 Sakamoto, Shuichi| Kagawa, Shunsuke| Kuwada, Kazuya| Ito, Atene| Kajioka, Hiroki| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kagawa, Tetsuya| Yoshida, Ryuichi| Kikuchi, Satoru| Kuroda, Shinji| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
キーワード Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
発行日 2019-10-22
出版物タイトル OncoImmunology
8巻
12号
出版者 TAYLOR & FRANCIS
開始ページ e1671760
ISSN 2162402X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2019 The Author(s).
論文のバージョン publisher
DOI 10.1080/2162402X.2019.1671760
Web of Science KeyUT 000494085400001
関連URL isVersionOf https://doi.org/10.1080/2162402X.2019.1671760
フルテキストURL fulltext.pdf
著者 Matsumoto, Naohisa| Matsusaki, Takashi| Hiroi, Kazumasa| Kaku, Ryuji| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Morimatsu, Hiroshi|
備考 11th Congress of the Andalusian-Society-of-Organ-and-Tissue-Transplantation (SATOT)|
発行日 2020-03-31
出版物タイトル Transplantation Proceedings
52巻
2号
出版者 Elsevier
開始ページ 630
終了ページ 633
ISSN 00411345
NCID AA00868957
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 The Authors. Published by Elsevier Inc.
論文のバージョン publisher
PubMed ID 32029317
DOI 10.1016/j.transproceed.2019.11.032
Web of Science KeyUT 000518473000059
関連URL isVersionOf https://doi.org/10.1016/j.transproceed.2019.11.032
JaLCDOI 10.18926/AMO/52898
フルテキストURL 68_5_291.pdf
著者 Tsuzaki, Ryuichiro| Takaki, Akinobu| Yagi, Takahito| Ikeda, Fusao| Koike, Kazuko| Iwasaki, Yoshiaki| Shiraha, Hidenori| Miyake, Yasuhiro| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Utsumi, Masashi| Nakayama, Eiichi| Fujiwara, Toshiyoshi| Yamamoto, Kazuhide|
抄録 It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At>3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect.
キーワード interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell
Amo Type Original Article
発行日 2014-10
出版物タイトル Acta Medica Okayama
68巻
5号
出版者 Okayama University Medical School
開始ページ 291
終了ページ 302
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25338486
Web of Science KeyUT 000343269300006
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/53129
フルテキストURL JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg
著者 Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Tanaka, Noriyuki| Kato, Hironari| Horiguchi, Shigeru| Yoshida, Ryuichi| Umeda, Yuzo| Fushimi, Soichiro| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki|
キーワード Immunohistochemistry PD-L1 Pancreatic cancer
備考 This fulltext will be available in Apr 2020|
発行日 2019-04-29
出版物タイトル Journal of Gastroenterology
54巻
11号
開始ページ 1019
終了ページ 1028
ISSN 09441174
NCID AA10988015
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31032528
DOI 10.1007/s00535-019-01586-6
Web of Science KeyUT 000492169400008
関連URL isVersionOf https://doi.org/10.1007/s00535-019-01586-6